Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	uDENN	DENND5A MADD	6.51e-04	14	51	2	SM00800
Domain	uDENN	DENND5A MADD	7.50e-04	15	51	2	PF03456
Domain	UDENN	DENND5A MADD	8.56e-04	16	51	2	PS50946
Domain	DDENN	DENND5A MADD	8.56e-04	16	51	2	PS50947
Domain	DENN	DENND5A MADD	8.56e-04	16	51	2	SM00799
Domain	dDENN	DENND5A MADD	8.56e-04	16	51	2	SM00801
Domain	DENN	DENND5A MADD	8.56e-04	16	51	2	PF02141
Domain	dDENN_dom	DENND5A MADD	8.56e-04	16	51	2	IPR005112
Domain	uDENN_dom	DENND5A MADD	8.56e-04	16	51	2	IPR005113
Domain	dDENN	DENND5A MADD	8.56e-04	16	51	2	PF03455
Domain	DENN	DENND5A MADD	8.56e-04	16	51	2	PS50211
Domain	DENN_dom	DENND5A MADD	8.56e-04	16	51	2	IPR001194
Domain	TF_fork_head_CS_2	FOXM1 FOXI3	7.01e-03	46	51	2	IPR030456
Domain	TF_fork_head_CS_1	FOXM1 FOXI3	7.31e-03	47	51	2	IPR018122
Domain	FH	FOXM1 FOXI3	7.92e-03	49	51	2	SM00339
Domain	FORK_HEAD_1	FOXM1 FOXI3	7.92e-03	49	51	2	PS00657
Domain	FORK_HEAD_2	FOXM1 FOXI3	7.92e-03	49	51	2	PS00658
Domain	Fork_head_dom	FOXM1 FOXI3	7.92e-03	49	51	2	IPR001766
Domain	CUB	NETO1 MASP2	7.92e-03	49	51	2	PF00431
Domain	FORK_HEAD_3	FOXM1 FOXI3	7.92e-03	49	51	2	PS50039
Domain	Forkhead	FOXM1 FOXI3	7.92e-03	49	51	2	PF00250
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TAOK2 CNPPD1 MROH1 INF2 INPPL1 POLG SIPA1L3 KCNQ2 DENND5A HERC1 MADD IQCE	9.98e-08	1105	54	12	35748872
Pubmed	Mitochondrial DNA Maintenance Defects Overview	POLG AGK TFAM	1.59e-06	15	54	3	29517884
Pubmed	The impact of mitochondria-related POLG and TFAM variants on breast cancer pathomorphological characteristics and patient outcomes.	POLG TFAM	2.37e-06	2	54	2	33715547
Pubmed	A novel microRNA, hsa-miR-6852 differentially regulated by Interleukin-27 induces necrosis in cervical cancer cells by downregulating the FoxM1 expression.	FOXM1 IL27	2.37e-06	2	54	2	29343703
Pubmed	The expression of polymerase gamma and mitochondrial transcription factor A and the regulation of mitochondrial DNA content in mature human sperm.	POLG TFAM	2.37e-06	2	54	2	17339235
Pubmed	Acylglycerol kinase promotes paclitaxel resistance in nasopharyngeal carcinoma cells by regulating FOXM1 via the JAK2/STAT3 pathway.	FOXM1 AGK	2.37e-06	2	54	2	34116927
Pubmed	Mitochondrial DNA depletion and its correlation with TFAM, TFB1M, TFB2M and POLG in human diffusely infiltrating astrocytomas.	POLG TFAM	2.37e-06	2	54	2	20643228
Pubmed	The mtDNA replication-related genes TFAM and POLG are associated with leprosy in Han Chinese from Southwest China.	POLG TFAM	2.37e-06	2	54	2	28958595
Pubmed	Increased Total mtDNA Copy Number Cures Male Infertility Despite Unaltered mtDNA Mutation Load.	POLG TFAM	2.37e-06	2	54	2	28768180
Pubmed	RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment.	FOXM1 RNF8	7.09e-06	3	54	2	27526106
Pubmed	Composition and dynamics of human mitochondrial nucleoids.	POLG TFAM	7.09e-06	3	54	2	12686611
Pubmed	Interaction network analysis of YBX1 for identification of therapeutic targets in adenocarcinomas.	FOXM1 TOP2A	7.09e-06	3	54	2	31180040
Pubmed	Attempts to understand the mechanisms of mitochondrial diseases: The reverse genetics of mouse models for mitochondrial disease.	POLG TFAM	3.54e-05	6	54	2	33358867
Pubmed	Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1.	DHX58 ADAR	4.94e-05	7	54	2	34343497
Pubmed	Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship.	GPR153 GPR148	8.46e-05	9	54	2	15777626
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	FOXM1 POLG IQCN PPP1R15A TOP2A	1.26e-04	313	54	5	20800603
Pubmed	Molecular control of mitochondrial function in preimplantation mouse embryos.	POLG TFAM	1.29e-04	11	54	2	15895466
Pubmed	Large-scale concatenation cDNA sequencing.	CNPPD1 NECAB2 PKD2 DIO2 HERC1 CREB3L1	2.46e-04	568	54	6	9110174
Pubmed	A "double adaptor" method for improved shotgun library construction.	CNPPD1 NECAB2 PKD2 DIO2 HERC1 CREB3L1	2.60e-04	574	54	6	8619474
Pubmed	Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.	NECAB2 NETO1 TNC DIO2 TOP2A	2.94e-04	376	54	5	24154525
Pubmed	Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.	INF2 SIPA1L3 ADAR TFAM TOP2A HNRNPU	4.12e-04	626	54	6	33644029
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	INF2 NETO1 POLG SIPA1L3 PKD2 WDR27 IQCN DENND5A HNRNPU	4.40e-04	1489	54	9	28611215
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CNPPD1 NETO1 POLG SIPA1L3 SPTBN2 KCNQ2 SPRED1 MADD	7.80e-04	1285	54	8	35914814
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	DHX58 ADAR TFAM TOP2A HNRNPU	8.02e-04	469	54	5	37314180
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	SPTBN2 MRPL51 ADAR TFAM TOP2A HNRNPU	8.14e-04	713	54	6	29802200
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	SIPA1L3 ADAR TFAM TOP2A MADD HNRNPU	8.20e-04	714	54	6	28302793
Pubmed	Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.	TOP2A HNRNPU	8.72e-04	28	54	2	19596686
Pubmed	ATDC (Ataxia Telangiectasia Group D Complementing) Promotes Radioresistance through an Interaction with the RNF8 Ubiquitin Ligase.	RNF8 HNRNPU	8.72e-04	28	54	2	26381412
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	SIPA1L3 SPTBN2 ADAR HNRNPU	8.75e-04	274	54	4	34244482
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	SIPA1L3 SPTBN2 WDR27 ADAR TFAM IQCE	9.32e-04	732	54	6	34732716
Pubmed	EBF2 determines and maintains brown adipocyte identity.	DIO2 TFAM	9.35e-04	29	54	2	23499423
Pubmed	BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.	TOP2A HNRNPU	1.07e-03	31	54	2	23086144
Pubmed	D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.	PPP1R15A CREB3L1	1.07e-03	31	54	2	22925884
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	TAOK2 SPTBN2 MADD	1.10e-03	130	54	3	12421765
Pubmed	Immunosuppressive lncRNA LINC00624 promotes tumor progression and therapy resistance through ADAR1 stabilization.	ADAR HNRNPU	1.14e-03	32	54	2	36252997
Pubmed	The layered structure of human mitochondrial DNA nucleoids.	POLG TFAM	1.14e-03	32	54	2	18063578
Pubmed	Lhx2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth.	TNC FOXI3	1.21e-03	33	54	2	26952977
Pubmed	Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.	DENND5A MADD	1.52e-03	37	54	2	20937701
Pubmed	Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.	POLG TFAM	1.52e-03	37	54	2	20843780
Interaction	TOP3B interactions	TAOK2 CNPPD1 MROH1 INF2 INPPL1 POLG SIPA1L3 SPTBN2 KCNQ2 DENND5A HERC1 TFAM MADD IQCE HNRNPU	2.79e-06	1470	52	15	int:TOP3B
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-cycling_ENCC/glia\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXM1 COL20A1 FAM78B KCNQ2 TOP2A	4.57e-06	198	55	5	a11ac83dbd69d1c068971266d7c7343d114a6294
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-Glial_immature-cycling_ENCC/glia\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FOXM1 COL20A1 FAM78B KCNQ2 TOP2A	4.68e-06	199	55	5	9940f347973bf976ee23fb4b1cf1f349d96c21df
ToppCell	TCGA-Bile_Duct-Primary_Tumor\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	TAOK2 INPPL1 SIPA1L3 IQCE HNRNPU	4.79e-06	200	55	5	0350e5ffd36033099b7e32a1fdd790fff99790dc
ToppCell	TCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	TAOK2 INPPL1 SIPA1L3 IQCE HNRNPU	4.79e-06	200	55	5	ad2a6da0b1ae7a9212a3c91e5eec4baa7481d8dc
Drug	(R)-(+)-Atenolol [56715-13-0]; Down 200; 15uM; MCF7; HT_HG-U133A	TAOK2 INF2 GPR153 SIPA1L3 FAXDC2 PPP1R15A IQCE	4.39e-07	199	54	7	2855_DN
Drug	Carbetapentane citrate [23142-01-0]; Up 200; 7.6uM; MCF7; HT_HG-U133A	TAOK2 CNPPD1 GPR153 FAXDC2 PPP1R15A MASP2	7.32e-06	198	54	6	2623_UP
Drug	Dyclonine hydrochloride [536-43-6]; Down 200; 12.2uM; PC3; HT_HG-U133A	INF2 POLG SIPA1L3 PPP1R15A CREB3L1 MADD	7.75e-06	200	54	6	7261_DN
Drug	benzoylnorecgonine	FOXM1 CREB3L1	1.65e-05	3	54	2	CID000114718
Drug	NSC-163661	POLG AGK TFAM CREB3L1	3.03e-05	75	54	4	CID000005155
Drug	2',3'-dideoxycytidine (ddC	POLG TFAM CREB3L1 GPR148	3.19e-05	76	54	4	CID000005718
Drug	paromamine	CREB3L1 GPR148	3.30e-05	4	54	2	CID000439560
Drug	AC1L9KOU	TNC ADAR CREB3L1	3.54e-05	27	54	3	CID000447297
Disease	pleural tuberculosis (is_marker_for)	TNC IL27	1.31e-04	10	51	2	DOID:106 (is_marker_for)
Disease	Congenital total cataract	SIPA1L3 AGK	3.46e-04	16	51	2	C0266539
Disease	Epilepsy, Cryptogenic	POLG KCNQ2 HNRNPU	3.91e-04	82	51	3	C0086237
Disease	Awakening Epilepsy	POLG KCNQ2 HNRNPU	3.91e-04	82	51	3	C0751111
Disease	Aura	POLG KCNQ2 HNRNPU	3.91e-04	82	51	3	C0236018
Disease	Dystonia	SUOX KCNQ2 ADAR	4.50e-04	86	51	3	C0013421
Disease	spermatogenic failure (is_implicated_in)	FKBP6 IQCN	7.24e-04	23	51	2	DOID:0111910 (is_implicated_in)
Disease	Epilepsy	POLG KCNQ2 HNRNPU	8.98e-04	109	51	3	C0014544
Disease	Epileptic encephalopathy	DENND5A HNRNPU	1.24e-03	30	51	2	C0543888
Disease	hyperuricemia	SIPA1L3 PKD2	1.49e-03	33	51	2	EFO_0009104

Protein segments in the cluster

Peptide	Gene	Start	Entry
MTGLRWGSFRDAGVK	AGK	206	Q53H12
GAGLWEDGRSTLLPM	CREB3L1	431	Q96BA8
TSSSGELWRMVRIGG	CASTOR1	256	Q8WTX7
LGMSSWELPDLREGR	FAM78B	86	Q5VT40
MSRGAGRLQGTLWAL	FGF6	11	P10767
GLEWLRGSFLDSMRK	C17orf113	486	A0A1B0GUU1
RTGLGVIRMWADEGS	NETO1	261	Q8TDF5
ELGSRAGVMSDRSWF	IQCN	1006	Q9H0B3
SWRSLRTAGSMPLGG	IQCE	56	Q6IPM2
PGELGWLSMASREDL	FOXI3	126	A8MTJ6
STRGEWRRMLTSEGL	DIO2	46	Q92813
EGLLGRDKGSMWDQL	MADD	1286	Q8WXG6
GLGGLMNIWSLRDGS	HERC1	3766	Q15751
MDRRGGTWKLLGSVV	KCNQ2	211	O43526
IGWSLTTSGMLLGEE	HNRNPU	361	Q00839
MSDERRLPGSAVGWL	GPR153	1	Q6NV75
FGWMTLQGRKSRGTD	POLG	916	P54098
MDLEGGWELLRTSAG	MROH1	1286	Q8NDA8
SGLRKRLEGSDGGWM	INF2	51	Q27J81
MEFSWGSGQESRRLL	PCDHA4	1	Q9UN74
TLWGMELGLLSMRRG	FKBP6	91	O75344
WGSMRRTAFILGSGL	FAXDC2	21	Q96IV6
SSCLEGSMGLRSLWG	CNPPD1	296	Q9BV87
GSMGLRSLWGSLLAS	CNPPD1	301	Q9BV87
TWDGIRLGERLRTMS	ADAR	1021	P55265
RLQMKWRESEGSGLG	COL20A1	41	Q9P218
GGLTVGDWLDSIRMG	EPHA8	931	P29322
ISSSSLGGWELGRMA	GPR148	106	Q8TDV2
MGQTAGDLGWRLSLL	IL27	1	Q8NEV9
LDGRWTVTTLSGDMG	DHX58	71	Q96C10
RWLGKGMDDGSLERI	DENND5A	1046	Q6IQ26
FMRTDDIGTASGWGL	MASP2	561	O00187
WLRKMSSDGLGSRSI	FOXM1	186	Q08050
MGLLSRAWSRLRGLG	PPP1R15A	26	O75807
RRVGMSAGWLLLEDG	RNF8	21	O76064
MLLSWGGGESRRPVQ	LINC00869	1	P0C866
GWETVDMTLRRNGLG	SIPA1L3	961	O60292
LGEAGMSAWLRAIGL	INPPL1	1196	O15357
LGAVLGLSWRRGLMG	TAOK2	1026	Q9UL54
SMWGVLSALGRSGAE	TFAM	6	Q00059
SMDLEGLEWLGRASP	LINC00477	86	Q96M19
MGATGLGFLLSWRQD	PRY	1	O14603
LWEAEMERLRGSGTP	TMC8	21	Q8IU68
GSLESQMSELWGVRG	ZC3H12A	441	Q5D1E8
RLEALGTGWEELGRM	SPTBN2	1146	O15020
MAGNLLSGAGRRLWD	MRPL51	1	Q4U2R6
GTPEAEGRARLMLSW	UROC1	611	Q96N76
VMTRDDSSGGWLPLG	SPRED1	21	Q7Z699
MTSDGGGWIVFLRRK	TNC	2016	P24821
MSSGGGSRGLLAWLL	PRSS42P	1	Q7Z5A4
GLRGLWGTRLMEESS	PKD2	196	Q13563
GLRKEWLLGMLGAES	TOP2A	1031	P11388
STQGWRVMGTLLGLG	SUOX	51	P51687
DGTLRMWSARGAELA	WDR27	576	A2RRH5
PRERSQAGGMGTLWS	KEL	11	P23276
ALGGLLRWVGARMGE	NECAB2	26	Q7Z6G3