Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Ank	CDKN2C ANKFY1 ANK1 ANKRD23 LRRK1 ANKHD1 ANKRD27 ANKRD13C ASB9 NFKBIL1 TNKS OSTF1 TNKS2	7.89e-10	228	109	13	PF00023
Domain	ANK	CDKN2C ANKFY1 ANK1 ANKRD23 LRRK1 ANKHD1 ANKRD27 ANKRD13C ASB9 NFKBIL1 TNKS OSTF1 TNKS2	2.55e-09	251	109	13	SM00248
Domain	ANK_REPEAT	CDKN2C ANKFY1 ANK1 ANKRD23 LRRK1 ANKHD1 ANKRD27 ANKRD13C ASB9 NFKBIL1 TNKS OSTF1 TNKS2	2.80e-09	253	109	13	PS50088
Domain	Ankyrin_rpt-contain_dom	CDKN2C ANKFY1 ANK1 ANKRD23 LRRK1 ANKHD1 ANKRD27 ANKRD13C ASB9 NFKBIL1 TNKS OSTF1 TNKS2	2.94e-09	254	109	13	IPR020683
Domain	ANK_REP_REGION	CDKN2C ANKFY1 ANK1 ANKRD23 LRRK1 ANKHD1 ANKRD27 ANKRD13C ASB9 NFKBIL1 TNKS OSTF1 TNKS2	2.94e-09	254	109	13	PS50297
Domain	Ankyrin_rpt	CDKN2C ANKFY1 ANK1 ANKRD23 LRRK1 ANKHD1 ANKRD27 ANKRD13C ASB9 NFKBIL1 TNKS OSTF1 TNKS2	4.27e-09	262	109	13	IPR002110
Domain	-	CDKN2C ANKFY1 ANK1 ANKRD23 LRRK1 ANKRD27 ANKRD13C ASB9 NFKBIL1 TNKS OSTF1 TNKS2	2.31e-08	248	109	12	1.25.40.20
Domain	Ank_3	ANK1 ANKRD23 ANKRD27 TNKS	2.24e-07	10	109	4	PF13606
Domain	Ank_2	ANKFY1 ANK1 ANKRD23 LRRK1 ANKRD27 ANKRD13C ASB9 TNKS OSTF1 TNKS2	5.24e-07	215	109	10	PF12796
Domain	Spectrin_repeat	DRP2 SPTBN5 MACF1 PLEC	2.33e-05	29	109	4	IPR002017
Domain	Spectrin/alpha-actinin	DRP2 SPTBN5 MACF1 PLEC	3.48e-05	32	109	4	IPR018159
Domain	SPEC	DRP2 SPTBN5 MACF1 PLEC	3.48e-05	32	109	4	SM00150
Domain	CH	MICALL1 SPTBN5 MACF1 LIMCH1 PLEC	3.86e-05	65	109	5	SM00033
Domain	CH	MICALL1 SPTBN5 MACF1 LIMCH1 PLEC	5.53e-05	70	109	5	PF00307
Domain	-	MICALL1 SPTBN5 MACF1 LIMCH1 PLEC	5.92e-05	71	109	5	1.10.418.10
Domain	CH	MICALL1 SPTBN5 MACF1 LIMCH1 PLEC	6.76e-05	73	109	5	PS50021
Domain	CH-domain	MICALL1 SPTBN5 MACF1 LIMCH1 PLEC	7.70e-05	75	109	5	IPR001715
Domain	Actinin_actin-bd_CS	SPTBN5 MACF1 PLEC	3.15e-04	23	109	3	IPR001589
Domain	Spectrin	DRP2 SPTBN5 MACF1	3.15e-04	23	109	3	PF00435
Domain	ACTININ_2	SPTBN5 MACF1 PLEC	3.15e-04	23	109	3	PS00020
Domain	ACTININ_1	SPTBN5 MACF1 PLEC	3.15e-04	23	109	3	PS00019
Domain	-	MACF1 PLEC	4.99e-04	6	109	2	3.90.1290.10
Domain	Plectin_repeat	MACF1 PLEC	6.95e-04	7	109	2	IPR001101
Domain	Plectin	MACF1 PLEC	6.95e-04	7	109	2	PF00681
Domain	PLEC	MACF1 PLEC	6.95e-04	7	109	2	SM00250
Domain	Cadherin_CS	PCDHGA2 PCDHA8 CDH9 CDH15	3.82e-03	109	109	4	IPR020894
Domain	TLC	CLN8 CERS3	3.84e-03	16	109	2	PS50922
Domain	TLC	CLN8 CERS3	3.84e-03	16	109	2	SM00724
Domain	TRAM_LAG1_CLN8	CLN8 CERS3	3.84e-03	16	109	2	PF03798
Domain	TLC-dom	CLN8 CERS3	3.84e-03	16	109	2	IPR006634
Domain	Poly(ADP-ribose)pol_cat_dom	TNKS TNKS2	4.33e-03	17	109	2	IPR012317
Domain	PARP_CATALYTIC	TNKS TNKS2	4.33e-03	17	109	2	PS51059
Domain	Homeobox_KN	TGIF2LY TGIF2LX	4.33e-03	17	109	2	PF05920
Domain	PARP	TNKS TNKS2	4.33e-03	17	109	2	PF00644
Domain	Homeobox_KN_domain	TGIF2LY TGIF2LX	4.33e-03	17	109	2	IPR008422
Domain	-	TNKS TNKS2	4.33e-03	17	109	2	3.90.228.10
Domain	CADHERIN_1	PCDHGA2 PCDHA8 CDH9 CDH15	4.34e-03	113	109	4	PS00232
Domain	Cadherin	PCDHGA2 PCDHA8 CDH9 CDH15	4.34e-03	113	109	4	PF00028
Domain	CADHERIN_2	PCDHGA2 PCDHA8 CDH9 CDH15	4.48e-03	114	109	4	PS50268
Domain	-	PCDHGA2 PCDHA8 CDH9 CDH15	4.48e-03	114	109	4	2.60.40.60
Domain	CA	PCDHGA2 PCDHA8 CDH9 CDH15	4.62e-03	115	109	4	SM00112
Domain	Cadherin-like	PCDHGA2 PCDHA8 CDH9 CDH15	4.76e-03	116	109	4	IPR015919
Domain	Cadherin	PCDHGA2 PCDHA8 CDH9 CDH15	5.06e-03	118	109	4	IPR002126
Pubmed	Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling.	STK11 TNKS TNKS2	1.13e-06	7	112	3	31554794
Pubmed	Tankyrase is necessary for canonical Wnt signaling during kidney development.	TNKS TNKS2	1.03e-05	2	112	2	20549720
Pubmed	Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.	TNKS TNKS2	1.03e-05	2	112	2	18612384
Pubmed	Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy.	TNKS TNKS2	1.03e-05	2	112	2	28723574
Pubmed	Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling.	TNKS TNKS2	1.03e-05	2	112	2	27494558
Pubmed	Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients.	TNKS TNKS2	1.03e-05	2	112	2	18026951
Pubmed	Expression of a novel TGIF subclass homeobox gene, Tex1, in the spermatids of mouse testis during spermatogenesis.	TGIF2LY TGIF2LX	1.03e-05	2	112	2	11960710
Pubmed	Association of TGIFLX/Y mRNA expression with prostate cancer.	TGIF2LY TGIF2LX	1.03e-05	2	112	2	18663611
Pubmed	The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon.	TGIF2LY TGIF2LX	1.03e-05	2	112	2	12226713
Pubmed	Structural insights into SAM domain-mediated tankyrase oligomerization.	TNKS TNKS2	1.03e-05	2	112	2	27328430
Pubmed	Association of TGIFLX/Y mRNA expression with azoospermia in infertile men.	TGIF2LY TGIF2LX	1.03e-05	2	112	2	18384077
Pubmed	Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.	TNKS TNKS2	1.03e-05	2	112	2	24116873
Pubmed	Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1.	TNKS TNKS2	1.03e-05	2	112	2	15795250
Pubmed	Regulation of tankyrase activity by a catalytic domain dimer interface.	TNKS TNKS2	1.03e-05	2	112	2	30055800
Pubmed	Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation.	TNKS TNKS2	1.03e-05	2	112	2	29263426
Pubmed	Molecular insights on TNKS1/TNKS2 and inhibitor-IWR1 interactions.	TNKS TNKS2	1.03e-05	2	112	2	24291818
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ANKFY1 HDAC4 GOLGA8K GATAD2B AGO3 ATF7IP SVIL MACF1 TNKS LIMCH1 GOLGA8A CNOT1 NIPBL	1.41e-05	963	112	13	28671696
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	CDKN2C HDAC4 RASGRF2 RBBP4 NDN LRRK1 MAST2 MRPS22 MICALL1 MRFAP1 NFKBIL1 DDRGK1 OSTF1 CNOT1 KLC3	1.63e-05	1284	112	15	17353931
Pubmed	SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis.	GOLGA8K SLC24A2 GOLGA8A	1.77e-05	16	112	3	18166528
Pubmed	Protein kinase LKB1 regulates polarized dendrite formation of adult hippocampal newborn neurons.	GOLGA8K STK11 GOLGA8A	2.56e-05	18	112	3	24367100
Pubmed	Adipocyte Liver Kinase b1 Suppresses Beige Adipocyte Renaissance Through Class IIa Histone Deacetylase 4.	HDAC4 STK11	3.08e-05	3	112	2	28882900
Pubmed	Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation.	TNKS TNKS2	3.08e-05	3	112	2	32442396
Pubmed	Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells.	TNKS TNKS2	3.08e-05	3	112	2	26246473
Pubmed	Processing of neuregulin-1 by neuropsin regulates GABAergic neuron to control neural plasticity of the mouse hippocampus.	NRG1 KLK8	3.08e-05	3	112	2	22972991
Pubmed	Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.	TNKS TNKS2	3.08e-05	3	112	2	33361107
Pubmed	Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.	TNKS TNKS2	3.08e-05	3	112	2	11739745
Pubmed	Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.	TNKS TNKS2	3.08e-05	3	112	2	25939383
Pubmed	Tankyrase inhibition aggravates kidney injury in the absence of CD2AP.	TNKS TNKS2	3.08e-05	3	112	2	27441654
Pubmed	Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex.	TNKS TNKS2	3.08e-05	3	112	2	33923443
Pubmed	TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression.	TNKS TNKS2	3.08e-05	3	112	2	11454873
Pubmed	Mapping of the motor neuron degeneration (Mnd) gene, a mouse model of amyotrophic lateral sclerosis (ALS).	CLN8 ANK1	3.08e-05	3	112	2	1639406
Pubmed	Necdin and neurotrophin receptors: interactors of relevance for neuronal resistance to oxidant stress.	NDN TNFRSF1B	3.08e-05	3	112	2	21150695
Pubmed	Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.	TNKS TNKS2	3.08e-05	3	112	2	21251231
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	ANKFY1 RASGRF2 ANKRD23 MAST2 MRFAP1 MACF1 TNKS PLEC TNKS2	3.46e-05	497	112	9	23414517
Pubmed	Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment.	GOLGA8K STK11 GOLGA8A	5.49e-05	23	112	3	21111240
Pubmed	Molecular cloning of a mouse scavenger receptor with C-type lectin (SRCL)(1), a novel member of the scavenger receptor family.	TGIF2LY TGIF2LX	6.14e-05	4	112	2	11718900
Pubmed	PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis.	TNKS TNKS2	6.14e-05	4	112	2	38272024
Pubmed	EHD3 Protein Is Required for Tubular Recycling Endosome Stabilization, and an Asparagine-Glutamic Acid Residue Pair within Its Eps15 Homology (EH) Domain Dictates Its Selective Binding to NPF Peptides.	ANKFY1 MICALL1	6.14e-05	4	112	2	27189942
Pubmed	The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182).	TNKS TNKS2	6.14e-05	4	112	2	11854288
Pubmed	A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2.	HIVEP3 TNFRSF1B	6.14e-05	4	112	2	11804591
Pubmed	Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death.	TNKS TNKS2	6.14e-05	4	112	2	30260955
Pubmed	Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation.	NRG1 KLK8	6.14e-05	4	112	2	28267150
Pubmed	Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR.	DDRGK1 EIF2AK3	6.14e-05	4	112	2	30842412
Pubmed	E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling.	TNKS TNKS2	6.14e-05	4	112	2	26513298
Pubmed	Poly-ADP ribosylation of p21 by tankyrases promotes p21 degradation and regulates cell cycle progression.	TNKS TNKS2	6.14e-05	4	112	2	36383218
Pubmed	Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14.	TNKS TNKS2	6.14e-05	4	112	2	11278563
Pubmed	HDAC4 and 5 repression of TBX5 is relieved by protein kinase D1.	HDAC4 TBX5	6.14e-05	4	112	2	31784580
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	HDAC4 MAST2 MACF1 KATNIP MBD5	6.58e-05	130	112	5	12421765
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	LCA5 DHX40 CIP2A MAST2 MICALL1 AGO3 SVIL CEP295 MPHOSPH9 PLEC CNOT1	1.00e-04	853	112	11	28718761
Pubmed	The Y172 Monoclonal Antibody Against p-c-Jun (Ser63) Is a Marker of the Postsynaptic Compartment of C-Type Cholinergic Afferent Synapses on Motoneurons.	NRG1 GOLGA8K GOLGA8A	1.00e-04	28	112	3	32038174
Pubmed	Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase).	TNKS TNKS2	1.02e-04	5	112	2	11802774
Pubmed	Tankyrase represses autoinflammation through the attenuation of TLR2 signaling.	TNKS TNKS2	1.02e-04	5	112	2	35362478
Pubmed	Expression pattern of TG-interacting factor 2 during mouse development.	TGIF2LY TGIF2LX	1.02e-04	5	112	2	15749073
Pubmed	The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation.	TNKS TNKS2	1.02e-04	5	112	2	22473005
Pubmed	A molecular network for the transport of the TI-VAMP/VAMP7 vesicles from cell center to periphery.	ANKRD27 MACF1	1.02e-04	5	112	2	22705394
Pubmed	Rabankyrin-5 interacts with EHD1 and Vps26 to regulate endocytic trafficking and retromer function.	ANKFY1 MICALL1	1.02e-04	5	112	2	22284051
Pubmed	Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly Inherited GH Deficiency in Humanized GH1 Mouse Models.	GOLGA8K GOLGA8A EIF2AK3	1.12e-04	29	112	3	31436800
Pubmed	Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.	RBBP4 DHX40 PSMB2 SRCIN1 DDRGK1 OSTF1 MBD5 CNOT1	1.32e-04	463	112	8	27503909
Pubmed	The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route.	GOLGA8K SPTBN5 GOLGA8A	1.51e-04	32	112	3	23704327
Pubmed	Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.	TNKS TNKS2	1.53e-04	6	112	2	19759537
Pubmed	Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.	TNKS TNKS2	1.53e-04	6	112	2	21799911
Pubmed	Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs.	TNKS TNKS2	1.53e-04	6	112	2	26845027
Pubmed	SUMO modification enhances p66-mediated transcriptional repression of the Mi-2/NuRD complex.	RBBP4 GATAD2B	1.53e-04	6	112	2	16738318
Pubmed	Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles.	TNKS TNKS2	1.53e-04	6	112	2	10988299
Pubmed	Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction of GPR motifs with Gi alpha.	STK11 MACF1	1.53e-04	6	112	2	12719437
Pubmed	The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases.	HDAC4 STK11	1.53e-04	6	112	2	23393134
Pubmed	Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs.	TNKS TNKS2	1.53e-04	6	112	2	34128958
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	ANKHD1 PDCD5 SVIL MACF1 PLEC NIPBL PBXIP1	1.72e-04	360	112	7	33111431
Pubmed	Human transcription factor protein interaction networks.	ATXN7L2 PITRM1 DHX40 PSMB2 HIC2 ANKHD1 MRPS22 GATAD2B AGO3 ATF7IP PDCD5 SVIL CNOT1 NIPBL	2.05e-04	1429	112	14	35140242
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	NRG1 ERCC6 ANK1 RASGRF2 SRCIN1 USP9Y LIMCH1 CNOT1	2.13e-04	497	112	8	36774506
Pubmed	Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4.	HDAC4 STK11	2.14e-04	7	112	2	24768298
Pubmed	Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism.	TNKS TNKS2	2.14e-04	7	112	2	22153076
Pubmed	Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth.	TNKS TNKS2	2.14e-04	7	112	2	25547115
Pubmed	RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.	TNKS TNKS2	2.14e-04	7	112	2	21478859
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ERCC6 ATXN7L2 RBBP4 HIC2 ANKHD1 MAST2 GATAD2B AGO3 NFKBIL1 MACF1 CEP295 CDH15	2.61e-04	1116	112	12	31753913
Pubmed	Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling.	HDAC4 STK11	2.84e-04	8	112	2	31430259
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PITRM1 HIC2 SRCIN1 LRRK1 ANKHD1 ANKRD27 MICALL1 CNOT1	3.24e-04	529	112	8	14621295
Pubmed	Transcription-coupled nucleotide excision repair is coordinated by ubiquitin and SUMO in response to ultraviolet irradiation.	ERCC6 RBBP4 MRPS22 GATAD2B	3.40e-04	102	112	4	31722399
Pubmed	Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.	TNKS TNKS2	3.65e-04	9	112	2	12080061
Pubmed	Identification and functional characterization of the p66/p68 components of the MeCP1 complex.	RBBP4 GATAD2B	3.65e-04	9	112	2	11756549
Pubmed	Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis.	TNKS TNKS2	3.65e-04	9	112	2	19766477
Pubmed	Complex genetic predisposition in adult and juvenile rheumatoid arthritis.	NFKBIL1 TNFRSF1B	3.65e-04	9	112	2	15018649
Pubmed	Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4.	RBBP4 CORO6 PLEC	3.65e-04	43	112	3	30026490
Pubmed	Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.	ERCC6 RBBP4 GATAD2B	3.65e-04	43	112	3	26030138
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	PITRM1 HIC2 ANKHD1 LIMCH1	3.66e-04	104	112	4	10470851
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	ZC3H14 RBBP4 DHX40 GOLGA8K MRPS22 BYSL DDRGK1 PLEC GOLGA8A	4.53e-04	701	112	9	30196744
Pubmed	Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.	CDH9 CDH15	4.55e-04	10	112	2	10861224
Pubmed	Increased interaction between DJ-1 and the Mi-2/ nucleosome remodelling and deacetylase complex during cellular stress.	RBBP4 GATAD2B	4.55e-04	10	112	2	20127688
Pubmed	An imprinted gene network that controls mammalian somatic growth is down-regulated during postnatal growth deceleration in multiple organs.	SLC38A4 NDN	4.55e-04	10	112	2	18448610
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	ANKFY1 RBBP4 SRCIN1 GSDMA CNOT1 SLC27A2	4.68e-04	304	112	6	32235678
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	HDAC4 MAST2 ANKRD27 MICALL1 SVIL MACF1 LIMCH1 MPHOSPH9 PLEC KLC3	4.79e-04	861	112	10	36931259
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	CIP2A SRCIN1 MICALL1 SVIL NECTIN4 MACF1 LIMCH1 PLEC	5.01e-04	565	112	8	25468996
Pubmed	Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: The Women's Genome Health Study.	TNKS TNKS2	5.55e-04	11	112	2	20937264
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	GATAD2B MACF1 TNKS TNKS2	6.28e-04	120	112	4	31413325
Pubmed	Kinase signalling in excitatory neurons regulates sleep quantity and depth.	HDAC4 STK11	6.64e-04	12	112	2	36477539
Pubmed	NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment.	RBBP4 GATAD2B	6.64e-04	12	112	2	22560079
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	ZC3H14 RBBP4 CIP2A ANKHD1 GATAD2B	6.76e-04	215	112	5	35973513
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	MORN4 CIP2A ANKHD1 CCDC88B ARMC2 ANKRD27 GASK1B ANKRD13C LIMCH1	7.34e-04	750	112	9	11230166
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	ANK1 RNF19A SVIL MACF1 PLEC CNOT1	7.41e-04	332	112	6	37433992
Pubmed	Globozoospermia and lack of acrosome formation in GM130-deficient mice.	GOLGA8K GOLGA8A	7.83e-04	13	112	2	28055014
Interaction	PCBD2 interactions	TGIF2LY MRFAP1 CERS3 PBXIP1 KLC3	6.00e-06	48	109	5	int:PCBD2
Interaction	GPSM3 interactions	CDKN2C CHRDL2 DHX40 GATAD2B SVIL NIPBL	6.29e-06	84	109	6	int:GPSM3
GeneFamily	Ankyrin repeat domain containing	CDKN2C ANKFY1 ANK1 ANKRD23 ANKHD1 ANKRD27 ANKRD13C ASB9 TNKS OSTF1 TNKS2	2.13e-09	242	70	11	403
GeneFamily	EF-hand domain containing\|Plakins	MACF1 PLEC	4.08e-04	8	70	2	939
GeneFamily	Zinc fingers\|Zinc fingers PARP-type\|Poly(ADP-ribose) polymerases	TNKS TNKS2	1.94e-03	17	70	2	684
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDKN2C DDAH2 RBBP4 CIP2A ANKRD23 THSD1	3.59e-06	163	112	6	7864e966c228282b4b63c43164dba3faba21026d
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-skeletal_muscle_satellite_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHRDL2 DRP2 ANK1 SLC24A2 GREB1 CDH15	7.43e-06	185	112	6	5414a66169c39d09a67b1050aad5e61f46b3749a
ToppCell	facs-Tongue-nan-24m-Epithelial-suprabasal\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DDAH2 CERS3 KLK8 NECTIN4 GSDMA KLC3	8.14e-06	188	112	6	ed35e438796cef302b6787c111753425922792dc
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FBXO40 RGS7BP NDN GPC4 GREB1 TBX5	9.18e-06	192	112	6	2cc712186e37fb21a964c032765c36a8b4a852cf
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TMEM132C HIVEP3 MACF1 CORO6 LIMCH1 TBX5	9.46e-06	193	112	6	99525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TMEM132C HIVEP3 MACF1 CORO6 LIMCH1 TBX5	9.46e-06	193	112	6	b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell	COVID-19-COVID-19_Severe-Others-HSPC\|COVID-19_Severe / Disease, condition lineage and cell class	DDAH2 SPNS2 NDN ASB9 LIMCH1 SLC27A2	1.13e-05	199	112	6	25de67b6c9c8d6bb9a538e071a40ef865906c95d
Disease	programmed cell death protein 5 measurement	ANKRD27 PDCD5	1.25e-04	5	105	2	EFO_0801927
Disease	heart function measurement	RNF19A PLEC TBX5	2.42e-04	34	105	3	EFO_0004311
Disease	Malignant neoplasm of testis	STK11 ATF7IP	2.60e-04	7	105	2	C0153594
Disease	Testicular Neoplasms	STK11 ATF7IP	3.46e-04	8	105	2	C0039590
Disease	Malignant neoplasm of breast	CDKN2C NRG1 ERCC6 ANK1 HDAC4 RASGRF2 MRPS22 MICALL1 CLCN1 MACF1 NIPBL	1.55e-03	1074	105	11	C0006142
Disease	serum alanine aminotransferase measurement, response to combination chemotherapy	HDAC4 CEP295 GREB1	2.10e-03	71	105	3	EFO_0004735, EFO_0007965
Disease	intellectual disability (implicated_via_orthology)	ZC3H14 GATAD2B ATF7IP	2.45e-03	75	105	3	DOID:1059 (implicated_via_orthology)
Disease	hemoglobin A1 measurement	CDKN2C ANK1 MAST2 ANKRD27 HIVEP3 PDCD5 MACF1	2.61e-03	520	105	7	EFO_0007629
Disease	obsolete Mendelian syndromes with cleft lip/palate	RASGRF2 SVIL	3.02e-03	23	105	2	MONDO_0015335
Disease	Pseudoaphakia	ERCC6 TDRD7	3.29e-03	24	105	2	C0524524
Disease	Lens Opacities	ERCC6 TDRD7	3.29e-03	24	105	2	C1510497

Protein segments in the cluster

Peptide	Gene	Start	Entry
PQHRDADIVQGKGEA	ERICH3	781	Q5RHP9
ADVNQGKGQDSPLHA	ASB9	191	Q96DX5
LTDGGDPNAHDKLHR	ANKRD23	131	Q86SG2
FDHSPQGLVQKARDG	CCDC88B	511	A6NC98
LDGRIAALDPENHGK	EIF2AK3	111	Q9NZJ5
LERDAHPNAAGKNGL	ANK1	556	P16157
LDLHSQKPVGQRGEQ	ARMC2	576	Q8NEN0
APLGLQGSINHKEAV	GSDMA	181	Q96QA5
ISAENGKAPHLGREL	ANKRD13C	426	Q8N6S4
GNLNDSEGLNRKHIP	CCDC144CP	1146	Q8IYA2
NGRDPQALAKAVQIH	AGO3	836	Q9H9G7
LHNEELAGAGRVAQP	DDRGK1	36	Q96HY6
DEGHKIRNPNAAVTL	ERCC6	646	Q03468
KASQLENRGAAGHPA	ATXN7L2	641	Q5T6C5
QAHQKLAAISGPEDG	RGS7BP	101	Q6MZT1
RIPLKNAHDADVGEN	PCDHGA2	151	Q9Y5H1
KPNGHIANRLEVDSN	NRG1	551	Q02297
PLLLKHGANAGARNA	ANKRD27	761	Q96NW4
PGKLNEADHNGDLAL	ANKFY1	246	Q9P2R3
LGVNLNKNLGPHERA	FAXC	171	Q5TGI0
GEEQDLNVDHGLKPR	PCDHA8	786	Q9Y5H6
LDRLPGQKEAHAQAG	HDAC4	541	P56524
VDKRFLPDDNGHNAL	GREB1	136	Q4ZG55
KLNLSDNHLGELPGV	LRRK1	306	Q38SD2
GFNKNDAPLHEINGD	GPC4	41	O75487
LGHEREGNKPEQIGA	HERC3	66	Q15034
EGNKPEQIGALADQH	HERC3	71	Q15034
NGKLDKGDREAPADH	KATNIP	601	O60303
RQRLAELQAKHGDPG	PDCD5	11	O14737
ELQAKHGDPGDAAQQ	PDCD5	16	O14737
KAALDLAAGNHPDQG	PIN1P1	66	O15428
RNIHDNKVSGPLSGN	NIPBL	216	Q6KC79
QNQPKRAHVEDGGSR	MPHOSPH9	151	Q99550
ESQGAHQAGLAKVIP	KDM4E	36	B2RXH2
EKLDPGGLLNSDHRV	MACF1	596	O94854
QKQDRHGEAGILNPI	LCA5	371	Q86VQ0
HQQQLAEDAKDVPGG	MICALL1	241	Q8N3F8
GADHPDVAKQLNNLA	KLC3	326	Q6P597
PDRANKEHILHAGGV	ARMC7	86	Q9H6L4
EEKLNGNLRPHGDNR	GATAD2B	76	Q8WXI9
HGDNRTAGRPGKENI	GATAD2B	86	Q8WXI9
ALLQRHPGLDVDAGQ	NFKBIL1	51	Q9UBC1
KEAQHFRLLAGPHEG	CHRDL2	391	Q6WN34
ECNPDLRLRGHQKEG	RBBP4	166	Q09028
PKDEALAKLGINGAH	MYO15B	1121	Q96JP2
GRASLQHGQAAEKGP	GASK1B	56	Q6UWH4
NEGNLPLHLAAKEGH	CDKN2C	101	P42773
KNGLRAERHLIPNGQ	CERS3	366	Q8IU89
APQELGAADKHGDLR	GOLGA8K	561	D6RF30
HVAGKPRAGAANSQL	CUSTOS	41	Q96C57
KGQVVAEQARPHEGA	CORO6	206	Q6QEF8
VKLLNGNHENGDLDP	ATF7IP	41	Q6VMQ6
PELSEGRKNNHLLGH	FBXO40	551	Q9UH90
RKDPGANNHLESQGV	GPR142	86	Q7Z601
QEPGGHQKHRDLALV	MAST2	1776	Q6P0Q8
LPKNLDHGKNVNEGD	MBD5	1166	Q9P267
DQALQEAHRVLKPGG	COQ5	226	Q5HYK3
VRLGDHSLQNKDGPE	KLK8	81	O60259
LRGVADDQGQHPLLK	ATRIP	526	Q8WXE1
AHAGQLLGVPEQHRK	C9orf40	41	Q8IXQ3
GNLNDSEGLNRKHIP	CCDC144A	1336	A2RUR9
AGLPALDLAKAQREH	DDAH2	31	O95865
LDLAKAQREHGVLGG	DDAH2	36	O95865
GHRQAKENEPDLDAL	CEP295	96	Q9C0D2
VDGGFVKQLNHNPRL	DHX40	361	Q8IX18
HLGRIKANDPDVGEN	CDH9	286	Q9ULB4
GKGLLHGPQDDLRDN	CDH15	636	P55291
AARGVGGQEKHAPLA	BYSL	6	Q13895
GGQEKHAPLADQILA	BYSL	11	Q13895
RLKQLQDAHRDFGPG	DRP2	331	Q13474
ARVHGSPLELKQDNG	LIMCH1	596	Q9UPQ0
LNRDDLLHIGPGNKN	NUP210L	1431	Q5VU65
ESIDNPLHEAAKRGN	OSTF1	71	Q92882
HLQNPGDAAEGRAAK	MRFAP1	81	Q9Y605
EGHGKFLAAARNPAA	GOLGA8A	531	A7E2F4
QGLVDGRKGAHAPQE	HIC2	176	Q96JB3
VLHPDGQSAQGAKDQ	MRPS22	306	P82650
NNADTGRVLALPEHK	TGIF2LX	36	Q8IUE1
NNADTGRVLALPEHK	TGIF2LY	36	Q8IUE0
RLPKQSIGQFHEGDA	SVIL	1766	O95425
SGGRQGREQKQDPLH	TMEM132C	1031	Q8N3T6
PRLHIVKADENNGFG	TBX5	181	Q99593
RQNGAANHVEKIELP	SLC24A2	401	Q9UI40
QNNRGEHLVDGKSPR	RASGRF2	706	O14827
PNDRDHKVRLALGNG	SLC27A2	326	O14975
NHDGDPVELLKLGNQ	PITRM1	456	Q5JRX3
NGIHDLDNISFPKQG	PSMB2	186	P49721
VPATKRGHADQLGDQ	SPNS2	281	Q8IVW8
NNARLHVALPQGKGF	PRR32	156	B1ATL7
EASHNGQRRGLPKAV	STK11	376	Q15831
QSHKNGVALPRLQGE	TDRD7	16	Q8NHU6
HRNPAGLDENQAKGS	SLC38A4	291	Q969I6
KGEALLAQSHPRAGE	SPTBN5	2211	Q9NRC6
HANVEDRGNKGDITP	ANKHD1	261	Q8IWZ3
LGDPVLHADKARGQQ	CLN8	86	Q9UBY8
LHQVLGLLNGKDPDS	CIP2A	281	Q8TCG1
PSENGGLQHRLRKDA	CLCN1	36	P35523
LDHPGFQIRDSKGLH	CNOT1	361	A5YKK6
GAVSHPNGQEAKELL	ZSCAN5DP	336	P0CG00
HQPKGLEEENAQLRG	PBXIP1	301	Q96AQ6
AEEHGNNGIKPNVDL	RNF19A	796	Q9NV58
HTQGAQPGLADQAAK	SRCIN1	121	Q9C0H9
RKPDLGDHQAGLVAG	THSD1	736	Q9NS62
ADVNAQDKGGLIPLH	TNKS	861	O95271
PEKSHLGNQGQGRRE	HIVEP3	1481	Q5T1R4
AGEKAPRAQLDLQHP	TLE7	191	A0A1W2PR48
IHNALKGIPDDRDGL	USP9Y	2356	O00507
NDVQTLKDGRHPQGE	PLEC	591	Q15149
HGADVNAQDKGGLIP	TNKS2	701	Q9H2K2
NAQDKGGLIPLHNAA	TNKS2	706	Q9H2K2
KNSVLHRINPGENGL	ZNF229	251	Q9UJW7
HPKQQIGENLSRGDD	ZNF548	121	Q8NEK5
DKARGTQGPEQQHLL	TNFRSF1B	306	P20333
GHTKPVDLGGQDVRN	XPNPEP2	21	O43895
AASNKGLRGLLHPQQ	ZC3H14	551	Q6PJT7
GVPLAQRQLHAKEGA	WDR54	51	Q9H977
SHGIPRNEGLFENNK	MORN4	106	Q8NDC4
DPKALQQAAEEGRAH	NDN	66	Q99608
VGLRAEGHPDSLKDN	NECTIN4	416	Q96NY8