Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	stem cell population maintenance	MMP24 PIWIL2 PRAMEF18 NODAL PRAMEF19	8.04e-05	237	39	5	GO:0019827
GeneOntologyBiologicalProcess	maintenance of cell number	MMP24 PIWIL2 PRAMEF18 NODAL PRAMEF19	8.87e-05	242	39	5	GO:0098727
Domain	PRAME_family	PRAMEF18 PRAMEF19	7.47e-04	19	40	2	IPR026271
Domain	Pentatricopeptide_repeat	POLRMT DENND4A	1.10e-03	23	40	2	IPR002885
Domain	PTB	SHC2 TNS3	3.31e-03	40	40	2	SM00462
Domain	PTB/PI_dom	SHC2 TNS3	3.48e-03	41	40	2	IPR006020
Domain	Ig_I-set	HMCN2 MYPN MYOM3	7.77e-03	190	40	3	IPR013098
Domain	I-set	HMCN2 MYPN MYOM3	7.77e-03	190	40	3	PF07679
Domain	Zinc_finger_PHD-type_CS	JADE2 RSF1	8.54e-03	65	40	2	IPR019786
Pubmed	The expansion of the PRAME gene family in Eutheria.	PRAMEF18 PRAMEF19	3.87e-06	3	40	2	21347312
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	EFHC2 DGLUCY PRAMEF18 PRAMEF19 MYPN HLA-G MYOM3	1.06e-05	674	40	7	37196079
Pubmed	Duplication and positive selection among hominin-specific PRAME genes.	PRAMEF18 PRAMEF19	1.29e-05	5	40	2	16159394
Pubmed	An abundance of X-linked genes expressed in spermatogonia.	PIWIL2 PRAMEF18 PRAMEF19	4.38e-05	59	40	3	11279525
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF18 PRAMEF19	1.73e-04	17	40	2	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF18 PRAMEF19	1.73e-04	17	40	2	37781892
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF18 PRAMEF19	1.95e-04	18	40	2	29731491
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF18 PRAMEF19	1.95e-04	18	40	2	23894331
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF18 PRAMEF19	1.95e-04	18	40	2	14675769
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF18 PRAMEF19	1.95e-04	18	40	2	12890732
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF18 PRAMEF19	1.95e-04	18	40	2	39181896
Pubmed	Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.	JARID2 LTK ZNF184 HOMEZ	1.97e-04	251	40	4	29031500
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF18 PRAMEF19	2.18e-04	19	40	2	28604677
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF18 PRAMEF19	2.42e-04	20	40	2	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF18 PRAMEF19	2.42e-04	20	40	2	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF18 PRAMEF19	2.42e-04	20	40	2	21425410
Pubmed	KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation.	JADE2 RSF1	2.67e-04	21	40	2	27270040
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF18 PRAMEF19	2.94e-04	22	40	2	31729367
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF18 PRAMEF19	3.21e-04	23	40	2	19480014
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF18 PRAMEF19	3.80e-04	25	40	2	37451217
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF18 PRAMEF19	3.80e-04	25	40	2	12620990
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF18 PRAMEF19	4.12e-04	26	40	2	18500982
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF18 PRAMEF19	4.78e-04	28	40	2	25089626
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	THEMIS2 JARID2 PRAMEF18 PRAMEF19 ZNF184 HOMEZ HLA-G	4.83e-04	1242	40	7	30973865
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF18 PRAMEF19	5.50e-04	30	40	2	38786026
Pubmed	LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.	PRAMEF18 PRAMEF19	6.26e-04	32	40	2	37889087
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF18 PRAMEF19	7.49e-04	35	40	2	19389355
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	DHX15 DGLUCY JADE2 HLA-G	8.60e-04	371	40	4	15747579
Cytoband	1p36.21	PRAMEF18 PRAMEF19	1.40e-03	63	40	2	1p36.21
GeneFamily	PRAME family	PRAMEF18 PRAMEF19	6.25e-04	24	28	2	686
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	HMCN2 MYPN MYOM3	1.93e-03	161	28	3	593
GeneFamily	PHD finger proteins	JADE2 RSF1	8.52e-03	90	28	2	88
GeneFamily	SH2 domain containing	SHC2 TNS3	1.06e-02	101	28	2	741
Disease	coffee consumption measurement	DHX15 AUTS2 JADE2 HYDIN MYPN	3.14e-06	182	37	5	EFO_0006781
Disease	Drugs used in diabetes use measurement	AUTS2 SCTR LTK JADE2	2.88e-04	255	37	4	EFO_0009924
Disease	bipolar disorder	AUTS2 JADE2 SVEP1 ZNF184 MYOM3	7.30e-04	577	37	5	MONDO_0004985
Disease	pulse pressure measurement	DHX15 SSPOP HYDIN SVEP1 TNS3 MYPN HOMEZ	1.52e-03	1392	37	7	EFO_0005763
Disease	open-angle glaucoma	EFHC2 SVEP1 HLA-G	1.76e-03	191	37	3	EFO_0004190
Disease	complement C4 measurement	ZNF184 HLA-G	1.95e-03	52	37	2	EFO_0004984
Disease	Diabetes Mellitus, Non-Insulin-Dependent	AUTS2 SCTR JADE2	2.67e-03	221	37	3	C0011860
Disease	neutrophil count, basophil count	THEMIS2 UBR2 TNS3	2.77e-03	224	37	3	EFO_0004833, EFO_0005090
Disease	aspartate aminotransferase to alanine aminotransferase ratio	DHX15 AUTS2 JARID2	3.33e-03	239	37	3	EFO_0010934
Disease	vital capacity	AUTS2 PIWIL2 JADE2 SVEP1 MYPN ZNF184	4.07e-03	1236	37	6	EFO_0004312

Protein segments in the cluster

Peptide	Gene	Start	Entry
VPRVCAKPWAPDMTL	CDCA5	191	Q96FF9
CRAKQMGLEPPPEVW	POLD4	71	Q9HCU8
PQWCVEYMRSLPGPK	DHX15	171	O43143
PLFCLPMGATIECWP	DENND4A	231	Q7Z401
FPWRVTMPGEPVDVA	RCC1L	436	Q96I51
CPRMEPRAPWVEQEG	HLA-G	66	P17693
IEWMKKPRCGVPDHP	MMP24	131	Q9Y5R2
WEMPRPVVCDPLCTF	GLIPR1L2	241	Q4G1C9
LCEAMGIPPPAIRWF	HMCN2	2381	Q8NDA2
WIPEVSIGCPEKMEP	JADE2	281	Q9NQC1
PVKWMPPEAFLEGIF	LTK	686	P29376
ERCEDVWLGMPSPIP	EFHC2	716	Q5JST6
VLKVMVQAWPFPCLP	PRAMEF18	51	Q5VWM3
TDPFRPMLRKPGKWC	AUTS2	636	Q8WXX7
PGRVMVWPAVRPGIC	POU5F2	41	Q8N7G0
GPARWKMQLFEQPCP	FAAP100	146	Q0VG06
VCPMEGWIPPLSRFP	HYDIN	4136	Q4G0P3
MVRGWEPPPGLDCAI	HOMEZ	1	Q8IX15
GDAMVCPPGEVPVFW	DGLUCY	211	Q7Z3D6
IREWKRTGCFPVPMV	COLGALT2	221	Q8IYK4
LRPPLMIIPDGEWFC	RSF1	921	Q96T23
FEAVDVPMLCPPLPW	POLRMT	641	O00411
VEKFGMCRVIPPPDW	JARID2	581	Q92833
MCRVIPPPDWRPECK	JARID2	586	Q92833
PPPDWRPECKLNDEM	JARID2	591	Q92833
PVPGMCPRDKQWLDC	SSPOP	3086	A2VEC9
KQMSRVAGECWPRPP	NODAL	171	Q96S42
AVRMPGCWPQASKPL	PIWIL2	21	Q8TC59
VLKVMVQAWPFPCLP	PRAMEF19	51	Q5SWL8
VGWPELHAPPLDKMC	TNS3	71	Q68CZ2
KWVPPEGQDMPRCIA	SVEP1	2066	Q4LDE5
IYLPPPWGTCKAVTM	ASIC1	281	P78348
GMVCRKPTDPVDWPP	WASHC5	1061	Q12768
CALLPRMPQWKFAAP	SHC2	26	P98077
DSEPGMCFEIPPRWL	THEMIS2	491	Q5TEJ8
WPSSVPGRMVEVECP	SCTR	76	P47872
QMPKEEFPPSPECWR	HEATR9	46	A2RTY3
PNEEDPRVPIMCWGS	UBR2	1321	Q8IWV8
CTWMFKPQPVDRPVG	XIRP1	626	Q702N8
PWIMEPSIPVGTCAD	ZNF184	86	Q99676
LFECKEWTMPQPGPP	MYOM3	791	Q5VTT5
LECRVIGMPPPVFYW	MYPN	1191	Q86TC9