Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessestablishment of protein localization to plasma membrane

PHAF1 AFDN PREPL SCARB2

7.26e-0676344GO:0061951
GeneOntologyBiologicalProcessregulation of mini excitatory postsynaptic potential

AFDN SYNE1

2.63e-055342GO:0061884
GeneOntologyBiologicalProcessmini excitatory postsynaptic potential

AFDN SYNE1

2.63e-055342GO:0098816
GeneOntologyBiologicalProcessmodulation of excitatory postsynaptic potential

AFDN GRIK2 SYNE1

1.67e-0465343GO:0098815
GeneOntologyBiologicalProcessglycosylceramide catabolic process

GALC SCARB2

1.72e-0412342GO:0046477
GeneOntologyBiologicalProcesscarbohydrate derivative catabolic process

OGDHL GALC MANBA SCARB2 SRC

1.75e-04323345GO:1901136
GeneOntologyBiologicalProcessprotein localization to plasma membrane

PHAF1 AFDN PREPL PDPK1 SCARB2

1.78e-04324345GO:0072659
GeneOntologyBiologicalProcesspositive regulation of integrin activation

PCSK5 SRC

2.37e-0414342GO:0033625
GeneOntologyBiologicalProcesscarbohydrate catabolic process

OGDHL MANBA SCARB2 SRC

2.93e-04196344GO:0016052
GeneOntologyCellularComponenttrans-Golgi network

PCSK5 PHAF1 NDST1 PREPL DOP1B

1.69e-04306365GO:0005802
GeneOntologyCellularComponentsomatodendritic compartment

PCSK5 PHAF1 AFDN GRIK2 PLCB4 USH2A SYNE1 PDPK1 SRC

1.80e-041228369GO:0036477
GeneOntologyCellularComponentlysosomal lumen

GALC MANBA SCARB2

6.38e-0498363GO:0043202
GeneOntologyCellularComponentGolgi apparatus subcompartment

PCSK5 PHAF1 NDST1 PREPL DOP1B

9.16e-04443365GO:0098791
DomainHelicase_C

ERCC6L2 DDX5 DHX8

1.14e-03107363PF00271
DomainHELICc

ERCC6L2 DDX5 DHX8

1.14e-03107363SM00490
DomainHelicase_C

ERCC6L2 DDX5 DHX8

1.17e-03108363IPR001650
DomainHELICASE_CTER

ERCC6L2 DDX5 DHX8

1.20e-03109363PS51194
DomainHELICASE_ATP_BIND_1

ERCC6L2 DDX5 DHX8

1.20e-03109363PS51192
DomainDEXDc

ERCC6L2 DDX5 DHX8

1.20e-03109363SM00487
DomainHelicase_ATP-bd

ERCC6L2 DDX5 DHX8

1.23e-03110363IPR014001
DomainC2

PLCB4 FER1L6 CPNE3

2.03e-03131363PF00168
DomainDNA/RNA_helicase_DEAH_CS

ERCC6L2 DHX8

2.07e-0335362IPR002464
Domain-

GALC MANBA

2.07e-03353623.20.20.80
DomainC2

PLCB4 FER1L6 CPNE3

2.31e-03137363SM00239
DomainGlyco_hydro_catalytic_dom

GALC MANBA

2.43e-0338362IPR013781
DomainDEAH_ATP_HELICASE

ERCC6L2 DHX8

2.43e-0338362PS00690
DomainC2

PLCB4 FER1L6 CPNE3

2.56e-03142363PS50004
Domain-

ERCC6L2 NDST1 DNAJC27 SAMD9 DDX5 DHX8

2.78e-037463663.40.50.300
Domain-

PLCB4 FER1L6 CPNE3

2.87e-031483632.60.40.150
DomainC2_dom

PLCB4 FER1L6 CPNE3

3.84e-03164363IPR000008
DomainGlycoside_hydrolase_SF

GALC MANBA

4.68e-0353362IPR017853
DomainP-loop_NTPase

ERCC6L2 NDST1 DNAJC27 SAMD9 DDX5 DHX8

5.22e-03848366IPR027417
Domain-

PCSK5 MANBA

8.71e-03733622.60.120.260
DomainDEAD

DDX5 DHX8

8.71e-0373362PF00270
DomainDEAD/DEAH_box_helicase_dom

DDX5 DHX8

8.71e-0373362IPR011545
Pubmed

Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding.

PDPK1 SRC

1.04e-06236218024423
Pubmed

Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity.

PDPK1 SRC

1.04e-06236211481331
Pubmed

TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.

PDPK1 SRC

3.12e-06336218616680
Pubmed

Regulation of c-Src by binding to the PDZ domain of AF-6.

AFDN SRC

3.12e-06336217491594
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

AFDN URB1 RRP36 SYNE1 DDX5 SRC DHX8 CPNE3

7.99e-06102436824711643
Pubmed

Regulation of Akt/PKB activation by tyrosine phosphorylation.

PDPK1 SRC

1.56e-05636211445557
Pubmed

Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding.

PDPK1 SRC

2.18e-05736210896934
Pubmed

Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein.

AFDN SRC

4.66e-051036222027834
Pubmed

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

SYNE1 ARNT2

1.76e-041936218711365
Pubmed

PHD finger protein 1 (PHF1) is a novel reader for histone H4R3 symmetric dimethylation and coordinates with PRMT5-WDR77/CRL4B complex to promote tumorigenesis.

DDX5 SRC

4.75e-043136229846670
Pubmed

Immunosuppressive lncRNA LINC00624 promotes tumor progression and therapy resistance through ADAR1 stabilization.

DDX5 CPNE3

5.07e-043236236252997
Pubmed

Genetic mapping of the human and mouse phospholipase C genes.

PLCB4 SRC

5.39e-04333628672127
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

SCARB2 DDX5 TSPAN1 SRC DOP1B CPNE3

5.63e-04101636619056867
Pubmed

Endogenous human MDM2-C is highly expressed in human cancers and functions as a p53-independent growth activator.

OGDHL DDX5

6.42e-043636224147044
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

NDST1 AFDN PLCB4 TENM3 SYNE1

8.26e-0471936535337019
Pubmed

ITCH nuclear translocation and H1.2 polyubiquitination negatively regulate the DNA damage response.

DDX5 CPNE3

8.33e-044136230517763
Pubmed

Genetic loci associated with circulating levels of very long-chain saturated fatty acids.

LVRN SPTLC3

8.74e-044236225378659
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ERCC6L2 PCSK5 PLCB4 PREPL ARNT2

4.10e-071883656468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ERCC6L2 PCSK5 PLCB4 PREPL ARNT2

4.10e-071883657a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ERCC6L2 PCSK5 PLCB4 PREPL ARNT2

4.10e-071883659cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6-|Neuronal / cells hierarchy compared to all cells using T-Statistic

PCSK5 GRIK2 SAMD9 TENM3 PCDH11Y

5.56e-07200365a9cdddc4e985dae59521e557479c24fcc2ac727d
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6--L3-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

PCSK5 GRIK2 SAMD9 TENM3 PCDH11Y

5.56e-0720036533b9199e0dfc267e2cea20b82d1c167f8adcc635
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6|Neuronal / cells hierarchy compared to all cells using T-Statistic

PCSK5 GRIK2 SAMD9 TENM3 PCDH11Y

5.56e-072003659719fabddc34051949468a7520289e3c750de4f8
ToppCellAdult-Epithelial-lung_goblet_cell-D175|Adult / Lineage, Cell type, age group and donor

URB1 PLCB4 FER1L6 TSPAN1

9.15e-061643646e6aedb61f8e195d52e028fdda750a29bb14e57e
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLCB4 FER1L6 TSPAN1 ARNT2

1.08e-05171364eddc5e05003382603ee49f74b9e2242a43021096
ToppCellCOVID-19-kidney-PEC|kidney / Disease (COVID-19 only), tissue and cell type

PLCB4 TENM3 SYNE1 ARNT2

1.10e-0517236436a96714a0eb6ac438648135336c9791881ddadb
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLCB4 TENM3 SYNE1 ARNT2

1.35e-051813645f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLCB4 TENM3 SYNE1 ARNT2

1.35e-05181364c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OGDHL TENM3 USH2A PREPL

1.70e-051923645b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 GRIK2 TENM3 PCDH11Y

1.74e-05193364d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 GRIK2 TENM3 PCDH11Y

1.74e-051933643ed46f5a7419ec4eddbd0df0d9b5f53aa486198b
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 GRIK2 TENM3 PCDH11Y

1.74e-05193364e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 GRIK2 TENM3 PCDH11Y

1.74e-05193364658c2b30a4d806c5ce78ea4392fe8eb86b8d1e99
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

URB1 PLCB4 FER1L6 TSPAN1

1.77e-05194364e0228f593c3493175962a4817500d4337ddc4e88
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 GRIK2 TENM3 PCDH11Y

1.77e-051943641bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCellmLN-(5)_Dendritic_cell-(54)_pDC|mLN / shred on region, Cell_type, and subtype

PLCB4 SCARB2 TSPAN1 SRC

1.96e-051993641e738219784a446ee8b0ddeb408e0050e1929e60
ToppCellmLN-Dendritic_cell-pDC|mLN / Region, Cell class and subclass

PLCB4 SCARB2 TSPAN1 SRC

1.96e-0519936454f1abb57af7bf8a8b82a38b933f257df3b5d8df
ToppCellBronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

URB1 PLCB4 TSPAN1 DOP1B

2.00e-05200364ed093626a9cac7531a2bf02f6e345c5e84b8c060
ToppCellfacs-Thymus-Epithelium-3m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRIK2 PREPL DHX8

1.40e-041253636bdbbd47b699d836900bd055f2144cf960b5e7b6
ToppCellLPS-IL1RA-Lymphocytic_NKT-iNKT/MAIT-Erythroid|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SAMD9 TAGAP ARNT2

1.68e-041333632ec3490cbf60152c3cece95eb566d749c9666517
ToppCellControl-Fibroblasts-Mesothelial_FB|Control / group, cell type (main and fine annotations)

PLCB4 TENM3 ARNT2

1.91e-04139363e769beb031b262dd92c9605b07dbf3c29fb82520
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree-Tuft|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

OGDHL TENM3 ARNT2

3.00e-041623630ccdb224ee3c585a6d0caffde5608d9d3cc452f8
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree-Tuft-Tuft_L.0.7.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

OGDHL TENM3 ARNT2

3.00e-041623639ccee8e7e78e16b0149a94867e12d86d3b04f9b9
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

OGDHL TENM3 ARNT2

3.00e-041623630d35752a7249b3c62b8007ec8a775c37d16b8d31
ToppCell5'-Adult-Appendix-Epithelial-Tuft-related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

OGDHL GRIK2 SRC

3.00e-04162363ded08da888d8c481f0f96d1e0bfd03d617966910
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LVRN GRIK2 SYNE1

3.16e-04165363e2aebb2fe197151e019371b8960f76f0c2386f08
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LVRN GRIK2 SYNE1

3.16e-04165363b087771499aeb31cc4a338d2d0a9392a4ec1ac45
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SPTLC3 OGDHL DOP1B

3.16e-04165363dc570154baed59ed109e5369589448e075ba66a9
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LVRN GRIK2 SYNE1

3.16e-04165363d8f8b088fd28a6b9dbd6b51bcaee42000e963321
ToppCellAdult-Epithelial-lung_goblet_cell-D122|Adult / Lineage, Cell type, age group and donor

PLCB4 FER1L6 TSPAN1

3.28e-041673636efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_SLITRK6|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 SAMD9 FER1L6

3.39e-04169363c5873c0058f6a62e97b929e61dd25312d09dda39
ToppCellBL-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SPTLC3 OGDHL TENM3

3.45e-04170363b465df2dac6b4e98b4ede6ad0c6347656757885c
ToppCell368C-Lymphocytic-ILC|368C / Donor, Lineage, Cell class and subclass (all cells)

PHAF1 PDPK1 DOP1B

3.51e-041713633b3143e4aa6520ee9c6b6f2482206ad3d8205d14
ToppCell368C-Lymphocytic-ILC-ILC-2|368C / Donor, Lineage, Cell class and subclass (all cells)

PHAF1 PDPK1 DOP1B

3.51e-04171363fd01076574dcc82bfd4a1538812500543b16794f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 PLCB4 PCDH11Y

3.70e-04174363e4d65fe121a32ac4cdd6312e7b8f867f0852e991
ToppCellAdult-Epithelial-lung_goblet_cell-D231|Adult / Lineage, Cell type, age group and donor

PLCB4 FER1L6 TSPAN1

3.70e-041743637d2f802f493f19a068e097b2909a9000e2160266
ToppCellnormal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells|normal_Lymph_Node / Location, Cell class and cell subclass

PLCB4 SCARB2 TSPAN1

3.76e-0417536329fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

URB1 FER1L6 TSPAN1

3.88e-04177363779ba86f53650772755b52460be03f18bb204e55
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

URB1 FER1L6 TSPAN1

3.88e-041773630f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 PLCB4 PCDH11Y

3.88e-04177363bde307e67ad8e48a5ff4c0827015f4688f6b3e46
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 PLCB4 PCDH11Y

3.88e-041773634c069f0d044a96118090b85ca592a21d6b5d9399
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLCB4 SYNE1 DDX5

3.95e-0417836301dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellRV-11._Adipocyte|RV / Chamber and Cluster_Paper

LVRN PCSK5 TENM3

3.95e-04178363278bbea5cf8f0589f71675c7a3d00679391b5253
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

PCSK5 PLCB4 PCDH11Y

4.01e-041793631ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCell3'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GRIK2 USH2A ARNT2

4.01e-04179363878b15ea62e3405682a538f79f58d74b9cd3f398
ToppCellAdult-Epithelial-lung_goblet_cell|Adult / Lineage, Cell type, age group and donor

PLCB4 FER1L6 TSPAN1

4.01e-041793631fc1f252ca943a2f649d1e627f56acbf15f8e058
ToppCellCOVID-19-kidney-Epi_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

TENM3 SYNE1 ARNT2

4.01e-04179363e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LVRN MANBA PDPK1

4.01e-04179363e880c507f11ce75d104593a4ca29f0295f8125e8
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 PLCB4 PCDH11Y

4.01e-041793637954c0026754ab869b88ab7feb13c2f27d6e272d
ToppCell368C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PHAF1 PDPK1 DOP1B

4.08e-04180363eb5a57604c7f2ad256c300085dbf5069d0ae1ad0
ToppCell368C-Lymphocytic-ILC|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PHAF1 PDPK1 DOP1B

4.08e-04180363ddba4dc3bbcfe4e4a22400be73bbc62d3ff27d3c
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo-neutrophil-myelocyte|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

PREPL SYNE1 CPNE3

4.21e-0418236352eac2f892ea7f26731e0b21c578fd2665a1657a
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLCB4 FER1L6 TSPAN1

4.21e-04182363818b5155ec81f0059048d6070a108116ecd72e3c
ToppCell10x3'2.3-week_12-13-Mesenchymal_osteo-stroma-osteoblast|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

GRIK2 TENM3 TSPAN1

4.21e-04182363193cb2df3d7ea4cb9a11390b92955e7d9b0a053a
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTLC3 MANBA TSPAN1

4.28e-041833637eaa6ef7c6cf848fd6489f97677f4406318da22f
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 GRIK2 PLCB4

4.28e-04183363351d575339038bd4a66f408da518c567444208e8
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 GRIK2 PLCB4

4.35e-04184363f506d0ee48f39d6f59f19554217dfdf0987cc405
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 GRIK2 PLCB4

4.35e-041843638bcb1c4bc8ffef74338cdade926a94711de93c64
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

GRIK2 PLCB4 TENM3

4.42e-041853638ed10ba581849c9c4ac4397226be2b62b4b3b900
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

PLCB4 TENM3 PCDH11Y

4.42e-041853637dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCellFetal_29-31_weeks-Mesenchymal-chondrocyte|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

GRIK2 PLCB4 TENM3

4.42e-04185363b8052cebb73f41abe6faf0aa847be7c8ef23ae94
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TENM3 SYNE1 ARNT2

4.42e-0418536334fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TENM3 SYNE1 ARNT2

4.42e-041853638816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCellpdx|World / Sample and Cell Type and Tumor Cluster (all cells)

PCSK5 SPTLC3 PLCB4

4.49e-04186363de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCellpdx-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

PCSK5 SPTLC3 PLCB4

4.49e-041863630b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

PLCB4 TENM3 PCDH11Y

4.56e-041873635258674d0346e5c51a4b965efcdc1790c970845d
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 GRIK2 TENM3

4.56e-0418736385f1678338a47d91e296f0620d4887f057eb7e70
ToppCell(04)_Pre-ciliated-(3)_72hpi|(04)_Pre-ciliated / shred by cell type and Timepoint

GALC PTCHD3 PARP16

4.63e-04188363f911dc61b008b60aaa2a1e9354085f480a669e2c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TENM3 SYNE1 ARNT2

4.63e-04188363874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TENM3 SYNE1 ARNT2

4.63e-04188363b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCellMesenchymal-chondrocyte|World / Lineage, Cell type, age group and donor

GRIK2 PLCB4 TENM3

4.63e-041883637b1e3f8a941eaa68e89c562129a92314642eec66
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

URB1 TENM3 SYNE1

4.78e-041903631121eb607a984c59fbffe7220837fc178745aa55
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_monocytic-intermediate_monocyte|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SYNE1 DOP1B CPNE3

4.78e-04190363896b5825edb30fe62cbbed6078570c1f8057a99e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

URB1 TENM3 SYNE1

4.78e-04190363048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

GRIK2 PLCB4 TENM3

4.85e-04191363273c4a757292a9301de0eaeacdec91c9866be229
ToppCellPSB-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

OGDHL TENM3 TAGAP

4.85e-041913638f4637e801554e2343b974fe7794f01dd2151418
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 GRIK2 PCDH11Y

5.00e-04193363c7e9e6e4bf5e07c9cbdf1aa7c8828f4b2500e3ff
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-goblet|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FER1L6 TSPAN1 DOP1B

5.00e-04193363402aad2f9e789ad1f2e1536cdc9ce61de7625427
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK2 TENM3 PCDH11Y

5.00e-04193363010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCellCD8+_Memory_T_cell-CV-0|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

TAGAP SYNE1 DDX5

5.00e-04193363995781d87a919c0380750878bafe584342bb83ad
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK2 TENM3 PCDH11Y

5.00e-041933632189da4b727e25e62669d7b9257f06493be21a27
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FER1L6 TSPAN1 DOP1B

5.00e-041933637ee3b1ef5c455f321b4e154ae62c69543fe9b30e
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PCSK5 SAMD9 SYNE1

5.08e-041943636be74e4ba631b0c46cef2c580553f4c1ed29579e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 TENM3 PCDH11Y

5.08e-0419436383863da11dfbe59b2d0a2c08db40b537c150588c
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

PLCB4 SYNE1 TSPAN1

5.15e-04195363fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellCOVID-19_Severe-Classical_Monocyte-cMono_4|Classical_Monocyte / Disease condition and Cell class

SAMD9 TAGAP SRC

5.15e-041953631992a1673b7213e25f3c76ac77da35c57daceddd
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

PLCB4 SYNE1 TSPAN1

5.15e-04195363eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellCOVID-19_Severe-Classical_Monocyte-cMono_4|COVID-19_Severe / Disease condition and Cell class

SAMD9 TAGAP SRC

5.15e-04195363787ea9f38ad8e2a836222ca97f4d927f7e79517d
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-goblet|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FER1L6 TSPAN1 DOP1B

5.15e-0419536309605533aa5947bb2e5a6725c1ce89f79d330bf5
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FER1L6 TSPAN1 DOP1B

5.15e-041953637ff04c45a02df01e3816f3c1d43585a93182a730
ToppCellCOVID-19_Severe-Neu_2|World / 5 Neutrophil clusters in COVID-19 patients

SYNE1 DOP1B CPNE3

5.23e-0419636316359a56297f0558fc93fa52563cce0c53def167
ToppCell5'-Adult-LargeIntestine-Epithelial-goblet|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FER1L6 TSPAN1 DOP1B

5.23e-04196363847b3377f463bfded046eec63cc1b547f3dc33c1
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

PLCB4 SYNE1 TSPAN1

5.23e-041963636d02d494196e3f857d53eea46d9419690d43beca
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

PLCB4 SYNE1 TSPAN1

5.23e-04196363af4cdc61830685a888a1209826c23bcf54a43084
ToppCell5'-Adult-LargeIntestine-Epithelial-goblet-BEST2+_Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FER1L6 TSPAN1 DOP1B

5.31e-04197363d624f3a105b19f19a0dd253ce8de3ed13adc1f01
ToppCellCOVID-19_Severe-Neu_2|COVID-19_Severe / 5 Neutrophil clusters in COVID-19 patients

SYNE1 DOP1B CPNE3

5.31e-04197363945f19475905cdedf232315eea1076ca0b753b67
ToppCell5'-Adult-LargeIntestine-Epithelial-Tuft-related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

OGDHL SAMD9 TSPAN1

5.39e-04198363a631be84e29c277216d89ec6265bd43e87c1dc86
DrugTadjakonine [11087-94-8]; Up 200; 7.4uM; MCF7; HT_HG-U133A

OGDHL AFDN URB1 SYNE1 SRC DOP1B

5.75e-071953664424_UP
Drugtriazene

PCSK5 MANBA SYNE1

8.15e-0625363CID000115034
DrugDiphenhydramine hydrochloride [147-24-0]; Down 200; 13.8uM; MCF7; HT_HG-U133A

SAMD9 TENM3 PARP16 SCARB2 SRC

1.20e-051913656020_DN
DrugMephenytoin [50-12-4]; Up 200; 18.4uM; MCF7; HT_HG-U133A

OGDHL AFDN SAMD9 SYNE1 DOP1B

1.47e-051993653580_UP
DiseaseAlpha ketoglutarate measurement

SAMD9 TENM3

1.72e-0416362EFO_0010457
Diseasecolorectal cancer, inflammatory bowel disease

GRIK2 PTCHD3

2.44e-0419362EFO_0003767, MONDO_0005575
Diseaselifestyle measurement, anxiety disorder measurement

GRIK2 URB1 USH2A

6.25e-04137363EFO_0007795, EFO_0010724
Disease5-HIAA measurement

PCSK5 AFDN

1.04e-0339362EFO_0005132
Diseaseglucose metabolism measurement, age-related hearing impairment

PCSK5 SAMD9

1.85e-0352362EFO_0005782, EFO_0009367
Diseaseeye colour measurement

ERCC6L2 USH2A ARNT2

2.37e-03218363EFO_0009764

Protein segments in the cluster

PeptideGeneStartEntry
YTREYFTFPASKSQD

AFDN

1226

P55196
NPQFSKTFIIDYYFE

CPNE3

56

O75131
ASYFEFEVINYFNPK

LVRN

441

Q6Q4G3
SQTFNYYFPEEKFES

FAM200A

431

Q8TCP9
SSFTFQNPYSDEIEY

ARNT2

416

Q9HBZ2
PFFYEVRNEFYKDTQ

DNAJC27

76

Q9NZQ0
ISNSYEDQSSYFFEK

DOP1B

316

Q9Y3R5
KFVINYDYPNSSEDY

DDX5

411

P17844
YDFSRAQSTYFNDPK

PCSK5

116

Q92824
YPAFTKDFEVSQLYD

OGDHL

796

Q9ULD0
DFYFEKSANYFDSEV

NDST1

671

P52848
FEIEYFDPANAKFYE

PARP16

126

Q8N5Y8
NYFTFSPIYDKSAQE

MANBA

216

O00462
RDFYASQYPEVKEFF

ERCC6L2

1271

Q5T890
NKDSFYVSLYPDFSS

GRIK2

141

Q13002
FPSTYKDDFNVDYPF

GALC

486

P54803
DAVKFSQYFYEAPIF

DHX8

721

Q14562
DSYITPYFNVEENYF

PTCHD3

636

Q3KNS1
NDNSPVFTHNEYKFY

PCDH11Y

596

Q9BZA8
TVKEGTNSPFYNEYF

FER1L6

116

Q2WGJ9
TNSPFYNEYFVFDFI

FER1L6

121

Q2WGJ9
FSDKEGIQPFQEYSY

USH2A

3551

O75445
QAFLEDYFTSTEPQY

SRC

516

P12931
NDEIEPTAFSYEKFY

PLCB4

196

Q15147
PVFEADQFQYAKESY

TAGAP

716

Q8N103
FIENSKFFEQYEVTY

SYNE1

546

Q8NF91
FDEFSNPYRYKLDFS

SAMD9

166

Q5K651
YFTFQDDEKLYFGLS

PDPK1

146

O15530
YTQFYFFNVTNPEEI

SCARB2

61

Q14108
KDFVPLYQDFENFYT

SPTLC3

101

Q9NUV7
FFSTQYKDEFPFKYQ

TEX45

446

Q8NA69
QVPSKCNDYFFNYFT

PHAF1

276

Q9BSU1
YQFFYSSDFEQKTEQ

URB1

1771

O60287
PFANTTKYAYEYDVD

TENM3

2121

Q9P273
NERFYTEKDPSYFVF

PREPL

241

Q4J6C6
SGEYNPEVFDKTYQF

RRP36

126

Q96EU6
SKFFYKFFQEFTQEP

ZNF131

56

P52739
GFTNYTDFEDSPYFK

TSPAN1

151

O60635