Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ig	GP6 FLT3 MYOM1 CXADR	7.83e-04	190	41	4	PF00047
Domain	Immunoglobulin	GP6 FLT3 MYOM1 CXADR	7.83e-04	190	41	4	IPR013151
Domain	IG	GP6 FLT3 NCR1 MYOM1 CXADR	2.18e-03	421	41	5	SM00409
Domain	Ig_sub	GP6 FLT3 NCR1 MYOM1 CXADR	2.18e-03	421	41	5	IPR003599
Domain	-	GP6 SNED1 FLT3 NCR1 MYOM1 CXADR	3.05e-03	663	41	6	2.60.40.10
Domain	Ig-like_fold	GP6 SNED1 FLT3 NCR1 MYOM1 CXADR	4.15e-03	706	41	6	IPR013783
Domain	IG_LIKE	GP6 FLT3 NCR1 MYOM1 CXADR	4.23e-03	491	41	5	PS50835
Pubmed	Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.	LPAL2 LPA	4.27e-06	3	42	2	19198611
Pubmed	Functional Variant in the SLC22A3-LPAL2-LPA Gene Cluster Contributes to the Severity of Coronary Artery Disease.	LPAL2 LPA	4.27e-06	3	42	2	27417586
Pubmed	Lack of association between four SNPs in the SLC22A3-LPAL2-LPA gene cluster and coronary artery disease in a Chinese Han population: a case control study.	LPAL2 LPA	4.27e-06	3	42	2	23036009
Pubmed	The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function.	NCR1 BACH2	4.27e-06	3	42	2	36190189
Pubmed	5' control regions of the apolipoprotein(a) gene and members of the related plasminogen gene family.	LPAL2 LPA	4.27e-06	3	42	2	7679504
Pubmed	Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes.	LPAL2 LPA	8.53e-06	4	42	2	21900290
Pubmed	Genetic and clinical correlates of early-outgrowth colony-forming units.	LPAL2 LPA	1.42e-05	5	42	2	21493818
Pubmed	Amino acids important for ligand specificity of the human constitutive androstane receptor.	PPARGC1A CXADR	2.13e-05	6	42	2	15572376
Pubmed	Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha.	PPARGC1A CXADR	3.97e-05	8	42	2	18552123
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	GEMIN4 ARFGEF3 PPARGC1A ATR	7.10e-05	183	42	4	23956138
Pubmed	Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients.	PPARGC1A SLCO1B1 LPA	7.11e-05	66	42	3	20679960
Pubmed	Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.	PPARGC1A MYOM1	7.78e-05	11	42	2	18310078
Pubmed	Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo.	NKTR GPATCH8	7.78e-05	11	42	2	14729963
Pubmed	Auditory ganglion source of Sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cells.	NEFL MYO7A	9.32e-05	12	42	2	23918393
Pubmed	Emx2 and early hair cell development in the mouse inner ear.	NEFL MYO7A	1.10e-04	13	42	2	20152827
Pubmed	Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice.	FAM168A MYO7A	3.86e-04	24	42	2	19706712
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	ANKIB1 GEMIN4 ARFGEF3 GPATCH8	5.50e-04	313	42	4	38270169
Pubmed	A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells.	NEFL STAB1	6.06e-04	30	42	2	31065682
Pubmed	DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal.	NEFL MYOM1	6.06e-04	30	42	2	36460641
Pubmed	Assessment of community efforts to advance network-based prediction of protein-protein interactions.	GEMIN4 KPRP DEFA6 FAM168A SLC30A3	9.39e-04	630	42	5	36949045
Pubmed	Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.	GPR19 BACH2	9.74e-04	38	42	2	23273568
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	FSIP2 SNED1 MYO7A	1.11e-03	168	42	3	30631154
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	NEFL FLT3 MYO7A	1.16e-03	171	42	3	20201926
Interaction	CD40 interactions	GEMIN4 ARFGEF3 TRAF5 ATR SLC30A3	1.42e-05	153	41	5	int:CD40
GeneFamily	Immunoglobulin like domain containing	GP6 FLT3 NCR1 CXADR	2.11e-04	193	28	4	594
CoexpressionAtlas	DevelopingGonad_e11.5_testes and mesonephros_emap-3226_k-means-cluster#2_top-relative-expression-ranked_1000	GAL3ST4 NEFL BACH2 CXADR	2.45e-05	90	40	4	gudmap_developingGonad_e11.5_testes and mesonephros_k2_1000
Disease	lipoprotein A measurement, apolipoprotein A 1 measurement	LPAL2 LPA	3.38e-05	7	38	2	EFO_0004614, EFO_0006925
Disease	vascular dementia (is_marker_for)	NEFL LPA	8.82e-05	11	38	2	DOID:8725 (is_marker_for)
Disease	apolipoprotein A 1 measurement	DEFA6 FLT3 LPAL2 FAM168A IP6K3 LPA STAB1	9.16e-05	848	38	7	EFO_0004614
Disease	triglycerides to total lipids in chylomicrons and extremely large VLDL percentage	LPAL2 LPA	1.68e-04	15	38	2	EFO_0022328
Disease	response to statin, LDL cholesterol change measurement	SLCO1B1 LPA	1.68e-04	15	38	2	EFO_0007804, GO_0036273
Disease	cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	LPAL2 LPA	2.17e-04	17	38	2	EFO_0022232
Disease	Alzheimer's disease (is_marker_for)	PPARGC1A NEFL ATR LPA	3.29e-04	257	38	4	DOID:10652 (is_marker_for)
Disease	free cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	LPAL2 LPA	3.34e-04	21	38	2	EFO_0022277
Disease	cholesteryl esters to total lipids in chylomicrons and extremely large VLDL percentage	LPAL2 LPA	3.34e-04	21	38	2	EFO_0022246
Disease	docosahexaenoic acid to total fatty acids percentage	LPAL2 LPA	3.34e-04	21	38	2	EFO_0022262
Disease	amyotrophic lateral sclerosis (is_marker_for)	PPARGC1A NEFL	6.41e-04	29	38	2	DOID:332 (is_marker_for)
Disease	amyotrophic lateral sclerosis (is_implicated_in)	PPARGC1A NEFL	7.82e-04	32	38	2	DOID:332 (is_implicated_in)
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	LPAL2 LPA	8.83e-04	34	38	2	EFO_0008317, EFO_0008596, EFO_0020944
Disease	chylomicron measurement, triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	LPAL2 LPA	8.83e-04	34	38	2	EFO_0008317, EFO_0008596, EFO_0020947
Disease	non-alcoholic fatty liver disease (implicated_via_orthology)	PPARGC1A PPDPF	9.90e-04	36	38	2	DOID:0080208 (implicated_via_orthology)
Disease	low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	LPAL2 SLCO1B1 LPA	1.01e-03	153	38	3	EFO_0004611, EFO_0020946
Disease	low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	LPAL2 SLCO1B1 LPA	1.01e-03	153	38	3	EFO_0004611, EFO_0020944
Disease	degree of unsaturation measurement	LPAL2 LPA	1.16e-03	39	38	2	EFO_0022261
Disease	aspirin use measurement	LPAL2 LPA	1.16e-03	39	38	2	EFO_0007013
Disease	platelet crit	FLT3 GPATCH8 IP6K3 SLCO1B1 LPA BACH2	1.27e-03	952	38	6	EFO_0007985

Protein segments in the cluster

Peptide	Gene	Start	Entry
RTRTSSSCSSYSYAE	BACH2	516	Q9BYV9
KCYRSNAYTITTSSR	GPR19	351	Q15760
SSSTGGYYRCTRYEV	ANKIB1	556	Q9P2G1
YYRRRLGSTSSNSSC	PPDPF	16	Q9H3Y8
NRTYQASSAAFRYTA	FAM168A	91	Q92567
TTAHRGTYRCFGSYN	NCR1	181	O76036
TCSEDFTYRSYTSAT	FSIP2	561	Q5CZC0
ASSDQSCYSRQRSYS	GPATCH8	876	Q9UKJ3
SCYSRQRSYSDDSYS	GPATCH8	881	Q9UKJ3
TAAHSGTYRCYSFSS	GP6	171	Q9HCN6
AQTYSPSSTCRYRSL	MTSS2	296	Q765P7
YSRSQCSCGSLSSQY	LCA5L	51	O95447
RQFSTYFRYGACHTT	LRGUK	436	Q96M69
RSAFSYYKSTSSAFR	GAL3ST4	166	Q96RP7
SVIRSQSSYRFYSSS	IP6K3	311	Q96PC2
SECSYYSSRISSARS	LRRFIP2	221	Q9Y608
PGSRSSSRSCYYYES	PPARGC1A	591	Q9UBK2
FVSSVARNDTGYYTC	FLT3	316	P36888
YSSRSAYCRSTAVMS	ATR	2451	Q13535
RSCYSTEYSYGTCTV	DEFA6	76	Q01524
YSGTYSCTVRNRVGS	CXADR	206	P78310
DCRTRSYGSRYSESN	ARFGEF3	581	Q5TH69
VTSASNNETYCRSFY	ACKR3	186	P25106
YRGTYSTTVTGRTCQ	LPA	36	P08519
SYRGTYSTTVTGRTC	LPA	491	P08519
YRGTYSTTVTGRTCQ	LPA	606	P08519
SYRGTYSTTVTGRTC	LPA	1061	P08519
GRFSTQCQYQGSYSS	KPRP	176	Q5T749
CSRNFSSRSFGGYLY	KRTAP13-4	6	Q3LI77
RTYSQGDCSYSRTAL	DNAJC30	36	Q96LL9
YRGTYFTTVTGRTCQ	LPAL2	36	Q16609
CRSYGSDSESDRSYS	NKTR	1436	P30414
SSSGYSNSRYSRYHS	SRSF8	191	Q9BRL6
GSCRTYNSTSFSRVY	SLCO1B1	611	Q9Y6L6
YAVTYVSSDGSYRRT	SNED1	941	Q8TER0
VSIFSQSFYTSRCGY	TRAF5	426	O00463
QLSSATFIRYSSTCF	PLET1	21	Q6UQ28
RTFSVYSSSRQQGRY	VPS51	646	Q9UID3
YTEAYSRGRDSFSNS	RBMXL3	886	Q8N7X1
VYRSGFSFSRGCSYT	STAB1	1296	Q9NY15
EASSRLYSRFGFSSC	SLC30A3	351	Q99726
SQYVCRLYRSDSDSS	WWC3	916	Q9ULE0
RSSQGTSYDSYRLCD	GEMIN4	336	P57678
TSYDSYRLCDSLTSF	GEMIN4	341	P57678
ATYFQGTTTHSYTRR	MYO7A	1006	Q13402
SAVYTQGSTAYSSRS	MYOM1	36	P52179
ISSVRSGYSTARSAY	NEFL	26	P07196