Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GTPase activator activity	ARHGAP42 RGPD4 RANBP2 ARHGAP24 ARHGAP23 AGAP11 AGAP9	8.51e-05	279	75	7	GO:0005096
GeneOntologyBiologicalProcess	sebum secreting cell proliferation	GATA6 PRDM1	3.60e-05	3	72	2	GO:1990654
GeneOntologyBiologicalProcess	TORC1 signaling	USP6 SZT2 USP32 CARD11 DYRK3	3.97e-05	109	72	5	GO:0038202
GeneOntologyBiologicalProcess	NLS-bearing protein import into nucleus	RGPD4 KPNA7 RANBP2	4.46e-05	20	72	3	GO:0006607
GeneOntologyCellularComponent	super elongation complex	AFF3 AFF1	1.84e-04	6	74	2	GO:0032783
GeneOntologyCellularComponent	cytoplasmic periphery of the nuclear pore complex	RGPD4 RANBP2	3.41e-04	8	74	2	GO:1990723
GeneOntologyCellularComponent	nuclear pore cytoplasmic filaments	RGPD4 RANBP2	5.46e-04	10	74	2	GO:0044614
Domain	TF_AF4/FMR2	AFF3 AFF1	9.75e-05	4	76	2	IPR007797
Domain	AF-4	AFF3 AFF1	9.75e-05	4	76	2	PF05110
Domain	DUF3585	MICALL1 MICAL3	3.39e-04	7	76	2	IPR022735
Domain	DUF3585	MICALL1 MICAL3	3.39e-04	7	76	2	PF12130
Domain	Ran_BP1	RGPD4 RANBP2	1.05e-03	12	76	2	PF00638
Domain	RANBD1	RGPD4 RANBP2	1.05e-03	12	76	2	PS50196
Domain	-	ARHGAP42 RGPD4 RANBP2 ARHGAP24 ARHGAP23 AGAP11 AGAP9	1.06e-03	391	76	7	2.30.29.30
Domain	RanBD	RGPD4 RANBP2	1.24e-03	13	76	2	SM00160
Domain	Ran_bind_dom	RGPD4 RANBP2	1.24e-03	13	76	2	IPR000156
Domain	PH_dom-like	ARHGAP42 RGPD4 RANBP2 ARHGAP24 ARHGAP23 AGAP11 AGAP9	1.73e-03	426	76	7	IPR011993
Domain	RhoGAP	ARHGAP42 ARHGAP24 ARHGAP23	2.06e-03	62	76	3	SM00324
Domain	RhoGAP	ARHGAP42 ARHGAP24 ARHGAP23	2.16e-03	63	76	3	PF00620
Domain	UBA-like	SQSTM1 UBXN7 TNRC6B	2.26e-03	64	76	3	IPR009060
Domain	RHOGAP	ARHGAP42 ARHGAP24 ARHGAP23	2.26e-03	64	76	3	PS50238
Domain	RhoGAP_dom	ARHGAP42 ARHGAP24 ARHGAP23	2.26e-03	64	76	3	IPR000198
Domain	-	ARHGAP42 ARHGAP24 ARHGAP23	2.26e-03	64	76	3	1.10.555.10
Domain	Zinc_finger_PHD-type_CS	TAF3 KDM5A NFX1	2.36e-03	65	76	3	IPR019786
Domain	CH	MICALL1 MICAL3 SPECC1	2.36e-03	65	76	3	SM00033
Domain	CH	MICALL1 MICAL3 SPECC1	2.91e-03	70	76	3	PF00307
Domain	-	MICALL1 MICAL3 SPECC1	3.03e-03	71	76	3	1.10.418.10
Domain	CH	MICALL1 MICAL3 SPECC1	3.28e-03	73	76	3	PS50021
Domain	CH-domain	MICALL1 MICAL3 SPECC1	3.54e-03	75	76	3	IPR001715
Domain	Znf_C2H2_jaz	ZNF385D ZNF804B	3.58e-03	22	76	2	IPR022755
Domain	zf-C2H2_jaz	ZNF385D ZNF804B	3.58e-03	22	76	2	PF12171
Domain	Znf_PHD-finger	TAF3 KDM5A NFX1	4.10e-03	79	76	3	IPR019787
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MICALL1 PCNX2 MYCL RANBP10 SZT2 FURIN GTSE1 NFX1 COBL MICAL3 ZC3H7B MBD5 CIC HIRA	1.52e-07	1105	78	14	35748872
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	CEP350 SQSTM1 TNRC6B QSER1 ZC3H7B YES1 CIC	1.26e-06	242	78	7	34011540
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	MICALL1 CEP350 RANBP2 CENPE GTSE1 NFX1 TNRC6B COBL MICAL3 TMEM131 YES1	3.16e-06	853	78	11	28718761
Pubmed	Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.	RGPD4 RANBP2 LAMA1	4.84e-06	15	78	3	14697343
Pubmed	AT1-receptor response to non-saturating Ang-II concentrations is amplified by calcium channel blockers.	CACNA1C AGTR1	4.97e-06	2	78	2	28514967
Pubmed	USP32 is an active, membrane-bound ubiquitin protease overexpressed in breast cancers.	USP6 USP32	4.97e-06	2	78	2	20549504
Pubmed	Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3.	FURIN TMPRSS2	4.97e-06	2	78	2	9325052
Pubmed	DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia.	EPOR DYRK3	4.97e-06	2	78	2	18854306
Pubmed	Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence.	SQSTM1 HIRA	4.97e-06	2	78	2	39178863
Pubmed	Regulation of Stress Responses and Translational Control by Coronavirus.	FURIN TMPRSS2	4.97e-06	2	78	2	27384577
Pubmed	Association of AFF1 rs340630 and AFF3 rs10865035 polymorphisms with systemic lupus erythematosus in a Chinese population.	AFF3 AFF1	4.97e-06	2	78	2	22983539
Pubmed	Furin Egress from the TGN is Regulated by Membrane-Associated RING-CH Finger (MARCHF) Proteins and Ubiquitin-Specific Protease 32 (USP32) via Nondegradable K33-Polyubiquitination.	FURIN USP32	4.97e-06	2	78	2	39031635
Pubmed	Dual-specificity kinase DYRK3 phosphorylates p62 at the Thr-269 residue and promotes melanoma progression.	SQSTM1 DYRK3	4.97e-06	2	78	2	38519031
Pubmed	TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells.	FURIN TMPRSS2	4.97e-06	2	78	2	32703818
Pubmed	Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity.	FURIN TMPRSS2	4.97e-06	2	78	2	35343766
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	MICALL1 CEP350 RANBP2 ATXN2 KDM5A SQSTM1 NFX1 TNRC6B TMEM131 HIRA	5.05e-06	724	78	10	36232890
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	SZT2 LAMA1 SENP6 COBL CARD11 SPECC1	7.64e-06	208	78	6	33230847
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	CEP350 USP6 STAC2 ATXN2 TNRC6B ZC3H7B BEND2 CIC PRDM1	8.97e-06	608	78	9	16713569
Pubmed	ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain.	FURIN TMPRSS2	1.49e-05	3	78	2	32691890
Pubmed	Assessing COVID-19 susceptibility through analysis of the genetic and epigenetic diversity of ACE2-mediated SARS-CoV-2 entry.	FURIN TMPRSS2	1.49e-05	3	78	2	33243086
Pubmed	Expression profile of SARS-CoV-2 cellular entry proteins in normal oral mucosa and oral squamous cell carcinoma.	FURIN TMPRSS2	1.49e-05	3	78	2	34726347
Pubmed	TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction.	FURIN TMPRSS2	1.49e-05	3	78	2	34807954
Pubmed	Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance.	SQSTM1 FHOD3	1.49e-05	3	78	2	21149568
Pubmed	IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein.	SCHIP1 IQCJ-SCHIP1	1.49e-05	3	78	2	17045569
Pubmed	Bioinformatics Analysis of Allele Frequencies and Expression Patterns of ACE2, TMPRSS2 and FURIN in Different Populations and Susceptibility to SARS-CoV-2.	FURIN TMPRSS2	1.49e-05	3	78	2	34356057
Pubmed	Tobacco Smoking Increases the Lung Gene Expression of ACE2, the Receptor of SARS-CoV-2.	FURIN TMPRSS2	1.49e-05	3	78	2	32329629
Pubmed	Erythropoietin-dependent erythropoiesis: New insights and questions.	EPOR DYRK3	1.49e-05	3	78	2	16524748
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	RGPD4 RANBP2 GTSE1 QSER1 HIRA	2.01e-05	146	78	5	23892456
Pubmed	Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice.	CYB5B USP6 USP32 TNRC6B	2.39e-05	74	78	4	23604909
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PCNX2 CACNA1C ATXN2 MYT1 AFF3 TNRC6B TMPRSS2 COBL AFF1 MICAL3 QSER1 MBD5 INKA2	2.54e-05	1489	78	13	28611215
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	RANBP2 ATXN2 SQSTM1 NFX1 TNRC6B TMEM131	2.88e-05	263	78	6	34702444
Pubmed	Systematic Investigation of SARS-CoV-2 Receptor Protein Distribution along Viral Entry Routes in Humans.	FURIN TMPRSS2	2.97e-05	4	78	2	35038715
Pubmed	Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production.	CARD11 PRDM1	2.97e-05	4	78	2	23027925
Pubmed	COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells.	FURIN TMPRSS2	2.97e-05	4	78	2	32867305
Pubmed	Schwannomin-interacting Protein 1 Isoform IQCJ-SCHIP1 Is a Multipartner Ankyrin- and Spectrin-binding Protein Involved in the Organization of Nodes of Ranvier.	SCHIP1 IQCJ-SCHIP1	2.97e-05	4	78	2	27979964
Pubmed	Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice.	AFF3 AFF1	2.97e-05	4	78	2	11923441
Pubmed	PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins.	TLE2 PRDM1	2.97e-05	4	78	2	9887105
Pubmed	An oligodendrocyte enhancer in a phylogenetically conserved intron region of the mammalian myelin gene Opalin.	MYT1 TLL2	2.97e-05	4	78	2	17442045
Pubmed	Autophagy exacerbates electrical remodeling in atrial fibrillation by ubiquitin-dependent degradation of L-type calcium channel.	CACNA1C SQSTM1	2.97e-05	4	78	2	30158642
Pubmed	CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.	SCHIP1 IQCJ-SCHIP1	4.94e-05	5	78	2	25950943
Pubmed	The Tre2 (USP6) oncogene is a hominoid-specific gene.	USP6 USP32	4.94e-05	5	78	2	12604796
Pubmed	Interaction of SQSTM1 with the motor protein dynein--SQSTM1 is required for normal dynein function and trafficking.	DNAI1 SQSTM1	4.94e-05	5	78	2	25015291
Pubmed	Genetic analysis of alcohol intake in recombinant inbred and congenic strains derived from A/J and C57BL/6J progenitors.	AGTR1 CHRNA4	4.94e-05	5	78	2	16104380
Pubmed	MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.	MICALL1 MICAL3	4.94e-05	5	78	2	12110185
Pubmed	Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late component of nodes of Ranvier and axon initial segments.	SCHIP1 IQCJ-SCHIP1	4.94e-05	5	78	2	18550753
Pubmed	Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties.	GATA6 PRDM1	4.94e-05	5	78	2	28504705
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	RGPD4 RANBP10 RANBP2 ATXN2 NFX1	5.76e-05	182	78	5	32239614
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	RGPD4 RANBP10 RANBP2 ARHGAP24 CENPE ATXN2 KDM5A TNRC6B QSER1 HIRA	5.80e-05	963	78	10	28671696
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MICALL1 RANBP2 TAF3 KDM5A GTSE1 SENP6 AFF1 MICAL3 CIC	5.92e-05	774	78	9	15302935
Pubmed	Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2.	FURIN TMPRSS2	7.40e-05	6	78	2	36071039
Pubmed	Human transcription factor protein interaction networks.	TAF3 ATXN2 KDM5A SQSTM1 UBXN7 NFYC GATA6 TNRC6B QSER1 CIC HIRA PRDM1	7.81e-05	1429	78	12	35140242
Pubmed	Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor.	MYCL NFYC	1.04e-04	7	78	2	8921405
Pubmed	Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.	RGPD4 RANBP2	1.04e-04	7	78	2	21205196
Pubmed	Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.	RGPD4 RANBP2	1.04e-04	7	78	2	18949001
Pubmed	Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.	RGPD4 RANBP2	1.04e-04	7	78	2	25187515
Pubmed	Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.	RGPD4 RANBP2	1.04e-04	7	78	2	9037092
Pubmed	Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.	RGPD4 RANBP2	1.04e-04	7	78	2	8603673
Pubmed	Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).	RGPD4 RANBP2	1.04e-04	7	78	2	26632511
Pubmed	Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.	RGPD4 RANBP2	1.04e-04	7	78	2	24403063
Pubmed	Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.	RGPD4 RANBP2	1.04e-04	7	78	2	23818861
Pubmed	Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.	RGPD4 RANBP2	1.04e-04	7	78	2	11353387
Pubmed	Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.	RGPD4 RANBP2	1.04e-04	7	78	2	30944974
Pubmed	Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.	RGPD4 RANBP2	1.04e-04	7	78	2	38838144
Pubmed	Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.	RGPD4 RANBP2	1.04e-04	7	78	2	23536549
Pubmed	Retina-specifically expressed novel subtypes of bovine cyclophilin.	RGPD4 RANBP2	1.04e-04	7	78	2	7559465
Pubmed	A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13.	CACNA1C AKR1D1	1.04e-04	7	78	2	12562828
Pubmed	Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.	RGPD4 RANBP2	1.04e-04	7	78	2	17372272
Pubmed	Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.	RGPD4 RANBP2	1.04e-04	7	78	2	38657106
Pubmed	Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.	RGPD4 RANBP2	1.04e-04	7	78	2	12191015
Pubmed	Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	RGPD4 RANBP2	1.04e-04	7	78	2	22821000
Pubmed	Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.	RGPD4 RANBP2	1.04e-04	7	78	2	20682751
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	USP6 SQSTM1 UBXN7 USP32 LAMA1 NFX1 RSC1A1	1.05e-04	481	78	7	28190767
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	CEP350 SQSTM1 TNRC6B COBL MICAL3	1.10e-04	209	78	5	36779422
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	RANBP2 ATXN2 KDM5A SQSTM1 NFX1 TNRC6B ZC3H7B YES1 SPECC1 SPTY2D1 CIC HIRA	1.21e-04	1497	78	12	31527615
Pubmed	The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.	RGPD4 RANBP2	1.38e-04	8	78	2	22262462
Pubmed	The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.	RGPD4 RANBP2	1.38e-04	8	78	2	21670213
Pubmed	Imaging within single NPCs reveals NXF1's role in mRNA export on the cytoplasmic side of the pore.	RANBP2 NFX1	1.38e-04	8	78	2	31375530
Pubmed	Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.	RGPD4 RANBP2	1.38e-04	8	78	2	28745977
Pubmed	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.	RGPD4 RANBP2	1.38e-04	8	78	2	27412403
Pubmed	Mice lacking Ran binding protein 1 are viable and show male infertility.	RGPD4 RANBP2	1.38e-04	8	78	2	21310149
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	PCNX2 TLE2 AGAP11 AGAP9	1.39e-04	116	78	4	30652415
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	RANBP2 GTSE1 AFF3 SENP6 SPTY2D1	1.46e-04	222	78	5	37071664
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP11 AGAP9	1.77e-04	9	78	2	12640130
Pubmed	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.	RGPD4 RANBP2	1.77e-04	9	78	2	18394993
Pubmed	The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.	RGPD4 RANBP2	1.77e-04	9	78	2	11553612
Pubmed	The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.	RGPD4 RANBP2	1.77e-04	9	78	2	10601307
Pubmed	The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.	RGPD4 RANBP2	1.77e-04	9	78	2	9733766
Pubmed	Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.	RGPD4 RANBP2	1.77e-04	9	78	2	28100513
Pubmed	Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.	RGPD4 RANBP2	1.77e-04	9	78	2	28877029
Pubmed	Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.	RGPD4 RANBP2	1.77e-04	9	78	2	17887960
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MICALL1 SZT2 UBXN7 SENP6 AGAP11 AGAP9 ZC3H7B	1.88e-04	529	78	7	14621295
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	CYB5B USP6 USP32 TNRC6B AGAP11 AGAP9 MBD5	2.04e-04	536	78	7	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	CYB5B USP6 USP32 TNRC6B AGAP11 AGAP9 MBD5	2.09e-04	538	78	7	10512203
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP11 AGAP9	2.21e-04	10	78	2	20664521
Pubmed	Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal.	LAMA1 GATA6	2.21e-04	10	78	2	20123909
Pubmed	Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.	RGPD4 RANBP2	2.21e-04	10	78	2	8857542
Pubmed	The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.	RGPD4 RANBP2	2.21e-04	10	78	2	27160050
Pubmed	Parkin ubiquitinates and promotes the degradation of RanBP2.	RGPD4 RANBP2	2.21e-04	10	78	2	16332688
Pubmed	Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.	RGPD4 RANBP2	2.21e-04	10	78	2	21859863
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP11 AGAP9	2.70e-04	11	78	2	15381706
Cytoband	2q12.3	RGPD4 RANBP2	3.81e-04	17	78	2	2q12.3
Cytoband	Ensembl 112 genes in cytogenetic band chr22q13	MICALL1 GTSE1 TNRC6B ZC3H7B	2.46e-03	330	78	4	chr22q13
GeneFamily	AF4/FMR2 family\|Super elongation complex	AFF3 AFF1	4.30e-05	4	49	2	1145
GeneFamily	AF4/FMR2 family\|Super elongation complex	AFF3 AFF1	2.56e-04	9	49	2	1280
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP42 ARHGAP24 ARHGAP23	3.35e-04	50	49	3	721
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP11 AGAP9	9.53e-04	17	49	2	1291
GeneFamily	PHD finger proteins	TAF3 KDM5A NFX1	1.86e-03	90	49	3	88
GeneFamily	Ataxins\|Trinucleotide repeat containing	ATXN2 TNRC6B	2.07e-03	25	49	2	775
GeneFamily	WD repeat domain containing\|Caspase recruitment domain containing\|Apoptosome	CARD6 CARD11	2.98e-03	30	49	2	959
GeneFamily	ArfGAPs	AGAP11 AGAP9	3.60e-03	33	49	2	395
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RGPD4 RANBP2 ZC3H7B	3.73e-03	115	49	3	769
GeneFamily	Ubiquitin specific peptidases	USP6 USP32	1.01e-02	56	49	2	366
GeneFamily	LIM domain containing	MICALL1 MICAL3	1.12e-02	59	49	2	1218
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	CEP350 USP6 SCHIP1 CENPE ATXN2 KDM5A NFYC AFF1 MICAL3 TMEM131 HIRA	1.16e-07	466	77	11	M13522
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	CEP350 USP6 RANBP2 SCHIP1 CENPE ATXN2 KDM5A UBXN7 NFYC AFF1 MICAL3 TMEM131 HIRA	1.17e-06	856	77	13	M4500
Coexpression	FISCHER_DIRECT_P53_TARGETS_META_ANALYSIS	MICALL1 ARHGAP42 TMEM131 NOPCHAP1 MBD5 INKA2 DYRK3 PRDM1	3.71e-06	311	77	8	M61
Coexpression	GSE4748_LPS_VS_LPS_AND_CYANOBACTERIUM_LPSLIKE_STIM_DC_3H_UP	CEP350 RANBP2 KDM5A UBXN7 TNRC6B DNAJB14	2.33e-05	194	77	6	M6493
Coexpression	GSE40273_XBP1_KO_VS_WT_TREG_DN	MICALL1 CEP350 RITA1 TNRC6B TMEM131 DYRK3	2.69e-05	199	77	6	M9124
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D175\|Adult / Lineage, Cell type, age group and donor	ZNF385D CACNA1C STAC2 FHOD3 IQCJ-SCHIP1	1.13e-05	167	78	5	c4e321bb87512ea839f324c92c0f1afea891483f
ToppCell	Control-B_cells-Activated_B_cells\|Control / group, cell type (main and fine annotations)	ARHGAP24 AFF3 TNRC6B CARD11 MICAL3	1.16e-05	168	78	5	a7159a35fe37f8c241cf8d391debe271e0698105
ToppCell	Control-Lymphoid-pDC\|Control / Condition, Lineage and Cell class	MYCL SCHIP1 ARHGAP23 AFF3 CARD11	1.45e-05	176	78	5	5de16ff65476bde8b23322a44e11412e14f1bafe
ToppCell	COVID-19-B_cells-Activated_B_cells\|COVID-19 / group, cell type (main and fine annotations)	ARHGAP24 MYT1 AFF3 CARD11 MICAL3	1.49e-05	177	78	5	653bb62a3744d4024ab3186ee01d410ed62832a6
ToppCell	IPF-Lymphoid-B\|World / Disease state, Lineage and Cell class	ARHGAP24 AFF3 TNRC6B CARD11 MICAL3	1.62e-05	180	78	5	30f9398c9b784f49470847a025bac90687e997a1
ToppCell	Control-Lymphoid-B\|World / Disease state, Lineage and Cell class	ARHGAP24 AFF3 TNRC6B CARD11 MICAL3	1.66e-05	181	78	5	9124f1a610cfc3355ad87921cd3eb5346956475d
ToppCell	nucseq-Immune-Lymphocytic_B-Lymphocytic_B-B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARHGAP24 AFF3 TNRC6B CARD11 MICAL3	1.66e-05	181	78	5	8d8cc4dae2c8bd5f4b1c159f2a52edc4c9449c86
ToppCell	IPF-Lymphoid-B\|IPF / Disease state, Lineage and Cell class	ARHGAP24 AFF3 TNRC6B CARD11 MICAL3	1.75e-05	183	78	5	e37d2c015c34471a8a54a0299e94b0371e1ada5a
ToppCell	nucseq-Immune-Lymphocytic_B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARHGAP24 AFF3 TNRC6B CARD11 MICAL3	1.80e-05	184	78	5	911658e7bb499c1bbc8419eec8ff88729bc39a75
ToppCell	Control-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	MYCL AFF3 CARD11 NOPCHAP1 SPECC1	1.80e-05	184	78	5	c6affa0b12510363258f65e46bf2d47bf4a8e75f
ToppCell	Control-Lymphoid-B\|Control / Disease state, Lineage and Cell class	ARHGAP24 AFF3 TNRC6B CARD11 MICAL3	1.80e-05	184	78	5	de0294f879268bfd68e91adcc2adba211d221b7a
ToppCell	nucseq-Immune-Lymphocytic_B-Lymphocytic_B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARHGAP24 AFF3 TNRC6B CARD11 MICAL3	1.80e-05	184	78	5	942b58ae7172bb5f97e55b032db9329d161854af
ToppCell	Fetal_29-31_weeks-Immune-enucleated_erythrocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	RANBP10 USP32 MICAL3 SPECC1 DYRK3	1.84e-05	185	78	5	e8f7da9641b6cf1db1093b4f301ce828fd3a529c
ToppCell	COPD-Lymphoid-B\|COPD / Disease state, Lineage and Cell class	ARHGAP24 AFF3 TNRC6B CARD11 MICAL3	1.84e-05	185	78	5	925e79c35c381dd44ec5fb921dca09ce43140135
ToppCell	COPD-Lymphoid-B\|World / Disease state, Lineage and Cell class	ARHGAP24 AFF3 TNRC6B CARD11 MICAL3	1.84e-05	185	78	5	22891ed75e25ef30dfa541cb82d85e08ce07e7d9
ToppCell	Immune-enucleated_erythrocyte\|World / Lineage, Cell type, age group and donor	EPOR MYT1 MICAL3 SPECC1 DYRK3	1.89e-05	186	78	5	f9d5ec5cc8fd6e63bf25abe390307ec8a4a2d5a3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 ZNF804B COBL MICAL3 IQCJ-SCHIP1	1.89e-05	186	78	5	f28d72b47624b69a580b4429e2be560a26898591
ToppCell	Control-Myeloid-cDC1\|Control / Disease state, Lineage and Cell class	MYCL AFF3 CARD11 NOPCHAP1 SPECC1	1.89e-05	186	78	5	b05c394aa3573ba855abc3066739ca193883b0c3
ToppCell	Fetal_29-31_weeks-Immune-enucleated_erythrocyte\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	EPOR MYT1 MICAL3 SPECC1 DYRK3	2.04e-05	189	78	5	1900e574870fc647bfa11c732a72f3d38aab717c
ToppCell	COPD-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	MYCL AFF3 CARD11 NOPCHAP1 SPECC1	2.15e-05	191	78	5	3480e6d27dd4291765bbbb2acdb6a2e4f02c8085
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CENPE GTSE1 ZNF804B LAMA1 TMPRSS2	2.20e-05	192	78	5	25378b5e4b0cea8415ff125783511fc25a56fc00
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	CEP350 RANBP2 USP32 AFF1 SPTY2D1	2.26e-05	193	78	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARHGAP24 AFF3 MICAL3 NOPCHAP1 DNAJB14	2.32e-05	194	78	5	5cd72330c9d9bb21b6c9d5d35085eade101486d1
ToppCell	Control-Multiplet\|Control / Disease state, Lineage and Cell class	AFF3 GATA6 TMPRSS2 COBL YES1	2.37e-05	195	78	5	618900c80bea09d46dad3f741bd1bff8bf0a64ee
ToppCell	Control-Multiplet-Multiplet\|Control / Disease state, Lineage and Cell class	AFF3 GATA6 TMPRSS2 COBL YES1	2.37e-05	195	78	5	06ac685855e14e4dd2cbe6d0e73f894f2eeff91f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 AGTR1 AFF3 GATA6 SPECC1	2.43e-05	196	78	5	2b36b9a40fe415917afccff99ad9c3474e087d0d
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1C STAC2 LAMA1 FHOD3 IQCJ-SCHIP1	2.49e-05	197	78	5	f0475ad9c09c6da418dba17d3d3c1aaa2ef9ab4e
ToppCell	severe-pDC\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MYCL SCHIP1 AFF3 COBL NOPCHAP1	2.55e-05	198	78	5	22da4a29b9ff8b94d98bc69b4632a2a58d5dd9e6
ToppCell	severe-pDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MYCL SCHIP1 AFF3 COBL NOPCHAP1	2.55e-05	198	78	5	3c4820a8391088682fb3e47b914f872533bae227
ToppCell	LPS_IL1RA_TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	EPOR RANBP10 GTSE1 SPECC1 DYRK3	2.68e-05	200	78	5	f100edfd2b3b742458cbbf34de9c403c4d272d3c
ToppCell	TCGA-Bladder\|World / Sample_Type by Project: Shred V9	MYCL ARHGAP23 CARD11 AGAP11	1.13e-04	142	78	4	58d1fdc5ec4e5bf307b7a502c081a8a84d7560cd
ToppCell	PBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_2\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF385D BPI FHOD3 INKA2	1.16e-04	143	78	4	9836a040a2ebcf6f05431e658a7b8fd566621452
ToppCell	PBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-Neu_2\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZNF385D BPI FHOD3 INKA2	1.16e-04	143	78	4	4622c221b5d2d4cd4f37e4f81662e073924e1507
ToppCell	Bronchus_Control_(B.)-Immune-TX-TRAM-3\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	ARHGAP24 AFF3 CARD11 C1orf167	1.29e-04	147	78	4	50a855aa7f214c3be8ac46a22adf9bc9dd0285db
ToppCell	Enthrocyte\|World / shred on cell class and cell subclass (v4)	RANBP10 STAC2 SPECC1 DYRK3	1.51e-04	153	78	4	654265f3c14344071b2af7ca05cbdbb17ce2c5d3
ToppCell	Enthrocyte\|World / shred on cell class and cell subclass (v4)	RANBP10 STAC2 SPECC1 DYRK3	1.51e-04	153	78	4	105b91f5277d145f7717307d7eb9b7d8e8e23576
ToppCell	Leuk-UTI-Lymphocyte-T_NK-CD4_CTL\|Leuk-UTI / Disease, Lineage and Cell Type	TLE2 GATA6 RFPL3S PRDM1	1.55e-04	154	78	4	170a421fd69dba2929568c72e983ae9cfaf2aabc
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Lypd1_Gpr88\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	C2CD4B COBL FHOD3 INKA2	1.67e-04	157	78	4	5aee90ad7aaa65fdabc23597451da5e48db8f4e6
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MYCL IQCJ-SCHIP1 AGAP11 NOPCHAP1	1.71e-04	158	78	4	216b3f482daa2d0d7fcaf5a8559e3ccbdb8e110d
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MYCL IQCJ-SCHIP1 AGAP11 NOPCHAP1	1.71e-04	158	78	4	9712bb8b1bacb8a38c99a22bc2babec5d5160e2a
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Pld5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	C2CD4B COBL FHOD3 INKA2	1.75e-04	159	78	4	a082e770fa757c4a1d3ed13d53f83297e36faf05
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Cbln4_Fezf2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	C2CD4B COBL FHOD3 INKA2	1.79e-04	160	78	4	d8241404d775f9a709abdf17988f36293fcf4c58
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D231\|Adult / Lineage, Cell type, age group and donor	ZNF385D CACNA1C AKR1D1 MICAL3	1.79e-04	160	78	4	d783d29150033e9181c0e30870070268fed3fd85
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TLE2 AFF3 GATA6 SPECC1	1.88e-04	162	78	4	5f009b231f21861afee9cc0c569082e1135f929c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TLE2 AFF3 GATA6 SPECC1	1.88e-04	162	78	4	b936f8040dcd4db621ccded19237af8df7d0ed6e
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma\|TCGA-Endometrium / Sample_Type by Project: Shred V9	ARHGAP23 MYT1 CARD11 IQCJ-SCHIP1	1.97e-04	164	78	4	08c725548e751f815b4df778607270498204b353
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARHGAP42 ZNF385D CACNA1C STAC2	1.97e-04	164	78	4	e3983f655cdba308fb192182829f17bef99ce0ba
ToppCell	facs-Spleen-nan-18m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR SCHIP1 ARHGAP23 CENPE	2.06e-04	166	78	4	8d535fab019356894b4dad3fbdbc4d2ad3e16082
ToppCell	facs-Spleen-nan-18m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR SCHIP1 ARHGAP23 CENPE	2.06e-04	166	78	4	f56b1c0d6cb5353a16a2598bda905287f16d2c39
ToppCell	facs-Spleen-nan-18m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR SCHIP1 ARHGAP23 CENPE	2.06e-04	166	78	4	a5074c96c6561273029aceb93402a7e038140f50
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	C2CD4B COBL FHOD3 INKA2	2.11e-04	167	78	4	f1ce6e64ebede1f3ef36fe982f46919fd1f814dd
ToppCell	facs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR RANBP10 FHOD3 MICAL3	2.16e-04	168	78	4	17fb9426eeea407b26fb895b8397faca95b7552d
ToppCell	facs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR RANBP10 FHOD3 MICAL3	2.16e-04	168	78	4	a61b39884851384cffd430079040546d125b2b40
ToppCell	mild_COVID-19-HSPC\|mild_COVID-19 / disease group, cell group and cell class (v2)	ZNF385D CACNA1C C2CD4B C1orf167	2.16e-04	168	78	4	90b33962adb77d8326dee403712118398b4d1315
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_E\|368C / Donor, Lineage, Cell class and subclass (all cells)	CENPE AFF3 MICAL3 MBD5	2.21e-04	169	78	4	0d96c0b4fd26fbc0bf44ff7bed2936eebcc55b74
ToppCell	343B-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ARHGAP24 ARHGAP23 KDM5A CARD11	2.21e-04	169	78	4	632aa3ab39ec87bafcefec6cddf71129a054d3b0
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP24 AFF3 CARD11 PRDM1	2.26e-04	170	78	4	a965e3ee6818790a4a6916824fde64333d9b11b7
ToppCell	mild_COVID-19-HSPC\|World / disease group, cell group and cell class (v2)	ZNF385D CACNA1C C2CD4B C1orf167	2.26e-04	170	78	4	85c476e0bc496445e868a88849960598d97bdea2
ToppCell	Children_(3_yrs)-Immune-B_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARHGAP24 AFF3 CARD11 MICAL3	2.26e-04	170	78	4	e421f9eedf74baffda1d03707a710ece4b777f29
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Penk_Col27a1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	EPOR SCHIP1 COBL INKA2	2.31e-04	171	78	4	d07e2c5f7d7f12c68860d4161d76372de174f1d8
ToppCell	Children_(3_yrs)-Immune-dendritic_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MYCL CARD11 NOPCHAP1 SPECC1	2.31e-04	171	78	4	6a5ac0f56bd7b4543be103100fb735ca6bc5b8bf
ToppCell	Adult-Mesenchymal-pericyte_cell-D231\|Adult / Lineage, Cell type, age group and donor	ARHGAP42 CACNA1C AGTR1 BEND2	2.36e-04	172	78	4	858cee96c1c06160863b4adcd7023c0d678bd50f
ToppCell	10x5'-Lung-Lymphocytic_B-Memory_B_cells\|Lung / Manually curated celltypes from each tissue	ARHGAP24 MYT1 AFF3 MICAL3	2.36e-04	172	78	4	2cb2dc7cfd6db5a98a393b1a84c23abf3d692a53
ToppCell	droplet-Lung-nan-3m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCL LRRC46 CARD6 CARD11	2.41e-04	173	78	4	1b9b4e165121b08ef15a93fca6bea875cae69f19
ToppCell	droplet-Lung-nan-3m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCL LRRC46 CARD6 CARD11	2.41e-04	173	78	4	c25f24d7b672c9686d31ebc8d263042282f520fd
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors\|lymph-node_spleen / Manually curated celltypes from each tissue	SCHIP1 CENPE GTSE1 IQCJ-SCHIP1	2.47e-04	174	78	4	029394e107bf7ad58056d2216070aa2e964fff12
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP42 EPOR SCHIP1 ARHGAP24	2.52e-04	175	78	4	d2ff8fedca9039cbd45cfd9dec88f4edbe7fe4fc
ToppCell	343B-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	ARHGAP24 ARHGAP23 KDM5A CARD11	2.52e-04	175	78	4	b30589ff9dc18e745afe61f289e6d576c9c6c6b2
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP42 EPOR SCHIP1 ARHGAP24	2.52e-04	175	78	4	a7310950e8d51b3004ea3aee8ce9948fe8655112
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	EPOR SCHIP1 COBL INKA2	2.52e-04	175	78	4	c227fc5d1ccb69b82a96a6354913cafaf27d0eec
ToppCell	droplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYCL CENPE GTSE1 HIRA	2.52e-04	175	78	4	73f25bd54309aed1480ddc44bdab518b17e71f92
ToppCell	droplet-Marrow-nan-24m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR RANBP10 USP32 SPECC1	2.58e-04	176	78	4	fc51e4dcad5456c229d76fdcb9a80c4c79eacf3f
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-HSC-MPP\|lymph-node_spleen / Manually curated celltypes from each tissue	ZNF385D SCHIP1 CENPE IQCJ-SCHIP1	2.58e-04	176	78	4	de67ed15a50d2515ba6d152c1011a3367f77aedd
ToppCell	Control-B_cells-B_cells\|Control / group, cell type (main and fine annotations)	ARHGAP24 AFF3 CARD11 MICAL3	2.58e-04	176	78	4	d2c353783bd78dc24f28e00d917b88d8294fb5df
ToppCell	COVID-19-lung-B_cells\|lung / Disease (COVID-19 only), tissue and cell type	ARHGAP24 AFF3 CARD11 MICAL3	2.63e-04	177	78	4	f54691e5558091c1734ab15153a10bff15ed171e
ToppCell	facs-Skin-Anagen-24m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC46 CENPE ZNF804B DYRK3	2.63e-04	177	78	4	8a0f0fbb06cdacb99a3fdba0da3e0494b891db4f
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARHGAP42 ZNF385D CACNA1C MEIOSIN	2.63e-04	177	78	4	b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCell	COPD-Epithelial-Aberrant_Basaloid\|World / Disease state, Lineage and Cell class	ARHGAP42 TLE2 TMPRSS2 COBL	2.63e-04	177	78	4	22b7cda748cf5e665be54ca5bae89f0c130d5e7f
ToppCell	facs-Skin-Anagen-24m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC46 CENPE ZNF804B DYRK3	2.63e-04	177	78	4	e9d7682517fb30fd2ad535d59779d718a7024c13
ToppCell	Control-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP24 GATA6 TMPRSS2 COBL	2.63e-04	177	78	4	9af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF385D LAMA1 COBL FHOD3	2.69e-04	178	78	4	dfed0fbf7a73b8a9e00178ec58dc4592b271c344
ToppCell	facs-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGAP42 EPOR SCHIP1 ARHGAP24	2.69e-04	178	78	4	8bae5db100f4563aa1fc7f881e7f8c59d669e37a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AGTR1 AFF3 GATA6 SPECC1	2.69e-04	178	78	4	d4ecb84e9b1f4ec49c519321156aa10f9bd34cce
ToppCell	facs-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGAP42 EPOR SCHIP1 ARHGAP24	2.69e-04	178	78	4	bc0336692b84bd0fa49747ed5a031b8ed8afa0fd
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TLL2 AGTR1 FHOD3 MICAL3	2.69e-04	178	78	4	a0ab20c588e7d43d0320d4779d9ab95c1c86e297
ToppCell	droplet-Spleen-nan-24m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR CENPE SPECC1 DYRK3	2.75e-04	179	78	4	f3f9c7e575bc4d9d3bce649b90254182e8f6aaec
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF385D LAMA1 COBL FHOD3	2.75e-04	179	78	4	d0fa700648db8ce76a8aa689879a25048299fa40
ToppCell	droplet-Spleen-nan-24m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR CENPE SPECC1 DYRK3	2.75e-04	179	78	4	01e0b49e7f03ac9c3e6c34708ead300d27236b8b
ToppCell	Children_(3_yrs)-Immune-B_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARHGAP24 AFF3 CARD11 MICAL3	2.75e-04	179	78	4	31411780f1a44bf2d102f288416e97eacec4b6b6
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF385D LAMA1 COBL FHOD3	2.75e-04	179	78	4	2e49b215b71438400aebb483f2c2c08d5e956961
ToppCell	Children_(3_yrs)-Immune-B_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARHGAP24 AFF3 CARD11 MICAL3	2.81e-04	180	78	4	40a12eb852373ae3d7c8d9bca376b0ae99f724b3
ToppCell	18-Airway-RBC\|Airway / Age, Tissue, Lineage and Cell class	EPOR CENPE SPECC1 DYRK3	2.81e-04	180	78	4	35bf5f35cf346a5b27f5e819b77db34130d70db1
ToppCell	18-Airway-RBC-RBC\|Airway / Age, Tissue, Lineage and Cell class	EPOR CENPE SPECC1 DYRK3	2.81e-04	180	78	4	3b4b220a3c150426ae55239baff756f1a7f1e1d7
ToppCell	facs-Lung-18m-Mesenchymal-myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGAP42 EPOR SCHIP1 ARHGAP24	2.87e-04	181	78	4	dff264815a3569f5666d0bbc3867c0496cd78774
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGAP42 ZNF385D DNAI1 PRDM1	2.87e-04	181	78	4	bd7e9437839bca543ca5945df43d6525e6a312a8
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SCHIP1 COBL FHOD3 INKA2	2.87e-04	181	78	4	58f76bb9ea1518c2b629a0256a3f6595a9278152
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-secretory_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCL ARHGAP24 CENPE GTSE1	2.87e-04	181	78	4	b203b616584cdbd0bbb0e382b2916d0bd49d3526
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCL ARHGAP24 CENPE GTSE1	2.87e-04	181	78	4	c748c16fd20d1949d33ff6290dc9d9016c4dc86c
ToppCell	RA-07._Pericyte\|World / Chamber and Cluster_Paper	ARHGAP42 CACNA1C TLE2 SPECC1	2.93e-04	182	78	4	2075efeae633550fb2eb026d0dfd741c8252482e
ToppCell	COVID-19-Heart-EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ARHGAP42 ZNF385D CACNA1C SPECC1	2.93e-04	182	78	4	e67f3234165199085c793915ebb1f9bbd845e933
Drug	2-propylpentanoic acid; Down 200; 500uM; MCF7; HT_HG-U133A	MICALL1 ATXN2 KDM5A SQSTM1 NFX1 ZC3H7B CIC	4.80e-06	195	78	7	1665_DN
Drug	Dorzolamide hydrochloride [130693-82-2]; Down 200; 11uM; PC3; HT_HG-U133A	MYCL SZT2 ATXN2 TNRC6B COBL ZC3H7B HIRA	5.13e-06	197	78	7	5785_DN
Drug	Bumetanide [28395-03-1]; Down 200; 11uM; MCF7; HT_HG-U133A	MICALL1 EPOR FURIN NFX1 TNRC6B ZC3H7B HIRA	5.13e-06	197	78	7	7440_DN
Drug	Cisapride [81098-60-4]; Down 200; 8.6uM; MCF7; HT_HG-U133A	MYCL EPOR KDM5A TLE2 MICAL3 ZC3H7B CIC	5.30e-06	198	78	7	3305_DN
Disease	Antihypertensive use measurement	ARHGAP42 CACNA1C CYB5B ARHGAP24 ATXN2 FURIN YES1	5.61e-06	265	76	7	EFO_0009927
Disease	cortical thickness	MICALL1 ZNF438 ATXN2 FURIN LAMA1 TNRC6B AFF1 MICAL3 TMEM131 IQCJ-SCHIP1 QSER1 SPECC1	2.61e-05	1113	76	12	EFO_0004840
Disease	hypothyroidism	ATXN2 MYT1 ZNF804B CARD11 TMEM131 ZC3H7B	9.37e-05	284	76	6	EFO_0004705
Disease	cryptic phenotype measurement	ARHGAP42 ATXN2 CHRNA4	2.45e-04	47	76	3	EFO_0021487
Disease	diastolic blood pressure, alcohol drinking	ARHGAP42 ATXN2 FURIN C1orf167	2.50e-04	118	76	4	EFO_0004329, EFO_0006336
Disease	cerebral palsy (implicated_via_orthology)	AGAP11 AGAP9	2.91e-04	10	76	2	DOID:1969 (implicated_via_orthology)
Disease	systolic blood pressure, alcohol drinking	ARHGAP42 ATXN2 FURIN C1orf167	3.40e-04	128	76	4	EFO_0004329, EFO_0006335
Disease	diastolic blood pressure, alcohol consumption measurement	ARHGAP42 ATXN2 FURIN	3.71e-04	54	76	3	EFO_0006336, EFO_0007878
Disease	neuroimaging measurement	ZNF438 STAC2 SZT2 ATXN2 FURIN AFF3 TNRC6B AFF1 IQCJ-SCHIP1 QSER1	4.08e-04	1069	76	10	EFO_0004346
Disease	tumor necrosis factor measurement	BPI ATXN2	6.73e-04	15	76	2	EFO_0010834
Disease	pulse pressure measurement	ARHGAP42 ZNF438 ARHGAP24 KDM5A MYT1 FURIN TNRC6B FHOD3 IQCJ-SCHIP1 MBD5 YES1	8.46e-04	1392	76	11	EFO_0005763
Disease	diet measurement, HOMA-B	PCNX2 CYB5B	1.09e-03	19	76	2	EFO_0004469, EFO_0008111
Disease	hypertension	ARHGAP42 SZT2 ATXN2 FURIN YES1	1.19e-03	307	76	5	EFO_0000537
Disease	Attention Deficit Disorder	CIC CHRNA4	1.46e-03	22	76	2	C0041671
Disease	Minimal Brain Dysfunction	CIC CHRNA4	1.46e-03	22	76	2	C1321905
Disease	cholelithiasis	ZNF438 CYB5B TNRC6B	1.54e-03	88	76	3	EFO_0004799
Disease	diastolic blood pressure, systolic blood pressure	CEP350 CACNA1C CYB5B RANBP10 ATXN2 TNRC6B AFF1	1.70e-03	670	76	7	EFO_0006335, EFO_0006336
Disease	parental longevity	CEP350 ARHGAP42 ATXN2 FURIN AKR1D1 CHRNA4	1.74e-03	494	76	6	EFO_0007796
Disease	Attention deficit hyperactivity disorder	CIC CHRNA4	1.74e-03	24	76	2	C1263846
Disease	mean arterial pressure	ARHGAP42 ARHGAP24 SZT2 ATXN2 FURIN YES1	1.83e-03	499	76	6	EFO_0006340
Disease	mean arterial pressure, alcohol drinking	ARHGAP42 ATXN2 FURIN	2.10e-03	98	76	3	EFO_0004329, EFO_0006340
Disease	glaucoma (biomarker_via_orthology)	EPOR SQSTM1	2.37e-03	28	76	2	DOID:1686 (biomarker_via_orthology)
Disease	Thyroid preparation use measurement	ATXN2 AFF1 TMEM131 ZC3H7B	2.41e-03	217	76	4	EFO_0009933
Disease	Amyotrophic Lateral Sclerosis With Dementia	ATXN2 SQSTM1	2.54e-03	29	76	2	C0393554
Disease	longevity, healthspan, parental longevity	ATXN2 FURIN	2.54e-03	29	76	2	EFO_0004300, EFO_0007796, EFO_0009762

Protein segments in the cluster

Peptide	Gene	Start	Entry
KVEKSPTTATGNSSC	ZNF385D	176	Q9H6B1
PNCRTSVPSSKGSSS	AFF3	401	P51826
CTCKKEPSSVSPSAT	CHRNA4	531	P43681
ALGPDATSSCTKTPS	C1orf167	826	Q5SNV9
CAPISSSKSNGLSKD	AGAP11	191	Q8TF27
CFSPGISSTTSPKLN	AGAP9	421	Q5VTM2
YSEPKSTPKGACATS	AKR1D1	26	P51857
PSDNVSSSTKKPAPC	AGTR1	341	P30556
TSNPFKSSKCSTAGS	SPECC1	346	Q5M775
KSSKCSTAGSSPNSV	SPECC1	351	Q5M775
PHSQPSFCSSAKSGK	DNAI1	416	Q9UI46
SPSCSNGVASTKSKQ	RANBP10	386	Q6VN20
SPSKSPAKLNQSGTS	RANBP2	2276	P49792
SGYPPSTTKIKSCST	QSER1	271	Q2KHR3
TSFCPDTPSEKTAKG	KPNA7	51	A9QM74
DDKSCPSTPSSGATV	MICAL3	1756	Q7RTP6
CSPSSQPSLGSSTKF	INKA2	91	Q9NTI7
NCTSGSSKPNSPSIS	ATXN2	851	Q99700
SGQDSSSSSVCIPPK	BEND2	461	Q8NDZ0
KLCSSAAGSSAPKPA	C2CD4B	6	A6NLJ0
TSTGPACTQPAKTTA	PCNX2	646	A6NKB5
SFQSSPCNKSPKSHG	NFX1	86	Q12986
SPGSSSPQLQVKSSC	MICALL1	616	Q8N3F8
SSPQASSPTKKPCSL	LRRC46	266	Q96FV0
STPSSSPSSQKSCLQ	MEIOSIN	156	C9JSJ3
SSACTSPAVGKAKSS	GTSE1	321	Q9NYZ3
SKSCSQGSSTPRKQP	KDM5A	1406	P29375
VKATGNSTPCTSSLP	NFYC	336	Q13952
SPTALSGSKTNSPKN	ARHGAP24	391	Q8N264
CSKNTSPTTQPTASG	GATA6	526	Q92908
HSVPSQPKSSQTKSC	CARD6	961	Q9BX69
QSQPSQTKPSPCKST	CARD6	976	Q9BX69
GKKCAPESEPSNSTE	CACNA1C	1476	Q13936
DQSKPNCTKDSTSGS	DNAJB14	71	Q8TBM8
PPESSGCKTLTSSQA	FURIN	581	P09958
GSNPTSGKPTITCSS	BPI	151	P17213
KRSNSKGCLTTPNSP	COBL	256	O75128
PESGSKDPSKNDTCK	CYB5B	106	O43169
KSTLSAPTSPCSQSA	FHOD3	371	Q2V2M9
SSTSPSKHSLPKSCT	CEP350	1986	Q5VT06
NGCVPSPSDAKSISS	MBD5	1346	Q9P267
CSSALASKPSPEGAS	EPOR	406	P19235
SSTPNSFGASKPCTE	HIRA	506	P54198
DPPSAKKSIPSSECS	RSC1A1	226	Q92681
PSSCGSLPITNSFTK	CARD11	536	Q9BXL7
TCENSPKSPKVTGTA	CENPE	2601	Q02224
SDSEKCSPTVSQGKS	DYRK3	106	O43781
ISGPECTTPKASTSA	TAF3	426	Q5VWG9
SCPKTKTDGSPKSTS	SZT2	2961	Q5T011
SPSKSPAKLNQSGTS	RGPD4	1301	Q7Z3J3
STTKSASCQPREKSG	ARHGAP42	646	A6NI28
KVTPCSECKSSSSPG	SCHIP1	51	P0DPB3
SSNQKSPTKTSKSPG	LAMA1	2221	P25391
KDKACSPTSGSPTAG	PRDM1	506	O75626
TKVTPCSECKSSSSP	IQCJ-SCHIP1	126	B3KU38
KPKASPSCSSPTRDS	NOPCHAP1	6	Q8N5I9
SISGSKKPTNDSNPS	SPTY2D1	411	Q68D10
SKALGAKGSCETTPS	RITA1	71	Q96K30
KSSSQPSSCCSDPSK	SQSTM1	281	Q13501
TCGQDPPKSASSTKS	AFF1	891	P51825
SSEPNTPKSAKCEGD	CIC	1421	Q96RK0
TGKAVSEPSCTTNTK	C12orf56	211	Q8IXR9
CTQPKSPSGTVCTSK	TMPRSS2	66	O15393
NSQISCTGSSKKPPN	ZNF804B	831	A4D1E1
PKTQACSGSESPSDS	MYCL	151	P12524
GQKPTPCLSSTSKAQ	RFPL3S	56	P0C7P2
PGSDSTTCSSAKSKG	ARHGAP23	1136	Q9P227
CATSKESPPTGDSGK	STAC2	186	Q6ZMT1
SSSSSDPKIKQPNGS	TMEM131	1626	Q92545
CGSKKPDPTVASGSS	TLL2	851	Q9Y6L7
ADSACSSPAPSTGKV	SENP6	356	Q9GZR1
GLSSSPPKKCARSES	UBXN7	266	O94888
ASTPASKSCDSSPPQ	TLE2	296	Q04725
AGQPSKKPSTLLSCS	UHRF1BP1	481	Q6BDS2
CKQDNSSSPKPSSVF	ZNF438	481	Q7Z4V0
PKGSPSSSRKSGTSC	USP6	1171	P35125
RKSGTSCPSSKNSSP	USP32	1381	Q8NFA0
SPPTNKIGSKSSNAS	TNRC6B	1461	Q9UPQ9
PCPSSSAKGTAVNFS	YES1	41	P07947
SKGTKDSPSVCSNLA	ZC3H7B	566	Q9UGR2
SSSCSSSPGVKSPDA	MYT1	686	Q01538