Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH12 DNAH1	2.46e-04	18	26	2	GO:0008569
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH12 DNAH1	6.04e-04	28	26	2	GO:0051959
GeneOntologyMolecularFunction	ATP-dependent activity	DNAH12 RUVBL2 DHX37 SUPV3L1 DNAH1	1.04e-03	614	26	5	GO:0140657
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNAH12 DNAH1	1.06e-03	37	26	2	GO:0045505
GeneOntologyMolecularFunction	helicase activity	RUVBL2 DHX37 SUPV3L1	1.11e-03	158	26	3	GO:0004386
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	XRN1 RUVBL2 DHX37 SUPV3L1 POLH	1.30e-03	645	26	5	GO:0140640
GeneOntologyMolecularFunction	ATP hydrolysis activity	DNAH12 RUVBL2 DHX37 SUPV3L1	2.39e-03	441	26	4	GO:0016887
GeneOntologyMolecularFunction	polyubiquitin modification-dependent protein binding	ZBTB1 RAD23B	2.67e-03	59	26	2	GO:0031593
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	DNAH12 RUVBL2 TUBB8 DHX37 SUPV3L1	2.90e-03	775	26	5	GO:0017111
GeneOntologyMolecularFunction	DNA helicase activity	RUVBL2 SUPV3L1	2.94e-03	62	26	2	GO:0003678
GeneOntologyMolecularFunction	microtubule motor activity	DNAH12 DNAH1	3.73e-03	70	26	2	GO:0003777
GeneOntologyMolecularFunction	pyrophosphatase activity	DNAH12 RUVBL2 TUBB8 DHX37 SUPV3L1	4.08e-03	839	26	5	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	DNAH12 RUVBL2 TUBB8 DHX37 SUPV3L1	4.10e-03	840	26	5	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	DNAH12 RUVBL2 TUBB8 DHX37 SUPV3L1	4.10e-03	840	26	5	GO:0016818
GeneOntologyMolecularFunction	RNA helicase activity	DHX37 SUPV3L1	4.61e-03	78	26	2	GO:0003724
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	RUVBL2 SUPV3L1 POLH	4.64e-03	262	26	3	GO:0140097
GeneOntologyMolecularFunction	ATP-dependent activity, acting on RNA	DHX37 SUPV3L1	4.84e-03	80	26	2	GO:0008186
GeneOntologyMolecularFunction	damaged DNA binding	POLH RAD23B	5.32e-03	84	26	2	GO:0003684
GeneOntologyMolecularFunction	ubiquitin binding	MARK4 RAD23B	8.50e-03	107	26	2	GO:0043130
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNAH12 DNAH1	1.03e-02	118	26	2	GO:0003774
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	RUVBL2 SUPV3L1	1.18e-02	127	26	2	GO:0008094
GeneOntologyMolecularFunction	ubiquitin-like protein binding	MARK4 RAD23B	1.20e-02	128	26	2	GO:0032182
GeneOntologyBiologicalProcess	cilium movement involved in cell motility	RSPH3 DNAH12 TTLL6 DNAH1	1.52e-04	210	27	4	GO:0060294
GeneOntologyBiologicalProcess	cilium or flagellum-dependent cell motility	RSPH3 DNAH12 TTLL6 DNAH1	1.67e-04	215	27	4	GO:0001539
GeneOntologyBiologicalProcess	cilium-dependent cell motility	RSPH3 DNAH12 TTLL6 DNAH1	1.67e-04	215	27	4	GO:0060285
GeneOntologyBiologicalProcess	RNA surveillance	XRN1 SUPV3L1	2.49e-04	18	27	2	GO:0071025
GeneOntologyBiologicalProcess	cellular response to UV	RUVBL2 ZBTB1 POLH	2.72e-04	97	27	3	GO:0034644
GeneOntologyBiologicalProcess	microtubule-based process	RSPH3 DNAH12 TTLL6 TUBB8 IFT172 MARK4 DNAH1	3.29e-04	1058	27	7	GO:0007017
GeneOntologyBiologicalProcess	cilium movement	RSPH3 DNAH12 TTLL6 DNAH1	3.50e-04	261	27	4	GO:0003341
GeneOntologyBiologicalProcess	microtubule-based movement	RSPH3 DNAH12 TTLL6 IFT172 DNAH1	3.99e-04	493	27	5	GO:0007018
GeneOntologyBiologicalProcess	translesion synthesis	ZBTB1 POLH	5.26e-04	26	27	2	GO:0019985
GeneOntologyCellularComponent	inner dynein arm	DNAH12 DNAH1	7.18e-05	10	27	2	GO:0036156
GeneOntologyCellularComponent	alpha-beta T cell receptor complex	TRAC TRA	1.05e-04	12	27	2	GO:0042105
GeneOntologyCellularComponent	axoneme	RSPH3 DNAH12 IFT172 DNAH1	1.37e-04	207	27	4	GO:0005930
GeneOntologyCellularComponent	ciliary plasm	RSPH3 DNAH12 IFT172 DNAH1	1.40e-04	208	27	4	GO:0097014
GeneOntologyCellularComponent	9+2 motile cilium	RSPH3 DNAH12 IFT172 DNAH1	2.34e-04	238	27	4	GO:0097729
GeneOntologyCellularComponent	axonemal dynein complex	DNAH12 DNAH1	4.73e-04	25	27	2	GO:0005858
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	RSPH3 DNAH12 IFT172 DNAH1	6.91e-04	317	27	4	GO:0032838
GeneOntologyCellularComponent	cilium	RSPH3 DNAH12 TTLL6 IFT172 MARK4 DNAH1	8.42e-04	898	27	6	GO:0005929
GeneOntologyCellularComponent	motile cilium	RSPH3 DNAH12 IFT172 DNAH1	1.05e-03	355	27	4	GO:0031514
GeneOntologyCellularComponent	cytoplasmic region	RSPH3 DNAH12 IFT172 DNAH1	1.11e-03	360	27	4	GO:0099568
GeneOntologyCellularComponent	ciliary basal body	TTLL6 IFT172 MARK4	1.98e-03	195	27	3	GO:0036064
GeneOntologyCellularComponent	dynein complex	DNAH12 DNAH1	2.21e-03	54	27	2	GO:0030286
GeneOntologyCellularComponent	sperm flagellum	RSPH3 IFT172 DNAH1	2.58e-03	214	27	3	GO:0036126
GeneOntologyCellularComponent	small-subunit processome	DHX37 NGDN	4.32e-03	76	27	2	GO:0032040
GeneOntologyCellularComponent	microtubule	DNAH12 TTLL6 TUBB8 DNAH1	4.60e-03	533	27	4	GO:0005874
Domain	ATPase_dyneun-rel_AAA	DNAH12 DNAH1	1.68e-04	14	26	2	IPR011704
Domain	Dynein_heavy_chain_D4_dom	DNAH12 DNAH1	1.68e-04	14	26	2	IPR024317
Domain	Dynein_heavy_dom-2	DNAH12 DNAH1	1.68e-04	14	26	2	IPR013602
Domain	DHC_N2	DNAH12 DNAH1	1.68e-04	14	26	2	PF08393
Domain	AAA_8	DNAH12 DNAH1	1.68e-04	14	26	2	PF12780
Domain	AAA_5	DNAH12 DNAH1	1.68e-04	14	26	2	PF07728
Domain	DHC_fam	DNAH12 DNAH1	1.93e-04	15	26	2	IPR026983
Domain	Dynein_heavy_dom	DNAH12 DNAH1	1.93e-04	15	26	2	IPR004273
Domain	Dynein_heavy	DNAH12 DNAH1	1.93e-04	15	26	2	PF03028
Domain	UBA	MARK4 RAD23B	7.91e-04	30	26	2	SM00165
Domain	ATP_grasp_subdomain_2	ACACA TTLL6	8.45e-04	31	26	2	IPR013816
Domain	UBA	MARK4 RAD23B	1.14e-03	36	26	2	PF00627
Domain	UBA	MARK4 RAD23B	1.70e-03	44	26	2	IPR015940
Domain	UBA	MARK4 RAD23B	1.94e-03	47	26	2	PS50030
Domain	-	DNAH12 RUVBL2 DHX37 SUPV3L1 DNAH1	3.28e-03	746	26	5	3.40.50.300
Domain	P-loop_NTPase	DNAH12 RUVBL2 DHX37 SUPV3L1 DNAH1	5.66e-03	848	26	5	IPR027417
Domain	Helicase_C	DHX37 SUPV3L1	9.66e-03	107	26	2	PF00271
Domain	HELICc	DHX37 SUPV3L1	9.66e-03	107	26	2	SM00490
Domain	Helicase_C	DHX37 SUPV3L1	9.84e-03	108	26	2	IPR001650
Domain	HELICASE_CTER	DHX37 SUPV3L1	1.00e-02	109	26	2	PS51194
Domain	HELICASE_ATP_BIND_1	DHX37 SUPV3L1	1.00e-02	109	26	2	PS51192
Pathway	KEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT	DNAH12 TUBB8 DNAH1	1.74e-05	43	17	3	M47669
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH12 TUBB8 DNAH1	2.00e-05	45	17	3	M47670
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH12 DNAH1	4.72e-04	27	17	2	M47755
Pubmed	TRAC variants associate with IgA nephropathy.	TRAC TRA	5.80e-07	2	27	2	19470682
Pubmed	A structural basis for immunodominant human T cell receptor recognition.	TRAC TRA	5.80e-07	2	27	2	12796775
Pubmed	The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia.	TRAC TRA	5.80e-07	2	27	2	3875483
Pubmed	Patients with severe asthenoteratospermia carrying SPAG6 or RSPH3 mutations have a positive pregnancy outcome following intracytoplasmic sperm injection.	RSPH3 DNAH1	1.74e-06	3	27	2	32124190
Pubmed	The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance.	TRAC TRA	1.74e-06	3	27	2	12429093
Pubmed	Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line.	TRAC TRA	1.74e-06	3	27	2	3873654
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	ACACA TTLL6 TRA POLH	5.69e-06	152	27	4	34299191
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH12 DNAH1	1.22e-05	7	27	2	9256245
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	XRN1 ACACA RUVBL2 TUBB8 DHX37 VPS45	4.07e-05	853	27	6	28718761
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH12 DNAH1	5.25e-05	14	27	2	9373155
Pubmed	Tissue expression patterns identify mouse cilia genes.	RSPH3 TTLL6 IFT172	5.68e-05	96	27	3	17971504
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	XRN1 RNF10 C5orf34 RUVBL2 ZBTB1 TUBB8	1.20e-04	1038	27	6	26673895
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	XRN1 TRAF3IP2 RUVBL2 DHX37 SUPV3L1	1.29e-04	650	27	5	38777146
Pubmed	Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.	TRAC TRA	1.59e-04	24	27	2	15489916
Pubmed	siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.	ACACA POLH	1.86e-04	26	27	2	23435420
Pubmed	Adapters in lymphocyte signaling.	TRAC TRA	1.86e-04	26	27	2	11827988
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	XRN1 ACACA RUVBL2 DHX37 NGDN	2.13e-04	724	27	5	36232890
Pubmed	The mechanism of phospholipase C-gamma1 regulation.	TRAC TRA	2.66e-04	31	27	2	11048639
Pubmed	Primary Ciliary Dyskinesia	RSPH3 DNAH1	2.84e-04	32	27	2	20301301
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	XRN1 ACACA ZBTB1 POLH	2.90e-04	418	27	4	34709266
Pubmed	BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.	TUBB8 DHX37 SUPV3L1 IFT172	2.93e-04	419	27	4	33001583
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	RUVBL2 DHX37 MFF NGDN RAD23B	4.38e-04	847	27	5	35850772
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	XRN1 ACACA RUVBL2 DHX37 SUPV3L1 NGDN	5.02e-04	1353	27	6	29467282
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	XRN1 ACACA DHX37	5.86e-04	212	27	3	33853758
Pubmed	Multiple mouse chromosomal loci for dynein-based motility.	DNAH12 DNAH1	6.14e-04	47	27	2	8812413
Pubmed	Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.	XRN1 RNF10 RUVBL2	6.79e-04	223	27	3	20020773
Pubmed	Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne.	POLH RAD23B	6.95e-04	50	27	2	31699778
Interaction	MLH1 interactions	XRN1 RSPH3 RUVBL2 POLH RAD23B	1.62e-05	244	27	5	int:MLH1
Cytoband	12q24.31	RNF10 DHX37	1.02e-03	80	27	2	12q24.31
Cytoband	19q13.3	RUVBL2 MARK4	1.07e-03	82	27	2	19q13.3
GeneFamily	Dyneins, axonemal	DNAH12 DNAH1	1.12e-04	17	17	2	536
GeneFamily	T-cell receptor alpha locus at 14q11.2	TRAC TRA	5.30e-03	117	17	2	371
Coexpression	GSE14000_UNSTIM_VS_16H_LPS_DC_TRANSLATED_RNA_UP	RUVBL2 VPS45 SUPV3L1 MFF	4.06e-05	197	26	4	M3343
Coexpression	GSE27786_BCELL_VS_ERYTHROBLAST_UP	TRAF3IP2 RUVBL2 VPS45 IFT172	4.31e-05	200	26	4	M4810
Coexpression	DESCARTES_MAIN_FETAL_CILIATED_EPITHELIAL_CELLS	RSPH3 DNAH12 RUVBL2 TTLL6 IFT172 DNAH1	4.34e-05	678	26	6	M40124
Disease	Polynesian Bronchiectasis	RSPH3 DNAH1	4.71e-04	35	27	2	C4317124
Disease	Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus	RSPH3 DNAH1	4.71e-04	35	27	2	C4551906
Disease	Kartagener Syndrome	RSPH3 DNAH1	4.71e-04	35	27	2	C0022521
Disease	Primary ciliary dyskinesia	RSPH3 DNAH1	4.98e-04	36	27	2	cv:C0008780
Disease	Primary Ciliary Dyskinesia	RSPH3 DNAH1	8.50e-04	47	27	2	C4551720
Disease	interleukin 12 measurement	POLH RAD23B	1.08e-03	53	27	2	EFO_0004753
Disease	vascular endothelial growth factor measurement	POLH RAD23B	1.20e-03	56	27	2	EFO_0004762
Disease	aspartate aminotransferase to alanine aminotransferase ratio	HMGXB3 SUPV3L1 MARK4	1.33e-03	239	27	3	EFO_0010934

Protein segments in the cluster

Peptide	Gene	Start	Entry
SKIEESVRSMVMRYG	ACACA	1486	Q13085
ENMVTEIMSMGYERE	RAD23B	191	P54727
RIETKGQYDEEEMTM	DSG3	26	P32926
ERAKREMVMYSITVA	MFF	316	Q9GZY8
MDASYDGTEVTVVME	HMGXB3	1	Q12766
EMMDLISYVEKARTV	DNAH12	526	Q6ZR08
KTEVMVMEGVTTVAY	IFT172	576	Q9UG01
ITSESKMMQVIEEYI	DNAH1	2531	Q9P2D7
EVMVGMGYTREEIKE	MARK4	336	Q96L34
TDGTMIYMESGIVKI	C5orf34	111	Q96MH7
VETTKMYMKGVSSVE	DHX37	986	Q8IY37
VALMEKRMSEYITTA	RUNDC3A	131	Q59EK9
TEMETIYDLGTKMIE	RUVBL2	166	Q9Y230
KYREASVEVMEIMSR	POLH	91	Q9Y253
IDLVMELMYTTGEEV	SUPV3L1	326	Q8IYB8
VYITDKTVLDMRSMD	TRAC	41	P01848
KVFITYSMDTAMEVV	TRAF3IP2	411	O43734
EVEKTMEYSMVGRTV	RSPH3	441	Q86UC2
YEESMMVRLSVSKRE	NGDN	241	Q8NEJ9
YTEGAELMESVMDVV	TUBB8	106	Q3ZCM7
VYITDKTVLDMRSMD	TRA	176	P0DTU3
YVVGDTITMQLMKRE	RNF10	286	Q8N5U6
TYYMTKMGVDVVSDD	XRN1	436	Q8IZH2
MMHKSYIEVTEEGTE	SERPINB7	321	O75635
LMDKETTGIVSMVYT	VPS45	26	Q9NRW7
TDYSVSLERVMEMKS	TTLL6	96	Q8N841
SKMIFGVRMYEDTVA	ZBTB1	136	Q9Y2K1