Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylinositol phosphate 4-phosphatase activity	INPP5F INPP4A	1.18e-04	10	33	2	GO:0034596
Domain	KRAB	ZNF799 ZNF443 ZNF426 ZNF563	2.77e-03	358	31	4	PS50805
Domain	KRAB	ZNF799 ZNF443 ZNF426 ZNF563	2.77e-03	358	31	4	PF01352
Domain	KRAB	ZNF799 ZNF443 ZNF426 ZNF563	3.09e-03	369	31	4	SM00349
Domain	KRAB	ZNF799 ZNF443 ZNF426 ZNF563	3.12e-03	370	31	4	IPR001909
Domain	Sushi	CSMD1 APOH	3.36e-03	52	31	2	PF00084
Domain	CCP	CSMD1 APOH	3.62e-03	54	31	2	SM00032
Domain	SUSHI	CSMD1 APOH	3.88e-03	56	31	2	PS50923
Domain	Sushi_SCR_CCP_dom	CSMD1 APOH	4.02e-03	57	31	2	IPR000436
Domain	Znf_C2H2-like	ZNF799 ZMAT4 ZNF443 ZNF426 ZNF563	9.39e-03	796	31	5	IPR015880
Domain	Znf_C2H2	ZNF799 ZMAT4 ZNF443 ZNF426 ZNF563	9.83e-03	805	31	5	IPR007087
Domain	ZnF_C2H2	ZNF799 ZMAT4 ZNF443 ZNF426 ZNF563	9.98e-03	808	31	5	SM00355
Domain	Galactose-bd-like	LAMB2 EPHA7	1.06e-02	94	31	2	IPR008979
Pubmed	Mutant Cockayne syndrome group B protein inhibits repair of DNA topoisomerase I-DNA covalent complex.	ERCC6 PGBD3	9.28e-07	2	34	2	21143350
Pubmed	What role (if any) does the highly conserved CSB-PGBD3 fusion protein play in Cockayne syndrome?	ERCC6 PGBD3	9.28e-07	2	34	2	23369858
Pubmed	The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.	ERCC6 PGBD3	9.28e-07	2	34	2	22483866
Pubmed	An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome.	ERCC6 PGBD3	9.28e-07	2	34	2	18369450
Pubmed	Tethering of the conserved piggyBac transposase fusion protein CSB-PGBD3 to chromosomal AP-1 proteins regulates expression of nearby genes in humans.	ERCC6 PGBD3	2.78e-06	3	34	2	23028371
Pubmed	Both NF-κB and c-Jun/AP-1 involved in anti-β2GPI/β2GPI-induced tissue factor expression in monocytes.	RELA APOH	2.78e-06	3	34	2	23467542
Pubmed	Segmental and restricted localization pattern of Fras1 in the developing meningeal basement membrane in mouse.	LAMB2 FREM3	5.56e-06	4	34	2	24101214
Pubmed	Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.	INPP5F INPP4A	9.26e-06	5	34	2	25869668
Pubmed	A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure.	PRICKLE2 EPHA7	7.19e-05	13	34	2	26989192
Pubmed	The HIV proteins Tat and Nef promote human bone marrow mesenchymal stem cell senescence and alter osteoblastic differentiation.	RELA ULK1	7.19e-05	13	34	2	25847297
Pubmed	Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure.	CYP11B1 SRD5A1	1.10e-04	16	34	2	37727456
Pubmed	Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.	CSMD1 APOH	1.57e-04	19	34	2	24165912
Pubmed	Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones.	CYP11B1 SRD5A1	4.24e-04	31	34	2	15583024
Pubmed	Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer.	CYP11B1 SRD5A1	6.38e-04	38	34	2	20214802
Pubmed	Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).	PTPRN2 SRD5A1	6.38e-04	38	34	2	22952603
Pubmed	Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.	RFK CSMD1	6.72e-04	39	34	2	19010793
Pubmed	Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination.	ULK1 NUP160	9.75e-04	47	34	2	26687681
Cytoband	19p13.2	ZNF799 ZNF443 ZNF426 ZNF563	2.49e-05	229	34	4	19p13.2
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CSMD1 APOH	3.50e-03	57	28	2	1179
Drug	azotochelin	ERCC6 PGBD3	2.16e-06	2	34	2	CID000193592
Disease	blood manganese measurement	INPP5F CSMD1 FREM3	3.33e-06	27	32	3	EFO_0007581
Disease	clostridium difficile infection	ZNF799 GRIK5 CSMD1 EPHA7	1.76e-05	144	32	4	EFO_0009130
Disease	aspartate aminotransferase measurement	ZMAT4 INPP5F CSMD1 APOH ERAP2 NUP160 CYP11B1	4.26e-05	904	32	7	EFO_0004736
Disease	glycodeoxycholate measurement	GRIK5 CSMD1	1.03e-04	14	32	2	EFO_0010493
Disease	granulysin measurement	ERAP2 CYP11B1	1.19e-04	15	32	2	EFO_0008144
Disease	cortical thickness change measurement	CSMD1 EPHA7	1.72e-04	18	32	2	EFO_0021501
Disease	malaria	KLHL3 CSMD1 FREM3	1.85e-04	102	32	3	EFO_0001068
Disease	mood instability measurement	LAMB2 CSMD1 NUP160	3.61e-04	128	32	3	EFO_0008475
Disease	neuritic plaque measurement	GRIK5 CSMD1 INPP4A ZNF443	5.32e-04	349	32	4	EFO_0006798
Disease	aggressive behaviour measurement, childhood aggressive behaviour measurement	ZMAT4 CSMD1	5.54e-04	32	32	2	EFO_0007663, EFO_0007826
Disease	cognitive function measurement, self reported educational attainment	ZNF799 PTPRN2 NUP160 ZNF443	5.68e-04	355	32	4	EFO_0004784, EFO_0008354
Disease	attempted suicide	CSMD1 CD200R1 EPHA7	9.41e-04	178	32	3	EFO_0004321
Disease	diffuse plaque measurement	ZMAT4 GRIK5 PTPRN2 CD200R1 EPHA7	1.25e-03	758	32	5	EFO_0010699
Disease	severe acute respiratory syndrome, COVID-19	PRICKLE2 ZMAT4 CSMD1 EPHA7	1.34e-03	447	32	4	EFO_0000694, MONDO_0100096
Disease	response to cisplatin, platinum measurement	CSMD1 PTPRN2	1.52e-03	53	32	2	EFO_0010154, GO_0072718
Disease	behavior	ZMAT4 PTPRN2	1.63e-03	55	32	2	GO_0007610
Disease	creatine kinase measurement	APOH CYP11B1	1.88e-03	59	32	2	EFO_0004534
Disease	parental longevity	PRICKLE2 LAMB2 CSMD1 EPHA7	1.92e-03	494	32	4	EFO_0007796
Disease	non-lobar intracerebral hemorrhage	PTPRN2 NUP160	2.14e-03	63	32	2	EFO_0010178

Protein segments in the cluster

Peptide	Gene	Start	Entry
CKPGYVSRGGMRKFI	APOH	51	P02749
VGSKVHYFCKPGYRM	CSMD1	2451	Q96PZ7
FPKRGQTCVVHYTGM	FKBP1A	16	P62942
LKSVFGGAICRMYRF	INPP4A	221	Q96PE3
GVFGRCQKVPAMDFY	PTPRN2	56	Q92932
YVRGHGKLRFAPRMC	KCNG3	76	Q8TAE7
MVPYFGRHGCKQFIR	ERCC6	741	P0DP91
MAICQHFYKRGNIYP	MCOLN3	156	Q8TDD5
HMVGRRCEQVQPGYF	LAMB2	546	P55268
RCIMVTPDGNFHRGY	CD200R1	131	Q8TD46
FMVFGFIIGRRHCGY	EPHA7	571	Q15375
CRVLRPGGAFYFMEH	METTL7A	161	Q9H8H3
AILMHFPFCGPRKVY	OR2AE1	161	Q8NHA4
GQRYIMKEGRPYCCH	PRICKLE2	231	Q7Z3G6
FYLVGKRCMEIFGPR	GJB4	206	Q9NTQ9
RNFYHVPFGFGMRQC	CYP11B1	436	P15538
HRKPMFNIHRGFYCL	ERAP2	11	Q6P179
RRCRAGVVFMAGHVY	KLHL3	336	Q9UH77
RVHMGRKPGYFSFLD	GRIK5	526	Q16478
GFAKPMDIYCHRFVQ	INPP5F	951	Q9Y2H2
EFMVPYFGRHGCKQF	PGBD3	271	Q8N328
GPQHGHLQYFKRCMV	FREM3	871	P0C091
HLQYFKRCMVPGESF	FREM3	876	P0C091
LGHKAGCRHRFMEPY	MRPS2	91	Q9Y399
LGIYMHAPKRGQFCI	NUP160	356	Q12769
RHMAVQRGDGPYKCK	ZNF799	186	Q96GE5
LCYVKMPSFQHGPGR	TTTY12	51	Q9BZ98
IPTCMGFGVHQDKYR	VRK3	241	Q8IV63
MRHLPYFCRGQVVRG	RFK	1	Q969G6
RHMVVQGGNRPYKCK	ZNF563	186	Q8TA94
RHMAVQRGDGPYKCK	ZNF443	186	Q9Y2A4
GHRCLIYPFLMRGGK	SRD5A1	96	P18405
QPKQRGMRFRYKCEG	RELA	26	Q04206
KVRLYYMLHPRDGGC	ZMAT4	41	Q9H898
GKVFGYPSCLNNHMR	ZNF426	426	Q9BUY5
MFQHREGCVPRYHKA	ULK1	996	O75385