Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	pyrophosphatase activity	ATP7A ABCF3 MYO9B ABCA7 PRUNE1 GSPT2 ATP8A1 DDX24 GNL1 PIF1 KIFC1 DHX16 EFL1 FIGNL2 NVL ABCC11 RNF213 IDE NUDT13 OPA1 KIF20B MMAA MACF1 IRGC SNRNP200 MMUT	2.16e-07	839	196	26	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	ATP7A ABCF3 MYO9B ABCA7 PRUNE1 GSPT2 ATP8A1 DDX24 GNL1 PIF1 KIFC1 DHX16 EFL1 FIGNL2 NVL ABCC11 RNF213 IDE NUDT13 OPA1 KIF20B MMAA MACF1 IRGC SNRNP200 MMUT	2.21e-07	840	196	26	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	ATP7A ABCF3 MYO9B ABCA7 PRUNE1 GSPT2 ATP8A1 DDX24 GNL1 PIF1 KIFC1 DHX16 EFL1 FIGNL2 NVL ABCC11 RNF213 IDE NUDT13 OPA1 KIF20B MMAA MACF1 IRGC SNRNP200 MMUT	2.21e-07	840	196	26	GO:0016818
GeneOntologyMolecularFunction	ATP hydrolysis activity	ATP7A ABCF3 MYO9B ABCA7 ATP8A1 DDX24 PIF1 KIFC1 DHX16 FIGNL2 NVL ABCC11 RNF213 IDE KIF20B MMAA MACF1 SNRNP200	3.83e-07	441	196	18	GO:0016887
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	ATP7A ABCF3 MYO9B ABCA7 GSPT2 ATP8A1 DDX24 GNL1 PIF1 KIFC1 DHX16 EFL1 FIGNL2 NVL ABCC11 RNF213 IDE OPA1 KIF20B MMAA MACF1 IRGC SNRNP200 MMUT	6.67e-07	775	196	24	GO:0017111
GeneOntologyMolecularFunction	ATP-dependent activity	ATP7A ABCF3 MYO5A MYO9B ABCA7 ATP8A1 DDX24 PIF1 KIFC1 DHX16 DNHD1 FIGNL2 NVL ABCC11 RNF213 IDE KIF20B MMAA MACF1 SNRNP200	2.85e-06	614	196	20	GO:0140657
MousePheno	decreased neocortex size	ARFGEF1 ELP2 HTT	1.19e-05	5	150	3	MP:0020069
Domain	ARM-type_fold	TRPC4AP INTS1 TOGARAM1 PIK3C2A INSC RPTOR NCAPD2 DIAPH3 HECTD1 PKP4 ARFGEF2 ARFGEF1 FHOD3 HEATR5A RIF1 MTOR HTT	1.14e-07	339	196	17	IPR016024
Domain	P-loop_NTPase	ABCF3 MYO5A MYO9B ABCA7 GSPT2 MYO18B DDX24 GNL1 PIF1 KIFC1 DHX16 DNHD1 EFL1 FIGNL2 NVL ABCC11 RNF213 OPA1 KIF20B SBNO2 MMAA PMVK IRGC SNRNP200 HYDIN	3.08e-06	848	196	25	IPR027417
Domain	-	TOGARAM1 INSC RPTOR NCAPD2 HECTD1 PKP4 ARFGEF2 ARFGEF1 HEATR5A RIF1 MTOR HTT	4.13e-06	222	196	12	1.25.10.10
Domain	ARM-like	TOGARAM1 INSC RPTOR NCAPD2 HECTD1 PKP4 ARFGEF2 ARFGEF1 FHOD3 HEATR5A RIF1 MTOR HTT	5.79e-06	270	196	13	IPR011989
Domain	-	ABCF3 ABCA7 GSPT2 DDX24 GNL1 PIF1 DHX16 DNHD1 EFL1 FIGNL2 NVL ABCC11 RNF213 OPA1 SBNO2 MMAA PMVK IRGC SNRNP200 HYDIN	1.18e-04	746	196	20	3.40.50.300
Domain	AAA	ABCF3 ABCA7 FIGNL2 NVL ABCC11 RNF213 MMAA SNRNP200	1.42e-04	144	196	8	SM00382
Domain	AAA+_ATPase	ABCF3 ABCA7 FIGNL2 NVL ABCC11 RNF213 MMAA SNRNP200	1.42e-04	144	196	8	IPR003593
Domain	-	FBXW10B PEX7 DDB1 SEMA5B RPTOR WDR17 FBXW10 WDR7 GNB1L MST1R WDR74 ELP2	2.16e-04	333	196	12	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	FBXW10B PEX7 DDB1 SEMA5B RPTOR WDR17 FBXW10 WDR7 GNB1L MST1R WDR74 ELP2	2.28e-04	335	196	12	IPR015943
Domain	WD40_repeat_dom	FBXW10B ITFG2 PEX7 DDB1 RPTOR WDR17 FBXW10 WDR7 GNB1L WDR74 ELP2	3.13e-04	297	196	11	IPR017986
Domain	HEAT	TOGARAM1 RPTOR NCAPD2 MTOR HTT	3.53e-04	58	196	5	IPR000357
Domain	FH2	DIAPH3 FHOD3 FMN2	4.72e-04	15	196	3	PS51444
Domain	FH2_Formin	DIAPH3 FHOD3 FMN2	4.72e-04	15	196	3	IPR015425
Domain	FH2	DIAPH3 FHOD3 FMN2	4.72e-04	15	196	3	PF02181
Domain	FH2	DIAPH3 FHOD3 FMN2	4.72e-04	15	196	3	SM00498
Domain	DCB_dom	ARFGEF2 ARFGEF1	6.48e-04	4	196	2	IPR032629
Domain	Sec7_C	ARFGEF2 ARFGEF1	6.48e-04	4	196	2	IPR015403
Domain	DUF1981	ARFGEF2 ARFGEF1	6.48e-04	4	196	2	PF09324
Domain	Sec7_N	ARFGEF2 ARFGEF1	6.48e-04	4	196	2	IPR032691
Domain	Sec7_N	ARFGEF2 ARFGEF1	6.48e-04	4	196	2	PF12783
Domain	DCB	ARFGEF2 ARFGEF1	6.48e-04	4	196	2	PF16213
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MYO9B SPEG INTS1 OBSCN APBB3 EXTL3 ANKHD1 ABCA7 MAP3K5 GGT7 PCNX2 JAG2 RPTOR NCAPD2 ZNF398 DENND5A HECTD1 D2HGDH SDHA ZNF628 SLC35B3 MYOM3 ARFGEF2 SBNO2 MST1R ADAMTS7 MTOR KANK3 HTT	1.01e-11	1105	200	29	35748872
Pubmed	Defining the membrane proteome of NK cells.	LPCAT1 ATP7A HK2 ABCF3 MYO5A AIMP1 MYO9B RPS3 INTS1 FKBP11 ATP8A1 PIK3C2A NCAPD2 FKBP8 DDX24 HNRNPLL PIGO KIFC1 CARMIL2 NVL ARFGEF2 RNF213 PSTPIP1 OPA1 PMVK MTOR PRF1	9.08e-10	1168	200	27	19946888
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MYO5A INTS1 ANKHD1 DDB1 NCAPD2 ALDH18A1 DLD DDX24 HECTD1 SDHA DHX16 TUT7 NVL RIF1 MTOR MACF1 SNRNP200 KDM1A	5.22e-08	653	200	18	22586326
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	HK2 ABCF3 MYO5A MYO9B RPS3 ANKHD1 DDB1 PIK3C2A RPTOR A2ML1 NCAPD2 ALDH18A1 PRR14L DDX24 DHX16 HDAC6 PKP4 TUT7 KIF20B WDR74 RIF1 MACF1 RAI14 SCRIB SNRNP200 KDM1A	7.93e-08	1353	200	26	29467282
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	LPCAT1 ABCF3 AIMP1 DDB1 CADM1 MAVS PIK3C2A A2ML1 NCAPD2 ALDH18A1 DLD DDX24 GNL1 HDAC6 NTMT1 ARFGEF1 RNF213 EFHD2 IDE OPA1 FAF1 MTOR RAI14 SCRIB MMUT MVK	9.70e-08	1367	200	26	32687490
Pubmed	Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition.	HK2 RPTOR MTOR	1.87e-07	3	200	3	24462113
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	HK2 AIMP1 RPS3 ANKHD1 DDB1 RPTOR NCAPD2 ALDH18A1 DLD TDRD6 MYO18B DDX24 HNRNPLL SDHA KIFC1 DHX16 DNHD1 SYNE1 GNB1L IDE OPA1 RIF1 MTOR PUS1 SNRNP200 KDM1A	2.16e-07	1425	200	26	30948266
Pubmed	PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling.	DDB1 RPTOR MTOR	7.46e-07	4	200	3	34031390
Pubmed	Analysis of t(9;17)(q33.2;q25.3) chromosomal breakpoint regions and genetic association reveals novel candidate genes for bipolar disorder.	RPTOR RNF213 ENDOV	7.46e-07	4	200	3	25053281
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	HAUS6 ATP7A RPS3 DDB1 PRUNE1 NCAPD2 ALDH18A1 DIAPH3 SDHA HDAC6 GNB1L ANKRD50 OPA1 MACF1 RAI14 SCRIB SNRNP200	8.47e-07	708	200	17	39231216
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	TRPC4AP ANKHD1 DDB1 GGT7 PRUNE1 PASK DLD DIAPH3 HECTD1 HNRNPLL SDHA DUSP1 EFHD2 IDE ANKRD50 OPA1 MTOR PUS1 SNRNP200 KDM1A	1.02e-06	974	200	20	28675297
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	NLRP11 MYO5A RPS3 DDX24 SDHA DNHD1 SYNE1 MACF1 RAI14 SNRNP200	1.16e-06	234	200	10	36243803
Pubmed	Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer.	DDB1 RPTOR NCAPD2 DDX24 MTOR SNRNP200	1.74e-06	63	200	6	34718347
Pubmed	Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.	LPCAT1 TRPC4AP GGT7 DNHD1	2.38e-06	17	200	4	12693554
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	LPCAT1 INTS1 ARFGEF2 ARFGEF1 RNF213 OPA1 HTT	2.48e-06	104	200	7	31240132
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	EXTL3 PLCB1 PHLPP1 DHX16 WDR7 OPA1 KDM1A	2.65e-06	105	200	7	9628581
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	HAUS6 ATP7A RPS3 MAVS ALDH18A1 FKBP8 HNRNPLL WDR7 ARFGEF2 ARFGEF1 RNF213 ANKRD50 PKHD1L1 RIF1 RAI14 SCRIB SNRNP200	2.96e-06	777	200	17	35844135
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	HK2 ABCF3 AIMP1 RPS3 DDB1 GSPT2 NCAPD2 DLD HECTD1 GNL1 EFL1 ARFGEF2 SHMT1 EFHD2 IDE FAF1 RNF123 MTOR PUS1 MACF1 ELP2 SNRNP200 MVK HTT	3.78e-06	1455	200	24	22863883
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	MYO5A RPS3 ATP8A1 PIK3C2A RPTOR PLCB1 WDR7 PKP4 FMN2 MACF1 HTT	6.04e-06	347	200	11	17114649
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	ZNF143 HK2 ANKHD1 DENND5A FKBP8 METTL16 KIFC1 DHX16 PKP4 TUT7 GPAM ANKRD50 SBNO2 ELP2 SCRIB	6.14e-06	650	200	15	38777146
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	FSIP2 RPTOR METTL16 EFL1 HDAC6 SYNE1 NVL RIF1	6.30e-06	168	200	8	30631154
Pubmed	Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptor.	DDB1 RPTOR MTOR	6.45e-06	7	200	3	23297343
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	HK2 ABCF3 AIMP1 DDB1 ALDH18A1 FKBP8 GNL1 KIFC1 DHX16 OPA1 FAF1 RIF1 CSN2 ELP2 SCRIB	6.49e-06	653	200	15	33742100
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	LPCAT1 HK2 AIMP1 GGT7 JAG2 RPTOR NCAPD2 FKBP8 METTL16 SLC30A9 HECTD1 SDHA TUT7 ARFGEF1 OPA1 FAF1 MTOR SCRIB	9.65e-06	942	200	18	31073040
Pubmed	mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase.	DDB1 RPTOR MTOR	1.03e-05	8	200	3	18235224
Pubmed	Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.	RPTOR FKBP8 MTOR	1.03e-05	8	200	3	17991864
Pubmed	Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.	RPTOR GNB1L MTOR	1.03e-05	8	200	3	15268862
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	RPS3 SEMA5B PLCB1 DNHD1 ZNF618 SYNE1 RNF213 MUC5AC	1.38e-05	187	200	8	26460568
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TRPC4AP TTLL3 MYO5A AIMP1 OBSCN ACVR2B PCNX2 JAG2 RPTOR DENND5A HECTD1 MRPL42 RNF213 IDE PPM1K FAF1 SBNO2 PLEKHG4B CCNG2 MACF1 RAI14 TANGO2 HTT	1.74e-05	1489	200	23	28611215
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	HAUS6 RPS3 ANKHD1 PRUNE1 NCAPD2 DIAPH3 EFHD2 TAF3 RAI14 SCRIB SNRNP200 KDM1A HTT	1.98e-05	549	200	13	38280479
Pubmed	Late-gestational systemic hypoxia leads to a similar early gene response in mouse placenta and developing brain.	HK2 EGLN3 DUSP1	2.18e-05	10	200	3	20926767
Pubmed	Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy.	ZNF143 RPS3 SDHA MRPL42	2.25e-05	29	200	4	35013307
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	MYO5A MYO9B NCAPD2 HECTD1 TUT7 ARFGEF2 MTOR SNRNP200	2.40e-05	202	200	8	33005030
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	LPCAT1 HK2 ABCF3 AIMP1 RPS3 ANKHD1 DDB1 GSPT2 NCAPD2 ALDH18A1 DIAPH3 DDX24 HECTD1 GNL1 SDHA HDAC6 GNB1L EFHD2 OPA1 RIF1 MACF1 SNRNP200	2.44e-05	1415	200	22	28515276
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SPEG KLHL32 TRIL DHX16 WDR7 ZSWIM5 SYNE1 HEATR5A OPA1 MACF1 SCRIB	2.66e-05	407	200	11	12693553
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	LPCAT1 CRACR2B ANKHD1 DDB1 ABCA7 PASK RPTOR FKBP8 DDX24 HDAC6 ZNF618 PKP4 RNF213 OPA1 TAF3 FMN2 MACF1 SCRIB KDM1A	2.68e-05	1116	200	19	31753913
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	HK2 FSIP2 MAVS ALDH18A1 DLD FKBP8 SDHA MRPL42 SHMT1 GPAM IDE PPM1K NUDT13 OPA1 OXNAD1 QRSL1 MMUT	2.85e-05	926	200	17	20877624
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	RPS3 ANKHD1 DDB1 RPTOR A2ML1 NCAPD2 ALDH18A1 FKBP8 HECTD1 SDHA GNB1L ELP2 SCRIB	2.98e-05	571	200	13	37167062
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	LPCAT1 INTS1 DDB1 CADM1 DLD PRR14L SDHA SYNE1 PPM1K OPA1 RIF1 RAI14 SNRNP200	3.09e-05	573	200	13	28330616
Pubmed	The mTORC1 component RPTOR is required for maintenance of the foundational spermatogonial stem cell pool in mice†.	RPTOR MTOR	3.29e-05	2	200	2	30202948
Pubmed	Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation.	MMAA MMUT	3.29e-05	2	200	2	20876572
Pubmed	Allosteric Regulation of Oligomerization by a B12 Trafficking G-Protein Is Corrupted in Methylmalonic Aciduria.	MMAA MMUT	3.29e-05	2	200	2	31056463
Pubmed	mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells.	PHLPP1 MTOR	3.29e-05	2	200	2	21177869
Pubmed	Assignment of CD163B, the gene encoding M160, a novel scavenger receptor, to human chromosome 12p13.3 by in situ hybridization and somatic cell hybrid analysis.	CD163 CD163L1	3.29e-05	2	200	2	11124526
Pubmed	Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1/WDR74 Important for Localization and Interaction with Rix7/NVL2.	NVL WDR74	3.29e-05	2	200	2	28416111
Pubmed	Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice.	RPTOR MTOR	3.29e-05	2	200	2	18270303
Pubmed	Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.	ARFGEF2 ARFGEF1	3.29e-05	2	200	2	23918382
Pubmed	Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor.	EPOR SCRIB	3.29e-05	2	200	2	29282252
Pubmed	Histone deacetylase 6 regulates cytokinesis and erythrocyte enucleation through deacetylation of formin protein mDia2.	DIAPH3 HDAC6	3.29e-05	2	200	2	28255013
Pubmed	Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.	ARFGEF2 ARFGEF1	3.29e-05	2	200	2	17360629
Pubmed	Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.	ARFGEF2 ARFGEF1	3.29e-05	2	200	2	10716990
Pubmed	LSD1 negatively regulates autophagy through the mTOR signaling pathway in ovarian cancer cells.	MTOR KDM1A	3.29e-05	2	200	2	29749504
Pubmed	Membrane association of the Arabidopsis ARF exchange factor GNOM involves interaction of conserved domains.	ARFGEF2 ARFGEF1	3.29e-05	2	200	2	18203920
Pubmed	Deletion of mTORC1 Activity in CD4+ T Cells Is Associated with Lung Fibrosis and Increased γδ T Cells.	RPTOR MTOR	3.29e-05	2	200	2	27649073
Pubmed	mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors.	RPTOR MTOR	3.29e-05	2	200	2	29786082
Pubmed	Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning.	RPTOR MTOR	3.29e-05	2	200	2	27018708
Pubmed	The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity.	RPTOR MTOR	3.29e-05	2	200	2	16847060
Pubmed	Inhibition of apoptosis signal-regulating kinase 1 reduces endoplasmic reticulum stress and nuclear huntingtin fragments in a mouse model of Huntington disease.	MAP3K5 HTT	3.29e-05	2	200	2	19646509
Pubmed	Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.	ARFGEF2 ARFGEF1	3.29e-05	2	200	2	18417613
Pubmed	mTOR kinase-dependent, but raptor-independent regulation of downstream signaling is important for cell cycle exit and myogenic differentiation.	RPTOR MTOR	3.29e-05	2	200	2	25486193
Pubmed	Human MMAA induces the release of inactive cofactor and restores methylmalonyl-CoA mutase activity through their complex formation.	MMAA MMUT	3.29e-05	2	200	2	28943303
Pubmed	FKBP38 suppresses endometrial cancer cell proliferation and metastasis by inhibiting the mTOR pathway.	FKBP8 MTOR	3.29e-05	2	200	2	38218360
Pubmed	FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection.	MAVS FAF1	3.29e-05	2	200	2	30472208
Pubmed	KDM1A inhibition augments the efficacy of rapamycin for the treatment of endometrial cancer.	MTOR KDM1A	3.29e-05	2	200	2	34673129
Pubmed	Energetics of interaction between the G-protein chaperone, MeaB, and B12-dependent methylmalonyl-CoA mutase.	MMAA MMUT	3.29e-05	2	200	2	16641088
Pubmed	MYO18B promotes hepatocellular carcinoma progression by activating PI3K/AKT/mTOR signaling pathway.	MYO18B MTOR	3.29e-05	2	200	2	30390677
Pubmed	Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases.	SPEG OBSCN	3.29e-05	2	200	2	15185077
Pubmed	Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo.	RNF213 RNF123	3.29e-05	2	200	2	26126547
Pubmed	Fv-2: identification and location of a second gene governing the spleen focus response to Friend leukemia virus in mice.	MYO5A MST1R	3.29e-05	2	200	2	5449211
Pubmed	FBXW10 promotes hepatocarcinogenesis in male patients and mice.	FBXW10B FBXW10	3.29e-05	2	200	2	31400758
Pubmed	NLRP11 disrupts MAVS signalosome to inhibit type I interferon signaling and virus-induced apoptosis.	NLRP11 MAVS	3.29e-05	2	200	2	29097393
Pubmed	Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking.	RPTOR MTOR	3.29e-05	2	200	2	17301289
Pubmed	Elevated Hexokinase II Expression Confers Acquired Resistance to 4-Hydroxytamoxifen in Breast Cancer Cells.	HK2 MTOR	3.29e-05	2	200	2	31519767
Pubmed	HDAC6 regulates primordial follicle activation through mTOR signaling pathway.	HDAC6 MTOR	3.29e-05	2	200	2	34052832
Pubmed	Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.	FBXW10B FBXW10	3.29e-05	2	200	2	37450367
Pubmed	Conditional Knockout of Raptor/mTORC1 Results in Dentin Malformation.	RPTOR MTOR	3.29e-05	2	200	2	30984011
Pubmed	Protection and reactivation of human methylmalonyl-CoA mutase by MMAA protein.	MMAA MMUT	3.29e-05	2	200	2	21138732
Pubmed	Hepatic peroxisomal β-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation.	RPTOR MTOR	3.29e-05	2	200	2	32687428
Pubmed	Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.	ARFGEF2 ARFGEF1	3.29e-05	2	200	2	10212200
Pubmed	Dysregulation of Rnf 213 gene contributes to T cell response via antigen uptake, processing, and presentation.	RNF213 RNF123	3.29e-05	2	200	2	33973242
Pubmed	Retinoic Acid-Induced Protein 14 (RAI14) Promotes mTOR-Mediated Inflammation Under Inflammatory Stress and Chemical Hypoxia in a U87 Glioblastoma Cell Line.	MTOR RAI14	3.29e-05	2	200	2	30554401
Pubmed	Mitotic raptor promotes mTORC1 activity, G(2)/M cell cycle progression, and internal ribosome entry site-mediated mRNA translation.	RPTOR MTOR	3.29e-05	2	200	2	20439490
Pubmed	The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor.	EPOR INPP5D	3.29e-05	2	200	2	10660611
Pubmed	RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.	RPS3 DDB1 ALDH18A1 FKBP8 SDHA NTMT1 RNF213 OPA1 SCRIB SNRNP200	3.36e-05	344	200	10	36282215
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	MYBPH HK2 OBSCN MAP3K5 PIK3C2A MYO18B SYNE1 MYOM3 ZNF407 ANKRD50 FAF1 MACF1	3.44e-05	497	200	12	23414517
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	ABCF3 INTS1 DDB1 NCAPD2 DIAPH3 HNRNPLL ARFGEF2 FAF1 RIF1 MACF1 SCRIB SNRNP200 KDM1A	3.62e-05	582	200	13	20467437
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	MYO5A AIMP1 MYO9B DDB1 DLD DDX24 HECTD1 KIFC1 TUT7 NVL KIF20B WDR74 RIF1 MACF1 SNRNP200	3.73e-05	759	200	15	35915203
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	HAUS6 ANKHD1 RPTOR ARFGEF2 ARFGEF1 MTOR SCRIB SNRNP200	3.74e-05	215	200	8	35973513
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MYO5A CADM1 PHLPP1 ALDH18A1 FKBP8 EFL1 DUSP1 PKP4 RNF213 IDE PPM1K OPA1 RIF1 PUS1 FMN2 RAI14 ELP2 SCRIB	3.98e-05	1049	200	18	27880917
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	ATP7A MYO5A DDB1 PASK PIK3C2A DLD DIAPH3 FKBP8 SLC30A9 DDX24 SDHA SYNE1 PKP4 GNB1L NVL SHMT1 WDR74 MACF1 ELP2 SCRIB SNRNP200 QRSL1	5.10e-05	1487	200	22	33957083
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	TOGARAM1 PASK PLCB1 PHLPP1 SYNE1 MACF1 SCRIB SNRNP200	5.15e-05	225	200	8	12168954
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	HK2 DDB1 MAVS PIK3C2A RPTOR DIAPH3 FKBP8 SLC30A9 DDX24 GNL1 SDHA MRPL42 SYNE1 TUT7 RNF213 GPAM IDE OPA1 GEMIN7 PUS1 QRSL1 MMUT	5.57e-05	1496	200	22	32877691
Pubmed	Expression of multiple formins in adult tissues and during developmental stages of mouse brain.	DIAPH3 FHOD3 FMN2	6.51e-05	14	200	3	26272686
Pubmed	Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7.	MYO9B RPS3 DDB1 NCAPD2 WDR7 NVL OPA1	7.32e-05	175	200	7	37866880
Pubmed	Huntingtin functions as a scaffold for selective macroautophagy.	RPTOR MTOR HTT	8.10e-05	15	200	3	25686248
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	HAUS6 INTS1 ANKHD1 DDB1 HNRNPLL WDR74 GEMIN7 SCRIB	8.57e-05	242	200	8	34011540
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	HK2 GNL1 HDAC6 ARFGEF1 MTOR ELP2 MMUT	9.69e-05	183	200	7	31932471
Pubmed	Distribution and association of mTOR with its cofactors, raptor and rictor, in cumulus cells and oocytes during meiotic maturation in mice.	RPTOR MTOR	9.83e-05	3	200	2	23440873
Pubmed	Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity.	ARFGEF2 ARFGEF1	9.83e-05	3	200	2	19332778
Pubmed	Long-term outcome in methylmalonic acidurias is influenced by the underlying defect (mut0, mut-, cblA, cblB).	MMAA MMUT	9.83e-05	3	200	2	17597648
GeneFamily	WD repeat domain containing	FBXW10B PEX7 RPTOR WDR17 FBXW10 WDR7 GNB1L WDR74 ELP2	1.96e-04	262	139	9	362
GeneFamily	MTOR complex 1\|MTOR complex 2	RPTOR MTOR	3.49e-04	4	139	2	1332
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	CD163 SSC4D CD163L1	1.14e-03	27	139	3	1253
GeneFamily	Fibronectin type III domain containing	MYBPH EPOR OBSCN MYOM3 FNDC4 EPHA8	1.49e-03	160	139	6	555
GeneFamily	Fibronectin type III domain containing\|I-set domain containing\|Myosin binding proteins	MYBPH MYOM3	1.59e-03	8	139	2	658
GeneFamily	Ankyrin repeat domain containing	ANKHD1 ASB10 HECTD1 ANKRD30BL ANKRD50 KANK3 RAI14	2.70e-03	242	139	7	403
GeneFamily	WD repeat domain containing\|F-box and WD repeat domain containing	FBXW10B FBXW10	3.08e-03	11	139	2	559
ToppCell	COVID-19_Severe-gd_T\|COVID-19_Severe / Disease condition and Cell class	LPCAT1 MYO9B HOPX CADM1 SYNE1 TUT7 RNF213 EFHD2 GOLGA8Q SLC15A4 PRF1 MACF1	4.78e-11	184	200	12	791f1bcb954aadc63d4117c400537d036f68734d
ToppCell	normal-na-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	RPS3 HOPX FKBP11 PASK ATP8A1 SYNE1 RNF213 PRF1 OXNAD1	2.82e-07	197	200	9	b5b333e98753946793ceb45e2d85c25ef53568b4
ToppCell	normal-na-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|normal / PBMC cell types (v2) per disease, treatment status, and sex	RPS3 HOPX FKBP11 PASK ATP8A1 SYNE1 RNF213 PRF1 OXNAD1	2.82e-07	197	200	9	4cec48e202f4583c9328d4b722c49ed3471ec173
ToppCell	COVID_non-vent-Lymphocytic-ILC-NK_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	LPCAT1 HOPX SYNE1 GOLGA8R RNF213 EFHD2 GOLGA8Q PRF1 MACF1	3.07e-07	199	200	9	ed35d747f11f6ea6a5cb7061057f0a98d9e0db99
ToppCell	Control-NK\|Control / Disease condition and Cell class	LPCAT1 HOPX SYNE1 RNF213 EFHD2 SIGLEC7 SLC15A4 PRF1 MACF1	3.07e-07	199	200	9	f3316fb97c6065286ffd22a0ad9fe7aa5b3b5650
ToppCell	COVID_vent-Lymphocytic-ILC-NK_cell\|COVID_vent / Disease condition, Lineage, Cell class and subclass	LPCAT1 HOPX SYNE1 GOLGA8R RNF213 EFHD2 GOLGA8Q PRF1 MACF1	3.07e-07	199	200	9	5f914962e2572b0c6372465b81b7496fa663d93c
ToppCell	severe-gd_T\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RPS3 HOPX FKBP11 PLCB1 DDX24 SYNE1 RNF213 EFHD2 PRF1	3.07e-07	199	200	9	e5a17a9f8f3be05d6abe1116607d17633df3c7ef
ToppCell	COVID_non-vent-Lymphocytic-ILC\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	LPCAT1 HOPX SYNE1 GOLGA8R RNF213 EFHD2 GOLGA8Q PRF1 MACF1	3.07e-07	199	200	9	df4f7d5be099e3e6054f3b812ccf70251664e4c0
ToppCell	COVID_vent-Lymphocytic-ILC\|COVID_vent / Disease condition, Lineage, Cell class and subclass	LPCAT1 HOPX SYNE1 GOLGA8R RNF213 EFHD2 GOLGA8Q PRF1 MACF1	3.07e-07	199	200	9	e3ff7fa1b1de1aaf6b46cdf49afa95bad457728a
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-MAIT\|COVID-19_Severe / Disease, condition lineage and cell class	RPS3 HOPX FKBP11 PLCB1 DDX24 DUSP1 PRF1 OXNAD1 RORC	3.20e-07	200	200	9	b8cfccecff9900aee323c40e771c94e560b8c488
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_4\|356C / Donor, Lineage, Cell class and subclass (all cells)	DCBLD1 PEX7 CD163 SSC4D SPOCD1 GPAM HEATR5A CCNG2	7.29e-07	162	200	8	7d43d59531cbefe3ac94953b7faf7156b2a31441
ToppCell	COVID-19_Mild-gd_T\|COVID-19_Mild / Disease condition and Cell class	HOPX CADM1 PLCB1 SYNE1 RNF213 EFHD2 PRF1 MACF1	1.82e-06	183	200	8	f593a89b0aa8fffdfa403769916facfd30358521
ToppCell	mild_COVID-19-CD4+_CTL\|mild_COVID-19 / disease group, cell group and cell class (v2)	RPS3 HOPX FKBP11 HNRNPLL SYNE1 RNF213 EFHD2 PRF1	2.14e-06	187	200	8	49196d07e4716c87d33229a4569bdb6b4613b3eb
ToppCell	COVID-19-kidney-VWF+PLVAP+VCAM1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	INPP5D GFRA1 PIK3C2A PLCB1 PKP4 SH2D3C KANK3 RAI14	2.32e-06	189	200	8	c121817ddad164e9cfe382c43d0cbc9215508d02
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_3\|Classical_Monocyte / Disease condition and Cell class	EPOR ZNF143 DCBLD1 ANKHD1 METTL16 SHMT1 MTOR MVK	2.32e-06	189	200	8	8b6f92ccfffc743c07201bc971b3dc1a6fa14ccc
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_3\|COVID-19_Convalescent / Disease condition and Cell class	EPOR ZNF143 DCBLD1 ANKHD1 METTL16 SHMT1 MTOR MVK	2.32e-06	189	200	8	732e8dcffcb634ca2968f9170c9c4b31dd5d4206
ToppCell	facs-Heart-LV-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN LRRC14B ASB10 MYO18B EGLN3 FHOD3 KLHL38 RORC	2.51e-06	191	200	8	9d7d680da3979e256191b534ebd14c5383e0cf93
ToppCell	facs-Heart-LV-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN LRRC14B ASB10 MYO18B EGLN3 FHOD3 KLHL38 RORC	2.51e-06	191	200	8	543da1197c7e62f2c9cbd4a51414bbaaa6d1a92f
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HOPX FKBP11 PLCB1 SYNE1 DUSP1 EFHD2 PRF1 MACF1	2.60e-06	192	200	8	ce867b6e78c1d8f30dff81bf572a78a897bc7625
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HOPX FKBP11 PLCB1 SYNE1 DUSP1 EFHD2 PRF1 MACF1	2.60e-06	192	200	8	58a7829b411b02b422ef75e2277a868969cc23e8
ToppCell	10x5'-blood-Lymphocytic_NK-NK_CD16\|blood / Manually curated celltypes from each tissue	LPCAT1 HOPX FKBP11 ATP8A1 SYNE1 EFHD2 SLC15A4 PRF1	2.81e-06	194	200	8	c34a32f1cfe3e597cb0f91ba5bdd3e114e9f3d2e
ToppCell	3'_v3-bone_marrow-Lymphocytic_NK-NK_CD16\|bone_marrow / Manually curated celltypes from each tissue	LPCAT1 HOPX SYNE1 RNF213 EFHD2 SIGLEC7 SLC15A4 PRF1	2.81e-06	194	200	8	7773501e076d470158dbc1d7f10c67152b326eb7
ToppCell	normal_Pleural_Fluid-T/NK_cells-CD8_low_T\|normal_Pleural_Fluid / Location, Cell class and cell subclass	RPS3 HOPX FKBP11 HNRNPLL SYNE1 RNF213 PSTPIP1 PRF1	2.81e-06	194	200	8	11eb317f66cbced1cedadd6daba443c4d832c49f
ToppCell	10x5'-blood-Lymphocytic_NK\|blood / Manually curated celltypes from each tissue	LPCAT1 HOPX FKBP11 ATP8A1 SYNE1 EFHD2 SLC15A4 PRF1	2.92e-06	195	200	8	c1db871e8e8e8b8d6a5798bc43eaf54e102b75eb
ToppCell	COVID-19_Severe-Lymphoid_T/NK-gd_T\|COVID-19_Severe / Disease group, lineage and cell class	LPCAT1 HOPX SYNE1 RNF213 EFHD2 GOLGA8Q PRF1 MACF1	2.92e-06	195	200	8	9990440bda7fac5d00ef80444fab07459be625e1
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-T_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ATP7A RPS3 FKBP11 ATP8A1 GVINP1 DDX24 HNRNPLL OXNAD1	3.03e-06	196	200	8	4a880a5d2c7047c050c7d6dd62186f35dc5c01f7
ToppCell	COVID-19_Severe-NK\|World / disease group, cell group and cell class	LPCAT1 HOPX FKBP11 SYNE1 RNF213 EFHD2 SLC15A4 PRF1	3.03e-06	196	200	8	f46ca7cc2d8407d0dcaa77c4b16a2c1f2a23734d
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RPS3 HOPX FKBP11 SYNE1 PSTPIP1 PPM1K PRF1 OXNAD1	3.15e-06	197	200	8	927bf36bad3bcb7346c13b660777c1c0de7dc322
ToppCell	BAL-Mild-Lymphocyte-T/NK-CD8+_T-CD8+_T_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RPS3 HOPX FKBP11 SYNE1 PSTPIP1 PPM1K PRF1 OXNAD1	3.15e-06	197	200	8	3e09158507df08c08e08613ce23617206280c911
ToppCell	mild_COVID-19_(asymptomatic)-NK\|World / disease group, cell group and cell class (v2)	HOPX FKBP11 SYNE1 RNF213 EFHD2 SLC15A4 PRF1 MACF1	3.27e-06	198	200	8	7a0aac52d785037455e068e1b25de4b2bf0fff79
ToppCell	healthy_donor-Lymphocytic-ILC-NK_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	LPCAT1 HOPX SYNE1 GOLGA8R RNF213 EFHD2 PRF1 MACF1	3.27e-06	198	200	8	d7053a898e04478c577381085f615edaad3cdc5b
ToppCell	healthy_donor-Lymphocytic-ILC\|healthy_donor / Disease condition, Lineage, Cell class and subclass	LPCAT1 HOPX SYNE1 GOLGA8R RNF213 EFHD2 PRF1 MACF1	3.27e-06	198	200	8	aa33be29e26f1b8facfc894413099083ae3bbb1b
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LPCAT1 HOPX FKBP11 SYNE1 RNF213 EFHD2 PRF1 MACF1	3.40e-06	199	200	8	4820f5bcd7bc34c2ebf6a3422cc8eb383a3b5a4e
ToppCell	Sigmoid-NK_cell-NK\|Sigmoid / Region, Cell class and subclass	LPCAT1 HOPX JAG2 FNDC4 GOLGA8R PSTPIP1 SIGLEC7 PRF1	3.40e-06	199	200	8	5aa943ef7a1764ce4e95a7163aaabe2ee89eb870
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RPS3 HOPX ATP8A1 SYNE1 RNF213 PSTPIP1 PRF1 OXNAD1	3.40e-06	199	200	8	8f2b57cf2f932f20ea029132d8bda01aac774571
ToppCell	Sigmoid-NK_cell\|Sigmoid / Region, Cell class and subclass	LPCAT1 HOPX JAG2 FNDC4 GOLGA8R PSTPIP1 SIGLEC7 PRF1	3.40e-06	199	200	8	653965a8bb09abcab7d275b01d361b7b4e3fdd58
ToppCell	Sigmoid-(0)_NK_cell\|Sigmoid / shred on region, Cell_type, and subtype	LPCAT1 HOPX JAG2 FNDC4 GOLGA8R PSTPIP1 SIGLEC7 PRF1	3.40e-06	199	200	8	5be944da7a6c5f6076ed508a64f77d90836becd7
ToppCell	mild-MAIT\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	FKBP11 PLCB1 DDX24 SYNE1 RNF213 PRF1 MACF1 RORC	3.40e-06	199	200	8	cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LPCAT1 HOPX FKBP11 SYNE1 RNF213 EFHD2 PRF1 MACF1	3.40e-06	199	200	8	eb05ccae5187e4701bbbe6d714a6d2808fbcf306
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	LPCAT1 HOPX FKBP11 SYNE1 RNF213 EFHD2 PRF1 MACF1	3.40e-06	199	200	8	10c8729b779073c3bf808e85958d59147f0be5c5
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LPCAT1 HOPX FKBP11 SYNE1 RNF213 EFHD2 PRF1 MACF1	3.40e-06	199	200	8	867fd292f3879982422e840e087bfdb3b21a8715
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	LPCAT1 HOPX FKBP11 SYNE1 RNF213 EFHD2 PRF1 MACF1	3.40e-06	199	200	8	5e9fe852a70546c9d235414a2c26ca3e67ba6eb9
ToppCell	Control-Lymphoid_T/NK-NK\|Control / Disease group, lineage and cell class	LPCAT1 HOPX FKBP11 SYNE1 RNF213 EFHD2 PRF1 MACF1	3.40e-06	199	200	8	94b2693a8378b9b2c58c6aebb2c6658d75b2e3de
ToppCell	Sigmoid-(0)_NK_cell-(00)_NK\|Sigmoid / shred on region, Cell_type, and subtype	LPCAT1 HOPX JAG2 FNDC4 GOLGA8R PSTPIP1 SIGLEC7 PRF1	3.40e-06	199	200	8	689e8675d2d40cfb1bd200767a35dcc6664214d9
ToppCell	PBMC-Control-Lymphocyte-T/NK-NK_cell-NK\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	LPCAT1 HOPX FKBP11 SYNE1 RNF213 EFHD2 PRF1 MACF1	3.40e-06	199	200	8	d2c9fb69e5ef75778a1652da293fcf8cfa7ecfcc
ToppCell	mild-gd_T\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RPS3 HOPX FKBP11 CADM1 DDX24 SYNE1 EFHD2 PRF1	3.52e-06	200	200	8	2c21ede46a42b8e2f8e99ecca365baa52056eb17
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial-Astrocyte\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	HK2 HOPX CD163 C11orf68 SDC2 EGLN3 ZNF407 SCRIB	3.52e-06	200	200	8	98a994692440cb4f505b050276f0c8022c814a21
ToppCell	severe-gd_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HOPX FKBP11 DDX24 SYNE1 RNF213 EFHD2 PRF1 EPHA8	3.52e-06	200	200	8	2253d74049cc49c92e897ff4aa298d913daeb739
ToppCell	severe-MAIT\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RPS3 HOPX FKBP11 PLCB1 DDX24 DUSP1 PRF1 RORC	3.52e-06	200	200	8	1daf43f1bdd49585dce5e957820554d7f3c1bd4a
ToppCell	Control-Control-Lymphocyte-T/NK-NK\|Control / Disease, condition lineage and cell class	LPCAT1 HOPX FKBP11 SYNE1 RNF213 EFHD2 PRF1 MACF1	3.52e-06	200	200	8	c64c27dbf4df42ca2ad2bd94b50fab87b4050ef3
ToppCell	severe-CD8+_Tem\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RPS3 HOPX FKBP11 DDX24 SYNE1 RNF213 EFHD2 PRF1	3.52e-06	200	200	8	aaa2cd326dc15dee2fd975ca133359c5826f6a75
ToppCell	mild-gd_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HOPX PLCB1 DDX24 SYNE1 RNF213 EFHD2 PRF1 MACF1	3.52e-06	200	200	8	109f673a4967ffa52270a0b4f818b3461288db44
ToppCell	mild-NK\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	LPCAT1 HOPX FKBP11 SYNE1 RNF213 EFHD2 PRF1 MACF1	3.52e-06	200	200	8	a11fb1d7e124c352eb73fea0e0ec0fed577c97f7
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	LPCAT1 HOPX SYNE1 GOLGA8R RNF213 GOLGA8Q PRF1 MACF1	3.52e-06	200	200	8	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Macroglial\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	HK2 HOPX CD163 C11orf68 SDC2 EGLN3 ZNF407 SCRIB	3.52e-06	200	200	8	ef222dc4a205d670172dae74990bdb952ac92e5b
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-gd_T\|COVID-19_Severe / Disease, condition lineage and cell class	LPCAT1 HOPX SYNE1 RNF213 EFHD2 GOLGA8Q PRF1 MACF1	3.52e-06	200	200	8	f72bc3f6606ae77fe1b0a972e35b3ce0727804d9
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_C\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	LPCAT1 HOPX TNFAIP8L2 GOLGA8R EFHD2 SIGLEC7 PRF1	5.08e-06	149	200	7	95b21d67d6c335330a508f78d5cc074fdaf92275
ToppCell	facs-Aorta-Heart-18m-Mesenchymal-fibrocyte\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NTSR2 ACVR2B ABCA7 CD163L1 FBXW10 OXNAD1 IRGC	6.87e-06	156	200	7	5b56217336771baf57d791efcb4e206c6aea83b1
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LPCAT1 PEX7 ACVR2B PRR14L MYOM3 KIF20B RIF1	1.11e-05	168	200	7	08f6e171a1ea5cf65149744296d0fcd6c7b9684e
ToppCell	10x5'-GI_small-bowel-Lymphocytic_NK-NK_CD16\|GI_small-bowel / Manually curated celltypes from each tissue	LPCAT1 SYNE1 EFHD2 GOLGA8Q SIGLEC7 SLC15A4 PRF1	1.25e-05	171	200	7	1ee505b91f15191d294a5d491ecdf154c08b8622
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN NTSR2 LRRC14B ST8SIA5 MYO18B FHOD3 KLHL38	1.30e-05	172	200	7	ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN NTSR2 LRRC14B ST8SIA5 MYO18B FHOD3 KLHL38	1.30e-05	172	200	7	bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCell	15-Trachea-Immune-Hematopoietic,_Natural_Killer_Cell\|Trachea / Age, Tissue, Lineage and Cell class	LPCAT1 HOPX INPP5D EFHD2 PSTPIP1 SIGLEC7 PRF1	1.35e-05	173	200	7	6884af1492e8a3bb92a33303d4d5ec3343e88b00
ToppCell	10x5'-blood-Lymphocytic_Invariant-Inducer-like-MAIT\|blood / Manually curated celltypes from each tissue	HOPX PRSS22 FKBP11 DUSP1 FHOD3 PRF1 RORC	1.45e-05	175	200	7	b4e4b66e89f79999768a6192c8404cb2465f920b
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LPCAT1 SYNE1 TUT7 RNF213 GOLGA8Q PRF1 MACF1	1.56e-05	177	200	7	d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	LPCAT1 SYNE1 TUT7 RNF213 GOLGA8Q PRF1 MACF1	1.56e-05	177	200	7	f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCell	COVID-19_Mild-Lymphoid_T/NK-NK_activated\|COVID-19_Mild / Disease group, lineage and cell class	LPCAT1 SYNE1 TUT7 RNF213 GOLGA8Q PRF1 MACF1	1.56e-05	177	200	7	6978a22fef40c8b455342373abe7593f5ede0fa4
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	LPCAT1 SYNE1 TUT7 RNF213 GOLGA8Q PRF1 MACF1	1.56e-05	177	200	7	936ab2b180a052387124f68d0c7f41c0b164e748
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	LPCAT1 SYNE1 TUT7 RNF213 GOLGA8Q PRF1 MACF1	1.56e-05	177	200	7	d5aeda113afaa2425874394610344570c9078478
ToppCell	lymphoid-NK_cell-TNFRSF18+IL7R-_NK_cell\|World / Lineage, cell class and subclass	HOPX PRSS22 CRACR2B INSC DUSP1 SIGLEC7 PRF1	1.62e-05	178	200	7	0f95e2cd448a8e5eb23b29f57cf3321ff8b1a672
ToppCell	COVID-19_Severe-Lymphoid_T/NK-MAIT\|COVID-19_Severe / Disease group, lineage and cell class	HOPX FKBP11 PLCB1 DDX24 PRF1 OXNAD1 RORC	1.87e-05	182	200	7	19045db5c726c06ec6e4feb4311633c8164ddb3c
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SPEG ABCA7 SSC4D GPR143 FHOD3 LCT	1.97e-05	123	200	6	87401764a073c1808f214642a9c84299c78f7ec7
ToppCell	lymphoid-NK_cell-TNFRSF18+IL7R-_NK_cell\|lymphoid / Lineage, cell class and subclass	HOPX PRSS22 CRACR2B INSC DUSP1 SIGLEC7 PRF1	2.01e-05	184	200	7	62a3918705a3fcf3ef25c9ceb80f575a2e56ef76
ToppCell	Healthy-MAIT\|Healthy / disease group, cell group and cell class	RPS3 HOPX PRSS22 FKBP11 PLCB1 PRF1 RORC	2.15e-05	186	200	7	028061f06d86e75cb06db56b199594b80f23fa58
ToppCell	Mild-Lymphoid-T-NK\|Mild / Condition, Lineage, Cell class and cell subclass	RPS3 HOPX ATP8A1 SYNE1 PSTPIP1 PRF1 OXNAD1	2.15e-05	186	200	7	ed37a2df547661d22c1ed0b30cb1c19e489d9d0a
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LPCAT1 PRSS22 MAP3K5 CADM1 ATP8A1 PLEKHG4B RORC	2.23e-05	187	200	7	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	COPD-Lymphoid-NK\|COPD / Disease state, Lineage and Cell class	LPCAT1 HOPX INPP5D ATP8A1 PLCB1 SYNE1 PRF1	2.30e-05	188	200	7	c9a227c8e71b69929d43e9afb8306a95c8163778
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN NTSR2 KLHL32 LRRC14B MYO18B FHOD3 KLHL38	2.30e-05	188	200	7	90dc0e15798d0b984518ad58c7e416e30aff687a
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN NTSR2 KLHL32 LRRC14B MYO18B FHOD3 KLHL38	2.30e-05	188	200	7	f63dfd076ced81013918363282ae25cbbd8948ae
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN NTSR2 KLHL32 LRRC14B MYO18B FHOD3 KLHL38	2.30e-05	188	200	7	0554d542149cef654ff1e5e32dfbffd8990b52bd
ToppCell	facs-Heart-LA/RA-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN NTSR2 KLHL32 LRRC14B MYO18B FHOD3 KLHL38	2.38e-05	189	200	7	a08b2d0fa35ffa510050ecffdc68e1b79bbe1632
ToppCell	3'_v3-Lung-Lymphocytic_T_CD8-Tem/emra_CD8\|Lung / Manually curated celltypes from each tissue	RPS3 HOPX FKBP11 ATP8A1 SYNE1 PRF1 OXNAD1	2.38e-05	189	200	7	f43bb9db7bb2d19c9849cd3ed892fe3e09e7dfe2
ToppCell	facs-Heart-LA/RA\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN NTSR2 KLHL32 LRRC14B MYO18B FHOD3 KLHL38	2.38e-05	189	200	7	efa913d9c16fc32166b484d92b6449e8a0c59e03
ToppCell	Healthy-MAIT\|World / disease group, cell group and cell class	RPS3 HOPX PRSS22 FKBP11 PLCB1 PRF1 RORC	2.38e-05	189	200	7	2404254b7a31b4a931841232e07462a3ca855ad4
ToppCell	Control-Lymphoid-NK\|Control / Disease state, Lineage and Cell class	HOPX INPP5D ATP8A1 PLCB1 SYNE1 SLC15A4 PRF1	2.47e-05	190	200	7	f7bd8521a40ac30a64dc439f17e2f6c7d021ef65
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SPEG PIGO GPR143 PLEKHG4B PRF1 FMN2	2.47e-05	128	200	6	2cf0384240a4a663869cf6b27d954236f6214a9a
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	OBSCN CD163L1 CPNE9 PKHD1L1 EPHA8	2.52e-05	77	200	5	a799ccdb84014e978d9fbccf3d2fee8fbeac7b0c
ToppCell	IPF-Lymphoid-NK\|Lymphoid / Disease state, Lineage and Cell class	LPCAT1 HOPX PLCB1 SYNE1 EFHD2 SLC15A4 PRF1	2.55e-05	191	200	7	f2ddc0962007d7a4e78fbd916ebb62fc557d480a
ToppCell	3'_v3-Lung-Lymphocytic_T_CD8\|Lung / Manually curated celltypes from each tissue	RPS3 HOPX FKBP11 ATP8A1 SYNE1 PRF1 OXNAD1	2.64e-05	192	200	7	f53426b9b1a63529307751c490a5a6214e499317
ToppCell	human_hepatoblastoma-Tumor_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	ITFG2 CADM1 RPTOR PLCB1 ZSWIM5 ARFGEF2 GPAM	2.73e-05	193	200	7	503a979328c68b096680b71359a26f02fafdff35
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	HOPX FKBP11 ATP8A1 SYNE1 PSTPIP1 PRF1 OXNAD1	2.73e-05	193	200	7	778fcf8448e81fe18972d97ea8a30ab036d16fe5
ToppCell	COVID-19_Severe-CD8+_T_activated\|World / disease group, cell group and cell class	HOPX FKBP11 DDX24 SYNE1 RNF213 EFHD2 PRF1	2.73e-05	193	200	7	ddc1db516568e03be8e82b2ca770c67756418185
ToppCell	COPD-Lymphoid-NK\|Lymphoid / Disease state, Lineage and Cell class	LPCAT1 HOPX PLCB1 SYNE1 EFHD2 SLC15A4 PRF1	2.73e-05	193	200	7	0020249fa71afb500af73700543bb6f349be6b10
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-Activated_CD8_T\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RPS3 HOPX FKBP11 RNF213 PSTPIP1 PRF1 OXNAD1	2.82e-05	194	200	7	db15be55bb4d35b52d362f3025ecb13418ea3659
ToppCell	Healthy_donor-CD8+_Tem\|Healthy_donor / disease group, cell group and cell class (v2)	RPS3 HOPX FKBP11 ATP8A1 DDX24 SYNE1 PRF1	2.82e-05	194	200	7	bf2e889de60b2b452a41f4d59a0f2a1865f07184
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MYO9B HOPX SYNE1 EFHD2 SLC15A4 PRF1 MACF1	2.82e-05	194	200	7	24837a27b0041fe8c348225fa8b09b127d743603
ToppCell	lymphoid-NK_cell\|World / Lineage, cell class and subclass	LPCAT1 HOPX FKBP11 EFHD2 SIGLEC7 SLC15A4 PRF1	2.82e-05	194	200	7	4bf5a140be8691e4ec99d7ee15588fd48acd6fb5
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	HOPX FKBP11 ATP8A1 SYNE1 PSTPIP1 PRF1 OXNAD1	2.82e-05	194	200	7	64535db0420e53e4d777d2333b5051e63e8a3373
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_NK-natural_killer_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	LPCAT1 HOPX PIF1 SYNE1 RNF213 EFHD2 PRF1	2.82e-05	194	200	7	a3a81638b55cb5fc08fe83c8b88f68d49b87e6cb
ToppCell	lymphoid-NK_cell-NK_cell\|World / Lineage, cell class and subclass	LPCAT1 HOPX FKBP11 EFHD2 SIGLEC7 SLC15A4 PRF1	2.82e-05	194	200	7	7f5adc18e632109694446b8eb1543cbae62dccbe
Drug	isopentenol	SDHA PMVK MVK	6.20e-06	5	196	3	CID006440261
Drug	Nadolol [42200-33-9]; Up 200; 13uM; MCF7; HT_HG-U133A	EPOR TRPC4AP PEX7 MAP3K5 PRUNE1 METTL16 PIGO SHMT1 GPR143 CCNG2	7.42e-06	194	196	10	4139_UP
Drug	Eserine sulfate, physostigmine sulfate [64-47-1]; Down 200; 6.2uM; MCF7; HT_HG-U133A	PASK PLCB1 DUSP1 GNB1L GPR143 OPA1 SBNO2 CCNG2 MTOR MACF1	8.49e-06	197	196	10	2768_DN
Drug	phosphomevalonate	PEX7 SDHA PMVK MMUT MVK	8.76e-06	33	196	5	CID000000476
Disease	melanoma	EPOR RPS3 DCBLD1 MAP3K5 CD163L1 C11orf68 HDAC6 GPAM WDR74 KDM1A	5.19e-06	248	190	10	C0025202
Disease	Porokeratosis of Mibelli	PMVK MVK	4.12e-05	2	190	2	C0949506
Disease	response to irinotecan	DCBLD1 TRIL PLCB1	1.13e-04	15	190	3	EFO_0004829
Disease	Malignant neoplasm of breast	EPOR OBSCN JAG2 CADM1 SEMA5B PLCB1 BCAR3 SPOCD1 ZSWIM5 SYNE1 GNB1L ARFGEF2 SHMT1 RIF1 MTOR SLC28A1 PUS1 MACF1	2.14e-04	1074	190	18	C0006142
Disease	methylmalonic acidemia (implicated_via_orthology)	MMAA MMUT	2.45e-04	4	190	2	DOID:14749 (implicated_via_orthology)
Disease	ocular hypertension, response to triamcinolone acetonide	TTLL3 DENND5A TUT7 KIF20B	2.81e-04	49	190	4	EFO_0006954, EFO_1001069
Disease	porokeratosis (is_implicated_in)	PMVK MVK	4.07e-04	5	190	2	DOID:3805 (is_implicated_in)
Disease	kallikrein-7 measurement	CD163 CD163L1	4.07e-04	5	190	2	EFO_0008195
Disease	maple syrup urine disease (is_implicated_in)	DLD PPM1K	4.07e-04	5	190	2	DOID:9269 (is_implicated_in)
Disease	Methylmalonic acidemia	MMAA MMUT	4.07e-04	5	190	2	cv:C0268583
Disease	Maple Syrup Urine Disease	DLD PPM1K	6.08e-04	6	190	2	C0024776
Disease	Huntington's disease (implicated_via_orthology)	FKBP11 DUSP1 HTT	1.14e-03	32	190	3	DOID:12858 (implicated_via_orthology)
Disease	reticulocyte measurement	MYO9B HOPX INPP5D MAP3K5 GGT7 PLCB1 SPOCD1 GNL1 TUT7 ARFGEF2 FAF1 SBNO2 SLC9A5 SIGLEC7 KANK3 RAI14	1.36e-03	1053	190	16	EFO_0010700
Disease	Tremor, Neonatal	ATP7A HTR1A	1.44e-03	9	190	2	C0235843
Disease	Tremor, Perioral	ATP7A HTR1A	1.44e-03	9	190	2	C0235078
Disease	Nerve Tremors	ATP7A HTR1A	1.44e-03	9	190	2	C0235083
Disease	Tremor, Limb	ATP7A HTR1A	1.44e-03	9	190	2	C0235081
Disease	Tremor, Muscle	ATP7A HTR1A	1.44e-03	9	190	2	C0235082
Disease	Senile Tremor	ATP7A HTR1A	1.44e-03	9	190	2	C0149840
Disease	Pill Rolling Tremor	ATP7A HTR1A	1.44e-03	9	190	2	C0751564
Disease	Tremor, Semirhythmic	ATP7A HTR1A	1.44e-03	9	190	2	C0751565
Disease	2-hydroxyglutaric acid measurement	PLCB1 EGLN3	1.44e-03	9	190	2	EFO_0010446
Disease	Action Tremor	ATP7A HTR1A	1.44e-03	9	190	2	C0234376
Disease	Passive Tremor	ATP7A HTR1A	1.44e-03	9	190	2	C0234377
Disease	Static Tremor	ATP7A HTR1A	1.44e-03	9	190	2	C0234378
Disease	Resting Tremor	ATP7A HTR1A	1.44e-03	9	190	2	C0234379
Disease	Intermittent Tremor	ATP7A HTR1A	1.44e-03	9	190	2	C0234372
Disease	Fine Tremor	ATP7A HTR1A	1.44e-03	9	190	2	C0234373
Disease	Coarse Tremor	ATP7A HTR1A	1.44e-03	9	190	2	C0234374
Disease	Massive Tremor	ATP7A HTR1A	1.44e-03	9	190	2	C0234375
Disease	Persistent Tremor	ATP7A HTR1A	1.44e-03	9	190	2	C0234370
Disease	Continuous Tremor	ATP7A HTR1A	1.44e-03	9	190	2	C0234371
Disease	Erythrocytosis	EPOR EGLN3	1.44e-03	9	190	2	C1527405
Disease	Darkness Tremor	ATP7A HTR1A	1.44e-03	9	190	2	C0234381
Disease	Involuntary Quiver	ATP7A HTR1A	1.44e-03	9	190	2	C1527384
Disease	Saturnine Tremor	ATP7A HTR1A	1.44e-03	9	190	2	C0040827
Disease	3-methyl-2-oxobutyrate measurement	PPM1K ANKRD50	1.79e-03	10	190	2	EFO_0021020
Disease	cancer antigen 125 measurement	D2HGDH MSLNL	1.79e-03	10	190	2	EFO_0010603
Disease	low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	GPAM FAF1 N6AMT1 MACF1 IRGC HTT	1.94e-03	200	190	6	EFO_0004611, EFO_0020945
Disease	Tremor	ATP7A HTR1A	2.18e-03	11	190	2	C0040822
Disease	Adenocarcinoma of lung (disorder)	HK2 FKBP11 ALDH18A1 MYO18B SHMT1 EPHA8	2.24e-03	206	190	6	C0152013
Disease	putamen volume change measurement	SH2D3C TAF3	3.07e-03	13	190	2	EFO_0021495
Disease	rhinitis (biomarker_via_orthology)	OPA1 MUC5AC	3.07e-03	13	190	2	DOID:4483 (biomarker_via_orthology)
Disease	transient cerebral ischemia (biomarker_via_orthology)	MAP3K5 DUSP1 MTOR KDM1A HTT	3.56e-03	157	190	5	DOID:224 (biomarker_via_orthology)
Disease	Alzheimer disease, dementia, family history of Alzheimer’s disease	DCBLD1 HNRNPLL FHOD3	3.67e-03	48	190	3	EFO_0009268, MONDO_0001627, MONDO_0004975
Disease	myocardial infarction (biomarker_via_orthology)	EPOR AIMP1 PLCB1 EGLN3 OPA1	3.86e-03	160	190	5	DOID:5844 (biomarker_via_orthology)
Disease	response to platinum based chemotherapy, magnesium measurement	RAI14 ENDOV	4.10e-03	15	190	2	EFO_0004647, EFO_0004845
Disease	Disease Exacerbation	DDB1 ABCA7 ABCC11 PUS1 KDM1A	4.39e-03	165	190	5	C0235874
Disease	body mass index, type 2 diabetes mellitus	FAF1 MTOR	4.66e-03	16	190	2	EFO_0004340, MONDO_0005148
Disease	revision of total joint arthroplasty, aseptic loosening	PHLPP1 SLC28A1	4.66e-03	16	190	2	EFO_0010725, EFO_0020974
Disease	Schizophrenia	MYO9B GFRA1 CD163 JAG2 PLCB1 SDHA HTR1A GNB1L SHMT1 IDE OPA1 SBNO2 MTOR	4.91e-03	883	190	13	C0036341
Disease	Metastatic melanoma	PASK MTOR EPHA8	5.12e-03	54	190	3	C0278883
Disease	Moyamoya Disease	ATP7A RNF213	5.26e-03	17	190	2	C0026654
Disease	Disorder of organic acid metabolism	MMAA MMUT	5.90e-03	18	190	2	cv:C1263739

Protein segments in the cluster

Peptide	Gene	Start	Entry
IVASQLERCRLGAES	PKP4	61	Q99569
ALESGIEAINCVDLL	C2orf16	621	Q68DN1
VDILGCTGTLEDRAA	BCAR3	611	O75815
EVASLCLEGIRCAIR	ARFGEF1	971	Q9Y6D6
DVSRLDLRIGCIITA	AIMP1	151	Q12904
VIQDLVCDAGAVSSL	CARMIL2	511	Q6F5E8
AVLAGDVGCVSRILA	ASB10	61	Q8WXI3
AVRICDGCIIVVDAV	EFL1	106	Q7Z2Z2
TEISDCTLGIEQLIR	GVINP1	1401	Q7Z2Y8
VSLLFLRVISACADG	FBXW10	621	Q5XX13
GSLCALRAVDESVLL	A2ML1	586	A8K2U0
LSVSADLESRICVVG	ABCF3	511	Q9NUQ8
IVAVCREAALLALEE	SPATA5	836	Q8NB90
EVASLCLEGIRCAIR	ARFGEF2	916	Q9Y6D5
IGVCSFLLAARIVEE	CCNG2	101	Q16589
EDVDGRTALSVAALC	ANKRD50	706	Q9ULJ7
TAVLRSRDLGSVVCD	DEDD2	236	Q8WXF8
ELVALLAARLESCEA	DNHD1	1366	Q96M86
DVSVICSDGADLELR	CD163L1	356	Q9NR16
GSADERLVTCLESLR	DIAPH3	186	Q9NSV4
LLERVEVGLSSCQGD	DHX16	921	O60231
ALCAVLGLRAEGATT	EFCC1	81	Q9HA90
EGCEAISFLLSLIDR	EGLN3	86	Q9H6Z9
TEGLRTLCFAVAEIS	ATP8A1	601	Q9Y2Q0
LCIRSVGLDEQSALE	ADAMTS7	906	Q9UKP4
GRVTECLSLDKLEAA	ABCA7	401	Q8IZY2
RTAVLVAVDDELCGL	ATP7A	1211	Q04656
GICEENAIALLSAAV	RCBTB2	486	O95199
LACEIGSSNAVEALI	RAI14	191	Q9P0K7
LVVASVGDSRAILCR	PPM1K	201	Q8N3J5
RGLCESVVEADLVEA	HNRNPLL	81	Q8WVV9
ADLSALVREASICAL	NVL	791	O15381
VSLLFLRVISACADG	FBXW10B	621	O95170
SVELVGSCATLVTER	PRUNE1	141	Q86TP1
EVRLTLEGCSIDADI	PSTPIP1	251	O43586
VLDDRELLLLTGTCV	PASK	791	Q96RG2
SGEVDLRECVVALSV	LPCAT1	396	Q8NF37
ALRAEGFLCDVTLET	KLHL34	21	Q8N239
DLAEGRSAVVDSVCL	GNB1L	96	Q9BYB4
LRGCELVDLADEVAS	MAVS	76	Q7Z434
ATEGVIEALCSLLRR	INTS1	176	Q8N201
ATVLSVAGLSAERCL	NTSR2	121	O95665
RASECEEIASLLISG	NLRP11	731	P59045
VLLCDRASSGASAVE	JAG2	1011	Q9Y219
EGACADIALVRLERS	PRSS22	136	Q9GZN4
FESRSISIGELALCI	FSIP2	3546	Q5CZC0
AALITAVACRIREAG	HK2	901	P52789
ACVLELEERLSTQEG	KIFC1	211	Q9BW19
LEVAAGEAADLSCRV	CD1A	266	P06126
VCIARLRTAGTICLE	GSPT2	581	Q8IYD1
CLAEAVADTLGVVCR	PCNX2	2101	A6NKB5
AVVTDAARCTSLGIE	GGT7	141	Q9UJ14
VRKICSALDGVETLA	PIK3C2A	581	O00443
GRISALTALRTCELA	PRF1	231	P14222
ENLLVTGAVDCSLRG	PEX7	211	O00628
CKGELERALSAVIAT	GOLGA8Q	176	H3BV12
IRVSELSLCDLAGSE	KIF20B	371	Q96Q89
IDGVDICSIGLEDLR	ABCC11	1201	Q96J66
VVEDGSDCLAAVLRT	MACF1	371	O94854
VASDVALLCGLRAQV	LCT	436	P09848
TCTLLREDFGLSIDI	METTL16	56	Q86W50
TLRILTLEECGIVDS	LRRC14B	361	A6NHZ5
GQRACLAEAITLVES	MMAA	96	Q8IVH4
LRACEAITVGKVDLS	GNL1	291	P36915
VLAELRRCGLTDSET	MUC5AC	471	P98088
VACLVGAGLRLSASD	MSLNL	161	Q96KJ4
TTLCLIAAEAGLSEE	HOPX	31	Q9BPY8
GLSARCRVLVEVLDT	PCDHB10	326	Q9UN67
VAITLVSDGTRCLLA	NUDT13	201	Q86X67
LISDIDGDGCRELVV	ITFG2	131	Q969R8
GAVETRLAAEILCQG	IRGC	146	Q6NXR0
DECGLALGRLASIVE	ALDH18A1	86	P54886
LSAEERGTLALQCEV	OBSCN	2656	Q5VST9
EATEGATAVLRCELS	OBSCN	3636	Q5VST9
VGDALRLECVVASKA	OBSCN	4911	Q5VST9
LLRCSVGAIRIEAAS	OXNAD1	11	Q96HP4
AIILCIQDGSVDAER	OPA1	431	O60313
LTREGDALELTCEAI	CADM1	256	Q9BY67
LCAQILSERVEVSGD	APBB3	246	O95704
ALEGRIVLTVLVSDC	CDHR2	656	Q9BYE9
TLGDCDVIQALDLSV	FKBP8	146	Q14318
VLELICTRESGAVFE	HECTD1	126	Q9ULT8
LLLSAAVCRAEAGLE	FKBP11	16	Q9NYL4
DVRVSVKALALSCVG	HTT	706	P42858
GEEVLALLITARCVV	HYDIN	681	Q4G0P3
ILGISVEFLCSLRSD	HEATR5A	1556	Q86XA9
ENISDDVIVGRCLAI	KDM1A	716	O60341
LLSAEVSGGDRLDCV	GFRA1	16	P56159
TLALAAGALCREARA	DUSP1	101	P28562
GILTRCVDDAAIVLG	QRSL1	231	Q9H0R6
VLLLVSCDLGFVRAD	FNDC4	31	Q9H6D8
LVISSGCATRLFEAL	EXTL3	441	O43909
AATCVSAARGEVNLL	EPHA8	21	P29322
IGVQAEALLRCSDII	GEMIN7	111	Q9H840
ASVRILRAAAACDLL	GPR143	66	P51810
ILLTAEELSNCRDIA	CPNE9	136	Q8IYJ1
LLGSFEDVLIRASAC	CRACR2B	171	Q8N4Y2
VDCLEELGIAAVSQR	FHOD3	286	Q2V2M9
LACLVALALARETIE	CSN2	6	P05814
VLGNACVVAAIALER	HTR1A	51	P08908
AEVITCDVLLVCIGR	DLD	301	P09622
GVEENTLIASLCDLL	DENND5A	786	Q6IQ26
LLAAAGRDVAACLEL	IFNL4	111	K9M1U5
LEDCVLLATDVAARG	DDX24	636	Q9GZR7
ALRTLASICCVEEGV	INSC	301	Q1MX18
VEILEGRTECVLSNL	EPOR	196	P19235
VEQRLRTTIACSLGE	HAUS6	916	Q7Z4H7
LAIASLLLDTGACEV	KANK3	636	Q6NY19
VCVLGRESLDDLTNL	IDE	256	P14735
VKGDSVRACASLVVL	ENDOV	56	Q8N8Q3
LAVCVDTAILEDAGA	EME2	76	A4GXA9
CALSERELAALVQGT	FIGNL2	576	A6NMB9
LCTLIVSAAADSAVR	ELP2	126	Q6IA86
ACTGIENIDEAITLL	FAF1	16	Q9UNN5
QEDSGLCVLARLSEI	EFHD2	166	Q96C19
LATGAACRLVEAVLS	HDAC6	581	Q9UBN7
ACRLVEAVLSGEVLN	HDAC6	586	Q9UBN7
CKGELERALSAVIAT	GOLGA8R	176	I6L899
ILRLGDLDIESQTCA	DCBLD1	81	Q8N8Z6
VICSKGADLSLRLVD	CD163	256	Q86VB7
GADLSLRLVDGVTEC	CD163	261	Q86VB7
TASGDVCLEALRLEE	FMN2	716	Q9NZ56
GLVACVSAESRAELT	SDC2	11	P34741
AILAGLAVCVLTETR	SLC22A20P	496	A6NK97
ACGAVLLTELLERAA	SLC15A4	36	Q8N697
TLEKDLVSACDLLGV	MAU2	156	Q9Y6X3
RVELLGETSIAECLT	DDB1	301	Q16531
LEVVLADGTVLDCLT	D2HGDH	226	Q8N465
TAIVQTRADCSVLGL	PRR14L	1806	Q5THK1
LRLACADTAINELVT	OR10G6	206	Q8NH81
REGAVAALRACLILT	MTOR	206	P42345
EIRELAICTVGRLSS	MTOR	706	P42345
VVANCRALSEALTEL	SHMT1	331	P34896
LREACETVGATLETL	MAP3K5	116	Q99683
DLDVVRRIICSAGLS	NTMT1	186	Q9BV86
RRIICSAGLSLLAEE	NTMT1	191	Q9BV86
TLDCVEISLGRVFAS	PIF1	561	Q9H611
TIEASIDAVIARACA	TAF3	386	Q5VWG9
CEILETAEEGTRVLN	TDRD6	2046	O60522
VEAVLNTDRSLVCDG	TRPC4AP	496	Q8TEL6
VEEALSLQDGCRAIL	SYNE1	4706	Q8NF91
CRAILDEVAGLGEAV	SYNE1	4716	Q8NF91
SLLDLVVFGRACALS	SDHA	456	P31040
TIEDDLVSALVRSGC	PUS1	111	Q9Y606
CLASGTAISELIIED	RIF1	2126	Q5UIP0
CARAGLLSVVVDTLS	GPAM	326	Q9HCL2
GEGCIALRLEATETQ	INPP5D	816	Q92835
VLEGQSLRLVCAVDS	SIGLEC7	266	Q9Y286
TGLILVTAALELCEE	ST8SIA5	301	O15466
LTGVVLISLALCADA	SLC35B3	226	Q9H1N7
GSGACLDLQVIDTVR	SLC9A5	576	Q14940
VATRGLCAIAQAESL	RPS3	91	P23396
LACETAGVIRISDDS	SBNO2	641	Q9Y2G9
AINVLGEASVDCRLE	MYBPH	456	Q13203
LELAVCVGTVLGESA	WDR17	986	Q8IZU2
LLRSVGDTLTVLVCD	SCRIB	1176	Q14160
TEALQSRLGADVCAV	PMVK	26	Q15126
CSLLLTATDDGAIRV	RPTOR	1081	Q8N122
ASAELLERDLVCGSK	SVOPL	301	Q8N434
LSVVAKLLSCGADIE	ANKRD30BL	151	A7E2S9
LSLACSGGRQEVVDL	ANKHD1	1126	Q8IWZ3
EARLSAGCVEERVSL	ACVR2B	466	Q13705
ATADDTEAELIRGIC	NCAPD2	986	Q15021
EARLACESEGGVLLS	CHODL	56	Q9H9P2
VLEADSAIRAAGIKC	C11orf68	226	Q9H3H3
AVATLQTLDLEDCGI	PRAMEF7	346	Q5VXH5
SLDENGTRVITEVLC	RNF213	2606	Q63HN8
RGLAQADGTLITCVD	WDR74	91	Q6RFH5
LVTCATEVGVRALVS	ZSWIM5	891	Q9P217
VTLCLTEAVTVADGD	ZNF143	26	P52747
FEAAVLAGLLTECRD	TNFAIP8L2	111	Q6P589
VIELLNVCEDLAGST	ZNF618	661	Q5T7W0
ELFRALGCSELISSI	RORC	386	P51449
RASCEAVLTVLEVGD	SPEG	116	Q15772
VLLDNVGCAGTEARL	SSC4D	406	Q8WTU2
TSIDAISLECERVLG	MVK	266	Q03426
LSAVVSQAECREGEL	PLEKHG4B	501	Q96PX9
DIVSCLIDLDDGTLS	RNF123	196	Q5XPI4
NVELALTSDGRTIVC	MRPL42	46	Q9Y6G3
ALACRERLAGVEEVS	SPOCD1	146	Q6ZMY3
ELVIKAEGLARSSLC	ZNF398	261	Q8TD17
DGLVACVAQLIRIAD	TRPC5OS	11	A6NMA1
ILCNLTVEAVGADSA	TRIL	586	Q7L0X0
SCDTDALVEVLLRSG	SEMA5B	831	Q9P283
ILVCGSECAIDRLRS	PKHD1L1	2031	Q86WI1
AVTARLCAGVQADTL	TTLL3	481	Q9Y4R7
LCAGVQADTLRVVID	TTLL3	486	Q9Y4R7
TELLDLSLVKDARCG	PLCB1	61	Q9NQ66
ISVRAEVLTTFALCG	SLC28A1	526	O00337
EGSSDSVVLERLCAA	MYO18B	1046	Q8IUG5
GDEAVVRCTLSANLV	SNRNP200	231	O75643
EDTAAVLGVIIAATC	SLC30A9	396	Q6PML9
GACVAALVALLAAVR	PIGO	671	Q8TEQ8
CTLDTTAGEVAARLL	PHLPP1	221	O60346
ILGCTGSAEERAALL	SH2D3C	651	Q8N5H7
LRVASLSCAGEVLVD	TRMT12	226	Q53H54
ALLCAVTELGEVEGR	ZNF407	1991	Q9C0G0
RSGVSRAAVVCLSDL	TOGARAM1	1311	Q9Y4F4
NGLETAEGLDCVRTI	TUT7	1066	Q5VYS8
CISAVLLTDDGATIV	WDR7	21	Q9Y4E6
AVLVNGTECLLARVS	MST1R	716	Q04912
LIAADLSTAKGDVIC	TANGO2	121	Q6ICL3
VLVLSGADGEQTRLC	ZNF628	936	Q5EBL2
RSDGILCDITLIAEE	KLHL32	36	Q96NJ5
RILTDVSICAGAREI	KLHL38	31	Q2WGJ6
LRACGVLETIRISAA	MYO5A	681	Q9Y4I1
LAVDASRARCTVGEI	MMUT	551	P22033
LEAAAAELAGVEICL	N6AMT1	36	Q9Y5N5
DVEEAVSCLSIGVLD	MYO9B	506	Q13459
GLLSLEIRRCAIEDS	MYOM3	211	Q5VTT5