Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesspositive regulation of protein binding

WNT5A PPP2CA PPP2CB MFNG SPON1 EP300

1.36e-05851266GO:0032092
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

ZDHHC2 RELN VPS18 PDE4A RAPSN RASGRF2 WNT5A CKAP5 GRIN2A GRM5 NCDN STXBP1 PLCB1 SLC7A10

5.48e-0566312614GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

ZDHHC2 RELN VPS18 PDE4A RAPSN RASGRF2 WNT5A CKAP5 GRIN2A GRM5 NCDN STXBP1 PLCB1 SLC7A10

5.57e-0566412614GO:0099177
GeneOntologyBiologicalProcesspositive regulation of binding

WNT5A PPP2CA PPP2CB GTF2B MFNG SPON1 EP300

8.47e-051701267GO:0051099
GeneOntologyBiologicalProcesssensory perception

OR5P3 CABP1 CABP2 PDE4A DHRS3 OR52L1 RDH10 GRIN2A REST OR2T10 OPRL1 OR6A2 OR52N2 OR2D3 PLCB2 GJA10 OR10G8 CRB2

9.08e-05107212618GO:0007600
GeneOntologyBiologicalProcesspositive regulation of synaptic transmission

ZDHHC2 RELN RAPSN RASGRF2 CKAP5 GRIN2A STXBP1 SLC7A10

9.41e-052331268GO:0050806
MousePhenosyndactyly

PCSK5 FRAS1 B3GLCT WNT5A RDH10 CHUK FBN2

3.62e-0693977MP:0000564
DomainEGF

PCSK5 VLDLR FRAS1 RELN VWDE EGFL6 FBN2 FCGBP MEGF6 NOTCH3 CRB2

5.65e-0723512611SM00181
DomainEGF-like_dom

PCSK5 VLDLR FRAS1 RELN VWDE EGFL6 FBN2 FCGBP MEGF6 NOTCH3 CRB2

9.99e-0724912611IPR000742
DomainhEGF

FBN2 MEGF6 NOTCH3 CRB2

3.57e-05281264PF12661
DomainEGF_Ca-bd_CS

VLDLR EGFL6 FBN2 MEGF6 NOTCH3 CRB2

5.01e-05971266IPR018097
DomainEGF_CA

VLDLR EGFL6 FBN2 MEGF6 NOTCH3 CRB2

5.61e-05991266PS01187
DomainEGF_1

VLDLR LAMB4 RELN VWDE EGFL6 FBN2 MEGF6 NOTCH3 CRB2

5.88e-052551269PS00022
DomainASX_HYDROXYL

VLDLR EGFL6 FBN2 MEGF6 NOTCH3 CRB2

5.94e-051001266PS00010
DomainEGF-like_CS

VLDLR LAMB4 RELN VWDE EGFL6 FBN2 MEGF6 NOTCH3 CRB2

7.03e-052611269IPR013032
DomainEGF_2

VLDLR LAMB4 RELN VWDE EGFL6 FBN2 MEGF6 NOTCH3 CRB2

7.90e-052651269PS01186
DomainEGF-type_Asp/Asn_hydroxyl_site

VLDLR EGFL6 FBN2 MEGF6 NOTCH3 CRB2

8.23e-051061266IPR000152
DomainGrowth_fac_rcpt_

PCSK5 VLDLR FRAS1 EGFL6 FBN2 MEGF6 NOTCH3

9.12e-051561267IPR009030
DomainEF-hand_like

PLCB1 PLCB2 PLCH1

1.29e-04151263PF09279
DomainPI-PLC-Y

PLCB1 PLCB2 PLCH1

1.29e-04151263PF00387
DomainPLCYc

PLCB1 PLCB2 PLCH1

1.29e-04151263SM00149
DomainPLipase_C_Pinositol-sp_Y

PLCB1 PLCB2 PLCH1

1.29e-04151263IPR001711
DomainPIPLC_Y_DOMAIN

PLCB1 PLCB2 PLCH1

1.29e-04151263PS50008
DomainPI-PLC_fam

PLCB1 PLCB2 PLCH1

1.29e-04151263IPR001192
DomainPLC_EF-hand-like

PLCB1 PLCB2 PLCH1

1.29e-04151263IPR015359
DomainREELIN

RELN SPON1

1.35e-0431262PS51019
DomainPLC-beta_C

PLCB1 PLCB2

1.35e-0431262PF08703
DomainReeler_dom

RELN SPON1

1.35e-0431262IPR002861
DomainPLC-beta_C

PLCB1 PLCB2

1.35e-0431262IPR014815
DomainReeler

RELN SPON1

1.35e-0431262PF02014
DomainPost-SET_dom

ASH1L NSD1 SETDB1

1.57e-04161263IPR003616
DomainPostSET

ASH1L NSD1 SETDB1

1.57e-04161263SM00508
DomainPOST_SET

ASH1L NSD1 SETDB1

1.57e-04161263PS50868
DomainEGF_CA

VLDLR EGFL6 FBN2 MEGF6 NOTCH3 CRB2

1.79e-041221266SM00179
DomainEGF-like_Ca-bd_dom

VLDLR EGFL6 FBN2 MEGF6 NOTCH3 CRB2

1.95e-041241266IPR001881
DomainEGF_3

VLDLR RELN VWDE EGFL6 FBN2 MEGF6 NOTCH3 CRB2

1.96e-042351268PS50026
DomainPI-PLC-X

PLCB1 PLCB2 PLCH1

2.27e-04181263PF00388
DomainPLCXc

PLCB1 PLCB2 PLCH1

2.27e-04181263SM00148
DomainPIPLC_X_DOMAIN

PLCB1 PLCB2 PLCH1

2.68e-04191263PS50007
DomainPLipase_C_PInositol-sp_X_dom

PLCB1 PLCB2 PLCH1

2.68e-04191263IPR000909
DomainPLC-beta

PLCB1 PLCB2

2.69e-0441262IPR016280
DomainCa-bd_2

CABP1 CABP2

2.69e-0441262IPR015754
DomainEGF_CA

VLDLR EGFL6 FBN2 MEGF6 NOTCH3

2.90e-04861265PF07645
DomainAWS

ASH1L NSD1

4.46e-0451262SM00570
DomainAWS

ASH1L NSD1

4.46e-0451262PS51215
DomainAWS_dom

ASH1L NSD1

4.46e-0451262IPR006560
DomainFringe-like

B3GLCT MFNG

4.46e-0451262IPR003378
DomainFringe

B3GLCT MFNG

4.46e-0451262PF02434
Domain-

PLCB1 PLCB2 PLCH1

6.19e-042512633.20.20.190
DomainPLC-like_Pdiesterase_TIM-brl

PLCB1 PLCB2 PLCH1

6.19e-04251263IPR017946
PathwayKEGG_MEDICUS_REFERENCE_TRH_TRHR_PLCB_PKC_SIGNALING_PATHWAY

TSHB PLCB1 PLCB2

7.49e-05121013M47649
PathwayKEGG_MEDICUS_REFERENCE_TSH_DUOX2_TG_SIGNALING_PATHWAY

TSHB PLCB1 PLCB2

7.49e-05121013M47628
PathwayKEGG_WNT_SIGNALING_PATHWAY

WNT5A WNT2B PPP2CA PPP2CB PLCB1 PLCB2 EP300

1.04e-041511017M19428
PathwayKEGG_LONG_TERM_DEPRESSION

GRM5 PPP2CA PPP2CB PLCB1 PLCB2

1.43e-04701015M8232
PathwayKEGG_LONG_TERM_POTENTIATION

GRIN2A GRM5 PLCB1 PLCB2 EP300

1.43e-04701015M3115
PathwayWP_GPR40_PATHWAY

PLCB1 PLCB2 PLCH1

1.53e-04151013M39526
PathwayREACTOME_OPIOID_SIGNALLING

PDE4A PPP2CA PPP2CB PLCB1 PLCB2

1.53e-04711015MM14491
PathwayREACTOME_DARPP_32_EVENTS

PDE4A PPP2CA PPP2CB

1.87e-04161013MM14699
PathwayREACTOME_INOSITOL_PHOSPHATE_METABOLISM

IP6K3 PLCB1 PLCB2 PLCH1

3.79e-04481014M26964
PathwayREACTOME_INOSITOL_PHOSPHATE_METABOLISM

IP6K3 PLCB1 PLCB2 PLCH1

3.79e-04481014MM14589
PathwayREACTOME_SIGNALING_BY_NTRKS

PCSK5 SH3GL2 REST PPP2CA PPP2CB EP300

3.99e-041341016M3574
PathwayREACTOME_OPIOID_SIGNALLING

PDE4A PPP2CA PPP2CB PLCB1 PLCB2

4.64e-04901015M6467
PathwayREACTOME_SIGNALING_BY_GPCR

PDE4A RASGRF2 WNT5A WNT2B HCAR1 OBSCN TSHB GRM5 OPRL1 PPP2CA PPP2CB CXCR6 PLCB1 PLCB2

4.66e-0470210114M746
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

GRM5 PLCB1 PLCB2

4.98e-04221013M47690
PathwayKEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY

GRM5 PLCB1 PLCB2

4.98e-04221013M47675
PathwayREACTOME_REELIN_SIGNALLING_PATHWAY

VLDLR RELN

5.01e-0451012M27759
PathwayREACTOME_REELIN_SIGNALLING_PATHWAY

VLDLR RELN

5.01e-0451012MM15504
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

GRM5 PLCB1 PLCB2

5.70e-04231013M47676
PathwayREACTOME_DARPP_32_EVENTS

PDE4A PPP2CA PPP2CB

6.48e-04241013M751
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAQ_PLCB_G_CALCINEURIN_SIGNALING_PATHWAY

PLCB1 PLCB2

7.48e-0461012M47548
PathwayWP_WNT_SIGNALING_AND_PLURIPOTENCY

WNT5A WNT2B PPP2CA PPP2CB EP300

7.86e-041011015M39387
PathwayKEGG_MELANOGENESIS

WNT5A WNT2B PLCB1 PLCB2 EP300

7.86e-041011015M7761
PathwayWP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY

WNT5A WNT2B PPP2CA PPP2CB EP300

7.86e-041011015MM15829
PathwayREACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL

PLCB1 PLCB2 PLCH1

8.23e-04261013M27053
PathwayWP_SIDS_SUSCEPTIBILITY_PATHWAYS

REST RYR2 KCNH2 EP300

8.35e-04591014MM15838
PathwayREACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION

REST PPP2CA PPP2CB EP300

9.47e-04611014M152
PathwayREACTOME_SYNTHESIS_OF_IP3_AND_IP4_IN_THE_CYTOSOL

PLCB1 PLCB2 PLCH1

1.03e-03281013MM14711
PathwayPID_REELIN_PATHWAY

VLDLR RELN GRIN2A

1.03e-03281013M69
PathwayBIOCARTA_REELIN_PATHWAY

VLDLR RELN

1.04e-0371012MM1566
PathwayBIOCARTA_REELIN_PATHWAY

VLDLR RELN

1.04e-0371012M22049
PathwayREACTOME_PP2A_MEDIATED_DEPHOSPHORYLATION_OF_KEY_METABOLIC_FACTORS

PPP2CA PPP2CB

1.04e-0371012M26992
PathwayKEGG_MEDICUS_REFERENCE_CASR_PTH_SIGNALING_PATHWAY

PLCB1 PLCB2

1.04e-0371012M47505
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

PPP2CA PPP2CB STXBP1 PLCB1 PLCB2

1.06e-031081015M17034
PathwayREACTOME_G_ALPHA_I_SIGNALLING_EVENTS

PDE4A HCAR1 OPRL1 PPP2CA PPP2CB CXCR6 PLCB1 PLCB2

1.10e-032891018MM15057
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DDR1 CPAMD8 SLC16A9 DHRS3 UACA CARMIL1 SHB ASH1L RDH10 OBSCN AHCYL2 PLD3 CDC42BPB NCDN NIT2 OPRL1 ARFGEF3 ATP2C1 MEGF6 XPNPEP3 EP300 NOTCH3

2.60e-0814891282228611215
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

PCSK5 CABP1 DNAH10 NSD1 CDC42BPB ADAMTS12 PPP2CA ATP2C1 KCNH2 CPNE3 PLCB1 PLCB2 ATP1A1 EP300 PLXNA1

8.65e-087301281534857952
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

KDM5A SHB ASH1L HKDC1 AHCYL2 LYST RYR2 CHUK ADAMTS12 PPP2CA PPP2CB MFNG STXBP1 ATP1A1 OR10G8 PLCH1 ZBTB11 DNAH6 VARS1 FCMR

3.31e-0714421282035575683
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

PDE4A UACA ZNRD2 KDM5A SH3GL2 CKAP5 NSD1 GRIN2A GRM5 CDC42BPB NCDN PPP2CB WDR45 KLHL7 PLCB1 DNMT1

5.45e-079631281628671696
Pubmed

New nomenclature for chromatin-modifying enzymes.

KDM5A ASH1L NSD1 SETDB1 EP300

2.24e-0657128518022353
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ENGASE PCSK5 FRAS1 PDE4A SPEG RDH10 OBSCN NSD1 LYST CDC42BPB PPP2CB MEGF6 KCNH2 HMGXB3 EP300 PLXNA1

3.23e-0611051281635748872
Pubmed

mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia.

GRIN2A GRM5 NCDN

4.02e-069128330214040
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

VLDLR RELN KDM5A PEG3 ASH1L CKAP5 CDC42BPB CHUK SETDB1 STXBP1 TTC7B KLHL7 ZBTB11 VARS1 EP300 SEZ6L DNMT1

5.16e-0612851281735914814
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

KDM5A NSD1 EP300 DNMT1

6.59e-0633128426864203
Pubmed

Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway.

RELN WNT5A WNT2B

1.05e-0512128311719201
Pubmed

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.

PCSK5 CPAMD8 RELN SH3GL2

1.30e-0539128419010793
Pubmed

Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.

PPP2CA PPP2CB

1.34e-05212822555176
Pubmed

Association analysis of polymorphic CGG repeat in 5' UTR of the reelin and VLDLR genes with schizophrenia.

VLDLR RELN

1.34e-052128212363388
Pubmed

Regulation of spindle formation by active mitogen-activated protein kinase and protein phosphatase 2A during mouse oocyte meiosis.

PPP2CA PPP2CB

1.34e-052128211751260
Pubmed

Identification of predicted human outer dynein arm genes: candidates for primary ciliary dyskinesia genes.

DNAH10 DNAH6

1.34e-052128215937072
Pubmed

The antagonistically bifunctional retinoid oxidoreductase complex is required for maintenance of all-trans-retinoic acid homeostasis.

DHRS3 RDH10

1.34e-052128228232491
Pubmed

Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation.

SPEG RYR2

1.34e-052128232683896
Pubmed

PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex.

GRM5 PLCB1

1.34e-052128211224545
Pubmed

Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner.

PLD3 PLCB2

1.34e-052128219525236
Pubmed

Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart.

PPP2CA PPP2CB

1.34e-052128211113010
Pubmed

Structure and expression of Wnt13, a novel mouse Wnt2 related gene.

WNT2B TSHB

1.34e-05212829545553
Pubmed

Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases.

SPEG OBSCN

1.34e-052128215185077
Pubmed

Cholesterol regulates HERG K+ channel activation by increasing phospholipase C β1 expression.

KCNH2 PLCB1

1.34e-052128223793622
Pubmed

The role of protein phosphatase 2A catalytic subunit Calpha in embryogenesis: evidence from sequence analysis and localization studies.

PPP2CA PPP2CB

1.34e-052128210543450
Pubmed

Tau pathology involves protein phosphatase 2A in parkinsonism-dementia of Guam.

GRM5 PPP2CA

1.34e-052128224395787
Pubmed

Wnt2b and Wnt5a expression is highly associated with M2 TAMs in non‑small cell lung cancer.

WNT5A WNT2B

1.34e-052128236102318
Pubmed

Lack of CaBP1/Caldendrin or CaBP2 Leads to Altered Ganglion Cell Responses.

CABP1 CABP2

1.34e-052128227822497
Pubmed

Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities.

PPP2CA PPP2CB

1.34e-052128234902541
Pubmed

Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes.

PPP2CA PPP2CB

1.34e-05212822837763
Pubmed

The catalytic subunit of protein phosphatase 2A (PP2Ac) promotes DNA hypomethylation by suppressing the phosphorylated mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)/phosphorylated ERK/DNMT1 protein pathway in T-cells from controls and systemic lupus erythematosus patients.

PPP2CA DNMT1

1.34e-052128223775084
Pubmed

Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes.

PPP2CA PPP2CB

1.34e-05212821846293
Pubmed

Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling.

GRM5 NCDN

1.34e-052128220007903
Pubmed

PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte.

PPP2CA PPP2CB

1.34e-052128227096707
Pubmed

Functions of CaBP1 and CaBP2 in the peripheral auditory system.

CABP1 CABP2

1.34e-052128229661613
Pubmed

RELN and VLDLR mutations underlie two distinguishable clinico-radiological phenotypes.

VLDLR RELN

1.34e-052128227000652
Pubmed

Common genetic variation and the control of HIV-1 in humans.

DDR1 GRIN2A GRM5 HMGXB3

1.44e-0540128420041166
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

FRAS1 SPEG PEG3 CKAP5 AHCYL2 NCDN ARFGEF3 SETDB1 SEZ6L

2.11e-05407128912693553
Pubmed

Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.

RELN GRIN2A GRM5 KCNH2

2.32e-0545128425979088
Pubmed

Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway.

PLCB1 PLCB2 PLCH1

3.82e-051812831979339
Pubmed

Reelin together with ApoER2 regulates interneuron migration in the olfactory bulb.

VLDLR RELN

4.02e-053128223209795
Pubmed

A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q.

PLCB1 PLCB2

4.02e-053128211753430
Pubmed

DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures.

RELN DNMT1

4.02e-053128215671176
Pubmed

Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice.

GRM5 NCDN

4.02e-053128226195764
Pubmed

Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices.

GRM5 PLCB1

4.02e-053128212364493
Pubmed

Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse.

VLDLR RELN

4.02e-053128218778775
Pubmed

Suppression of PLCbeta2 by endotoxin plays a role in the adenosine A(2A) receptor-mediated switch of macrophages from an inflammatory to an angiogenic phenotype.

PLCB1 PLCB2

4.02e-053128219850892
Pubmed

Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development.

RELN WNT2B

4.02e-053128235652101
Pubmed

Role of members of the Wnt gene family in human hematopoiesis.

WNT5A WNT2B

4.02e-05312829787155
Pubmed

KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300.

REST EP300

4.02e-053128239430242
Pubmed

Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts.

PPP2CA PPP2CB

4.02e-05312827510677
Pubmed

The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence.

WNT5A DNMT1

4.02e-053128228100769
Pubmed

Lipoprotein receptors: signaling functions in the brain?

VLDLR RELN

4.02e-053128210380917
Pubmed

B56 regulatory subunit of protein phosphatase 2A mediates valproic acid-induced p300 degradation.

PPP2CA EP300

4.02e-053128215632055
Pubmed

C-Terminal Region Truncation of RELN Disrupts an Interaction with VLDLR, Causing Abnormal Development of the Cerebral Cortex and Hippocampus.

VLDLR RELN

4.02e-053128228123028
Pubmed

Abnormal positioning of granule cells alters afferent fiber distribution in the mouse fascia dentata: morphologic evidence from reeler, apolipoprotein E receptor 2-, and very low density lipoprotein receptor knockout mice.

VLDLR RELN

4.02e-053128211920707
Pubmed

Activation of Endogenous Retroviruses in Dnmt1(-/-) ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA.

SETDB1 DNMT1

4.02e-053128227151458
Pubmed

Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1.

VLDLR RELN

4.02e-053128212670700
Pubmed

Metabotropic glutamate receptor 5, and its trafficking molecules Norbin and Tamalin, are increased in the CA1 hippocampal region of subjects with schizophrenia.

GRM5 NCDN

4.02e-053128226048293
Pubmed

p21(WAF1) negatively regulates DNMT1 expression in mammalian cells.

EP300 DNMT1

4.02e-053128219275888
Pubmed

Prevalence of arrhythmia-associated gene mutations and risk of sudden cardiac death in the Finnish population.

RYR2 KCNH2

4.02e-053128223651034
Pubmed

SIK2 represses AKT/GSK3β/β-catenin signaling and suppresses gastric cancer by inhibiting autophagic degradation of protein phosphatases.

PPP2CA PHLPP2

4.02e-053128233128264
Pubmed

Functional importance of covalent homodimer of reelin protein linked via its central region.

VLDLR RELN

4.02e-053128221844191
Pubmed

mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch.

GRIN2A GRM5

4.02e-053128221521618
Pubmed

Reelin controls neuronal positioning by promoting cell-matrix adhesion via inside-out activation of integrin α5β1.

VLDLR RELN

4.02e-053128223083738
Pubmed

The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.

PPP2CA PPP2CB

4.02e-05312828206937
Pubmed

Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins.

EP300 DNMT1

4.02e-053128212071960
Pubmed

Homeostatic control of sensory output in basal vomeronasal neurons: activity-dependent expression of ether-à-go-go-related gene potassium channels.

PDE4A KCNH2

4.02e-053128219129398
Pubmed

Distinct phospholipase C-β isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostasis and wound closure.

PLCB1 PLCB2

4.02e-053128223478264
Pubmed

Thrombospondin 1 and Reelin act through Vldlr to regulate cardiac growth and repair.

VLDLR RELN

4.02e-053128238147128
Pubmed

Contributions of VLDLR and LRP8 in the establishment of retinogeniculate projections.

VLDLR RELN

4.02e-053128223758727
Pubmed

ApoER2 function in the establishment and maintenance of retinal synaptic connectivity.

VLDLR RELN

4.02e-053128221976526
Pubmed

Reelin and its receptors, VLDLR and ApoER2, in melanocytic nevi.

VLDLR RELN

4.02e-053128228255385
Pubmed

Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairing.

SETDB1 DNMT1

4.02e-053128233998651
Pubmed

Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2.

PPP2CA PPP2CB

4.02e-053128210441131
Pubmed

Protein phosphatase 2A dephosphorylates CaBP4 and regulates CaBP4 function.

PPP2CA PPP2CB

4.02e-053128223341017
Pubmed

Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively.

PPP2CA PPP2CB

4.02e-05312828383590
Pubmed

Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits.

PPP2CA PPP2CB

4.02e-053128215252037
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

INTS6L PCSK5 DDR1 ZCCHC9 UACA CARMIL1 ASH1L OBSCN NSD1 RPP14 OPRL1 FBN2 TSTD2 EP300 ACOXL

4.27e-0512151281515146197
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

VPS18 CARMIL1 CKAP5 GRIN2A PLD3 GRM5 CDC42BPB NCDN PPP2CB STXBP1 TTC7B SPON1 ATP1A1 PLCH1 DNAH6 VARS1

7.56e-0514311281637142655
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

L3MBTL2 DHX37 CARMIL1 SH3GL2 SHB CKAP5 NCDN FBN2 MAST4 KLHL7 CPNE3 ATP1A1

7.74e-058531281228718761
Pubmed

PP-1β and PP-2Aα modulate cAMP response element-binding protein (CREB) functions in aging control and stress response through de-regulation of αB-crystallin gene and p300-p53 signaling axis.

PPP2CA EP300

8.02e-054128234425033
Pubmed

Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity.

VLDLR RELN

8.02e-054128216481437
Pubmed

Disabled1 regulates the intracellular trafficking of reelin receptors.

VLDLR RELN

8.02e-054128215718228
Pubmed

Patterns of expression for the mRNA corresponding to the four isoforms of phospholipase Cbeta in mouse brain.

PLCB1 PLCB2

8.02e-05412829753089
Pubmed

The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development.

VLDLR RELN

8.02e-054128214724251
Pubmed

Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors.

VLDLR RELN

8.02e-054128217548821
Pubmed

Wnt5a-Ror2 signaling in mesenchymal stem cells promotes proliferation of gastric cancer cells by activating CXCL16-CXCR6 axis.

WNT5A CXCR6

8.02e-054128226708384
Pubmed

The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.

PPP2CA PPP2CB

8.02e-054128221454489
Pubmed

Specificity of cyclin E-Cdk2, TFIIB, and E1A interactions with a common domain of the p300 coactivator.

GTF2B EP300

8.02e-054128210330164
Pubmed

Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt.

CHUK PPP2CA

8.02e-054128216129692
Pubmed

Structural basis for specific recognition of reelin by its receptors.

VLDLR RELN

8.02e-054128220223215
Pubmed

Processing of Reelin by embryonic neurons is important for function in tissue but not in dissociated cultured neurons.

VLDLR RELN

8.02e-054128217442808
Pubmed

Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing.

MFNG NOTCH3

8.02e-054128211978185
Pubmed

Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse.

PPP2CA PPP2CB

8.02e-054128221998041
Pubmed

Reelin is a ligand for lipoprotein receptors.

VLDLR RELN

8.02e-054128210571240
Pubmed

Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation.

VLDLR RELN

8.02e-054128210571241
Pubmed

Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs.

PLCB1 PLCB2

8.02e-05412829188725
Pubmed

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

PPP2CA PPP2CB

8.02e-05412827616230
Pubmed

Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain.

PPP2CA PPP2CB

8.02e-05412829920888
Pubmed

Expression and regulation of reelin and its receptors in the enteric nervous system.

VLDLR RELN

8.02e-054128224844606
InteractionIGFL3 interactions

PCSK5 VLDLR FRAS1 WNT5A VWDE FBN2 NOTCH3

3.54e-07751227int:IGFL3
InteractionH2BC9 interactions

FRAS1 DNAH10 ASH1L CKAP5 NSD1 HKDC1 REST CDC42BPB PREX2 EGFL6 ZBTB11 DNAH6 DNMT1

3.16e-0644612213int:H2BC9
InteractionSHANK3 interactions

VPS18 SH3GL2 CKAP5 GRIN2A GRM5 CDC42BPB NCDN ARFGEF3 PPP2CA MEGF6 PLCB1 VARS1 NOTCH3

9.93e-0649612213int:SHANK3
InteractionNTN5 interactions

FRAS1 VWDE FBN2 NOTCH3

1.24e-05241224int:NTN5
Cytoband12q24.31

CABP1 DNAH10 DHX37 HCAR1

7.74e-0580128412q24.31
GeneFamilyPhospholipases

PLD3 PLCB1 PLCB2 PLCH1

6.87e-0542954467
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLCB1 PLCB2 PLCH1

1.28e-0419953832
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

ASH1L NSD1 SETDB1

7.47e-0434953487
GeneFamilyProtein phosphatase catalytic subunits|EF-hand domain containing

PPP2CA PPP2CB

2.05e-0313952693
CoexpressionMURARO_PANCREAS_BETA_CELL

VLDLR DDR1 SLC16A9 SPEG SH3GL2 PEG3 ASH1L LYST VWDE RRAGC PPP2CB STXBP1 MAST4 TTC7B KCNH2 PLCB1

1.41e-0594612716M39169
CoexpressionDESCARTES_FETAL_LIVER_MESOTHELIAL_CELLS

DDR1 CPAMD8 SPEG WNT2B GRIN2A RYR2 ARFGEF3 CRB2 ACOXL

2.27e-053131279M40228
CoexpressionGSE40493_BCL6_KO_VS_WT_TREG_DN

HKDC1 TSHB PRSS36 PREX2 KCNH2 SEZ6L

2.32e-051171276M9403
CoexpressionNABA_ECM_GLYCOPROTEINS

INTS6L LAMB4 FRAS1 RELN VWDE FBN2 SPON1

4.92e-051961277M3008
CoexpressionGSE10325_LUPUS_CD4_TCELL_VS_LUPUS_BCELL_UP

PCSK5 DHRS3 TXK MFNG MAST4 ATP1A1 DNMT1

5.42e-051991277M3084
CoexpressionGSE3691_IFN_PRODUCING_KILLER_DC_VS_CONVENTIONAL_DC_SPLEEN_DN

RNF144B PCSK5 GRIN2A RPP14 TTC7B MEGF6 ACOXL

5.59e-052001277M6366
CoexpressionGSE360_CTRL_VS_B_MALAYI_LOW_DOSE_MAC_UP

SHB PLD3 RYR2 CHUK MAST4 SEZ6L FCMR

5.59e-052001277M5168
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_MID_MESOTHELIAL_CELL

DDR1 IFT140 FRAS1 VPS18 DHRS3 SPEG PEG3 WNT2B RDH10 LYST ATP2C1 MEGF6 PLCB1 CRB2 PHLPP2

6.17e-0595512715M45680
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#2_top-relative-expression-ranked_200

ASH1L TIPARP MAST4 CPNE3

8.44e-06231224gudmap_developingGonad_e18.5_epididymis_200_k2
ToppCellCOPD-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

RNF144B PCSK5 CPAMD8 DHRS3 WNT2B LYST PREX2 TIPARP ATP1A1

4.57e-091911289ef16ad1c1cd2c0c0377957398c98775b62a81754
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CPAMD8 FRAS1 DHRS3 WNT5A HCAR1 ARFGEF3 MAST4 NOTCH3 ACOXL

6.26e-091981289af399569c718f5fd971d73a7926768c9311002a3
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CPAMD8 FRAS1 DHRS3 WNT5A HCAR1 ARFGEF3 MAST4 NOTCH3 ACOXL

6.26e-0919812891408e02e053ad3406229bfe8189da03be6366e81
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 RELN DNAH10 OBSCN RYR2 ARFGEF3 FBN2 PLCH1

6.32e-0818412882cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 RELN DNAH10 OBSCN RYR2 ARFGEF3 FBN2 PLCH1

6.32e-081841288ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRAS1 RELN DNAH10 OBSCN RYR2 ARFGEF3 FBN2 PLCH1

6.32e-0818412882b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CABP1 SH3GL2 PEG3 GRIN2A GRM5 RYR2 STXBP1 PLCB1

1.11e-0719812888ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

RNF144B PCSK5 CPAMD8 RASGRF2 PREX2 MAST4 PLCB1

8.84e-0717912872a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCelldroplet-Fat-Scat-18m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DHRS3 DHX37 PREX2 RYR2 MFNG UNC45B SLC7A10

9.88e-071821287fea094fe0e7796c084e60b5310c1559658633f7a
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

UACA OBSCN PREX2 RYR2 EGFL6 PLCB1 NOTCH3

1.14e-061861287888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RNF144B PCSK5 RELN RASGRF2 TFF2 FBN2 PLCH1

1.14e-06186128796f6603cc75fa1ffc2a2fdb94ec0ec09498e540a
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

INTS6L PCSK5 WNT5A SPEG KCNH2 SPON1 PLCB1

1.18e-061871287387cb27c8a20031cd87381a9e1172f1f62e1488b
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

RNF144B PCSK5 CPAMD8 RASGRF2 PREX2 MAST4 PLCB1

1.18e-06187128740ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

UACA OBSCN PREX2 RYR2 EGFL6 PLCB1 NOTCH3

1.32e-0619012874eb92aef1ee868f4537483d19014d947b7684612
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

UACA OBSCN PREX2 RYR2 EGFL6 PLCB1 NOTCH3

1.32e-0619012877be4341e2909101d756f14031c21e705eb45e69a
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

HKDC1 F11 ARFGEF3 MAST4 MEGF6 PLCH1 ACOXL

1.41e-061921287cc9911e182a289779a2612bc213daae5607689e7
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

VLDLR F11 ARFGEF3 FCGBP MAST4 PLCB1 ATP1A1

1.41e-061921287ee27d27e3d269764dbe8711d0b37ff9331a298a9
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CABP1 SPEG ADAMTS12 MEGF6 SPON1 NOTCH3 SEZ6L

1.46e-061931287469a7f1c2ff7137cc5a064464456911f67f92e70
ToppCellRV-09._Endothelium_I|RV / Chamber and Cluster_Paper

RNF144B CABP1 CPAMD8 RASGRF2 WNT2B PREX2 PLCB1

1.51e-0619412877b408096e717f2327c12aea35a8d5fc4621d3b06
ToppCellnucseq-Mesenchymal-Myocytic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

UACA OBSCN RYR2 EGFL6 ADAMTS12 PLCB1 NOTCH3

1.51e-0619412872d66091097e106c7bee22e5281f50724700bdf8d
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CPAMD8 FRAS1 DHRS3 WNT5A ARFGEF3 MAST4 ACOXL

1.57e-061951287dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CABP1 CARMIL1 SH3GL2 GRIN2A RYR2 STXBP1 PLCB1

1.57e-0619512872e1df01bf6e4e98e6cd9fb50926e34c5077b8666
ToppCelldroplet-Bladder-nan-24m-Endothelial|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CABP1 RELN RASGRF2 SPEG MFNG UNC45B NOTCH3

1.62e-0619612879a90dd26e7a43e3fd55e7c5d8354cfa4cdd5a6cc
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CABP1 SH3GL2 GRIN2A GRM5 RYR2 STXBP1 PLCB1

1.62e-061961287676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCelldroplet-Bladder-nan-24m-Endothelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CABP1 RELN RASGRF2 SPEG MFNG UNC45B NOTCH3

1.62e-06196128704dfef1bd4ebb0e9469ae80024dc177e469a2560
ToppCellParenchymal-NucSeq-Stromal-Pericyte-Muscle_pericyte_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

OBSCN PREX2 RYR2 EGFL6 TTC7B PLCB1 NOTCH3

1.68e-061971287f66945f9007d59d4208849c7fd727f8519713fbc
ToppCelldroplet-Bladder-nan-24m-Endothelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CABP1 RELN RASGRF2 SPEG MFNG UNC45B NOTCH3

1.68e-061971287488e85991c5e668afb7672942726d9295b8fc7d8
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3GL2 PEG3 GRIN2A GRM5 RYR2 STXBP1 PLCB1

1.73e-0619812876d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3GL2 PEG3 GRIN2A GRM5 RYR2 STXBP1 PLCB1

1.73e-0619812874ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellBronchial-10x5prime-Stromal-Pericyte-Muscle_pericyte_pulmonary|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PEG3 OBSCN PREX2 RYR2 EGFL6 PLCB1 NOTCH3

1.85e-06200128712326cc6f0af24bacba9493dc79e7c7347db2f41
ToppCellBronchial-10x5prime-Stromal-Pericyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PEG3 OBSCN PREX2 RYR2 EGFL6 PLCB1 NOTCH3

1.85e-062001287362706445edb33b313684efe50b1f44f5f816e67
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

RELN GRIN2A GRM5 RYR2 FBN2 SEZ6L

4.12e-061461286c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RNF144B CPAMD8 SPEG WNT2B PREX2 PLCB1

9.54e-061691286c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCellfacs-Marrow-T-cells-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDR1 CARMIL1 HCAR1 ITGAD SLC37A2 TSSK3

1.02e-0517112866a0fafb8fd9fc7671618eeb2bf528ce8ce86b794
ToppCellControl-Fibroblasts-Pericytes|Control / group, cell type (main and fine annotations)

OBSCN PREX2 RYR2 EGFL6 PLCB1 NOTCH3

1.02e-051711286080003f698f867935c2bfc55d241d3650f45a0ab
ToppCellfacs-Marrow-T-cells-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDR1 CARMIL1 HCAR1 ITGAD SLC37A2 TSSK3

1.02e-051711286e02b5831768dbb1b68998b672e55c9680ab0cc86
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

SPEG RYR2 EGFL6 KCNH2 PLCB1 NOTCH3

1.05e-051721286c62cad0f4212d1e9ea1ec3143ad3c4e06aff0ebf
ToppCellAdult-Mesenchymal-pericyte_cell-D231|Adult / Lineage, Cell type, age group and donor

SPEG BEND2 RYR2 EGFL6 PLCB1 NOTCH3

1.05e-051721286858cee96c1c06160863b4adcd7023c0d678bd50f
ToppCellAdult-Epithelial-lung_goblet_cell-D231|Adult / Lineage, Cell type, age group and donor

FRAS1 SLC16A9 WNT5A ARFGEF3 FCGBP NOTCH3

1.13e-0517412867d2f802f493f19a068e097b2909a9000e2160266
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC16A9 DHX37 ARFGEF3 FCGBP PLCH1 EP300

1.16e-051751286dbd9dac129fb6ae5f55e7b96d04b37585458dc4a
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VLDLR PEG3 CKAP5 NSD1 LYST RYR2

1.20e-051761286749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-Pericytes|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

CABP1 UACA BEND2 EGFL6 ADAMTS12 NOTCH3

1.20e-0517612862015539c58aa0bb118e111ffedd63dd9fe863bb1
ToppCellAdult-Epithelial-club_cell-D122|Adult / Lineage, Cell type, age group and donor

CPAMD8 FRAS1 WNT5A HCAR1 ARFGEF3 MAST4

1.28e-05178128635a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 F11 ARFGEF3 MAST4 PLCB1 ATP1A1

1.37e-051801286eee71184ebed2694d3e60f579a44b3cf7dd2cd35
ToppCelldroplet-Limb_Muscle-Pre-Sort|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CABP1 SPEG SHB RYR2 KCNH2 NOTCH3

1.37e-051801286af2bafcd1b2082629de3ea336711add01565c4c4
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 F11 ARFGEF3 MAST4 PLCB1 ATP1A1

1.37e-051801286a17dbe03597b81e7a1fe2bf2d23e59e55c615a2a
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CABP1 SPEG SHB RYR2 KCNH2 NOTCH3

1.37e-051801286f29a995cf6e1a1836ed68b73258d9370bf3d4434
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

FRAS1 UACA PREX2 RYR2 ADAMTS12 SPON1

1.41e-0518112869ede19228ba5c0668a9c06c915510b95585216ef
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

CPAMD8 ARFGEF3 STXBP1 MAST4 ATP1A1 ACOXL

1.41e-051811286c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l19|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

UACA RASGRF2 PREX2 MFNG MAST4 UNC45B

1.45e-051821286840427d1c23d60482c943ff006b14007ed44d247
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CABP1 F11 ARFGEF3 MAST4 PLCB1 ATP1A1

1.45e-051821286041bc819e6cf2618bf86bce8dfe2df673f392ba3
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CABP1 GRIN2A ADAMTS12 MEGF6 SPON1 NOTCH3

1.50e-051831286b4f29dd3994009bb5eb769d36d95886664e7f87d
ToppCellCOVID-19-Fibroblasts-Pericytes|COVID-19 / group, cell type (main and fine annotations)

UACA PREX2 RYR2 EGFL6 PLCB1 NOTCH3

1.59e-0518512864905adaeeffd353e089578e5ea614437dbe794e6
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam____podocyte-3|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH10 HCAR1 TFF2 FCGBP MEGF6 DNAH6

1.64e-05186128629c79b5a29907d4f3f87ad2ca04840c0f15b7d4e
ToppCellAdult-Epithelial-club_cell-D231|Adult / Lineage, Cell type, age group and donor

CPAMD8 FRAS1 HCAR1 ARFGEF3 MAST4 NOTCH3

1.69e-051871286ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

F11 ARFGEF3 MAST4 PLCB1 ATP1A1 NNT

1.69e-05187128652b5b38bef3cc06487cf42c6fb22fb33f0c7ce2b
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RNF144B PCSK5 RELN RASGRF2 FBN2 PLCH1

1.69e-05187128685f1678338a47d91e296f0620d4887f057eb7e70
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

OBSCN PREX2 RYR2 EGFL6 PLCB1 NOTCH3

1.69e-051871286a2bf958ea59c359a265bfa437d59315e1920cdd4
ToppCellCOVID-19-lung-Artery_EC|lung / Disease (COVID-19 only), tissue and cell type

CPAMD8 RASGRF2 WNT2B PREX2 MAST4 PLCB1

1.75e-051881286eecd7482b3c97d7f49993cb17edfab30c61232fc
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IP6K3 WNT5A OBSCN GRIN2A PREX2 FBN2

1.75e-051881286997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

HKDC1 AHCYL2 ARFGEF3 MAST4 PLCH1 ACOXL

1.75e-051881286ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D231|Adult / Lineage, Cell type, age group and donor

ARFGEF3 STXBP1 MAST4 MEGF6 PLCH1 ACOXL

1.80e-051891286dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CABP1 SPEG CARMIL1 RYR2 EGFL6 NOTCH3

1.80e-051891286975e7aa3b862a8b07c2ab8426a14f5cc54998aca
ToppCellEndothelial-endothelial_cell_of_artery|World / Lineage, Cell type, age group and donor

RNF144B CPAMD8 RASGRF2 WNT2B PREX2 PLCB1

1.80e-051891286fdd89c71113ac99b7c800c6def8888e512ff1128
ToppCellMesenchymal-pericyte_cell|World / Lineage, Cell type, age group and donor

OBSCN PREX2 RYR2 EGFL6 PLCB1 NOTCH3

1.80e-051891286d7ed96add29f219183c802895fbff519b627f635
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

INTS6L PCSK5 WNT5A SPEG TXK PLCB1

1.80e-0518912860abc7a4900cc9033bc1be69b770ccc54a6bf41b4
ToppCellAdult-Epithelial-club_cell|Adult / Lineage, Cell type, age group and donor

CPAMD8 FRAS1 WNT5A ARFGEF3 MAST4 NOTCH3

1.85e-051901286756bff697d30aec56c0ebfca94295f084a15bf37
ToppCellCOVID-19-Heart-EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

RNF144B CPAMD8 RASGRF2 PREX2 ADAMTS12 NOTCH3

1.85e-051901286a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CABP1 ADAMTS12 MEGF6 SPON1 PLXNA1 NOTCH3

1.85e-051901286140aca04c044cd7a93f81ff1631b00b5216d2cb1
ToppCellChildren_(3_yrs)-Epithelial-club_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CPAMD8 FRAS1 WNT5A ARFGEF3 MAST4 ACOXL

1.91e-05191128623776c7302cead3881b39127398f3b3e0d27885e
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

OBSCN PREX2 RYR2 EGFL6 PLCB1 NOTCH3

1.91e-0519112861626b23a57429f835fddc052e3c57f63a4e5b8bb
ToppCellMesenchymal-vascular_smooth_muscle_cell|World / Lineage, Cell type, age group and donor

CABP1 SPEG RYR2 EGFL6 PLCB1 NOTCH3

1.91e-051911286fd89fbc62aa1c73e0f659991e3bd726a0c97bd68
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

OBSCN PREX2 RYR2 EGFL6 PLCB1 NOTCH3

1.91e-051911286716dfa7fccbd62b5f574792e68a26dc6c45511dc
ToppCellRA-09._Endothelium_I|World / Chamber and Cluster_Paper

RNF144B CPAMD8 RASGRF2 WNT2B PREX2 PLCB1

1.91e-051911286c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 CABP1 IP6K3 RASGRF2 PREX2 MEGF6

1.91e-051911286b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 SPEG RYR2 EGFL6 PLCB1 NOTCH3

1.97e-051921286992d08092edbc68c47b945deb8708379738c239a
ToppCellControl-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

RNF144B PCSK5 CPAMD8 PREX2 MAST4 ATP1A1

1.97e-0519212867e89b9125e8b85f6be85eeccef5c8644647ab0e1
ToppCellIPF-Stromal-SMC|Stromal / Disease state, Lineage and Cell class

CABP1 SPEG EGFL6 PLCB1 NOTCH3 FCMR

1.97e-0519212869b06c7336624ef21f8e5393725b56038a8028e57
ToppCellRV-09._Endothelium_I|World / Chamber and Cluster_Paper

RNF144B CABP1 CPAMD8 RASGRF2 PREX2 PLCB1

2.03e-051931286e3fa47e2c7cd8a5b69186711c57751f2296de8ae
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 UACA PEG3 PREX2 UNC45B PLCB1

2.09e-05194128644c7d4b75f3b7c9301eba20610e548a01a84ae40
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 UACA PEG3 PREX2 UNC45B PLCB1

2.09e-0519412867f24023df47935286f185dd428d48797daf26f49
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DDR1 SLC16A9 HCAR1 RDH10 FCGBP ATP1A1

2.15e-0519512862a9a36df1dbc4eac77a8ddbe939ec8a8d6c41464
ToppCellLA-09._Endothelium_I|World / Chamber and Cluster_Paper

RNF144B CPAMD8 RASGRF2 WNT2B PREX2 PLCB1

2.15e-051951286fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DDR1 SLC16A9 HCAR1 RDH10 FCGBP ATP1A1

2.15e-051951286576142b4e75457c0973051bccc4163bd624496af
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CABP1 SPEG ADAMTS12 SPON1 PLXNA1 NOTCH3

2.15e-051951286c51b1bee79e77aa2ac444a4883ef533c0095eaad
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DDR1 SLC16A9 HCAR1 RDH10 FCGBP ATP1A1

2.15e-0519512868f151066ad3ebd9661ea0b733f03c2ce1518f9ad
ToppCellLV-09._Endothelium_I|World / Chamber and Cluster_Paper

RNF144B CABP1 CPAMD8 RASGRF2 PREX2 PLCB1

2.15e-05195128619e0a6c3eae1615aaa39767300acd937dfcb2a7f
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CABP1 SPEG ADAMTS12 SPON1 PLXNA1 NOTCH3

2.15e-05195128643d372373367b71243c6ea958aedccde4478618f
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN PEG3 ASH1L NSD1 STXBP1 SEZ6L

2.15e-0519512863e519cffa6144a62b06124642a14c9ff39b76554
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CABP1 SH3GL2 GRIN2A STXBP1 MAST4 PLCB1

2.15e-051951286787e95fb59c40bba784544b662fac37606ae1427
ToppCellASK440-Epithelial-Type_2|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

AHCYL2 F11 ARFGEF3 STXBP1 ATP1A1 ACOXL

2.21e-051961286754b4202b617165c6994a0b5a9b1e486dccdd44d
ToppCellParenchymal-NucSeq-Stromal-Pericyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

OBSCN PREX2 RYR2 EGFL6 PLCB1 NOTCH3

2.27e-05197128641dd312f46a2b983c8d864adeb6970c0ca4a8048
ToppCellLV-09._Endothelium_I|LV / Chamber and Cluster_Paper

RNF144B CABP1 CPAMD8 RASGRF2 PREX2 PLCB1

2.27e-051971286f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SH3GL2 GRIN2A GRM5 RYR2 STXBP1 PLCB1

2.34e-051981286c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellmoderate-Epithelial-Secretory|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DDR1 SLC16A9 DHRS3 CARMIL1 RDH10 ARFGEF3

2.34e-0519812867d96d7105a849c7280ce87bd76ce130ac47384fd
ToppCelldistal-Epithelial-Alveolar_Epithelial_Type_2-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DDR1 RDH10 HKDC1 AHCYL2 F11 ARFGEF3

2.34e-051981286de5748c2b66ecc432974cf095ecd241369579f7c
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PEG3 GRIN2A GRM5 RYR2 STXBP1 PLCB1

2.34e-0519812860ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CPAMD8 UACA RASGRF2 WNT2B PREX2 PLCB1

2.34e-051981286002424b24dacac553e02d0f764a6e8a1e567b9df
ToppCellBronchial-NucSeq-Stromal-Pericyte-Muscle_pericyte_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

OBSCN PREX2 RYR2 EGFL6 PLCB1 NOTCH3

2.41e-051991286929f809579368201331d9099d8904b6e3c41797b
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

RNF144B DDR1 FCGBP SPON1 PLCB1 ATP1A1

2.41e-0519912862e7f517c0444b4f29ff11c26ab32e9cc0f7e99ef
DrugDiethylstilbestrol

VLDLR DDR1 RELN DHRS3 WNT5A WNT2B TSHB AHCYL2 PLD3 TIPARP TFF2 CHUK FBN2 FCGBP CXCR6 KCNH2 SPON1 PLCB1 NNT SLC7A10 VARS1 EP300 DNMT1

7.13e-07130512623ctd:D004054
Diseaseidiopathic pulmonary fibrosis (implicated_via_orthology)

DDR1 EP300

1.72e-0521232DOID:0050156 (implicated_via_orthology)
Diseasealcohol use disorder (implicated_via_orthology)

KDM5A RYR2 OPRL1 STXBP1 ATP1A1 EP300 NOTCH3

1.84e-051951237DOID:1574 (implicated_via_orthology)
DiseaseSchizophrenia

VLDLR DDR1 RELN PDE4A GRIN2A REST GRM5 ADAMTS12 SETDB1 STXBP1 KCNH2 PLCB1 SLC7A10 DNMT1

1.96e-0588312314C0036341
DiseaseBipolar Disorder

RELN PDE4A TSHB GRIN2A GRM5 GSTZ1 PLCB1 ATP1A1 SEZ6L DNMT1

3.27e-0547712310C0005586
Diseaseschizophrenia (is_marker_for)

CABP1 RELN SETDB1 DNMT1

3.43e-05441234DOID:5419 (is_marker_for)
DiseaseColorectal Carcinoma

ZDHHC2 CPAMD8 VPS18 RASGRF2 PEG3 OBSCN GRIN2A PREX2 NCDN GTF2B FBN2 EP300

3.88e-0570212312C0009402
Diseaseprostate cancer (is_marker_for)

KDM5A TFF2 PPP2CA SETDB1 EP300 DNMT1

5.06e-051561236DOID:10283 (is_marker_for)
Diseaselymphocyte count

FRAS1 PDE4A RAPSN DNAH10 NSD1 HKDC1 REST PLD3 LYST PREX2 OPRL1 GTF2B PLCB1 SLC7A10 VARS1 ACOXL DNMT1

1.24e-04146412317EFO_0004587
DiseaseWest Syndrome

WDR45 STXBP1 PLCB1

1.34e-04241233C0037769
DiseaseICAM-1 measurement

PDE4A GTF2B DNMT1

1.34e-04241233EFO_0004520
Diseaseneutrophil count

VLDLR CPAMD8 RAPSN ASH1L NSD1 TSHB REST PREX2 EGFL6 RRAGC DCUN1D2 PLCB1 PLCB2 ATP1A1 ACOXL DNMT1

2.06e-04138212316EFO_0004833
DiseaseVestibular Diseases

GSTZ1 ATP1A1

3.57e-0471232C0042594
DiseaseMorphine Abuse

GRIN2A OPRL1

3.57e-0471232C0600272
DiseaseMorphine Dependence

GRIN2A OPRL1

3.57e-0471232C0026552
Diseaseretinal detachment, retinal break

CPAMD8 FRAS1 GRM5

4.20e-04351233EFO_0005773, EFO_0010698
DiseaseHbA1c measurement

CPAMD8 B3GLCT RAPSN CARMIL1 ASH1L HKDC1 ITGAD OPRL1 OR52N2 PLCB1

5.43e-0467512310EFO_0004541
Diseasemyeloid white cell count

VLDLR RAPSN DNAH10 HKDC1 REST PREX2 RRAGC PLCB1 PLCB2 ATP1A1 ACOXL DNMT1

5.59e-0493712312EFO_0007988
DiseaseNeurodevelopmental Disorders

ASH1L CDC42BPB WDR45 STXBP1

6.30e-04931234C1535926
Diseaseplatelet crit

VLDLR PDE4A RAPSN IP6K3 CARMIL1 REST RPP14 ITGAD MAST4 PLCB1 SLC7A10 NOTCH3

6.43e-0495212312EFO_0007985
Diseasecardiovascular disease

B3GLCT WNT2B PRSS36 OPRL1 GTF2B FBN2 PLCB1 DNMT1

6.79e-044571238EFO_0000319
Diseasealopecia areata (is_marker_for)

KDM5A DNMT1

7.59e-04101232DOID:986 (is_marker_for)
Diseaseage at onset, multiple sclerosis

PCSK5 RELN

7.59e-04101232EFO_0004847, MONDO_0005301
DiseaseHIV-1 infection

DDR1 GRIN2A GRM5 HMGXB3

7.68e-04981234EFO_0000180
Diseaseresponse to statin, myopathy

RASGRF2 FBN2

9.25e-04111232EFO_0004145, GO_0036273
DiseaseLong QT Syndrome

RYR2 KCNH2

9.25e-04111232C0023976
Diseasecryptic phenotype measurement

WNT2B KCNH2 PLCB1

1.00e-03471233EFO_0021487
DiseaseIGF-1 measurement

IFT140 PDE4A RAPSN CARMIL1 GRM5 PRSS36 ACOXL DNMT1

1.04e-034881238EFO_0004627
Diseasearachidonoylcarnitine (C20:4) measurement

RAPSN SLC16A9

1.11e-03121232EFO_0800544
Diseaseautistic disorder (is_marker_for)

VLDLR RELN

1.11e-03121232DOID:12849 (is_marker_for)
Diseaseresponse to fenofibrate

PCSK5 AHCYL2 SPON1

1.20e-03501233GO_1901557
Diseasedihomo-linolenoylcarnitine (C20:3n3 or 6) measurement

RAPSN SLC16A9

1.30e-03131232EFO_0800547
Diseasevascular brain injury measurement, vascular brain injury

PCSK5 SEZ6L

1.30e-03131232EFO_0006791, EFO_0006800
Diseaselow density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

RAPSN DNAH10 CARMIL1 DEFB134 OPRL1

1.54e-032001235EFO_0004611, EFO_0020945
Diseasedelta-6 desaturase measurement

RAPSN MAST4

1.75e-03151232EFO_0007765
DiseaseFEV/FEC ratio

PCSK5 FRAS1 IP6K3 ZNRD2 SPEG SHB NSD1 REST FCGBP TTC7B MEGF6 KLHL7 CRB2

1.87e-03122812313EFO_0004713
DiseaseDementia

NOTCH3 DNMT1

2.25e-03171232C0497327
DiseaseC-X-C motif chemokine 16 measurement

CXCR6 ACOXL

2.52e-03181232EFO_0010911
Diseasesyndrome (implicated_via_orthology)

ZDHHC2 NSD1

2.52e-03181232DOID:225 (implicated_via_orthology)
Diseaseschizophrenia (implicated_via_orthology)

RELN GRM5 PLCB1

2.91e-03681233DOID:5419 (implicated_via_orthology)
Diseasebipolar I disorder

B3GLCT RAPSN GRIN2A PRSS36

2.92e-031411234EFO_0009963
Diseaseapolipoprotein A 1 measurement

RAPSN IP6K3 DNAH10 HCAR1 NSD1 GRM5 SPON1 NNT SLC7A10 ACOXL

2.96e-0384812310EFO_0004614
Diseasenon-high density lipoprotein cholesterol measurement

PCSK5 VLDLR PDE4A RAPSN DNAH10 CARMIL1 NSD1 OPRL1 SLC7A10

3.05e-037131239EFO_0005689
Diseasevisceral:subcutaneous adipose tissue ratio

VPS18 DNAH10 SLC7A10

3.16e-03701233EFO_0004767
DiseaseManic Disorder

RELN TSHB GRIN2A

3.29e-03711233C0024713
Diseasevenous thromboembolism, plasminogen activator inhibitor 1 measurement

CKAP5 F11

3.44e-03211232EFO_0004286, EFO_0004792
DiseaseHbA1c measurement, response to sulfonylurea

SLC16A9 GRIN2A

3.44e-03211232EFO_0004541, EFO_0007922
Diseasemonocyte count

VLDLR CARMIL1 ASH1L REST LYST PREX2 EGFL6 PLCB1 ATP1A1 SLC7A10 VARS1 ACOXL DNMT1

3.48e-03132012313EFO_0005091
Diseasecholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement

RAPSN DNAH10 CARMIL1 HCAR1 OPRL1

3.57e-032431235EFO_0004612, EFO_0020944
Diseasetriacylglycerol 54:8 measurement

PLCB1 FCMR

4.12e-03231232EFO_0010426
Diseaseidiopathic pulmonary fibrosis (is_marker_for)

DDR1 EP300

4.12e-03231232DOID:0050156 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
VMQSLGYCCGRKLEF

EP300

1156

Q09472
IRCICGLYKDEGLMI

ASH1L

2586

Q9NR48
ISGRYDCIDINECTM

EGFL6

211

Q8IUX8
CRCYSNDAPDDMVLG

B3GLCT

411

Q6Y288
CMYLVVFVCGLVGNS

CXCR6

36

O00574
CLVRMGYQCTFGVLQ

DNMT1

1286

P26358
CCGATAVIMLVGDTY

SLC7A10

371

Q9NS82
FLPGVCMYVCVDREA

GJA10

506

Q969M2
DRVMSVCLRVELYGC

DDR1

171

Q08345
VECTFLDYIMGGCQL

CPNE3

276

O75131
KDGYINCRDLGNCMR

CABP1

241

Q9NZU7
IGLCSNRMFCYAVLG

ATP2C1

836

P98194
GICKMVGCDYEIDSN

ADAMTS12

671

P58397
RCLQDCRECTGGMGY

ACOXL

341

Q9NUZ1
VLGATMESRCYGCAV

ZFYVE19

71

Q96K21
GIDSECINRMLLYEC

NSD1

1906

Q96L73
YRLLGRLGSAMECCE

RAPSN

216

Q13702
ITQMCEVTGGRSYCV

INTS6L

196

Q5JSJ4
EICMDFLQGTCIYGR

TIPARP

241

Q7Z3E1
LCLCNGLSYEMVGQE

LRRC9

16

Q6ZRR7
CLKQYMQLAIREGCG

RNF144B

56

Q7Z419
ALQRMLVEFYGLDGC

SLC16A9

156

Q7RTY1
SCCDYLVGEERQMAE

REST

61

Q13127
GVVMYNCSCLARDLT

PLD3

231

Q8IV08
TDCLQCMDGYVLQDG

FRAS1

971

Q86XX4
CMDGYVLQDGACVEQ

FRAS1

976

Q86XX4
ARVVACFCEGMTVRG

GRM5

271

P41594
ACYALMELGIQECTR

NCDN

336

Q9UBB6
CKVLLDGYLMICVDG

L3MBTL2

451

Q969R5
LGYAGVTCEMEVDEC

CRB2

136

Q5IJ48
CVLDGVRGCDSYMVY

CHUK

371

O15111
ELCCGSVKEMRERYA

ATP1A1

461

P05023
DGFCELCGYSRAEVM

KCNH2

46

Q12809
ISGINSMIYCLCSEG

BEND2

566

Q8NDZ0
MACTQAGERTAIYCL

DCUN1D2

16

Q6PH85
FECLTVRDYNDMICG

HMGXB3

871

Q12766
VRDYNDMICGICGVA

HMGXB3

876

Q12766
INCTEGYFMEDGRCV

PCSK5

801

Q92824
GYFMEDGRCVQSCSI

PCSK5

806

Q92824
ENGCLVYNDTTMVCR

PLXNA1

1091

Q9UIW2
CVSDYAGGRSLTCIM

PDE4A

381

P27815
ICMAGFTGTYCEVDI

NOTCH3

456

Q9UM47
EAELMGRCYLHQCTG

LMLN2

546

A0A1B0GTW7
CSHGMVEANGLIYVC

KLHL7

421

Q8IXQ5
MVGLIRQGYACEVCS

CDC42BPB

1046

Q9Y5S2
LGGTECFLYRVMSCD

OR10G8

106

Q8NGN5
YGCMTQIIVFLLVGC

OR2D3

111

Q8NGH3
MYIIAVVGNCGLICL

OR52N2

36

Q8NGI0
CYRCGNQAAIMELDD

PPP2CB

266

P62714
CYRCGNQAAIMELDD

PPP2CA

266

P67775
CLGVRICGMQVYQTD

IP6K3

246

Q96PC2
VDLYVCMFCGRGNNE

KDM5A

291

P29375
TFRPRGMLYECQECG

PEG3

961

Q9GZU2
AIDNVYIGDGCIDMC

RELN

2471

P78509
QLGGAECCLLAAMAY

OR2T10

106

Q8NGZ9
TGRLYDCAAATGMCQ

ITGAD

61

Q13349
QICGLAMADAGEYLC

OBSCN

3506

Q5VST9
AMADAGEYLCVCGQE

OBSCN

3511

Q5VST9
RGLAMADTGEYSCVC

OBSCN

3596

Q5VST9
LVAEDAGEYLCMCGK

OBSCN

3686

Q5VST9
AGEYLCMCGKERTSA

OBSCN

3691

Q5VST9
MLCAGYPEGRRDTCQ

PRSS36

226

Q5K4E3
CVLYAEGQENRCEMT

PRSS36

751

Q5K4E3
GICRLECYESEMLVA

DEFB134

36

Q4QY38
DYTNGRATTCCVMLI

SLC37A2

356

Q8TED4
EELGCLVESYGMNVC

CKAP5

1346

Q14008
TDRCYLCLMGALQLD

DNAH6

1451

Q9C0G6
MGTCVYVLAQTCGTR

FCGBP

1271

Q9Y6R7
DFMGTCVYVLAQTCG

FCGBP

3671

Q9Y6R7
MTEACIKGGIEACYA

ARFGEF3

411

Q5TH69
AKGDGCCLMQIDVTY

CPAMD8

1481

Q8IZJ3
ISGYTLRLCKMDNEC

F11

366

P03951
LEGCCGEDIIYMNEN

LYST

1881

Q99698
GIYCVGDEVTMADLC

GSTZ1

151

O43708
RHLCMVMEYVEGGDC

MAST4

641

O15021
MYNGSCCRIEGDTIS

HCAR1

1

Q9BXC0
LYEMIVRGSCFCNGH

LAMB4

256

A4D0S4
MVCGALLRGCLQYLA

CARMIL1

381

Q5VZK9
VTSFCLGMGARRVCY

ENGASE

401

Q8NFI3
TGRVCLDIRMEQCYL

FBN2

991

P35556
LNVPGAYRCECEMGF

FBN2

1466

P35556
MVLLGAVGACEYASC

DHX37

856

Q8IY37
LLCVVTNCGEGMDYR

DNAH10

1851

Q8IVF4
VRYLAGCGLQSCQML

RYR2

2266

Q92736
LLEQIADCCMRQGSY

IFT140

1191

Q96RY7
GYIGCRELGACMRTL

CABP2

96

Q9NPB3
MGTECHYFICDVGNR

DHRS3

86

O75911
DDCTMGYIIECKLGG

MFNG

231

O00587
GLGCTECVLLAVMAY

OR6A2

111

O95222
VCVGGLLGNCLVMYV

OPRL1

61

P41146
GVLVAMALDCYVAIC

OR52L1

131

Q8NGH7
GRQCYRIEMEIVNSC

MEGF6

321

O75095
QIMYLGSGLCCVGAL

NNT

621

Q13423
ECGTDALRFGLCAYM

VARS1

916

P26640
CTKLCGGGIQERYMT

SPON1

766

Q9HCB6
CDMIDVVIDVSCIYG

RRAGC

286

Q9HB90
CYEGFELMGEVTIRC

SEZ6L

901

Q9BYH1
GCCAALKAMGSIVYV

AHCYL2

406

Q96HN2
LRAMCRLDYCGGSGE

SHB

106

Q15464
CEIGLIAGTGSNMCY

HKDC1

671

Q2TB90
RPAGMYLLEGCSCER

RASGRF2

61

O14827
CRVGLGICYDMRFAE

NIT2

146

Q9NQR4
FCCAMETGVRIYNVE

WDR45

21

Q9Y484
CIILVGMSYLGGCVN

OR5P3

141

Q8WZ94
ILGGVSLNEMRCAYE

STXBP1

541

P61764
VCPYLVDTGMFRGCR

RDH10

241

Q8IZV5
CGLCLRTMQEIERYL

SETDB1

631

Q15047
VQTARECLIKCMDYG

UNC45B

911

Q8IWX7
GCMGYCAEAISDARL

VWDE

151

Q8N2E2
CGECGMVFQRRYALI

ZBTB11

571

O95625
ECAECGQAFVMGSYL

ZNF497

331

Q6ZNH5
VYLNIGEEGCTCEMN

PHLPP2

1031

Q6ZVD8
RRCGAQDAGVYSCMA

SPEG

96

Q15772
AAMLDCGRDCYAIRV

SLC26A1

166

Q9H2B4
DYRAGDMICPECGLV

GTF2B

26

Q00403
SGVQMDQPCCRALYD

SH3GL2

286

Q99962
RQMVEAIRYCHGCGV

TSSK3

116

Q96PN8
AAECVYCGELMIRSI

VPS18

941

Q9P253
GDLIRERSYMCSECG

ZNF256

231

Q9Y2P7
CVMEVSDRRNCGYPG

TFF2

81

Q03403
IYLCREMAGSGTCGT

FCMR

46

O60667
CRTREEAMIFGVGLC

PREX2

526

Q70Z35
VLMYCTGGIRCERGS

TSTD2

351

Q5T7W7
ELMCCGRGYDQFKTV

WNT5A

336

P41221
VEMYRQVLLSGCRCV

PLCB1

346

Q9NQ66
SAEMYRQVLLSGCRC

PLCB2

341

Q00722
MYARVLQEGCRCVEV

PLCH1

331

Q4KWH8
ICAGYCMTRDINGKL

TSHB

46

P01222
YRMLGETCADCGTIL

ZNRD2

46

O60232
RTALMLGCEYGCRDA

UACA

201

Q9BZF9
CQDICEGMEYLERNG

TXK

371

P42681
IALGRRGQYEMLSEC

TTC7B

371

Q86TV6
EMVLLDGGCESSCYV

XPNPEP3

326

Q9NQH7
ALENQDMGTGICYRC

ZCCHC9

146

Q8N567
TMSGAIRYCDRCQLI

ZDHHC2

121

Q9UIJ5
YMKVCLEFQDCGVGL

RPP14

21

O95059
EIMCCGRGYDTTRVT

WNT2B

336

Q93097
CSRGYQMDLATGVCK

VLDLR

421

P98155
CDACLRMGNLYDIDE

GRIN2A

1236

Q12879