Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DYNC2H1 DNAH17 DNAH1	1.94e-05	18	59	3	GO:0008569
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DYNC2H1 DNAH17 DNAH1	7.62e-05	28	59	3	GO:0051959
GeneOntologyMolecularFunction	dynein intermediate chain binding	DYNC2H1 DNAH17 DNAH1	1.77e-04	37	59	3	GO:0045505
Domain	PDED_dom	UNC119 UNC119B	2.74e-05	3	57	2	IPR008015
Domain	GMP_PDE_delta	UNC119 UNC119B	2.74e-05	3	57	2	PF05351
Domain	-	UNC119 UNC119B	2.74e-05	3	57	2	2.70.50.40
Domain	EXOIII	REXO5 PAN2	8.13e-04	14	57	2	SM00479
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DNAH1	8.13e-04	14	57	2	IPR024317
Domain	Exonuclease_RNaseT/DNA_pol3	REXO5 PAN2	8.13e-04	14	57	2	IPR013520
Domain	RNase_T	REXO5 PAN2	8.13e-04	14	57	2	PF00929
Domain	Dynein_HC_stalk	DYNC2H1 DNAH1	8.13e-04	14	57	2	IPR024743
Domain	Dynein_heavy_dom-2	DYNC2H1 DNAH1	8.13e-04	14	57	2	IPR013602
Domain	DHC_N2	DYNC2H1 DNAH1	8.13e-04	14	57	2	PF08393
Domain	MT	DYNC2H1 DNAH1	8.13e-04	14	57	2	PF12777
Domain	AAA_8	DYNC2H1 DNAH1	8.13e-04	14	57	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DYNC2H1 DNAH1	8.13e-04	14	57	2	IPR011704
Domain	AAA_5	DYNC2H1 DNAH1	8.13e-04	14	57	2	PF07728
Domain	DHC_fam	DYNC2H1 DNAH1	9.37e-04	15	57	2	IPR026983
Domain	Dynein_heavy_dom	DYNC2H1 DNAH1	9.37e-04	15	57	2	IPR004273
Domain	Dynein_heavy	DYNC2H1 DNAH1	9.37e-04	15	57	2	PF03028
Domain	-	ATP1A1 ATP2B1	1.07e-03	16	57	2	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP1A1 ATP2B1	1.07e-03	16	57	2	IPR023298
Domain	ATPase_P-typ_cation-transptr_C	ATP1A1 ATP2B1	1.21e-03	17	57	2	IPR006068
Domain	Cation_ATPase_C	ATP1A1 ATP2B1	1.21e-03	17	57	2	PF00689
Domain	Cation_ATPase_N	ATP1A1 ATP2B1	1.36e-03	18	57	2	PF00690
Domain	Cation_ATPase_N	ATP1A1 ATP2B1	1.36e-03	18	57	2	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP1A1 ATP2B1	1.51e-03	19	57	2	IPR004014
Domain	-	ATP1A1 ATP2B1	4.28e-03	32	57	2	3.40.1110.10
Domain	-	ATP1A1 ATP2B1	4.28e-03	32	57	2	2.70.150.10
Domain	ATPase_P-typ_cyto_domN	ATP1A1 ATP2B1	5.10e-03	35	57	2	IPR023299
Domain	P_typ_ATPase	ATP1A1 ATP2B1	5.39e-03	36	57	2	IPR001757
Domain	ATPase_P-typ_P_site	ATP1A1 ATP2B1	5.39e-03	36	57	2	IPR018303
Domain	ATPASE_E1_E2	ATP1A1 ATP2B1	5.39e-03	36	57	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP1A1 ATP2B1	5.69e-03	37	57	2	IPR008250
Domain	E1-E2_ATPase	ATP1A1 ATP2B1	5.69e-03	37	57	2	PF00122
Domain	-	REXO5 PAN2	9.06e-03	47	57	2	3.30.420.10
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DYNC2H1 DNAH17 DNAH1	1.67e-06	14	59	3	9373155
Pubmed	KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia.	NTRK1 KDM6A	8.48e-06	3	59	2	33456567
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	IPO5 BRCA1 SBF2 USP9Y	1.50e-05	87	59	4	17148452
Pubmed	Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility.	USP9Y KDM6A	1.69e-05	4	59	2	10767340
Pubmed	Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.	UNC119 UNC119B	2.82e-05	5	59	2	22960633
Pubmed	Threonine phosphorylation sites in the beta 2 and beta 7 leukocyte integrin polypeptides.	PRKCD ITGA4	4.23e-05	6	59	2	12682249
Pubmed	An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.	UNC119 UNC119B	5.91e-05	7	59	2	22085962
Pubmed	POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.	ATP1A1 ATP2B1	5.91e-05	7	59	2	22084111
Pubmed	Characterization of LGALS3 (galectin-3) as a player in DNA damage response.	IPO5 BRCA1 ATP1A1	6.68e-05	46	59	3	24755837
Pubmed	The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function.	UNC119 UNC119B	7.87e-05	8	59	2	26455799
Pubmed	The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase.	PHKG2 PRKCD	7.87e-05	8	59	2	8999860
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	JCAD ACAD11 DYNC2H1 SRP68 CSMD2 ATP2B1 KDM6A	1.01e-04	638	59	7	31182584
Pubmed	Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening.	PHKG2 PRKCD	1.26e-04	10	59	2	25495526
Pubmed	ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.	BRCA1 NTRK1 MYBPC3	1.27e-04	57	59	3	23788249
Pubmed	Preliminary evidence of phenytoin-induced alterations in embryonic gene expression in a mouse model.	NTRK1 TGFA	1.54e-04	11	59	2	7841657
Pubmed	Identification of integrin-alpha4, Rb1, and syncytin a as murine placental target genes of the transcription factor GCMa/Gcm1.	VNN1 ITGA4	1.85e-04	12	59	2	18167345
Pubmed	Voxelwise genome-wide association study (vGWAS).	CADPS2 CSMD2	2.93e-04	15	59	2	20171287
Pubmed	Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method.	ACAD11 DYNC2H1	2.93e-04	15	59	2	12056414
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	USP9Y KDM6A	4.25e-04	18	59	2	12023983
Pubmed	Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation.	ATP1A1 ITGA4	4.25e-04	18	59	2	12519789
Pubmed	Coronavirus subverts ER-phagy by hijacking FAM134B and ATL3 into p62 condensates to facilitate viral replication.	SEL1L ATP1A1	4.75e-04	19	59	2	36952345
Pubmed	Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.	ASCC2 KDM6A	5.27e-04	20	59	2	19047629
Pubmed	The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation.	TSHZ3 ATP1A1 TGFA	5.74e-04	95	59	3	20843830
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	JCAD TSHZ3 OSBPL8	7.27e-04	103	59	3	10819331
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	EFR3B OSBPL8 ATP1A1 ITGA4 ATP2B1	7.43e-04	421	59	5	36976175
Pubmed	Functional coherence of the human Y chromosome.	USP9Y KDM6A	8.28e-04	25	59	2	9381176
Pubmed	Motor innervation directs the correct development of the mouse sympathetic nervous system.	NTRK1 ITGA4	8.28e-04	25	59	2	39152112
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	SEL1L IPO5 OSBPL8 SRP68 ATP1A1 CADPS2	8.56e-04	657	59	6	36180527
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	UNC119 UNC119B PHKG2 ACAD11 OSBPL8 PRKCD DDX43	8.57e-04	910	59	7	36736316
Pubmed	Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.	KCTD4 ABTB2	9.66e-04	27	59	2	30404837
Pubmed	Loss of Super-Enhancer-Regulated circRNA Nfix Induces Cardiac Regeneration After Myocardial Infarction in Adult Mice.	ATP1A1 MYBPC3	1.04e-03	28	59	2	30947518
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	NLRP9 SYNE3 DDX60 EFR3B PAN2 KDM6A	1.07e-03	686	59	6	29987050
Pubmed	Biology, structure and mechanism of P-type ATPases.	ATP1A1 ATP2B1	1.12e-03	29	59	2	15071553
Pubmed	DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.	JCAD UNC119B KIAA0232	1.19e-03	122	59	3	30773093
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	IPO5 EFR3B OSBPL8 SRP68 ATP1A1 ATP2B1	1.26e-03	708	59	6	39231216
Pubmed	Altered gene expression in murine branchial arches following in utero exposure to retinoic acid.	NTRK1 TGFA	1.27e-03	31	59	2	7601910
Pubmed	Developmental expression of morphoregulatory genes in the mouse embryo: an analytical approach using a novel technology.	NTRK1 TGFA	1.27e-03	31	59	2	9169087
Pubmed	Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia.	NTRK1 SRP68	1.62e-03	35	59	2	38025786
Cytoband	15q26.3	LINS1 TARS3	1.29e-03	41	59	2	15q26.3
GeneFamily	Dyneins, axonemal	DNAH17 DNAH1	6.04e-04	17	39	2	536
CoexpressionAtlas	dev gonad_e13.5_M_SertoliCell_Sox9_top-relative-expression-ranked_1000	UNC119 JCAD TARS3 REXO5 BRCA1 VNN1 PRKCD ATP1A1 ABTB2 ZMYM3 MYBPC3	1.57e-05	880	56	11	gudmap_dev gonad_e13.5_M_SertoliCell_Sox9_1000
CoexpressionAtlas	dev gonad_e13.5_M_SertoliCell_Sox9_k-means-cluster#4_top-relative-expression-ranked_1000	UNC119 TARS3 REXO5 VNN1 ATP1A1 ABTB2 ZMYM3 MYBPC3	3.22e-05	474	56	8	gudmap_dev gonad_e13.5_M_SertoliCell_Sox9_k4_1000
CoexpressionAtlas	dev gonad_e12.5_M_SertoliCell_Sox9_top-relative-expression-ranked_1000	UNC119 JCAD TARS3 REXO5 BRCA1 VNN1 ATP1A1 ITGA4 ABTB2 ZMYM3	9.28e-05	884	56	10	gudmap_dev gonad_e12.5_M_SertoliCell_Sox9_1000
CoexpressionAtlas	DevelopingKidney_e15.5_Pelvic Mesenchyme_emap-8241_top-relative-expression-ranked_500	SEL1L RGMB TSHZ3 VNN1 NTRK1 CADPS2 ATP2B1	1.01e-04	412	56	7	gudmap_developingKidney_e15.5_Pelvic Mesenchyme_500
CoexpressionAtlas	dev gonad_e12.5_M_SertoliCell_Sox9_top-relative-expression-ranked_500	UNC119 JCAD TARS3 VNN1 ATP1A1 ABTB2 ZMYM3	1.53e-04	441	56	7	gudmap_dev gonad_e12.5_M_SertoliCell_Sox9_500
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Calb1_(Superficial_layer_pyramidal_cells--Layer_2/3)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	A4GNT SAMD3 ATP1A1 KISS1 MYBPC3	7.05e-07	126	59	5	7dcc79bf35482e8e5e5a1de7279ba080edb70522
Disease	coronary artery disease, plasminogen activator inhibitor 1 measurement	JCAD DYNC2H1 ATP2B1	2.25e-04	63	55	3	EFO_0001645, EFO_0004792
Disease	Schizophreniform Disorders	RBM12 NTRK1	3.06e-04	14	55	2	C0036358
Disease	Psychosis, Brief Reactive	RBM12 NTRK1	3.06e-04	14	55	2	C0033958
Disease	tissue plasminogen activator measurement, coronary artery disease	JCAD DYNC2H1 ATP2B1	3.20e-04	71	55	3	EFO_0001645, EFO_0004791
Disease	Lung Injury	NTRK1 TGFA	7.00e-04	21	55	2	C0273115
Disease	Chronic Lung Injury	NTRK1 TGFA	7.00e-04	21	55	2	C2350344
Disease	pancreatic cancer (is_marker_for)	NTRK1 A4GNT TGFA	8.97e-04	101	55	3	DOID:1793 (is_marker_for)
Disease	coronary artery disease, factor VII measurement	JCAD DYNC2H1 ATP2B1	1.18e-03	111	55	3	EFO_0001645, EFO_0004619
Disease	pancreatic cancer (is_implicated_in)	SEL1L BRCA1 ITGA4	1.21e-03	112	55	3	DOID:1793 (is_implicated_in)
Disease	factor VIII measurement, coronary artery disease	JCAD DYNC2H1 ATP2B1	1.24e-03	113	55	3	EFO_0001645, EFO_0004630
Disease	factor XI measurement, coronary artery disease	JCAD DYNC2H1 ATP2B1	1.31e-03	115	55	3	EFO_0001645, EFO_0004694
Disease	Schizoaffective Disorder	RBM12 NTRK1	1.34e-03	29	55	2	C0036337
Disease	von Willebrand factor measurement, coronary artery disease	JCAD DYNC2H1 ATP2B1	1.41e-03	118	55	3	EFO_0001645, EFO_0004629
Disease	Vasodilators used in cardiac diseases use measurement	DYNC2H1 ATP2B1	1.84e-03	34	55	2	EFO_0009926

Protein segments in the cluster

Peptide	Gene	Start	Entry
LHFSSFELIKCEDPG	CSMD2	1201	Q7Z408
DIFPLACQTFQKHDF	ASCC2	261	Q9H1I8
LSQELFHSGCFLFPF	GJA10	491	Q969M2
FCLPSFKSHQGLEAL	A4GNT	31	Q9UNA3
HPGEDFLCLEGKDFN	ATP2B1	726	P20020
GDFRLDNIVFHPKEC	ACAD11	221	Q709F0
HEAGFCVYLKGLPFE	RBM12	426	Q9NTZ6
QKEFCLACELGFLFH	PAN2	551	Q504Q3
FGKVFLAECHNLLPE	NTRK1	521	P04629
PHCIFLFFLKNIGFD	LINS1	491	Q8NG48
SGFAPVFLQFLDCVH	SBF2	1466	Q86WG5
AGFSFVNPKFEHLLE	PRKCD	661	Q05655
NLDNLSCFHPADIFG	CSRNP1	416	Q96S65
GDFLNVVGFPLNHFC	ASMTL	191	O95671
RVLGFCHLFLPDEQF	ATP1A1	551	P05023
CHLFLPDEQFPEGFQ	ATP1A1	556	P05023
LRHFKLAQPQGFCED	JCAD	431	Q9P266
ENKRDAFFPPLHQFC	KDM6A	946	O15550
ICEISFKPGQNLHFF	DDX60	51	Q8IY21
KGFSFIFHEDLLGAC	KIAA0232	1011	Q92628
FQKAPFEEIAAHCGA	EFR3B	751	Q9Y2G0
KILCPFDADGHYFID	KCTD4	66	Q8WVF5
LFLCATHFGEPLEKV	KISS1	11	Q15726
THDGFFSLELLCPFF	RFPL4B	231	Q6ZWI9
FKHFADLLPGFLQAV	IPO5	211	O00410
DFGFSCHLEPGEKLR	PHKG2	171	P15735
DGFCFKLFHPLEQSI	OSBPL8	206	Q9BZF1
EELPCFQHLLFGKVN	BRCA1	1221	P38398
PDREEFLFCLFKHLC	CFAP300	161	Q9BRQ4
LQDPGHFLESLFKFD	DNAH1	2986	Q9P2D7
PGFRCFHQSAKDLLD	DYNC2H1	511	Q8NCM8
GDELLFAKPNIFCHF	DNAH17	2721	Q9UFH2
DEFISANPCKLDHAF	CADPS2	631	Q86UW7
ANPFHLSGDVDFFLL	CFAP100	51	Q494V2
IKADPHCLNFLCNFG	ITGA4	891	P13612
HTFLQNFKGDFVDPC	FAAH	386	O00519
TFCDFPKINHGILYD	CFHR1	21	Q03591
EELPLCFALKSHFVG	DDX43	66	Q9NXZ2
DKSQFLFRNPHCDLG	FAM166A	246	Q6J272
GKEQELFFFHDLSPG	TARS3	406	A2RTX5
LFCGLFGDPHLRTFK	RGMB	161	Q6NW40
LLAQHKDFGAAFEPL	SYNE3	546	Q6ZMZ3
PCHFPFLFLDKEYDE	SEL1L	126	Q9UBV2
QAHPFLDEDGCGFFL	SAMD3	206	Q8N6K7
CKPLFFDLALNHVAF	SRP68	586	Q9UHB9
IHNAPELALFCEGFF	ABTB2	961	Q8N961
TVPFLKHGFCENLDD	CCDC110	226	Q8TBZ0
FNFVRDNGPLFILCH	NLRP9	321	Q7RTR0
ECGKAFDRPSLFQIH	ZNF564	201	Q8TBZ8
FHGTCRFLVQEDKPA	TGFA	56	P01135
ECGKAFIFPSFLRVH	ZNF791	276	Q3KP31
LLKSFDFHFGFCIPS	UNC119	171	Q13432
FGIFTCFDILFHDPA	VNN1	206	O95497
HFPLQGFPDCENFLL	REXO5	201	Q96IC2
HLLKNFDFDFGFCIP	UNC119B	181	A6NIH7
FSPGQLDHLFDCFKA	USP9Y	461	O00507
LKNLDTGHPVFFCND	TSHZ3	966	Q63HK5
FGDFFQPCVLHAVEK	TCHHL1	41	Q5QJ38
HSLFVFIIPENFKGC	SOHLH2	96	Q9NX45
GPELLFHEGQQKRFC	ZMYM3	466	Q14202
FVPEGFACNLSAKLH	MYBPC3	616	Q14896