Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	signaling receptor complex adaptor activity	GNB4 GNB1 GNB2 GNB3	3.66e-06	54	39	4	GO:0030159
GeneOntologyMolecularFunction	signaling adaptor activity	GNB4 GNB1 GNB2 GNB3	1.15e-04	129	39	4	GO:0035591
GeneOntologyCellularComponent	heterotrimeric G-protein complex	GNB4 GNB1 GNB2 GNB3	5.19e-07	35	39	4	GO:0005834
GeneOntologyCellularComponent	GTPase complex	GNB4 GNB1 GNB2 GNB3	9.97e-07	41	39	4	GO:1905360
GeneOntologyCellularComponent	extrinsic component of cytoplasmic side of plasma membrane	GNB4 GNB1 GNB2 GNB3	3.54e-06	56	39	4	GO:0031234
GeneOntologyCellularComponent	myelin sheath	NFASC GNB4 GNB1 GNB2 SDHA	4.97e-05	217	39	5	GO:0043209
GeneOntologyCellularComponent	extrinsic component of plasma membrane	GNB4 GNB1 GNB2 GNB3	1.22e-04	137	39	4	GO:0019897
GeneOntologyCellularComponent	cytoplasmic side of plasma membrane	GNB4 GNB1 GNB2 GNB3	3.83e-04	185	39	4	GO:0009898
GeneOntologyCellularComponent	ciliary membrane	TSPEAR GNB1 PKD1	8.08e-04	98	39	3	GO:0060170
GeneOntologyCellularComponent	cytoplasmic side of membrane	GNB4 GNB1 GNB2 GNB3	8.68e-04	230	39	4	GO:0098562
GeneOntologyCellularComponent	extrinsic component of membrane	GNB4 GNB1 GNB2 GNB3	8.68e-04	230	39	4	GO:0019898
GeneOntologyCellularComponent	vacuolar membrane	GNB4 ABCA3 GNB1 GNB2 SLC22A17	2.40e-03	507	39	5	GO:0005774
Domain	Guanine_nucleotide-bd_bsu	GNB4 GNB1 GNB2 GNB3	6.51e-11	5	37	4	IPR016346
Domain	Gprotein_B	GNB4 GNB1 GNB2 GNB3	2.71e-09	10	37	4	IPR001632
Domain	RFX1_trans_act	RFX1 RFX2 RFX3	7.16e-09	3	37	3	IPR007668
Domain	RFX1_trans_act	RFX1 RFX2 RFX3	7.16e-09	3	37	3	PF04589
Domain	RFX_DNA_binding	RFX1 RFX2 RFX3	5.96e-07	9	37	3	PF02257
Domain	DNA-bd_RFX	RFX1 RFX2 RFX3	5.96e-07	9	37	3	IPR003150
Domain	RFX_DBD	RFX1 RFX2 RFX3	5.96e-07	9	37	3	PS51526
Domain	WD40	GNB4 DCAF6 GNB1 GNB2 GNB3 RFWD3	1.09e-05	259	37	6	PF00400
Domain	WD40	GNB4 DCAF6 GNB1 GNB2 GNB3 RFWD3	1.32e-05	268	37	6	SM00320
Domain	WD40_repeat	GNB4 DCAF6 GNB1 GNB2 GNB3 RFWD3	1.44e-05	272	37	6	IPR001680
Domain	WD_REPEATS_1	GNB4 DCAF6 GNB1 GNB2 GNB3 RFWD3	1.63e-05	278	37	6	PS00678
Domain	WD_REPEATS_2	GNB4 DCAF6 GNB1 GNB2 GNB3 RFWD3	1.66e-05	279	37	6	PS50082
Domain	WD_REPEATS_REGION	GNB4 DCAF6 GNB1 GNB2 GNB3 RFWD3	1.66e-05	279	37	6	PS50294
Domain	G-protein_beta_WD-40_rep	GNB4 GNB1 GNB2 GNB3	2.35e-05	85	37	4	IPR020472
Domain	WD40_repeat_dom	GNB4 DCAF6 GNB1 GNB2 GNB3 RFWD3	2.36e-05	297	37	6	IPR017986
Domain	-	GNB4 DCAF6 GNB1 GNB2 GNB3 RFWD3	4.48e-05	333	37	6	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	GNB4 DCAF6 GNB1 GNB2 GNB3 RFWD3	4.63e-05	335	37	6	IPR015943
Domain	RA	MYO9A RASSF2 SNX17	5.31e-05	37	37	3	PS50200
Domain	RA_dom	MYO9A RASSF2 SNX17	6.72e-05	40	37	3	IPR000159
Domain	PKD	SORCS1 PKD1	7.97e-05	7	37	2	PF00801
Domain	PKD/Chitinase_dom	SORCS1 PKD1	1.36e-04	9	37	2	IPR022409
Domain	PKD	SORCS1 PKD1	1.36e-04	9	37	2	SM00089
Domain	PKD	SORCS1 PKD1	2.08e-04	11	37	2	PS50093
Domain	PKD_dom	SORCS1 PKD1	2.08e-04	11	37	2	IPR000601
Domain	-	SORCS1 PKD1	2.08e-04	11	37	2	2.60.40.670
Domain	FERM-adjacent	EPB41L5 EPB41L4B	2.94e-04	13	37	2	IPR014847
Domain	FA	EPB41L5 EPB41L4B	2.94e-04	13	37	2	SM01195
Domain	FA	EPB41L5 EPB41L4B	2.94e-04	13	37	2	PF08736
Domain	WD40_repeat_CS	GNB4 GNB1 GNB2 GNB3	3.02e-04	164	37	4	IPR019775
Domain	Ubiquitin-rel_dom	EPB41L5 EPB41L4B MYO9A RASSF2	4.67e-04	184	37	4	IPR029071
Domain	IQ	ASPM DCAF6 MYO9A	5.49e-04	81	37	3	SM00015
Domain	IQ_motif_EF-hand-BS	ASPM DCAF6 MYO9A	7.47e-04	90	37	3	IPR000048
Domain	Ez/rad/moesin-like	EPB41L5 EPB41L4B	7.83e-04	21	37	2	IPR000798
Domain	IQ	ASPM DCAF6 MYO9A	8.21e-04	93	37	3	PS50096
Domain	FERM_CS	EPB41L5 EPB41L4B	1.03e-03	24	37	2	IPR019747
Domain	FERM_C	EPB41L5 EPB41L4B	1.20e-03	26	37	2	PF09380
Domain	FERM_C	EPB41L5 EPB41L4B	1.30e-03	27	37	2	SM01196
Domain	FERM_PH-like_C	EPB41L5 EPB41L4B	1.30e-03	27	37	2	IPR018980
Domain	RA	MYO9A RASSF2	1.71e-03	31	37	2	SM00314
Domain	FERM_N	EPB41L5 EPB41L4B	1.94e-03	33	37	2	PF09379
Domain	FERM_N	EPB41L5 EPB41L4B	1.94e-03	33	37	2	IPR018979
Domain	RA	MYO9A RASSF2	2.31e-03	36	37	2	PF00788
Domain	FERM_M	EPB41L5 EPB41L4B	3.74e-03	46	37	2	PF00373
Domain	-	EPB41L5 EPB41L4B	4.24e-03	49	37	2	1.20.80.10
Domain	FERM_central	EPB41L5 EPB41L4B	4.24e-03	49	37	2	IPR019748
Domain	FERM_domain	EPB41L5 EPB41L4B	4.24e-03	49	37	2	IPR000299
Domain	FERM_1	EPB41L5 EPB41L4B	4.41e-03	50	37	2	PS00660
Domain	FERM_2	EPB41L5 EPB41L4B	4.41e-03	50	37	2	PS00661
Domain	FERM_3	EPB41L5 EPB41L4B	4.41e-03	50	37	2	PS50057
Domain	Band_41_domain	EPB41L5 EPB41L4B	4.41e-03	50	37	2	IPR019749
Domain	B41	EPB41L5 EPB41L4B	4.41e-03	50	37	2	SM00295
Domain	FERM/acyl-CoA-bd_prot_3-hlx	EPB41L5 EPB41L4B	4.41e-03	50	37	2	IPR014352
Pathway	REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS	SCTR GNB4 GNB1 GNB2 GNB3	7.00e-09	33	30	5	MM15066
Pathway	REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS	SCTR GNB4 GNB1 GNB2 GNB3	7.00e-09	33	30	5	M10322
Pathway	REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR	GNB4 GNB1 GNB2 GNB3	6.32e-08	19	30	4	MM15021
Pathway	REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR	GNB4 GNB1 GNB2 GNB3	6.32e-08	19	30	4	M926
Pathway	REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_CDC42	GNB4 GNB1 GNB2 GNB3	7.88e-08	20	30	4	M27853
Pathway	REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_CDC42	GNB4 GNB1 GNB2 GNB3	7.88e-08	20	30	4	MM15572
Pathway	REACTOME_PRESYNAPTIC_FUNCTION_OF_KAINATE_RECEPTORS	GNB4 GNB1 GNB2 GNB3	9.72e-08	21	30	4	M27409
Pathway	REACTOME_PRESYNAPTIC_FUNCTION_OF_KAINATE_RECEPTORS	GNB4 GNB1 GNB2 GNB3	9.72e-08	21	30	4	MM15159
Pathway	REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_12	GNB4 GNB1 GNB2 GNB3	1.19e-07	22	30	4	MM15016
Pathway	REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_12	GNB4 GNB1 GNB2 GNB3	1.19e-07	22	30	4	M841
Pathway	REACTOME_ADRENALINE_NORADRENALINE_INHIBITS_INSULIN_SECRETION	GNB4 GNB1 GNB2 GNB3	1.43e-07	23	30	4	MM15033
Pathway	KEGG_MEDICUS_REFERENCE_LPAR_GNB_G_RHO_SIGNALING_PATHWAY	GNB4 GNB1 GNB2 GNB3	1.43e-07	23	30	4	M47549
Pathway	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS	SCTR GNB4 GNB1 GNB2 GNB3	1.55e-07	60	30	5	MM14964
Pathway	REACTOME_G_PROTEIN_ACTIVATION	GNB4 GNB1 GNB2 GNB3	1.72e-07	24	30	4	M13115
Pathway	REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR	GNB4 GNB1 GNB2 GNB3	1.72e-07	24	30	4	M18308
Pathway	REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR	GNB4 GNB1 GNB2 GNB3	1.72e-07	24	30	4	MM15088
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_VGPCR_TO_GNB_G_PI3K_AKT_SIGNALING_PATHWAY	GNB4 GNB1 GNB2 GNB3	1.72e-07	24	30	4	M47460
Pathway	REACTOME_G_PROTEIN_ACTIVATION	GNB4 GNB1 GNB2 GNB3	1.72e-07	24	30	4	MM14794
Pathway	REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA	GNB4 GNB1 GNB2 GNB3	2.04e-07	25	30	4	M14301
Pathway	REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_1	GNB4 GNB1 GNB2 GNB3	2.04e-07	25	30	4	MM15056
Pathway	REACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_1	GNB4 GNB1 GNB2 GNB3	2.04e-07	25	30	4	M811
Pathway	REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA	GNB4 GNB1 GNB2 GNB3	2.41e-07	26	30	4	MM15017
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNB_G_RAC_SIGNALING_PATHWAY	GNB4 GNB1 GNB2 GNB3	2.41e-07	26	30	4	M47561
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNB_G_RAC_SIGNALING_PATHWAY	GNB4 GNB1 GNB2 GNB3	2.41e-07	26	30	4	M47562
Pathway	KEGG_MEDICUS_REFERENCE_CCR5_GNB_G_PLCB_G_PKC_SIGNALING_PATHWAY	GNB4 GNB1 GNB2 GNB3	2.41e-07	26	30	4	M47557
Pathway	KEGG_MEDICUS_REFERENCE_CXCR_GNB_G_PI3K_AKT_SIGNALING_PATHWAY	GNB4 GNB1 GNB2 GNB3	2.41e-07	26	30	4	M47456
Pathway	KEGG_MEDICUS_REFERENCE_CXCR_GNB_G_ERK_SIGNALING_PATHWAY	GNB4 GNB1 GNB2 GNB3	2.83e-07	27	30	4	M47454
Pathway	REACTOME_GPER1_SIGNALING	GNB4 GNB1 GNB2 GNB3	2.83e-07	27	30	4	MM15664
Pathway	REACTOME_ADRENALINE_NORADRENALINE_INHIBITS_INSULIN_SECRETION	GNB4 GNB1 GNB2 GNB3	3.29e-07	28	30	4	M10679
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_VGPCR_TO_GNB_G_PI3K_JNK_SIGNALING_PATHWAY	GNB4 GNB1 GNB2 GNB3	3.81e-07	29	30	4	M47466
Pathway	REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING	GNB4 GNB1 GNB2 GNB3	4.39e-07	30	30	4	M18193
Pathway	REACTOME_ACTIVATION_OF_G_PROTEIN_GATED_POTASSIUM_CHANNELS	GNB4 GNB1 GNB2 GNB3	4.39e-07	30	30	4	MM14542
Pathway	REACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS	GNB4 GNB1 GNB2 GNB3	5.04e-07	31	30	4	MM15094
Pathway	KEGG_MEDICUS_REFERENCE_CXCR4_GNB_G_PLCB_PKC_SIGNALING_PATHWAY	GNB4 GNB1 GNB2 GNB3	5.04e-07	31	30	4	M47554
Pathway	KEGG_MEDICUS_REFERENCE_CCR_CXCR_GNB_G_PI3K_RAC_SIGNALING_PATHWAY	GNB4 GNB1 GNB2 GNB3	5.04e-07	31	30	4	M47455
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_VGPCR_TO_GNB_G_ERK_SIGNALING_PATHWAY	GNB4 GNB1 GNB2 GNB3	5.04e-07	31	30	4	M47459
Pathway	KEGG_MEDICUS_REFERENCE_CCR2_GNB_G_PI3K_NFKB_SIGNALING_PATHWAY	GNB4 GNB1 GNB2 GNB3	5.04e-07	31	30	4	M47540
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_US28_TO_GNB_G_PI3K_NFKB_SIGNALING_PATHWAY	GNB4 GNB1 GNB2 GNB3	5.04e-07	31	30	4	M47541
Pathway	REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING	GNB4 GNB1 GNB2 GNB3	5.75e-07	32	30	4	M14309
Pathway	REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS	GNB4 GNB1 GNB2 GNB3	5.75e-07	32	30	4	MM15148
Pathway	REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING	GNB4 GNB1 GNB2 GNB3	5.75e-07	32	30	4	MM15143
Pathway	KEGG_MEDICUS_REFERENCE_GPCR_PI3K_SIGNALING_PATHWAY	GNB4 GNB1 GNB2 GNB3	5.75e-07	32	30	4	M47962
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	GNB4 GNB1 GNB2 GNB3	5.75e-07	32	30	4	MM14983
Pathway	REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS	GNB4 GNB1 GNB2 GNB3	5.75e-07	32	30	4	M861
Pathway	REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING	GNB4 GNB1 GNB2 GNB3	6.53e-07	33	30	4	MM15027
Pathway	REACTOME_SIGNAL_AMPLIFICATION	GNB4 GNB1 GNB2 GNB3	6.53e-07	33	30	4	MM15020
Pathway	REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	GNB4 GNB1 GNB2 GNB3	6.53e-07	33	30	4	MM15058
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNB_G_RHO_SIGNALING_PATHWAY	GNB4 GNB1 GNB2 GNB3	6.53e-07	33	30	4	M47550
Pathway	REACTOME_SIGNAL_AMPLIFICATION	GNB4 GNB1 GNB2 GNB3	6.53e-07	33	30	4	M9379
Pathway	REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION	GNB4 GNB1 GNB2 GNB3	6.53e-07	33	30	4	M11575
Pathway	REACTOME_INWARDLY_RECTIFYING_K_CHANNELS	GNB4 GNB1 GNB2 GNB3	8.33e-07	35	30	4	M1075
Pathway	REACTOME_INWARDLY_RECTIFYING_K_CHANNELS	GNB4 GNB1 GNB2 GNB3	9.36e-07	36	30	4	MM14544
Pathway	REACTOME_COOPERATION_OF_PDCL_PHLP1_AND_TRIC_CCT_IN_G_PROTEIN_BETA_FOLDING	GNB4 GNB1 GNB2 GNB3	1.17e-06	38	30	4	M27656
Pathway	REACTOME_CHAPERONIN_MEDIATED_PROTEIN_FOLDING	GNB4 GNB1 GNB2 GNB3	1.30e-06	39	30	4	MM15003
Pathway	REACTOME_AQUAPORIN_MEDIATED_TRANSPORT	GNB4 GNB1 GNB2 GNB3	1.44e-06	40	30	4	MM15115
Pathway	REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS	SCTR GNB4 GNB1 GNB2 GNB3	1.48e-06	94	30	5	M797
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	GNB4 GNB1 GNB2 GNB3	1.76e-06	42	30	4	M791
Pathway	REACTOME_ADORA2B_MEDIATED_ANTI_INFLAMMATORY_CYTOKINES_PRODUCTION	GNB4 GNB1 GNB2 GNB3	1.94e-06	43	30	4	M29837
Pathway	REACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS	GNB4 GNB1 GNB2 GNB3	1.94e-06	43	30	4	M933
Pathway	REACTOME_GABA_B_RECEPTOR_ACTIVATION	GNB4 GNB1 GNB2 GNB3	1.94e-06	43	30	4	M954
Pathway	REACTOME_GABA_B_RECEPTOR_ACTIVATION	GNB4 GNB1 GNB2 GNB3	2.13e-06	44	30	4	MM15709
Pathway	REACTOME_CA2_PATHWAY	GNB4 GNB1 GNB2 GNB3	2.34e-06	45	30	4	MM15040
Pathway	REACTOME_GPER1_SIGNALING	GNB4 GNB1 GNB2 GNB3	2.34e-06	45	30	4	M45008
Pathway	REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	GNB4 GNB1 GNB2 GNB3	3.04e-06	48	30	4	M10775
Pathway	REACTOME_AQUAPORIN_MEDIATED_TRANSPORT	GNB4 GNB1 GNB2 GNB3	4.20e-06	52	30	4	M920
Pathway	REACTOME_GABA_RECEPTOR_ACTIVATION	GNB4 GNB1 GNB2 GNB3	7.48e-06	60	30	4	M976
Pathway	REACTOME_GABA_RECEPTOR_ACTIVATION	GNB4 GNB1 GNB2 GNB3	7.48e-06	60	30	4	MM15708
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	GNB4 GNB1 GNB2 GNB3	7.99e-06	61	30	4	MM15071
Pathway	REACTOME_CA2_PATHWAY	GNB4 GNB1 GNB2 GNB3	8.53e-06	62	30	4	M27321
Pathway	REACTOME_G_ALPHA_S_SIGNALLING_EVENTS	SCTR GNB4 GNB1 GNB2 GNB3	1.16e-05	143	30	5	MM15055
Pathway	REACTOME_OPIOID_SIGNALLING	GNB4 GNB1 GNB2 GNB3	1.47e-05	71	30	4	MM14491
Pathway	REACTOME_EXTRA_NUCLEAR_ESTROGEN_SIGNALING	GNB4 GNB1 GNB2 GNB3	1.47e-05	71	30	4	MM15590
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	GNB4 GNB1 GNB2 GNB3	1.55e-05	72	30	4	MM14631
Pathway	REACTOME_EXTRA_NUCLEAR_ESTROGEN_SIGNALING	GNB4 GNB1 GNB2 GNB3	1.82e-05	75	30	4	M27874
Pathway	REACTOME_G_ALPHA_S_SIGNALLING_EVENTS	SCTR GNB4 GNB1 GNB2 GNB3	1.83e-05	157	30	5	M4904
Pathway	REACTOME_PLATELET_HOMEOSTASIS	GNB4 GNB1 GNB2 GNB3	1.92e-05	76	30	4	MM15051
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	GNB4 GNB1 GNB2 GNB3	2.02e-05	77	30	4	MM15044
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	GNB4 GNB1 GNB2 GNB3	2.13e-05	78	30	4	M1921
Pathway	REACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS	GNB4 GNB1 GNB2 GNB3	2.36e-05	80	30	4	M800
Pathway	REACTOME_PLATELET_HOMEOSTASIS	GNB4 GNB1 GNB2 GNB3	3.13e-05	86	30	4	M916
Pathway	REACTOME_OPIOID_SIGNALLING	GNB4 GNB1 GNB2 GNB3	3.75e-05	90	30	4	M6467
Pathway	WP_ALSTROM_SYNDROME	RFX1 RFX2 RFX3	4.98e-05	34	30	3	M45524
Pathway	REACTOME_PROTEIN_FOLDING	GNB4 GNB1 GNB2 GNB3	5.24e-05	98	30	4	M776
Pathway	REACTOME_POTASSIUM_CHANNELS	GNB4 GNB1 GNB2 GNB3	5.24e-05	98	30	4	MM14545
Pathway	REACTOME_POTASSIUM_CHANNELS	GNB4 GNB1 GNB2 GNB3	6.36e-05	103	30	4	M1073
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	GNB4 GNB1 GNB2 GNB3	7.66e-05	108	30	4	M17034
Pathway	REACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING	GNB4 GNB1 GNB2 GNB3	1.27e-04	123	30	4	MM14988
Pathway	REACTOME_ESR_MEDIATED_SIGNALING	GNB4 GNB1 GNB2 GNB3	1.72e-04	133	30	4	MM15529
Pathway	REACTOME_ANTI_INFLAMMATORY_RESPONSE_FAVOURING_LEISHMANIA_PARASITE_INFECTION	GNB4 GNB1 GNB2 GNB3	1.77e-04	134	30	4	M29840
Pathway	REACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION	GNB4 GNB1 GNB2 GNB3	2.33e-04	144	30	4	MM14501
Pathway	REACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING	GNB4 GNB1 GNB2 GNB3	2.45e-04	146	30	4	M27288
Pathway	REACTOME_GPCR_LIGAND_BINDING	SCTR NLN GNB4 GNB1 GNB2 GNB3	2.48e-04	430	30	6	MM15160
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	GNB4 GNB1 GNB2 GNB3	2.79e-04	151	30	4	M39329
Pathway	REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION	GNB1 GNB3	2.85e-04	12	30	2	MM15036
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	GNB4 GNB1 GNB2 GNB3	3.16e-04	156	30	4	M39475
Pathway	REACTOME_GPCR_LIGAND_BINDING	SCTR NLN GNB4 GNB1 GNB2 GNB3	3.69e-04	463	30	6	M507
Pathway	WP_CHEMOKINE_SIGNALING	GNB4 GNB1 GNB2 GNB3	3.91e-04	165	30	4	M39400
Pathway	WP_FOCAL_ADHESION_PI3KAKTMTORSIGNALING	EPOR GNB4 GNB1 GNB2 GNB3	4.01e-04	302	30	5	M39719
Pathway	WP_RAS_SIGNALING	GNB4 GNB1 GNB2 GNB3	5.90e-04	184	30	4	M39764
Pathway	KEGG_CHEMOKINE_SIGNALING_PATHWAY	GNB4 GNB1 GNB2 GNB3	6.40e-04	188	30	4	M4844
Pubmed	Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA.	GNB4 GNB1 GNB2 GNB3	1.35e-12	4	39	4	1543505
Pubmed	The role of G protein beta subunits in the release of ATP from human erythrocytes.	GNB4 GNB1 GNB2 GNB3	1.35e-12	4	39	4	12512701
Pubmed	Identification of Gnr1p, a negative regulator of G alpha signalling in Schizosaccharomyces pombe, and its complementation by human G beta subunits.	GNB4 GNB1 GNB2 GNB3	2.02e-11	6	39	4	16884933
Pubmed	The gene for the beta-subunit of retinal transducin (Gnb-1) maps to distal mouse chromosome 4, and related sequences map to mouse chromosomes 5 and 8.	GNB4 GNB1 GNB2 GNB3	9.42e-11	8	39	4	2328987
Pubmed	Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.	GNB4 GNB1 GNB2 GNB3	1.69e-10	9	39	4	10339615
Pubmed	Gβ2 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Neocortex.	GNB4 GNB1 GNB2 GNB3	2.82e-10	10	39	4	28334111
Pubmed	Expression of olfactory receptors, G-proteins and AxCAMs during the development and maturation of olfactory sensory neurons in the mouse.	GNB4 GNB1 GNB2 GNB3	2.82e-10	10	39	4	9733924
Pubmed	A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation.	GNB4 GNB1 GNB2 GNB3	4.43e-10	11	39	4	25982117
Pubmed	The G protein subunit gene families.	GNB4 GNB1 GNB2 GNB3	4.43e-10	11	39	4	10644457
Pubmed	Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice.	GNB4 GNB1 GNB2 GNB3	6.64e-10	12	39	4	20186915
Pubmed	Differential sensitivity of P-Rex1 to isoforms of G protein betagamma dimers.	GNB4 GNB1 GNB2 GNB3	6.64e-10	12	39	4	16301321
Pubmed	Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families.	GNB4 GNB1 GNB2 GNB3	6.64e-10	12	39	4	8636150
Pubmed	Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.	RFX1 RFX2 RFX3	1.30e-09	3	39	3	15024578
Pubmed	Genomic organization of the murine G protein beta subunit genes and related processed pseudogenes.	GNB1 GNB2 GNB3	1.30e-09	3	39	3	11913780
Pubmed	Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.	RFX1 RFX2 RFX3	1.30e-09	3	39	3	12403718
Pubmed	RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.	RFX1 RFX2 RFX3	1.30e-09	3	39	3	8289803
Pubmed	Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.	RFX1 RFX2 RFX3	1.30e-09	3	39	3	10330134
Pubmed	Ciliogenic RFX transcription factors regulate FGF1 gene promoter.	RFX1 RFX2 RFX3	1.30e-09	3	39	3	22415835
Pubmed	Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.	RFX1 RFX2 RFX3	1.30e-09	3	39	3	32725242
Pubmed	Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta.	GNB4 GNB1 GNB2 GNB3	1.83e-09	15	39	4	12486123
Pubmed	Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity.	GNB4 GNB1 GNB2 GNB3	3.18e-09	17	39	4	19376773
Pubmed	Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.	RFX1 RFX2 RFX3	5.21e-09	4	39	3	11682486
Pubmed	Differential expression of Rfx1-4 during mouse spermatogenesis.	RFX1 RFX2 RFX3	5.21e-09	4	39	3	19596083
Pubmed	The cationic region of Rhes mediates its interactions with specific Gbeta subunits.	GNB1 GNB2 GNB3	5.21e-09	4	39	3	19255495
Pubmed	Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors.	GNB4 GNB1 GNB2	2.60e-08	6	39	3	16371464
Pubmed	G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development.	GNB4 GNB1 GNB2 GNB3	2.71e-08	28	39	4	8858601
Pubmed	Glucagon and regulation of glucose metabolism.	GNB4 GNB1 GNB2 GNB3	4.15e-08	31	39	4	12626323
Pubmed	Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium.	GNB4 GNB1 GNB3	4.55e-08	7	39	3	10570481
Pubmed	A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits.	GNB1 GNB2 GNB3	7.27e-08	8	39	3	9789084
Pubmed	Gβγ interacts with mTOR and promotes its activation.	GNB1 GNB2 GNB3	7.27e-08	8	39	3	24462769
Pubmed	Specificities of Gβγ subunits for the SNARE complex before and after stimulation of α2a-adrenergic receptors.	GNB4 GNB1 GNB2	2.14e-07	11	39	3	34932372
Pubmed	Human Multisubunit E3 Ubiquitin Ligase Required for Heterotrimeric G-Protein β-Subunit Ubiquitination and Downstream Signaling.	GNB4 GNB1 GNB2	2.85e-07	12	39	3	34342229
Pubmed	Gbeta3 forms distinct dimers with specific Ggamma subunits and preferentially activates the beta3 isoform of phospholipase C.	GNB1 GNB2 GNB3	4.70e-07	14	39	3	19168127
Pubmed	Different roles of G protein subunits beta1 and beta2 in neutrophil function revealed by gene expression silencing in primary mouse neutrophils.	GNB1 GNB2	1.23e-06	2	39	2	20525682
Pubmed	Chromosomal localization of the genes encoding two forms of the G protein beta polypeptide, beta 1 and beta 3, in man.	GNB1 GNB3	1.23e-06	2	39	2	1979057
Pubmed	RFX1 and RFX3 Transcription Factors Interact with the D Sequence of Adeno-Associated Virus Inverted Terminal Repeat and Regulate AAV Transduction.	RFX1 RFX3	1.23e-06	2	39	2	29317724
Pubmed	The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19.	RFX1 RFX2	1.23e-06	2	39	2	1505960
Pubmed	Proteolipid protein is required for transport of sirtuin 2 into CNS myelin.	NFASC GNB4 GNB1 GNB2 SDHA	1.29e-06	169	39	5	17634366
Pubmed	Rfx6 directs islet formation and insulin production in mice and humans.	RFX1 RFX2 RFX3	1.71e-06	21	39	3	20148032
Pubmed	The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis.	RFX1 RFX2 RFX3	1.98e-06	22	39	3	19887680
Pubmed	KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.	GNB4 GNB1 GNB2	2.60e-06	24	39	3	23209302
Pubmed	Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter.	RFX1 RFX3	3.67e-06	3	39	2	12411430
Pubmed	RFX transcription factors are essential for hearing in mice.	RFX1 RFX3	3.67e-06	3	39	2	26469318
Pubmed	Mutations in G protein β subunits promote transformation and kinase inhibitor resistance.	GNB1 GNB2	3.67e-06	3	39	2	25485910
Pubmed	G protein beta gamma subunits. Simplified purification and properties of novel isoforms.	GNB1 GNB2	3.67e-06	3	39	2	8308009
Pubmed	Selective association of G protein beta(4) with gamma(5) and gamma(12) subunits in bovine tissues.	GNB4 GNB2	3.67e-06	3	39	2	10409705
Pubmed	G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus.	GNB1 GNB2	7.34e-06	4	39	2	15955845
Pubmed	Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia.	GNB1 GNB3	7.34e-06	4	39	2	25093805
Pubmed	The RFX family interacts at the collagen (COL1A2) start site and represses transcription.	RFX1 RFX2	7.34e-06	4	39	2	11986307
Pubmed	G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells.	GNB4 GNB3	7.34e-06	4	39	2	12454992
Pubmed	Transcriptional regulation of the Alström syndrome gene ALMS1 by members of the RFX family and Sp1.	RFX1 RFX2	7.34e-06	4	39	2	20381594
Pubmed	Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.	EPB41L5 GNB4 GNB1 GNB2 DHX30	7.89e-06	245	39	5	21182205
Pubmed	Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq.	GNB4 GNB1	1.22e-05	5	39	2	11294873
Pubmed	Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor.	GNB1 GNB2	1.22e-05	5	39	2	7649993
Pubmed	Intersubunit surfaces in G protein alpha beta gamma heterotrimers. Analysis by cross-linking and mutagenesis of beta gamma.	GNB1 GNB3	1.22e-05	5	39	2	8550614
Pubmed	RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom.	RFX1 RFX3	1.22e-05	5	39	2	8600444
Pubmed	Localization of the gene for a third G protein beta-subunit to mouse chromosome 6 near Raf-1.	GNB1 GNB3	1.22e-05	5	39	2	1572642
Pubmed	Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning.	RFX1 RFX3	1.22e-05	5	39	2	24531968
Pubmed	The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety.	GNB4 GNB1 GNB2	1.56e-05	43	39	3	26487511
Pubmed	Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.	GNB1 GNB2	1.83e-05	6	39	2	9238069
Pubmed	Dynamic changes in cis-regulatory occupancy by Six1 and its cooperative interactions with distinct cofactors drive lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium.	RFX1 RFX2	1.83e-05	6	39	2	31956913
Pubmed	Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits.	GNB1 GNB2	1.83e-05	6	39	2	7665596
Pubmed	RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow.	RFX2 RFX3	2.56e-05	7	39	2	22233545
Pubmed	Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF.	EPB41L5 EPB41L4B	3.42e-05	8	39	2	22006950
Pubmed	Ataxin 10 induces neuritogenesis via interaction with G-protein beta2 subunit.	GNB1 GNB2	4.39e-05	9	39	2	16498633
Pubmed	Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins.	RFX1 RFX2	4.39e-05	9	39	2	8661125
Pubmed	Network organization of the huntingtin proteomic interactome in mammalian brain.	NFASC GNB4 GNB1 GNB2 GNB3 CARD14	6.25e-05	621	39	6	22794259
Pubmed	Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor-mediated chemotaxis.	GNB1 GNB2	6.70e-05	11	39	2	32332099
Pubmed	G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator.	RFX2 RFX3	6.70e-05	11	39	2	18218630
Pubmed	Developmental expression of heterotrimeric G-proteins in the murine cerebellar cortex.	GNB1 GNB2	6.70e-05	11	39	2	11685543
Pubmed	Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits.	GNB1 GNB2	8.03e-05	12	39	2	17110384
Pubmed	The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction.	GNB4 GNB1	9.48e-05	13	39	2	12782285
Pubmed	NRIP is newly identified as a Z-disc protein, activating calmodulin signaling for skeletal muscle contraction and regeneration.	DCAF6 SDHA	9.48e-05	13	39	2	26430214
Pubmed	Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice.	GNB4 GNB1 GNB3	1.21e-04	85	39	3	25131634
Pubmed	Interaction of G-protein βγ complex with chromatin modulates GPCR-dependent gene regulation.	GNB1 GNB2	1.27e-04	15	39	2	23326349
Pubmed	CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.	DOCK10 GNB2 SDHA RFWD3 DHX30	1.28e-04	440	39	5	35156780
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	GNB4 ATG2A GNB1 GNB2 ANAPC5 RFWD3 SNX17	1.38e-04	1038	39	7	26673895
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	NFASC GNB1 GNB2 GNB3 EPB41L4B MYO9A SDHA DHX30	1.59e-04	1431	39	8	37142655
Pubmed	Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis.	RFX2 RFX3	1.65e-04	17	39	2	31068677
Pubmed	A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131.	GNB1 GNB3	1.65e-04	17	39	2	24367558
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	ASPM EPB41L5 DIDO1 GNB2 RFX1	1.77e-04	472	39	5	38943005
Pubmed	Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.	GNB4 GNB1 GNB2 GNB3	1.93e-04	256	39	4	24189400
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	RFX3 SNX17 PKD1	1.96e-04	100	39	3	25807483
Pubmed	Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.	GNB4 GNB1 GNB2 GNB3	2.01e-04	259	39	4	9811942
Pubmed	High-throughput mapping of a dynamic signaling network in mammalian cells.	DCAF6 GNB2 GNB3 ANAPC5	2.04e-04	260	39	4	15761153
Pubmed	A Proteomic Variant Approach (ProVarA) for Personalized Medicine of Inherited and Somatic Disease.	GNB2 SDHA	2.07e-04	19	39	2	29924966
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	ASPM GNB4 DCAF6 GNB1 GNB2 ANAPC5 DHX30	2.65e-04	1155	39	7	20360068
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NFASC DIDO1 ATG2A FLYWCH1 SNX17	3.00e-04	529	39	5	14621295
Pubmed	Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human.	GNB1 GNB2	3.33e-04	24	39	2	2902634
Pubmed	Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.	EPOR DIDO1 RFWD3	3.43e-04	121	39	3	26354767
Pubmed	Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins.	GNB2 GNB3	3.62e-04	25	39	2	17185339
Pubmed	Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks.	DCAF6 GNB2 GNB3	3.86e-04	126	39	3	24319055
Pubmed	Integral and associated lysosomal membrane proteins.	GNB4 GNB1 GNB2	3.86e-04	126	39	3	17897319
Pubmed	Genetic link between renal birth defects and congenital heart disease.	SNX17 PKD1	4.55e-04	28	39	2	27002738
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	EPB41L5 DIDO1 GNB2 MYO9A ANAPC5 PKD1	5.37e-04	925	39	6	28986522
Pubmed	Purification and identification of G protein-coupled receptor protein complexes under native conditions.	GNB4 GNB1	5.58e-04	31	39	2	17215244
Pubmed	Role of Elavl-like RNA-binding protein in retinal development and signal transduction.	GNB1 GNB3	5.58e-04	31	39	2	39307290
Pubmed	Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development.	GNB1 GNB3	5.95e-04	32	39	2	19805139
Pubmed	The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route.	GNB1 GNB3	5.95e-04	32	39	2	23704327
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	EPB41L5 GNB1 GNB2 FLYWCH1 EPB41L4B DHX30	6.14e-04	949	39	6	36574265
Interaction	GNGT2 interactions	GNB4 GNB1 GNB2 GNB3	5.26e-09	12	38	4	int:GNGT2
Interaction	GNG11 interactions	GNB4 GNB1 GNB2 GNB3	2.51e-08	17	38	4	int:GNG11
Interaction	RGS6 interactions	GNB4 GNB1 GNB2 GNB3	3.23e-08	18	38	4	int:RGS6
Interaction	GNG7 interactions	GNB4 GNB1 GNB2 GNB3	5.09e-08	20	38	4	int:GNG7
Interaction	GNG3 interactions	GNB4 GNB1 GNB2 GNB3	1.11e-07	24	38	4	int:GNG3
Interaction	GNG4 interactions	GNB4 GNB1 GNB2 GNB3	1.32e-07	25	38	4	int:GNG4
Interaction	FOXJ1 interactions	ASPM RFX1 RFX2 RFX3	1.56e-07	26	38	4	int:FOXJ1
Interaction	GNGT1 interactions	GNB4 GNB1 GNB2 GNB3	1.56e-07	26	38	4	int:GNGT1
Interaction	RFX2 interactions	EPB41L5 RFX1 RFX2 RFX3	2.13e-07	28	38	4	int:RFX2
Interaction	GNAI1 interactions	EPOR GNB4 ABCA3 GNB1 GNB2 GNB3	7.53e-07	171	38	6	int:GNAI1
Interaction	GNG13 interactions	GNB4 GNB1 GNB2 GNB3	1.03e-06	41	38	4	int:GNG13
Interaction	GNG10 interactions	GNB4 GNB1 GNB2 GNB3	1.26e-06	43	38	4	int:GNG10
Interaction	PDCL interactions	GNB4 GNB1 KLHL33 GNB2 GNB3	4.89e-06	133	38	5	int:PDCL
Interaction	GNG2 interactions	GNB4 GNB1 GNB2 GNB3	1.07e-05	73	38	4	int:GNG2
Interaction	RASD2 interactions	GNB1 GNB2 GNB3	1.38e-05	25	38	3	int:RASD2
Interaction	GNG5 interactions	GNB4 GNB1 GNB2 GNB3	1.53e-05	80	38	4	int:GNG5
Interaction	RFX1 interactions	EPB41L5 RFX1 RFX2 RFX3	1.61e-05	81	38	4	int:RFX1
Interaction	GNG12 interactions	GNB4 GNB1 GNB2 GNB3	6.18e-05	114	38	4	int:GNG12
Interaction	RFX3 interactions	RFX1 RFX2 RFX3	8.31e-05	45	38	3	int:RFX3
Interaction	GNG8 interactions	GNB4 GNB1 GNB2 GNB3	8.84e-05	125	38	4	int:GNG8
Interaction	GNAQ interactions	GNB4 GNB1 GNB2 GNB3	1.19e-04	135	38	4	int:GNAQ
Interaction	FOXN3 interactions	RFX1 RFX2 RFX3	1.36e-04	53	38	3	int:FOXN3
Interaction	KCTD2 interactions	GNB4 GNB1 GNB2	1.52e-04	55	38	3	int:KCTD2
Interaction	RFX4 interactions	RFX2 RFX3	1.54e-04	10	38	2	int:RFX4
Interaction	CUL4A interactions	NLN GNB4 DCAF6 GNB1 GNB2 GNB3 ANAPC5 SDHA	1.59e-04	854	38	8	int:CUL4A
Interaction	GNAI2 interactions	GNB4 GNB1 GNB2 GNB3 DHX30	1.64e-04	277	38	5	int:GNAI2
Interaction	KLK3 interactions	EPOR DIDO1 DCAF6	1.97e-04	60	38	3	int:KLK3
Interaction	ECT2 interactions	ASPM EPB41L5 GNB4 GNB1 GNB2 GNB3 RFWD3 DHX30	2.06e-04	887	38	8	int:ECT2
Interaction	PPIA interactions	ASPM EPB41L5 DIDO1 NLN GNB2 RFX1 EPB41L4B SDHA	2.07e-04	888	38	8	int:PPIA
Interaction	INPP5K interactions	ASPM RFX1 RFX3	2.49e-04	65	38	3	int:INPP5K
Interaction	CDKL2 interactions	GNB1 GNB2 DHX30	3.24e-04	71	38	3	int:CDKL2
Interaction	PFDN1 interactions	DCAF6 GNB1 GNB2 RFWD3	3.51e-04	179	38	4	int:PFDN1
Interaction	SDHAF4 interactions	NLN SDHA	3.58e-04	15	38	2	int:SDHAF4
Interaction	CHMP4B interactions	GNB4 GNB1 GNB2 GNB3 ANAPC5 SDHA DHX30	3.67e-04	727	38	7	int:CHMP4B
Interaction	FOXJ2 interactions	RFX1 RFX2 RFX3	4.77e-04	81	38	3	int:FOXJ2
Interaction	FOXN2 interactions	RFX1 RFX2	5.20e-04	18	38	2	int:FOXN2
Interaction	PCSK1 interactions	DCAF6 SDHA	5.20e-04	18	38	2	int:PCSK1
Interaction	AK9 interactions	GNB2 MYO9A	5.80e-04	19	38	2	int:AK9
Interaction	CDC42 interactions	DOCK10 EPB41L5 GNB4 GNB1 EPB41L4B MYO9A SDHA SNX17 DHX30	6.33e-04	1323	38	9	int:CDC42
Interaction	DQX1 interactions	DCAF6 MYO9A	7.11e-04	21	38	2	int:DQX1
Interaction	KCNJ5 interactions	GNB4 GNB2	7.81e-04	22	38	2	int:KCNJ5
Interaction	GALK2 interactions	GNB4 GNB2	7.81e-04	22	38	2	int:GALK2
Interaction	KCTD5 interactions	GNB4 GNB1 GNB2	8.07e-04	97	38	3	int:KCTD5
Cytoband	16p13.3	ABCA3 FLYWCH1 PKD1	1.18e-03	244	39	3	16p13.3
Cytoband	12p13	GNB3 KLRC3	1.37e-03	64	39	2	12p13
Cytoband	3p21.31	CCDC51 DHX30	3.30e-03	100	39	2	3p21.31
Cytoband	Ensembl 112 genes in cytogenetic band chr16p13	ABCA3 FLYWCH1 PKD1	5.66e-03	426	39	3	chr16p13
GeneFamily	Regulatory factor X family	RFX1 RFX2 RFX3	3.38e-07	8	34	3	1153
GeneFamily	WD repeat domain containing	GNB4 DCAF6 GNB1 GNB2 GNB3 RFWD3	8.37e-06	262	34	6	362
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	KLRC3 PKD1	2.69e-03	41	34	2	1298
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	EPB41L5 EPB41L4B	3.97e-03	50	34	2	1293
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPB41L5 SCTR EPOR EPB41L4B	1.43e-05	169	39	4	2d23b4cee060f8adddc430c1c10d4e25205b4af6
ToppCell	356C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DIDO1 ABCA3 EPB41L4B RASSF2	1.43e-05	169	39	4	0425d2580ed325178f522c0093ff4623de6ce7a8
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPB41L5 SCTR EPOR EPB41L4B	1.43e-05	169	39	4	ecaf08e8e0b54d1c97a02bc1f65409fd43d68227
ToppCell	356C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DIDO1 ABCA3 EPB41L4B RASSF2	1.43e-05	169	39	4	fec669968a77060bd77ee8695034e35a642c984f
ToppCell	facs-Lung-Endomucin-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPB41L5 SCTR EPOR EPB41L4B	1.43e-05	169	39	4	ad6af6609acf158cb79e45ee7ca9af332be3c40c
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK10 DCAF6 MYO9A RASSF2	1.56e-05	173	39	4	869da6a65d1b9b7529c666ec44e3c8ddec2ea408
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK10 DCAF6 MYO9A RASSF2	1.56e-05	173	39	4	0672bd8a4a9d18af343d01f09253fb3388896c10
ToppCell	facs-Brain_Myeloid-Cerebellum-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK10 DCAF6 MYO9A RASSF2	1.56e-05	173	39	4	870e091ec30be01a900e1cb8b9ef1880e3b7b50d
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TSPEAR EPB41L5 ABCA3 MYO9A	2.12e-05	187	39	4	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK10 ENOSF1 RASSF2 KLRC3	2.30e-05	191	39	4	2110a1dd10730ad7ee7a265fb1716ab3ddafcf4a
ToppCell	(11)_FOXN4+\|World / shred by cell type by condition	ASPM RFX2 RFX3 RASSF2	2.65e-05	198	39	4	516b1acdf997dd8debc3dca066519366e507b414
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK10 NFASC RASSF2 SLC22A17	2.76e-05	200	39	4	56f1f007ba8c9188a4b10e52744f1e50dc0f155a
Computational	Neighborhood of MAP2K2	GNB1 GNB2 ANAPC5 SDHA	2.25e-04	132	25	4	MORF_MAP2K2
Drug	Barium	GNB4 GNB1 GNB2 GNB3	6.25e-06	72	38	4	ctd:D001464
Drug	Clomipramine hydrochloride [17321-77-6]; Up 200; 11.4uM; HL60; HG-U133A	EPOR DIDO1 GNB3 EPB41L4B CARD14	1.79e-05	196	38	5	1566_UP
Drug	Flavoxate hydrochloride [3717-88-2]; Up 200; 9.4uM; PC3; HT_HG-U133A	EPB41L5 EPOR ABCA3 ANAPC5 SLC22A17	1.88e-05	198	38	5	6326_UP
Disease	proteinuria (implicated_via_orthology)	EPB41L5 SORCS1	7.23e-04	30	39	2	DOID:576 (implicated_via_orthology)
Disease	Moyamoya disease	NLN CARD14	1.29e-03	40	39	2	MONDO_0016820
Disease	suicide behaviour measurement	TSPEAR RASSF2	1.49e-03	43	39	2	EFO_0006882
Disease	complement factor H-related protein 4 measurement	ASPM RFX2	1.92e-03	49	39	2	EFO_0600091

Protein segments in the cluster

Peptide	Gene	Start	Entry
MLRRGSQALRRFSTG	ALDH1L2	1	Q3SY69
RSRFLSGGMRRKLSI	ABCA3	661	Q99758
VRIYDRRMLGTRATG	DCAF6	216	Q58WW2
LRRALGRMVERSLRS	DHX30	1141	Q7L2E3
SFRGVRVRRTLRKMQ	ASPM	2176	Q8IZT6
LRTGSRGRRTTSMEV	ATG2A	501	Q2TAZ0
QFRGRRRSKSRTGMD	CCDC113	76	Q9H0I3
EPRMGRSRRAFLTGL	POLM	36	Q9NP87
MRTRSDVGVRRRGNV	RASSF2	141	P50749
VGPMRTRRRVSASRR	RFWD3	146	Q6PCD5
RTGEGAVSLMERRRL	ANAPC5	46	Q9UJX4
CVRFGRMSTRELRRV	KLHL33	161	A6NCF5
RMSTRELRRVRAAGL	KLHL33	166	A6NCF5
RGRAITRGLRATVMR	FLYWCH1	156	Q4VC44
RSRAITQGRRVTVMR	FLYWCH1	461	Q4VC44
MVRGRISRLSVRDVR	ENOSF1	1	Q7L5Y1
GRIQMRTRRTLRGHL	GNB2	41	P62879
GRVQMRTRRTLRGHL	GNB3	41	P16520
GRIQMRTRRTLRGHL	GNB4	41	Q9HAV0
SMRRRSGTLVIDFRS	NFASC	91	O94856
MLSFFRRTLGRRSMR	EPB41L5	1	Q9HCM4
GRLDVSESGVLMRRR	CARD14	546	Q9BXL6
MAGERTRRFTRSLLR	DOCK10	1	Q96BY6
GRIQMRTRRTLRGHL	GNB1	41	P62873
QFLTIARRRGRRSMP	DIDO1	76	Q9BTC0
RGRTRYTFAVRARMA	EPOR	211	P19235
MLRFLRRTFGRRSMQ	EPB41L4B	1	Q9H329
RRTFGRRSMQRYARG	EPB41L4B	6	Q9H329
SAGMRLVLRRGVLRD	PKD1	2426	P98161
RFGRRGILLLSMTLT	SLC22A17	361	Q8WUG5
MSGVRGLSRLLSARR	SDHA	1	P31040
VRRGLLGRDLFMTRT	CCDC51	21	Q96ER9
GKLIRSVFMGLRTRR	RFX1	481	P22670
SVFMGLRTRRLGTRG	RFX1	486	P22670
RSVFMGLRTRRLGTR	RFX2	246	P48378
GKLIRSIFMGLRTRR	RFX3	226	P48380
SIFMGLRTRRLGTRG	RFX3	231	P48380
GQRVGSRVGRFRSMI	PRSS47P	241	A8MTI9
GSSRIIRRGFIMLTR	KLRC3	221	Q07444
PRRKTQGFLTMSRRR	CNK3/IPCEF1	481	G9CGD6
SLRRVGGSRILLRMT	NLN	11	Q9BYT8
SIRKMLRRRVGGTLR	SNX17	391	Q15036
RFLRMLTSRNGSLFR	SCTR	91	P47872
GSRRRAKGLFMGLVR	TSPEAR	201	Q8WU66
GASMAVAARSGRRRR	SORCS1	96	Q8WY21
RLSLIRRSMGKGRIR	MYO9A	2271	B2RTY4