Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	actin filament binding	MYO3A SYNE1 MACF1 MYO18B MYO15A PLS1	2.12e-04	227	75	6	GO:0051015
GeneOntologyMolecularFunction	alpha-glucosidase activity	MGAM GANAB	2.89e-04	7	75	2	GO:0090599
GeneOntologyBiologicalProcess	negative regulation of mitochondrial DNA metabolic process	LIG3 ATG7	1.34e-05	2	76	2	GO:1901859
GeneOntologyBiologicalProcess	negative regulation of mitochondrial DNA replication	LIG3 ATG7	1.34e-05	2	76	2	GO:0090298
Domain	Glyco_hydro_31_CS	MGAM GANAB	9.75e-05	4	76	2	IPR030459
Domain	Actinin_actin-bd_CS	SYNE1 MACF1 PLS1	1.08e-04	23	76	3	IPR001589
Domain	ACTININ_2	SYNE1 MACF1 PLS1	1.08e-04	23	76	3	PS00020
Domain	ACTININ_1	SYNE1 MACF1 PLS1	1.08e-04	23	76	3	PS00019
Domain	GLYCOSYL_HYDROL_F31_2	MGAM GANAB	1.62e-04	5	76	2	PS00707
Domain	Glyco_hydro_31_AS	MGAM GANAB	2.43e-04	6	76	2	IPR030458
Domain	PDZ	MAST4 STXBP4 RAPGEF2 ARHGAP21 PDZD2	2.74e-04	141	76	5	PF00595
Domain	Glyco_hydro_31	MGAM GANAB	3.39e-04	7	76	2	IPR000322
Domain	Desmosomal_cadherin	DSC1 DSC3	3.39e-04	7	76	2	IPR009122
Domain	Glyco_hydro_31	MGAM GANAB	3.39e-04	7	76	2	PF01055
Domain	Cadherin_pro	DSC1 DSC3	3.39e-04	7	76	2	PF08758
Domain	GLYCOSYL_HYDROL_F31_1	MGAM GANAB	3.39e-04	7	76	2	PS00129
Domain	PDZ	MAST4 STXBP4 RAPGEF2 ARHGAP21 PDZD2	3.43e-04	148	76	5	SM00228
Domain	-	MAST4 STXBP4 RAPGEF2 ARHGAP21 PDZD2	3.65e-04	150	76	5	2.30.42.10
Domain	PDZ	MAST4 STXBP4 RAPGEF2 ARHGAP21 PDZD2	3.76e-04	151	76	5	PS50106
Domain	PDZ	MAST4 STXBP4 RAPGEF2 ARHGAP21 PDZD2	3.88e-04	152	76	5	IPR001478
Domain	Cadherin_pro_dom	DSC1 DSC3	4.50e-04	8	76	2	IPR014868
Domain	Cadherin_pro	DSC1 DSC3	4.50e-04	8	76	2	SM01055
Domain	Myosin_head_motor_dom	MYO3A MYO18B MYO15A	4.93e-04	38	76	3	IPR001609
Domain	MYOSIN_MOTOR	MYO3A MYO18B MYO15A	4.93e-04	38	76	3	PS51456
Domain	Myosin_head	MYO3A MYO18B MYO15A	4.93e-04	38	76	3	PF00063
Domain	MYSc	MYO3A MYO18B MYO15A	4.93e-04	38	76	3	SM00242
Domain	Clathrin/coatomer_adapt-like_N	AP4E1 AP3B2	1.66e-03	15	76	2	IPR002553
Domain	Adaptin_N	AP4E1 AP3B2	1.66e-03	15	76	2	PF01602
Domain	Gal_mutarotase_SF_dom	MGAM GANAB	2.14e-03	17	76	2	IPR011013
Domain	CH	SYNE1 MACF1 PLS1	2.36e-03	65	76	3	SM00033
Domain	CH	SYNE1 MACF1 PLS1	2.91e-03	70	76	3	PF00307
Domain	IQ	MYO3A MYO18B MYO15A	3.03e-03	71	76	3	PF00612
Domain	-	SYNE1 MACF1 PLS1	3.03e-03	71	76	3	1.10.418.10
Domain	CH	SYNE1 MACF1 PLS1	3.28e-03	73	76	3	PS50021
Domain	CH-domain	SYNE1 MACF1 PLS1	3.54e-03	75	76	3	IPR001715
Domain	BRCT	LIG3 TP53BP1	3.58e-03	22	76	2	SM00292
Domain	Spectrin	SYNE1 MACF1	3.91e-03	23	76	2	PF00435
Domain	-	LIG3 TP53BP1	3.91e-03	23	76	2	3.40.50.10190
Domain	IQ	MYO3A MYO18B MYO15A	4.40e-03	81	76	3	SM00015
Domain	Cadherin_cytoplasmic-dom	DSC1 DSC3	4.61e-03	25	76	2	IPR000233
Domain	Cadherin_C	DSC1 DSC3	4.61e-03	25	76	2	PF01049
Domain	BRCT	LIG3 TP53BP1	4.99e-03	26	76	2	PS50172
Domain	BRCT_dom	LIG3 TP53BP1	5.77e-03	28	76	2	IPR001357
Domain	IQ_motif_EF-hand-BS	MYO3A MYO18B MYO15A	5.90e-03	90	76	3	IPR000048
Domain	Catenin_binding_dom	DSC1 DSC3	6.18e-03	29	76	2	IPR027397
Domain	Spectrin_repeat	SYNE1 MACF1	6.18e-03	29	76	2	IPR002017
Domain	-	DSC1 DSC3	6.18e-03	29	76	2	4.10.900.10
Domain	IQ	MYO3A MYO18B MYO15A	6.46e-03	93	76	3	PS50096
Domain	RA	GRB14 RAPGEF2	7.04e-03	31	76	2	SM00314
Domain	Spectrin/alpha-actinin	SYNE1 MACF1	7.49e-03	32	76	2	IPR018159
Domain	SPEC	SYNE1 MACF1	7.49e-03	32	76	2	SM00150
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	MYCBP2 SGCD SYNE1 ZBTB40 SRP68 MACF1 RABGEF1 MYO18B ARHGAP21	1.76e-06	497	78	9	23414517
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	LENG8 AP4E1 MACF1 CRYBG3 HNRNPA2B1 ARHGAP21 VPS13B	2.18e-06	263	78	7	34702444
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KDM5B MTMR4 MAST4 MYCBP2 STXBP4 MACF1 RABGEF1 CRYBG3 RAPGEF2 CDC25B ARHGAP21	3.45e-06	861	78	11	36931259
Pubmed	Patterns of desmocollin synthesis in human epithelia: immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells.	DSC1 DSC3	4.97e-06	2	78	2	8884173
Pubmed	The desmocollins of human foreskin epidermis: identification and chromosomal assignment of a third gene and expression patterns of the three isoforms.	DSC1 DSC3	4.97e-06	2	78	2	7665906
Pubmed	Genomic organization and amplification of the human desmosomal cadherin genes DSC1 and DSC3, encoding desmocollin types 1 and 3.	DSC1 DSC3	4.97e-06	2	78	2	11027496
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	VAPB MYBBP1A GANAB DSC3 MYCBP2 SYNE1 STXBP4 GLS MACF1 CRYBG3 HNRNPA2B1 TBL3 VPS13B TP53BP1	5.05e-06	1487	78	14	33957083
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	LIG3 MYBBP1A MYCBP2 GLE1 RNPC3 SRP68 MACF1 ZC3H7B HNRNPA2B1 TBL3	7.63e-06	759	78	10	35915203
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	LIG3 MYBBP1A SETD1B DSC1 DSC3 MYCBP2 GLS SRP68 MACF1 HNRNPA2B1 PHIP TBL3 TP53BP1	9.25e-06	1353	78	13	29467282
Pubmed	Whole exome sequencing reveals pathogenic variants in MYO3A, MYO15A and COL9A3 and differential frequencies in ancestral alleles in hearing impairment genes among individuals from Cameroon.	MYO3A MYO15A	1.49e-05	3	78	2	33078831
Pubmed	The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics.	MYCBP2 MAP3K12	1.49e-05	3	78	2	18031680
Pubmed	Desmocollin switching in colorectal cancer.	DSC1 DSC3	1.49e-05	3	78	2	17088906
Pubmed	Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps.	LIG3 TP53BP1	1.49e-05	3	78	2	34555355
Pubmed	SNP-specific array-based allele-specific expression analysis.	OSBPL1A NLRP2	1.49e-05	3	78	2	18369178
Pubmed	The influence of desmocollin 1-3 expression on prognosis after curative resection of colorectal liver metastases.	DSC1 DSC3	1.49e-05	3	78	2	23975055
Pubmed	Compositionally different desmosomes in the various compartments of the human hair follicle.	DSC1 DSC3	1.49e-05	3	78	2	9810708
Pubmed	Changing pattern of desmocollin 3 expression accompanies epidermal organisation during skin development.	DSC1 DSC3	1.49e-05	3	78	2	9389456
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ZSWIM8 MYBBP1A GANAB MYCBP2 SRP68 MACF1 PHIP TBL3 TP53BP1	1.58e-05	653	78	9	22586326
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	S100A11 MYO3A GANAB DSC1 DSC3 SYNE1 GLS SRP68 MACF1 HNRNPA2B1	1.91e-05	844	78	10	25963833
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZSWIM8 KDM5B MYCBP2 LONRF1 SYNE1 GLS OSBPL1A MACF1 RIPK4 RAPGEF2 QTRT1 ARHGAP21	2.81e-05	1285	78	12	35914814
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	VAPB MYBBP1A GANAB DSC3 SRP68 MACF1 CRYBG3 HNRNPA2B1 ARHGAP21	2.98e-05	708	78	9	39231216
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	GANAB SETD1B SYNE1 MACF1 ARHGAP21 VPS13B PDZD2	3.69e-05	407	78	7	12693553
Pubmed	Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.	ZSWIM8 MTMR4 STXBP4 GLS TP53BP1	3.82e-05	167	78	5	25659891
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	GREB1L KDM5B SATB2 MYCBP2 GLS CRYBG3 ARHGAP21	4.37e-05	418	78	7	34709266
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	VAPB LENG8 LIG3 MYBBP1A DSC1 STXBP4 SRP68 MACF1 ARHGAP21 TP53BP1	4.49e-05	934	78	10	33916271
Pubmed	Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma.	DSC1 DSC3	4.94e-05	5	78	2	22438068
Pubmed	Satb2 is required for dendritic arborization and soma spacing in mouse cerebral cortex.	SATB2 ATG7	4.94e-05	5	78	2	21885532
Pubmed	Nomenclature of the desmosomal cadherins.	DSC1 DSC3	4.94e-05	5	78	2	8486729
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	ZSWIM8 ARNT SETD1B STXBP4 MACF1 CRYBG3 TP53BP1 CDC7	5.28e-05	588	78	8	38580884
Pubmed	A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.	AP4E1 SATB2 ARNT SETD1B GLS CPLANE1 PHIP	5.30e-05	431	78	7	33660365
Pubmed	DNA Damage Regulates Translation through β-TRCP Targeting of CReP.	RIPK4 RAPGEF2 CDC25B	6.74e-05	35	78	3	26091241
Pubmed	BRCA1 safeguards genome integrity by activating chromosome asynapsis checkpoint to eliminate recombination-defective oocytes.	HORMAD1 TP53BP1	7.40e-05	6	78	2	38696471
Pubmed	The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons.	MYCBP2 MAP3K12	7.40e-05	6	78	2	17901218
Pubmed	Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse.	DSC1 DSC3	7.40e-05	6	78	2	9404003
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	VAPB LIG3 MYBBP1A GANAB DSC1 SYNE1 GLS SRP68 MYO18B HNRNPA2B1 PHIP TBL3	7.60e-05	1425	78	12	30948266
Pubmed	ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.	LENG8 S100A11 MYBBP1A DSC1 MYCBP2 RABGEF1 TBL3 CDC7	7.99e-05	624	78	8	33729478
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	VAPB S100A11 MYBBP1A GANAB MYCBP2 SYNE1 MACF1 MYO15A HNRNPA2B1	8.14e-05	807	78	9	30575818
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	VAPB TYMS DSC3 MACF1 CRYBG3 ARHGAP21 TP53BP1	9.34e-05	472	78	7	38943005
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	LIG3 MYBBP1A GANAB MYCBP2 GLE1 SYNE1 MACF1 HNRNPA2B1 PHIP TBL3	9.63e-05	1024	78	10	24711643
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	CABLES2 ZSWIM8 MYBBP1A SETD1B RAPGEF2 PHIP TP53BP1	9.72e-05	475	78	7	31040226
Pubmed	JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis.	MYCBP2 MAP3K12	1.04e-04	7	78	2	23979718
Pubmed	The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains.	MYCBP2 MAP3K12	1.04e-04	7	78	2	22798074
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	VAPB MYBBP1A AP3B2 MACF1 HNRNPA2B1 PHIP ARHGAP21	1.30e-04	498	78	7	36634849
Pubmed	A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.	LENG8 MYCBP2 GLE1	1.35e-04	44	78	3	26471122
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	LENG8 LIG3 MYBBP1A SATB2 PHIP TBL3	1.37e-04	349	78	6	25665578
Pubmed	Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites.	VAPB OSBPL1A	1.38e-04	8	78	2	29858488
Pubmed	TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.	LIG3 DSC1 DSC3 PLS1	1.43e-04	117	78	4	36898370
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	LIG3 KDM5B MYBBP1A GANAB MYCBP2 RNPC3 SYNE1 SRP68 MACF1 HNRNPA2B1	1.51e-04	1082	78	10	38697112
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	SETD1B HORMAD1 TP53BP1 CDC7	1.53e-04	119	78	4	23508102
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	MYBBP1A INTS13 PRAMEF14 STXBP4 ZBTB40 MACF1 CPLANE1 ARHGAP21 VPS13B TP53BP1	1.53e-04	1084	78	10	11544199
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	LENG8 S100A11 SATB2 ARNT MYCBP2 TOGARAM2 ZBTB40 SRP68 HNRNPA2B1 TP53BP1	1.76e-04	1103	78	10	34189442
Pubmed	Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.	MYO3A MYO15A	1.77e-04	9	78	2	19339464
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	LIG3 MYBBP1A SATB2 GANAB INTS13 PHIP TBL3	1.97e-04	533	78	7	30554943
Pubmed	Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype.	DSC1 DSC3	2.21e-04	10	78	2	12724416
Pubmed	Control of G2 Phase Duration by CDC25B Modulates the Switch from Direct to Indirect Neurogenesis in the Neocortex.	SATB2 CDC25B	2.21e-04	10	78	2	36596698
Pubmed	FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts.	VAPB OSBPL1A	2.70e-04	11	78	2	33124732
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	S100A11 FBXL13 PRAMEF14 MYO15A CPLANE1 HNRNPA2B1 CDC7	2.78e-04	564	78	7	21565611
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	TYMS LIG3 PLB1 DSC1 SYNE1 SRP68 HNRNPA2B1 ARHGAP21	2.90e-04	754	78	8	35906200
Pubmed	BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein.	GREB1L CABLES2 TOP6BL	2.91e-04	57	78	3	27433848
Pubmed	Defining desmosomal plakophilin-3 interactions.	DSC1 DSC3	3.23e-04	12	78	2	12707304
Pubmed	Functional proteomics mapping of a human signaling pathway.	ARNT MTMR4 MAST4 MYCBP2 RNPC3 MACF1 RABGEF1	3.68e-04	591	78	7	15231748
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	LENG8 S100A11 MYBBP1A DSC1 SGCD GLS HNRNPA2B1 TBL3 TP53BP1	3.69e-04	989	78	9	36424410
Pubmed	A physical map of the mouse shaker-2 region contains many of the genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2).	RNF112 MYO15A	3.81e-04	13	78	2	10049592
Pubmed	Assessment of splice variant-specific functions of desmocollin 1 in the skin.	DSC1 DSC3	3.81e-04	13	78	2	14673151
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	FBXL13 SYNE1 MACF1 PLS1	3.89e-04	152	78	4	34299191
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	VAPB GANAB DSC3 MYCBP2 GLE1 STXBP4 GLS RABGEF1 VPS51	4.21e-04	1007	78	9	34597346
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	LIG3 MYBBP1A SATB2 DSC1 SRP68 HNRNPA2B1 TBL3	4.23e-04	605	78	7	28977666
Pubmed	Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.	MYO3A MYO15A	4.44e-04	14	78	2	26754646
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	AP4E1 DSC3 AP3B2 RABGEF1 VPS51	4.62e-04	285	78	5	34369648
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	LENG8 MYBBP1A SETD1B MYCBP2 TBL3 TP53BP1	4.72e-04	440	78	6	34244565
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	VAPB MYBBP1A GANAB MYCBP2 SYNE1 GLS CRYBG3 HNRNPA2B1 PHIP TBL3 VPS13B	4.95e-04	1496	78	11	32877691
Pubmed	Desmosomal localization of beta-catenin in the skin of plakoglobin null-mutant mice.	DSC1 DSC3	5.12e-04	15	78	2	9847250
Pubmed	p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome.	DSC1 DSC3	5.12e-04	15	78	2	23108156
Pubmed	High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis.	DSC1 DSC3	5.12e-04	15	78	2	16170054
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	GANAB CRYBG3 TP53BP1	5.56e-04	71	78	3	33541421
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	VAPB MYBBP1A MTMR4 GANAB DSC3 MYCBP2 STXBP4 CRYBG3 CDC25B	5.65e-04	1049	78	9	27880917
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	LIG3 SATB2 INTS13 GLS SRP68 HORMAD1 TBL3	5.80e-04	638	78	7	31182584
Pubmed	Desmocollin 3 is required for pre-implantation development of the mouse embryo.	DSC1 DSC3	5.84e-04	16	78	2	16418220
Pubmed	IRF6 and AP2A Interaction Regulates Epidermal Development.	DSC1 DSC3	5.84e-04	16	78	2	29913133
Pubmed	RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis.	DSC1 DSC3	5.84e-04	16	78	2	30689641
Pubmed	SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis.	SATB2 TP53BP1	5.84e-04	16	78	2	33200984
Pubmed	SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response.	VAPB MYBBP1A GANAB SYNE1 HNRNPA2B1 TBL3	6.16e-04	463	78	6	34901782
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	VAPB S100A11 MTMR4 GANAB MYCBP2 GLS SRP68 MACF1 TBL3 TP53BP1	6.32e-04	1297	78	10	33545068
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	VAPB LENG8 AP4E1 GANAB MAST4 STXBP4 CPLANE1 ARHGAP21	6.54e-04	853	78	8	28718761
Pubmed	Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.	MYCBP2 MAP3K12	6.61e-04	17	78	2	19398581
Pubmed	Engagement of the G3BP2-TRIM25 Interaction by Nucleocapsid Protein Suppresses the Type I Interferon Response in SARS-CoV-2-Infected Cells.	AP4E1 LIG3 DSC1	6.78e-04	76	78	3	36560452
Pubmed	Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.	VAPB LIG3 ZBTB40 TP53BP1	7.04e-04	178	78	4	27637333
Pubmed	Probing nuclear pore complex architecture with proximity-dependent biotinylation.	GLE1 SYNE1 PDZD2	7.04e-04	77	78	3	24927568
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	VAPB MYBBP1A MYCBP2 OSBPL1A SRP68 RABGEF1 CDC25B VPS51 TP53BP1 CDC7	7.28e-04	1321	78	10	27173435
Pubmed	Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment.	ARNT HORMAD1	7.42e-04	18	78	2	23585552
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	TYMS GANAB DSC1 ATG7 GLS SRP68 QTRT1 HNRNPA2B1	7.89e-04	878	78	8	37223481
Pubmed	A human MAP kinase interactome.	LENG8 USF3 SYNE1 MACF1 RAPGEF2 CPLANE1	7.93e-04	486	78	6	20936779
Pubmed	Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.	ARNT TBL3	8.28e-04	19	78	2	17392787
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	MYBBP1A GANAB SRP68 HNRNPA2B1 TBL3 TP53BP1	8.63e-04	494	78	6	26831064
Pubmed	A comprehensive resource of interacting protein regions for refining human transcription factor networks.	ATG7 INTS13 ARHGAP21 TP53BP1	9.16e-04	191	78	4	20195357
Pubmed	Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF).	MYBBP1A INTS13 SRP68 HNRNPA2B1	9.16e-04	191	78	4	21907836
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	GLE1 SYNE1 SRP68 PHIP TBL3	9.18e-04	332	78	5	25693804
Pubmed	The RepID-CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation.	SATB2 PHIP	9.19e-04	20	78	2	31911655
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	SYNE1 MACF1	9.19e-04	20	78	2	21689717
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	MYBBP1A HNRNPA2B1 PHIP	9.71e-04	86	78	3	37253089
Cytoband	2p23.2	PLB1 TOGARAM2	2.20e-04	13	78	2	2p23.2
GeneFamily	PDZ domain containing	MAST4 STXBP4 RAPGEF2 ARHGAP21 PDZD2	8.15e-05	152	53	5	1220
GeneFamily	Desmosomal cadherins	DSC1 DSC3	1.75e-04	7	53	2	1188
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	USF3 SYNE1 TOGARAM2 MACF1 GRIK4 CPLANE1	6.92e-07	177	78	6	d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	USF3 SYNE1 TOGARAM2 MACF1 GRIK4 CPLANE1	6.92e-07	177	78	6	f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCell	COVID-19_Mild-Lymphoid_T/NK-NK_activated\|COVID-19_Mild / Disease group, lineage and cell class	USF3 SYNE1 TOGARAM2 MACF1 GRIK4 CPLANE1	6.92e-07	177	78	6	6978a22fef40c8b455342373abe7593f5ede0fa4
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	USF3 SYNE1 TOGARAM2 MACF1 GRIK4 CPLANE1	6.92e-07	177	78	6	936ab2b180a052387124f68d0c7f41c0b164e748
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	USF3 SYNE1 TOGARAM2 MACF1 GRIK4 CPLANE1	6.92e-07	177	78	6	d5aeda113afaa2425874394610344570c9078478
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	KDM5B USF3 GANAB CRYBG3 CPLANE1 VPS13B	1.15e-06	193	78	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	tumor_Lung-T/NK_cells-Cytotoxic_CD8+_T\|T/NK_cells / Location, Cell class and cell subclass	SATB2 SGCD SYNE1 CDC25B HORMAD1	1.03e-05	164	78	5	60fe6bb86afaebd92590135f08f5434ce0d8d73c
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM ZSWIM8 LONRF1 MYO18B RAPGEF2	1.41e-05	175	78	5	c1c722db42da9b8a2a46e516ddb83d9be5e2e504
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GREB1L SGCD GLS TOP6BL MYO18B	1.75e-05	183	78	5	b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	GREB1L MAST4 SGCD MYO18B PDZD2	1.80e-05	184	78	5	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	GREB1L MAST4 SGCD MYO18B PDZD2	1.84e-05	185	78	5	6baccb26f999145e51b91d94315bf8d4655bef31
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SATB2 MAST4 EDAR PLS1 PDZD2	1.89e-05	186	78	5	b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	GLS MACF1 RAPGEF2 HNRNPA2B1 TP53BP1	1.99e-05	188	78	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	GREB1L MAST4 SGCD MYO18B PDZD2	2.15e-05	191	78	5	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 MACF1 RAPGEF2 VPS13B PDZD2	2.20e-05	192	78	5	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GREB1L S100A11 SGCD GLS TOP6BL	2.32e-05	194	78	5	4d6c9b016e3a0641954a8ea10c97d1cd76fadd9f
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	GREB1L MAST4 SGCD MYO18B PDZD2	2.32e-05	194	78	5	c3535f7cc0076653c72db582047cff053c322397
ToppCell	IPF-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	SGCD MACF1 GRIK4 LTBP2 VPS13B	2.49e-05	197	78	5	f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RNPC3 SYNE1 GLS MACF1 VPS13B	2.61e-05	199	78	5	f0b0097df0026496470a80d8cc9375ffd8389b00
Disease	arrhythmogenic right ventricular cardiomyopathy (implicated_via_orthology)	DSC1 DSC3	6.34e-05	5	75	2	DOID:0050431 (implicated_via_orthology)
Disease	desmocollin-2 measurement	DSC1 DSC3	6.34e-05	5	75	2	EFO_0021936
Disease	cathepsin S measurement	ARNT HORMAD1	1.77e-04	8	75	2	EFO_0008073
Disease	Colorectal Carcinoma	TYMS LIG3 SATB2 ARNT INTS13 SYNE1 CCDC62 PHIP	4.09e-04	702	75	8	C0009402
Disease	Amyotrophic Lateral Sclerosis	VAPB GLE1 HNRNPA2B1	4.40e-04	58	75	3	C0002736
Disease	muscular dystrophy (is_implicated_in)	SGCD SYNE1	8.46e-04	17	75	2	DOID:9884 (is_implicated_in)
Disease	mean corpuscular hemoglobin concentration	TYMS SETD1B INTS13 STXBP4 GRB14 MACF1 MYO15A ARHGAP21 VPS13B	1.92e-03	1105	75	9	EFO_0004528
Disease	hair morphology	S100A11 EDAR	2.48e-03	29	75	2	EFO_0005038

Protein segments in the cluster

Peptide	Gene	Start	Entry
ELSDMVPTCSALARK	ARNT	111	P27540
KALDSSRDMCLSDLE	CCDC62	321	Q6P9F0
ADSMPVLACERSESR	CRYBG3	2031	Q68DQ2
REMHLEDTTRFCPKE	ARHGEF33	781	A8MVX0
RREDVLEECMSLPKL	GLE1	31	Q53GS7
TEKLMLPDTCRSDHI	AP3B2	996	Q13367
ELMKSLLPVDRSCED	AP4E1	601	Q9UPM8
PCLLMELRRDSSESQ	C18orf25	56	Q96B23
RRSSIEAMEESDRPC	OPALIN	56	Q96PE5
IEMDSKRVPRDKLAC	RABGEF1	276	Q9UJ41
TGLRTSDPRLKECMD	GLS	166	O94925
CLMACRSKPPEEEER	INTS13	556	Q9NVM9
KEPRESRTLEDMLCF	MYO15A	3036	Q9UKN7
INSTEMPAREDCLKR	LONRF1	396	Q17RB8
MPAREDCLKRVSSEP	LONRF1	401	Q17RB8
ESRDRGLSSKTLCME	MGAM	1451	O43451
SRKKMAALECEDPER	LENG8	491	Q96PV6
TELPFDCLEKTSRML	EDAR	346	Q9UNE0
CEEEEAMTPRPTKAR	HMGN2P46	41	Q86SG4
CKMINLSEPDTIDER	PLS1	166	Q14651
RALSMPDLDKLCSED	PDZD2	2486	O15018
CLSPDRKMEVEELSP	CDC25B	236	P30305
ACLDPSSLTLDDMRR	KDM5B	926	Q9UGL1
RMSPDIKQELLRCDI	NLRP2	576	Q9NX02
CSEESERPAKRLKMG	MIER3	471	Q7Z3K6
NDVSLMDRPLCERRK	LIG3	601	P49916
KDMESVIPKTDCRLR	OSBPL1A	861	Q9BXW6
ITSPLLRCDETFEKM	GREB1L	876	Q9C091
DCKAKMSELRVTLDP	MACF1	4926	Q9UPN3
KTLSMREVRSCFEDP	MYBBP1A	1036	Q9BQG0
PKTRSMDDLLSACDT	MTMR4	606	Q9NYA4
ECMDPKRLAESSVDL	ATG7	321	O95352
CATDRDEPDTMHTRL	DSC3	266	Q14574
RDDVLCSSMKEGRLE	CPLANE1	531	Q9H799
LCERLRGMDSSTPKL	CDC7	461	O00311
RLSDASVMKLSERCP	FBXL13	491	Q8NEE6
MRKLDPDTSDCTPEK	MAP3K12	26	Q12852
GLMLDPSRSRCVSDK	LTBP2	651	Q14767
ICLPRKEAESFMRTD	MASP2	551	O00187
SAARADTCREPSMEL	MAST4	1986	O15021
SECRMKDKSTRDVRP	DSC1	671	Q08554
PRDLKMLCAEEEQSR	GRB14	316	Q14449
EPSLVCEEDEIMRSK	HORMAD1	291	Q86X24
CEEDEIMRSKESPDL	HORMAD1	296	Q86X24
LDDPMECSRGERLSI	GRIK4	31	Q16099
KDTLSVRMLDDTRDP	GRIK4	186	Q16099
KREMRSLSEECSLEP	CABLES2	366	Q9BTV7
VLMEKEPQDTLCTRS	MROH5	456	Q6ZUA9
LRMTKLCDPAESELS	TAS2R39	16	P59534
DADLRATCLEEMTKR	QTRT1	206	Q9BXR0
EVDEKPRTLMTDCLV	TOP6BL	111	Q8N6T0
EECRTELDRETKLMP	SYNE1	1036	Q8NF91
EEEMDLRACKELRPF	TOGARAM2	471	Q6ZUX3
PETMSKRQTAEDCPR	PRAMEF14	126	Q5SWL7
VRRSSECMKDDPITL	GANAB	816	Q14697
MERRSESPCLRDSPD	SATB2	1	Q9UPW6
RERDRDMADTPCELA	SETD1B	996	Q9UPS6
LTKMEEEFRSPVRCI	MYCBP2	4206	O75592
MAKISSPTETERCIE	S100A11	1	P31949
KTETLDLRAEMPITC	PLB1	1026	Q6P1J6
LLPCDSSEADEMERL	STXBP4	286	Q6ZWJ1
KCSPSLHVDDRERME	RIPK4	51	P57078
ETKERLFESMLSECR	SRP68	331	Q9UHB9
LTKSPAVIMDEDCRS	C12orf40	236	Q86WS4
LMSRDIVRDCLEKDP	RAPGEF2	101	Q9Y4G8
KLRRECPLAQLMDSE	VPS51	76	Q9UID3
RPLLMESEEEDESCR	nan	61	Q6ZSR9
SDEMPSECISRRELE	RNPC3	381	Q96LT9
MSCERKGLSELRSEL	PHIP	1	Q8WWQ0
KLTDCVVMRDPASKR	HNRNPA2B1	46	P22626
AMSPELSRETRIKLC	RNF112	251	Q9ULX5
MEATCRTELRLESKD	SGCD	216	Q92629
RDPEACEKLEATMLR	TBL3	691	Q12788
DTIKTNPDDRRIIMC	TYMS	166	P04818
SIEATMERPLEKPSC	USF3	1201	Q68DE3
CLRMKLVSPETEASE	TP53BP1	986	Q12888
CESLLESRPSMGRKL	MYO18B	2351	Q8IUG5
PSEMSTMRCRAEELR	ZSWIM8	896	A7E2V4
NISESCRSPEERMKE	VPS13B	1041	Q7Z7G8
PEDLMDSKLRCVFEL	VAPB	111	O95292
ERLEDSVLMKYCPRS	ARHGAP21	461	Q5T5U3
ETKTCPLDLLMEEIR	ZBTB40	541	Q9NUA8
AKARKDMLLCPRDDD	ZC3H7B	931	Q9UGR2
EPRMSPDTCATILEK	MYO3A	1011	Q8NEV4