Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	odorant binding	OR5H2 OR5K2 OR5K1 OR5H8	7.01e-05	127	35	4	GO:0005549
GeneOntologyMolecularFunction	olfactory receptor activity	OR52R1 OR5H2 OR5K2 OR5K1 OR52B6 OR5H8	9.32e-05	431	35	6	GO:0004984
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activator activity	EPGN AREG	6.74e-04	22	35	2	GO:0030297
GeneOntologyMolecularFunction	G protein-coupled receptor activity	ADGRG5 OR52R1 OR5H2 OR5K2 OR5K1 OR52B6 OR5H8	7.38e-04	884	35	7	GO:0004930
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	MAP3K6 MAP3K5	1.02e-03	27	35	2	GO:0004709
GeneOntologyMolecularFunction	protein tyrosine kinase activator activity	EPGN AREG	1.81e-03	36	35	2	GO:0030296
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	ADGRG5 OR52R1 OR5H2 OR5K2 OR5K1 OR52B6 IL17RB OR5H8	1.97e-03	1353	35	8	GO:0004888
GeneOntologyMolecularFunction	epidermal growth factor receptor binding	EPGN AREG	2.34e-03	41	35	2	GO:0005154
GeneOntologyMolecularFunction	protein serine kinase activity	HIPK3 ALPK1 MAP3K6 MAP3K5	3.60e-03	363	35	4	GO:0106310
GeneOntologyBiologicalProcess	medial motor column neuron differentiation	LHX3 LHX4	2.96e-06	2	36	2	GO:0021526
GeneOntologyBiologicalProcess	somatic motor neuron differentiation	LHX3 LHX4	2.95e-05	5	36	2	GO:0021523
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR52R1 OR5H2 OR5K2 OR5K1 OR52B6 OR5H8	9.32e-05	432	36	6	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR52R1 OR5H2 OR5K2 OR5K1 OR52B6 OR5H8	1.39e-04	465	36	6	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR52R1 OR5H2 OR5K2 OR5K1 OR52B6 OR5H8	1.75e-04	485	36	6	GO:0050907
GeneOntologyBiologicalProcess	detection of stimulus	OR52R1 OR5H2 OR5K2 PKD1L2 OR5K1 OR52B6 OR5H8	2.15e-04	722	36	7	GO:0051606
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR52R1 OR5H2 OR5K2 OR5K1 OR52B6 OR5H8	2.66e-04	524	36	6	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR52R1 OR5H2 OR5K2 OR5K1 OR52B6 OR5H8	3.35e-04	547	36	6	GO:0007606
GeneOntologyBiologicalProcess	regulation of MAP kinase activity	HIPK3 EPGN HYAL2 MAP3K5	3.53e-04	194	36	4	GO:0043405
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR52R1 OR5H2 OR5K2 OR5K1 OR52B6 OR5H8	4.66e-04	582	36	6	GO:0050906
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	ADGRG5 OR52R1 OR5H2 OR5K2 OR5K1 OR52B6 AREG OR5H8 BICD1	5.12e-04	1395	36	9	GO:0007186
HumanPheno	Inappropriate antidiuretic hormone secretion	LHX3 LHX4	4.52e-05	8	7	2	HP:0031218
HumanPheno	Pituitary dwarfism	LHX3 LHX4	7.25e-05	10	7	2	HP:0000839
HumanPheno	Decreased thyroid-stimulating hormone level	LHX3 LHX4	1.06e-04	12	7	2	HP:0031098
HumanPheno	Abnormal radioactive iodine uptake test result	LHX3 LHX4	1.46e-04	14	7	2	HP:0031221
HumanPheno	Reduced radioactive iodine uptake	LHX3 LHX4	1.46e-04	14	7	2	HP:0031219
HumanPheno	Maternal autoimmune disease	LHX3 LHX4	1.46e-04	14	7	2	HP:0011437
HumanPheno	Decreased cervical spine mobility	LHX3 LHX4	1.69e-04	15	7	2	HP:0004637
HumanPheno	Delayed proximal femoral epiphyseal ossification	LHX3 LHX4	2.18e-04	17	7	2	HP:0008828
HumanPheno	Large posterior fontanelle	LHX3 LHX4	2.74e-04	19	7	2	HP:0004491
HumanPheno	Ectopic posterior pituitary	LHX3 LHX4	3.36e-04	21	7	2	HP:0011755
HumanPheno	Abnormal circulating thyroglobulin concentration	LHX3 LHX4	3.69e-04	22	7	2	HP:0025483
HumanPheno	Reduced circulating prolactin concentration	LHX3 LHX4	3.69e-04	22	7	2	HP:0008202
HumanPheno	Decreased circulating T4 concentration	LHX3 LHX4	4.04e-04	23	7	2	HP:0031507
HumanPheno	Thyroid hypoplasia	LHX3 LHX4	4.04e-04	23	7	2	HP:0005990
HumanPheno	Posterior pituitary dysgenesis	LHX3 LHX4	4.40e-04	24	7	2	HP:0011753
HumanPheno	Aplasia/Hypoplasia of the thyroid gland	LHX3 LHX4	4.78e-04	25	7	2	HP:0033079
HumanPheno	Abnormal ossification involving the femoral head and neck	LHX3 LHX4	4.78e-04	25	7	2	HP:0009107
HumanPheno	Abnormal circulating T4 concentration	LHX3 LHX4	5.18e-04	26	7	2	HP:0031505
HumanPheno	Thyroid dysgenesis	LHX3 LHX4	5.18e-04	26	7	2	HP:0008188
HumanPheno	Decreased circulating ACTH concentration	LHX3 LHX4	6.91e-04	30	7	2	HP:0002920
HumanPheno	Abnormal prolactin level	LHX3 LHX4	6.91e-04	30	7	2	HP:0040086
HumanPheno	Panhypopituitarism	LHX3 LHX4	7.39e-04	31	7	2	HP:0000871
HumanPheno	Decreased circulating luteinizing hormone level	LHX3 LHX4	7.39e-04	31	7	2	HP:0030344
HumanPheno	Decreased circulating follicle stimulating hormone concentration	LHX3 LHX4	7.87e-04	32	7	2	HP:0030341
HumanPheno	Anterior pituitary hypoplasia	LHX3 LHX4	9.97e-04	36	7	2	HP:0010627
HumanPheno	Abnormal circulating thyroid hormone concentration	LHX3 LHX4	1.05e-03	37	7	2	HP:0031508
HumanPheno	Decreased circulating gonadotropin concentration	LHX3 LHX4	1.11e-03	38	7	2	HP:0030339
HumanPheno	Pituitary hypothyroidism	LHX3 LHX4	1.11e-03	38	7	2	HP:0008245
HumanPheno	Anterior pituitary dysgenesis	LHX3 LHX4	1.17e-03	39	7	2	HP:0010625
HumanPheno	Delayed epiphyseal ossification	LHX3 LHX4	1.36e-03	42	7	2	HP:0002663
HumanPheno	Thoracolumbar scoliosis	IGBP1 LHX3	1.42e-03	43	7	2	HP:0002944
HumanPheno	Abnormal circulating adrenocorticotropin concentration	LHX3 LHX4	1.49e-03	44	7	2	HP:0011043
HumanPheno	Abnormal thyroid-stimulating hormone level	LHX3 LHX4	1.70e-03	47	7	2	HP:0031097
HumanPheno	Overweight	LHX3 LHX4	1.85e-03	49	7	2	HP:0025502
HumanPheno	Abnormal posterior pituitary morphogenesis	LHX3 LHX4	2.32e-03	55	7	2	HP:0011751
HumanPheno	Hypothermia	LHX3 LHX4	2.49e-03	57	7	2	HP:0002045
MousePheno	abnormal Rathke's pouch development	LHX3 LHX4	1.26e-04	10	24	2	MP:0013351
MousePheno	decreased gonadotroph cell number	LHX3 LHX4	1.54e-04	11	24	2	MP:0008335
MousePheno	decreased thyroid-stimulating hormone level	LHX3 LHX4	2.93e-04	15	24	2	MP:0005134
MousePheno	abnormal gonadotroph morphology	LHX3 LHX4	2.93e-04	15	24	2	MP:0008325
Domain	DUF4071	MAP3K6 MAP3K5	1.02e-05	3	35	2	IPR025136
Domain	DUF4071	MAP3K6 MAP3K5	1.02e-05	3	35	2	PF13281
Domain	EGF_rcpt_ligand	EPGN AREG	5.09e-05	6	35	2	IPR015497
Domain	XK_rel	XKRX XKRY	1.86e-04	11	35	2	IPR018629
Domain	XK-related	XKRX XKRY	1.86e-04	11	35	2	PF09815
Domain	LIM	LIMS1 LHX3 LHX4	2.90e-04	69	35	3	PF00412
Domain	-	LIMS1 LHX3 LHX4	3.03e-04	70	35	3	2.10.110.10
Domain	LIM_DOMAIN_2	LIMS1 LHX3 LHX4	3.16e-04	71	35	3	PS50023
Domain	Znf_LIM	LIMS1 LHX3 LHX4	3.16e-04	71	35	3	IPR001781
Domain	LIM_DOMAIN_1	LIMS1 LHX3 LHX4	3.16e-04	71	35	3	PS00478
Domain	LIM	LIMS1 LHX3 LHX4	3.16e-04	71	35	3	SM00132
Domain	zf-C3HC4	RNF121 TRIM39 RNF175 VPS8	7.75e-04	223	35	4	PF00097
Domain	Olfact_rcpt	OR52R1 OR5H2 OR5K2 OR5K1 OR52B6	7.76e-04	393	35	5	IPR000725
Domain	-	RNF121 PIAS4 TRIM39 RNF175 VPS8	1.41e-03	449	35	5	3.30.40.10
Domain	Znf_RING/FYVE/PHD	RNF121 PIAS4 TRIM39 RNF175 VPS8	1.55e-03	459	35	5	IPR013083
Domain	GPS	ADGRG5 PKD1L2	1.84e-03	34	35	2	SM00303
Domain	GPS	ADGRG5 PKD1L2	1.95e-03	35	35	2	PF01825
Domain	GPS	ADGRG5 PKD1L2	2.07e-03	36	35	2	PS50221
Domain	ZF_RING_1	RNF121 TRIM39 RNF175 VPS8	2.07e-03	291	35	4	PS00518
Domain	GPS	ADGRG5 PKD1L2	2.18e-03	37	35	2	IPR000203
Domain	ZF_RING_2	RNF121 TRIM39 RNF175 VPS8	2.25e-03	298	35	4	PS50089
Domain	RING	RNF121 TRIM39 RNF175 VPS8	2.45e-03	305	35	4	SM00184
Domain	Znf_RING	RNF121 TRIM39 RNF175 VPS8	3.11e-03	326	35	4	IPR001841
Domain	Butyrophylin	FSD2 TRIM39	7.61e-03	70	35	2	IPR003879
Domain	GPCR_Rhodpsn_7TM	OR52R1 OR5H2 OR5K2 OR5K1 OR52B6	7.79e-03	670	35	5	IPR017452
Domain	7tm_1	OR52R1 OR5H2 OR5K2 OR5K1 OR52B6	8.13e-03	677	35	5	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR52R1 OR5H2 OR5K2 OR5K1 OR52B6	8.53e-03	685	35	5	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR52R1 OR5H2 OR5K2 OR5K1 OR52B6	8.84e-03	691	35	5	PS50262
Domain	GPCR_Rhodpsn	OR52R1 OR5H2 OR5K2 OR5K1 OR52B6	8.89e-03	692	35	5	IPR000276
Domain	EGF_3	EPGN HYAL2 AREG	9.57e-03	235	35	3	PS50026
Domain	EGF	EPGN HYAL2 AREG	9.57e-03	235	35	3	SM00181
Domain	EGF-like_dom	EPGN HYAL2 AREG	1.12e-02	249	35	3	IPR000742
Domain	SPRY	FSD2 TRIM39	1.16e-02	87	35	2	SM00449
Domain	EGF_1	EPGN HYAL2 AREG	1.19e-02	255	35	3	PS00022
Domain	EGF-like_CS	EPGN HYAL2 AREG	1.27e-02	261	35	3	IPR013032
Domain	EGF_2	EPGN HYAL2 AREG	1.32e-02	265	35	3	PS01186
Domain	SPRY	FSD2 TRIM39	1.34e-02	94	35	2	PF00622
Domain	SPRY_dom	FSD2 TRIM39	1.34e-02	94	35	2	IPR003877
Domain	B30.2/SPRY	FSD2 TRIM39	1.37e-02	95	35	2	IPR001870
Domain	B302_SPRY	FSD2 TRIM39	1.37e-02	95	35	2	PS50188
Domain	Kinase-like_dom	HIPK3 ALPK1 MAP3K6 MAP3K5	1.80e-02	542	35	4	IPR011009
Pathway	REACTOME_EGFR_INTERACTS_WITH_PHOSPHOLIPASE_C_GAMMA	EPGN AREG	1.26e-04	9	27	2	MM14853
Pathway	REACTOME_EGFR_INTERACTS_WITH_PHOSPHOLIPASE_C_GAMMA	EPGN AREG	1.26e-04	9	27	2	M27133
Pathway	REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING	EPGN AREG	2.72e-04	13	27	2	MM14701
Pathway	REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING	EPGN AREG	3.17e-04	14	27	2	M719
Pathway	REACTOME_GAB1_SIGNALOSOME	EPGN AREG	4.72e-04	17	27	2	MM14700
Pathway	REACTOME_GAB1_SIGNALOSOME	EPGN AREG	4.72e-04	17	27	2	M10450
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR52R1 OR5H2 OR5K2 OR5K1 OR52B6	7.63e-04	389	27	5	M14091
Pathway	REACTOME_ESTROGEN_DEPENDENT_NUCLEAR_EVENTS_DOWNSTREAM_OF_ESR_MEMBRANE_SIGNALING	EPGN AREG	9.50e-04	24	27	2	M27952
Pathway	REACTOME_SIGNALING_BY_EGFR_IN_CANCER	EPGN AREG	1.03e-03	25	27	2	M563
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR52R1 OR5H2 OR5K2 OR5K1 OR52B6	1.04e-03	417	27	5	M4072
Pathway	PID_P38_MKK3_6PATHWAY	MAP3K6 MAP3K5	1.12e-03	26	27	2	M20
Pathway	REACTOME_EGFR_DOWNREGULATION	EPGN AREG	1.59e-03	31	27	2	MM14705
Pathway	REACTOME_EGFR_DOWNREGULATION	EPGN AREG	1.59e-03	31	27	2	M16597
Pubmed	Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development.	LHX3 LHX4	1.04e-06	2	36	2	15567726
Pubmed	ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.	MAP3K6 MAP3K5	1.04e-06	2	36	2	19214184
Pubmed	Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons.	LHX3 LHX4	1.04e-06	2	36	2	38970652
Pubmed	Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.	MAP3K6 MAP3K5	1.04e-06	2	36	2	17210579
Pubmed	Amphiregulin exosomes increase cancer cell invasion.	EPGN AREG	1.04e-06	2	36	2	21514161
Pubmed	MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5.	MAP3K6 MAP3K5	1.04e-06	2	36	2	9875215
Pubmed	Molecular cloning and expression analysis of the mouse Spot-2 gene in pituitary development.	LHX3 LHX4	1.04e-06	2	36	2	12684778
Pubmed	The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.	MAP3K6 MAP3K5	3.12e-06	3	36	2	26243192
Pubmed	ASK family kinases mediate cellular stress and redox signaling to circadian clock.	MAP3K6 MAP3K5	3.12e-06	3	36	2	29555767
Pubmed	Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta.	LHX3 LHX4	3.12e-06	3	36	2	18425848
Pubmed	Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases.	MAP3K6 MAP3K5	3.12e-06	3	36	2	32156783
Pubmed	ASK1/2 signaling promotes inflammation in a mouse model of neutrophilic dermatosis.	MAP3K6 MAP3K5	3.12e-06	3	36	2	29629899
Pubmed	Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors.	LHX3 LHX4	3.12e-06	3	36	2	10788441
Pubmed	β-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress.	MAP3K6 MAP3K5	6.24e-06	4	36	2	30031111
Pubmed	ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease.	MAP3K6 MAP3K5	6.24e-06	4	36	2	18327563
Pubmed	Dual engagement of 14-3-3 proteins controls signal relay from ASK2 to the ASK1 signalosome.	MAP3K6 MAP3K5	6.24e-06	4	36	2	19935702
Pubmed	Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification.	LHX3 LHX4	6.24e-06	4	36	2	22025611
Pubmed	Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress.	MAP3K6 MAP3K5	1.04e-05	5	36	2	11689443
Pubmed	Homeodomain transcription factors in the development of subsets of hindbrain reticulospinal neurons.	LHX3 LHX4	1.04e-05	5	36	2	15607939
Pubmed	Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion.	LHX3 LHX4	1.56e-05	6	36	2	20534763
Pubmed	The human olfactory receptor gene family.	OR52R1 OR5H2 OR5K2 OR5K1 OR52B6 OR5H8	1.81e-05	541	36	6	14983052
Pubmed	ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming.	MAP3K6 MAP3K5	2.18e-05	7	36	2	29353059
Pubmed	Curly bare (cub), a new mouse mutation on chromosome 11 causing skin and hair abnormalities, and a modifier gene (mcub) on chromosome 5.	EPGN AREG	2.18e-05	7	36	2	12573256
Pubmed	Borjeson-Forssman-Lehmann syndrome: a novel pituitary phenotype due to mutation in a novel gene.	LHX3 LHX4	2.18e-05	7	36	2	14714741
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR52R1 OR5H2 OR5K2 OR5K1 OR5H8	2.55e-05	340	36	5	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR52R1 OR5H2 OR5K2 OR5K1 OR5H8	2.55e-05	340	36	5	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR52R1 OR5H2 OR5K2 OR5K1 OR5H8	2.66e-05	343	36	5	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR52R1 OR5H2 OR5K2 OR5K1 OR5H8	2.77e-05	346	36	5	14611657
Pubmed	Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin.	EPGN AREG	2.91e-05	8	36	2	24825892
Pubmed	Formation of Rathke's pouch requires dual induction from the diencephalon.	LHX3 LHX4	3.73e-05	9	36	2	9806931
Pubmed	Lhx4 deficiency: increased cyclin-dependent kinase inhibitor expression and pituitary hypoplasia.	LHX3 LHX4	5.70e-05	11	36	2	25668206
Pubmed	Expression of Dlx and Lhx family homeobox genes in fetal thymus and thymocytes.	LHX3 LHX4	6.83e-05	12	36	2	15053981
Pubmed	Specification of pituitary cell lineages by the LIM homeobox gene Lhx3.	LHX3 LHX4	6.83e-05	12	36	2	8638120
Pubmed	Molecular basis of pituitary dysfunction in mouse and human.	LHX3 LHX4	6.83e-05	12	36	2	11420609
Pubmed	An EGFR-ERK-SOX9 signaling cascade links urothelial development and regeneration to cancer.	EPGN AREG	8.07e-05	13	36	2	21512138
Pubmed	LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons.	LHX3 LHX4	8.07e-05	13	36	2	9865699
Pubmed	Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.	LHX3 LHX4	1.08e-04	15	36	2	9230312
Pubmed	MAP3Ks as central regulators of cell fate during development.	MAP3K6 MAP3K5	1.08e-04	15	36	2	18855897
Pubmed	Multistep control of pituitary organogenesis.	LHX3 LHX4	1.08e-04	15	36	2	9388186
Pubmed	Expression of LIM-homeodomain transcription factors in the developing and mature mouse retina.	LHX3 LHX4	1.24e-04	16	36	2	24333658
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	FSD2 LIMS1 IGBP1 UPF2 MAP3K5	1.53e-04	497	36	5	23414517
Pubmed	Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis.	LHX3 LHX4	1.58e-04	18	36	2	10499586
Pubmed	FOXL2 in the pituitary: molecular, genetic, and developmental analysis.	LHX3 LHX4	1.76e-04	19	36	2	16840539
Pubmed	Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity.	LHX3 LHX4	1.96e-04	20	36	2	10482234
Pubmed	Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia.	LHX3 LHX4	1.96e-04	20	36	2	12183375
Pubmed	Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation.	LHX3 LHX4	2.38e-04	22	36	2	8565076
Pubmed	Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.	EPGN AREG	2.83e-04	24	36	2	24043783
Pubmed	LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth.	LHX3 LHX4	3.08e-04	25	36	2	19304889
Pubmed	Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.	OR5H2 OR5H8	3.60e-04	27	36	2	32061665
Pubmed	Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons.	LHX3 ZBTB7C	3.60e-04	27	36	2	24496616
Pubmed	Blimp1 suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development.	LHX3 LHX4	5.39e-04	33	36	2	20463215
Pubmed	Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP.	LHX3 LHX4	5.39e-04	33	36	2	22844247
Pubmed	Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin.	EPGN AREG	6.07e-04	35	36	2	16452166
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	RNF121 FSD2 LIMS1 RGSL1 XKRX	6.69e-04	686	36	5	29987050
Pubmed	Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor.	LHX3 LHX4	1.00e-03	45	36	2	23193182
Interaction	ZNF354C interactions	TRIM39 LHX3 LHX4	1.29e-05	29	32	3	int:ZNF354C
Interaction	LIMD1 interactions	HIPK3 IGBP1 MAP3K6 BICD1	4.30e-05	124	32	4	int:LIMD1
Cytoband	Ensembl 112 genes in cytogenetic band chr3q11	OR5H2 OR5K2 OR5K1 OR5H8	9.79e-08	54	36	4	chr3q11
Cytoband	3q12.1	OR5H2 OR5H8	1.24e-04	21	36	2	3q12.1
Cytoband	3q11.2	OR5K2 OR5K1	1.92e-04	26	36	2	3q11.2
Cytoband	4q13.3	EPGN AREG	5.05e-04	42	36	2	4q13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr4q13	EPGN AREG	6.78e-03	157	36	2	chr4q13
Cytoband	Ensembl 112 genes in cytogenetic band chr1q25	RGSL1 LHX4	7.64e-03	167	36	2	chr1q25
Cytoband	11p15.4	OR52R1 OR52B6	1.08e-02	200	36	2	11p15.4
GeneFamily	Olfactory receptors, family 5	OR5H2 OR5K2 OR5K1 OR5H8	2.19e-05	112	27	4	152
GeneFamily	Blood group antigens\|XK related family	XKRX XKRY	1.17e-04	11	27	2	955
GeneFamily	LIM class homeoboxes	LHX3 LHX4	1.40e-04	12	27	2	522
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	MAP3K6 MAP3K5	5.81e-04	24	27	2	654
GeneFamily	Olfactory receptors, family 52	OR52R1 OR52B6	2.42e-03	49	27	2	165
GeneFamily	Ring finger proteins	RNF121 TRIM39 RNF175	7.77e-03	275	27	3	58
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPGN MAP3K6 XKRX IL17RB	3.99e-06	133	36	4	f7d0763b5eec2db33044d6850fd57462494038c1
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-immature_innate_lymphoid_cell-Ly6g5b+_T\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRG5 RGSL1 XKRX IL17RB	1.13e-05	173	36	4	0a355386210a13927ea29b10b64cb059459952d4
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-immature_innate_lymphoid_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRG5 RGSL1 XKRX IL17RB	1.13e-05	173	36	4	3678b300cad4effd7f49bfb043305ed512693848
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Vein\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZBTB7C MAP3K6 HYAL2 BICD1	1.70e-05	192	36	4	717f3d3bbee4d0f64ba1341ee2b00a407ba1e0f3
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-ILC\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ADGRG5 FSD2 EPGN AREG	1.84e-05	196	36	4	1cc2b11764584129703ec61965e8ec4e051464e7
Disease	Combined pituitary hormone deficiencies, genetic form	LHX3 LHX4	1.29e-05	5	34	2	cv:C4273747
Disease	amphetamine abuse (implicated_via_orthology)	MAP3K6 MAP3K5	1.93e-05	6	34	2	DOID:670 (implicated_via_orthology)
Disease	panhypopituitarism (is_implicated_in)	LHX3 LHX4	2.70e-05	7	34	2	DOID:9410 (is_implicated_in)
Disease	Diabetes Mellitus	ALPK1 MAP3K5	6.25e-04	32	34	2	C0011849
Disease	susceptibility to shingles measurement	TRIM39 ZBTB7C	3.94e-03	81	34	2	EFO_0008401
Disease	Alzheimer disease, APOE carrier status	OR5K2 OR5K1	5.72e-03	98	34	2	EFO_0007659, MONDO_0004975
Disease	C-X-C motif chemokine 10 measurement	EPGN AREG	7.02e-03	109	34	2	EFO_0008056

Protein segments in the cluster

Peptide	Gene	Start	Entry
FSHLCLEDHNSYCIN	EPGN	56	Q6UW88
QNFCIHGECKYIEHL	AREG	151	P15514
FSEELAQLYHHVCLC	BICD1	511	Q96G01
YFFNNQHVECNEICH	ALPK1	1216	Q96QP1
LVFCGLNHINHFYCD	OR5K2	166	Q8NHB8
HFCHDLVSLCNFHNY	GLS	516	O94925
LTFCNSNIIHHFYCD	OR5H8	166	P0DN80
ADIDHLQTHFRCQCY	HYAL2	416	Q12891
HTICYFTEFLQNHCR	IL17RB	346	Q9NRM6
CDVAEQHNVCFHYTF	MAP3K6	306	O95382
NYLTQCHCYHVAEFE	IGBP1	111	P78318
HYCQINIIAHTFCEH	OR52B6	186	Q8NGF0
LTFCNSNIIHHFYCD	OR5H2	171	Q8NGV7
AQDFVYHLHCFACVV	LHX3	106	Q9UBR4
QDFVYHLHCFACIIC	LHX4	106	Q969G2
LHVCIQEFCAALFYL	NLRP4	451	Q96MN2
AYECFQHRNHTCLVF	HIPK3	261	Q9H422
LVFCGSNHINHFYCD	OR5K1	166	Q8NHB7
YQTHCLCNHLTFFGS	PKD1L2	1306	Q7Z442
QYHACLIQVFFIHAF	OR52R1	96	Q8NGF1
AANHHYALDLICQRC	MCF2	286	P10911
HLYHLCVQAQDFCFL	GBF1	1181	Q92538
CAVHLCSLFHQRYAD	UPF2	221	Q9HAU5
CCFLYVLHNSDDFQI	MAP3K5	621	Q99683
LCFHYILCQEFISFI	RGSL1	81	A5PLK6
LCPQHHEALSLFCYE	TRIM39	106	Q9HCM9
LYTFSCQLHEFVHPC	FSD2	711	A1L4K1
IVFSCGHLYHSFCLQ	VPS8	1276	Q8N3P4
ETHYNQLFGDVCFHC	LIMS1	241	P48059
HSQVLCRCNHLTYFA	ADGRG5	216	Q8IZF4
YLNHASICCHQFSCL	XKRY	116	O14609
NTYQLSCNHVFHEFC	RNF175	246	Q8N4F7
TYRLSCNHVFHEFCI	RNF121	246	Q9H920
TCAHLQCFDAVFYLQ	PIAS4	341	Q8N2W9
LCIHCNAKFVHNYDL	ZBTB7C	421	A1YPR0
LFTHNVVDYLHCVCC	XKRX	411	Q6PP77