Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	BAT2_N	PRRC2C PRRC2B	1.48e-05	3	42	2	IPR009738
Domain	BAT2_N	PRRC2C PRRC2B	1.48e-05	3	42	2	PF07001
Domain	PRRC2	PRRC2C PRRC2B	1.48e-05	3	42	2	IPR033184
Domain	Homeobox_metazoa	NKX2-3 NKX2-5 NKX1-2	1.08e-03	90	42	3	IPR020479
Domain	TUDOR	PHF1 PHF20L1	1.67e-03	27	42	2	SM00333
Domain	Tudor	PHF1 PHF20L1	2.06e-03	30	42	2	IPR002999
Domain	Homeobox_CS	NKX2-3 NKX2-5 NKX1-2	8.39e-03	186	42	3	IPR017970
Domain	Zinc_finger_PHD-type_CS	PHF1 PHF20L1	9.39e-03	65	42	2	IPR019786
Domain	Homeobox	NKX2-3 NKX2-5 NKX1-2	1.56e-02	234	42	3	PF00046
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	ZC3H18 EIF3A SAFB SRSF5 PRRC2C PRRC2B	7.92e-06	361	46	6	26167880
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	ZC3H18 EIF3A SAFB SERBP1 SRSF5 WDR33 PRRC2C PRRC2B	9.71e-06	807	46	8	22681889
Pubmed	Xnkx-2.1: a homeobox gene expressed during early forebrain, lung and thyroid development in Xenopus laevis.	NKX2-3 NKX2-5	1.03e-05	4	46	2	11180810
Pubmed	Overexpression of WNK1 in POMC-expressing neurons reduces weigh gain via WNK4-mediated degradation of Kir6.2.	WNK4 KCNJ11	1.03e-05	4	46	2	29392534
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	EIF3A SAFB SERBP1 SRSF5 WDR33 PRRC2C PRRC2B	1.54e-05	615	46	7	31048545
Pubmed	NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis.	NKX2-3 NKX2-5	1.71e-05	5	46	2	12141427
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	EIF3A SERBP1 SRSF5 PRRC2C PRRC2B	2.31e-05	258	46	5	37794589
Pubmed	Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors.	NKX2-5 NKX1-2	2.56e-05	6	46	2	9748262
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	EIF3A SAFB SERBP1 SRSF5 WDR33 PRRC2C PRRC2B	3.55e-05	701	46	7	30196744
Pubmed	Phenotypic characterization of the murine Nkx2.6 homeobox gene by gene targeting.	NKX2-3 NKX2-5	3.58e-05	7	46	2	10733590
Pubmed	NKX2 gene expression in neuroectoderm but not in mesendodermally derived structures depends on sonic hedgehog in mouse embryos.	NKX2-3 NKX2-5	3.58e-05	7	46	2	10603087
Pubmed	Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels.	KCNJ11 TRPC5	4.77e-05	8	46	2	25471572
Pubmed	Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain.	FOXD2 NKX2-3 NKX2-5	6.03e-05	57	46	3	21122108
Pubmed	Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: a candidate gene for skeletal dysplasia.	NKX2-3 NKX2-5	6.12e-05	9	46	2	9344671
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	ZC3H18 SAFB SERBP1 SRSF5 DHX37	7.43e-05	330	46	5	33301849
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	ZC3H18 EIF3A SAFB SERBP1 SRSF5 PRRC2C	1.40e-04	605	46	6	28977666
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	ZC3H18 EIF3A SAFB PRRC2C	1.49e-04	202	46	4	24639526
Pubmed	The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.	SAFB SERBP1 SRSF5 PRRC2C	1.52e-04	203	46	4	35012549
Pubmed	O-linked β-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1.	REC8 NKX2-5	1.54e-04	14	46	2	32251422
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ZC3H18 SERBP1 SRSF5 DHX37 PRRC2C PRRC2B	2.12e-04	653	46	6	22586326
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	REC8 GJC2 FBXO11 ZC3H18 SAFB SERBP1 SRSF5 SOWAHB	3.15e-04	1327	46	8	32694731
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	ZC3H18 SAFB SERBP1 SRSF5 WDR33 PRRC2C	3.39e-04	713	46	6	29802200
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	ZC3H18 SAFB SERBP1 PRRC2C	3.41e-04	251	46	4	31076518
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	ZC3H18 SAFB WDR33 PRRC2B	3.41e-04	251	46	4	28077445
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	FBXO11 SRSF5 PRRC2C WNK4 PRRC2B	3.54e-04	462	46	5	31138677
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	ZC3H18 EIF3A SAFB SRSF5 WDR33 PRRC2C	3.87e-04	731	46	6	29298432
Pubmed	PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA.	PRRC2C PRRC2B	3.89e-04	22	46	2	38507412
Pubmed	Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation.	EIF3A SAFB SERBP1 PRRC2B	4.42e-04	269	46	4	30442662
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	EIF3A SERBP1 SRSF5 DHX37 PRRC2C	4.46e-04	486	46	5	30940648
Pubmed	Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.	FBXO11 EIF3A SAFB PRRC2B	4.55e-04	271	46	4	25737280
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	NKX2-5 ZC3H18 EIF3A DHX37 PRRC2B COQ8B	4.56e-04	754	46	6	33060197
Pubmed	Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.	SAFB SERBP1 SRSF5	4.70e-04	114	46	3	31553912
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	FBXO11 ZC3H18 SAFB SRSF5 CATSPERG WDR33 DHX37	5.13e-04	1082	46	7	38697112
Pubmed	Inhibition of UBE2D3 expression attenuates radiosensitivity of MCF-7 human breast cancer cells by increasing hTERT expression and activity.	SERBP1 PHF20L1	5.45e-04	26	46	2	23741361
Pubmed	Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis.	NUTM1 NKX2-5	5.45e-04	26	46	2	23892084
Pubmed	Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.	ZC3H18 KATNAL1 PHF20L1	5.59e-04	121	46	3	26354767
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	DIAPH2 MARVELD3 KIFC2 SOWAHB PIEZO1 PRRC2B KCNJ11	5.81e-04	1105	46	7	35748872
Pubmed	Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP.	SAFB SERBP1	7.27e-04	30	46	2	22963397
Pubmed	The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development.	NKX2-5 KCNJ11	7.27e-04	30	46	2	39366945
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	EIF3A SAFB SERBP1 PRRC2C PRRC2B	7.86e-04	551	46	5	34728620
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	ZC3H18 EIF3A SAFB SERBP1 SRSF5 DHX37	8.37e-04	847	46	6	35850772
Pubmed	Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia.	EIF3A SRSF5 PRRC2C	1.12e-03	154	46	3	36490346
Pubmed	The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development.	NKX2-5 COQ8B	1.17e-03	38	46	2	33913477
GeneFamily	NKL subclass homeoboxes and pseudogenes	NKX2-3 NKX2-5 NKX1-2	2.03e-04	67	31	3	519
GeneFamily	Tudor domain containing	PHF1 PHF20L1	1.83e-03	37	31	2	780
GeneFamily	PHD finger proteins	PHF1 PHF20L1	1.04e-02	90	31	2	88
Disease	prediabetes syndrome (biomarker_via_orthology)	SIRT3 KCNJ11	1.36e-04	12	43	2	DOID:11716 (biomarker_via_orthology)
Disease	HETE measurement	HMGN2P46 PIEZO1	3.71e-03	62	43	2	EFO_0801166

Protein segments in the cluster

Peptide	Gene	Start	Entry
RQERYRARPPRVLER	CATSPERG	656	Q6ZRH7
GAAFRDRRKRIPRNP	DIAPH2	1066	O60879
DRRKRIPRNPDNRRV	DIAPH2	1071	O60879
PPRRRRRRRLLFWDK	REC8	296	O95072
RRPERRPPRERRFEK	SERBP1	126	Q8NC51
PRKEERPRAAREPRE	JSRP1	261	Q96MG2
RPRAAREPREALPQR	JSRP1	266	Q96MG2
SEQERRRALRRRPGP	GJC2	106	Q5T442
PERPLQRRERRYLQR	HMGN2P46	111	Q86SG4
PAKPRYRARQRRARF	KCNJ11	21	Q14654
LAERPRRARRDPRAG	PAPPA	21	Q13219
ARRTRRARPRAKEPP	H1-7	186	Q75WM6
ERPRARRRRKPRVLF	NKX2-5	131	P52952
TRAPRRRQRKAQRPP	NUTM1	341	Q86Y26
AGRPRAERRPRRVEA	FAM189A2	421	Q15884
TEPRRRPPLKDQRER	CCDC107	46	Q8WV48
RRDLRDDRDRRGPPL	EIF3A	1286	Q14152
AANRRPRRVSRPRPV	FBXO11	6	Q86XK2
RAREARPRKTPRPQL	COQ8B	61	Q96D53
HDRPRDRPGDPRRKR	MARVELD3	31	Q96A59
RKPRYVRRERPLDRA	C1orf159	351	Q96HA4
CRRLRKAFPPSRARP	DHX37	486	Q8IY37
ERPKPRSRRKPRVLF	NKX2-3	141	Q8TAU0
PAQRARKPRGRRRPD	KIFC2	31	Q96AC6
FQNKRARLPPAERRR	CPHXL	76	A0A1W2PPM1
RRRDSAAKEPPAPRR	REM1	246	O75628
NPPRPFKHSERRRRS	PHF20L1	401	A8MW92
GKRRRPEPEPLRRRQ	PHF1	366	O43189
FLRRRKRFKRQPLPP	FOXD2	216	O60548
RSRRRRPRREALFFP	PLD6	31	Q8N2A8
PQIRRPNREVRPLRK	KATNAL1	111	Q9BW62
PRRRRLEPNCAKPRR	NKX1-2	151	Q9UD57
RKFDPARERPRRQRP	PRRC2C	1411	Q9Y520
QDKPPRFRRLREREA	PRRC2C	1431	Q9Y520
PRPEVPRAFRRQPRA	SIRT3	71	Q9NTG7
DPYRREPRSPRKSRQ	STXBP5	676	Q5T5C0
PQQQPRRRRREKEPE	SOWAHB	116	A6NEL2
SRRPRNDRRNAPPVR	SRSF5	91	Q13243
RRPAVRRPYDLDRRD	SAFB	706	Q15424
FPRERKRFRGQERPD	AKAP3	261	O75969
QREAPLRRPPQRRAR	ADGRD2	101	Q7Z7M1
PEDARRRPEARRPRG	ATG4D	16	Q86TL0
ARPEDCPRAKPRRRV	PRRC2B	1116	Q5JSZ5
SENAENRPFRRRRPP	PRRC2B	1291	Q5JSZ5
NRPFRRRRPPRQDKP	PRRC2B	1296	Q5JSZ5
RRRPPRQDKPPRFRR	PRRC2B	1301	Q5JSZ5
RQDKPPRFRRLRQER	PRRC2B	1306	Q5JSZ5
RPRRREAAPRGREAA	SRRD	26	Q9UH36
ARRGRPPTRRRQFRD	ZNF213	296	O14771
FCPKRDPDGRRRRRN	TRPC5	681	Q9UL62
RRPVRPKRAEPREAS	PIEZO1	396	Q92508
RFPRDPEDPRFRGRR	WDR33	1086	Q9C0J8
RRARRFSGKAEPRPR	WNK4	41	Q96J92
REARRKERPARTPPR	ZC3H18	666	Q86VM9