Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF675 ZNF430 ZNF708 ZNF141 ZNF676 ZNF142 ZNF117 ZNF211 ZNF486 ZNF680 ZNF37A ZNF644 ZNF735 ZNF66 ZNF727 ZNF208 ZNF721 ZNF85 ZNF91 ZNF626 ZNF883 PRDM16 TAF1L ZNF791 ZNF287	6.83e-16	1459	50	25	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF675 ZNF430 ZNF708 ZNF141 ZNF676 ZNF142 ZNF117 ZNF211 ZNF486 ZNF680 ZNF37A ZNF644 ZNF735 ZNF66 ZNF727 ZNF208 ZNF721 ZNF85 ZNF91 ZNF626 ZNF883 PRDM16 ZNF791 ZNF287	4.11e-15	1412	50	24	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF675 ZNF430 ZNF708 ZNF141 ZNF676 ZNF117 ZNF211 ZNF486 ZNF680 ZNF37A ZNF644 ZNF735 ZNF66 ZNF727 ZNF208 ZNF721 ZNF85 ZNF91 ZNF626 ZNF883 PRDM16 ZNF287	4.14e-14	1244	50	22	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF675 ZNF430 ZNF708 ZNF141 ZNF676 ZNF117 ZNF211 ZNF486 ZNF680 ZNF37A ZNF644 ZNF735 ZNF66 ZNF727 ZNF208 ZNF721 ZNF85 ZNF91 ZNF626 ZNF883 PRDM16 ZNF287	6.42e-14	1271	50	22	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF727 ZNF208 ZNF721 ZNF85 ZNF91 PRDM16	1.42e-04	320	50	6	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF727 ZNF208 ZNF721 ZNF85 ZNF91 PRDM16	1.57e-04	326	50	6	GO:0001217
MousePheno	decreased eosinophil cell number	ZNF727 ZNF208 ZNF721 ZNF85 ZNF91	4.14e-07	84	26	5	MP:0005012
MousePheno	decreased granulocyte number	ZNF727 ZNF208 ZNF721 ZNF85 ZNF91	9.16e-05	254	26	5	MP:0000334
MousePheno	abnormal eosinophil cell number	ZNF727 ZNF208 ZNF721 ZNF85 ZNF91	9.34e-05	255	26	5	MP:0002602
MousePheno	abnormal eosinophil morphology	ZNF727 ZNF208 ZNF721 ZNF85 ZNF91	1.02e-04	260	26	5	MP:0005061
Domain	ZINC_FINGER_C2H2_2	ZNF675 ZNF430 ZNF708 ZNF141 ZNF676 ZNF142 ZNF117 ZNF211 ZNF486 ZNF680 ZNF37A ZNF592 ZNF644 ZNF735 SCAPER ZNF727 ZNF208 ZNF721 ZNF85 ZNF91 ZNF626 ZNF883 PRDM16 ZNF791 ZNF287	1.21e-22	775	47	25	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF675 ZNF430 ZNF708 ZNF141 ZNF676 ZNF142 ZNF117 ZNF211 ZNF486 ZNF680 ZNF37A ZNF592 ZNF644 ZNF735 SCAPER ZNF727 ZNF208 ZNF721 ZNF85 ZNF91 ZNF626 ZNF883 PRDM16 ZNF791 ZNF287	1.28e-22	777	47	25	PS00028
Domain	zf-C2H2	ZNF675 ZNF430 ZNF708 ZNF141 ZNF676 ZNF142 ZNF117 ZNF211 ZNF486 ZNF680 ZNF37A ZNF592 ZNF644 ZNF735 ZNF727 ZNF208 ZNF721 ZNF85 ZNF91 ZNF626 ZNF883 PRDM16 ZNF791 ZNF287	2.27e-22	693	47	24	PF00096
Domain	Znf_C2H2-like	ZNF675 ZNF430 ZNF708 ZNF141 ZNF676 ZNF142 ZNF117 ZNF211 ZNF486 ZNF680 ZNF37A ZNF592 ZNF644 ZNF735 SCAPER ZNF727 ZNF208 ZNF721 ZNF85 ZNF91 ZNF626 ZNF883 PRDM16 ZNF791 ZNF287	2.32e-22	796	47	25	IPR015880
Domain	Znf_C2H2	ZNF675 ZNF430 ZNF708 ZNF141 ZNF676 ZNF142 ZNF117 ZNF211 ZNF486 ZNF680 ZNF37A ZNF592 ZNF644 ZNF735 SCAPER ZNF727 ZNF208 ZNF721 ZNF85 ZNF91 ZNF626 ZNF883 PRDM16 ZNF791 ZNF287	3.05e-22	805	47	25	IPR007087
Domain	ZnF_C2H2	ZNF675 ZNF430 ZNF708 ZNF141 ZNF676 ZNF142 ZNF117 ZNF211 ZNF486 ZNF680 ZNF37A ZNF592 ZNF644 ZNF735 SCAPER ZNF727 ZNF208 ZNF721 ZNF85 ZNF91 ZNF626 ZNF883 PRDM16 ZNF791 ZNF287	3.34e-22	808	47	25	SM00355
Domain	Znf_C2H2/integrase_DNA-bd	ZNF675 ZNF430 ZNF708 ZNF141 ZNF676 ZNF142 ZNF117 ZNF211 ZNF486 ZNF680 ZNF37A ZNF644 ZNF735 ZNF727 ZNF208 ZNF721 ZNF85 ZNF91 ZNF626 ZNF883 PRDM16 ZNF791 ZNF287	6.29e-21	694	47	23	IPR013087
Domain	-	ZNF675 ZNF430 ZNF708 ZNF141 ZNF676 ZNF142 ZNF117 ZNF211 ZNF486 ZNF680 ZNF37A ZNF644 ZNF735 ZNF727 ZNF208 ZNF721 ZNF85 ZNF91 ZNF626 ZNF883 PRDM16 ZNF791	9.72e-20	679	47	22	3.30.160.60
Domain	zf-C2H2_6	ZNF675 ZNF141 ZNF676 ZNF117 ZNF211 ZNF486 ZNF680 ZNF735 ZNF727 ZNF208 ZNF721 ZNF85 ZNF91 ZNF626 ZNF883 PRDM16 ZNF791	7.72e-19	314	47	17	PF13912
Domain	KRAB	ZNF675 ZNF430 ZNF708 ZNF141 ZNF676 ZNF211 ZNF486 ZNF680 ZNF37A ZNF735 ZNF727 ZNF208 ZNF85 ZNF91 ZNF626 ZNF791 ZNF287	7.09e-18	358	47	17	PS50805
Domain	KRAB	ZNF675 ZNF430 ZNF708 ZNF141 ZNF676 ZNF211 ZNF486 ZNF680 ZNF37A ZNF735 ZNF727 ZNF208 ZNF85 ZNF91 ZNF626 ZNF791 ZNF287	1.18e-17	369	47	17	SM00349
Domain	KRAB	ZNF675 ZNF430 ZNF708 ZNF141 ZNF676 ZNF211 ZNF486 ZNF680 ZNF37A ZNF735 ZNF727 ZNF208 ZNF85 ZNF91 ZNF626 ZNF791 ZNF287	1.23e-17	370	47	17	IPR001909
Domain	KRAB	ZNF675 ZNF430 ZNF708 ZNF141 ZNF211 ZNF486 ZNF680 ZNF37A ZNF735 ZNF727 ZNF208 ZNF85 ZNF91 ZNF626 ZNF791 ZNF287	2.08e-16	358	47	16	PF01352
Domain	zf-C2H2_11	ZNF592 ZNF721	2.21e-04	9	47	2	PF16622
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF675 ZNF430 ZNF708 ZNF141 ZNF676 ZNF211 ZNF486 ABL1 ZNF680 ZNF37A ZNF735 ZNF727 ZNF208 ZNF721 ZNF626 TAF1L ZNF791 ZNF287	1.08e-09	1387	36	18	M734
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF430 ZNF708 ZNF211 ZNF486 ZNF680 ZNF644 ZNF208 ZNF721 ZNF91 ZNF626 ZNF791	1.75e-15	181	50	11	37372979
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF727 ZNF208 ZNF721 ZNF85 ZNF91 ZNF626	3.00e-12	29	50	6	14563677
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF727 ZNF208 ZNF721 ZNF85 ZNF91 ZNF287	8.63e-11	49	50	6	9630514
Pubmed	The human genome contains hundreds of genes coding for finger proteins of the Krüppel type.	ZNF117 ZNF85 ZNF91	5.57e-08	6	50	3	2505992
Pubmed	The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.	ZNF117 ZNF85 ZNF91	1.56e-07	8	50	3	2023909
Pubmed	Functional analysis of the SRY-KRAB interaction in mouse sex determination.	ZNF208 ZNF721 ZNF91	3.33e-07	10	50	3	18588511
Pubmed	Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.	ZNF208 ZNF721 ZNF91	4.58e-07	11	50	3	15469996
Pubmed	Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.	ZNF208 ZNF721 ZNF91	7.92e-07	13	50	3	19850934
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF208 ZNF721 ZNF91	1.26e-06	15	50	3	15885501
Pubmed	Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.	ZNF208 ZNF85 ZNF91	1.55e-06	16	50	3	8467795
Pubmed	Cloning of a DNA binding protein that is a tyrosine kinase substrate and recognizes an upstream initiator-like sequence in the promoter of the preprodynorphin gene.	ABL1 HUWE1	2.03e-06	2	50	2	7968380
Pubmed	Evolution of KRAB-containing zinc finger proteins and their roles in species evolution.	ZNF735 ZNF727	1.21e-05	4	50	2	27867147
Pubmed	Zinc fingers function cooperatively with KRAB domain for nuclear localization of KRAB-containing zinc finger proteins.	ZNF735 ZNF727	1.21e-05	4	50	2	24647005
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF592 ZNF644 SCAPER ZNF208 ZNF721 ZNF91 ZNF626 PRDM16	1.86e-05	808	50	8	20412781
Pubmed	The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins.	ABL1 SOS2	2.02e-05	5	50	2	9067577
Pubmed	Cys2His2 zinc finger protein family: classification, functions, and major members.	ZNF735 ZNF727	3.03e-05	6	50	2	22803940
Pubmed	A novel proteomic screen for peptide-protein interactions.	ABL1 SOS2	7.25e-05	9	50	2	14679214
Pubmed	Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering.	ZNF708 ZNF37A	1.82e-04	14	50	2	2014798
Pubmed	CRL7SMU1 E3 ligase complex-driven H2B ubiquitylation functions in sister chromatid cohesion by regulating SMC1 expression.	SMU1 HUWE1	3.05e-04	18	50	2	29507117
Pubmed	ATRX proximal protein associations boast roles beyond histone deposition.	ZNF592 ZNF644 KIF18B	3.11e-04	91	50	3	34780483
Pubmed	Multiple genes encoding zinc finger domains are expressed in human T cells.	ZNF708 ZNF37A	9.17e-04	31	50	2	2288909
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF592 ATAD5 SCAPER FASTKD5 REV3L KIF18B PRDM16	1.03e-03	1116	50	7	31753913
Pubmed	SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.	ZNF644 REV3L KIF18B	1.33e-03	150	50	3	30154076
Interaction	TRIM28 interactions	ZNF675 ZNF430 ZNF708 ZNF211 ZNF486 ZNF680 ZNF37A ZNF644 SMU1 ZNF208 ZNF721 ZNF85 HUWE1 ZNF91 ZNF626 ZNF791 ZNF287	2.14e-08	1474	48	17	int:TRIM28
Cytoband	19p12	ZNF675 ZNF430 ZNF708 ZNF676 ZNF486 ZNF66 ZNF208 ZNF85 ZNF91 ZNF626	4.82e-18	90	50	10	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF675 ZNF430 ZNF708 ZNF676 ZNF486 ZNF66 ZNF208 ZNF85 ZNF91 ZNF626	1.13e-16	122	50	10	chr19p12
Cytoband	7q11.21	ZNF117 ZNF680 ZNF735 ZNF727	2.15e-06	83	50	4	7q11.21
Cytoband	Ensembl 112 genes in cytogenetic band chr7q11	ZNF117 ZNF680 ZNF735 ZNF727	2.21e-04	271	50	4	chr7q11
Cytoband	Ensembl 112 genes in cytogenetic band chr11q11	OR4C11 OR4C6	8.83e-04	40	50	2	chr11q11
Cytoband	11q11	OR4C11 OR4C6	1.22e-03	47	50	2	11q11
Cytoband	4p16.3	ZNF141 ZNF721	3.92e-03	85	50	2	4p16.3
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF675 ZNF430 ZNF708 ZNF141 ZNF676 ZNF142 ZNF117 ZNF211 ZNF486 ZNF680 ZNF37A ZNF592 ZNF735 SCAPER ZNF727 ZNF208 ZNF721 ZNF85 ZNF91 ZNF626 ZNF883 PRDM16 ZNF791 ZNF287	2.93e-23	718	42	24	28
Coexpression	COATES_MACROPHAGE_M1_VS_M2_UP	ZNF727 ZNF208 ZNF721 ZNF85 ZNF91	1.21e-06	102	48	5	MM749
Coexpression	TERAO_AOX4_TARGETS_SKIN_DN	ZNF208 ZNF721 ZNF91	1.83e-05	28	48	3	MM925
Coexpression	DURAND_STROMA_NS_UP	ZNF727 ZNF208 ZNF721 ZNF85 ZNF91	2.79e-05	194	48	5	MM962
Coexpression	GSE22601_DOUBLE_NEGATIVE_VS_IMMATURE_CD4_SP_THYMOCYTE_UP	ZNF592 SMU1 ZNF85 ZNF91 TAF1L	3.23e-05	200	48	5	M6234
Disease	bilirubin measurement	ABL1 SLCO1B3 REV3L L3MBTL4 SOS2	5.50e-04	442	45	5	EFO_0004570
Disease	carnosine measurement	ZNF675 OXR1	6.14e-04	24	45	2	EFO_0010470
Disease	response to radiation, hearing loss, response to antineoplastic agent	ZNF66 ZNF85	2.26e-03	46	45	2	EFO_0004238, GO_0009314, GO_0097327
Disease	chemokine (C-C motif) ligand 27 measurement	SLCO1B3 TAF1L	5.14e-03	70	45	2	EFO_0008082

Protein segments in the cluster

Peptide	Gene	Start	Entry
KTTAGKKCSALVSHC	ATAD5	1631	Q96QE3
KSSCSKKLSKSSHLE	CXorf66	166	Q5JRM2
KQKFGLTTSSCKSHT	BTBD16	471	Q32M84
KKGRCKAFSTCSSHL	OR8D4	231	Q8NGM9
MGRKCSKAKASSSSH	MAGEB3	331	O15480
KSSGKALFNLSCSHL	FRMD7	21	Q6ZUT3
SKSKSLCSLNFNGKH	L3MBTL4	436	Q8NA19
HSAKGKKKALSACTS	OR4C11	226	Q6IEV9
KGKKSSKSCGSSSHE	HUWE1	3251	Q7Z6Z7
ACKKKRVASSSVSHG	KIF18B	781	Q86Y91
SHSCKTFGNRTLSKK	OXR1	846	Q8N573
HSAKKVKNICSTFSS	FASTKD5	51	Q7L8L6
CKSKKGLSSSSSCYL	ABL1	11	P00519
CKITSSTTGDKHFDK	SCAPER	71	Q9BY12
CSLKSYSSKGRHKAL	OR4C6	221	Q8NH72
SKSFFSSCGSLHKLS	SOS2	1126	Q07890
GGKKKHSCSTKTQSS	SOCS5	121	O75159
FHSGTAAKSITKKCE	GIMAP4	56	Q9NUV9
SMTSLKSSATGHCLK	TAF1L	1171	Q8IZX4
CGKTFATSSGLKQHK	PRDM16	371	Q9HAZ2
KHFCSITSLFKIGSS	SHOC1	1091	Q5VXU9
TRHFKSKTDSNSKKC	ANKDD1B	511	A6NHY2
CGKSFSEKSTLTKHL	ZNF37A	416	P17032
CGKSFTCSSNLIKHK	ZNF727	401	A8MUV8
ECGKAFSKFSILTKH	ZNF676	201	Q8N7Q3
GKAFNCSSTLKTHKI	ZNF735	331	P0CB33
QCGKAFSVSTSLKKH	ZNF791	556	Q3KP31
KCLECGKTFSHSSSL	ZNF287	481	Q9HBT7
KLSGCFSSFLESKKS	REV3L	1291	O60673
HSKGVTCLSFSKDSS	SMU1	306	Q2TAY7
STKRHKSLFQCAKCS	ZNF592	1116	Q92610
CGKVITSSSSFAKHK	ZNF721	466	Q8TF20
LAGCKSSSGIKKHTV	SLCO1B3	486	Q9NPD5
CSKSFSCKSNLIKHL	ZNF211	486	Q13398
FNKKLSSSSSALLHK	PLCH1	1021	Q4KWH8
CGKAFNRSTTLTKHK	ZNF141	316	Q15928
CGKAFKHSSALTTHK	ZNF675	401	Q8TD23
KCGKAFMSSSTLSKH	ZNF626	261	Q68DY1
CPFTTSAKSVLKKHT	ZNF644	591	Q9H582
CGKAFSVFSTLTKHK	ZNF708	341	P17019
CGKAFKQSSTLTTHK	ZNF430	266	Q9H8G1
CGKAFKQFSTLTTHK	ZNF91	551	Q05481
CGKAFRKSSTLTEHK	ZNF91	971	Q05481
CGKAFSKFSILTKHK	ZNF208	346	O43345
CGKSFSTFSVLTKHK	ZNF208	726	O43345
SSKLSTCKKIHTGEK	ZNF117	401	Q03924
CGKAFKCSSILTTHK	ZNF66	486	Q6ZN08
KECGKAFKHSSTLTK	ZNF85	401	Q03923
CGKSFSLSSALTKHK	ZNF883	326	P0CG24
CQKFFTSKSKLKTHL	ZNF142	196	P52746
KCGKAFISSSILSKH	ZNF486	326	Q96H40
CGKAFSLFSILSKHK	ZNF680	271	Q8NEM1