Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	pancreatic polypeptide receptor activity	NPY4R2 NPY4R	2.71e-05	4	43	2	GO:0001602
GeneOntologyMolecularFunction	neuropeptide Y receptor activity	NPY4R2 NPY4R	2.46e-04	11	43	2	GO:0004983
GeneOntologyBiologicalProcess	embryonic retina morphogenesis in camera-type eye	HIPK2 HIPK1	6.33e-05	6	43	2	GO:0060059
GeneOntologyBiologicalProcess	lens induction in camera-type eye	HIPK2 HIPK1	8.86e-05	7	43	2	GO:0060235
Domain	DUF4599	SPATA31A3 SPATA31A5 SPATA31A7	2.29e-06	12	42	3	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A5 SPATA31A7	2.29e-06	12	42	3	IPR027970
Domain	NPY4_rcpt	NPY4R2 NPY4R	4.94e-06	2	42	2	IPR001933
Domain	NPY_rcpt	NPY4R2 NPY4R	1.76e-04	9	42	2	IPR000611
Domain	Mab-21	MAB21L3 ITPRIPL2	3.21e-04	12	42	2	PF03281
Domain	Mab-21	MAB21L3 ITPRIPL2	3.21e-04	12	42	2	SM01265
Domain	Mab-21_dom	MAB21L3 ITPRIPL2	3.21e-04	12	42	2	IPR024810
Domain	uDENN	DENND4A SBF2	4.42e-04	14	42	2	SM00800
Domain	uDENN	DENND4A SBF2	5.09e-04	15	42	2	PF03456
Domain	DENN	DENND4A SBF2	5.81e-04	16	42	2	PF02141
Domain	UDENN	DENND4A SBF2	5.81e-04	16	42	2	PS50946
Domain	DDENN	DENND4A SBF2	5.81e-04	16	42	2	PS50947
Domain	dDENN_dom	DENND4A SBF2	5.81e-04	16	42	2	IPR005112
Domain	uDENN_dom	DENND4A SBF2	5.81e-04	16	42	2	IPR005113
Domain	dDENN	DENND4A SBF2	5.81e-04	16	42	2	PF03455
Domain	DENN	DENND4A SBF2	5.81e-04	16	42	2	SM00799
Domain	DENN	DENND4A SBF2	5.81e-04	16	42	2	PS50211
Domain	DENN_dom	DENND4A SBF2	5.81e-04	16	42	2	IPR001194
Domain	dDENN	DENND4A SBF2	5.81e-04	16	42	2	SM00801
Domain	GPCR_Rhodpsn_7TM	OR11L1 NPY4R2 OR10C1 NPY4R OR10X1 OR6P1 CNR2	6.69e-04	670	42	7	IPR017452
Domain	7tm_1	OR11L1 NPY4R2 OR10C1 NPY4R OR10X1 OR6P1 CNR2	7.12e-04	677	42	7	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR11L1 NPY4R2 OR10C1 NPY4R OR10X1 OR6P1 CNR2	7.63e-04	685	42	7	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR11L1 NPY4R2 OR10C1 NPY4R OR10X1 OR6P1 CNR2	8.03e-04	691	42	7	PS50262
Domain	GPCR_Rhodpsn	OR11L1 NPY4R2 OR10C1 NPY4R OR10X1 OR6P1 CNR2	8.10e-04	692	42	7	IPR000276
Domain	Prot-tyrosine_phosphatase-like	TNS2 PTPRF SBF2	1.43e-03	99	42	3	IPR029021
Domain	Olfact_rcpt	OR11L1 OR10C1 OR10X1 OR6P1	1.15e-02	393	42	4	IPR000725
Pathway	WP_MIR222_IN_EXERCISEINDUCED_CARDIAC_GROWTH	HIPK2 HIPK1	4.36e-05	5	30	2	MM15988
Pathway	REACTOME_PHYSIOLOGICAL_FACTORS	HIPK2 HIPK1	3.92e-04	14	30	2	M27459
Pathway	REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION	HIPK2 HIPK1	4.52e-04	15	30	2	M603
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A1 SPATA31A3 SPATA31A5 SPATA31A7	3.03e-11	6	43	4	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A1 SPATA31A3 SPATA31A5 SPATA31A7	3.03e-11	6	43	4	25930072
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A1 SPATA31A3 SPATA31A5 SPATA31A7	2.11e-08	24	43	4	32212159
Pubmed	Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation.	DUOX1 DUOXA1	1.49e-06	2	43	2	32929281
Pubmed	Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation.	HIPK2 HIPK1	1.49e-06	2	43	2	20231426
Pubmed	Structures of human dual oxidase 1 complex in low-calcium and high-calcium states.	DUOX1 DUOXA1	1.49e-06	2	43	2	33420071
Pubmed	ASH2L Aggravates Fibrosis and Inflammation through HIPK2 in High Glucose-Induced Glomerular Mesangial Cells.	HIPK2 ASH2L	1.49e-06	2	43	2	36553510
Pubmed	Dual oxidase regulates neutrophil recruitment in allergic airways.	DUOX1 DUOXA1	4.48e-06	3	43	2	23770197
Pubmed	Epidermal growth factor-induced hydrogen peroxide production is mediated by dual oxidase 1.	DUOX1 DUOXA1	4.48e-06	3	43	2	27262981
Pubmed	Update on the Regulation of HIPK1, HIPK2 and HIPK3 Protein Kinases by microRNAs.	HIPK2 HIPK1	4.48e-06	3	43	2	29793420
Pubmed	Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.	NPY4R2 NPY4R	4.48e-06	3	43	2	8643460
Pubmed	CircASH2L facilitates tumor-like biologic behaviours and inflammation of fibroblast-like synoviocytes via miR-129-5p/HIPK2 axis in rheumatoid arthritis.	HIPK2 ASH2L	8.94e-06	4	43	2	33964939
Pubmed	Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.	HIPK2 HIPK1	8.94e-06	4	43	2	34785661
Pubmed	The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA.	DUOX1 DUOXA1	8.94e-06	4	43	2	22814254
Pubmed	Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.	NPY4R2 NPY4R	8.94e-06	4	43	2	7592911
Pubmed	Stabilization of HIPK2 by escape from proteasomal degradation mediated by the E3 ubiquitin ligase Siah1.	HIPK2 HIPK1	8.94e-06	4	43	2	19250734
Pubmed	Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).	HIPK2 HIPK1	8.94e-06	4	43	2	25630557
Pubmed	Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.	DUOX1 DUOXA1	8.94e-06	4	43	2	19339556
Pubmed	A probabilistic classifier for olfactory receptor pseudogenes.	OR10C1 OR10X1 OR6P1	1.12e-05	35	43	3	16939646
Pubmed	Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.	NPY4R2 NPY4R	1.49e-05	5	43	2	7493937
Pubmed	Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.	HIPK2 HIPK1	2.23e-05	6	43	2	12529400
Pubmed	Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis.	HIPK2 HIPK1	2.23e-05	6	43	2	20579985
Pubmed	Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation.	HIPK2 HIPK1	2.23e-05	6	43	2	16917507
Pubmed	Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors.	HIPK2 HIPK1	2.23e-05	6	43	2	9748262
Pubmed	Mammalian numb-interacting protein 1/dual oxidase maturation factor 1 directs neuronal fate in stem cells.	DUOX1 DUOXA1	5.35e-05	9	43	2	20233719
Pubmed	Role of the C-terminal binding protein PXDLS motif binding cleft in protein interactions and transcriptional repression.	HIPK2 HIPK1	5.35e-05	9	43	2	16940173
Pubmed	Functional proteomics mapping of a human signaling pathway.	PIGQ ZFYVE9 PTPRF ASH2L HIPK1 PPP1R15B	8.39e-05	591	43	6	15231748
Pubmed	Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals.	HIPK2 HIPK1	9.78e-05	12	43	2	16537918
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	DENND4A GBF1 ZFYVE9 TRPM7 PPP1R15B	3.83e-04	504	43	5	34432599
Pubmed	Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism.	HIPK2 HIPK1	5.93e-04	29	43	2	23565059
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR11L1 OR10C1 OR10X1 OR6P1	8.20e-04	340	43	4	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR11L1 OR10C1 OR10X1 OR6P1	8.20e-04	340	43	4	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR11L1 OR10C1 OR10X1 OR6P1	8.47e-04	343	43	4	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR11L1 OR10C1 OR10X1 OR6P1	8.75e-04	346	43	4	14611657
Pubmed	Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.	DENND4A SBF2	9.67e-04	37	43	2	20937701
Pubmed	Personal receptor repertoires: olfaction as a model.	OR10C1 OR10X1	1.02e-03	38	43	2	22908908
Pubmed	Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.	PTPRF HIPK1	1.02e-03	38	43	2	28680062
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A5 SPATA31A7	2.39e-05	8	43	2	chr9q12
Cytoband	9p13.1	SPATA31A1 SPATA31A3	2.33e-04	24	43	2	9p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr15q21	DUOX1 DUOXA1 TRPM7	6.21e-04	177	43	3	chr15q21
Cytoband	1q23.1	OR10X1 OR6P1	8.64e-04	46	43	2	1q23.1
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND4A SBF2	6.31e-04	25	27	2	504
GeneFamily	Olfactory receptors, family 10	OR10C1 OR10X1	4.34e-03	66	27	2	157
Disease	Immune System Diseases	TRPM7 CNR2	3.75e-05	7	40	2	C0021053
Disease	Gastrointestinal Stromal Sarcoma	HIPK2 HIPK1	1.86e-03	47	40	2	C3179349
Disease	Gastrointestinal Stromal Tumors	HIPK2 HIPK1	2.11e-03	50	40	2	C0238198
Disease	mean reticulocyte volume	PIGQ OR11L1 PTPRF OR10X1 OR6P1	4.32e-03	799	40	5	EFO_0010701
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	GBF1 SLC2A2 SBF2	6.19e-03	276	40	3	EFO_0004612, EFO_0020943
Disease	household income	GBF1 PTPRF TRPM7	8.07e-03	304	40	3	EFO_0009695
Disease	Liver Cirrhosis	TRPM7 CNR2	8.63e-03	103	40	2	C0023890
Disease	Fibrosis, Liver	TRPM7 CNR2	8.96e-03	105	40	2	C0239946

Protein segments in the cluster

Peptide	Gene	Start	Entry
PVYKPYLTLCAGRRI	EGFL8	56	Q99944
KPIPGDLYRACLYER	ASH2L	366	Q9UBL3
LTAIDRYLCLRYPPS	CNR2	126	P34972
QIYLCYRRGRDKPPL	DENND4A	86	Q7Z401
LLPLFYPTLCEPIRY	PCDHGB7	21	Q9Y5F8
DRCARYPKLYLDGPF	DUOX1	1356	Q9NRD9
YDRFLAICNPLRYPL	OR10X1	136	Q8NGY0
YYRAPEIILGLPFCE	HIPK2	366	Q9H2X6
PLGFILVCYARIYRR	NPY4R	226	P50391
RLYYPEIFRACLGLI	SBF2	126	Q86WG5
RYYRAPEIILGLPFC	HIPK1	356	Q86Z02
YRVLPRIGYLCPKDL	SPINK5	996	Q9NQ38
LLGFCLPLYLICYRR	SLC43A2	526	Q8N370
LFFCPESPRYLYIKL	SLC2A2	236	P11168
YLPIYFGNVCLRFLP	MED23	951	Q9ULK4
DRYLAICSPLRYPFL	OR11L1	121	Q8NGX0
EPRGPFYFCRLLLDD	RALGAPA2	1596	Q2PPJ7
RYYTLQGTRLPCPLR	MAB21L3	91	Q8N8X9
DRYLAICGPLLYPSL	OR6P1	121	Q8NGX9
FLYGFRILPLYRCSR	GJA8	171	P48165
LVPYGLPCIRELFRF	GBF1	396	Q92538
PCRLYRARAGYLTTP	KIRREL2	651	Q6UWL6
LPHYLGALERLDYPR	CERCAM	46	Q5T4B2
FTPRSPCGLYRQYRL	DUOXA1	161	Q1HG43
LPGELLGYRLQYCRA	PTPRF	846	P10586
RYAAICEPLRYPLLL	OR10C1	121	Q96KK4
LPKYPLGRQIRELYC	ORC3	426	Q9UBD5
LLRAYGGPRYLARCP	ITPRIPL2	506	Q3MIP1
FNYYSPRRRPKLLDC	RNF152	16	Q8N8N0
LYRDPALLGLRCPLY	PLEKHG4	1116	Q58EX7
LYSLGLRLCRPYRLA	PIGQ	496	Q9BRB3
LLLPYLSYFRCDDPP	SPATA31A7	41	Q8IWB4
IFGCKYRYLPERPHL	RNF217	471	Q8TC41
YLLNPSYLDCFPRLE	PPP1R15B	221	Q5SWA1
LLLPYLSYFRCDDPP	SPATA31A3	41	Q5VYP0
LLLPYLSYFRCDDPP	SPATA31A1	41	Q5TZJ5
LLLPYLSYFRCDDPP	SPATA31A5	41	Q5VU36
PLGFILVCYARIYRR	NPY4R2	226	P0DQD5
PLQYYLLGDRPCRAR	TSPY26P	321	Q9H489
IPYSPRFLEVFLLYC	TRPM7	1696	Q96QT4
RRLCRSLSEGLYPYP	TNS2	641	Q63HR2
LRLGAEYRLYPCPLF	ZFYVE9	1076	O95405
EYRLYPCPLFSVRFR	ZFYVE9	1081	O95405
YYRPDLNFPCSLPRR	UBASH3A	426	P57075