| GeneOntologyMolecularFunction | deubiquitinase activity | USP34 USP17L21 USP17L2 USP17L23 USP17L12 USP17L20 USP28 USP17L11 USP17L24 USP17L5 USP17L19 MYSM1 USP17L18 USP17L17 USP42 OTUD7A USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 1.69e-25 | 124 | 113 | 21 | GO:0101005 |
| GeneOntologyMolecularFunction | cysteine-type deubiquitinase activity | USP34 USP17L21 USP17L2 USP17L23 USP17L12 USP17L20 USP28 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP42 OTUD7A USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 1.21e-24 | 114 | 113 | 20 | GO:0004843 |
| GeneOntologyMolecularFunction | ubiquitin-like protein peptidase activity | USP34 USP17L21 USP17L2 USP17L23 USP17L12 USP17L20 USP28 USP17L11 USP17L24 USP17L5 USP17L19 MYSM1 USP17L18 USP17L17 USP42 OTUD7A USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 1.55e-24 | 137 | 113 | 21 | GO:0019783 |
| GeneOntologyMolecularFunction | cysteine-type peptidase activity | USP34 USP17L21 USP17L2 USP17L23 USP17L12 USP17L20 USP28 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP42 OTUD7A USP17L6P USP17L22 ESPL1 USP17L15 USP17L8 USP17L13 | 2.35e-21 | 192 | 113 | 21 | GO:0008234 |
| GeneOntologyMolecularFunction | peptidase activity | USP34 USP17L21 USP17L2 USP17L23 USP17L12 USP17L20 USP28 USP17L11 USP17L24 USP17L5 USP17L19 MYSM1 USP17L18 USP17L17 USP42 LMLN OTUD7A USP17L6P USP17L22 ESPL1 USP17L15 USP17L8 USP17L13 | 1.77e-12 | 654 | 113 | 23 | GO:0008233 |
| GeneOntologyMolecularFunction | transmembrane receptor protein kinase activity | CRIM1 BMPR1A LTBP1 KIT EPHA1 | 1.21e-04 | 85 | 113 | 5 | GO:0019199 |
| GeneOntologyMolecularFunction | telomerase RNA binding | SMG5 TEP1 PARN | 3.71e-04 | 25 | 113 | 3 | GO:0070034 |
| GeneOntologyMolecularFunction | structural constituent of nuclear pore | NUP88 NUP205 NDC1 | 3.71e-04 | 25 | 113 | 3 | GO:0017056 |
| GeneOntologyBiologicalProcess | protein deubiquitination | USP34 USP17L21 ITCH USP17L2 USP17L12 USP17L20 USP28 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP42 OTUD7A USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 2.11e-24 | 125 | 109 | 20 | GO:0016579 |
| GeneOntologyBiologicalProcess | protein modification by small protein removal | USP34 USP17L21 ITCH USP17L2 USP17L12 USP17L20 USP28 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP42 OTUD7A USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 4.12e-23 | 144 | 109 | 20 | GO:0070646 |
| GeneOntologyBiologicalProcess | protein modification by small protein conjugation or removal | USP34 USP17L21 ITCH USP17L2 USP17L12 USP17L20 USP28 USP17L11 WWP2 USP17L24 USP17L5 USP17L19 TRIM3 USP17L18 USP17L17 USP42 ASB16 OTUD7A USP17L6P USP17L22 USP17L15 USP17L8 PINK1 USP17L13 | 4.16e-10 | 1009 | 109 | 24 | GO:0070647 |
| GeneOntologyBiologicalProcess | post-translational protein modification | USP34 USP17L21 ITCH USP17L2 USP17L12 USP17L20 USP28 USP17L11 WWP2 USP17L24 USP17L5 USP17L19 TRIM3 USP17L18 USP17L17 USP42 ASB16 OTUD7A USP17L6P USP17L22 USP17L15 USP17L8 PINK1 USP17L13 | 1.45e-09 | 1074 | 109 | 24 | GO:0043687 |
| GeneOntologyBiologicalProcess | protein deubiquitination involved in ubiquitin-dependent protein catabolic process | USP28 USP17L24 OTUD7A USP17L6P | 5.08e-08 | 8 | 109 | 4 | GO:0071947 |
| GeneOntologyBiologicalProcess | telomere maintenance via telomere lengthening | CTC1 SMG5 DCLRE1B TEP1 PARN | 1.16e-04 | 90 | 109 | 5 | GO:0010833 |
| HumanPheno | Esophageal stenosis | CTC1 LAMC2 DCLRE1B PARN | 4.06e-05 | 33 | 31 | 4 | HP:0010450 |
| HumanPheno | Bone marrow hypocellularity | CTC1 DCLRE1B MYSM1 SLC30A7 PARN | 4.74e-05 | 68 | 31 | 5 | HP:0005528 |
| MousePheno | increased trophectoderm apoptosis | USP17L2 USP17L15 USP17L13 | 9.53e-06 | 8 | 79 | 3 | MP:0012119 |
| Domain | HABP4_PAI-RBP1 | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13 | 1.33e-24 | 16 | 108 | 12 | PF04774 |
| Domain | HABP4_PAIRBP1-bd | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13 | 1.33e-24 | 16 | 108 | 12 | IPR006861 |
| Domain | USP_CS | USP34 USP17L21 USP17L2 USP17L12 USP17L20 USP28 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP42 USP17L22 USP17L8 USP17L13 | 3.31e-22 | 66 | 108 | 16 | IPR018200 |
| Domain | USP_1 | USP34 USP17L21 USP17L2 USP17L12 USP17L20 USP28 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP42 USP17L22 USP17L8 USP17L13 | 9.43e-22 | 70 | 108 | 16 | PS00972 |
| Domain | UCH | USP34 USP17L21 USP17L2 USP17L12 USP17L20 USP28 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP42 USP17L22 USP17L8 USP17L13 | 1.21e-21 | 71 | 108 | 16 | PF00443 |
| Domain | USP_2 | USP34 USP17L21 USP17L2 USP17L12 USP17L20 USP28 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP42 USP17L22 USP17L8 USP17L13 | 1.21e-21 | 71 | 108 | 16 | PS00973 |
| Domain | USP_3 | USP34 USP17L21 USP17L2 USP17L12 USP17L20 USP28 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP42 USP17L22 USP17L8 USP17L13 | 1.55e-21 | 72 | 108 | 16 | PS50235 |
| Domain | USP_dom | USP34 USP17L21 USP17L2 USP17L12 USP17L20 USP28 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP42 USP17L22 USP17L8 USP17L13 | 1.55e-21 | 72 | 108 | 16 | IPR028889 |
| Domain | Peptidase_C19_UCH | USP34 USP17L21 USP17L2 USP17L12 USP17L20 USP28 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP42 USP17L22 USP17L8 USP17L13 | 1.55e-21 | 72 | 108 | 16 | IPR001394 |
| Domain | - | ITCH WWP2 PLA2G4E ESYT3 PIK3CB MCTP2 WWC1 | 2.43e-05 | 148 | 108 | 7 | 2.60.40.150 |
| Domain | C2_dom | ITCH WWP2 PLA2G4E ESYT3 PIK3CB MCTP2 WWC1 | 4.69e-05 | 164 | 108 | 7 | IPR000008 |
| Domain | C2 | ITCH WWP2 PLA2G4E ESYT3 MCTP2 WWC1 | 1.13e-04 | 131 | 108 | 6 | PF00168 |
| Domain | WW | ITCH WWP2 ARHGAP39 WWC1 | 1.56e-04 | 47 | 108 | 4 | PF00397 |
| Domain | WW | ITCH WWP2 ARHGAP39 WWC1 | 1.69e-04 | 48 | 108 | 4 | SM00456 |
| Domain | C2 | ITCH WWP2 PLA2G4E ESYT3 MCTP2 WWC1 | 1.76e-04 | 142 | 108 | 6 | PS50004 |
| Domain | WW_DOMAIN_2 | ITCH WWP2 ARHGAP39 WWC1 | 2.14e-04 | 51 | 108 | 4 | PS50020 |
| Domain | WW_DOMAIN_1 | ITCH WWP2 ARHGAP39 WWC1 | 2.14e-04 | 51 | 108 | 4 | PS01159 |
| Domain | WW_dom | ITCH WWP2 ARHGAP39 WWC1 | 2.31e-04 | 52 | 108 | 4 | IPR001202 |
| Domain | SWIRM | MYSM1 SMARCC1 | 4.89e-04 | 6 | 108 | 2 | PS50934 |
| Domain | SWIRM | MYSM1 SMARCC1 | 4.89e-04 | 6 | 108 | 2 | PF04433 |
| Domain | SWIRM | MYSM1 SMARCC1 | 4.89e-04 | 6 | 108 | 2 | IPR007526 |
| Domain | Leu-rich_rpt | LRRC24 NLRX1 LRRC69 PXDN CEP78 LRCH4 LRRN4 | 1.00e-03 | 271 | 108 | 7 | IPR001611 |
| Domain | C2 | ITCH WWP2 PLA2G4E ESYT3 MCTP2 | 1.20e-03 | 137 | 108 | 5 | SM00239 |
| Domain | Keratin_I | KRT31 KRT33B KRT34 | 2.10e-03 | 44 | 108 | 3 | IPR002957 |
| Domain | Growth_fac_rcpt_ | CRIM1 LAMC2 HMCN1 LTBP1 EPHA1 | 2.13e-03 | 156 | 108 | 5 | IPR009030 |
| Domain | IGc2 | LRRC24 PXDN PTPRF HMCN1 SIGLEC11 KIT | 2.45e-03 | 235 | 108 | 6 | SM00408 |
| Domain | Ig_sub2 | LRRC24 PXDN PTPRF HMCN1 SIGLEC11 KIT | 2.45e-03 | 235 | 108 | 6 | IPR003598 |
| Domain | SSD | NPC1L1 DISP2 | 2.48e-03 | 13 | 108 | 2 | IPR000731 |
| Domain | SSD | NPC1L1 DISP2 | 2.48e-03 | 13 | 108 | 2 | PS50156 |
| Domain | - | LRRC24 NLRX1 LRRC69 PXDN CEP78 LRCH4 LRRN4 | 2.63e-03 | 321 | 108 | 7 | 3.80.10.10 |
| Domain | L_dom-like | LRRC24 NLRX1 LRRC69 PXDN CEP78 LRCH4 LRRN4 | 2.97e-03 | 328 | 108 | 7 | IPR032675 |
| Domain | LRR_8 | LRRC24 LRRC69 PXDN LRCH4 LRRN4 | 3.17e-03 | 171 | 108 | 5 | PF13855 |
| Domain | Leu-rich_rpt_typical-subtyp | LRRC24 LRRC69 PXDN LRCH4 LRRN4 | 3.67e-03 | 177 | 108 | 5 | IPR003591 |
| Domain | LRR_TYP | LRRC24 LRRC69 PXDN LRCH4 LRRN4 | 3.67e-03 | 177 | 108 | 5 | SM00369 |
| Domain | Ig_I-set | LRRC24 PXDN PTPRF HMCN1 SIGLEC11 | 4.95e-03 | 190 | 108 | 5 | IPR013098 |
| Domain | I-set | LRRC24 PXDN PTPRF HMCN1 SIGLEC11 | 4.95e-03 | 190 | 108 | 5 | PF07679 |
| Domain | - | LRRC24 TRIM3 PXDN PTPRF HMCN1 ASTN2 SIGLEC11 LRRN4 KIT EPHA1 | 5.06e-03 | 663 | 108 | 10 | 2.60.40.10 |
| Pathway | REACTOME_RAS_PROCESSING | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 1.57e-21 | 45 | 80 | 14 | MM15671 |
| Pathway | REACTOME_DEUBIQUITINATION | USP34 USP17L21 USP17L2 USP17L12 USP17L20 USP28 USP17L11 USP17L5 USP17L19 MYSM1 USP17L18 USP17L17 USP42 OTUD7A USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 2.85e-16 | 262 | 80 | 19 | MM15286 |
| Pathway | REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES | USP34 USP17L21 USP17L2 USP17L12 USP17L20 USP28 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP42 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 4.10e-16 | 191 | 80 | 17 | MM15289 |
| Pathway | REACTOME_DEUBIQUITINATION | USP34 USP17L21 USP17L2 USP17L12 USP17L20 USP28 USP17L11 USP17L24 USP17L5 USP17L19 MYSM1 USP17L18 USP17L17 USP42 OTUD7A USP17L22 USP17L15 USP17L8 USP17L13 | 3.27e-15 | 299 | 80 | 19 | M27574 |
| Pathway | REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES | USP34 USP17L21 USP17L2 USP17L12 USP17L20 USP28 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP42 USP17L22 USP17L15 USP17L8 USP17L13 | 4.77e-15 | 221 | 80 | 17 | M27578 |
| Pathway | REACTOME_MAPK_FAMILY_SIGNALING_CASCADES | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 PIK3CB USP17L6P USP17L22 KIT USP17L15 USP17L8 USP17L13 | 2.26e-11 | 318 | 80 | 16 | MM15278 |
| Pathway | REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION | USP34 USP17L21 USP17L2 USP17L12 USP17L20 USP28 USP17L11 NUP88 USP17L5 USP17L19 MYSM1 NUP205 USP17L18 NDC1 USP17L17 USP42 ASB16 OTUD7A USP17L6P LTBP1 USP17L22 USP17L15 USP17L8 USP17L13 | 4.06e-07 | 1389 | 80 | 24 | MM15307 |
| Pathway | REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION | USP34 USP17L21 USP17L2 USP17L12 USP17L20 USP28 USP17L11 USP17L24 NUP88 USP17L5 USP17L19 MYSM1 NUP205 USP17L18 NDC1 USP17L17 USP42 ASB16 OTUD7A LTBP1 USP17L22 USP17L15 USP17L8 USP17L13 | 1.21e-06 | 1475 | 80 | 24 | M19806 |
| Pubmed | DUB-1, a deubiquitinating enzyme with growth-suppressing activity. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 9.37e-31 | 21 | 115 | 14 | 8622927 |
| Pubmed | DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 9.37e-31 | 21 | 115 | 14 | 14583620 |
| Pubmed | DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 9.37e-31 | 21 | 115 | 14 | 11468161 |
| Pubmed | The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 9.37e-31 | 21 | 115 | 14 | 8756639 |
| Pubmed | Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 9.37e-31 | 21 | 115 | 14 | 12447969 |
| Pubmed | DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 9.37e-31 | 21 | 115 | 14 | 18980247 |
| Pubmed | JAK2 is required for induction of the murine DUB-1 gene. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 2.57e-30 | 22 | 115 | 14 | 9154835 |
| Pubmed | DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 1.57e-29 | 24 | 115 | 14 | 8995226 |
| Pubmed | Cdc25A and Dub3 in a high-stakes balancing act. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 2.36e-29 | 33 | 115 | 15 | 20228807 |
| Pubmed | Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 3.55e-29 | 25 | 115 | 14 | 21115691 |
| Pubmed | The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 4.21e-29 | 34 | 115 | 15 | 20403174 |
| Pubmed | Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 4.21e-29 | 34 | 115 | 15 | 17109758 |
| Pubmed | The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 4.21e-29 | 34 | 115 | 15 | 20388806 |
| Pubmed | DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 4.21e-29 | 34 | 115 | 15 | 14699124 |
| Pubmed | Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 4.21e-29 | 34 | 115 | 15 | 20715989 |
| Pubmed | Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 4.21e-29 | 34 | 115 | 15 | 9806828 |
| Pubmed | The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 4.21e-29 | 34 | 115 | 15 | 20368735 |
| Pubmed | The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 4.21e-29 | 34 | 115 | 15 | 15780755 |
| Pubmed | USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 4.21e-29 | 34 | 115 | 15 | 19188362 |
| Pubmed | Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 4.21e-29 | 34 | 115 | 15 | 11941478 |
| Pubmed | The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 4.21e-29 | 34 | 115 | 15 | 10936051 |
| Pubmed | The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 4.21e-29 | 34 | 115 | 15 | 21448158 |
| Pubmed | Cytokine-regulated protein degradation by the ubiquitination system. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 7.34e-29 | 35 | 115 | 15 | 16611142 |
| Pubmed | Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 7.34e-29 | 35 | 115 | 15 | 21239494 |
| Pubmed | Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 7.68e-29 | 26 | 115 | 14 | 35816173 |
| Pubmed | The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 1.26e-28 | 36 | 115 | 15 | 20147298 |
| Pubmed | Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 2.11e-28 | 37 | 115 | 15 | 20228808 |
| Pubmed | Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 6.12e-28 | 29 | 115 | 14 | 32527007 |
| Pubmed | DUX is a non-essential synchronizer of zygotic genome activation. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 6.99e-24 | 50 | 115 | 14 | 31806660 |
| Pubmed | USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 PLA2G4E USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 7.02e-09 | 674 | 115 | 15 | 37196079 |
| Pubmed | Human and mouse proteases: a comparative genomic approach. | USP34 USP17L2 USP28 USP42 USP17L6P USP17L15 USP17L8 | 1.02e-08 | 81 | 115 | 7 | 12838346 |
| Pubmed | High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency. | USP17L2 USP17L6P USP17L15 USP17L8 | 2.35e-08 | 10 | 115 | 4 | 24207026 |
| Pubmed | Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells. | USP17L2 USP17L6P USP17L15 USP17L8 | 5.50e-08 | 12 | 115 | 4 | 24695638 |
| Pubmed | OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase. | USP17L2 USP28 MYSM1 USP42 OTUD7A | 6.79e-08 | 32 | 115 | 5 | 33669244 |
| Pubmed | ES cell neural differentiation reveals a substantial number of novel ESTs. | USP17L2 USP17L6P USP17L15 USP17L8 | 1.11e-07 | 14 | 115 | 4 | 11793228 |
| Pubmed | Embryonic demise caused by targeted disruption of a cysteine protease Dub-2. | USP17L2 USP17L15 USP17L13 | 1.41e-07 | 4 | 115 | 3 | 22984479 |
| Pubmed | A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220. | USP17L21 USP17L12 USP17L20 USP17L11 USP17L19 USP17L18 USP17L17 | 1.48e-07 | 119 | 115 | 7 | 28625976 |
| Pubmed | CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1. | USP17L2 USP17L6P USP17L15 USP17L8 | 4.23e-07 | 19 | 115 | 4 | 28067227 |
| Pubmed | Whn and mHa3 are components of the genetic hierarchy controlling hair follicle differentiation. | KRT31 KRT33B KRT34 | 6.99e-07 | 6 | 115 | 3 | 10559501 |
| Pubmed | Characterization of a 190-kilobase pair domain of human type I hair keratin genes. | KRT31 KRT33B KRT34 | 2.92e-06 | 9 | 115 | 3 | 9756910 |
| Pubmed | Human hair keratins. | KRT31 KRT33B KRT34 | 2.92e-06 | 9 | 115 | 3 | 7686952 |
| Pubmed | The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. | KRT31 KRT33B KRT34 | 4.16e-06 | 10 | 115 | 3 | 10391933 |
| Pubmed | USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells. | USP28 MAST1 | 1.08e-05 | 2 | 115 | 2 | 38498222 |
| Pubmed | Wwp2 targets SRG3, a scaffold protein of the SWI/SNF-like BAF complex, for ubiquitination and degradation. | WWP2 SMARCC1 | 1.08e-05 | 2 | 115 | 2 | 24365151 |
| Pubmed | Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility. | PIK3CB KIT | 1.08e-05 | 2 | 115 | 2 | 20053680 |
| Pubmed | Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. | KRT31 KRT33B KRT34 OAS3 SUPT20HL2 | 1.74e-05 | 96 | 115 | 5 | 23580065 |
| Pubmed | Wwp2-mediated ubiquitination of the RNA polymerase II large subunit in mouse embryonic pluripotent stem cells. | WWP2 SMARCC1 | 3.24e-05 | 3 | 115 | 2 | 17526739 |
| Pubmed | Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner. | ITCH WWP2 | 3.24e-05 | 3 | 115 | 2 | 19997087 |
| Pubmed | Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. | ITCH WWP2 | 3.24e-05 | 3 | 115 | 2 | 12450395 |
| Pubmed | The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR. | ITCH WWP2 | 3.24e-05 | 3 | 115 | 2 | 29925997 |
| Pubmed | Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis. | HRH1 KIT | 3.24e-05 | 3 | 115 | 2 | 23922690 |
| Pubmed | The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5. | SUPT20HL1 SUPT20HL2 | 3.24e-05 | 3 | 115 | 2 | 24220028 |
| Pubmed | Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. | HRH1 KIT | 3.24e-05 | 3 | 115 | 2 | 29812984 |
| Pubmed | Chemical kindling induced by pentylenetetrazol in histamine H(1) receptor gene knockout mice (H(1)KO), histidine decarboxylase-deficient mice (HDC(-/-)) and mast cell-deficient W/W(v) mice. | HRH1 KIT | 3.24e-05 | 3 | 115 | 2 | 12644274 |
| Pubmed | USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling. | ITCH WWP2 BMPR1A | 5.18e-05 | 22 | 115 | 3 | 24850914 |
| Pubmed | Nedd4-interacting protein 2, a short half-life membrane protein degraded in lysosomes, negatively controls down-regulation of connexin43. | ITCH WWP2 | 6.48e-05 | 4 | 115 | 2 | 20522958 |
| Pubmed | Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled. | ITCH WWP2 | 6.48e-05 | 4 | 115 | 2 | 26701932 |
| Pubmed | Evaluation of the ARMD1 locus on 1q25-31 in patients with age-related maculopathy: genetic variation in laminin genes and in exon 104 of HEMICENTIN-1. | LAMC2 HMCN1 | 6.48e-05 | 4 | 115 | 2 | 15370542 |
| Pubmed | E3 ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation. | WWP2 LTBP1 | 1.08e-04 | 5 | 115 | 2 | 23479606 |
| Pubmed | Characterisation of Crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern. | CRIM1 KIT | 1.08e-04 | 5 | 115 | 2 | 11084657 |
| Pubmed | A Tunable Brake for HECT Ubiquitin Ligases. | ITCH WWP2 | 1.08e-04 | 5 | 115 | 2 | 28475870 |
| Pubmed | Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. | LAMC2 KIT EPHA1 | 1.09e-04 | 28 | 115 | 3 | 18593464 |
| Pubmed | Integrated structural analysis of the human nuclear pore complex scaffold. | NUP88 NUP205 NDC1 | 1.34e-04 | 30 | 115 | 3 | 24315095 |
| Pubmed | The Structure Inventory of the Nuclear Pore Complex. | NUP88 NUP205 NDC1 | 1.34e-04 | 30 | 115 | 3 | 27016207 |
| Pubmed | N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking. | ITCH WWP2 | 1.61e-04 | 6 | 115 | 2 | 15252135 |
| Pubmed | Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice. | ITCH WWP2 | 1.61e-04 | 6 | 115 | 2 | 37156795 |
| Pubmed | Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. | ITCH WWP2 | 1.61e-04 | 6 | 115 | 2 | 9647693 |
| Pubmed | N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. | ITCH WWP2 | 1.61e-04 | 6 | 115 | 2 | 11748237 |
| Pubmed | Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis. | ITCH WWP2 | 2.25e-04 | 7 | 115 | 2 | 31845480 |
| Pubmed | Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases. | ITCH WWP2 | 2.25e-04 | 7 | 115 | 2 | 11046148 |
| Pubmed | Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming. | ITCH WWP2 | 2.25e-04 | 7 | 115 | 2 | 23644597 |
| Pubmed | Mast cell-derived histamine mediates cystitis pain. | HRH1 KIT | 2.25e-04 | 7 | 115 | 2 | 18461160 |
| Pubmed | The genetic architecture of economic and political preferences. | DCBLD1 ASTN2 PCM1 | 2.52e-04 | 37 | 115 | 3 | 22566634 |
| Pubmed | Crosstalk between Nodal/activin and MAPK p38 signaling is essential for anterior-posterior axis specification. | SUPT20HL1 SUPT20HL2 | 3.00e-04 | 8 | 115 | 2 | 21802298 |
| Pubmed | A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover. | ITCH WWP2 | 3.00e-04 | 8 | 115 | 2 | 19307600 |
| Pubmed | The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel. | ITCH WWP2 | 3.00e-04 | 8 | 115 | 2 | 11244092 |
| Pubmed | Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. | ITCH WWP2 | 3.00e-04 | 8 | 115 | 2 | 17719543 |
| Pubmed | Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases. | ITCH WWP2 | 3.00e-04 | 8 | 115 | 2 | 31578285 |
| Pubmed | Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. | USP34 ITCH TTC28 OAS3 TEP1 BMPR1A ZFHX4 CBY2 MEPCE SMARCC1 PCM1 WWC1 | 3.33e-04 | 1116 | 115 | 12 | 31753913 |
| Pubmed | Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. | ITCH LRRC24 USP28 ARHGAP39 TRIM3 KCNA4 NGEF SMARCC1 TJAP1 PARN PCM1 | 3.60e-04 | 963 | 115 | 11 | 28671696 |
| Pubmed | Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis. | KIAA0586 PCM1 | 3.84e-04 | 9 | 115 | 2 | 27146717 |
| Pubmed | Identification and validation of selective deubiquitinase inhibitors. | USP17L2 USP28 | 3.84e-04 | 9 | 115 | 2 | 34129829 |
| Pubmed | Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog. | ITCH WWP2 | 4.79e-04 | 10 | 115 | 2 | 25092867 |
| Pubmed | Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. | CCDC116 PCM1 | 4.79e-04 | 10 | 115 | 2 | 25074808 |
| Pubmed | TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry. | KIT TANGO6 | 4.79e-04 | 10 | 115 | 2 | 38490996 |
| Pubmed | Characterization of ubiquitination dependent dynamics in growth factor receptor signaling by quantitative proteomics. | WWP2 PCM1 | 4.79e-04 | 10 | 115 | 2 | 21956701 |
| Pubmed | Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. | USP34 TSHZ3 TTC28 NUP88 ZFHX4 PCM1 TANGO6 | 4.96e-04 | 418 | 115 | 7 | 34709266 |
| Pubmed | Defining the human deubiquitinating enzyme interaction landscape. | ITCH USP17L2 TTC28 KRT31 KRT33B KRT34 USP28 NUP88 NUP205 USP42 MEPCE | 5.14e-04 | 1005 | 115 | 11 | 19615732 |
| Pubmed | Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation. | WWP2 BMPR1A | 5.85e-04 | 11 | 115 | 2 | 35842443 |
| Pubmed | ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer. | ITCH WWP2 | 5.85e-04 | 11 | 115 | 2 | 34927784 |
| Pubmed | Mapping of six dominant cataract genes in the mouse. | CRYGD KIT | 5.85e-04 | 11 | 115 | 2 | 8034315 |
| Pubmed | Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1. | ITCH WWP2 | 5.85e-04 | 11 | 115 | 2 | 17996703 |
| Pubmed | Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding. | ITCH WWP2 | 5.85e-04 | 11 | 115 | 2 | 21191027 |
| Pubmed | Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. | SUPT20HL1 SUPT20HL2 | 5.85e-04 | 11 | 115 | 2 | 24051374 |
| Pubmed | USP11 augments TGFβ signalling by deubiquitylating ALK5. | ITCH WWP2 | 5.85e-04 | 11 | 115 | 2 | 22773947 |
| Pubmed | Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein. | ITCH WWP2 | 5.85e-04 | 11 | 115 | 2 | 25963657 |
| Pubmed | Comparative interactome analysis of α-arrestin families in human and Drosophila. | ITCH WWP2 TRIM3 BMPR1A PTPRF CEP78 | 6.27e-04 | 313 | 115 | 6 | 38270169 |
| Pubmed | Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. | OAS3 PTPRF PIK3CB PCM1 | 7.38e-04 | 122 | 115 | 4 | 31615875 |
| Pubmed | Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl. | CRYGD ROM1 WWC1 | 7.73e-04 | 54 | 115 | 3 | 15163632 |
| Pubmed | Ring Finger Protein 11 acts on ligand-activated EGFR via the direct interaction with the UIM region of ANKRD13 protein family. | ITCH WWP2 SLC27A2 | 8.15e-04 | 55 | 115 | 3 | 31985874 |
| Cytoband | 4p16.1 | USP17L21 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13 | 1.83e-22 | 79 | 115 | 14 | 4p16.1 |
| Cytoband | Ensembl 112 genes in cytogenetic band chr4p16 | USP17L21 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13 | 5.85e-16 | 222 | 115 | 14 | chr4p16 |
| GeneFamily | Ubiquitin specific peptidases | USP34 USP17L2 USP28 USP42 | 5.47e-05 | 56 | 67 | 4 | 366 |
| GeneFamily | C2 and WW domain containing | WWP2 WWC1 | 8.08e-05 | 4 | 67 | 2 | 838 |
| GeneFamily | Keratins, type I | KRT31 KRT33B KRT34 | 1.49e-04 | 28 | 67 | 3 | 608 |
| GeneFamily | Nucleoporins | NUP88 NUP205 NDC1 | 2.23e-04 | 32 | 67 | 3 | 1051 |
| GeneFamily | Blood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing | LRRC24 PXDN PTPRF HMCN1 SIGLEC11 | 3.26e-04 | 161 | 67 | 5 | 593 |
| GeneFamily | Zinc fingers C2H2-type|ZF class homeoboxes and pseudogenes | TSHZ3 ZFHX4 | 1.38e-03 | 15 | 67 | 2 | 529 |
| GeneFamily | Fibronectin type III domain containing | PTPRF ASTN2 LRRN4 EPHA1 | 2.94e-03 | 160 | 67 | 4 | 555 |
| Coexpression | MADAN_DPPA4_TARGETS | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 RASIP1 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 2.13e-20 | 86 | 113 | 15 | MM1312 |
| Coexpression | GERY_CEBP_TARGETS | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 RNASE2 USP17L17 USP17L6P USP17L22 USP17L15 WWC1 USP17L8 USP17L13 | 1.15e-17 | 160 | 113 | 16 | MM1155 |
| Coexpression | GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 5.64e-17 | 112 | 113 | 14 | MM1095 |
| Coexpression | GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 NLRX1 DCBLD1 USP17L5 USP17L19 USP17L18 USP17L17 USP17L6P ROM1 USP17L22 USP17L15 USP17L8 USP17L13 | 2.67e-09 | 647 | 113 | 17 | MM981 |
| Coexpression | MARSON_BOUND_BY_FOXP3_STIMULATED | SUPT20HL1 USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 SUPT20HL2 SMG5 USP17L19 DCLRE1B USP17L18 DDIAS USP17L17 USP17L6P SMARCC1 USP17L22 USP17L15 USP17L8 USP17L13 | 3.08e-08 | 1072 | 113 | 20 | MM1031 |
| Coexpression | GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 NLRX1 DCBLD1 USP17L5 OAS3 USP17L19 ARHGAP39 USP17L18 USP17L17 P2RY6 USP17L6P ROM1 USP17L22 USP17L15 USP17L8 USP17L13 | 2.69e-07 | 1226 | 113 | 20 | MM979 |
| Coexpression | BRUINS_UVC_RESPONSE_LATE | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L5 USP17L19 USP17L18 PXDN USP17L17 USP17L6P ROM1 USP17L22 USP17L15 EPHA1 USP17L8 USP17L13 | 1.48e-05 | 1198 | 113 | 17 | MM1062 |
| ToppCell | droplet-Tongue-Unstain-18m-Epithelial-nan|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation | KRT31 KRT33B KRT34 ARHGAP39 PIP5K1C ESYT3 | 8.43e-07 | 133 | 107 | 6 | f7d0763b5eec2db33044d6850fd57462494038c1 |
| ToppCell | PCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung | CFAP47 SUSD4 PTPRF MCTP2 WWC1 SLC27A2 | 5.36e-06 | 183 | 107 | 6 | c5b10571599dc26476170b54b53f09c23e6b3117 |
| Drug | Diloxanide furoate [3736-81-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A | USP34 LAMC2 TEP1 PIP5K1C SMARCC1 TJAP1 ZC3H7B PCM1 EPHA1 | 2.18e-07 | 197 | 100 | 9 | 5025_DN |
| Disease | primary ovarian insufficiency (implicated_via_orthology) | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP42 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 5.47e-28 | 46 | 112 | 16 | DOID:5426 (implicated_via_orthology) |
| Disease | congenital heart disease (implicated_via_orthology) | USP17L21 USP17L2 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP42 USP17L6P USP17L22 USP17L15 USP17L8 USP17L13 | 9.84e-25 | 69 | 112 | 16 | DOID:1682 (implicated_via_orthology) |
| Disease | Osteoarthritis, Knee | WWP2 LTBP1 | 8.53e-05 | 4 | 112 | 2 | C0409959 |
| Disease | HOYERAAL-HREIDARSSON SYNDROME | DCLRE1B PARN | 6.30e-04 | 10 | 112 | 2 | C1846142 |
| Disease | chronic musculoskeletal pain | WWP2 SHISAL2A | 9.19e-04 | 12 | 112 | 2 | EFO_0022195 |
| Disease | male infertility (implicated_via_orthology) | CFAP47 KIT | 1.08e-03 | 13 | 112 | 2 | DOID:12336 (implicated_via_orthology) |
| Disease | Dyskeratosis Congenita | CTC1 PARN | 1.65e-03 | 16 | 112 | 2 | C0265965 |
| Disease | FEV/FEC ratio | USP34 TSHZ3 ITCH CRIM1 KIAA0586 DCBLD1 LAMC2 FRK HMCN1 ASTN2 LTBP1 HHIPL1 | 2.46e-03 | 1228 | 112 | 12 | EFO_0004713 |
| Disease | aortic measurement | WWP2 LRRC69 HMCN1 DISP2 SIGLEC11 | 2.74e-03 | 251 | 112 | 5 | EFO_0020865 |
| Disease | mean reticulocyte volume | CRIM1 NEXMIF NLRX1 TIGD6 NUP205 KCNA4 PTPRF MAST1 PCM1 | 3.45e-03 | 799 | 112 | 9 | EFO_0010701 |
