Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	-	RNF14 TRIM66 ARIH1 TRIM6 BRCA1 TRIM24 NSD3	5.77e-05	449	42	7	3.30.40.10
Domain	RING	RNF14 ARIH1 TRIM6 BRCA1 TRIM24 NSD3	5.77e-05	305	42	6	SM00184
Domain	Znf_RING/FYVE/PHD	RNF14 TRIM66 ARIH1 TRIM6 BRCA1 TRIM24 NSD3	6.63e-05	459	42	7	IPR013083
Domain	Znf_RING	RNF14 ARIH1 TRIM6 BRCA1 TRIM24 NSD3	8.34e-05	326	42	6	IPR001841
Domain	E3_UB_ligase_RBR	RNF14 ARIH1	2.20e-04	10	42	2	IPR031127
Domain	ADR_fam	ADRB3 HTR4	2.20e-04	10	42	2	IPR002233
Domain	Zinc_finger_PHD-type_CS	TRIM66 TRIM24 NSD3	4.19e-04	65	42	3	IPR019786
Domain	IBR	RNF14 ARIH1	4.42e-04	14	42	2	PF01485
Domain	IBR	RNF14 ARIH1	4.42e-04	14	42	2	SM00647
Domain	ZF_RING_1	RNF14 ARIH1 TRIM6 BRCA1 TRIM24	4.71e-04	291	42	5	PS00518
Domain	Znf_RING_CS	RNF14 TRIM6 BRCA1 TRIM24	4.83e-04	163	42	4	IPR017907
Domain	BBOX	TRIM66 TRIM6 TRIM24	5.00e-04	69	42	3	SM00336
Domain	Bbox_C	TRIM66 TRIM24	5.09e-04	15	42	2	IPR003649
Domain	IBR_dom	RNF14 ARIH1	5.09e-04	15	42	2	IPR002867
Domain	BBC	TRIM66 TRIM24	5.09e-04	15	42	2	SM00502
Domain	ZF_RING_2	RNF14 ARIH1 TRIM6 BRCA1 TRIM24	5.24e-04	298	42	5	PS50089
Domain	-	TRIM66 TRIM6 TRIM24	5.43e-04	71	42	3	4.10.45.10
Domain	zf-B_box	TRIM66 TRIM6 TRIM24	5.66e-04	72	42	3	PF00643
Domain	PHD	TRIM66 TRIM24 NSD3	6.38e-04	75	42	3	PF00628
Domain	Znf_PHD-finger	TRIM66 TRIM24 NSD3	7.42e-04	79	42	3	IPR019787
Domain	ZF_BBOX	TRIM66 TRIM6 TRIM24	7.70e-04	80	42	3	PS50119
Domain	Znf_B-box	TRIM66 TRIM6 TRIM24	7.99e-04	81	42	3	IPR000315
Domain	PHD	TRIM66 TRIM24 NSD3	1.05e-03	89	42	3	SM00249
Domain	Znf_PHD	TRIM66 TRIM24 NSD3	1.12e-03	91	42	3	IPR001965
Domain	PAS_fold_3	PER3 EPAS1	1.21e-03	23	42	2	IPR013655
Domain	PAS_3	PER3 EPAS1	1.21e-03	23	42	2	PF08447
Domain	ZF_PHD_2	TRIM66 TRIM24 NSD3	1.27e-03	95	42	3	PS50016
Domain	ZF_PHD_1	TRIM66 TRIM24 NSD3	1.31e-03	96	42	3	PS01359
Domain	PAS-assoc_C	PER3 EPAS1	1.32e-03	24	42	2	IPR000700
Domain	PAC	PER3 EPAS1	1.55e-03	26	42	2	SM00086
Domain	PAC	PER3 EPAS1	1.55e-03	26	42	2	PS50113
Domain	PAC	PER3 EPAS1	1.55e-03	26	42	2	IPR001610
Domain	zf-C3HC4	RNF14 TRIM6 BRCA1 TRIM24	1.55e-03	223	42	4	PF00097
Domain	PAS	PER3 EPAS1	2.35e-03	32	42	2	SM00091
Domain	PAS	PER3 EPAS1	2.65e-03	34	42	2	IPR000014
Domain	PAS	PER3 EPAS1	2.65e-03	34	42	2	PS50112
Domain	BROMODOMAIN_1	TRIM66 TRIM24	3.13e-03	37	42	2	PS00633
Domain	Bromodomain	TRIM66 TRIM24	3.30e-03	38	42	2	PF00439
Domain	BROMODOMAIN_2	TRIM66 TRIM24	3.83e-03	41	42	2	PS50014
Domain	BROMO	TRIM66 TRIM24	4.02e-03	42	42	2	SM00297
Domain	Bromodomain	TRIM66 TRIM24	4.02e-03	42	42	2	IPR001487
Domain	-	TRIM66 TRIM24	4.02e-03	42	42	2	1.20.920.10
Domain	Znf_FYVE_PHD	TRIM66 TRIM24 NSD3	4.38e-03	147	42	3	IPR011011
Domain	Acyl_CoA_acyltransferase	ATE1 KAT14	4.60e-03	45	42	2	IPR016181
Pubmed	The C-terminal proteolytic fragment of the breast cancer susceptibility type 1 protein (BRCA1) is degraded by the N-end rule pathway.	ATE1 BRCA1	1.56e-06	2	44	2	22262859
Pubmed	UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.	ARIH1 BRCA1	2.34e-05	6	44	2	21532592
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	RLF RNF14 KLF17 GTF3C1 BRCA1 EPAS1 NAIP	2.83e-05	709	44	7	22988430
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	RLF GTF3C1 BRCA1 NSD3	3.95e-05	150	44	4	28242625
Pubmed	Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms.	ARIH1 BRCA1	6.99e-05	10	44	2	27312108
Pubmed	N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis.	ATE1 BRCA1	6.99e-05	10	44	2	29507222
Pubmed	Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15.	PAN2 RNF14 BRCA1	7.11e-05	63	44	3	23105109
Pubmed	TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids.	TRIM66 TRIM24	1.21e-04	13	44	2	15322135
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	DCLRE1A BRCA1 TRIM24 KAT14	1.80e-04	222	44	4	37071664
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	DCLRE1A MMS22L TRMT1L GTF3C1 BRCA1	2.62e-04	453	44	5	29656893
Pubmed	Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.	RNF14 BRCA1 TRIM24	3.24e-04	105	44	3	22493164
Pubmed	Negative modulation of androgen receptor transcriptional activity by Daxx.	RNF14 BRCA1	3.56e-04	22	44	2	15572661
Pubmed	Human transcription factor protein interaction networks.	RLF LASP1 FBN2 TRMT1L GTF3C1 BRCA1 TRIM24 KAT14	3.77e-04	1429	44	8	35140242
Pubmed	A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.	RNF14 BRCA1 TRIM24	4.56e-04	118	44	3	19690564
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RLF PLEKHH1 PACS1 ABAT AMER1 ARIH1 GTF3C1 NAIP	4.96e-04	1489	44	8	28611215
Pubmed	Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.	GTF3C1 TRIM24 KAT14	5.39e-04	125	44	3	32891193
Pubmed	Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.	SPPL3 TRIM24	8.55e-04	34	44	2	19197348
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	RLF GTF3C1 BRCA1 TRIM24 NSD3	9.93e-04	608	44	5	36089195
Pubmed	Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse.	RLF EPAS1	1.07e-03	38	44	2	27930960
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	DCLRE1A PEF1 BRCA1 TRIM24	1.07e-03	357	44	4	37059091
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	TRMT1L ARIH1 GTF3C1 NSD3	1.22e-03	370	44	4	22922362
Pubmed	The tripartite motif family identifies cell compartments.	TRIM6 TRIM24	1.24e-03	41	44	2	11331580
Interaction	CBX1 interactions	RLF TRIM66 ATE1 GTF3C1 BRCA1 TRIM24 NSD3	1.99e-06	288	42	7	int:CBX1
Interaction	ASF1A interactions	PAN2 MMS22L GTF3C1 BRCA1 TRIM24 NSD3	1.21e-05	249	42	6	int:ASF1A
Interaction	CNN2 interactions	PAN2 ABAT ATE1 BRCA1	2.30e-05	80	42	4	int:CNN2
Cytoband	Ensembl 112 genes in cytogenetic band chr1p34	RLF KLF17 GRIK3	2.84e-03	294	44	3	chr1p34
Cytoband	Ensembl 112 genes in cytogenetic band chr8p11	ADRB3 NSD3	4.43e-03	103	44	2	chr8p11
GeneFamily	PHD finger proteins	TRIM66 TRIM24 NSD3	4.39e-04	90	30	3	88
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM66 TRIM6 TRIM24	5.15e-04	95	30	3	59
GeneFamily	Ring finger proteins	RNF14 TRIM6 BRCA1 TRIM24	1.05e-03	275	30	4	58
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#3_top-relative-expression-ranked_1000	RLF FLRT2 GPC6 TRIM24 NSD3	7.90e-05	225	42	5	gudmap_developingGonad_e14.5_ ovary_1000_k3
CoexpressionAtlas	DevelopingGonad_e16.5_ovary_emap-9563_k-means-cluster#2_top-relative-expression-ranked_1000	RLF AMER1 FLRT2 TRIM24 NSD3	8.76e-05	230	42	5	gudmap_developingGonad_e16.5_ovary_1000_k2
CoexpressionAtlas	DevelopingGonad_e14.5_ ovary_emap-6699_top-relative-expression-ranked_1000	RLF TRIM66 FLRT2 PER3 BRCA1 GPC6 TRIM24 NSD3	1.20e-04	776	42	8	gudmap_developingGonad_e14.5_ ovary_1000
CoexpressionAtlas	alpha beta T cells, T.8Eff.Sp.OT1.d6.LisOva, CD8+ CD45.1+, Spleen, avg-3	KLRK1 MMS22L BRCA1 TTC39C EPAS1 SIDT1	1.31e-04	402	42	6	GSM605898_500
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#3_top-relative-expression-ranked_1000	RLF AMER1 GPC6 TRIM24 NSD3	2.02e-04	275	42	5	gudmap_developingGonad_e14.5_ epididymis_1000_k3
CoexpressionAtlas	dev gonad_e11.5_F_GonadVasMes_Flk_k-means-cluster#4_top-relative-expression-ranked_500	AMER1 FLRT2 FBN2 GPC6	2.06e-04	148	42	4	gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_k4_500
CoexpressionAtlas	DevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#3_top-relative-expression-ranked_1000	AMER1 FLRT2 GPC6 TRIM24 NSD3	2.09e-04	277	42	5	gudmap_developingGonad_e12.5_ovary_k3_1000
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#5_top-relative-expression-ranked_500	RLF AMER1 FLRT2 TRIM24	2.17e-04	150	42	4	gudmap_developingGonad_e12.5_epididymis_k5_500
Computational	Fetal liver genes - metabolism and xenobiotics.	ABAT RNASE3 FBN2 HTR4 EPAS1 SLPI	4.84e-04	453	25	6	MODULE_24
Computational	Neighborhood of PSMF1	RNF14 BRCA1 SLC30A3 TRIM24	5.51e-04	167	25	4	MORF_PSMF1
Computational	Neighborhood of NF1	HTR4 BRCA1 SLC30A3 TRIM24	5.89e-04	170	25	4	MORF_NF1
Computational	Neighborhood of ESR1	HTR4 BRCA1 SLC30A3 TRIM24	6.16e-04	172	25	4	MORF_ESR1
Disease	cytokine measurement	PACS1 MMS22L FLRT2 FBN2 TRIM6 GPC6	6.01e-05	461	44	6	EFO_0004873
Disease	polycystic ovary syndrome (biomarker_via_orthology)	ADRB3 SLPI	4.48e-04	21	44	2	DOID:11612 (biomarker_via_orthology)
Disease	Mental Depression	GRIK3 PER3 HTR4 BRCA1	5.55e-04	254	44	4	C0011570
Disease	Depressive disorder	GRIK3 PER3 HTR4 BRCA1	8.99e-04	289	44	4	C0011581
Disease	neuroticism measurement, cognitive function measurement	MMS22L PEF1 GRIK3 GTF3C1 HTR4	1.49e-03	566	44	5	EFO_0007660, EFO_0008354
Disease	age at menarche	TRIM66 ATE1 HTR4 BRCA1 EPAS1	1.85e-03	594	44	5	EFO_0004703
Disease	vital capacity	PAN2 TRIM66 MMS22L FLRT2 ATE1 HTR4 TRIM24	2.19e-03	1236	44	7	EFO_0004312
Disease	amino acid measurement	SPPL3 ABAT FLRT2 PER3 EPAS1	3.27e-03	678	44	5	EFO_0005134
Disease	lifestyle measurement	PACS1 MMS22L HTR4	5.19e-03	235	44	3	EFO_0010724
Disease	response to bronchodilator, FEV/FEC ratio	RLF MMS22L GRIK3 FLRT2 GPC6	5.47e-03	766	44	5	EFO_0004713, GO_0097366
Disease	obesity	TRIM66 PACS1 FBN2	5.57e-03	241	44	3	EFO_0001073
Disease	alcoholic liver disease	SPPL3 FBN2	6.69e-03	82	44	2	EFO_0008573

Protein segments in the cluster

Peptide	Gene	Start	Entry
TRCFPNCPFLQNMKS	NAIP	336	Q13075
IYNPRNLQPQCIMCV	EPAS1	326	Q99814
NLQPQCIMCVNYVLS	EPAS1	331	Q99814
QSPYRQATCCIPPMT	AMER1	986	Q5JTC6
SNPRCCAFASNMPYV	ADRB3	191	P13945
IPNNMRYCNSSVPDL	FLRT2	641	O43155
MPVQAVCPYCGNRII	LITAFD	1	A0A1B0GVX0
NTRSSAQDMPCQICY	ARIH1	176	Q9Y4X5
LSCPQRPQMFLASCQ	MUC6	751	Q6W4X9
PHIPNAYCNCMIQVL	PAN2	521	Q504Q3
YLQGMCIVCCQSQNP	MMS22L	1001	Q6ZRQ5
TCMINQAPGCPDYSI	ABAT	196	P80404
MNPNCARCGKIVYPT	LASP1	1	Q14847
PDQMRRNTCPQTEYC	PER3	941	P56645
ENCSTPNTYICMQRT	KLRK1	201	P26718
CYVRPNHIPTINSMC	KAT14	641	Q9H8E8
NPPRCTIAMRAINNY	RNASE3	46	P12724
VSRYCPRSANPAMQL	PEF1	226	Q9UBV8
QRYCNCNSSMPRPVK	PACS1	611	Q6VY07
ICCYGPFTNMPTDQL	BRCA1	1766	P38398
PTVRPCNNYCLNVMK	GPC6	261	Q9Y625
AICCQPLVYRNKMTP	HTR4	121	Q13639
VMNQTCCPQYTIRCR	ATE1	66	O95260
CPQATLTPSRMIYCQ	KLF17	101	Q5JT82
CQSALYMPVPCQPST	KRTAP29-1	216	A8MX34
YCPNCQMPFSSLIGQ	DCLRE1A	121	Q6PJP8
YRTGPCFTQVNNQMC	FBN2	211	P35556
NILSCCKNMTRFQPP	DEFB136	56	Q30KP8
CYQRAPQMTVNSLQC	GRIK3	336	Q13003
CSNLTPNVPNVCRMY	SPACA3	151	Q8IXA5
PNVPNVCRMYCSDLL	SPACA3	156	Q8IXA5
VVPYCSNNMPPICVQ	CFAP47	1716	Q6ZTR5
NMVEENPYRQLPCNC	TRMT1L	501	Q7Z2T5
VTYGQCLMLNPPNFC	SLPI	91	P03973
VVYCPRPCCQLPVMQ	RNF14	306	Q9UBS8
SFCQRCLPAPQRYLM	TRIM24	76	O15164
QQAYITCLCSMLPNE	RLF	251	Q13129
PMCQYLTRPCSPQNK	SPPL3	116	Q8TCT6
PCSVVSVQNIMCPVY	SIDT1	211	Q9NXL6
SCVQVNLPPSMCDYR	GAFA1	51	Q96PS6
EIYCQLMKQTSCRPP	PLEKHH1	896	Q9ULM0
NRMLQYECHPQVCPA	NSD3	1116	Q9BZ95
QYQPEMAQCLRCQEP	SLC30A3	371	Q99726
CQMTYIKSPAPCQTQ	XP32	116	Q5T750
PNCSFPNLQRMSQAC	TTC39C	461	Q8N584
NSCQMKFQLRCTPVP	GTF3C1	1671	Q12789
CENACYNQPGMRASP	TRIM66	1026	O15016
YFNPCNCVIPMTLRR	TRIM6	471	Q9C030