Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	peptide lactyltransferase (CoA-dependent) activity	CREBBP EP300	6.40e-06	2	51	2	GO:0120300
GeneOntologyMolecularFunction	histone H3K27 acetyltransferase activity	CREBBP EP300	6.40e-06	2	51	2	GO:0044017
GeneOntologyMolecularFunction	histone H3K18 acetyltransferase activity	CREBBP EP300	1.92e-05	3	51	2	GO:0043993
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR2 RYR3	3.82e-05	4	51	2	GO:0005219
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR2 RYR3	9.53e-05	6	51	2	GO:0048763
GeneOntologyMolecularFunction	histone H3 acetyltransferase activity	CREBBP EP300	6.57e-04	15	51	2	GO:0010484
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR2 RYR3	9.53e-04	18	51	2	GO:0015278
GeneOntologyMolecularFunction	transcription coactivator activity	MTA2 MAML2 ARID1A CREBBP EP300	1.03e-03	303	51	5	GO:0003713
GeneOntologyMolecularFunction	peroxisome proliferator activated receptor binding	CREBBP EP300	1.30e-03	21	51	2	GO:0042975
GeneOntologyMolecularFunction	extracellular matrix structural constituent	COL4A3 ENAM HMCN2 LAMA2	1.35e-03	188	51	4	GO:0005201
GeneOntologyMolecularFunction	nucleosome binding	MTA2 MLLT10 ARID1A	2.01e-03	98	51	3	GO:0031491
GeneOntologyMolecularFunction	chromatin binding	MTA2 ANKRD17 MLLT10 ARID1A CREBBP EP300 CUX1	2.59e-03	739	51	7	GO:0003682
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	RYR2 RYR3	2.84e-03	31	51	2	GO:0099604
GeneOntologyMolecularFunction	transcription coregulator activity	MTA2 DDX54 MAML2 ARID1A CREBBP EP300	2.98e-03	562	51	6	GO:0003712
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	RYR2 RYR3	3.21e-03	33	51	2	GO:0005217
GeneOntologyMolecularFunction	bHLH transcription factor binding	CREBBP EP300	4.02e-03	37	51	2	GO:0043425
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	MTA2 DDX54 ARID1A CREBBP EP300	4.14e-03	417	51	5	GO:0061629
GeneOntologyCellularComponent	external encapsulating structure	COL4A3 ENAM IGFALS HMCN2 OTOGL GPC4 LAMA2 EGFLAM PKHD1L1	3.15e-05	658	52	9	GO:0030312
GeneOntologyCellularComponent	sarcoplasmic reticulum membrane	SYNE2 RYR2 RYR3	1.91e-04	45	52	3	GO:0033017
GeneOntologyCellularComponent	extracellular matrix	COL4A3 ENAM IGFALS HMCN2 OTOGL GPC4 LAMA2 EGFLAM	2.00e-04	656	52	8	GO:0031012
GeneOntologyCellularComponent	basement membrane	COL4A3 HMCN2 LAMA2 EGFLAM	2.41e-04	122	52	4	GO:0005604
GeneOntologyCellularComponent	chromatin	MTA2 ONECUT2 BPTF SP2 CUX2 ANKRD17 SIX4 ARID1A CREBBP EP300 CUX1	8.76e-04	1480	52	11	GO:0000785
GeneOntologyCellularComponent	sarcolemma	LAMA2 ITGA7 RYR2 RYR3	1.27e-03	190	52	4	GO:0042383
GeneOntologyCellularComponent	sarcoplasmic reticulum	SYNE2 RYR2 RYR3	1.37e-03	88	52	3	GO:0016529
GeneOntologyCellularComponent	SWI/SNF superfamily-type complex	MTA2 BPTF ARID1A	1.76e-03	96	52	3	GO:0070603
HumanPheno	Plantar crease between first and second toes	CREBBP EP300	2.51e-05	2	26	2	HP:0008107
HumanPheno	Aortic isthmus hypoplasia	CREBBP EP300	2.51e-05	2	26	2	HP:0034227
HumanPheno	High axial triradius	CREBBP EP300	2.51e-05	2	26	2	HP:0001042
HumanPheno	Nasogastric tube feeding in infancy	PUF60 ITGA7 CREBBP EP300	3.14e-05	37	26	4	HP:0011470
HumanPheno	Broad hallux	BPTF PUF60 GPC4 CREBBP EP300	3.33e-05	76	26	5	HP:0010055
HumanPheno	Hypoplastic aortic arch	PUF60 CREBBP EP300	4.14e-05	14	26	3	HP:0012304
HumanPheno	Square face	PUF60 CREBBP EP300	6.33e-05	16	26	3	HP:0000321
HumanPheno	Broad toe	BPTF PUF60 GPC4 CREBBP EP300	6.42e-05	87	26	5	HP:0001837
HumanPheno	Laryngeal cartilage malformation	CREBBP EP300	7.49e-05	3	26	2	HP:0008752
HumanPheno	Phobia	CREBBP EP300	7.49e-05	3	26	2	HP:5200232
HumanPheno	Agoraphobia	CREBBP EP300	7.49e-05	3	26	2	HP:0000756
HumanPheno	Humoral immunodeficiency	CREBBP EP300	7.49e-05	3	26	2	HP:0005363
HumanPheno	Prominent nasal septum	CREBBP EP300	7.49e-05	3	26	2	HP:0005322
HumanPheno	Radial deviation of thumb terminal phalanx	CREBBP EP300	7.49e-05	3	26	2	HP:0005895
HumanPheno	Broad thumb	BPTF PUF60 GPC4 CREBBP EP300	7.56e-05	90	26	5	HP:0011304
HumanPheno	Pectus excavatum	PUF60 SYNE2 GPC4 ITGA7 PUM1 CREBBP EP300 CUX1	1.36e-04	323	26	8	HP:0000767
HumanPheno	Trichiasis	CREBBP EP300	1.49e-04	4	26	2	HP:0001128
HumanPheno	Visceral hemangioma	CREBBP EP300	1.49e-04	4	26	2	HP:0410266
HumanPheno	Talon cusp	CREBBP EP300	1.49e-04	4	26	2	HP:0011087
HumanPheno	Widened distal phalanges	CREBBP EP300	1.49e-04	4	26	2	HP:0006200
HumanPheno	Vascular ring	CREBBP EP300	1.49e-04	4	26	2	HP:0010775
HumanPheno	Hepatic hemangioma	CREBBP EP300	1.49e-04	4	26	2	HP:0031207
HumanPheno	Thin upper lip vermilion	BPTF PUF60 GPC4 ANKRD17 ARID1A CREBBP EP300 CUX1	1.91e-04	339	26	8	HP:0000219
HumanPheno	Thin lips	BPTF PUF60 GPC4 ANKRD17 ARID1A CREBBP EP300 CUX1	1.91e-04	339	26	8	HP:0000213
HumanPheno	Prominent nose	BPTF GPC4 PUM1 CREBBP EP300	1.96e-04	110	26	5	HP:0000448
HumanPheno	Broad hallux phalanx	GPC4 CREBBP EP300	2.23e-04	24	26	3	HP:0010059
HumanPheno	Papillary cystadenoma of the epididymis	CREBBP EP300	2.48e-04	5	26	2	HP:0009715
HumanPheno	Supernumerary cusp	CREBBP EP300	2.48e-04	5	26	2	HP:0033777
HumanPheno	Epididymal neoplasm	CREBBP EP300	2.48e-04	5	26	2	HP:0030421
HumanPheno	Perimembranous ventricular septal defect	PUF60 CREBBP EP300	2.84e-04	26	26	3	HP:0011682
HumanPheno	Flared iliac wing	GPC4 CREBBP EP300	3.18e-04	27	26	3	HP:0002869
HumanPheno	Broad distal phalanx of finger	GPC4 CREBBP EP300	3.18e-04	27	26	3	HP:0009836
HumanPheno	Large foramen magnum	CREBBP EP300	3.71e-04	6	26	2	HP:0002700
HumanPheno	Broad eyebrow	BPTF CREBBP EP300	3.95e-04	29	26	3	HP:0011229
HumanPheno	Long eyelashes	PNPLA6 PUF60 ARID1A CREBBP EP300	4.13e-04	129	26	5	HP:0000527
HumanPheno	Overlapping toe	BPTF PUF60 CREBBP EP300	4.34e-04	72	26	4	HP:0001845
HumanPheno	Deviated nasal septum	CREBBP EP300	5.18e-04	7	26	2	HP:0004411
HumanPheno	Displacement of the urethral meatus	PNPLA6 PUF60 GPC4 ARID1A PUM1 CREBBP EP300 CUX1	5.66e-04	397	26	8	HP:0100627
HumanPheno	Abnormal male urethral meatus morphology	PNPLA6 PUF60 GPC4 ARID1A PUM1 CREBBP EP300 CUX1	5.85e-04	399	26	8	HP:0032076
HumanPheno	Aspiration	LAMA2 CREBBP EP300	6.36e-04	34	26	3	HP:0002835
HumanPheno	Short phalanx of finger	BPTF PUF60 GPC4 ARID1A PUM1 CREBBP EP300	6.42e-04	306	26	7	HP:0009803
HumanPheno	Truncal obesity	BPTF IGFALS CREBBP EP300	7.12e-04	82	26	4	HP:0001956
HumanPheno	Broad phalanx	BPTF PUF60 GPC4 CREBBP EP300	7.77e-04	148	26	5	HP:0006009
HumanPheno	Broad phalanges of the hand	BPTF PUF60 GPC4 CREBBP EP300	7.77e-04	148	26	5	HP:0009768
HumanPheno	Aplasia/Hypoplasia of the phalanges of the hand	BPTF PUF60 GPC4 ARID1A PUM1 CREBBP EP300	8.25e-04	319	26	7	HP:0009767
HumanPheno	Pilomatrixoma	CREBBP EP300	8.82e-04	9	26	2	HP:0030434
HumanPheno	Cervical cord compression	CREBBP EP300	8.82e-04	9	26	2	HP:0002341
HumanPheno	Posterior helix pit	GPC4 EP300	8.82e-04	9	26	2	HP:0008523
HumanPheno	Short hallux	PUF60 GPC4 EP300	8.85e-04	38	26	3	HP:0010109
HumanPheno	Short finger	PUF60 GPC4 ARID1A PUM1 CREBBP EP300 RYR3	9.22e-04	325	26	7	HP:0009381
HumanPheno	Broad finger	BPTF PUF60 GPC4 CREBBP EP300	9.31e-04	154	26	5	HP:0001500
HumanPheno	Thick eyebrow	BPTF PUF60 ARID1A CREBBP EP300	9.31e-04	154	26	5	HP:0000574
HumanPheno	Capillary hemangioma	PUF60 CREBBP EP300	9.55e-04	39	26	3	HP:0005306
HumanPheno	Brachydactyly (hand)	BPTF PUF60 GPC4 ARID1A PUM1 CREBBP EP300 RYR3	9.66e-04	430	26	8	HP:0100667
HumanPheno	Thin vermilion border	BPTF PUF60 GPC4 ANKRD17 ARID1A CREBBP EP300 CUX1	1.01e-03	433	26	8	HP:0000233
HumanPheno	Broad long bones	BPTF PUF60 GPC4 CREBBP EP300	1.02e-03	157	26	5	HP:0005622
HumanPheno	Frontal hirsutism	CREBBP EP300	1.10e-03	10	26	2	HP:0011335
HumanPheno	Left ventricular noncompaction cardiomyopathy	MIB1 RYR2	1.10e-03	10	26	2	HP:0011664
HumanPheno	Aplasia/Hypoplasia of the hallux	PUF60 GPC4 EP300	1.27e-03	43	26	3	HP:0008362
HumanPheno	Sandal gap	BPTF ARID1A CREBBP EP300	1.29e-03	96	26	4	HP:0001852
HumanPheno	Intercostal muscle weakness	LAMA2 ITGA7	1.34e-03	11	26	2	HP:0004878
HumanPheno	Abnormal subclavian artery morphology	CREBBP EP300	1.34e-03	11	26	2	HP:0031251
HumanPheno	Cardiac conduction abnormality	SYNE2 GPC4 CREBBP EP300 RYR2	1.34e-03	167	26	5	HP:0031546
HumanPheno	Reduced social responsiveness	CUX2 PUF60 CNTNAP2 CREBBP EP300	1.45e-03	170	26	5	HP:0012760
HumanPheno	Abnormal hallux phalanx morphology	GPC4 CREBBP EP300	1.55e-03	46	26	3	HP:0010057
HumanPheno	Abnormality of upper lip vermillion	BPTF PUF60 GPC4 ANKRD17 ARID1A CREBBP EP300 CUX1	1.59e-03	464	26	8	HP:0011339
HumanPheno	Unilateral ptosis	PUF60 GPC4	1.60e-03	12	26	2	HP:0007687
HumanPheno	Abnormality of the urethra	PNPLA6 PUF60 GPC4 ARID1A PUM1 CREBBP EP300 CUX1	1.61e-03	465	26	8	HP:0000795
HumanPheno	Abnormal lung lobation	PUF60 GPC4 CUX1	1.65e-03	47	26	3	HP:0002101
HumanPheno	Broad phalanx of the toes	GPC4 CREBBP EP300	1.65e-03	47	26	3	HP:0010174
HumanPheno	Abnormal sternum morphology	PUF60 SYNE2 GPC4 ITGA7 PUM1 CREBBP EP300 CUX1	1.83e-03	474	26	8	HP:0000766
HumanPheno	Aplasia/Hypoplasia of fingers	PUF60 GPC4 ARID1A PUM1 CREBBP EP300 RYR3	1.86e-03	366	26	7	HP:0006265
HumanPheno	Facial grimacing	CREBBP EP300	1.89e-03	13	26	2	HP:0000273
HumanPheno	Keloids	CREBBP EP300	1.89e-03	13	26	2	HP:0010562
Domain	CUT	ONECUT2 CUX2 CUX1	6.66e-07	7	51	3	PS51042
Domain	CUT	ONECUT2 CUX2 CUX1	6.66e-07	7	51	3	PF02376
Domain	CUT_dom	ONECUT2 CUX2 CUX1	6.66e-07	7	51	3	IPR003350
Domain	CUT	ONECUT2 CUX2 CUX1	6.66e-07	7	51	3	SM01109
Domain	Nuc_rcpt_coact_CREBbp	CREBBP EP300	7.31e-06	2	51	2	IPR014744
Domain	HAT_KAT11	CREBBP EP300	7.31e-06	2	51	2	PF08214
Domain	KIX	CREBBP EP300	7.31e-06	2	51	2	PS50952
Domain	ZnF_TAZ	CREBBP EP300	7.31e-06	2	51	2	SM00551
Domain	CBP_P300_HAT	CREBBP EP300	7.31e-06	2	51	2	IPR031162
Domain	DUF902	CREBBP EP300	7.31e-06	2	51	2	PF06001
Domain	-	CREBBP EP300	7.31e-06	2	51	2	1.20.1020.10
Domain	RING_CBP-p300	CREBBP EP300	7.31e-06	2	51	2	IPR010303
Domain	-	CREBBP EP300	7.31e-06	2	51	2	1.10.1630.10
Domain	Creb_binding	CREBBP EP300	7.31e-06	2	51	2	PF09030
Domain	-	CREBBP EP300	7.31e-06	2	51	2	1.10.246.20
Domain	zf-TAZ	CREBBP EP300	7.31e-06	2	51	2	PF02135
Domain	ZF_TAZ	CREBBP EP300	7.31e-06	2	51	2	PS50134
Domain	Histone_AcTrfase_Rtt109/CBP	CREBBP EP300	7.31e-06	2	51	2	IPR013178
Domain	KAT11	CREBBP EP300	7.31e-06	2	51	2	SM01250
Domain	Znf_TAZ	CREBBP EP300	7.31e-06	2	51	2	IPR000197
Domain	KIX_dom	CREBBP EP300	7.31e-06	2	51	2	IPR003101
Domain	KIX	CREBBP EP300	7.31e-06	2	51	2	PF02172
Domain	CBP_P300_HAT	CREBBP EP300	7.31e-06	2	51	2	PS51727
Domain	ZZ	MIB1 CREBBP EP300	1.52e-05	18	51	3	PF00569
Domain	ZF_ZZ_2	MIB1 CREBBP EP300	1.52e-05	18	51	3	PS50135
Domain	ZF_ZZ_1	MIB1 CREBBP EP300	1.52e-05	18	51	3	PS01357
Domain	Znf_ZZ	MIB1 CREBBP EP300	1.80e-05	19	51	3	IPR000433
Domain	ZnF_ZZ	MIB1 CREBBP EP300	1.80e-05	19	51	3	SM00291
Domain	Ryanrecept_TM4-6	RYR2 RYR3	2.19e-05	3	51	2	IPR009460
Domain	RyR	RYR2 RYR3	2.19e-05	3	51	2	PF02026
Domain	Ryanodine_rcpt	RYR2 RYR3	2.19e-05	3	51	2	IPR003032
Domain	RR_TM4-6	RYR2 RYR3	2.19e-05	3	51	2	PF06459
Domain	Ryan_recept	RYR2 RYR3	2.19e-05	3	51	2	IPR013333
Domain	ConA-like_dom	LMAN2L CNTNAP2 LAMA2 EGFLAM RYR2 RYR3	2.81e-05	219	51	6	IPR013320
Domain	Bromodomain_CS	BPTF CREBBP EP300	4.77e-05	26	51	3	IPR018359
Domain	-	ONECUT2 CUX2 CUX1	5.36e-05	27	51	3	1.10.260.40
Domain	Lambda_DNA-bd_dom	ONECUT2 CUX2 CUX1	6.67e-05	29	51	3	IPR010982
Domain	RIH_assoc	RYR2 RYR3	1.09e-04	6	51	2	PF08454
Domain	RIH_assoc-dom	RYR2 RYR3	1.09e-04	6	51	2	IPR013662
Domain	RIH_dom	RYR2 RYR3	1.09e-04	6	51	2	IPR000699
Domain	Nuc_rcpt_coact	CREBBP EP300	1.09e-04	6	51	2	IPR009110
Domain	Ins145_P3_rcpt	RYR2 RYR3	1.09e-04	6	51	2	IPR014821
Domain	Ryanodine_recept-rel	RYR2 RYR3	1.09e-04	6	51	2	IPR015925
Domain	-	RYR2 RYR3	1.09e-04	6	51	2	1.25.10.30
Domain	RYDR_ITPR	RYR2 RYR3	1.09e-04	6	51	2	PF01365
Domain	Ins145_P3_rec	RYR2 RYR3	1.09e-04	6	51	2	PF08709
Domain	-	LMAN2L CNTNAP2 LAMA2 EGFLAM	1.31e-04	95	51	4	2.60.120.200
Domain	BROMODOMAIN_1	BPTF CREBBP EP300	1.40e-04	37	51	3	PS00633
Domain	Bromodomain	BPTF CREBBP EP300	1.51e-04	38	51	3	PF00439
Domain	LAM_G_DOMAIN	CNTNAP2 LAMA2 EGFLAM	1.51e-04	38	51	3	PS50025
Domain	Laminin_G_2	CNTNAP2 LAMA2 EGFLAM	1.76e-04	40	51	3	PF02210
Domain	BROMODOMAIN_2	BPTF CREBBP EP300	1.90e-04	41	51	3	PS50014
Domain	BROMO	BPTF CREBBP EP300	2.04e-04	42	51	3	SM00297
Domain	Bromodomain	BPTF CREBBP EP300	2.04e-04	42	51	3	IPR001487
Domain	-	BPTF CREBBP EP300	2.04e-04	42	51	3	1.20.920.10
Domain	LamG	CNTNAP2 LAMA2 EGFLAM	2.35e-04	44	51	3	SM00282
Domain	MIR	RYR2 RYR3	3.24e-04	10	51	2	PS50919
Domain	MIR	RYR2 RYR3	3.24e-04	10	51	2	PF02815
Domain	MIR	RYR2 RYR3	3.24e-04	10	51	2	SM00472
Domain	MIR_motif	RYR2 RYR3	3.24e-04	10	51	2	IPR016093
Domain	Laminin_G_1	LAMA2 EGFLAM	3.96e-04	11	51	2	PF00054
Domain	Laminin_G	CNTNAP2 LAMA2 EGFLAM	5.32e-04	58	51	3	IPR001791
Domain	Neurexin-like	CNTNAP2 CADM2	6.51e-04	14	51	2	IPR003585
Domain	4.1m	CNTNAP2 CADM2	6.51e-04	14	51	2	SM00294
Domain	Homeodomain-like	MTA2 ONECUT2 CUX2 SIX4 CUX1	2.07e-03	332	51	5	IPR009057
Domain	Homeobox	ONECUT2 CUX2 SIX4 CUX1	3.78e-03	234	51	4	PF00046
Domain	HOMEOBOX_1	ONECUT2 CUX2 SIX4 CUX1	3.90e-03	236	51	4	PS00027
Domain	HOX	ONECUT2 CUX2 SIX4 CUX1	3.96e-03	237	51	4	SM00389
Domain	HOMEOBOX_2	ONECUT2 CUX2 SIX4 CUX1	4.08e-03	239	51	4	PS50071
Domain	Homeobox_dom	ONECUT2 CUX2 SIX4 CUX1	4.08e-03	239	51	4	IPR001356
Domain	EGF-like_dom	HMCN2 CNTNAP2 LAMA2 EGFLAM	4.72e-03	249	51	4	IPR000742
Domain	EGF_1	HMCN2 CNTNAP2 LAMA2 EGFLAM	5.13e-03	255	51	4	PS00022
Pathway	REACTOME_RUNX3_REGULATES_NOTCH_SIGNALING	MAML2 CREBBP EP300	4.58e-06	14	34	3	M27808
Pathway	REACTOME_SIGNALING_BY_NOTCH3	MIB1 MAML2 CREBBP EP300	5.53e-06	49	34	4	M618
Pathway	REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS	MAML2 CREBBP EP300	7.03e-06	16	34	3	M27121
Pathway	REACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER	MIB1 MAML2 CREBBP EP300	1.09e-05	58	34	4	M29616
Pathway	REACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	MAML2 CREBBP EP300	1.42e-05	20	34	3	M27881
Pathway	BIOCARTA_VDR_PATHWAY	ARID1A CREBBP EP300	1.91e-05	22	34	3	MM1370
Pathway	BIOCARTA_VDR_PATHWAY	ARID1A CREBBP EP300	2.51e-05	24	34	3	M13404
Pathway	REACTOME_NOTCH3_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	MAML2 CREBBP EP300	2.84e-05	25	34	3	M27880
Pathway	REACTOME_SIGNALING_BY_NOTCH1	MIB1 MAML2 CREBBP EP300	2.88e-05	74	34	4	M616
Pathway	REACTOME_LAMININ_INTERACTIONS	COL4A3 LAMA2 ITGA7	4.98e-05	30	34	3	M27216
Pathway	BIOCARTA_PELP1_PATHWAY	CREBBP EP300	5.62e-05	5	34	2	MM1575
Pathway	REACTOME_NFE2L2_REGULATING_INFLAMMATION_ASSOCIATED_GENES	CREBBP EP300	5.62e-05	5	34	2	M48020
Pathway	REACTOME_LRR_FLII_INTERACTING_PROTEIN_1_LRRFIP1_ACTIVATES_TYPE_I_IFN_PRODUCTION	CREBBP EP300	5.62e-05	5	34	2	M27228
Pathway	REACTOME_NFE2L2_REGULATING_ER_STRESS_ASSOCIATED_GENES	CREBBP EP300	5.62e-05	5	34	2	M48023
Pathway	REACTOME_SIGNALING_BY_NOTCH2	MIB1 MAML2 EP300	6.66e-05	33	34	3	M604
Pathway	WP_TYPE_2_PAPILLARY_RENAL_CELL_CARCINOMA	CREBBP EP300 CADM2	7.29e-05	34	34	3	M39771
Pathway	BIOCARTA_PELP1_PATHWAY	CREBBP EP300	8.42e-05	6	34	2	M22062
Pathway	BIOCARTA_PPARG_PATHWAY	CREBBP EP300	1.18e-04	7	34	2	MM1573
Pathway	REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT	MAML2 CREBBP EP300	1.38e-04	42	34	3	M17541
Pathway	BIOCARTA_PPARG_PATHWAY	CREBBP EP300	1.57e-04	8	34	2	M22058
Pathway	REACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES	CREBBP EP300	1.57e-04	8	34	2	M48022
Pathway	REACTOME_REGULATION_OF_NFE2L2_GENE_EXPRESSION	CREBBP EP300	1.57e-04	8	34	2	M48024
Pathway	REACTOME_NFE2L2_REGULATES_PENTOSE_PHOSPHATE_PATHWAY_GENES	CREBBP EP300	1.57e-04	8	34	2	M46443
Pathway	KEGG_NOTCH_SIGNALING_PATHWAY	MAML2 CREBBP EP300	1.93e-04	47	34	3	M7946
Pathway	KEGG_MEDICUS_REFERENCE_TLR3_IRF3_SIGNALING_PATHWAY	CREBBP EP300	2.01e-04	9	34	2	M47451
Pathway	PID_HES_HEY_PATHWAY	MAML2 CREBBP EP300	2.06e-04	48	34	3	M288
Pathway	REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	MAML2 CREBBP EP300	2.06e-04	48	34	3	M611
Pathway	REACTOME_RUNX3_REGULATES_NOTCH_SIGNALING	MAML2 EP300	2.51e-04	10	34	2	MM15535
Pathway	REACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION	CREBBP EP300	2.51e-04	10	34	2	M27945
Pathway	BIOCARTA_CARM1_PATHWAY	CREBBP EP300	3.06e-04	11	34	2	MM1521
Pathway	REACTOME_NFE2L2_REGULATING_TUMORIGENIC_GENES	CREBBP EP300	3.06e-04	11	34	2	M48021
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	RYR2 RYR3	3.06e-04	11	34	2	M47958
Pathway	REACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR	CREBBP EP300	3.06e-04	11	34	2	M26924
Pathway	BIOCARTA_CARM1_PATHWAY	CREBBP EP300	3.67e-04	12	34	2	M7968
Pathway	REACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS	CREBBP EP300	3.67e-04	12	34	2	M27765
Pathway	REACTOME_NOTCH2_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	MAML2 EP300	3.67e-04	12	34	2	M27159
Pathway	PID_NOTCH_PATHWAY	MIB1 MAML2 EP300	3.80e-04	59	34	3	M17
Pathway	WP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING	RYR2 RYR3	4.33e-04	13	34	2	M39589
Pathway	WP_PATHWAYS_AFFECTED_IN_ADENOID_CYSTIC_CARCINOMA	ARID1A CREBBP EP300	5.06e-04	65	34	3	M39682
Pathway	PID_HDAC_CLASSI_PATHWAY	MTA2 CREBBP EP300	5.29e-04	66	34	3	M101
Pathway	PID_INTEGRIN1_PATHWAY	COL4A3 LAMA2 ITGA7	5.29e-04	66	34	3	M18
Pathway	BIOCARTA_RELA_PATHWAY	CREBBP EP300	5.81e-04	15	34	2	MM1339
Pathway	BIOCARTA_RELA_PATHWAY	CREBBP EP300	5.81e-04	15	34	2	M10183
Pathway	REACTOME_LAMININ_INTERACTIONS	COL4A3 ITGA7	5.81e-04	15	34	2	MM14922
Pathway	BIOCARTA_PITX2_PATHWAY	CREBBP EP300	5.81e-04	15	34	2	MM1439
Pathway	REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY	CREBBP EP300	5.81e-04	15	34	2	M953
Pathway	REACTOME_FORMATION_OF_PARAXIAL_MESODERM	MAML2 CREBBP EP300	6.02e-04	69	34	3	M46439
Pathway	BIOCARTA_IL7_PATHWAY	CREBBP EP300	6.63e-04	16	34	2	M1296
Pathway	BIOCARTA_IL7_PATHWAY	CREBBP EP300	6.63e-04	16	34	2	MM1420
Pathway	BIOCARTA_PITX2_PATHWAY	CREBBP EP300	6.63e-04	16	34	2	M8516
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES	CREBBP EP300	6.63e-04	16	34	2	M27940
Pathway	WP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY	LAMA2 ITGA7 RYR2	7.39e-04	74	34	3	M39462
Pathway	KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC	LAMA2 ITGA7 RYR2	7.39e-04	74	34	3	M16376
Pathway	BIOCARTA_TGFB_PATHWAY	CREBBP EP300	7.51e-04	17	34	2	MM1509
Pathway	REACTOME_ZYGOTIC_GENOME_ACTIVATION_ZGA	CREBBP EP300	7.51e-04	17	34	2	M48025
Pathway	REACTOME_ECM_PROTEOGLYCANS	COL4A3 LAMA2 ITGA7	7.99e-04	76	34	3	M27219
Pathway	REACTOME_SIGNALING_BY_NOTCH1	MAML2 EP300	8.43e-04	18	34	2	MM14775
Pathway	REACTOME_RORA_ACTIVATES_GENE_EXPRESSION	CREBBP EP300	8.43e-04	18	34	2	M26942
Pathway	BIOCARTA_TGFB_PATHWAY	CREBBP EP300	9.41e-04	19	34	2	M18933
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	RYR2 RYR3	9.41e-04	19	34	2	M47760
Pathway	REACTOME_NFE2L2_REGULATING_ANTI_OXIDANT_DETOXIFICATION_ENZYMES	CREBBP EP300	9.41e-04	19	34	2	M46442
Pathway	REACTOME_SIGNALING_BY_NOTCH4	MAML2 CREBBP EP300	9.97e-04	82	34	3	M594
Pathway	KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM	LAMA2 ITGA7 RYR2	1.03e-03	83	34	3	M8728
Pathway	WP_HEMATOPOIETIC_STEM_CELL_GENE_REGULATION_BY_GABP_ALPHABETA_COMPLEX	CREBBP EP300	1.15e-03	21	34	2	M39593
Pathway	REACTOME_CD209_DC_SIGN_SIGNALING	CREBBP EP300	1.15e-03	21	34	2	M27485
Pathway	BIOCARTA_NTHI_PATHWAY	CREBBP EP300	1.27e-03	22	34	2	MM1443
Pathway	KEGG_DILATED_CARDIOMYOPATHY	LAMA2 ITGA7 RYR2	1.30e-03	90	34	3	M835
Pathway	BIOCARTA_NTHI_PATHWAY	CREBBP EP300	1.38e-03	23	34	2	M2821
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX3	MAML2 CREBBP EP300	1.57e-03	96	34	3	M27784
Pathway	REACTOME_RSV_HOST_INTERACTIONS	GPC4 CREBBP EP300	1.67e-03	98	34	3	M48247
Pathway	BIOCARTA_CARM_ER_PATHWAY	CREBBP EP300	1.77e-03	26	34	2	M2499
Pathway	PID_HDAC_CLASSIII_PATHWAY	CREBBP EP300	1.77e-03	26	34	2	M32
Pathway	REACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION	MTA2 TAF1C EP300	2.03e-03	105	34	3	M27425
Pathway	REACTOME_ATTENUATION_PHASE	CREBBP EP300	2.05e-03	28	34	2	M27254
Pathway	REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY	MAML2 CREBBP	2.05e-03	28	34	2	M6177
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION	MTA2 EP300	2.20e-03	29	34	2	MM15340
Pathway	REACTOME_ADIPOGENESIS	MTA2 CREBBP EP300	2.32e-03	110	34	3	M48259
Pathway	PID_RETINOIC_ACID_PATHWAY	CREBBP EP300	2.35e-03	30	34	2	M207
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION	MTA2 EP300	2.35e-03	30	34	2	M27637
Pathway	REACTOME_POSITIVE_EPIGENETIC_REGULATION_OF_RRNA_EXPRESSION	TAF1C EP300	2.35e-03	30	34	2	MM15173
Pathway	REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION	CREBBP EP300	2.35e-03	30	34	2	M936
Pathway	WP_INITIATION_OF_TRANSCRIPTION_AND_TRANSLATION_ELONGATION_AT_THE_HIV1_LTR	CREBBP EP300	2.68e-03	32	34	2	M39521
Pathway	REACTOME_SIGNALING_BY_NOTCH	MIB1 MAML2 CREBBP EP300	2.78e-03	246	34	4	M10189
Pathway	REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING	MAML2 CREBBP EP300	2.90e-03	119	34	3	M607
Pathway	REACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_PATHWAY	GPC4 CREBBP EP300	2.97e-03	120	34	3	M48233
Pathway	PID_HIF2PATHWAY	CREBBP EP300	3.02e-03	34	34	2	M44
Pathway	REACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN	ARID1A EP300	3.02e-03	34	34	2	MM15531
Pathway	REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION	MTA2 TAF1C ARID1A EP300	3.12e-03	254	34	4	M27131
Pathway	REACTOME_EVASION_BY_RSV_OF_HOST_INTERFERON_RESPONSES	CREBBP EP300	3.20e-03	35	34	2	M48246
Pathway	REACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN	ARID1A EP300	3.57e-03	37	34	2	M27797
Pathway	REACTOME_GASTRULATION	MAML2 CREBBP EP300	3.64e-03	129	34	3	M46433
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_THE_AP_2_TFAP2_FAMILY_OF_TRANSCRIPTION_FACTORS	CREBBP EP300	3.76e-03	38	34	2	M27757
Pathway	REACTOME_HSF1_DEPENDENT_TRANSACTIVATION	CREBBP EP300	3.76e-03	38	34	2	M27255
Pathway	REACTOME_SIGNALING_BY_NOTCH	MAML2 EP300	3.96e-03	39	34	2	MM14604
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	MTA2 ARID1A CREBBP EP300	3.99e-03	272	34	4	M29619
Pathway	PID_FOXM1_PATHWAY	CREBBP EP300	4.16e-03	40	34	2	M176
Pathway	PID_IFNG_PATHWAY	CREBBP EP300	4.16e-03	40	34	2	M161
Pathway	REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS	MIB1 MAML2 CREBBP EP300 CUX1	4.78e-03	464	34	5	M27547
Pathway	PID_HNF3A_PATHWAY	CREBBP EP300	5.01e-03	44	34	2	M285
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS	CREBBP EP300	5.01e-03	44	34	2	M27295
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	SP2 SYNE2 GPC4 SIX4 ARID1A NCKAP5L CREBBP EP300 CUX1	7.33e-09	398	52	9	35016035
Pubmed	Human transcription factor protein interaction networks.	BPTF SP2 SYNE2 DDX54 ANKRD17 TPGS1 SIX4 MLLT10 ARID1A PUM1 MCRIP2 CREBBP EP300 CUX1	1.50e-08	1429	52	14	35140242
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	MTA2 ONECUT2 BPTF SP2 CUX2 SIX4 MLLT10 ZNF236 ARID1A PKHD1L1 CUX1	2.52e-08	808	52	11	20412781
Pubmed	Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation.	MAML2 CREBBP EP300	6.28e-08	6	52	3	15961999
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	BPTF SIX4 ARID1A EP300 CUX1	1.63e-07	83	52	5	28794006
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	PNPLA6 PUF60 DDX54 MIB1 ANKRD17 TPGS1 PUM1 EP300 CCDC33	4.10e-07	639	52	9	23443559
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MTA2 BPTF PNPLA6 HMCN2 TAF1C CRNN ANKRD17 ARID1A NCKAP5L CREBBP EP300	6.39e-07	1116	52	11	31753913
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	MTA2 SP2 CUX2 RCBTB1 SIX4 MLLT10 ARID1A CREBBP CUX1	9.72e-07	709	52	9	22988430
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	MTA2 BPTF RAPH1 PUF60 ARID1A CREBBP EP300 CUX1	1.50e-06	549	52	8	38280479
Pubmed	Loss of p300 accelerates MDS-associated leukemogenesis.	CREBBP EP300	2.19e-06	2	52	2	27881875
Pubmed	Cux1 and Cux2 selectively target basal and apical dendritic compartments of layer II-III cortical neurons.	CUX2 CUX1	2.19e-06	2	52	2	25059644
Pubmed	Cux-1 and Cux-2 control the development of Reelin expressing cortical interneurons.	CUX2 CUX1	2.19e-06	2	52	2	18327765
Pubmed	Molecular characterization of the histone acetyltransferase CREBBP/EP300 genes in myeloid neoplasia.	CREBBP EP300	2.19e-06	2	52	2	34845315
Pubmed	A unique variant of a homeobox gene related to Drosophila cut is expressed in mouse testis.	CUX2 CUX1	2.19e-06	2	52	2	8879483
Pubmed	p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.	CREBBP EP300	2.19e-06	2	52	2	19729597
Pubmed	Endogenous CCAAT/enhancer binding protein beta and p300 are both regulated by growth hormone to mediate transcriptional activation.	CREBBP EP300	2.19e-06	2	52	2	15860545
Pubmed	Further delineation of an entity caused by CREBBP and EP300 mutations but not resembling Rubinstein-Taybi syndrome.	CREBBP EP300	2.19e-06	2	52	2	29460469
Pubmed	Expression of p300 and CBP is associated with poor prognosis in small cell lung cancer.	CREBBP EP300	2.19e-06	2	52	2	24551300
Pubmed	Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.	RYR2 RYR3	2.19e-06	2	52	2	21531043
Pubmed	Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma.	CREBBP EP300	2.19e-06	2	52	2	33911074
Pubmed	The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300.	CREBBP EP300	2.19e-06	2	52	2	9018065
Pubmed	Coactivators p300 and CBP maintain the identity of mouse embryonic stem cells by mediating long-range chromatin structure.	CREBBP EP300	2.19e-06	2	52	2	24648406
Pubmed	CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity.	CREBBP EP300	2.19e-06	2	52	2	30135524
Pubmed	Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells.	RYR2 RYR3	2.19e-06	2	52	2	16678258
Pubmed	CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer.	CREBBP EP300	2.19e-06	2	52	2	39287984
Pubmed	Distribution of co-activators CBP and p300 during mouse oocyte and embryo development.	CREBBP EP300	2.19e-06	2	52	2	16596650
Pubmed	The p300 and CBP Transcriptional Coactivators Are Required for β-Cell and α-Cell Proliferation.	CREBBP EP300	2.19e-06	2	52	2	29217654
Pubmed	Transgenic overexpression of the α7 integrin reduces muscle pathology and improves viability in the dy(W) mouse model of merosin-deficient congenital muscular dystrophy type 1A.	LAMA2 ITGA7	2.19e-06	2	52	2	21652631
Pubmed	Exon deletions of the EP300 and CREBBP genes in two children with Rubinstein-Taybi syndrome detected by aCGH.	CREBBP EP300	2.19e-06	2	52	2	20717166
Pubmed	CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate.	CUX2 CUX1	2.19e-06	2	52	2	35581205
Pubmed	Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP.	CREBBP EP300	2.19e-06	2	52	2	10049825
Pubmed	CBP/p300 acetyltransferase activity in hematologic malignancies.	CREBBP EP300	2.19e-06	2	52	2	27380996
Pubmed	CREBBP and p300 lysine acetyl transferases in the DNA damage response.	CREBBP EP300	2.19e-06	2	52	2	29170789
Pubmed	The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.	CREBBP EP300	2.19e-06	2	52	2	25893291
Pubmed	Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300.	CREBBP EP300	2.19e-06	2	52	2	11559821
Pubmed	Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis.	CREBBP EP300	2.19e-06	2	52	2	21555743
Pubmed	CBP/p300 induction is required for retinoic acid sensitivity in human mammary cells.	CREBBP EP300	2.19e-06	2	52	2	12646247
Pubmed	CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.	CREBBP EP300	2.19e-06	2	52	2	32576962
Pubmed	Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology.	CREBBP EP300	2.19e-06	2	52	2	19822209
Pubmed	A specific CBP/p300-dependent gene expression programme drives the metabolic remodelling in late stages of spermatogenesis.	CREBBP EP300	2.19e-06	2	52	2	24522976
Pubmed	Histone acetyltransferase activities of cAMP-regulated enhancer-binding protein and p300 in tissues of fetal, young, and old mice.	CREBBP EP300	2.19e-06	2	52	2	11867645
Pubmed	CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.	CREBBP EP300	2.19e-06	2	52	2	21847097
Pubmed	Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.	RYR2 RYR3	2.19e-06	2	52	2	8898078
Pubmed	Expression of the nuclear coactivators CBP and p300 in developing craniofacial tissue.	CREBBP EP300	2.19e-06	2	52	2	11963968
Pubmed	p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.	CREBBP EP300	2.19e-06	2	52	2	34813504
Pubmed	Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300.	CREBBP EP300	2.19e-06	2	52	2	9528808
Pubmed	Analysis of genetic stability at the EP300 and CREBBP loci in a panel of cancer cell lines.	CREBBP EP300	2.19e-06	2	52	2	12696060
Pubmed	The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.	RYR2 RYR3	2.19e-06	2	52	2	14550562
Pubmed	Rubinstein-Taybi Syndrome	CREBBP EP300	2.19e-06	2	52	2	20301699
Pubmed	CBP Is Required for Establishing Adaptive Gene Programs in the Adult Mouse Brain.	CREBBP EP300	2.19e-06	2	52	2	36109165
Pubmed	Potential biomarker of metformin action.	CREBBP EP300	2.19e-06	2	52	2	24639469
Pubmed	The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels.	CREBBP EP300	2.19e-06	2	52	2	37816914
Pubmed	Expression of a cut-related homeobox gene in developing and polycystic mouse kidney.	CUX2 CUX1	2.19e-06	2	52	2	8840273
Pubmed	Retinoids and retinoic acid receptors regulate growth arrest and apoptosis in human mammary epithelial cells and modulate expression of CBP/p300.	CREBBP EP300	2.19e-06	2	52	2	12242694
Pubmed	Binding of p300/CBP co-activators by polyoma large T antigen.	CREBBP EP300	2.19e-06	2	52	2	11438528
Pubmed	Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators.	CREBBP EP300	2.19e-06	2	52	2	10918613
Pubmed	CBP/p300 Drives the Differentiation of Regulatory T Cells through Transcriptional and Non-Transcriptional Mechanisms.	CREBBP EP300	2.19e-06	2	52	2	31182547
Pubmed	Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity.	CREBBP EP300	2.19e-06	2	52	2	35502657
Pubmed	Rubinstein-Taybi syndrome in a Saudi boy with distinct features and variants in both the CREBBP and EP300 genes: a case report.	CREBBP EP300	2.19e-06	2	52	2	30635043
Pubmed	p300 and cAMP response element-binding protein-binding protein in skeletal muscle homeostasis, contractile function, and survival.	CREBBP EP300	2.19e-06	2	52	2	31898871
Pubmed	Phenotype and genotype in 52 patients with Rubinstein-Taybi syndrome caused by EP300 mutations.	CREBBP EP300	2.19e-06	2	52	2	27648933
Pubmed	Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity.	CREBBP EP300	2.19e-06	2	52	2	30888860
Pubmed	Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.	CREBBP EP300	2.19e-06	2	52	2	27881443
Pubmed	Spatiotemporal expression of histone acetyltransferases, p300 and CBP, in developing embryonic hearts.	CREBBP EP300	2.19e-06	2	52	2	19272189
Pubmed	Developmentally regulated expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse embryogenesis.	CREBBP EP300	2.19e-06	2	52	2	10610021
Pubmed	Emerging roles of p300/CBP in autophagy and autophagy-related human disorders.	CREBBP EP300	2.19e-06	2	52	2	37314181
Pubmed	Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal.	CREBBP EP300	2.19e-06	2	52	2	12397173
Pubmed	CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding.	CREBBP EP300	2.19e-06	2	52	2	15641773
Pubmed	Cux1 Enables Interhemispheric Connections of Layer II/III Neurons by Regulating Kv1-Dependent Firing.	CUX2 CUX1	2.19e-06	2	52	2	26804994
Pubmed	Differential contribution of p300 and CBP to regulatory element acetylation in mESCs.	CREBBP EP300	2.19e-06	2	52	2	32690000
Pubmed	Interaction of human immunodeficiency virus type 1 Tat with the transcriptional coactivators p300 and CREB binding protein.	CREBBP EP300	2.19e-06	2	52	2	9733868
Pubmed	CBP/p300 antagonises EGFR-Ras-Erk signalling and suppresses increased Ras-Erk signalling-induced tumour formation in mice.	CREBBP EP300	2.19e-06	2	52	2	30953353
Pubmed	Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.	CREBBP EP300	2.19e-06	2	52	2	21803292
Pubmed	HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter.	CREBBP EP300	2.19e-06	2	52	2	9811832
Pubmed	Two independent regions of simian virus 40 T antigen increase CBP/p300 levels, alter patterns of cellular histone acetylation, and immortalize primary cells.	CREBBP EP300	2.19e-06	2	52	2	24089570
Pubmed	Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes.	RYR2 RYR3	2.19e-06	2	52	2	14985349
Pubmed	Rubinstein-Taybi syndrome in Chinese population with four novel mutations.	CREBBP EP300	2.19e-06	2	52	2	33063428
Pubmed	P300 binds to and acetylates MTA2 to promote colorectal cancer cells growth.	MTA2 EP300	2.19e-06	2	52	2	24468085
Pubmed	Deletion of integrin α7 subunit does not aggravate the phenotype of laminin α2 chain-deficient mice.	LAMA2 ITGA7	2.19e-06	2	52	2	26355035
Pubmed	EP300/CBP is crucial for cAMP-PKA pathway to alleviate podocyte dedifferentiation via targeting Notch3 signaling.	CREBBP EP300	2.19e-06	2	52	2	34506759
Pubmed	Lack of somatic mutations in the catalytic domains of CREBBP and EP300 genes implies a role for histone deacetylase inhibition in myeloproliferative neoplasms.	CREBBP EP300	2.19e-06	2	52	2	22177454
Pubmed	Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease.	CREBBP EP300	2.19e-06	2	52	2	15706485
Pubmed	AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer.	CREBBP EP300	2.19e-06	2	52	2	39266679
Pubmed	A boy with classical Rubinstein-Taybi syndrome but no detectable mutation in the CREBBP and EP300 genes.	CREBBP EP300	2.19e-06	2	52	2	22303793
Pubmed	Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function.	CREBBP EP300	2.19e-06	2	52	2	34732714
Pubmed	Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.	CREBBP EP300	2.19e-06	2	52	2	34019788
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	MTA2 BPTF ARID1A CREBBP EP300	3.85e-06	157	52	5	30186101
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	MTA2 PNPLA6 PUF60 TAF1C DDX54 CRNN ANKRD17 PUM1 CUX1	4.16e-06	847	52	9	35850772
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	SYNE2 MIB1 ANKRD17 ARID1A CREBBP EP300 CUX1 RYR2	4.54e-06	638	52	8	31182584
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	BPTF PUF60 RCBTB1 ANKRD17 SIX4 PUM1 CREBBP EP300 CUX1	4.57e-06	857	52	9	25609649
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	VWA5B2 MTA2 LMAN2L PNPLA6 PUF60 MLLT10 ZNF236 ARID1A PUM1 EP300	4.73e-06	1105	52	10	35748872
Pubmed	Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.	MTA2 BPTF CREBBP EP300	4.99e-06	75	52	4	25593309
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MTA2 BPTF PUF60 SYNE2 DDX54 ANKRD17 ARID1A PUM1	5.38e-06	653	52	8	22586326
Pubmed	Dendrite development regulated by CREST, a calcium-regulated transcriptional activator.	CREBBP EP300	6.57e-06	3	52	2	14716005
Pubmed	The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB.	CREBBP EP300	6.57e-06	3	52	2	18070920
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR2 RYR3	6.57e-06	3	52	2	18403125
Pubmed	The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression.	CREBBP EP300	6.57e-06	3	52	2	21967847
Pubmed	CBP and p300 are essential for renin cell identity and morphological integrity of the kidney.	CREBBP EP300	6.57e-06	3	52	2	19252086
Pubmed	Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP.	CREBBP EP300	6.57e-06	3	52	2	27903646
Pubmed	Inhibition of p300/CBP by early B-cell factor.	CREBBP EP300	6.57e-06	3	52	2	12748286
Interaction	HNF1B interactions	BPTF SIX4 MLLT10 ARID1A CREBBP EP300 CUX1	5.54e-07	190	52	7	int:HNF1B
Interaction	FEV interactions	SP2 SIX4 MLLT10 ARID1A CREBBP EP300 CUX1	8.65e-07	203	52	7	int:FEV
Interaction	SRF interactions	BPTF SP2 GPC4 SIX4 CREBBP CUX1	1.52e-06	139	52	6	int:SRF
Interaction	E2F5 interactions	MIB1 ARID1A CREBBP EP300	2.18e-06	36	52	4	int:E2F5
Interaction	TOP3B interactions	VWA5B2 MTA2 LMAN2L PNPLA6 TOMM22 PUF60 MIB1 GPC4 ANKRD17 MLLT10 ZNF236 ARID1A PUM1 MCRIP2 EP300	2.79e-06	1470	52	15	int:TOP3B
Interaction	MAML2 interactions	MAML2 CREBBP EP300	1.07e-05	17	52	3	int:MAML2
Interaction	WWTR1 interactions	MTA2 BPTF RAPH1 PUF60 ARID1A CREBBP EP300 CUX1	1.16e-05	422	52	8	int:WWTR1
Interaction	TBXT interactions	SIX4 ARID1A CREBBP EP300 CUX1	1.21e-05	116	52	5	int:TBXT
Interaction	SMG7 interactions	MIB1 ANKRD17 SIX4 MLLT10 ARID1A PUM1 CREBBP	1.69e-05	319	52	7	int:SMG7
Interaction	CNTN2 interactions	CNTNAP2 CREBBP EP300	3.16e-05	24	52	3	int:CNTN2
Interaction	HOXB7 interactions	ANKRD17 CREBBP EP300	4.04e-05	26	52	3	int:HOXB7
Interaction	IRF1 interactions	SP2 ARID1A CREBBP EP300	6.23e-05	83	52	4	int:IRF1
Interaction	HOXD4 interactions	ANKRD17 CREBBP EP300	6.26e-05	30	52	3	int:HOXD4
Interaction	PGR interactions	BPTF DDX54 ARID1A EP300	6.53e-05	84	52	4	int:PGR
Interaction	ARID1A interactions	MTA2 BPTF IGFALS ARID1A CREBBP EP300	7.50e-05	276	52	6	int:ARID1A
Interaction	N4BP2 interactions	MIB1 ANKRD17 CREBBP EP300	8.18e-05	89	52	4	int:N4BP2
Interaction	TLX1 interactions	SIX4 ARID1A CREBBP EP300 CUX1	8.71e-05	175	52	5	int:TLX1
Interaction	TEAD1 interactions	BPTF ARID1A CREBBP EP300 CUX1	8.95e-05	176	52	5	int:TEAD1
Interaction	FOXI1 interactions	MLLT10 ARID1A CREBBP EP300	9.31e-05	92	52	4	int:FOXI1
Interaction	HDAC1 interactions	MTA2 BPTF RAPH1 FOLH1 SYNE2 ANKRD17 TPGS1 ARID1A CREBBP EP300 CUX1	9.95e-05	1108	52	11	int:HDAC1
Interaction	CPAP interactions	DDX54 MIB1 TPGS1 MLLT10 CREBBP	1.05e-04	182	52	5	int:CPAP
Interaction	HOXB2 interactions	SYNE2 CREBBP EP300	1.09e-04	36	52	3	int:HOXB2
Interaction	LHX3 interactions	SYNE2 SIX4 ARID1A CREBBP CUX1	1.13e-04	185	52	5	int:LHX3
Interaction	SOX9 interactions	ARID1A CREBBP EP300 CUX1	1.14e-04	97	52	4	int:SOX9
Interaction	KLF1 interactions	ARID1A CREBBP EP300	1.18e-04	37	52	3	int:KLF1
Interaction	CHD3 interactions	MTA2 BPTF KRT78 PUF60 DDX54 ARID1A CREBBP EP300 CUX1	1.23e-04	757	52	9	int:CHD3
Interaction	CLOCK interactions	PUM1 NCKAP5L CREBBP EP300	1.39e-04	102	52	4	int:CLOCK
Interaction	MYOD1 interactions	BPTF ARID1A CREBBP EP300 CUX1	1.41e-04	194	52	5	int:MYOD1
Interaction	SMAD3 interactions	MTA2 BPTF ARID1A CREBBP EP300 ST6GALNAC2 CCDC33	1.42e-04	447	52	7	int:SMAD3
Interaction	KLF5 interactions	MTA2 MLLT10 ARID1A CREBBP EP300	1.45e-04	195	52	5	int:KLF5
Interaction	GATA2 interactions	SIX4 ARID1A CREBBP EP300 CUX1	1.59e-04	199	52	5	int:GATA2
Interaction	NR3C1 interactions	MTA2 SYNE2 DDX54 MIB1 ANKRD17 ARID1A CREBBP EP300 CUX1 RYR2	1.65e-04	974	52	10	int:NR3C1
Interaction	DOT1L interactions	MTA2 PNPLA6 PUF60 TAF1C DDX54 CRNN MLLT10 PUM1 CUX1	1.98e-04	807	52	9	int:DOT1L
Interaction	HNRNPC interactions	MTA2 CUX2 TOMM22 PUF60 ARID1A PUM1 EP300 CCDC33	2.03e-04	634	52	8	int:HNRNPC
Interaction	HOXB3 interactions	CREBBP EP300	2.32e-04	9	52	2	int:HOXB3
Interaction	ARGFX interactions	CREBBP EP300	2.32e-04	9	52	2	int:ARGFX
Interaction	ETS1 interactions	BPTF ARID1A CREBBP EP300	2.68e-04	121	52	4	int:ETS1
Interaction	ERG interactions	PUF60 MLLT10 ARID1A CREBBP EP300	2.70e-04	223	52	5	int:ERG
Interaction	FOXK2 interactions	MTA2 BPTF PUF60 EP300 CUX1	2.81e-04	225	52	5	int:FOXK2
Interaction	PAX7 interactions	SIX4 ARID1A CREBBP EP300	2.94e-04	124	52	4	int:PAX7
Interaction	SMARCB1 interactions	MTA2 MLLT10 ARID1A CREBBP EP300 CCDC33	3.37e-04	364	52	6	int:SMARCB1
Interaction	ANAPC2 interactions	TOMM22 NCKAP5L CREBBP EP300 CUX1	3.37e-04	234	52	5	int:ANAPC2
Interaction	PAX6 interactions	BPTF SIX4 ARID1A CREBBP EP300 CUX1	3.47e-04	366	52	6	int:PAX6
Interaction	TLE3 interactions	SIX4 MLLT10 ARID1A CREBBP EP300 CUX1	4.00e-04	376	52	6	int:TLE3
Interaction	HLA-DQA1 interactions	LMAN2L PNPLA6 ITGA7 CUX1	4.06e-04	135	52	4	int:HLA-DQA1
Interaction	CFH interactions	PUF60 SYNE2 NCKAP5L EP300	4.66e-04	140	52	4	int:CFH
Interaction	SOX15 interactions	SIX4 ARID1A EP300 CUX1	4.79e-04	141	52	4	int:SOX15
Interaction	FOXQ1 interactions	PUF60 PUM1 CREBBP CUX1	4.79e-04	141	52	4	int:FOXQ1
Interaction	HOXB6 interactions	ANKRD17 CREBBP EP300	5.00e-04	60	52	3	int:HOXB6
Interaction	CUX2 interactions	CUX2 CUX1	5.00e-04	13	52	2	int:CUX2
Interaction	ABCC9 interactions	HMCN2 EP300	5.00e-04	13	52	2	int:ABCC9
Interaction	FHL2 interactions	SP2 PUF60 ANKRD17 ITGA7 CREBBP EP300	5.26e-04	396	52	6	int:FHL2
Interaction	SIRT7 interactions	MTA2 BPTF PUF60 SYNE2 DDX54 ANKRD17 ARID1A PUM1	5.93e-04	744	52	8	int:SIRT7
Interaction	CDC25A interactions	MTA2 CREBBP EP300 CUX1	6.20e-04	151	52	4	int:CDC25A
Interaction	RBBP4 interactions	MTA2 BPTF MIB1 ARID1A CREBBP EP300 CUX1	6.39e-04	573	52	7	int:RBBP4
Interaction	IGFALS interactions	IGFALS ARID1A	6.71e-04	15	52	2	int:IGFALS
Interaction	KLF2 interactions	CREBBP EP300	6.71e-04	15	52	2	int:KLF2
Interaction	HNF4A interactions	BPTF ARID1A CREBBP EP300 CUX1	7.02e-04	275	52	5	int:HNF4A
Interaction	KIAA0753 interactions	CCDC14 MIB1 TPGS1 PUM1	7.17e-04	157	52	4	int:KIAA0753
Interaction	GCM1 interactions	ARID1A CREBBP EP300	7.21e-04	68	52	3	int:GCM1
Cytoband	4q13.3	ENAM ANKRD17	1.05e-03	42	52	2	4q13.3
GeneFamily	CUT class homeoboxes and pseudogenes	ONECUT2 CUX2 CUX1	5.06e-07	9	34	3	527
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	MIB1 CREBBP EP300	4.86e-06	18	34	3	91
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR2 RYR3	1.03e-05	3	34	2	287
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	CREBBP EP300	4.59e-04	17	34	2	486
GeneFamily	EF-hand domain containing	CRNN RYR2 RYR3	7.96e-03	219	34	3	863
GeneFamily	PHD finger proteins	BPTF MLLT10	1.24e-02	90	34	2	88
Coexpression	NABA_CORE_MATRISOME	VWA5B2 COL4A3 IGFALS HMCN2 OTOGL LAMA2 EGFLAM	1.03e-06	270	52	7	MM17057
Coexpression	NABA_ECM_GLYCOPROTEINS	VWA5B2 IGFALS HMCN2 OTOGL LAMA2 EGFLAM	2.13e-06	191	52	6	MM17059
Coexpression	NABA_CORE_MATRISOME	VWA5B2 COL4A3 IGFALS HMCN2 LAMA2 EGFLAM	1.72e-05	275	52	6	M5884
Coexpression	MENON_FETAL_KIDNEY_0_CAP_MESENCHYME_CELLS	CCDC14 BPTF SYNE2 CUX1	3.10e-05	90	52	4	M39250
Coexpression	NABA_ECM_GLYCOPROTEINS	VWA5B2 IGFALS HMCN2 LAMA2 EGFLAM	4.34e-05	196	52	5	M3008
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 FOLH1 OTOGL PKHD1L1 CADM2 RYR2 RYR3	1.95e-09	184	52	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 FOLH1 OTOGL PKHD1L1 CADM2 RYR2 RYR3	1.95e-09	184	52	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 FOLH1 OTOGL PKHD1L1 CADM2 RYR2 RYR3	1.95e-09	184	52	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNTNAP2 LAMA2 PKHD1L1 CADM2 RYR2 RYR3	3.27e-08	160	52	6	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNTNAP2 LAMA2 PKHD1L1 CADM2 RYR2 RYR3	3.27e-08	160	52	6	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	CUX2 CNTNAP2 EGFLAM CADM2 RYR2	1.33e-06	163	52	5	19c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOGL CNTNAP2 PKHD1L1 RYR2 RYR3	1.59e-06	169	52	5	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 OTOGL PKHD1L1 RYR2 RYR3	1.78e-06	173	52	5	66f37c1437705734b20601656fa4aa1d92ca30be
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 OTOGL PKHD1L1 RYR2 RYR3	1.78e-06	173	52	5	649b08a409095592cccf31883be69c754411280d
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_LINC00507_CTXN3\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ONECUT2 CUX2 LAMA2 MAML2 ITGA7	1.99e-06	177	52	5	96d639407f79669f3990138793d157b94273581c
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 GPC4 LAMA2 EGFLAM CCDC33	2.47e-06	185	52	5	4e40d3103ebf4a7066b7ce300b6ef700ba0e2863
ToppCell	COVID-19-kidney-Mito-rich_Int\|kidney / Disease (COVID-19 only), tissue and cell type	CUX2 CNTNAP2 LAMA2 CADM2	1.57e-05	129	52	4	57b705106aec7bbfc587de1ccd4f2335fc44dd6f
ToppCell	Posterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	HMCN2 OTOGL LAMA2 EGFLAM	1.88e-05	135	52	4	e908aacb72a8c340f06cf5b4a6b70c2faac4d027
ToppCell	COVID-19-kidney-Technical/muscle_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	CUX2 CNTNAP2 CADM2 RYR2	2.55e-05	146	52	4	c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCell	COVID-19-Heart-Adipocyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	HMCN2 ITGA7 CADM2 RYR3	3.07e-05	153	52	4	93958bd9c951222ba5b740d1cb83fd5d78a10e1e
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPC4 LAMA2 ITGA7 RYR2	3.31e-05	156	52	4	6365b69ede98bc866e996bc52736b00401aacf6f
ToppCell	facs-Heart-RV-24m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IGFALS CRNN ITGA7 MCRIP2	3.48e-05	158	52	4	2ef43d14ee65d004dc62c12ff209bbe12e4db681
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	CUX2 CNTNAP2 CADM2 RYR2	3.56e-05	159	52	4	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 OTOGL GPC4 PKHD1L1	3.65e-05	160	52	4	bb1b966fb9e801db15e67d03e49db4609d6f935a
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 OTOGL GPC4 PKHD1L1	3.65e-05	160	52	4	56e6f4b82b5dc41c45f9d253c2db314a6f702b84
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CNTNAP2 EGFLAM ST6GALNAC2 CADM2	3.74e-05	161	52	4	7d1bc73f4c82465b3f489d6737048b0cd54f22cf
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CNTNAP2 EGFLAM ST6GALNAC2 CADM2	3.74e-05	161	52	4	410eef62c83c704cbfc5a1b643c4db11bbdcd81f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Neural\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CNTNAP2 EGFLAM ST6GALNAC2 CADM2	3.74e-05	161	52	4	71022485da6754a2b57b4c3e758e3de4c95cc292
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ONECUT2 CUX2 LAMA2 CUX1	3.74e-05	161	52	4	ad9df577fea05d9d4924076d39e1454ddcfc5bab
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CNTNAP2 EGFLAM ST6GALNAC2 CADM2	3.74e-05	161	52	4	59ae8a7c9a04ecaa335b8064852a5a91a21780bd
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 OTOGL GPC4 PKHD1L1	3.74e-05	161	52	4	60f433eab9d5531bdf6aa86b0265f20b866b904c
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ONECUT2 CUX2 LAMA2 CUX1	3.93e-05	163	52	4	0a62ab956d30e5a055afdf59d5b29ca64782f2b6
ToppCell	ICU-SEP-Lymphocyte-B-Plasmablast\|ICU-SEP / Disease, Lineage and Cell Type	COL4A3 ENAM PKHD1L1 CADM2	4.21e-05	166	52	4	98ce43e14133418f676f1c88c001add9e28259a7
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_HSPB3\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ONECUT2 CUX2 OTOGL LAMA2	4.62e-05	170	52	4	985c6c9e3c593ed0628a481f06c2c91b2ab5d746
ToppCell	Control-Fibroblasts-Pericytes\|Control / group, cell type (main and fine annotations)	LAMA2 EGFLAM ITGA7 RYR2	4.73e-05	171	52	4	080003f698f867935c2bfc55d241d3650f45a0ab
ToppCell	COVID-19-Heart-T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CUX2 CNTNAP2 CADM2 RYR3	4.73e-05	171	52	4	b2e753e811a7639956994609f73efcdb62d04f82
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_THEMIS_PLA2G7\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ONECUT2 CUX2 LAMA2 ITGA7	4.84e-05	172	52	4	1d086e00cd549459d70e1d3b468d5ab6379f3bee
ToppCell	facs-Marrow-B-cells-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNTNAP2 LAMA2 CADM2 RYR2	5.18e-05	175	52	4	887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CUX2 OTOGL LAMA2 CUX1	5.41e-05	177	52	4	f902600c639087664316b3cf30cab243bc3d1c5c
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ONECUT2 CUX2 LAMA2 CUX1	5.53e-05	178	52	4	674ee5095b98929c29e4f6bd56029a336cc4a38c
ToppCell	10x3'2.3-week_12-13-Mesenchymal_osteo-stroma-early_osteoblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	COL4A3 FOLH1 GPC4 EGFLAM	5.53e-05	178	52	4	e32f5ed7a492edfa7073416008b1fcfae6b854ad
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC14 ONECUT2 EGFLAM ITGA7	5.65e-05	179	52	4	b44e2d53b82c3c141bfc6539054b19708200a0d9
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPC4 LAMA2 EGFLAM RYR2	5.65e-05	179	52	4	fa03ec3cc0132f977b4cb28e7b23789732375183
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-pericyte_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPC4 LAMA2 EGFLAM RYR2	5.65e-05	179	52	4	f5bb4d3a27d56698473219970e764084096cc582
ToppCell	droplet-Lung-nan-18m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC4 LAMA2 EGFLAM RYR2	5.77e-05	180	52	4	f6a05b3751b01e74b2de8440801b0eb2e723c199
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ONECUT2 CUX2 LAMA2 CUX1	5.77e-05	180	52	4	5391d23817f5cc88a0871ddb98968897c839f464
ToppCell	droplet-Lung-nan-18m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC4 LAMA2 EGFLAM RYR2	5.77e-05	180	52	4	dfc75ae4395ff46fbec2c54915d98ead5a1ba1a1
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWA5B2 ONECUT2 PKHD1L1 CADM2	5.77e-05	180	52	4	6b1606238417490e0d9930870a7827419d1c3737
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	CUX2 CNTNAP2 CUX1 RYR2	5.90e-05	181	52	4	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC14 PNPLA6 PKHD1L1 RYR3	6.16e-05	183	52	4	919c9861073d12fd12aecd7469b1478b13838c43
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENAM FOLH1 LAMA2 PKHD1L1	6.16e-05	183	52	4	ebe369dc80c4fbf8f4dbe947147f8c47507ffb60
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ONECUT2 CUX2 LAMA2 CUX1	6.29e-05	184	52	4	6475a43201b136dcc9b113d2ca4cfa154ed9d65d
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPC4 LAMA2 EGFLAM RYR2	6.29e-05	184	52	4	327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L3-4_RORB_RPS3P6\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ONECUT2 CUX2 LAMA2 CUX1	6.42e-05	185	52	4	10da5c2a92bfb3248d3f6f94a0933996326cf590
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMA2 EGFLAM ST6GALNAC2 CADM2	6.56e-05	186	52	4	6f88b68735d0f7c9904eb8413e6007910d556185
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ONECUT2 CUX2 OTOGL LAMA2	6.56e-05	186	52	4	bdbe290f81106a53c8c30a92fbb385597c62b2ac
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_A_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 GPC4 LAMA2 EGFLAM	6.56e-05	186	52	4	16092819e9148dfe64f07c737652b6e533e699f7
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	BPTF ARID1A PUM1 CUX1	6.56e-05	186	52	4	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	BPTF ARID1A PUM1 CUX1	6.56e-05	186	52	4	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	LA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	COL4A3 HMCN2 LAMA2 MAML2	6.69e-05	187	52	4	4ea486991f66c29728d127171a07b81404ec0b78
ToppCell	Primary_Motor_Cortex_(M1)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ONECUT2 LAMA2 MAML2 ITGA7	6.69e-05	187	52	4	892a4d439a0aa90f254dd17e1edce1fdc3619510
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A3 SYNE2 GPC4 MAML2	6.98e-05	189	52	4	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	ONECUT2 CNTNAP2 CADM2 RYR2	7.12e-05	190	52	4	6e92c78799f34b31d098854503c796edb0dc7f80
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A3 SYNE2 GPC4 MAML2	7.27e-05	191	52	4	d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell	facs-Lung-EPCAM-24m-Epithelial-Neuroendocrine\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC14 IGFALS SIX4 CADM2	7.27e-05	191	52	4	501d4f6ad389d9ac5051d4247b9bd3da96f713f9
ToppCell	facs-Lung-EPCAM-24m-Epithelial-lung_neuroendocrine_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC14 IGFALS SIX4 CADM2	7.27e-05	191	52	4	8e06cc61eaff1796c2ce014074029408ba88d561
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	COL4A3 ENAM CNTNAP2 PKHD1L1	7.41e-05	192	52	4	ab7420aeb22620d85c60b33cf372e5168e538cd4
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	SYNE2 ANKRD17 MAML2 CUX1	7.41e-05	192	52	4	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A3 SYNE2 GPC4 MAML2	7.72e-05	194	52	4	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	LA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	COL4A3 HMCN2 LAMA2 MAML2	7.87e-05	195	52	4	a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCell	facs-Thymus-Thymus_Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 GPC4 LAMA2 RYR3	8.03e-05	196	52	4	6bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCell	facs-Thymus-Thymus_Epithelium-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 GPC4 LAMA2 RYR3	8.03e-05	196	52	4	c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HMCN2 LAMA2 ITGA7 RYR2	8.03e-05	196	52	4	1522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HMCN2 LAMA2 ITGA7 RYR2	8.03e-05	196	52	4	1c8294014713684b50885e638668f2ce75f357f0
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	HMCN2 EGFLAM ITGA7 RYR2	8.19e-05	197	52	4	cfb3dc4b401800e33c82cfc3baee69dbbd16ac8c
ToppCell	Tracheal-NucSeq-Stromal-Schwann-Schwann_nonmyelinating\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	OTOGL EGFLAM ST6GALNAC2 CADM2	8.19e-05	197	52	4	5c88a97e8e23a5cd61885acbe1ef339ae6a1e35a
ToppCell	Bronchial-10x5prime-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	HMCN2 EGFLAM ITGA7 RYR2	8.35e-05	198	52	4	dc6d9032c5029527e184ac13b887c0c1f22ef1c0
ToppCell	10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LAMA2 SIX4 ITGA7 CADM2	8.51e-05	199	52	4	e19b296d583f8bad3b66ee998a8153634d6fe09e
ToppCell	10x3'2.3-week_17-19-Mesenchymal_myocytic\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	LAMA2 SIX4 ITGA7 CADM2	8.51e-05	199	52	4	801887db51ac5dc5b068808ff75e3a46643398e9
ToppCell	Control_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2\|Control_saline / Treatment groups by lineage, cell group, cell type	OTOGL GPC4 LAMA2 RYR2	8.68e-05	200	52	4	bc8949eb34482aca166c4602ff6ab876cb4c2c3c
ToppCell	Hippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Kcnj8_(Mural.Rgs5Acta2.Kcnj8)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	COL4A3 HMCN2 EGFLAM	1.65e-04	91	52	3	78e2e65beb15bf1e251974c72fbcfab817492772
ToppCell	Hippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-MURAL_Mural.Rgs5Acta2.Kcnj8_(Mural.Rgs5Acta2.Kcnj8)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	COL4A3 HMCN2 EGFLAM	1.65e-04	91	52	3	f59908093416ca7b3ca27019d71c79acbdea18cb
ToppCell	Hippocampus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	COL4A3 HMCN2 EGFLAM	1.65e-04	91	52	3	104d2ab9fe5cc404388c32fafb34e421c2e138be
ToppCell	LPS_only-Epithelial_alveolar-AT_2-AT1-AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IGFALS SIX4 MCRIP2	3.04e-04	112	52	3	456278fb92dd41820fde8cf27c68fec45e15f972
ToppCell	Posterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-Kcnj8\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	COL4A3 HMCN2 OTOGL	3.12e-04	113	52	3	0651fb7a7e1ea84b8365059e5ed85bf6c082da1a
ToppCell	Posterior_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_2-Kcnj8-MURAL_Mural.Acta2Rgs5.Kcnj8-Abcc9_(Mural.Acta2Rgs5.Kcnj8-Abcc9)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	COL4A3 HMCN2 OTOGL	3.12e-04	113	52	3	0e153efddd061d7510dfc3859cc8b1a7984fa70e
ToppCell	TCGA-Head_and_Esophagus-Solid_Tissue_Normal-Esophagus_normal_tissue-Esophagus_normal_tissue\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	ENAM CUX2 CADM2	3.90e-04	122	52	3	4f091144530ac1e85f7a8296847ec08753156d71
ToppCell	TCGA-Head_and_Esophagus-Solid_Tissue_Normal-Esophagus_normal_tissue\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	ENAM CUX2 CADM2	3.90e-04	122	52	3	9f48ba786d913182021b3e42349fb84934b855b8
ToppCell	COVID-19-kidney-Epithelial_Doublet\|kidney / Disease (COVID-19 only), tissue and cell type	CUX2 CNTNAP2 RYR2	4.09e-04	124	52	3	d6f59ddb9b9df02b5201f23fa5fb78f3fd891ee9
ToppCell	Control-Lymphocytic_NKT-T_cells-Erythroid\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NABP1 CCDC88B CCDC33	4.29e-04	126	52	3	f582c3ed43209dca3538e60062b3edd59bf2ad6b
ToppCell	TCGA-Head_and_Esophagus-Solid_Tissue_Normal-Esophagus_normal_tissue-Esophagus_normal_tissue-2\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	ENAM CUX2 CADM2	4.70e-04	130	52	3	3450b9edc7360f8494b5e2ded3132c508bbc971b
ToppCell	COVID-19-kidney-Epithelial_(EC)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CUX2 CNTNAP2 RYR3	5.02e-04	133	52	3	a8abb6b54862123961ae6defbf251ee6e9575258
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Gpr139\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	HMCN2 ITGA7 CCDC88B	5.13e-04	134	52	3	917b8951dd4c870b6b92f2e73e02dac884330c30
ToppCell	RA-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	OTOGL CADM2 RYR2	5.24e-04	135	52	3	6121b1d30d05b7d476661b932f51191da09dfeeb
ToppCell	(08)_Brush+PNEC-(2)_GFP_FOXI1\|(08)_Brush+PNEC / shred by cell type by condition	BPTF SYNE2 ANKRD17	5.59e-04	138	52	3	817e3f639604ea95adae01e8685ffaa2e0aff7a8
ToppCell	metastatic_Lymph_Node-Fibroblasts-COL13A1+_matrix_FBs\|Fibroblasts / Location, Cell class and cell subclass	TOMM22 EGFLAM CREBBP	6.07e-04	142	52	3	0e0f8bb956ff89dc98e8fa56f8acac33e01a26dd
ToppCell	Control-Myeloid-Dendritic_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CUX2 CCDC88B CCDC33	6.20e-04	143	52	3	bb8d4c335682d1a6798bed0de8bb0603054a4944
ToppCell	Control-Myeloid-Dendritic_cells-pDC\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CUX2 CCDC88B CCDC33	6.45e-04	145	52	3	bab85a72142b6257f7d424e5301f65b6dcdf745d
ToppCell	COVID-19-kidney-Technical/muscle\|kidney / Disease (COVID-19 only), tissue and cell type	CNTNAP2 CADM2 RYR2	6.85e-04	148	52	3	0dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CUX2 CNTNAP2 CADM2	6.85e-04	148	52	3	d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ENAM CNTNAP2 CADM2	6.98e-04	149	52	3	4b44108c40376a6b73258df40d2424e68f991383
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CUX2 CNTNAP2 CADM2	7.12e-04	150	52	3	0205318a870e091add66ee4305747dda9f51510d
ToppCell	Transplant_Alveoli_and_parenchyma-Immune-B_cells\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	COL4A3 ENAM PKHD1L1	7.40e-04	152	52	3	66f9190de155251a63a7a669374f342a75d22ea0
ToppCell	VE-CD8-memory_CD4\|VE / Condition, Cell_class and T cell subcluster	COL4A3 SYNE2 RYR3	7.40e-04	152	52	3	9401b7770c1bdc87eba25e82922f5dd1c4fa37ee
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HMCN2 ST6GALNAC2 CADM2	7.69e-04	154	52	3	30cb4bb297fa815adb829f3b5cafca56fcbcb810
Drug	2-hydroxycarbazole	RYR2 RYR3	1.53e-05	3	52	2	CID000093551
Drug	cis-diammineplatinum(II	RYR2 RYR3	1.53e-05	3	52	2	CID000159790
Drug	2-hydroxyheptanoic acid	RYR2 RYR3	1.53e-05	3	52	2	CID002750949
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR2 RYR3	1.53e-05	3	52	2	CID005748312
Drug	8N3-cADPR	RYR2 RYR3	1.53e-05	3	52	2	CID000127713
Drug	aminodantrolene	RYR2 RYR3	1.53e-05	3	52	2	CID009570289
Drug	MW 1	FOLH1 CREBBP EP300 RYR2 RYR3	2.43e-05	151	52	5	CID000073965
Drug	rhenium sulfide	CUX2 CUX1	3.06e-05	4	52	2	CID000159414
Drug	PCB74	RYR2 RYR3	3.06e-05	4	52	2	CID000036218
Drug	148504-47-6	RYR2 RYR3	3.06e-05	4	52	2	CID006444275
Drug	SC 38249	RYR2 RYR3	3.06e-05	4	52	2	CID000134834
Drug	AC1L1U7A	RYR2 RYR3	3.06e-05	4	52	2	CID000035682
Drug	LOPAC	FOLH1 RYR2 RYR3	4.37e-05	30	52	3	CID000062696
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	MTA2 BPTF ARID1A CREBBP EP300	4.65e-05	173	52	5	2881_DN
Drug	dimethylphenylphosphine	CUX2 CUX1	5.09e-05	5	52	2	CID000069597
Drug	3,4-dimethoxy-N-((2,2-dimethyl-2H-chromen-6-yl)methyl)-N-phenylbenzenesulfonamide	CREBBP EP300	5.09e-05	5	52	2	ctd:C575894
Drug	SAHA; Down 200; 10uM; PC3; HT_HG-U133A	MTA2 ARID1A CREBBP EP300 ST6GALNAC2	5.33e-05	178	52	5	4444_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	BPTF MLLT10 ARID1A CREBBP EP300	5.62e-05	180	52	5	3688_DN
Drug	MBED	RYR2 RYR3	7.63e-05	6	52	2	CID000129958
Drug	chloro-m-cresol	RYR2 RYR3	7.63e-05	6	52	2	CID000012008
Drug	AC1O528X	RYR2 RYR3	7.63e-05	6	52	2	CID006475857
Drug	NSC114784	RYR2 RYR3	7.63e-05	6	52	2	CID000419425
Drug	PHA-00851261E [724719-49-7]; Down 200; 1uM; PC3; HT_HG-U133A	R3HCC1L TAF1C GPC4 MLLT10 ITGA7	8.21e-05	195	52	5	4333_DN
Drug	Guaifenesin [93-14-1]; Up 200; 20.2uM; MCF7; HT_HG-U133A	MTA2 R3HCC1L TAF1C ZNF236 RYR2	8.61e-05	197	52	5	3431_UP
Drug	Prednisone [53-03-2]; Up 200; 11.2uM; MCF7; HT_HG-U133A	R3HCC1L CNTNAP2 LAMA2 ZNF236 CREBBP	9.03e-05	199	52	5	4400_UP
Drug	Piracetam [7491-74-9]; Down 200; 28.2uM; HL60; HG-U133A	BPTF PNPLA6 TOMM22 DDX54 CUX1	9.25e-05	200	52	5	1710_DN
Drug	Moroxidine hydrochloride [3160-91-6]; Down 200; 19.2uM; HL60; HG-U133A	TAF1C DDX54 ARID1A PUM1 CUX1	9.25e-05	200	52	5	2027_DN
Drug	Azumoleno	RYR2 RYR3	1.07e-04	7	52	2	CID000056259
Drug	covellite	CUX2 CUX1	1.07e-04	7	52	2	CID000014831
Drug	Br2BAPTA	RYR2 RYR3	1.07e-04	7	52	2	CID003081001
Drug	[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate	RYR2 RYR3	1.07e-04	7	52	2	CID009547999
Drug	TCNB	MIB1 LAMA2 RYR2 RYR3	1.58e-04	119	52	4	CID000008330
Drug	ts M	FOLH1 RYR2 RYR3	1.81e-04	48	52	3	CID000428025
Disease	Congenital muscular dystrophy (disorder)	SYNE2 LAMA2 ITGA7	1.03e-07	6	52	3	C0699743
Disease	Menke-Hennekam syndrome	CREBBP EP300	3.05e-06	2	52	2	cv:C5681632
Disease	Rubinstein-Taybi syndrome (implicated_via_orthology)	CREBBP EP300	3.05e-06	2	52	2	DOID:1933 (implicated_via_orthology)
Disease	Rubinstein-Taybi syndrome	CREBBP EP300	3.05e-06	2	52	2	cv:C0035934
Disease	RUBINSTEIN-TAYBI SYNDROME 1	CREBBP EP300	3.05e-06	2	52	2	C4551859
Disease	Muscular dystrophy congenital, merosin negative	LAMA2 ITGA7	3.05e-06	2	52	2	C1263858
Disease	RUBINSTEIN-TAYBI SYNDROME 1	CREBBP EP300	3.05e-06	2	52	2	180849
Disease	Rubinstein-Taybi syndrome due to CREBBP mutations	CREBBP EP300	3.05e-06	2	52	2	cv:C4551859
Disease	Rubinstein-Taybi syndrome (is_implicated_in)	CREBBP EP300	3.05e-06	2	52	2	DOID:1933 (is_implicated_in)
Disease	Rubinstein-Taybi Syndrome	CREBBP EP300	3.05e-06	2	52	2	C0035934
Disease	Bladder Neoplasm	BPTF LAMA2 ARID1A CREBBP EP300	4.86e-06	140	52	5	C0005695
Disease	Malignant neoplasm of urinary bladder	BPTF LAMA2 ARID1A CREBBP EP300	5.03e-06	141	52	5	C0005684
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR2 RYR3	9.13e-06	3	52	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR2 RYR3	9.13e-06	3	52	2	DOID:8545 (implicated_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	ARID1A CREBBP EP300 RYR2 RYR3	2.42e-05	195	52	5	DOID:1574 (implicated_via_orthology)
Disease	Carcinoma, Transitional Cell	ARID1A CREBBP EP300	5.25e-05	41	52	3	C0007138
Disease	Small cell carcinoma of lung	CNTNAP2 CREBBP EP300	1.20e-04	54	52	3	C0149925
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	LMAN2L SYNE2 MLLT10 ARID1A	1.36e-04	148	52	4	C0279702
Disease	Congenital muscular dystrophy	LAMA2 ITGA7	1.99e-04	12	52	2	cv:C0699743
Disease	hematologic cancer (implicated_via_orthology)	CUX2 CUX1	2.35e-04	13	52	2	DOID:2531 (implicated_via_orthology)
Disease	Leukemia, Myelocytic, Acute	MLLT10 CREBBP EP300 CUX1	2.48e-04	173	52	4	C0023467
Disease	Endometrial Carcinoma	ARID1A EP300 CUX1	2.83e-04	72	52	3	C0476089
Disease	T-Cell Lymphoma	ARID1A EP300	3.60e-04	16	52	2	C0079772
Disease	autism spectrum disorder (is_implicated_in)	CNTNAP2 CADM2	3.60e-04	16	52	2	DOID:0060041 (is_implicated_in)
Disease	metabolic syndrome	BPTF CUX2 MLLT10 ARID1A	4.30e-04	200	52	4	EFO_0000195
Disease	Malignant neoplasm of breast	RAPH1 OTOGL SYNE2 LAMA2 SIX4 ARID1A EP300 CUX1	5.45e-04	1074	52	8	C0006142
Disease	osteoarthritis, hip, osteoarthritis, knee, total joint arthroplasty	MAML2 CUX1	6.26e-04	21	52	2	EFO_0004616, EFO_0010726, EFO_1000786
Disease	Adenoid Cystic Carcinoma	ARID1A CREBBP EP300	7.40e-04	100	52	3	C0010606
Disease	Renal glomerular disease	COL4A3 CREBBP	7.53e-04	23	52	2	C0268731
Disease	Glomerulopathy Assessment	COL4A3 CREBBP	7.53e-04	23	52	2	C4521256
Disease	level of Sphingomyelin (d40:2) in blood serum	SYNE2 ANKRD17	7.53e-04	23	52	2	OBA_2045181
Disease	Sezary Syndrome	ARID1A CREBBP	1.04e-03	27	52	2	C0036920
Disease	Intellectual Disability	BPTF CUX2 LMAN2L PUF60 PUM1	1.13e-03	447	52	5	C3714756
Disease	Bilateral Wilms Tumor	GPC4 ARID1A	1.20e-03	29	52	2	C2930471
Disease	cancer (implicated_via_orthology)	CUX2 ITGA7 ARID1A CUX1	1.28e-03	268	52	4	DOID:162 (implicated_via_orthology)
Disease	level of Sphingomyelin (d38:1) in blood serum	SYNE2 ANKRD17	1.28e-03	30	52	2	OBA_2045180
Disease	Papillary Renal Cell Carcinoma	LMAN2L SYNE2 MLLT10	1.51e-03	128	52	3	C1306837
Disease	Renal Cell Carcinoma	LMAN2L SYNE2 MLLT10	1.51e-03	128	52	3	C0007134
Disease	Sarcomatoid Renal Cell Carcinoma	LMAN2L SYNE2 MLLT10	1.51e-03	128	52	3	C1266043
Disease	Chromophobe Renal Cell Carcinoma	LMAN2L SYNE2 MLLT10	1.51e-03	128	52	3	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	LMAN2L SYNE2 MLLT10	1.51e-03	128	52	3	C1266044
Disease	Tinnitus	KRT78 CNTNAP2 CADM2	1.58e-03	130	52	3	HP_0000360
Disease	irritable bowel syndrome	CNTNAP2 EP300 CADM2	1.61e-03	131	52	3	EFO_0000555
Disease	carbohydrate intake measurement	CUX2 CADM2	1.65e-03	34	52	2	EFO_0010811
Disease	IGF-1 measurement	CUX2 IGFALS SYNE2 ARID1A CCDC33	1.66e-03	488	52	5	EFO_0004627

Protein segments in the cluster

Peptide	Gene	Start	Entry
PGQQIGASGLGLQIQ	EP300	261	Q09472
LNGLLQLNNGTPVTG	EGFLAM	481	Q63HQ2
LRGLLQVLQGQPGGQ	CCDC88B	471	A6NC98
NPLQVGSGAGVQLQV	CCDC33	51	Q8N5R6
AQGLPGLNGLKGQQG	COL4A3	816	Q01955
LNGELGQGVLPVQGQ	CUX1	1006	P39880
PNGGELGLLNSGNLV	CREBBP	46	Q92793
QGGQLGSLEPQALLG	IGFALS	106	P35858
GQPVLGQAQLAGLGQ	ANKRD17	986	O75179
DQLGQAVGQQPGASQ	CUX2	961	O14529
GGNQGLTVVIQGQGQ	BPTF	2286	Q12830
LQQLGLVNGILPQQG	CCDC14	326	Q49A88
VLSQGQQQGAPNAGV	R3HCC1L	116	Q7Z5L2
GQLGLGNNGNQLTPV	RCBTB1	211	Q8NDN9
NLSGVNLPGVLQQGC	RAPH1	1031	Q70E73
PINRNQLSQNRGLGG	MTA2	541	O94776
QQHGGQQSPGLAALQ	ARID1A	171	O14497
LGNLQQLQGPFPAGS	PNPLA6	751	Q8IY17
APGPNTGLGQVQGQL	NCKAP5L	1001	Q9HCH0
VTGNGLANQGNNPEV	GPC4	436	O75487
PVGAELGLQLQNQGQ	HMCN2	2306	Q8NDA2
GGVQRGNILNLNGAG	FOLH1	251	Q04609
QGQQGRQEQQEGPVG	DDX54	606	Q8TDD1
PLGNGLGGLHNAQQS	ONECUT2	231	O95948
LQQQGLSGSQQGLEP	KRT78	146	Q8N1N4
LLLGSGQGPQQVGAG	LMAN2L	31	Q9H0V9
GLGGVQAQRPQQQRQ	LAMA2	16	P24043
GQNRPGVQTQGQATG	CRNN	146	Q9UBG3
EQNGNRNPGGLQIGD	MIB1	236	Q86YT6
LLGPNQNGSEGLAQL	PUM1	311	Q14671
GAGSVGNSQQLRPNL	MAML2	926	Q8IZL2
GLLLQGSQGQFPLTQ	CADM2	16	Q8N3J6
QQVQQQLDGGPAGEG	MCRIP2	106	Q9BUT9
NPGQGQAIRNGVNRN	CNTNAP2	1246	Q9UHC6
QALALPGQQANRTGG	ITGA7	76	Q13683
GLNTGNNPPAQNGIG	ENAM	276	Q9NRM1
PGQGRNNNGLEIGCV	RYR2	1496	Q92736
GGQILTSPNQGFNLN	OTOGL	556	Q3ZCN5
GRGLINPQLQGTASN	NABP1	171	Q96AH0
IALQVNGQQGGGSEP	PUF60	6	Q9UHX1
NGNPQQEDGGLAGIT	SYNE2	6511	Q8WXH0
CVQPLLLGGQGGQLQ	TAF1C	501	Q15572
QGPSGVILNGLNVGN	SIX4	371	Q9UIU6
NGGILNGSRQGPNID	ST6GALNAC2	156	Q9UJ37
GGIIGALPGNQLAIN	MLLT10	896	P55197
LGIAILNGGNAGVQQ	RYR3	3651	Q15413
GNNLLIVQSPGGGQP	SP2	281	Q02086
IQNINPSQGSFGGGQ	PKHD1L1	2001	Q86WI1
QRQILLGPNTGLSGG	TOMM22	116	Q9NS69
PGQQLGQGLDDSGNL	VWA5B2	786	Q8N398
QGNLLAQQLTGEPGL	ZNF236	1401	Q9UL36
NGGAGEPPGQLLLQQ	TPGS1	81	Q6ZTW0