Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	pyruvate kinase activity	PKLR PKM	4.60e-05	2	136	2	GO:0004743
GeneOntologyMolecularFunction	steroid 11-beta-monooxygenase activity	CYP11B1 CYP11B2	4.60e-05	2	136	2	GO:0004507
GeneOntologyMolecularFunction	corticosterone 18-monooxygenase activity	CYP11B1 CYP11B2	4.60e-05	2	136	2	GO:0047783
GeneOntologyMolecularFunction	L-ascorbic acid binding	P3H3 ALKBH3 PLOD2	3.24e-04	20	136	3	GO:0031418
GeneOntologyBiologicalProcess	detection of mechanical stimulus involved in sensory perception of sound	ADGRV1 PCDH15 KCNQ1 CHRNA10	1.37e-05	23	134	4	GO:0050910
GeneOntologyBiologicalProcess	cell-cell junction maintenance	CAMSAP3 EPB41L3 PKP2 INAVA	1.37e-05	23	134	4	GO:0045217
GeneOntologyBiologicalProcess	adherens junction maintenance	CAMSAP3 PKP2 INAVA	2.19e-05	9	134	3	GO:0034334
GeneOntologyBiologicalProcess	regulation of protein depolymerization	FLII HTR1A APC2 KATNB1 CAMSAP3 TRIOBP	6.39e-05	105	134	6	GO:1901879
GeneOntologyBiologicalProcess	cell junction maintenance	CAMSAP3 EPB41L3 SHANK2 PKP2 INAVA	6.49e-05	65	134	5	GO:0034331
GeneOntologyBiologicalProcess	inner ear receptor cell development	TRIOBP ADGRV1 TTC8 PCDH15 KCNQ1	1.13e-04	73	134	5	GO:0060119
GeneOntologyCellularComponent	pyruvate kinase complex	PKLR PKM	4.52e-05	2	141	2	GO:1902912
MousePheno	abnormal urine progesterone level	CYP11B1 CYP11B2	6.83e-05	2	116	2	MP:0011545
MousePheno	abnormal urine deoxycorticosterone level	CYP11B1 CYP11B2	6.83e-05	2	116	2	MP:0011552
MousePheno	decreased urine corticosterone level	CYP11B1 CYP11B2	6.83e-05	2	116	2	MP:0011550
MousePheno	increased urine deoxycorticosterone level	CYP11B1 CYP11B2	6.83e-05	2	116	2	MP:0011553
MousePheno	increased urine progesterone level	CYP11B1 CYP11B2	6.83e-05	2	116	2	MP:0011546
Domain	-	PKLR PKM	5.50e-05	2	139	2	3.40.1380.20
Domain	PYRUVATE_KINASE	PKLR PKM	5.50e-05	2	139	2	PS00110
Domain	Pyrv_Knase_insert_dom	PKLR PKM	5.50e-05	2	139	2	IPR015806
Domain	PK	PKLR PKM	5.50e-05	2	139	2	PF00224
Domain	PK_C	PKLR PKM	5.50e-05	2	139	2	PF02887
Domain	-	PKLR PKM	5.50e-05	2	139	2	2.40.33.10
Domain	Cyt_P450_mitochondrial	CYP11B1 CYP11B2	5.50e-05	2	139	2	IPR002399
Domain	Pyrv_Knase_AS	PKLR PKM	5.50e-05	2	139	2	IPR018209
Domain	Pyrv_Knase_brl	PKLR PKM	5.50e-05	2	139	2	IPR015793
Domain	Pyrv_Knase_a/b	PKLR PKM	5.50e-05	2	139	2	IPR015794
Domain	Pyrv_Knase_C	PKLR PKM	5.50e-05	2	139	2	IPR015795
Domain	Pyr_Knase	PKLR PKM	1.64e-04	3	139	2	IPR001697
Domain	Pyrv/PenolPyrv_Kinase-like_dom	PKLR PKM	1.64e-04	3	139	2	IPR015813
Domain	-	PKLR PKM	1.64e-04	3	139	2	3.20.20.60
Domain	2OG-FeII_Oxy	P3H3 ALKBH3 PLOD2	3.58e-04	19	139	3	PF03171
Domain	FN3	BOC COL20A1 CMYA5 KIAA0319 PTPRG EBI3 IGSF9	4.75e-04	185	139	7	SM00060
Domain	FE2OG_OXY	P3H3 ALKBH3 PLOD2	4.86e-04	21	139	3	PS51471
Domain	Pyrv_Knase-like_insert_dom	PKLR PKM	5.42e-04	5	139	2	IPR011037
Domain	Oxoglu/Fe-dep_dioxygenase	P3H3 ALKBH3 PLOD2	6.41e-04	23	139	3	IPR005123
Domain	VWA	ITGA11 COL20A1 CACHD1 ITIH5	7.99e-04	56	139	4	PF00092
Domain	Ig-like_fold	BOC SEMA3F COL20A1 CMYA5 KIAA0319 IGSF10 SHANK2 PTPRG EBI3 VCAN NCAN IGSF9 CD300E IGLON5	8.01e-04	706	139	14	IPR013783
Domain	FN3_dom	BOC COL20A1 CMYA5 KIAA0319 PTPRG EBI3 IGSF9	9.75e-04	209	139	7	IPR003961
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SEMA3F FLII B4GALNT4 TRMT11 TWNK CTDNEP1 JAK3 DIP2A TNRC18 LLGL2 SCAP SHANK2 MROH6 ZNRF3 CANT1 RRP12 USP40 SORBS3 NLRC5 IL17RD PKN3 TJP3	8.66e-10	1105	142	22	35748872
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	FLII SRSF1 CCT3 PPP1R12A APC2 CAMSAP3 TRIOBP ARHGEF18 EPB41L3 KIAA0319 SHANK2 NCAN CNKSR3 DOCK7 CCAR1 STIP1 PCDH8	4.53e-07	963	142	17	28671696
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	CCT3 SHB ABCC5 MCM4 CACHD1 EPB41L3 DENND4C DOCK7 PKM PKP2 AGK STIP1 TAF7 DHX29	1.35e-06	708	142	14	39231216
Pubmed	A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis.	CYP11B1 CYP11B2 ZNRF3	2.30e-06	7	142	3	30692207
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	FLII SNPH ATP6AP1 SRSF1 CCT3 PDK1 PPP1R12A CAMSAP3 EPB41L3 LRRC47 DIP2A PPP2R2A SHANK2 VCAN NCAN DOCK7 PKM STIP1 DHX29	6.21e-06	1431	142	19	37142655
Pubmed	Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.	CYP11B1 CYP11B2	1.66e-05	2	142	2	23150505
Pubmed	GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	1.66e-05	2	142	2	35012455
Pubmed	Role of genetic variation in regulation of aldosterone biosynthesis.	CYP11B1 CYP11B2	1.66e-05	2	142	2	21164264
Pubmed	Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia.	PKLR PKM	1.66e-05	2	142	2	11960989
Pubmed	The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity.	CYP11B1 CYP11B2	1.66e-05	2	142	2	8645611
Pubmed	Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.	PKLR PKM	1.66e-05	2	142	2	15996096
Pubmed	Expression and localization of cytochrome P450(11beta,aldo) mRNA in the frog brain.	CYP11B1 CYP11B2	1.66e-05	2	142	2	12231255
Pubmed	A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I.	CYP11B1 CYP11B2	1.66e-05	2	142	2	20634641
Pubmed	Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.	CYP11B1 CYP11B2	1.66e-05	2	142	2	1303253
Pubmed	Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.	CYP11B1 CYP11B2	1.66e-05	2	142	2	1741400
Pubmed	Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice.	CYP11B1 CYP11B2	1.66e-05	2	142	2	32540969
Pubmed	Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.	CYP11B1 CYP11B2	1.66e-05	2	142	2	26047574
Pubmed	Aldosterone synthase knockout mouse as a model for sodium-induced endothelial sodium channel up-regulation in vascular endothelium.	CYP11B1 CYP11B2	1.66e-05	2	142	2	26324851
Pubmed	Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains.	CYP11B1 CYP11B2	1.66e-05	2	142	2	7669222
Pubmed	Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.	CYP11B1 CYP11B2	1.66e-05	2	142	2	22933298
Pubmed	Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	1.66e-05	2	142	2	2783417
Pubmed	Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.	CYP11B1 CYP11B2	1.66e-05	2	142	2	2256920
Pubmed	Association of DNA polymorphisms within the CYP11B2/CYP11B1 locus and postoperative hypertension risk in the patients with aldosterone-producing adenomas.	CYP11B1 CYP11B2	1.66e-05	2	142	2	20708777
Pubmed	Molecular genetic studies on the biosynthesis of aldosterone in humans.	CYP11B1 CYP11B2	1.66e-05	2	142	2	22217843
Pubmed	Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation.	CYP11B1 CYP11B2	1.66e-05	2	142	2	16396990
Pubmed	[123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes.	CYP11B1 CYP11B2	1.66e-05	2	142	2	18397978
Pubmed	Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.	CYP11B1 CYP11B2	1.66e-05	2	142	2	1518866
Pubmed	Procollagen I-expressing renin cell precursors.	CYP11B1 CYP11B2	1.66e-05	2	142	2	23761669
Pubmed	Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).	CYP11B1 CYP11B2	1.66e-05	2	142	2	2592361
Pubmed	Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice.	CYP11B1 CYP11B2	1.66e-05	2	142	2	23314847
Pubmed	Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects.	CYP11B1 CYP11B2	1.66e-05	2	142	2	17980006
Pubmed	Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.	CYP11B1 CYP11B2	1.66e-05	2	142	2	16984984
Pubmed	Evidence for local aldosterone synthesis in the large intestine of the mouse.	CYP11B1 CYP11B2	1.66e-05	2	142	2	35288482
Pubmed	Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.	CYP11B1 CYP11B2	1.66e-05	2	142	2	15731365
Pubmed	SRSF1 interactome determined by proximity labeling reveals direct interaction with spliceosomal RNA helicase DDX23.	SRSF1 DDX23	1.66e-05	2	142	2	38743621
Pubmed	Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.	CYP11B1 CYP11B2	1.66e-05	2	142	2	17651452
Pubmed	Expression of CYP11B1 and CYP11B2 in adrenal adenoma correlates with clinical characteristics of primary aldosteronism.	CYP11B1 CYP11B2	1.66e-05	2	142	2	34743356
Pubmed	Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.	CYP11B1 CYP11B2	1.66e-05	2	142	2	20339375
Pubmed	Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	1.66e-05	2	142	2	20808686
Pubmed	Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets.	CYP11B1 CYP11B2	1.66e-05	2	142	2	21519965
Pubmed	Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children.	CYP11B1 CYP11B2	1.66e-05	2	142	2	21625068
Pubmed	Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.	CYP11B1 CYP11B2	1.66e-05	2	142	2	16110193
Pubmed	Chimeric CYP11B2/CYP11B1 causing 11β-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.	CYP11B1 CYP11B2	1.66e-05	2	142	2	26066897
Pubmed	Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.	CYP11B1 CYP11B2	1.66e-05	2	142	2	18651133
Pubmed	A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern.	CYP11B1 CYP11B2	1.66e-05	2	142	2	22083159
Pubmed	The mammalian homolog of suppressor-of-white-apricot regulates alternative mRNA splicing of CD45 exon 4 and fibronectin IIICS.	SRSF1 SFSWAP	1.66e-05	2	142	2	8940107
Pubmed	Editorial: polymorphisms in CYP11B genes and 11-hydroxylase activity.	CYP11B1 CYP11B2	1.66e-05	2	142	2	15699546
Pubmed	Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.	CYP11B1 CYP11B2	1.66e-05	2	142	2	18162527
Pubmed	Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism.	CYP11B1 CYP11B2	1.66e-05	2	142	2	38341019
Pubmed	Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.	CYP11B1 CYP11B2	1.66e-05	2	142	2	24837548
Pubmed	Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity.	CYP11B1 CYP11B2	1.66e-05	2	142	2	30046010
Pubmed	Familial and phenotypic associations of the aldosterone Renin ratio.	CYP11B1 CYP11B2	1.66e-05	2	142	2	19820005
Pubmed	Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.	CYP11B1 CYP11B2	1.66e-05	2	142	2	22622494
Pubmed	Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production.	CYP11B1 CYP11B2	1.66e-05	2	142	2	15062555
Pubmed	Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.	CYP11B1 CYP11B2	1.66e-05	2	142	2	17075030
Pubmed	Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.	CYP11B1 CYP11B2	1.66e-05	2	142	2	17075029
Pubmed	CYP11B2-CYP11B1 haplotypes associated with decreased 11 beta-hydroxylase activity.	CYP11B1 CYP11B2	1.66e-05	2	142	2	15507509
Pubmed	Polymorphism of CYP11B2 determines salt sensitivity in Japanese.	CYP11B1 CYP11B2	1.66e-05	2	142	2	17296872
Pubmed	Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.	CYP11B1 CYP11B2	1.66e-05	2	142	2	18039983
Pubmed	Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.	CYP11B1 CYP11B2	1.66e-05	2	142	2	19029289
Pubmed	Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.	CYP11B1 CYP11B2	1.66e-05	2	142	2	15522937
Pubmed	Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.	TRIOBP ADGRV1 PCDH15	2.35e-05	14	142	3	26754646
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	SEMA3F ENDOD1 ITGA11 B3GNT9 ATP6AP1 P3H3 LEMD2 CACHD1 IGSF10 PPP2R2A SCAP MOGS CANT1 RRP12 CLN6 PLOD2	3.40e-05	1201	142	16	35696571
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ENDOD1 PPP1R12A SHB CAMSAP3 TRIOBP ARHGEF18 ADGRV1 NXN TTC8 PPP2R2A TNRC18 SHANK2 PTPRG USP40 CCAR1 NLRC5 IGSF9 SMYD3	3.83e-05	1489	142	18	28611215
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SRSF1 SFSWAP PDK1 TRIOBP EPB41L3 MOGS CLK3 VCAN RRP12 PCDH15 DOCK7 PKM CCAR1 AGK DDX23	3.88e-05	1082	142	15	38697112
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	VTN MCM4 MAP3K6 PPP2R2A MOGS RRP12 CNKSR3 RLIM DDX23 PJA1 PKN3	4.18e-05	606	142	11	36538041
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	ENDOD1 ATP6AP1 SRSF1 EPB41L3 RLIM DOCK7 PJA1 PKN3	4.65e-05	313	142	8	38270169
Pubmed	Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex.	KATNB1 CAMSAP3	4.95e-05	3	142	2	29395789
Pubmed	The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.	CYP11B1 CYP11B2	4.95e-05	3	142	2	2546938
Pubmed	Kidney function in mice lacking aldosterone.	CYP11B1 CYP11B2	4.95e-05	3	142	2	16118390
Pubmed	Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure.	LEMD2 CTDNEP1	4.95e-05	3	142	2	32271860
Pubmed	Aldosterone-induced coronary dysfunction in transgenic mice involves the calcium-activated potassium (BKCa) channels of vascular smooth muscle cells.	CYP11B1 CYP11B2	4.95e-05	3	142	2	17984374
Pubmed	STIP1 down-regulation inhibits glycolysis by suppressing PKM2 and LDHA and inactivating the Wnt/β-catenin pathway in cervical carcinoma cells.	PKM STIP1	4.95e-05	3	142	2	32777299
Pubmed	Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	4.95e-05	3	142	2	2233742
Pubmed	Substrate-induced modulation of protein-protein interactions within human mitochondrial cytochrome P450-dependent system.	CYP11B1 CYP11B2	4.95e-05	3	142	2	33271253
Pubmed	The prolactin regulatory element-binding regulates of the 11beta-hydroxylase gene.	CYP11B1 CYP11B2	4.95e-05	3	142	2	18801336
Pubmed	Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1.	CYP11B1 CYP11B2	4.95e-05	3	142	2	11932209
Pubmed	Interactions with M-band titin and calpain 3 link myospryn (CMYA5) to tibial and limb-girdle muscular dystrophies.	CAPN3 CMYA5	4.95e-05	3	142	2	20634290
Pubmed	Aldosterone postnatally, but not at birth, is required for optimal induction of renal mineralocorticoid receptor expression and sodium reabsorption.	CYP11B1 CYP11B2	4.95e-05	3	142	2	21467193
Pubmed	Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.	CYP11B1 CYP11B2	4.95e-05	3	142	2	7750493
Pubmed	Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis.	CYP11B1 CYP11B2	4.95e-05	3	142	2	26471128
Pubmed	Regulated vesicular trafficking of specific PCDH15 and VLGR1 variants in auditory hair cells.	ADGRV1 PCDH15	4.95e-05	3	142	2	23035094
Pubmed	Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.	CYP11B1 CYP11B2	4.95e-05	3	142	2	28355486
Pubmed	Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.	CYP11B1 CYP11B2	4.95e-05	3	142	2	36861295
Pubmed	Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior.	CYP11B1 CYP11B2	4.95e-05	3	142	2	36778748
Pubmed	Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.	CYP11B1 CYP11B2	4.95e-05	3	142	2	8111631
Pubmed	Interaction of CYP11B1 (cytochrome P-45011 beta) with CYP11A1 (cytochrome P-450scc) in COS-1 cells.	CYP11B1 CYP11B2	4.95e-05	3	142	2	10411633
Pubmed	Differential effects of high and low steroidogenic factor-1 expression on CYP11B2 expression and aldosterone production in adrenocortical cells.	CYP11B1 CYP11B2	4.95e-05	3	142	2	18974272
Pubmed	Different isozymes of mouse 11 beta-hydroxylase produce mineralocorticoids and glucocorticoids.	CYP11B1 CYP11B2	4.95e-05	3	142	2	1686470
Pubmed	Mislocalization of protein kinase A drives pathology in Cushing's syndrome.	CYP11B1 CYP11B2	4.95e-05	3	142	2	35830806
Pubmed	Increased expression of lysosomal acid phosphatase in CLN3-defective cells and mouse brain tissue.	ACP2 CLN6	4.95e-05	3	142	2	17868323
Pubmed	Control of renin secretion from kidneys with renin cell hyperplasia.	CYP11B1 CYP11B2	4.95e-05	3	142	2	24285498
Pubmed	Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes.	CYP11B1 CYP11B2	4.95e-05	3	142	2	32245948
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	CCT3 CAMSAP3 PIDD1 CPT1B LRRC47 IGSF10 YOD1 DIP2A MOGS PKM STIP1 CFAP57	5.24e-05	736	142	12	29676528
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	FLII PPP1R12A EPB41L3 F5 DENND4C LRRC47 RFLNB MOGS DOCK7 CCAR1 AGK	7.30e-05	645	142	11	25281560
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DNHD1 FLII SRSF1 CCT3 MCM4 CMYA5 EPB41L3 LRRC47 PPP2R2A MOGS RRP12 DOCK7 PKM CCAR1 AGK STIP1 DHX29	7.51e-05	1425	142	17	30948266
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	SRSF1 LEMD2 CAMSAP3 PPP2R2A TNRC18 RRP12 PKM AGK DDX23 MAPK7 SMYD3	8.36e-05	655	142	11	35819319
Pubmed	PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability.	SCAP PKM	9.88e-05	4	142	2	34487377
Pubmed	Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism.	ADGRV1 PCDH15	9.88e-05	4	142	2	18463160
Pubmed	Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor.	CYP11B1 CYP11B2	9.88e-05	4	142	2	19342457
GeneFamily	Cytochrome P450 family 11	CYP11B1 CYP11B2	8.00e-05	3	94	2	1007
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	VCAN NCAN	1.59e-04	4	94	2	574
GeneFamily	Fibronectin type III domain containing	BOC COL20A1 CMYA5 PTPRG EBI3 IGSF9	1.87e-04	160	94	6	555
Coexpression	PEREZ_TP63_TARGETS	KLK15 CXCR3 CYP11B2 CAPN3 APC2 CACHD1 EPB41L3 MROH6 ZNRF3 CNKSR3 ABHD16A	3.79e-06	356	141	11	M10761
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-plasmacytoid_dendritic_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC B3GNT9 SNPH PLXDC1 PIDD1 CMYA5 CDH22 PDZD4	4.38e-08	157	143	8	fc127e7720649e746f3d3f5c2e9e63784767106a
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-plasmacytoid_dendritic_cells\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC B3GNT9 SNPH PLXDC1 PIDD1 CMYA5 CDH22 PDZD4	4.38e-08	157	143	8	66a191cef4aa00811bb04462310d012610006f85
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL20A1 PDK1 IGSF10 KIAA1549L VCAN CNKSR3 INAVA PLOD2	1.31e-07	181	143	8	4e81ec1580e9acb22c32c465eb46f83d1e9e424e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL20A1 PDK1 IGSF10 KIAA1549L VCAN CNKSR3 INAVA PLOD2	1.31e-07	181	143	8	ad30c01290fb98adbd0caed301a584761212c977
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL20A1 PDK1 IGSF10 KIAA1549L VCAN CNKSR3 INAVA PLOD2	1.31e-07	181	143	8	3a3268a4dff8ffcb79e09f46490e138c96f8d916
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	B3GNT9 MCM4 ITIH5 KIAA1549L VCAN IGLON5 SPRN	1.27e-06	169	143	7	335619507857383c3b0b507cdf05d786ed59e585
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPB41L3 ITIH5 CLIP4 VCAN HES7 CFAP57 IL17RD	1.93e-06	180	143	7	c4068fe47408cfd899131a85fa4b7e5908926f94
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	NXN TNRC18 LLGL2 PTPRG ZNRF3 KCNQ1 SMYD3	2.40e-06	186	143	7	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	NXN TNRC18 LLGL2 PTPRG ZNRF3 KCNQ1 SMYD3	2.40e-06	186	143	7	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ACP2 SHB VASH1 EPB41L3 MFNG SORBS3 CD300E	2.49e-06	187	143	7	5917bdfe84cf5941e21b415aebbab3090cc5d576
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)\|Adult / Lineage, Cell type, age group and donor	ST6GALNAC1 CAMSAP3 CACHD1 ADGRV1 SHANK2 PTPRG	1.46e-05	163	143	6	e819a1d6d28290854aa0672b3a18fa9e293d8f23
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Dendritic-conventional_dendritic_cell-DC_c1-CLEC9A\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CXCR3 VASH1 EPB41L3 EBI3 ZNF511 IGLON5	1.57e-05	165	143	6	60b500eb2c10cccf309b8fb28a9119da22d6889c
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITIH5 IGSF10 TTC8 CDH22 PHACTR3 PCDH15	2.56e-05	180	143	6	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCC5 VCAN NCAN PHACTR3 PCDH15 INAVA	2.64e-05	181	143	6	1037051eb82313c13346617b33f3c4c648181c4d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 F5 ITIH5 CLIP4 VCAN PHACTR3	2.64e-05	181	143	6	5f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F B3GNT9 TG NCAN CHRNA10 CD300E	2.64e-05	181	143	6	cd46eba2e03fd15d8de8e875793ae2f51fa98b3b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 F5 ITIH5 CLIP4 VCAN PHACTR3	2.64e-05	181	143	6	c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell	droplet-Marrow-BM-30m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F B3GNT9 TG NCAN CHRNA10 CD300E	2.64e-05	181	143	6	c7d12c7de227c9433ec2303b8929e957b833f59b
ToppCell	facs-Heart-LA-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XIRP1 VTN PPP1R12A CAPN3 CPT1B LLGL2	2.81e-05	183	143	6	8d45dff06a199b1369576657f7f9dc0249c5f841
ToppCell	PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PRSS8 ADGRV1 CLIP4 LLGL2 SHANK2 SLC27A2	2.81e-05	183	143	6	c5b10571599dc26476170b54b53f09c23e6b3117
ToppCell	facs-Heart-LA-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XIRP1 VTN PPP1R12A CAPN3 CPT1B LLGL2	2.81e-05	183	143	6	421265fa15d5a028cb567bb0904e670473ef102b
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ITGA11 B3GNT9 P3H3 EPB41L3 ITIH5 IGLON5	2.98e-05	185	143	6	1b990e3089772be2b38c6d7ea0d1bf22461ae3ea
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-1\|TCGA-Breast / Sample_Type by Project: Shred V9	SEMA3F ATP6AP1 NECAP1 PHKA1 CANT1 SLC27A2	3.17e-05	187	143	6	a716b64ca03d9b61da765bf87f065ac9393303f1
ToppCell	pdx-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	TTC39B CACHD1 ZNRF3 VCAN PKM IL17RD	3.17e-05	187	143	6	7e376831a11ee72ed87abcdac631ca46ae29c250
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADGRV1 EPB41L3 LLGL2 SHANK2 ZNRF3 TJP3	3.17e-05	187	143	6	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PRSS8 CAMSAP3 ADGRV1 LLGL2 SHANK2 SLC27A2	3.36e-05	189	143	6	5d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCell	facs-Lung-nan-3m-Endothelial-Capillary_Aerocyte_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA3F ENDOD1 PLXDC1 MAP3K6 MFNG PTPRG	3.36e-05	189	143	6	09dd2b3d89416192e84abe302a6237b8f3fdcb6e
ToppCell	droplet-Heart-nan-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT9 CMYA5 ITIH5 CLIP4 IGSF10 VCAN	3.46e-05	190	143	6	96a92212ea3fb35fa3d0da495e504edc61c71c23
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	B3GNT9 P3H3 ITIH5 IGSF10 KIAA1549L VCAN	3.67e-05	192	143	6	ad48c941a3ddfd9a5146bafc2209da577bb50531
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC ITGA11 ITIH5 IGSF10 VCAN SPRN	3.67e-05	192	143	6	8937a59f6bbe07f671bdabbd3707dc9c17a14cd9
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC ITGA11 ITIH5 IGSF10 VCAN SPRN	3.67e-05	192	143	6	e4a7f2673f801b008ca67291db2fb2b9fd2955b8
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA11 B3GNT9 P3H3 ITIH5 IGSF10 VCAN	3.67e-05	192	143	6	beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC ITGA11 ITIH5 IGSF10 VCAN SPRN	3.67e-05	192	143	6	ac1477433704573f95111eee6263b93668d2845e
ToppCell	droplet-Bladder-nan-3m\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA11 B3GNT9 P3H3 ITIH5 IGSF10 VCAN	3.78e-05	193	143	6	e55f79bad6888b84b0ad5fccded498b170e3c6dc
ToppCell	droplet-Bladder-nan-3m-Epithelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA11 B3GNT9 P3H3 ITIH5 IGSF10 VCAN	3.89e-05	194	143	6	b294056f9bdc243263cf36dce7b62564144b9de1
ToppCell	facs-GAT-Fat-3m-Mesenchymal-mesenchymal_progenitor\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC P3H3 ITIH5 IGSF10 VCAN PLOD2	4.01e-05	195	143	6	69a29d03e664b72f32d41876510c62345c3aed31
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ST6GALNAC1 ABCC5 ADGRV1 NXN SHANK2 INAVA	4.01e-05	195	143	6	dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCell	facs-GAT-Fat-3m-Mesenchymal\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC P3H3 ITIH5 IGSF10 VCAN PLOD2	4.01e-05	195	143	6	1cffae2b08dbfa1c633ce24023e89b66d28b5431
ToppCell	facs-GAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC P3H3 ITIH5 IGSF10 VCAN PLOD2	4.01e-05	195	143	6	9cef6f18664518060af7c192310dddce6d70345a
ToppCell	droplet-Bladder-nan-3m-Epithelial-bladder_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA11 B3GNT9 P3H3 ITIH5 IGSF10 VCAN	4.12e-05	196	143	6	f47e551ba484687ba6ce8c29a085106131364042
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TTC39B PLXDC1 PDK1 DIP2A LLGL2 NLRC5	4.24e-05	197	143	6	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	PND07-28-samps-Mesenchymal-Matrix_fibroblast-mesenchymal_C\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	LEMD2 PHKA1 CDH22 DOCK7 CHRNA10	4.47e-05	121	143	5	176de42c088988fe1a7838f96add26ee8a30e543
ToppCell	Sepsis-ICU-NoSEP-Myeloid-tDC\|ICU-NoSEP / Disease, condition lineage and cell class	CXCR3 VASH1 EPB41L3 IGSF10 TTC8 MOGS	4.48e-05	199	143	6	90ddd686b8f39c6f6134b9b048396cebcf8d0448
ToppCell	tumor_Lung-Fibroblasts-Myofibroblasts\|Fibroblasts / Location, Cell class and cell subclass	ITGA11 NXN RFLNB VCAN PKM PLOD2	4.48e-05	199	143	6	f89d67e3d8cd48ef5c30a5ad71764f4ebbc8bcb3
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma\|TCGA-Liver / Sample_Type by Project: Shred V9	SEMA3F ATP6AP1 CCT3 LEMD2 CLN6 STIP1	4.61e-05	200	143	6	9cff8be6e566f342fc8b45e93106d033b14759ee
ToppCell	Macroglial-Astrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	CACHD1 ADGRV1 KIAA0319 ZNRF3 NCAN DOCK7	4.61e-05	200	143	6	941536b7c32f1e63c70535233b2ccce0cd7bf96e
ToppCell	Macroglial-Astrocytes-SLC14A1---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	CACHD1 ADGRV1 KIAA0319 ZNRF3 NCAN DOCK7	4.61e-05	200	143	6	d6fcbf4f4bc1b89a9929d7b114c6b907b6979900
ToppCell	Macroglial-Astrocytes-SLC14A1----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	CACHD1 ADGRV1 KIAA0319 ZNRF3 NCAN DOCK7	4.61e-05	200	143	6	f861509b54185d89931db64da1b9d81986cc7938
ToppCell	Control_saline-Mesenchymal_fibroblastic\|Control_saline / Treatment groups by lineage, cell group, cell type	B3GNT9 ITIH5 IGSF10 VCAN PHACTR3 PCDH15	4.61e-05	200	143	6	64ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCell	TCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	FLII ATP6AP1 LEMD2 CANT1 PKM DDX23	4.61e-05	200	143	6	ad2a6da0b1ae7a9212a3c91e5eec4baa7481d8dc
ToppCell	TCGA-Liver-Primary_Tumor\|TCGA-Liver / Sample_Type by Project: Shred V9	SEMA3F ATP6AP1 CCT3 LEMD2 CLN6 STIP1	4.61e-05	200	143	6	b667168081393433597f6ca8baeddba1d1906d40
ToppCell	Macroglial-Astrocytes-SLC14A1\|Macroglial / cells hierarchy compared to all cells using T-Statistic	CACHD1 ADGRV1 KIAA0319 ZNRF3 NCAN DOCK7	4.61e-05	200	143	6	16f468217427921fa18c6d078ffa990eb019b257
ToppCell	TCGA-Bile_Duct-Primary_Tumor\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	FLII ATP6AP1 LEMD2 CANT1 PKM DDX23	4.61e-05	200	143	6	0350e5ffd36033099b7e32a1fdd790fff99790dc
ToppCell	Macroglial-Astrocytes-GFAP---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	ADGRV1 KIAA0319 ZNRF3 NCAN DOCK7 PDZD4	4.61e-05	200	143	6	88d66550781a3c9102ff7455f5cff6fb072943cd
ToppCell	Macroglial-Astrocytes-GFAP-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	ADGRV1 KIAA0319 ZNRF3 NCAN DOCK7 PDZD4	4.61e-05	200	143	6	d6a059b0ef763c281c60b1ac76da6079ea822f80
ToppCell	Macroglial-Astrocytes-GFAP--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	ADGRV1 KIAA0319 ZNRF3 NCAN DOCK7 PDZD4	4.61e-05	200	143	6	16269fa4adb28fc6ed032bbdba8781237dd0d249
ToppCell	Macroglial-Astrocytes-GFAP----L1-2\|Macroglial / cells hierarchy compared to all cells using T-Statistic	ADGRV1 KIAA0319 ZNRF3 NCAN DOCK7 PDZD4	4.61e-05	200	143	6	c6f43bbbd5df5f2c19ae385f1a6b6a330abede2f
ToppCell	Macroglial-Astrocytes-SLC14A1--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	CACHD1 ADGRV1 KIAA0319 ZNRF3 NCAN DOCK7	4.61e-05	200	143	6	0442894c39eec69850c090957a5dc7bcecd21e04
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts\|Control_saline / Treatment groups by lineage, cell group, cell type	B3GNT9 ITIH5 IGSF10 VCAN PHACTR3 PCDH15	4.61e-05	200	143	6	a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCell	Macroglial-Astrocytes-GFAP\|Macroglial / cells hierarchy compared to all cells using T-Statistic	ADGRV1 KIAA0319 ZNRF3 NCAN DOCK7 PDZD4	4.61e-05	200	143	6	79634b1086934412ae92f259ab43554ce545008f
ToppCell	Macroglial-Astrocytes-SLC14A1-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	CACHD1 ADGRV1 KIAA0319 ZNRF3 NCAN DOCK7	4.61e-05	200	143	6	01819446deeab9054f5cfe889d53bb49d137dbc0
ToppCell	COVID_vent\|World / Disease condition, Lineage, Cell class and subclass	CCT3 MCM4 F5 VCAN PKM STIP1	4.61e-05	200	143	6	1d88e5cc4534073f27a7562e1c4b884bd67f09d9
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D231\|Adult / Lineage, Cell type, age group and donor	ADGRV1 TTBK1 LLGL2 SHANK2 CHRNA10	6.76e-05	132	143	5	8d30b71776f5f6da55dc78e0c5cb27be460004e3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 F5 KIAA0319 ZNF511 PLOD2	1.12e-04	147	143	5	989a48bda98fbff398985397a6b1189a4cbc80e7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 F5 KIAA0319 ZNF511 PLOD2	1.12e-04	147	143	5	f6681c849c4c06154548bd29a094f202d1c946c2
ToppCell	10x5'-bone_marrow-Myeloid_Monocytic-Cycling_mono\|bone_marrow / Manually curated celltypes from each tissue	SEMA3F F5 RFLNB VCAN PKM	1.16e-04	148	143	5	de35eeefad0e27a0d127e2e4bedead2bddb75152
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_4\|390C / Donor, Lineage, Cell class and subclass (all cells)	ARHGEF18 F5 TG TTBK1 EBI3	1.40e-04	154	143	5	a90c4c45685eae8d21d03479cfd5a23f6ed3ca07
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	EPB41L3 VCAN KCNQ1 PLOD2 CD300E	1.40e-04	154	143	5	c6ecc46b99a783373729f7fae0b23216148ffb78
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 ADGRV1 CMYA5 PHACTR3 NLRC5	1.44e-04	155	143	5	c58a5fb8d853f12204e961d633e83452eb12a659
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 ADGRV1 CMYA5 PHACTR3 NLRC5	1.44e-04	155	143	5	9cb8c42c2e451b2d4dcd7154a4b1bfd21bbb7ea8
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	KATNB1 VASH1 MROH6 PCDH15 ABHD16A	1.48e-04	156	143	5	5b2781d38a83b4b0f8a53cf321ce5db3a07d0818
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	KATNB1 VASH1 MROH6 PCDH15 ABHD16A	1.48e-04	156	143	5	e0aef6104be16b12304b8e30358f444c1660e92f
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Hsd11b1_Endou\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BOC HTR1A PLXDC1 PCDH15 IGSF9	1.58e-04	158	143	5	c8af8964a140acb2987e3b4906d72c546108d229
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPB41L3 VCAN PKP2 PLOD2 CD300E	1.62e-04	159	143	5	210ac7fa89514a84f38d9f42254e38fbc2bc5f42
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ST6GALNAC1 TTC39B CXCR3 AP5M1 IGSF9	1.67e-04	160	143	5	8308ca6f37986c526432a0fbc5f7ec2e75cfb6d7
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CXCR3 MCM4 TG PKM PCYT1B	1.67e-04	160	143	5	ec81814f3a475ba9bc049cb793bf93bc0b650d37
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-AT1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPB41L3 LLGL2 SHANK2 INAVA PLOD2	1.72e-04	161	143	5	1e17a993126e1f2a25ee7dfbb95a74ccb2a26791
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SHB CMYA5 SSTR4 LLGL2 CNKSR3	1.77e-04	162	143	5	58da6bc04cdac0002b0e6a751c96ff95e1a7f70f
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Sla\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SHB CMYA5 SSTR4 LLGL2 CNKSR3	1.77e-04	162	143	5	4d13c271b4f63cf32980e5643b5d5951165fe8b5
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	PRSS8 MAP3K6 PTPRG CD300E SLC27A2	1.77e-04	162	143	5	2259e9536147e9cdee772e3a30ba7d104573262c
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ARHGEF18 F5 TG TTBK1 EBI3	1.82e-04	163	143	5	bca9abd02ffb2a90c8386a59f5e25126ae7b6acd
ToppCell	LPS-IL1RA-Unknown-Endothelial-Monocytes-Macrophages\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SNPH PIDD1 KIAA0319 RFLNB PLOD2	1.82e-04	163	143	5	6b11a3ada8725670d0489f404c8c2175ad3904e9
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Brinp3\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SHB CMYA5 SSTR4 LLGL2 CNKSR3	1.82e-04	163	143	5	b0aa4a620bd58011225b42ea6dda04e3101ba342
ToppCell	facs-Liver-Non-hepatocytes-24m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 PPP1R12A CMYA5 TG NLRC5	2.10e-04	168	143	5	1254c66f0cd53ef3b913933c0b0648d091da07e9
ToppCell	Children_(3_yrs)-Immune-enucleated_erythrocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SNPH P3H3 JAK3 PKP2 PCYT1B	2.10e-04	168	143	5	8f0c4dfad9f6fed9dcc31795abfe77758ceb46a1
ToppCell	BAL-Control-cDC_6\|Control / Compartment, Disease Groups and Clusters	CCT3 CAPN3 ARHGEF18 IGLON5 SLC27A2	2.10e-04	168	143	5	65ec473cff748b334c0a66e33bc34a8465fe7631
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GPR149 VCAN ZAR1 PKP2 PCDH8	2.10e-04	168	143	5	db56464b946ef9795bc41ed1099c864d49bd8900
ToppCell	droplet-Spleen-nan-21m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNPH PLXDC1 CAMSAP3 IGSF9 PDZD4	2.15e-04	169	143	5	7962165cab84af73d20b56eb70b1ed87c94025ef
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Basal_1\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	ST6GALNAC1 LRRC47 SHANK2 INAVA CFAP57	2.21e-04	170	143	5	aabe993c9f337b1caaeb0e64626a3920579c41b7
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B3GNT9 PRSS8 TG GGACT CHRNA10	2.47e-04	174	143	5	cdfc50e5383c8670ce5109736aff36406f46c03d
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	MCM4 CACHD1 ADGRV1 KIAA0319 INAVA	2.53e-04	175	143	5	fd8b5b756f3df4a04938785f3d9edbb6f1cd20f6
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|368C / Donor, Lineage, Cell class and subclass (all cells)	MCM4 CACHD1 ADGRV1 KIAA0319 INAVA	2.53e-04	175	143	5	36c140540497bbe1c5f08fac2d94f08cac18fabb
ToppCell	LPS-IL1RA+antiTNF\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPB41L3 ITIH5 IGSF10 SHANK2 PLOD2	2.67e-04	177	143	5	b7fee75de7e96924af488a5baa2334711889ae7c
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BOC NXN ITIH5 PTPRG VCAN	2.67e-04	177	143	5	bd602db857f37869ef76d14c05ef522c509f08ee
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1-P1_2\|Striatum / BrainAtlas - Mouse McCarroll V32	COL20A1 VASH1 CNKSR3 INAVA	2.80e-04	98	143	4	7a62a77ca83153dacff4d02d6e32104227d0980d
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr-Polydendrocye.Tnr.Pdgfa_(Pdgfa)\|Striatum / BrainAtlas - Mouse McCarroll V32	COL20A1 VASH1 CNKSR3 INAVA	2.80e-04	98	143	4	26250ea4171a0557a67505839cf79d3fe4d9d41a
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr\|Striatum / BrainAtlas - Mouse McCarroll V32	COL20A1 VASH1 CNKSR3 INAVA	2.80e-04	98	143	4	42875d16ae9fcbaf988cd71be82568f2f862f2dd
ToppCell	COVID-19_Convalescent-PLT_1\|World / Disease Group and Platelet Clusters	POM121 PTPRG CANT1 SORBS3 ABHD16A	2.81e-04	179	143	5	d0f2764c6fc5d61fd69e9231b3603a80ac373f65
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_3\|356C / Donor, Lineage, Cell class and subclass (all cells)	CXCR3 ZDHHC18 F5 ITIH5 KCNQ1	2.81e-04	179	143	5	f378307eb20f002450c748b7be2289d6db2fcbcb
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-hematologic-hematopoietic_progenitor\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MCM4 PKLR PLOD2 PCDH8 PCYT1B	2.88e-04	180	143	5	f598bb9df0d784120847fada2d9a2a88b8b68cd1
Drug	AC1L1CO8	BOC MCM4 TG PKLR PKM	6.53e-06	43	140	5	CID000001987
Drug	thiourea	BOC XIRP1 ATP6AP1 TG SHANK2 PKLR PKM	1.45e-05	128	140	7	CID002723790
Drug	Nalidixic acid sodium salt hydrate; Down 200; 14.6uM; HL60; HT_HG-U133A	SEMA3F FLII ZDHHC18 PIDD1 CPT1B DIP2A VCAN SORBS3	2.85e-05	195	140	8	2336_DN
Drug	methylglyoxal bis(guanylhydrazone	VTN ATP6AP1 SHB PKM TAF7	3.69e-05	61	140	5	CID000009991
Drug	2-Phosphoglycolic Acid	PKLR PKM	3.75e-05	2	140	2	DB02726
Drug	cyadox	CYP11B1 CYP11B2	3.75e-05	2	140	2	ctd:C020728
Drug	N-methyltaurine	PKLR PKM	3.75e-05	2	140	2	CID000007882
Drug	NPCMD	PKLR PKM	3.75e-05	2	140	2	CID000126341
Drug	BW A440C	PKLR PKM	3.75e-05	2	140	2	CID003086296
Drug	6-chloro-2-benzoxazolone	BOC TG	3.75e-05	2	140	2	CID000029858
Drug	18-hydroxydeoxycorticosterone	CYP11B1 CYP11B2	3.75e-05	2	140	2	ctd:C042509
Drug	3-(fluoromethyl)phosphoenolpyruvate	PKLR PKM	3.75e-05	2	140	2	CID006443899
Drug	tert-butoxycarbonyl-tyrosine	BOC VCAN	3.75e-05	2	140	2	CID000100117
Drug	SENP	PKLR PKM	3.75e-05	2	140	2	CID003082911
Drug	8-BDB-TATP	PKLR PKM	3.75e-05	2	140	2	CID003082732
Drug	AC1Q6SAF	PKLR PKM	3.75e-05	2	140	2	CID000194977
Drug	Adenosine 5'-monophosphate 1-oxide	PKLR PKM	3.75e-05	2	140	2	CID000492161
Drug	phenylurethane	SHB PKLR PKM	4.81e-05	12	140	3	CID000007591
Disease	3-hydroxyanthranilate 3,4-dioxygenase measurement	VTN CYP11B1 CYP11B2	1.54e-05	11	136	3	EFO_0021862
Disease	Glucocorticoid-remediable aldosteronism	CYP11B1 CYP11B2	2.11e-05	2	136	2	C1260386
Disease	adrenal cortical adenoma (is_marker_for)	CYP11B1 CYP11B2	2.11e-05	2	136	2	DOID:0050891 (is_marker_for)
Disease	response to acetylsalicylate	SCAP CNKSR3 KCNQ1	5.13e-05	16	136	3	GO_1903492
Disease	centromere protein W measurement	ENDOD1 VTN	6.31e-05	3	136	2	EFO_0802387
Disease	congenital adrenal hyperplasia (implicated_via_orthology)	CYP11B1 CYP11B2	6.31e-05	3	136	2	DOID:0050811 (implicated_via_orthology)
Disease	complement factor H-related protein 1 measurement	VTN CYP11B1 CYP11B2 KIAA1549L	1.32e-04	56	136	4	EFO_0600054
Disease	primary hyperaldosteronism (is_implicated_in)	CYP11B1 CYP11B2	2.09e-04	5	136	2	DOID:446 (is_implicated_in)
Disease	level of carboxypeptidase N subunit 2 in blood serum	VTN CYP11B2	2.09e-04	5	136	2	OBA_2041122
Disease	interleukin-27 measurement	CYP11B1 EBI3	3.13e-04	6	136	2	EFO_0010916
Disease	Conn Syndrome	CYP11B1 CYP11B2	3.13e-04	6	136	2	C1384514
Disease	torsin-1A-interacting protein 1 measurement	VTN F5	3.13e-04	6	136	2	EFO_0802137
Disease	Hyperaldosteronism	CYP11B1 CYP11B2	3.13e-04	6	136	2	C0020428
Disease	cholesteryl esters to total lipids in large LDL percentage	TTC39B DOCK7 NLRC5	3.92e-04	31	136	3	EFO_0022249
Disease	peripheral vascular disease	F5 KIAA1549L	4.36e-04	7	136	2	EFO_0003875
Disease	protocadherin alpha-7 measurement	CYP11B1 CYP11B2	4.36e-04	7	136	2	EFO_0801973
Disease	E3 ubiquitin-protein ligase RNF13 measurement	VTN F5	5.80e-04	8	136	2	EFO_0801556
Disease	interleukin 27 receptor subunit alpha measurement	CYP11B1 EBI3	5.80e-04	8	136	2	EFO_0008183
Disease	calpastatin measurement	VTN CYP11B1	5.80e-04	8	136	2	EFO_0008065
Disease	tyrosine-protein kinase JAK2 measurement	VTN CYP11B2	5.80e-04	8	136	2	EFO_0020825
Disease	protein FAM163B measurement	CYP11B1 CYP11B2	7.43e-04	9	136	2	EFO_0802936
Disease	phospholipid measurement, high density lipoprotein cholesterol measurement	TTC39B ZDHHC18 VTN CDH22 NCAN DOCK7 NLRC5	7.45e-04	321	136	7	EFO_0004612, EFO_0004639
Disease	very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	TTC39B VTN ACP2 CAPN3 DOCK7 NLRC5	8.68e-04	239	136	6	EFO_0008317, EFO_0020945
Disease	cup-to-disc ratio measurement	TRIOBP EPB41L3 F5 MFNG KIAA1549L ZNRF3 VCAN CCAR1	8.86e-04	430	136	8	EFO_0006939
Disease	androstenedione measurement	CYP11B1 CYP11B2	9.26e-04	10	136	2	EFO_0007972
Disease	WNT1-inducible-signaling pathway protein 1 measurement	VTN TG	9.26e-04	10	136	2	EFO_0008321
Disease	fatty acid measurement	TTC39B SFSWAP CAPN3 NCAN PHACTR3 DOCK7 PLOD2 IGLON5	9.68e-04	436	136	8	EFO_0005110
Disease	cell growth regulator with EF hand domain protein 1 measurement	CYP11B1 CYP11B2	1.13e-03	11	136	2	EFO_0801461
Disease	cholesteryl esters to total lipids in small VLDL percentage	TTC39B DOCK7 NLRC5	1.51e-03	49	136	3	EFO_0022256
Disease	T-cell surface glycoprotein CD3 epsilon chain measurement	VTN F5	1.59e-03	13	136	2	EFO_0802114
Disease	hypothyroidism (implicated_via_orthology)	TG PHKA1	1.59e-03	13	136	2	DOID:1459 (implicated_via_orthology)
Disease	thrombosis (is_implicated_in)	VTN F5	2.13e-03	15	136	2	DOID:0060903 (is_implicated_in)
Disease	Congenital total cataract	LEMD2 AGK	2.43e-03	16	136	2	C0266539
Disease	neutrophil collagenase measurement	VTN CYP11B1	2.43e-03	16	136	2	EFO_0008248
Disease	calcium/calmodulin-dependent protein kinase type 1 measurement	CYP11B1 F5	2.43e-03	16	136	2	EFO_0008062
Disease	total lipids in medium HDL measurement	TTC39B VTN NLRC5	2.46e-03	58	136	3	EFO_0022310
Disease	free cholesterol in medium HDL measurement	TTC39B VTN NLRC5	2.46e-03	58	136	3	EFO_0022267
Disease	cholesterol to total lipids in medium HDL percentage	TTC39B DOCK7 NLRC5	2.71e-03	60	136	3	EFO_0022237
Disease	phospholipids in HDL measurement	TTC39B VTN NLRC5	2.84e-03	61	136	3	EFO_0022293
Disease	Disorder of eye	ADGRV1 TTC8 VCAN PCDH15 CLN6	3.07e-03	212	136	5	C0015397
Disease	total lipids in HDL measurement	TTC39B VTN NLRC5	3.11e-03	63	136	3	EFO_0022307
Disease	very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio	TTC39B VTN CAPN3 DOCK7 NLRC5	3.74e-03	222	136	5	EFO_0008317, EFO_0020943
Disease	phospholipid measurement	TTC39B VTN NCAN DOCK7	4.08e-03	140	136	4	EFO_0004639
Disease	phospholipids:total lipids ratio	TTC39B VTN NCAN DOCK7 NLRC5	4.11e-03	227	136	5	EFO_0020946
Disease	Malignant neoplasm of breast	KLK15 BOC XIRP1 SRSF1 APC2 TRMT11 EPB41L3 MAP3K6 LLGL2 NLRC5 PCDH8 PDZD4	4.14e-03	1074	136	12	C0006142
Disease	disease of metabolism (implicated_via_orthology)	PKLR PKM	4.18e-03	21	136	2	DOID:0014667 (implicated_via_orthology)
Disease	lipid measurement, high density lipoprotein cholesterol measurement	TTC39B VTN CDH22 NCAN DOCK7 NLRC5	4.36e-03	330	136	6	EFO_0004529, EFO_0004612
Disease	hemoglobin change measurement	PPP2R2A CNKSR3	4.59e-03	22	136	2	EFO_0600027
Disease	portal hypertension (biomarker_via_orthology)	VASH1 F5	4.59e-03	22	136	2	DOID:10762 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
VPEYALPVLTFVRRS	PTPRG	1031	P23470
EPYPDVTFTLLLRRR	CHRNA10	221	Q9GZZ6
ATQLYRRGPPARVTL	CXCR3	156	P49682
VPRLREPRDLYGVSS	AGBL3	66	Q8NEM8
EETPVQRPSLYRRIL	AGK	266	Q53H12
YAERPEVARRDSAPT	ARHGEF18	1191	Q6ZSZ5
LADQTVRYPIRAPRV	VCAN	201	P13611
GRYRDPTTVTTLRVP	PPP2R2A	141	P63151
SPRRVRRVVPRYTVQ	CCAR1	351	Q8IX12
DLVRVYVSPAITTPR	CD300E	121	Q496F6
IYRERDSERAPASVP	ABHD16A	16	O95870
IIYVPLPDAATRREI	SPATA5	791	Q8NB90
RIYAAEPRIIPQTSL	ADGRV1	5841	Q8WXG9
REPRVNLTFRTVYPD	ALKBH3	266	Q96Q83
EHRSRPIYVSTVRPQ	CACHD1	211	Q5VU97
TIVATRHYRPPEVIL	CLK3	481	P49761
VRRDPSIPIYGLRQS	C22orf31	6	O95567
EEIRSYRAPPESVVR	DNHD1	3241	Q96M86
RVYLRETTLITPFPV	DHX29	1281	Q7Z478
RYGIFAPPSRVQRVT	CLIP4	541	Q8N3C7
AAPAQPSIRYRKDRV	CAMSAP3	201	Q9P1Y5
PSLIRAGSRVAYRPI	ATP5MC3	11	P48201
RSLIPRYIRDSAAAV	RAB6C	76	Q9H0N0
RSLIPRYIRDSAAAV	RAB6D	76	Q53S08
AYEPVQRPSFRAVIR	JAK3	761	P52333
RVRTLTQAYFSPERP	P3H3	541	Q8IVL6
YVRETLPVLTRTVVP	YOD1	141	Q5VVQ6
YSTAPRPRVETSRAV	PDK1	336	Q15118
TGIYRAVPIRVNPRV	MCM4	391	P33991
AERVRAYIQSLPPRQ	MAPK7	291	Q13164
SLDPRVSIYSTRRPV	KCNQ1	86	P51787
TRVPECLYTLPSLRR	FLII	236	Q13045
STYTAALPRERLRPR	IL17RD	341	Q8NFM7
TIYAFSLRVPPAERR	LLGL2	741	Q6P1M3
VPRVRTDYVVRPSTG	NFRKB	501	Q6P4R8
PERSYLEITPSRVIL	ITIH5	751	Q86UX2
AYPARPAQLRRRASV	LEMD2	121	Q8NC56
AEVYPIRVQPARILS	PHKA1	466	P46020
LTVRVSPEVRDVRPY	LRRC47	321	Q8N1G4
YRESREIRIPVDPQS	CFAP57	316	Q96MR6
APLRRIYERPSTTCS	KATNB1	331	Q9BVA0
PQRTPAGIRYRIAVI	CANT1	96	Q8WVQ1
TRDRIPVYSAFRAPR	ENDOD1	71	O94919
RSRPLSVVYVLTREP	MAP3K6	41	O95382
QARLGTPADRPVRVY	PCYT1B	66	Q9Y5K3
LRTTSRVIPHPRYEA	KLK15	86	Q9H2R5
PLRTVRPYTVRVGDE	PCDH8	476	O95206
LERVGPESSPYLSRR	PDZD4	556	Q76G19
VARYRPRAPIIAVTR	PKM	441	P14618
RYRPRAAVIAVTRSA	PKLR	486	P30613
RARGRTLEPYPLVIA	GGACT	31	Q9BVM4
NIDRVPEPRGYSRSR	KIAA1549L	1516	Q6ZVL6
YLRSPQDPLRRAAAV	MROH6	606	A6NGR9
PLCGTVRFSRRYPTV	AP5M1	16	Q9H0R1
TEYRPTPVEEDLRRA	ITGA11	1041	Q9UKX5
PVLPVTATEIRQYLR	TWNK	51	Q96RR1
PAVERLARSYLRRPA	DDX23	611	Q9BUQ8
LEIRPRVSYVNSVPL	OOSP4A	151	A0A2R8YFL7
YVPPILRRATASLDT	NLRC5	176	Q86WI3
FVVKYSPERQRSLRP	PLOD2	651	O00469
YRARRAVTLHSAPPV	MOGS	66	Q13724
ERTPRQRSGYALAIP	GPR149	536	Q86SP6
PPTRARSLRFVTLLY	ACP2	26	P11117
VTVRIAPPDRRFSRS	POM121	271	Q96HA1
IIPSPGYRSVRERTS	ABCC5	11	O15440
PGLPASRVRYRVDDV	PCDH15	956	Q96QU1
VRAPAARPETVKRYA	APC2	2086	O95996
DSRRVLVTVNYPPTI	IGLON5	206	A6NGN9
VTLSVVSYPPRILER	IGSF10	1736	Q6WRI0
VRRSTAEAARIIYPP	BOC	221	Q9BWV1
VKLYPDSRVRPTREI	DOCK7	531	Q96N67
PRPVRLVRVTYVSSE	COL20A1	581	Q9P218
ERAIFRTAPSTPVIR	CMYA5	3796	Q8N3K9
PRVQCRASRYPIAVD	EBI3	31	Q14213
TRAARVPRTVLPFEA	CYP11B1	26	P15538
SQRIFITYRRAPPVR	DENND4C	136	Q5VZ89
PIDYVNKRTPRRAAA	HTR1A	141	P08908
RRPAAVLYAQPSERS	C1QTNF8	186	P60827
TRAARAPRTVLPFEA	CYP11B2	26	P19099
VTARDPDAANRPVRY	CDH22	416	Q9UJ99
YFERPQVASVRSVPR	DIP2A	236	Q14689
FAVGYLRERSRVEPP	HES7	61	Q9BYE0
ERPTRTIIPVQYETR	CAPN3	311	P20807
REVSQRFRLPPSEYV	CAPN3	541	P20807
PTRYERQLAVRPSTP	SCAP	471	Q12770
PRPALIYGRAVVTRT	FAM87A	231	P0C7U9
TPLRYQRLVPSRSRI	INAVA	551	Q3KP66
TRRASALIDRPAPYF	EPB41L3	416	Q9Y2J2
LPVPRVSATIQRYLE	CPT1B	176	Q92523
LARDVYVGRPSLNRP	MFNG	161	O00587
RLLERYRGPEPSDTV	PIDD1	646	Q9HB75
SRVTRELRAAVPGYP	PKN3	251	Q6P5Z2
PVLVIYDSSDRPSRI	IGLV3-32	61	A0A0A0MS00
EYLVSGIRTPPVRRN	PHACTR3	51	Q96KR7
FILRLPPEYASTVRR	TAF7	16	Q15545
EERSVPTAYRVSRSP	SFSWAP	821	Q12872
ITDPPYGIRESTRRT	TRMT11	306	Q7Z4G4
SERRPATPAEVRYIS	SHB	166	Q15464
RPLVVRTGAPYRLTT	SEMA3F	451	Q13275
PRTRTLLSDPTYREL	STIP1	141	P31948
IRISPTRAYNRPTLR	F5	2041	P12259
PPCRSLTRVLVESYR	NXN	206	Q6DKJ4
PRHRPTRFLSTTIVY	RFLNB	156	Q8N5W9
PSYARPRFLRIQDTI	SLC27A2	551	O14975
LSDRTVRYPITQSRP	NCAN	211	O14594
DGSVRYPIQTPRRRC	NCAN	311	O14594
VAVVHPLRAATYRRP	SSTR4	146	P31391
APTRARRTTIYAEPV	ST6GALNAC1	66	Q9NSC7
PYRAVAQALEVIPRT	CCT3	436	P49368
SRPITFSRYIRPICL	PRSS8	141	Q16651
RRRTSPPVSVRDAYG	SNPH	16	O15079
RYPPDSVRLLGRVVF	SMYD3	96	Q9H7B4
APRSRSRELEAVPYL	TRIOBP	101	Q9H2D6
TPAPRRAVLETIRTY	RRP12	706	Q5JTH9
IVPFREAPAYSNRRR	SHANK2	391	Q9UPX8
ARPIRTRASKYYIPE	B3GNT9	261	Q6UX72
YVTRVRPGQRASPRA	B4GALNT4	526	Q76KP1
IERSPRTLPRSITYV	CLN6	101	Q9NWW5
VRYDILPLSPVSRNR	CTDNEP1	41	O95476
PYRFSRPTTERHLVR	CNKSR3	481	Q6P9H4
VAASPAPAGERRIYR	ZNF511	211	Q8NB15
TVRATRASPDPRAYV	TNRC18	446	O15417
EQAIRTPRTAYTARP	TTC8	136	Q8TAM2
SPTTPVRSLRYRRVN	TTBK1	441	Q5TCY1
AVRKARRYSASLPAP	TTC39B	516	Q5VTQ0
ASRVRVRPAQRYGAP	SPRN	46	Q5BIV9
ERAGVRTYVSTIRIP	RLIM	371	Q9NVW2
PASYVQVSREPRLRL	SORBS3	506	O60504
PYTAALTAVRPSRVA	ATP6AP1	216	Q15904
RDATRARLPAYRQPV	IGSF9	1156	Q9P2J2
PYERVVLREASFKRP	TJP3	606	O95049
RVHRTNAIPAYPTRT	ZNRF3	371	Q9ULT6
RYGPPSRRSENRVVV	SRSF1	111	Q07955
SPDVPESRRRSIFEY	PLXDC1	266	Q8IUK5
TPVPERLEAVQRYIR	VASH1	116	Q7L8A9
YVSFRPPTSQRERIA	PJA1	31	Q8NG27
VLSRRVSPGYVPACR	TG	1156	P01266
LRTQVRIPGERTYAP	USP40	1071	Q9NVE5
TRRVDTVDPPYPRSI	VTN	451	P04004
QESRRAALLVPPRYA	PKP2	181	Q99959
AALLVPPRYARSEIV	PKP2	186	Q99959
PPRYARSEIVGVSRA	PKP2	191	Q99959
GRRPVRYCSRVEIPS	XIRP1	676	Q702N8
STYRPPPRTREVLIN	ZDHHC18	171	Q9NUE0
PRTVAVYSPLALRRL	ZAR1	176	Q86SH2
IRSYLTFVLRPVQRP	KIAA0319	96	Q5VV43
GTRLAYVAPTIPRRL	PPP1R12A	491	O14974
DVSVYRIPPRASNRG	NECAP1	16	Q8NC96