Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionalpha-tocopherol omega-hydroxylase activity

CYP4F8 CYP4F12 CYP4F11

4.11e-075703GO:0052871
GeneOntologyMolecularFunctionleukotriene-B4 20-monooxygenase activity

CYP4F8 CYP4F12 CYP4F11

1.43e-067703GO:0050051
GeneOntologyMolecularFunctionalkane 1-monooxygenase activity

CYP4F8 CYP4F12 CYP4F11

1.43e-067703GO:0018685
GeneOntologyMolecularFunctionarachidonate omega-hydroxylase activity

CYP4F8 CYP4F12 CYP4F11

4.86e-0610703GO:0052869
GeneOntologyMolecularFunctionfatty acid omega-hydroxylase activity

CYP4F8 CYP4F12 CYP4F11

4.86e-0610703GO:0120250
GeneOntologyMolecularFunctionlong-chain fatty acid omega-hydroxylase activity

CYP4F8 CYP4F12 CYP4F11

4.86e-0610703GO:0102033
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

CYP4F8 CYP4F12 CYP4F11

1.15e-0513703GO:0016713
GeneOntologyMolecularFunctionarachidonate binding

CYP4F8 CYP4F12 CYP4F11

1.82e-0515703GO:0050544
GeneOntologyMolecularFunctionicosanoid binding

CYP4F8 CYP4F12 CYP4F11

2.24e-0516703GO:0050542
GeneOntologyMolecularFunctionicosatetraenoic acid binding

CYP4F8 CYP4F12 CYP4F11

2.24e-0516703GO:0050543
GeneOntologyMolecularFunctionarachidonate epoxygenase activity

CYP4F8 CYP4F12 CYP4F11

7.92e-0524703GO:0008392
GeneOntologyMolecularFunctionarachidonate monooxygenase activity

CYP4F8 CYP4F12 CYP4F11

1.14e-0427703GO:0008391
GeneOntologyMolecularFunctionlong-chain fatty acid binding

CYP4F8 CYP4F12 CYP4F11

1.27e-0428703GO:0036041
GeneOntologyMolecularFunctionaromatase activity

CYP4F8 CYP4F12 CYP4F11

2.49e-0435703GO:0070330
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

CYP4F8 CYP4F12 CYP4F11

3.71e-0440703GO:0016709
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

CYP4F8 KDM3B CYP4F12 PLOD2 CYP4F11

5.97e-04194705GO:0016705
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP4F8 CYP4F12 CYP4F11

6.77e-0449703GO:0016712
GeneOntologyMolecularFunctionsiRNA binding

TLR9 DICER1

7.82e-0412702GO:0035197
GeneOntologyMolecularFunctionCARD domain binding

NOD1 MAVS

1.59e-0317702GO:0050700
GeneOntologyMolecularFunctionfatty acid binding

CYP4F8 CYP4F12 CYP4F11

1.83e-0369703GO:0005504
GeneOntologyMolecularFunctionhydrolase activity, acting on ester bonds

ENPP6 RNASE6 PXDNL LYPLA2 ENPP3 PLCH2 TNS2 DICER1 PPM1N

1.97e-03807709GO:0016788
GeneOntologyMolecularFunctionheme binding

CYP4F8 PXDNL CYP4F12 CYP4F11

2.10e-03154704GO:0020037
GeneOntologyMolecularFunctionneurotransmitter transmembrane transporter activity

SLC6A16 SLC29A4

2.44e-0321702GO:0005326
GeneOntologyMolecularFunctioninterleukin-1 receptor binding

IRAK1 TLR9

2.44e-0321702GO:0005149
GeneOntologyMolecularFunctiontetrapyrrole binding

CYP4F8 PXDNL CYP4F12 CYP4F11

2.64e-03164704GO:0046906
GeneOntologyMolecularFunctioniron ion binding

CYP4F8 CYP4F12 PLOD2 CYP4F11

2.76e-03166704GO:0005506
GeneOntologyMolecularFunctionphosphoric diester hydrolase activity

ENPP6 ENPP3 PLCH2

4.81e-0397703GO:0008081
GeneOntologyMolecularFunctionoxidoreductase activity

CYP4F8 PXDNL DHCR24 KDM3B CYP4F12 COIL PLOD2 CYP4F11

5.24e-03766708GO:0016491
GeneOntologyBiologicalProcessicosanoid catabolic process

CYP4F8 LYPLA2 CYP4F12 CYP4F11

4.18e-0811714GO:1901523
GeneOntologyBiologicalProcessleukotriene B4 catabolic process

CYP4F8 CYP4F12 CYP4F11

7.76e-076713GO:0036101
GeneOntologyBiologicalProcessprostaglandin catabolic process

LYPLA2 CYP4F12 CYP4F11

7.76e-076713GO:1905344
GeneOntologyBiologicalProcessprostanoid catabolic process

LYPLA2 CYP4F12 CYP4F11

7.76e-076713GO:0062232
GeneOntologyBiologicalProcessfatty acid derivative catabolic process

CYP4F8 LYPLA2 CYP4F12 CYP4F11

9.00e-0722714GO:1901569
GeneOntologyBiologicalProcessleukotriene B4 metabolic process

CYP4F8 CYP4F12 CYP4F11

1.35e-067713GO:0036102
GeneOntologyBiologicalProcessleukotriene catabolic process

CYP4F8 CYP4F12 CYP4F11

2.16e-068713GO:0036100
GeneOntologyBiologicalProcesslong-chain fatty acid catabolic process

CYP4F8 CYP4F12 CYP4F11

8.41e-0612713GO:0042758
GeneOntologyBiologicalProcessomega-hydroxylase P450 pathway

CYP4F8 CYP4F12 CYP4F11

1.38e-0514713GO:0097267
GeneOntologyBiologicalProcessmenaquinone catabolic process

CYP4F12 CYP4F11

3.50e-053712GO:0042361
GeneOntologyBiologicalProcessmenaquinone metabolic process

CYP4F12 CYP4F11

6.98e-054712GO:0009233
GeneOntologyBiologicalProcessphylloquinone metabolic process

CYP4F12 CYP4F11

6.98e-054712GO:0042374
GeneOntologyBiologicalProcessphylloquinone catabolic process

CYP4F12 CYP4F11

6.98e-054712GO:0042376
GeneOntologyBiologicalProcessvitamin K catabolic process

CYP4F12 CYP4F11

6.98e-054712GO:0042377
GeneOntologyBiologicalProcesscellular response to erythropoietin

EPOR CD40

1.16e-045712GO:0036018
GeneOntologyBiologicalProcessresponse to erythropoietin

EPOR CD40

1.74e-046712GO:0036017
GeneOntologyBiologicalProcessfatty acid derivative metabolic process

CYP4F8 LYPLA2 CYP4F12 CYP4F11

1.84e-0482714GO:1901568
GeneOntologyBiologicalProcessleukotriene metabolic process

CYP4F8 CYP4F12 CYP4F11

3.79e-0441713GO:0006691
DomainE-NPP

ENPP6 ENPP3

2.96e-047712IPR024873
DomainNotch_dom

PAPPA2 NOTCH4

2.96e-047712IPR000800
DomainNotch

PAPPA2 NOTCH4

2.96e-047712PF00066
DomainNL

PAPPA2 NOTCH4

2.96e-047712SM00004
DomainARM-type_fold

PI4KA DOCK9 ARMC5 UBR4 TMCO6 TAF6 NCDN

3.00e-04339717IPR016024
DomainPhosphodiest

ENPP6 ENPP3

6.29e-0410712PF01663
DomainPhosphodiest/P_Trfase

ENPP6 ENPP3

6.29e-0410712IPR002591
DomainCyt_P450_E_grp-I

CYP4F8 CYP4F12 CYP4F11

6.66e-0445713IPR002401
DomainCyt_P450_CS

CYP4F8 CYP4F12 CYP4F11

1.08e-0353713IPR017972
DomainCYTOCHROME_P450

CYP4F8 CYP4F12 CYP4F11

1.33e-0357713PS00086
Domain-

CYP4F8 CYP4F12 CYP4F11

1.40e-03587131.10.630.10
Domainp450

CYP4F8 CYP4F12 CYP4F11

1.40e-0358713PF00067
DomainCyt_P450

CYP4F8 CYP4F12 CYP4F11

1.54e-0360713IPR001128
DomainLeu-rich_rpt

MXRA5 NOD1 PXDNL PKD1 TLR9

3.70e-03271715IPR001611
DomainLRR_8

MXRA5 PXDNL PKD1 TLR9

4.09e-03171714PF13855
PathwayREACTOME_EICOSANOIDS

CYP4F8 CYP4F12 CYP4F11

1.02e-0512523M27129
PathwayREACTOME_EICOSANOIDS

CYP4F8 CYP4F12 CYP4F11

1.02e-0512523MM14845
PathwayWP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES

CYP4F8 CYP4F12 CYP4F11

1.67e-0514523MM15842
PathwayREACTOME_FATTY_ACIDS

CYP4F8 CYP4F12 CYP4F11

2.09e-0515523M27126
PathwayWP_TRYPTOPHAN_METABOLISM

CYP4F8 DHCR24 CYP4F12 CYP4F11

2.84e-0548524MM15902
PathwayREACTOME_MISCELLANEOUS_SUBSTRATES

CYP4F8 CYP4F12 CYP4F11

3.71e-0518523MM14843
PathwayREACTOME_FATTY_ACIDS

CYP4F8 CYP4F12 CYP4F11

3.71e-0518523MM14841
PathwayREACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX

CYP4F8 CYP4F12 CYP4F11

1.03e-0425523MM14858
PathwayWP_EICOSANOID_METABOLISM_VIA_CYCLOOXYGENASES_COX

CYP4F8 CYP4F12 CYP4F11

2.39e-0433523MM15918
PathwayWP_EICOSANOID_METABOLISM_VIA_LIPOXYGENASES_LOX

CYP4F8 CYP4F12 CYP4F11

2.39e-0433523MM15963
PathwayREACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE

CYP4F12 CYP4F11

7.19e-0411522MM14863
Pubmed

Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism.

CYP4F8 CYP4F12 CYP4F11

4.00e-08476322665481
Pubmed

Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14.

CYP4F8 CYP4F12 CYP4F11

4.00e-08476311185557
Pubmed

Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism.

CYP4F8 CYP4F12 CYP4F11

1.00e-07576322969154
Pubmed

Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation.

CYP4F8 CYP4F12 CYP4F11

1.00e-07576321466787
Pubmed

The cytochrome P450 4 (CYP4) family.

CYP4F8 CYP4F12 CYP4F11

2.00e-0767639068972
Pubmed

Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice.

CYP4F8 CYP4F12 CYP4F11

3.49e-07776322160543
Pubmed

TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.

CYP4F8 CYP4F12 TAF6 CYP4F11

3.20e-064676425209997
Pubmed

Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8.

CYP4F8 CYP4F12

4.71e-06276216112640
Pubmed

Toll-like receptors and CD40 modulate each other's expression affecting Leishmania major infection.

CD40 TLR9

4.71e-06276224387292
Pubmed

Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulation.

CD40 TLR9

4.71e-06276219906293
Pubmed

Deletion of Dicer in late erythroid cells results in impaired stress erythropoiesis in mice.

EPOR DICER1

4.71e-06276224971698
Pubmed

DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia.

EPOR TLR9

4.71e-06276234669439
Pubmed

Activation of APCs through CD40 or Toll-like receptor 9 overcomes tolerance and precipitates autoimmune disease.

CD40 TLR9

4.71e-06276212193753
Pubmed

Toll-like receptor 9, transmembrane activator and calcium-modulating cyclophilin ligand interactor, and CD40 synergize in causing B-cell activation.

CD40 TLR9

1.41e-05376221741080
Pubmed

CD40-dependent and -independent activation of human tonsil B cells by CpG oligodeoxynucleotides.

CD40 TLR9

1.41e-05376212778475
Pubmed

Nod1-mediated lipolysis promotes diacylglycerol accumulation and successive inflammation via PKCδ-IRAK axis in adipocytes.

NOD1 IRAK1

1.41e-05376230391544
Pubmed

3β-hydroxysteroid-Δ24 reductase dampens anti-viral innate immune responses by targeting K27 ubiquitination of MAVS and STING.

MAVS DHCR24

1.41e-05376238032198
Pubmed

Innate Immune Nod1/RIP2 Signaling Is Essential for Cardiac Hypertrophy but Requires Mitochondrial Antiviral Signaling Protein for Signal Transductions and Energy Balance.

NOD1 MAVS

1.41e-05376233070627
Pubmed

Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria.

CYP4F8 CYP4F12 TAF6 CYP4F11

2.40e-057676422323595
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MAN2B1 SZT2 SGSM2 PI4KA DOCK9 UBR4 PKD1 KDM3B IRAK1 TMCO6 MARVELD3

2.75e-051105761135748872
Pubmed

Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein.

MAVS TLR9

2.82e-05476220042593
Pubmed

Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.

CYP4F12 CYP4F11

2.82e-05476218065749
Pubmed

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction.

IRAK1 TLR9

2.82e-05476215767370
Pubmed

Toll-like Receptor 9 Induced Dendritic Cell Activation Promotes Anti-Myeloperoxidase Autoimmunity and Glomerulonephritis.

CD40 TLR9

2.82e-05476236674855
Pubmed

Red blood cell β-adrenergic receptors contribute to diet-induced energy expenditure by increasing O2 supply.

EPOR ADRB3

4.69e-05576228724789
Pubmed

Protein tyrosine phosphatase 1B is involved in efficient type I interferon secretion upon viral infection.

MAVS TLR9

4.69e-05576232265274
Pubmed

Toll-like receptor (TLR) and nucleosome-binding oligomerization domain (NOD) gene polymorphisms and endometrial cancer risk.

NOD1 TLR9

4.69e-05576220646321
Pubmed

Contribution of phagocytosis and intracellular sensing for cytokine production by Staphylococcus aureus-activated macrophages.

NOD1 TLR9

4.69e-05576217118979
Pubmed

Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes.

MAVS TLR9

4.69e-05576220424013
Pubmed

Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination.

MAVS TLR9

4.69e-05576217878370
Pubmed

MicroRNAs regulate renal tubule maturation through modulation of Pkd1.

PKD1 DICER1

4.69e-05576223138483
Pubmed

The Role of REC8 in the Innate Immune Response to Viral Infection.

REC8 MAVS

7.03e-05676235107381
Pubmed

Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals.

CD40 TLR9

7.03e-05676217114424
Pubmed

TLR2 signaling depletes IRAK1 and inhibits induction of type I IFN by TLR7/9.

IRAK1 TLR9

7.03e-05676222227568
Pubmed

Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis.

NOD1 TLR9

7.03e-05676222902233
Pubmed

Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway.

CD40 TLR9

7.03e-05676218322216
Pubmed

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk.

CD40 IRAK1

7.03e-05676221441935
Pubmed

Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.

NOD1 IRAK1 TLR9

8.01e-053876319264973
Pubmed

STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.

MAVS TLR9

9.83e-05776225517615
Pubmed

SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling.

IRAK1 TLR9

9.83e-05776212925853
Pubmed

Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development.

NOD1 TLR9

9.83e-05776219933833
Pubmed

Functional expression of pattern recognition receptors in tissues of the human female reproductive tract.

NOD1 TLR9

9.83e-05776219406482
Pubmed

DAMP-Inducing Adjuvant and PAMP Adjuvants Parallelly Enhance Protective Type-2 and Type-1 Immune Responses to Influenza Split Vaccination.

MAVS TLR9

9.83e-05776230515151
Pubmed

Addendum: defective Dock2 expression in a subset of ASC-deficient mouse lines.

NOD1 MAVS

9.83e-05776222905357
Pubmed

Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.

CYP4F8 CYP4F12 CYP4F11

1.25e-044476312745259
Pubmed

Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.

IRAK1 TLR9

1.31e-04876212724322
Pubmed

T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation.

CD40 IRAK1

1.31e-04876224706909
Pubmed

An innate antiviral pathway acting before interferons at epithelial surfaces.

MAVS TLR9

1.31e-04876226595890
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SZT2 PLCH2 DHCR24 DLGAP5 KDM3B NFASC DICER1

1.60e-0452976714621295
Pubmed

Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.

IRAK1 TLR9

1.68e-04976221435586
Pubmed

Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells.

IRAK1 TLR9

1.68e-04976220200270
Pubmed

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.

MAVS TLR9

1.68e-04976218256672
Pubmed

Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.

UBR4 DDB2

1.68e-04976217855541
Pubmed

Downregulation of the Na/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome.

NOD1 TLR9

2.10e-041076222323544
Pubmed

Targeted inactivation of a developmentally regulated neural plectin isoform (plectin 1c) in mice leads to reduced motor nerve conduction velocity.

PARP10 NFASC

2.10e-041076219625254
Pubmed

Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells.

TAS1R3 PKD1

2.10e-041076216805797
Pubmed

Interplay between cell-adhesion molecules governs synaptic wiring of cone photoreceptors.

CACNA2D4 RGS11

2.10e-041076232879010
Pubmed

Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner.

MAVS TLR9

2.10e-041076219474102
Pubmed

The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88.

CD40 IRAK1

2.10e-041076220676093
Pubmed

CpG DNA prevents liver injury and shock-mediated death by modulating expression of interleukin-1 receptor-associated kinases.

IRAK1 TLR9

2.10e-041076218378686
Pubmed

Inducible CYP4F12 enhances Hepatitis C virus infection via association with viral nonstructural protein 5B.

CYP4F12 MRPS22

2.10e-041076226845356
Pubmed

Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

SZT2 PLCH2 UBR4

2.56e-04567639455484
Pubmed

The Auxiliary Calcium Channel Subunit α2δ4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors.

CACNA2D4 RGS11

2.56e-041176228262416
Pubmed

DNA released from dying host cells mediates aluminum adjuvant activity.

MAVS TLR9

2.56e-041176221765404
Pubmed

Persistence of Integrase-Deficient Lentiviral Vectors Correlates with the Induction of STING-Independent CD8+ T Cell Responses.

MAVS TLR9

2.56e-041176230699352
Pubmed

Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway.

MAVS TLR9

3.07e-041276224743339
Pubmed

Toll-like receptor 7 mediates early innate immune responses to malaria.

MAVS TLR9

3.07e-041276224042114
Pubmed

HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.

UBR4 DDB2

3.07e-041276217360488
Pubmed

RNA is an Adjuvanticity Mediator for the Lipid-Based Mucosal Adjuvant, Endocine.

MAVS TLR9

3.62e-041376227374884
Pubmed

Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins.

IRAK1 TLR9

3.62e-041376230108181
Pubmed

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP.

NOD1 MAVS

3.62e-041376219652017
Pubmed

CD40 Mediates Maturation of Thymic Dendritic Cells Driven by Self-Reactive CD4+ Thymocytes and Supports Development of Natural Regulatory T Cells.

MAVS CD40

3.62e-041376229321275
Pubmed

The DNA sequence and biological annotation of human chromosome 1.

PAPPA2 GPR161 SZT2 TAS1R3 LYPLA2 ERMAP NFASC MDS2 NUDT17

4.11e-04103176916710414
Pubmed

E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKC{zeta}.

IRAK1 TLR9

4.22e-041476221911421
Pubmed

Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.

MAVS TLR9

4.22e-041476221820332
Pubmed

Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection.

MAVS TLR9

4.22e-041476226682986
Pubmed

Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling.

IRAK1 TLR9

4.22e-041476214625308
Pubmed

Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients.

NOD1 TLR9

4.22e-041476220595247
Pubmed

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.

CYP4F8 CYP4F12 CYP4F11

4.94e-047076315128046
Pubmed

Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome.

NOD1 TLR9

5.54e-041676223630357
Pubmed

Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality.

MAVS TLR9

5.54e-041676227793594
Pubmed

A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling.

IRAK1 TLR9

5.54e-041676216024789
Pubmed

MD-2: the Toll 'gatekeeper' in endotoxin signalling.

NOD1 IRAK1 TLR9

5.81e-047476315276183
Pubmed

Cutting Edge: TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells.

MAVS TLR9

6.27e-041776219299691
Pubmed

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.

MAVS DICER1

7.05e-041876222541070
Pubmed

Toll-like receptor signaling pathway variants and prostate cancer mortality.

IRAK1 TLR9

7.87e-041976219505919
Pubmed

Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88.

MAVS TLR9

7.87e-041976217942529
Pubmed

TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.

MAVS TLR9

7.87e-041976228400473
Pubmed

The sequence and analysis of duplication-rich human chromosome 16.

NPIPB11 RGS11 MARVELD3

1.03e-039076315616553
Pubmed

Klf2 is an essential regulator of vascular hemodynamic forces in vivo.

EPOR NOTCH4

1.06e-032276217141159
Pubmed

Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia.

CD40 TLR9

1.16e-032376219047410
Pubmed

Loss of function of the maternal membrane oestrogen receptor ERα alters expansion of trophoblast cells and impacts mouse fertility.

PCDH12 NOTCH4

1.16e-032376236239412
Pubmed

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

NOD1 MAVS CD40

1.17e-039476312761501
Pubmed

Expression of Fas, FasL, caspase-8 and other factors of the extrinsic apoptotic pathway during the onset of interdigital tissue elimination.

NOD1 CD40

1.26e-032476227709293
Pubmed

A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication.

UBR4 PKD1 RGS11 DICER1

1.35e-0321876419460752
Pubmed

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.

GPR161 PKD1

1.37e-032576228154160
Pubmed

Increased dosage of the imprinted Ascl2 gene restrains two key endocrine lineages of the mouse Placenta.

PCSK6 PCDH12

1.48e-032676227542691
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

DOCK9 KDM3B NFASC DICER1

1.52e-0322576412168954
Pubmed

Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

DOCK9 KDM3B TNS2

1.56e-0310476310470851
Pubmed

Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.

DHCR24 CYP4F11

1.72e-032876220689807
InteractionC1QTNF9B interactions

COL18A1 INHBE PCSK6 IRAK1 PLOD2

9.07e-0751705int:C1QTNF9B
Cytoband19p13.1

CYP4F8 CYP4F12 CYP4F11

7.15e-054876319p13.1
CytobandEnsembl 112 genes in cytogenetic band chr1p36

MIIP TAS1R3 LYPLA2 PLCH2 UBR4 MDS2

9.45e-04681766chr1p36
CytobandEnsembl 112 genes in cytogenetic band chr5q31

KDM3B TMCO6 DELE1 PCDH12

1.55e-03298764chr5q31
Cytoband5q31.3

TMCO6 DELE1

1.64e-03367625q31.3
GeneFamilyCytochrome P450 family 4

CYP4F8 CYP4F12 CYP4F11

1.41e-04365131003
CoexpressionMANALO_HYPOXIA_UP

EPOR COL18A1 INHBE NFASC PLOD2 CYP4F11 NOTCH4

2.24e-06205767M259
CoexpressionDESCARTES_ORGANOGENESIS_ENDOTHELIAL_CELLS

COL18A1 ENPP3 DOCK9 CD40 ARHGEF3 PCDH12 NOTCH4

1.42e-05272767MM3634
CoexpressionSAENZ_DETOX_PATHWAY_AND_CARCINOGENESIS_DN

CYP4F8 CYP4F12 CYP4F11

2.58e-0520763MM1104
ToppCell5'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE6 DYTN CD40 MDS2 PCDH12 NOTCH4

6.54e-07180766af7c4b9f1a0ddd894085cf93c29a6d253a7d077c
ToppCell5'-GW_trimst-1-SmallIntestine-Endothelial|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE6 DYTN CD40 MDS2 PCDH12 NOTCH4

6.54e-07180766e35e9159f5cd9ec905b3b6e27d938158aeb9c51c
ToppCell5'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNASE6 DYTN CD40 MDS2 PCDH12 NOTCH4

6.75e-071817667d7d1edeae4e0ebe40b324d1231cd26e27ba9d42
ToppCell10x3'2.3-week_17-19-Endothelial-stroma-proliferating_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

COL18A1 MXRA5 DOCK9 TNS2 PCDH12 NOTCH4

7.92e-07186766a844d4f79e0ad5d6c60a4488ffd8f4f21b7eed04
ToppCellPCW_05-06-Endothelial-Endothelial_immature-endo_immature4_(5)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

DOCK9 PCSK6 CD40 ARHGEF3 PCDH12 NOTCH4

8.43e-07188766b9c5d573fc5ab0f7f38c55d006f9576634b05462
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CACNA2D4 MAN2B1 SGSM2 IRAK1 DELE1 PRSS36

1.21e-0620076688d713dfc792e7609bf7ecfb28f87cb748088570
ToppCellGlobus_pallidus|World / BrainAtlas - Mouse McCarroll V32

MIIP SZT2 PKD1 ERMAP IRAK1

2.51e-0612676544b63f945d5bedf1a2ca1810e7e100276ea9dd89
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PAPPA2 MXRA5 HGSNAT NFASC RGS11

1.39e-05179765a1ea8daa0fe8900f5a04b555c77fe8ebdaa3908d
ToppCellPCW_05-06-Endothelial-Endothelial_mature-lymphatic|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

DOCK9 PCSK6 CD40 PCDH12 NOTCH4

1.67e-0518676586b218a400f9c64f92b050f00b49f09647b17437
ToppCellPCW_05-06-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

DOCK9 PCSK6 CD40 PCDH12 NOTCH4

1.67e-05186765f51c76b1c3c6c49e0ebc9a913d8413e0b6a04d80
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK9 CD40 SIDT1 PCDH12 NOTCH4

1.71e-0518776529b2e2be26a9d72b154760e47acf61cfe2f45fa7
ToppCell10x5'v1-week_14-16-Myeloid_DC-DC-pDC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PARP10 RNASE6 SIDT1 TLR9 NUDT17

1.71e-05187765bf64a6ef5062ec9a0f7095e8c97ce66bfc3bf179
ToppCellPCW_05-06-Endothelial-Endothelial_immature-endo_immature_arterial1_(12)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

DOCK9 PCSK6 CD40 PCDH12 NOTCH4

1.75e-05188765b294d6658e79328bd6fa33223e8c70117ba9789b
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature-endo_bronchial_(8)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK9 PCSK6 CD40 PCDH12 NOTCH4

1.80e-051897654bc3826e0515b3cf2e2ef72a7b2cf9c32ade1812
ToppCellCOVID-19_Moderate-pDC|World / disease group, cell group and cell class

PARP10 RNASE6 SIDT1 NUDT17 NOTCH4

1.89e-0519176593adfbc0b22f6006d6d5ad67a99e33cbe9e1dfe9
ToppCellPCW_05-06-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

DOCK9 CD40 SIDT1 PCDH12 NOTCH4

1.89e-05191765e3fc5c92491b6e334abffbf085c00a0b5fa1aed2
ToppCellPCW_05-06-Endothelial-Endothelial_immature-endo_immature2_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

DOCK9 PCSK6 CD40 PCDH12 NOTCH4

1.94e-05192765f68e6cbde87678122da1b5c0061904cfb7d04bf5
ToppCellPCW_07-8.5-Endothelial-Endothelial_cycling-endo_proliferating2_(14)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK9 DLGAP5 CD40 PCDH12 NOTCH4

1.94e-05192765ac3d87aa301d30515c369bd7fc16f33b82173a85
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK9 PCSK6 ARHGEF3 PCDH12 NOTCH4

1.99e-05193765e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCellPCW_05-06-Endothelial-Endothelial_immature-endo_immature1_(0)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

PCSK6 CD40 ARHGEF3 PCDH12 NOTCH4

1.99e-051937652661ad9107ed9231e4afea4442a79051139a31df
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature-endo_immature_arterial1_(12)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK9 PCSK6 CD40 PCDH12 NOTCH4

1.99e-05193765d338a7c0585b69947c37f44aa0381619493e31ea
ToppCell10x3'2.3-week_14-16-Myeloid_DC-DC-pDC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PARP10 RNASE6 SIDT1 TLR9 NUDT17

1.99e-051937652c35aadc397e7e365c3daf8017ae1d3bd045f305
ToppCellPCW_05-06-Endothelial-Endothelial_cycling-endo_proliferating3_(3)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

DOCK9 PCSK6 CD40 PCDH12 NOTCH4

1.99e-05193765f7e4a390921780587b9bd084e495e646fa1ec74f
ToppCellPCW_07-8.5-Endothelial-Endothelial_cycling-endo_proliferating3_(3)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK9 PCSK6 CD40 PCDH12 NOTCH4

1.99e-0519376572128ece598070f8e752a0691e024e26ab364989
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature-endo_immature4_(5)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK9 PCSK6 CD40 PCDH12 NOTCH4

1.99e-0519376572d20ee257149b238016b44d183ce3fc24b8f621
ToppCell10x5'v1-week_17-19-Myeloid_DC-DC-pDC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PARP10 RNASE6 SIDT1 TLR9 NUDT17

1.99e-051937652a48e72f3df2ad64e1680fca759be8fd2190771e
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature-endo_immature1_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK9 PCSK6 CD40 PCDH12 NOTCH4

2.04e-051947652e3a64bda7c76fd0c99e93de0215f236e8045d83
ToppCellPCW_13-14-Endothelial-Endothelial_mature-endo_capillary_(2)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DOCK9 CD40 ARHGEF3 PCDH12 NOTCH4

2.04e-051947653c31ac44e8cf4eca3ba7b8bfc05ad3e96a970956
ToppCellPCW_05-06-Endothelial|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

DOCK9 PCSK6 CD40 PCDH12 NOTCH4

2.04e-0519476500291c62795a55a7e63b1db10c139d6a3298e55e
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature-endo_immature2_(1)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK9 PCSK6 CD40 PCDH12 NOTCH4

2.04e-05194765760f98bbcb669e599c389ef7892043eee3a05edf
ToppCellPCW_05-06-Endothelial-Endothelial_immature|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

DOCK9 PCSK6 CD40 PCDH12 NOTCH4

2.04e-051947659bd25ea57f2da27bd200d1a8bf797fec77d172c7
ToppCellPCW_05-06-Endothelial-Endothelial_cycling|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

DOCK9 PCSK6 CD40 PCDH12 NOTCH4

2.04e-05194765eb279e0d922de921343f0ae032a809f837d915b3
ToppCellPCW_07-8.5-Endothelial|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK9 PCSK6 CD40 PCDH12 NOTCH4

2.09e-05195765f2cc94d5e1652203ca38bea57f37d3deec73ef04
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK9 PCSK6 CD40 PCDH12 NOTCH4

2.09e-05195765c7abcb674e4a25a5354c4947fffd0d17bc8c1fab
ToppCellPCW_07-8.5-Endothelial-Endothelial_cycling|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

DOCK9 PCSK6 CD40 PCDH12 NOTCH4

2.09e-05195765804b7c44aaaf8ba77e36f377955df261e92f5ff9
ToppCellPCW_10-12-Endothelial-Endothelial_immature-endo_immature1_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DOCK9 CD40 ARHGEF3 PCDH12 NOTCH4

2.14e-0519676529ed8b1c4cd730db8632fde6eece404f1883a86d
ToppCellPCW_10-12-Endothelial-Endothelial_immature|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DOCK9 CD40 ARHGEF3 PCDH12 NOTCH4

2.14e-05196765c65b8c7ea34a21897c390e6fb42ee8ca41e9c976
ToppCellPCW_10-12-Endothelial-Endothelial_mature|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DOCK9 CD40 ARHGEF3 PCDH12 NOTCH4

2.14e-05196765481d79bdaec069ad2746a28d39eeee8d3edf7305
ToppCellPCW_10-12-Endothelial|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DOCK9 CD40 ARHGEF3 PCDH12 NOTCH4

2.14e-051967652c60dcf9132ee156f25b349e2ac5313709def4f6
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

COL18A1 DOCK9 TNS2 PCDH12 NOTCH4

2.25e-0519876572e8b9cccb7b0a2ea9d415218fff4fa2f09728f4
ToppCellCOVID-19-COVID-19_Severe-Myeloid-pDC|COVID-19_Severe / Disease, condition lineage and cell class

PARP10 RNASE6 SIDT1 NUDT17 NOTCH4

2.25e-05198765033ed362333e1d33f2aeea8da5865d2228d154dc
ToppCellPCW_10-12-Endothelial-Endothelial_cycling-endo_proliferating3_(3)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DOCK9 CD40 ARHGEF3 PCDH12 NOTCH4

2.25e-051987655fe186d46c47ea1ca450cf67e8eb01c2c3f7f83c
ToppCellCOVID-19-COVID-19_Mild-Myeloid-pDC|COVID-19_Mild / Disease, condition lineage and cell class

PARP10 RNASE6 SIDT1 NUDT17 NOTCH4

2.30e-051997659de61e5189d907cc969ac3043d68204f70acc0bf
ToppCellLPS-antiTNF-Myeloid-Monocytes,_Macrophages-Erythroid|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA2D4 PI4KA DHCR24 NOTCH4

1.08e-041447641b9e95e4f6e40042d3cf2f94c067f3a6b19428ea
ToppCellRV-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

COL18A1 NFASC MARVELD3 LINC00596

1.62e-0416076429c9b4770d0e73d59cffc7937b179484c76b6dcc
ToppCellPND07-Endothelial-Endothelial_lymphatic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL18A1 ENPP3 DOCK9 PCSK6

1.66e-04161764133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL18A1 ENPP3 DOCK9 PCSK6

1.66e-041617649466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL18A1 ENPP3 DOCK9 PCSK6

1.66e-04161764cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL18A1 ENPP3 DOCK9 PCSK6

1.70e-0416276496c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Ibsp-Inhibitory_Gad1Gad2_Htr3a.Ibsp_(Interneuron,__(candidate_CGE-derived_7))|Hippocampus / BrainAtlas - Mouse McCarroll V32

ENPP3 DYTN ERMAP

1.79e-0464763c13a7edad4d52a955e2c2247139246522d9e4463
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Ibsp-Inhibitory_Gad1Gad2_Htr3a.Ibsp_(Interneuron,__(candidate_CGE-derived_7))-|Hippocampus / BrainAtlas - Mouse McCarroll V32

ENPP3 DYTN ERMAP

1.79e-0464763eefb4573ec4ff8efe602543ccbe555dbef1c4d54
ToppCellHippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)-Ibsp|Hippocampus / BrainAtlas - Mouse McCarroll V32

ENPP3 DYTN ERMAP

1.79e-0464763fcc0f3fa0b462620d031aae810a01fadb7c01202
ToppCell10x5'v1-week_12-13-Myeloid_DC-DC-pDC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

RNASE6 SIDT1 TLR9 NUDT17

1.86e-041667649fa90d9d484563d44738bb2c6eb0775dffc4d549
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RNASE6 MAN2B1 SIDT1 TLR9

1.95e-0416876459b698f58cb206f0f8f0e8ad72b445d14ba24728
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

SGSM2 PCSK6 MARVELD3 ARHGEF3

1.95e-04168764ca94b29c1030484143a77f2df06dad74d2c6136e
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL18A1 ENPP3 PCSK6 PCDH12

2.00e-04169764f077e39e41fffe7672541f5b72b80faaf56c597c
ToppCellfacs-Marrow-KLS-24m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNASE6 GPR152 RGS11 NUDT17

2.00e-04169764d6ad3b637de2935c656aad47ad82d6e8a8bd1227
ToppCellfacs-Marrow-KLS-24m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNASE6 GPR152 RGS11 NUDT17

2.00e-0416976460ef186518d0dc63dbded2a77c65cfe3129df754
ToppCell343B-Myeloid-Dendritic-pDC|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

REC8 PCSK6 SIDT1 NUDT17

2.00e-04169764632aa3ab39ec87bafcefec6cddf71129a054d3b0
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL18A1 ENPP3 PCSK6 PCDH12

2.04e-0417076435e3945d8a540a3e2cec1b559316265aaad023d1
ToppCellPND01-Endothelial-Endothelial_lymphatic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL18A1 ENPP3 PCSK6 PCDH12

2.04e-041707640ea625abaa25bab93b70b7000e8f90d5c0f9a0fb
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL18A1 ENPP3 PCSK6 PCDH12

2.04e-041707640b5ddc7d452db0a389927a367914f7d257703f7e
ToppCellPND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL18A1 ENPP3 DOCK9 PCSK6

2.09e-04171764686f95892c3909973c66c9a27159a070a068f175
ToppCellPND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL18A1 ENPP3 DOCK9 PCSK6

2.09e-04171764f7ba03e7bdb687f93782c936c7b3374cc5b3b77c
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Dendritic-plasmacytoid_dendritic_cell-Plasmacytoid_DCs-Plasmacytoid_DCs_L.1.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RNASE6 MAN2B1 SIDT1 NUDT17

2.09e-041717644fd2c7977c512c51507f055fc74b111c0228ed8b
ToppCellPND14-Endothelial-Endothelial_lymphatic|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL18A1 ENPP3 DOCK9 PCSK6

2.09e-04171764d0ac50071a3854d02113c455fcc940a6ec59bbb9
ToppCellPND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL18A1 ENPP3 DOCK9 PCSK6

2.09e-04171764fbf8e9db00573adcada4b25730e191417b7c9999
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TAS1R3 PCSK6 CD40 NUDT17

2.18e-04173764c63a615998d13b1725b5767f4ad2ec7e2b61db68
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC-arterial_capillary|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK9 TNS2 PCDH12 NOTCH4

2.43e-04178764360d7a987f91d6d721487a921824057ec31a7332
ToppCellDividing_Macrophages-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

MTMR11 RNASE6 DLGAP5 DDB2

2.43e-041787646557688c6790a5bcc3b9aea5b8789cf9506b3c54
ToppCell(01)_Cycling_Basal_(homeostasis)-(1)_24hpi|(01)_Cycling_Basal_(homeostasis) / shred by cell type and Timepoint

COL18A1 EML6 PRSS36

2.44e-04717636aa56b0daaeb5e0ae30619f9c6945c8e42899b27
ToppCelldroplet-Bladder-Unstain-18m-Epithelial-granulocyte-monocyte_progenitor|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

REC8 EPOR DLGAP5 ERMAP

2.49e-04179764804aa3899585fc7e662eff9f6d41f48655f16dd6
ToppCell368C-Endothelial_cells-Endothelial-E|368C / Donor, Lineage, Cell class and subclass (all cells)

DOCK9 PCSK6 PCDH12 NOTCH4

2.54e-041807648ab16a0b9053bffc07b569a4f9e71749f56dde7e
ToppCellPCW_05-06-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CD40 SIDT1 PCDH12 NOTCH4

2.54e-041807645861b44acfb8fe92c281c8355bf19c059b3dcd64
ToppCell368C-Endothelial_cells-Endothelial-E-|368C / Donor, Lineage, Cell class and subclass (all cells)

DOCK9 PCSK6 PCDH12 NOTCH4

2.54e-04180764394cd465b88429b70eebb2957480dffcbc51cfe7
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP6 NFASC PLOD2 SEZ6L

2.59e-041817644e81ec1580e9acb22c32c465eb46f83d1e9e424e
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP6 NFASC PLOD2 SEZ6L

2.59e-04181764ad30c01290fb98adbd0caed301a584761212c977
ToppCellwk_20-22-Hematologic-Myeloid-pDC|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

PARP10 RNASE6 SIDT1 TLR9

2.59e-0418176460607c5ff6d5b1cb416adc034491dca31c41e988
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP6 NFASC PLOD2 SEZ6L

2.59e-041817643a3268a4dff8ffcb79e09f46490e138c96f8d916
ToppCell3'-Adult-LargeIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PAPPA2 EML6 RGS11 SLC29A4

2.70e-0418376449f3ddc1c7c04b4ca837dbd6dad995add82941d6
ToppCelldroplet-Trachea-nan-3m-Endothelial|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP6 DOCK9 PCDH12 NOTCH4

2.76e-04184764fa5c3020e75fdde1363393dea97ebd99f1eae9ff
ToppCelldroplet-Trachea-3m-Endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENPP6 DOCK9 PCDH12 NOTCH4

2.76e-04184764ad520ab6bb776b5303df505b7e1afb22484f18a7
ToppCelldroplet-Trachea-nan-3m-Endothelial-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP6 DOCK9 PCDH12 NOTCH4

2.76e-041847641d63cb75a89c5f3f3b9ebf7fce8cb0fd4a92b645
ToppCelldroplet-Trachea-nan-3m-Endothelial-endothelial_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP6 DOCK9 PCDH12 NOTCH4

2.76e-0418476476caad53d55fff5acca27bf190a6de7b27437d9f
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENPP6 DOCK9 PCDH12 NOTCH4

2.76e-041847641fc1f0a3b4dbb085ebcc3960f67be24a108fe5b9
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENPP6 DOCK9 PCDH12 NOTCH4

2.76e-041847642467207aaea307873ab286f89cfc7668a227a694
ToppCell10x5'-bone_marrow-Myeloid_Dendritic-pDC|bone_marrow / Manually curated celltypes from each tissue

RNASE6 TLR9 NUDT17 NOTCH4

2.76e-041847642817d530863e85dfdcd143b7a3dc5fc58a9cd98b
ToppCelldroplet-Lung-nan-3m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL18A1 ENPP3 PCSK6 EML6

2.82e-041857646a85399cfdb9b89683c874e7f046957f9a601dc2
ToppCellBac-SEP-Myeloid-pDC|Bac-SEP / Disease, Lineage and Cell Type

RNASE6 SIDT1 NUDT17 NOTCH4

2.82e-041857643de50b2042f22b0fb62ff12c76d85cc67649a0bd
ToppCelldroplet-Lung-nan-3m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL18A1 ENPP3 PCSK6 EML6

2.82e-0418576464791056cdbb739136dbef08f4b16e2b5427faad
ToppCellICU-NoSEP-Myeloid-pDC|ICU-NoSEP / Disease, Lineage and Cell Type

RNASE6 SIDT1 NUDT17 NOTCH4

2.82e-041857647564a47df4a4e3af30d40aa0f48bd9d9c82358ae
ToppCellPCW_05-06-Endothelial-Endothelial_mature-endo_bronchial_(8)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

PCSK6 CD40 PCDH12 NOTCH4

2.88e-041867640cc7504297fd0c97ea50e4b3ff58fcedc4c1cfaa
ToppCellMultiple_Sclerosis-Myeloid-pDC|Multiple_Sclerosis / Disease, Lineage and Cell Type

RNASE6 SIDT1 NUDT17 NOTCH4

2.88e-04186764330a4f669adea91ff9f2dff2de2210f5e3401e19
ToppCelldroplet-Liver-Hepatocytes-24m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP6 CCDC9B PCDH12 NOTCH4

2.88e-041867642cae34336f184f971f7c8684cc27c23a4e7369ed
ToppCelldroplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ENPP6 DOCK9 TNS2 NOTCH4

2.88e-041867649c7924875f70420720149287c500b4dfa8d24673
ToppCellmyeloid-Dendritic_cell-Plasmacytoid_dendritic_cell|Dendritic_cell / Lineage, cell class and subclass

PARP10 SIDT1 NUDT17 NOTCH4

2.88e-04186764858134580a09ed8a5eb6d6413d8ca9265904dfc1
ToppCelldroplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP6 CCDC9B PCDH12 NOTCH4

2.88e-0418676490d53c2597a9f3a2b39afba75adfc54f1ca0a4db
ToppCell356C-Endothelial_cells-Endothelial-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

COL18A1 DOCK9 PCDH12 NOTCH4

2.88e-041867642e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell356C-Endothelial_cells-Endothelial-E|356C / Donor, Lineage, Cell class and subclass (all cells)

COL18A1 DOCK9 PCDH12 NOTCH4

2.88e-04186764c3449e54454009973818fc1101933c6f0168258c
ToppCellE16.5-samps-Epithelial-Alveolar_epithelial_precursor-Proliferative_AT2_Progenitor|E16.5-samps / Age Group, Lineage, Cell class and subclass

COL18A1 PCSK6 DLGAP5 MARVELD3

2.94e-04187764e986901f5a1e09cbc9ba37e3c62845ff90ceda95
Diseasesplicing factor 3B subunit 4 measurement

MTMR11 ARHGEF3

6.01e-055732EFO_0803100
Diseaseprocollagen-lysine,2-oxoglutarate 5-dioxygenase 2 measurement

ARHGEF3 PLOD2

6.01e-055732EFO_0802912
Diseasetonsillectomy risk measurement

PARP10 PXDNL CD40 HCP5 NOTCH4

4.71e-04260735EFO_0007924
Diseasesystemic lupus erythematosus (is_implicated_in)

EPOR CD40 TLR9

4.95e-0462733DOID:9074 (is_implicated_in)
Diseaseendoplasmic reticulum resident protein 29 measurement

ARHGEF3 NOTCH4

7.08e-0416732EFO_0020346
Diseaseallergic rhinitis (is_marker_for)

CD40 TLR9

8.02e-0417732DOID:4481 (is_marker_for)
Diseasedermatomyositis (is_marker_for)

CD40 TLR9

8.02e-0417732DOID:10223 (is_marker_for)
Diseaseperinatal necrotizing enterocolitis (biomarker_via_orthology)

CD40 TLR9

8.02e-0417732DOID:8677 (biomarker_via_orthology)
Diseasemucocutaneous lymph node syndrome

ENPP6 CD40 MRPS22

8.97e-0476733EFO_0004246
Diseasesusceptibility to shingles measurement

NFASC HCP5 NOTCH4

1.08e-0381733EFO_0008401
Diseasechronic hepatitis B virus infection

CD40 NOTCH4

1.61e-0324732EFO_0004239

Protein segments in the cluster

PeptideGeneStartEntry
GVHWCNLGSLQPLPP

LINC00596

61

Q86U02
HVGPILVGWLPCLSS

ARHGEF3

196

Q9NR81
LLGNWCGHHLPPPVT

CDCP2

331

Q5VXM1
LLHWLHPCPLSGPLR

CDCP2

416

Q5VXM1
PLRGLSPGAAWPVLH

ARMC5

791

Q96C12
VPPAATLALTGHWPL

ADRB3

91

P13945
LQPPSPRPLECWSLH

C1orf147

6

Q96MC9
HPIPASLWRKAVCLP

DICER1

1041

Q9UPY3
ELLGLWTHCAQPPPK

REC8

361

O95072
HWPHVLPLEPGGCID

RFWD3

626

Q6PCD5
HDPLVSGCLPSNPWI

RGS11

261

O94810
AGWDPCLQAPFHLTP

PCDH12

806

Q9NPG4
VPCHRPSPGALWLQV

MAVS

506

Q7Z434
GCVPLLPWLAPAALR

NCDN

646

Q9UBB6
LKLWLQHLGRTPPPC

NUDT17

286

P0C025
SHWGACPLPPGLLLP

MTMR11

611

A4FU01
VAPAFLPLWLPRGCS

CCDC9B

21

Q6ZUT6
LWLHVLPTLPGTLCL

INHBE

126

P58166
WLLLLALPAACSAPP

PCSK6

51

P29122
LPVCGHLGISRFWLP

COL18A1

341

P39060
DAHCTWLSLPGLPPG

PPM1N

81

Q8N819
PPPATPHCTAFWLLV

COIL

16

P38432
LSHVLCWAPTDPPTG

PI4KA

1606

P42356
SSCPWEPAHPLVLLA

NOD1

301

Q9Y239
PCPDTAPPSSALHWL

KDM3B

1211

Q7LBC6
LLALCPHWYPGHRPV

GPR152

131

Q8TDT2
SASQWDCPLGLIPHP

DDB2

316

Q92466
SWHLTPSCPLDPAPL

IRAK1

601

P51617
PGREPSPGICWHLNL

MDS2

116

Q8NDY4
SPGICWHLNLGLPSL

MDS2

121

Q8NDY4
DPWVPHELLLPSLCD

HCP5

61

Q6MZN7
LLLALVLHPWNPCLG

PLOD2

11

O00469
HLPSVCGERLWVPLP

NPIPB11

876

E5RHQ5
LGPAVWPVCLPRASH

PRSS36

151

Q5K4E3
PPPWVHAAFLLCLLS

NFASC

6

O94856
LPNHRPLTGWFPCVA

PAPPA2

1226

Q9BXP8
LFLLAGWCLPGLPCP

PXDNL

11

A1KZ92
QWEPPLLPHSHSACL

DOCK9

1656

Q9BZ29
VLRAVLSPPCWAPHS

LINC00304

31

Q8N9R0
NCPGWLDVLPFIIPH

ENPP3

796

O14638
LELLVPSPSLPRGCW

DCDC2B

211

A2VCK2
QSEPPILLWLPTCHR

DYTN

201

A2CJ06
SASPPLLLLPVCAWG

CACNA2D4

1116

Q7Z3S7
WLCPFILPSQPGLVH

DHCR24

411

Q15392
WLGPTFPLLILCHPD

CYP4F11

91

Q9HBI6
WLGPITPIINLCHPD

CYP4F8

91

P98187
WLGPIIPFIVLCHPD

CYP4F12

91

Q9HCS2
SNKLPCPLGPLTVWH

DLGAP5

376

Q15398
PWHCPLLLVTEGLLD

MARVELD3

296

Q96A59
LPPSVHLLTLASWGP

MAN2B1

896

O00754
PHPLAGIVALSCWLP

LYPLA2

136

O95372
CLLLAGAAWAPPPNL

EPOR

16

P19235
IWLHSLIGCLPPLFG

GPR161

151

Q8N6U8
WLGLTFLLPVPGCPT

HGSNAT

431

Q68CP4
VWGLAAHPLLPICAT

EML6

1001

Q6ZMW3
APPVWPSHCALALIL

ENPP6

421

Q6UWR7
PLWHPCSSLRQHILP

DELE1

131

Q14154
LPHLPAQLEGTWACP

PKD1

751

P98161
PAESWHLSPLLCVGL

PKD1

4076

P98161
ALPVLPGNAHTLWTP

PARP10

566

Q53GL7
AELLCPLSLWPGTVP

ERMAP

46

Q96PL5
PWHGGLLQPLPCSFE

MRPS22

31

P82650
PLPRVPLDVCLKAHW

TAF6

121

P49848
LSGLPGPCLPDFWLI

SZT2

1906

Q5T011
VLHLALPTSCRPWLP

SZT2

2221

Q5T011
ILGQPSHWNGPLPVC

SEZ6L

916

Q9BYH1
ISPIFGWLWPHLCPV

SLC6A16

606

Q9GZN6
ALPRHCLLGWDIFPP

MIIP

311

Q5JXC2
GPSLPAWHLEPLCSQ

SGSM2

441

O43147
LLVLWGPVCPLHAWP

RNASE6

11

Q93091
PWPVLCSPVAGVILL

NOTCH4

1446

Q99466
LWALLHPGTGAPLCL

TAS1R3

11

Q7RTX0
HLNLKWNCPPVGLSP

TLR9

91

Q9NR96
LPFRPPWGCLSLVGV

PLCH2

1231

O75038
CALPWLLLAASPGHP

SIDT1

11

Q9NXL6
CQRLWPGPLLPALLH

TMCO6

416

Q96DC7
PALRHPAWPCIFSLL

SLC29A4

441

Q7RTT9
CNGLLPVWGPHVPES

UBR4

4916

Q5T4S7
GWPELHAPPLDKLCS

TNS2

196

Q63HR2
WGCLLTAVHPEPPTA

CD40

11

P25942
LLWGHPRVALACPHP

MXRA5

16

Q9NR99