Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunction3',5'-cyclic-AMP phosphodiesterase activity

PDE4A PDE4B PDE4C PDE4D

1.08e-0622724GO:0004115
GeneOntologyMolecularFunction3',5'-cyclic-GMP phosphodiesterase activity

PDE4A PDE4B PDE4C PDE4D

1.56e-0624724GO:0047555
GeneOntologyMolecularFunction3',5'-cyclic-nucleotide phosphodiesterase activity

PDE4A PDE4B PDE4C PDE4D

1.86e-0625724GO:0004114
GeneOntologyMolecularFunctioncAMP binding

PDE4A PDE4B PDE4D HCN4

1.86e-0625724GO:0030552
GeneOntologyMolecularFunctioncyclic-nucleotide phosphodiesterase activity

PDE4A PDE4B PDE4C PDE4D

2.56e-0627724GO:0004112
GeneOntologyMolecularFunctionATP hydrolysis activity

ABCB7 KIF15 ERCC6L ABCA13 CFTR NAIP TOR1A MACF1 ABCC9 DDX28

3.94e-064417210GO:0016887
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

TRPA1 HCN4 CFTR RYR1

5.87e-0633724GO:0005217
GeneOntologyMolecularFunctioncyclic nucleotide binding

PDE4A PDE4B PDE4D HCN4

1.16e-0539724GO:0030551
GeneOntologyMolecularFunctionATP-dependent activity

DNHD1 ABCB7 KIF15 ERCC6L ABCA13 CFTR NAIP TOR1A MACF1 ABCC9 DDX28

1.17e-056147211GO:0140657
GeneOntologyMolecularFunctionABC-type transporter activity

ABCB7 ABCA13 CFTR ABCC9

2.91e-0549724GO:0140359
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

GABRD TRPA1 HCN4 CFTR ABCC9 RYR1

6.94e-05193726GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

GABRD TRPA1 HCN4 CFTR ABCC9 RYR1

7.77e-05197726GO:0022834
GeneOntologyMolecularFunctionphosphoric diester hydrolase activity

PDE4A PDE4B PDE4C PDE4D

4.18e-0497724GO:0008081
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

ABCB7 KIF15 ERCC6L ABCA13 CFTR NAIP TOR1A MACF1 ABCC9 DDX28

4.45e-047757210GO:0017111
GeneOntologyMolecularFunctionprimary active transmembrane transporter activity

ABCB7 ABCA13 CFTR ABCC9 UQCRC1

4.59e-04178725GO:0015399
GeneOntologyMolecularFunctionATPase-coupled inorganic anion transmembrane transporter activity

CFTR ABCC9

5.66e-0410722GO:0043225
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCB7 ABCA13 CFTR ABCC9

6.50e-04109724GO:0042626
GeneOntologyMolecularFunctionpyrophosphatase activity

ABCB7 KIF15 ERCC6L ABCA13 CFTR NAIP TOR1A MACF1 ABCC9 DDX28

8.22e-048397210GO:0016462
GeneOntologyMolecularFunctionRoundabout binding

IGFALS RTN4RL1

8.27e-0412722GO:0048495
GeneOntologyMolecularFunctiondynactin binding

BICDL1 MAPT

8.27e-0412722GO:0034452
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

ABCB7 KIF15 ERCC6L ABCA13 CFTR NAIP TOR1A MACF1 ABCC9 DDX28

8.30e-048407210GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

ABCB7 KIF15 ERCC6L ABCA13 CFTR NAIP TOR1A MACF1 ABCC9 DDX28

8.30e-048407210GO:0016818
GeneOntologyMolecularFunctiongated channel activity

GABRD TRPA1 HCN4 CFTR ABCC9 RYR1

1.29e-03334726GO:0022836
GeneOntologyMolecularFunctionNAD+ nucleotidase, cyclic ADP-ribose generating

TLR10 TLR4

1.49e-0316722GO:0061809
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

TRPA1 HCN4 ABCC9 RYR1

1.65e-03140724GO:0099094
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

TRPA1 RYR1

1.89e-0318722GO:0015278
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

TRPA1 HCN4 ABCC9 RYR1

2.22e-03152724GO:0022843
GeneOntologyMolecularFunctionion channel regulator activity

PDE4B PDE4D CFTR ABCC9

2.80e-03162724GO:0099106
GeneOntologyMolecularFunctiontransmembrane transporter binding

PDE4B PDE4D ABCC9 ACTN1

3.47e-03172724GO:0044325
GeneOntologyMolecularFunctionchannel regulator activity

PDE4B PDE4D CFTR ABCC9

3.61e-03174724GO:0016247
GeneOntologyMolecularFunctiontransporter regulator activity

PDE4B PDE4D CFTR ABCC9

3.84e-03177724GO:0141108
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

TRPA1 HCN4 ABCC9 RYR1

4.24e-03182724GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

TRPA1 HCN4 ABCC9 RYR1

4.41e-03184724GO:0022832
GeneOntologyMolecularFunctiontubulin binding

PDE4B KIF15 MAPT ABRAXAS1 MACF1 RABGAP1

4.44e-03428726GO:0015631
GeneOntologyMolecularFunctioncalcium ion binding

MYOF ITSN2 NUCB1 NUCB2 MACF1 ACTN1 PCDH18 RYR1

5.44e-03749728GO:0005509
GeneOntologyMolecularFunctionligand-gated calcium channel activity

TRPA1 RYR1

5.57e-0331722GO:0099604
GeneOntologyMolecularFunctioncytoskeletal protein binding

BICDL1 PDE4B KIF15 MAPT ABRAXAS1 SYNE1 TOR1A MACF1 RABGAP1 ACTN1

5.88e-0310997210GO:0008092
GeneOntologyMolecularFunctionmonoatomic ion channel activity

GABRD TRPA1 HCN4 CFTR ABCC9 RYR1

6.21e-03459726GO:0005216
GeneOntologyBiologicalProcesscAMP catabolic process

PDE4A PDE4B PDE4C PDE4D

1.79e-089734GO:0006198
GeneOntologyBiologicalProcesscAMP metabolic process

ADCY10 PDE4A PDE4B PDE4C PDE4D

2.43e-0825735GO:0046058
GeneOntologyBiologicalProcesscyclic nucleotide catabolic process

PDE4A PDE4B PDE4C PDE4D

1.41e-0714734GO:0009214
GeneOntologyBiologicalProcesscyclic purine nucleotide metabolic process

ADCY10 PDE4A PDE4B PDE4C PDE4D

4.71e-0744735GO:0052652
GeneOntologyBiologicalProcesscyclic nucleotide metabolic process

ADCY10 PDE4A PDE4B PDE4C PDE4D

5.29e-0745735GO:0009187
GeneOntologyBiologicalProcesscAMP-mediated signaling

PDE4A PDE4B PDE4C PDE4D NUCB2

7.34e-0676735GO:0019933
GeneOntologyBiologicalProcessnegative regulation of relaxation of cardiac muscle

PDE4B PDE4D

1.24e-052732GO:1901898
GeneOntologyBiologicalProcessregulation of cardiac muscle cell contraction

ADCY10 PDE4B PDE4D HCN4

1.61e-0543734GO:0086004
GeneOntologyBiologicalProcesscardiac muscle cell contraction

ADCY10 PDE4B PDE4D HCN4 ABCC9

1.97e-0593735GO:0086003
GeneOntologyBiologicalProcessregulation of actin filament-based movement

ADCY10 PDE4B PDE4D HCN4

3.71e-0553734GO:1903115
GeneOntologyBiologicalProcesspositive regulation of monoatomic anion transport

TRPA1 CFTR

7.38e-054732GO:1903793
GeneOntologyBiologicalProcessmuscle contraction

ADCY10 MYOF PDE4B PDE4D TRPA1 HCN4 ABCC9 RYR1

8.34e-05400738GO:0006936
GeneOntologyBiologicalProcessactin-mediated cell contraction

ADCY10 PDE4B PDE4D HCN4 ABCC9

8.79e-05127735GO:0070252
GeneOntologyBiologicalProcessregulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

PDE4A PDE4B PDE4D

1.04e-0426733GO:0106070
GeneOntologyBiologicalProcessstriated muscle contraction

ADCY10 PDE4B PDE4D HCN4 ABCC9 RYR1

1.20e-04217736GO:0006941
GeneOntologyBiologicalProcessresponse to organophosphorus

PDE4D HCN4 CFTR ABCC9 RYR1

1.49e-04142735GO:0046683
GeneOntologyBiologicalProcessreactive oxygen species biosynthetic process

ADCY10 ABCB7 TLR4 ABCC9

1.86e-0480734GO:1903409
GeneOntologyBiologicalProcessactin filament-based movement

ADCY10 PDE4B PDE4D HCN4 ABCC9

2.11e-04153735GO:0030048
GeneOntologyBiologicalProcessnegative regulation of relaxation of muscle

PDE4B PDE4D

2.56e-047732GO:1901078
GeneOntologyBiologicalProcessregulation of cardiac muscle contraction

ADCY10 PDE4B PDE4D HCN4

2.81e-0489734GO:0055117
GeneOntologyBiologicalProcessresponse to purine-containing compound

PDE4D HCN4 CFTR ABCC9 RYR1

3.07e-04166735GO:0014074
GeneOntologyBiologicalProcesscardiac muscle contraction

ADCY10 PDE4B PDE4D HCN4 ABCC9

3.16e-04167735GO:0060048
GeneOntologyBiologicalProcessregulation of relaxation of cardiac muscle

PDE4B PDE4D

4.38e-049732GO:1901897
GeneOntologyBiologicalProcessreactive oxygen species metabolic process

ADCY10 ABCB7 MAPT TLR4 ABCC9 PREX1

5.77e-04291736GO:0072593
GeneOntologyBiologicalProcessregulation of establishment of protein localization

ADCY10 PDE4C TRPA1 MAPT CFTR KIAA0586 TLR4 UBL4B NUCB1

6.05e-04674739GO:0070201
GeneOntologyCellularComponentperinuclear region of cytoplasm

ADCY10 PDE4A PDE4B PDE4C PDE4D HCN4 ASGR2 SYNE1 CNTRL TLR4 PREX1 RYR1

7.63e-059347212GO:0048471
GeneOntologyCellularComponentmembrane attack complex

C5 C6

2.43e-047722GO:0005579
GeneOntologyCellularComponentmonoatomic ion channel complex

GABRD PDE4B PDE4D HCN4 CFTR ABCC9 RYR1

3.21e-04378727GO:0034702
GeneOntologyCellularComponentmyofibril

PDE4B PDE4D SYNE1 ABCC9 ACTN1 RYR1

3.57e-04273726GO:0030016
GeneOntologyCellularComponenttransmembrane transporter complex

GABRD PDE4B PDE4D HCN4 CFTR ABCC9 UQCRC1 RYR1

4.27e-04523728GO:1902495
GeneOntologyCellularComponentcontractile muscle fiber

PDE4B PDE4D SYNE1 ABCC9 ACTN1 RYR1

4.91e-04290726GO:0043292
GeneOntologyCellularComponentvoltage-gated calcium channel complex

PDE4B PDE4D RYR1

5.35e-0446723GO:0005891
GeneOntologyCellularComponenttransporter complex

GABRD PDE4B PDE4D HCN4 CFTR ABCC9 UQCRC1 RYR1

5.96e-04550728GO:1990351
GeneOntologyCellularComponentsomatodendritic compartment

ADCY10 GABRD PDE4B SNCAIP HCN4 MAPT SYNE1 CFTR NAIP RTN4RL1 ACTN1 PREX1

9.29e-0412287212GO:0036477
GeneOntologyCellularComponentcentrosome

MYOF BICDL1 PDE4B PDE4D KIF15 CNTRL KIAA0586 ITSN2 RABGAP1

1.27e-03770729GO:0005813
GeneOntologyCellularComponentcation channel complex

PDE4B PDE4D HCN4 ABCC9 RYR1

1.31e-03235725GO:0034703
GeneOntologyCellularComponentsarcomere

PDE4B SYNE1 ABCC9 ACTN1 RYR1

1.68e-03249725GO:0030017
GeneOntologyCellularComponentcalcium channel complex

PDE4B PDE4D RYR1

2.05e-0373723GO:0034704
MousePhenoimpaired neutrophil chemotaxis

PDE4B PDE4D TLR4 PREX1

2.03e-0540574MP:0008720
DomainPDEase

PDE4A PDE4B PDE4C PDE4D

7.12e-0719714IPR023088
DomainPDEase_I

PDE4A PDE4B PDE4C PDE4D

1.09e-0621714PF00233
DomainPDEASE_I

PDE4A PDE4B PDE4C PDE4D

1.09e-0621714PS00126
DomainPDEase_CS

PDE4A PDE4B PDE4C PDE4D

1.09e-0621714IPR023174
DomainCys-rich_flank_reg_C

TLR10 IGFALS LRRN1 TLR4 RTN4RL1 LRRC70

1.18e-0690716IPR000483
DomainLRRCT

TLR10 IGFALS LRRN1 TLR4 RTN4RL1 LRRC70

1.18e-0690716SM00082
Domain-

PDE4A PDE4B PDE4C PDE4D

1.33e-06227141.10.1300.10
DomainPDEase_catalytic_dom

PDE4A PDE4B PDE4C PDE4D

1.61e-0623714IPR002073
DomainHDc

PDE4A PDE4B PDE4C PDE4D

1.92e-0624714SM00471
DomainHD/PDEase_dom

PDE4A PDE4B PDE4C PDE4D

1.92e-0624714IPR003607
Domain-

TLR10 IGFALS LRRN1 CNTRL TLR4 NAIP RTN4RL1 LRRC70 NLRP13

3.42e-063217193.80.10.10
DomainL_dom-like

TLR10 IGFALS LRRN1 CNTRL TLR4 NAIP RTN4RL1 LRRC70 NLRP13

4.07e-06328719IPR032675
DomainLeu-rich_rpt_typical-subtyp

TLR10 IGFALS LRRN1 CNTRL TLR4 RTN4RL1 LRRC70

4.86e-06177717IPR003591
DomainLRR_TYP

TLR10 IGFALS LRRN1 CNTRL TLR4 RTN4RL1 LRRC70

4.86e-06177717SM00369
DomainLeu-rich_rpt

TLR10 IGFALS LRRN1 CNTRL TLR4 RTN4RL1 LRRC70 NLRP13

8.55e-06271718IPR001611
DomainLRR

TLR10 IGFALS LRRN1 CNTRL TLR4 RTN4RL1 LRRC70

1.12e-05201717PS51450
DomainLRR_1

TLR10 IGFALS LRRN1 CNTRL TLR4 RTN4RL1 LRRC70

1.95e-05219717PF00560
DomainABC_tran

ABCB7 ABCA13 CFTR ABCC9

3.29e-0548714PF00005
DomainABC_TRANSPORTER_2

ABCB7 ABCA13 CFTR ABCC9

3.29e-0548714PS50893
DomainABC_TRANSPORTER_1

ABCB7 ABCA13 CFTR ABCC9

3.57e-0549714PS00211
DomainABC_transporter-like

ABCB7 ABCA13 CFTR ABCC9

3.87e-0550714IPR003439
DomainLRR_8

TLR10 IGFALS LRRN1 TLR4 RTN4RL1 LRRC70

4.72e-05171716PF13855
DomainP-loop_NTPase

ADCY10 DNHD1 ABCB7 KIF15 ERCC6L ABCA13 CFTR NAIP TOR1A ABCC9 DDX28 NLRP13

7.68e-058487112IPR027417
DomainFOXP-CC

FOXP4 FOXP2

8.51e-054712PF16159
DomainFOXP-CC

FOXP4 FOXP2

8.51e-054712IPR032354
DomainActinin_actin-bd_CS

SYNE1 MACF1 ACTN1

8.83e-0523713IPR001589
DomainSpectrin

SYNE1 MACF1 ACTN1

8.83e-0523713PF00435
DomainACTININ_2

SYNE1 MACF1 ACTN1

8.83e-0523713PS00020
DomainACTININ_1

SYNE1 MACF1 ACTN1

8.83e-0523713PS00019
DomainABC_membrane

ABCB7 CFTR ABCC9

1.01e-0424713PF00664
Domain-

ADCY10 DNHD1 ABCB7 ERCC6L ABCA13 CFTR NAIP TOR1A ABCC9 DDX28 NLRP13

1.10e-0474671113.40.50.300
DomainToll-like_receptor

TLR10 TLR4

1.41e-045712IPR017241
DomainABC_TM1F

ABCB7 CFTR ABCC9

1.61e-0428713PS50929
DomainABC1_TM_dom

ABCB7 CFTR ABCC9

1.61e-0428713IPR011527
DomainSpectrin_repeat

SYNE1 MACF1 ACTN1

1.79e-0429713IPR002017
DomainAAA+_ATPase

ABCB7 ABCA13 CFTR NAIP ABCC9

2.20e-04144715IPR003593
DomainAAA

ABCB7 ABCA13 CFTR NAIP ABCC9

2.20e-04144715SM00382
DomainSpectrin/alpha-actinin

SYNE1 MACF1 ACTN1

2.41e-0432713IPR018159
DomainSPEC

SYNE1 MACF1 ACTN1

2.41e-0432713SM00150
DomainEF_hand_dom

ITSN2 NUCB1 NUCB2 MACF1 ACTN1 RYR1

2.51e-04232716IPR002048
DomainEF-hand_1

ITSN2 NUCB1 NUCB2 MACF1 ACTN1

2.82e-04152715PF00036
Domain-

ITSN2 NUCB1 NUCB2 MACF1 ACTN1 RYR1

4.71e-042617161.10.238.10
DomainLRRNT

IGFALS LRRN1 RTN4RL1 LRRC70

5.29e-0498714IPR000372
DomainLRRNT

IGFALS LRRN1 RTN4RL1 LRRC70

5.29e-0498714SM00013
DomainEF_Hand_1_Ca_BS

ITSN2 NUCB1 NUCB2 MACF1 ACTN1

5.39e-04175715IPR018247
DomainABC_transporter_CS

ABCB7 CFTR ABCC9

5.43e-0442713IPR017871
DomainEF-hand-dom_pair

ITSN2 NUCB1 NUCB2 MACF1 ACTN1 RYR1

7.75e-04287716IPR011992
DomainEF_HAND_1

ITSN2 NUCB1 NUCB2 MACF1 ACTN1

1.07e-03204715PS00018
DomainEF_HAND_2

ITSN2 NUCB1 NUCB2 MACF1 ACTN1

1.86e-03231715PS50222
DomainCH

SYNE1 MACF1 ACTN1

1.94e-0365713SM00033
DomainCH

SYNE1 MACF1 ACTN1

2.40e-0370713PF00307
Domain-

SYNE1 MACF1 ACTN1

2.50e-03717131.10.418.10
DomainCH

SYNE1 MACF1 ACTN1

2.71e-0373713PS50021
DomainTIR

TLR10 TLR4

2.86e-0321712SM00255
DomainCH-domain

SYNE1 MACF1 ACTN1

2.92e-0375713IPR001715
DomainEFh

ITSN2 NUCB2 MACF1 ACTN1

3.09e-03158714SM00054
DomainTIR

TLR10 TLR4

3.13e-0322712PF01582
DomainNACHT

NAIP NLRP13

3.42e-0323712PS50837
DomainNACHT_NTPase

NAIP NLRP13

3.42e-0323712IPR007111
Domain-

TLR10 TLR4

3.42e-03237123.40.50.10140
DomainTIR

TLR10 TLR4

3.73e-0324712PS50104
PathwayREACTOME_DARPP_32_EVENTS

PDE4A PDE4B PDE4C PDE4D

3.38e-0716544MM14699
PathwayWP_SILDENAFIL_TREATMENT

PDE4A PDE4B PDE4C PDE4D

1.61e-0623544M46455
PathwayREACTOME_DARPP_32_EVENTS

PDE4A PDE4B PDE4C PDE4D

1.93e-0624544M751
PathwayWP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION

ADCY10 PDE4A PDE4B PDE4C PDE4D

2.05e-0655545M39763
PathwayKEGG_ABC_TRANSPORTERS

ABCB7 ABCA13 CFTR ABCC9

2.33e-0544544M11911
PathwayREACTOME_OPIOID_SIGNALLING

PDE4A PDE4B PDE4C PDE4D

1.54e-0471544MM14491
PathwayKEGG_MEDICUS_REFERENCE_COMMON_PATHWAY_OF_COMPLEMENT_CASCADE_MAC_FORMATION

C5 C6

2.99e-047542M47873
PathwayKEGG_PURINE_METABOLISM

ADCY10 PDE4A PDE4B PDE4C PDE4D

3.47e-04159545M14314
PathwayREACTOME_OPIOID_SIGNALLING

PDE4A PDE4B PDE4C PDE4D

3.85e-0490544M6467
PathwayWP_G_PROTEIN_SIGNALING_PATHWAYS

PDE4A PDE4B PDE4C PDE4D

3.85e-0490544MM15882
PathwayBIOCARTA_ALTERNATIVE_PATHWAY

C5 C6

3.97e-048542MM1582
PathwayREACTOME_TERMINAL_PATHWAY_OF_COMPLEMENT

C5 C6

3.97e-048542M27006
PathwayREACTOME_TERMINAL_PATHWAY_OF_COMPLEMENT

C5 C6

3.97e-048542MM14656
PathwayWP_G_PROTEIN_SIGNALING

PDE4A PDE4B PDE4C PDE4D

4.02e-0491544M39426
PathwayWP_PURINE_METABOLISM

ADCY10 PDE4A PDE4B PDE4C PDE4D

4.85e-04171545MM15909
PathwayBIOCARTA_ALTERNATIVE_PATHWAY

C5 C6

5.10e-049542M22072
PathwayBIOCARTA_LECTIN_PATHWAY

C5 C6

7.75e-0411542MM1430
PathwayWP_COMPLEMENTMEDIATED_INFLAMMATION_OF_PULMONARY_ALVEOLUS_IN_COVID19_HYPOTHETICAL_PATHWAY

C5 C6

9.27e-0412542M48316
PathwayBIOCARTA_CLASSIC_PATHWAY

C5 C6

9.27e-0412542MM1368
PathwayBIOCARTA_LECTIN_PATHWAY

C5 C6

1.09e-0313542M4732
PathwayBIOCARTA_CLASSIC_PATHWAY

C5 C6

1.46e-0315542M7146
PathwayWP_CELLS_AND_MOLECULES_INVOLVED_IN_LOCAL_ACUTE_INFLAMMATORY_RESPONSE

C5 C6

1.89e-0317542M39733
PathwayWP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY

C5 C6

1.89e-0317542MM15944
PathwayBIOCARTA_LAIR_PATHWAY

C5 C6

1.89e-0317542M3952
PathwayBIOCARTA_COMP_PATHWAY

C5 C6

1.89e-0317542MM1369
PathwayWP_MYD88_DISTINCT_INPUTOUTPUT_PATHWAY

TLR10 TLR4

2.12e-0318542M39478
Pubmed

The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.

PDE4A PDE4B PDE4C PDE4D CFTR

3.54e-14573533944911
Pubmed

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.

PDE4A PDE4B PDE4C PDE4D

1.79e-1147349371714
Pubmed

Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice.

PDE4A PDE4B PDE4C PDE4D

1.79e-11473434943270
Pubmed

PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.

PDE4A PDE4B PDE4C PDE4D

1.79e-11473432738081
Pubmed

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.

PDE4A PDE4B PDE4C PDE4D

1.79e-1147348413254
Pubmed

Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion.

PDE4A PDE4B PDE4C PDE4D

1.79e-11473422946044
Pubmed

Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.

PDE4A PDE4B PDE4C PDE4D

1.79e-11473433609559
Pubmed

Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine.

PDE4A PDE4B PDE4C PDE4D

1.79e-11473424732776
Pubmed

A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons.

PDE4A PDE4B PDE4C PDE4D

8.91e-1157348586960
Pubmed

Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum.

PDE4A PDE4B PDE4C PDE4D

2.67e-10673418923023
Pubmed

The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).

PDE4A PDE4B PDE4D

8.87e-09373324555506
Pubmed

Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D.

PDE4A PDE4B PDE4D

8.87e-09373317404263
Pubmed

Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.

PDE4A PDE4B PDE4D

8.87e-09373316034090
Pubmed

Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation.

PDE4A PDE4B PDE4D

8.87e-09373315585880
Pubmed

Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect.

PDE4A PDE4B PDE4D

8.87e-09373310213096
Pubmed

Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts.

PDE4A PDE4B PDE4D

8.87e-09373318508768
Pubmed

Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.

PDE4A PDE4B PDE4C PDE4D

1.26e-08137348009369
Pubmed

Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.

PDE4A PDE4B PDE4D

3.54e-08473321670503
Pubmed

Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes.

PDE4A PDE4B PDE4D

3.54e-08473315644445
Pubmed

Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia.

PDE4A PDE4B PDE4D

3.54e-08473311839681
Pubmed

Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.

PDE4A PDE4B PDE4D

8.84e-08573321652625
Pubmed

Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages.

PDE4A PDE4B PDE4D

8.84e-08573328383060
Pubmed

Overview of PDEs and their regulation.

PDE4A PDE4B PDE4C PDE4D

2.18e-072573417307970
Pubmed

Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury.

TLR4 C5 C6

4.93e-07873317536017
Pubmed

Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes.

PDE4A PDE4B PDE4D

3.18e-061473325852085
Pubmed

Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6.

C5 C6

4.35e-0627322808363
Pubmed

Effects of PDE4 gene polymorphisms on efficacy and adverse drug events of ritodrine therapy in preterm labor patients: a prospective observational study.

PDE4B PDE4D

4.35e-06273231324945
Pubmed

Identification of Parkinson's disease candidate genes using CAESAR and screening of MAPT and SNCAIP in South African Parkinson's disease patients.

SNCAIP MAPT

4.35e-06273221344240
Pubmed

Overexpression of phosphodiesterase-4 subtypes involved in surgery-induced neuroinflammation and cognitive dysfunction in mice.

PDE4B PDE4D

4.35e-06273228235598
Pubmed

Control of basal CFTR gene expression by bicarbonate-sensitive adenylyl cyclase in human pulmonary cells.

ADCY10 CFTR

4.35e-06273218209474
Pubmed

TLR-4-mediated innate immunity is reduced in cystic fibrosis airway cells.

CFTR TLR4

4.35e-06273219502387
Pubmed

PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts.

PDE4B PDE4D

4.35e-06273221288894
Pubmed

Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes.

PDE4A PDE4D

4.35e-0627329520403
Pubmed

Neutrophils activated by membrane attack complexes increase the permeability of melanoma blood vessels.

C5 C6

4.35e-06273235960843
Pubmed

Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.

PDE4B PDE4C

4.35e-06273217727341
Pubmed

Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4.

PDE4B PDE4D

4.35e-06273229123207
Pubmed

Calnuc binds to Alzheimer's beta-amyloid precursor protein and affects its biogenesis.

NUCB1 NUCB2

4.35e-06273217348862
Pubmed

Modulation of nucleobindin-1 and nucleobindin-2 by caspases.

NUCB1 NUCB2

4.35e-06273218154733
Pubmed

Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma.

PDE4A PDE4B

4.35e-06273221047676
Pubmed

G Protein binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new class of G(alpha)i-regulatory motifs.

NUCB1 NUCB2

4.35e-06273221653697
Pubmed

Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis.

CFTR TLR4

4.35e-06273221593379
Pubmed

Association of specific language impairment (SLI) to the region of 7q31.

FOXP2 CFTR

4.35e-06273212721956
Pubmed

Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4.

PDE4A PDE4C

4.35e-06273223043089
Pubmed

C5a and toll-like receptor 4 crosstalk in retinal pigment epithelial cells.

TLR4 C5

4.35e-06273226487798
Pubmed

Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.

PDE4B PDE4D

4.35e-06273215003452
Pubmed

PDE4D plays a critical role in the control of airway smooth muscle contraction.

PDE4B PDE4D

4.35e-06273214519662
Pubmed

Toll-like receptor-4 genotype influences the survival of cystic fibrosis mice.

CFTR TLR4

4.35e-06273220522639
Pubmed

Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B).

PDE4B PDE4D

4.35e-06273217700644
Pubmed

Lipopolysaccharide-Induced TRPA1 Upregulation in Trigeminal Neurons is Dependent on TLR4 and Vesicular Exocytosis.

TRPA1 TLR4

4.35e-06273237643860
Pubmed

PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.

PDE4B PDE4D

4.35e-06273217088426
Pubmed

Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse.

PDE4A PDE4B

4.35e-06273211267656
Pubmed

Crystal structure of C5b-6 suggests structural basis for priming assembly of the membrane attack complex.

C5 C6

4.35e-06273222500023
Pubmed

Modifier effect of the Toll-like receptor 4 D299G polymorphism in children with cystic fibrosis.

CFTR TLR4

4.35e-06273216830219
Pubmed

Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice.

CFTR TLR4

4.35e-06273221712022
Pubmed

Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness.

PDE4A PDE4B PDE4D

4.87e-061673328283561
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MYOF LRRN1 CDK13 KIAA0586 MACF1 ZNF407 PREX1 PCDH18

9.24e-0649373815368895
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

FOXP4 PDE4D LRRN1 MAPT CDK13 NUCB2 AGPAT3 NAIP RTN4RL1 MACF1 RABGAP1 UQCRC1 PRDM15

1.21e-051489731328611215
Pubmed

Zinc finger protein 407 overexpression upregulates PPAR target gene expression and improves glucose homeostasis in mice.

ANGPTL4 ZNF407

1.30e-05373227624101
Pubmed

Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues.

FOXP4 FOXP2

1.30e-05373214516685
Pubmed

Leukocyte phosphodiesterase expression after lipopolysaccharide and during sepsis and its relationship with HLA-DR expression.

PDE4A PDE4B

1.30e-05373228356347
Pubmed

Bacterial and host factors implicated in nasal carriage of methicillin-resistant Staphylococcus aureus in mice.

CFTR TLR4

1.30e-05373215731086
Pubmed

Human-specific transcriptional regulation of CNS development genes by FOXP2.

FOXP4 FOXP2

1.30e-05373219907493
Pubmed

TLR2, TLR4 and TLR10 Shape the Cytokine and Chemokine Release of H. pylori-Infected Human DCs.

TLR10 TLR4

1.30e-05373232486097
Pubmed

Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages.

CFTR TLR4

1.30e-05373228883468
Pubmed

Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication.

PDE4A PDE4B

1.30e-05373211114167
Pubmed

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins.

TRPA1 TLR4

1.30e-05373224445575
Pubmed

Transcriptional regulation by FOXP1, FOXP2, and FOXP4 dimerization.

FOXP4 FOXP2

1.30e-05373225027557
Pubmed

Experimental design of complement component 5a-induced acute lung injury (C5a-ALI): a role of CC-chemokine receptor type 5 during immune activation by anaphylatoxin.

TLR4 C5

1.30e-05373225999468
Pubmed

Formation and structure of the C5b-7 complex of the lytic pathway of complement.

C5 C6

1.30e-0537321387399
Pubmed

Association of toll-like receptor 4, 5 and 10 polymorphisms with Helicobacter pylori-positive peptic ulcer disease in a center in Jordan.

TLR10 TLR4

1.30e-05373234420402
Pubmed

Protein-Protein Interaction Among the FoxP Family Members and their Regulation of Two Target Genes, VLDLR and CNTNAP2 in the Zebra Finch Song System.

FOXP4 FOXP2

1.30e-05373228507505
Pubmed

HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.

PDE4A PDE4C PDE4D

2.50e-052773311156964
Pubmed

Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions.

FOXP4 FOXP2

2.60e-05473214701752
Pubmed

TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells.

TRPA1 TLR4

2.60e-05473229057902
Pubmed

Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis.

C5 C6

2.60e-05473225735751
Pubmed

Identification and characterization of T reg-like cells in zebrafish.

FOXP4 FOXP2

2.60e-05473229066577
Pubmed

Inhibition of high-mobility group box 1 protein (HMGB1) enhances bacterial clearance and protects against Pseudomonas Aeruginosa pneumonia in cystic fibrosis.

CFTR TLR4

2.60e-05473222314397
Pubmed

mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module.

PDE4A PDE4D

2.60e-05473211296225
Pubmed

Meat and fiber intake and interaction with pattern recognition receptors (TLR1, TLR2, TLR4, and TLR10) in relation to colorectal cancer in a Danish prospective, case-cohort study.

TLR10 TLR4

2.60e-05473229566186
Pubmed

Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages.

TLR4 C5

2.60e-05473222491257
Pubmed

Prolyl-isomerase Pin1 accumulates in lewy bodies of parkinson disease and facilitates formation of alpha-synuclein inclusions.

SNCAIP MAPT

2.60e-05473216365047
Pubmed

Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases.

PDE4A PDE4B

2.60e-05473223008439
Pubmed

Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity.

PDE4D RYR1

2.60e-05473218268335
Pubmed

Impaired TLR4 and HIF expression in cystic fibrosis bronchial epithelial cells downregulates hemeoxygenase-1 and alters iron homeostasis in vitro.

CFTR TLR4

2.60e-05473225239913
Pubmed

Identification of an essential spinoparabrachial pathway for mechanical itch.

FOXP2 MAPT

4.33e-05573237023756
Pubmed

Predominant role for C5b-9 in renal ischemia/reperfusion injury.

C5 C6

4.33e-05573210811844
Pubmed

Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.

PDE4A PDE4D

4.33e-05573220196770
Pubmed

Toll-like receptor gene polymorphisms confer susceptibility to graft-versus-host disease in allogenic hematopoietic stem cell transplantation.

TLR10 TLR4

4.33e-05573222703024
Pubmed

A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma.

TLR10 TLR4

4.33e-05573219029192
Pubmed

Analyses of associations with asthma in four asthma population samples from Canada and Australia.

TLR10 CFTR TLR4 C5

4.34e-059273419247692
Pubmed

New genetic associations detected in a host response study to hepatitis B vaccine.

TLR10 FOXP4 PDE4C FOXP2 ASGR2 TLR4 MACF1 C5 C6

5.64e-0582473920237496
Pubmed

Generation of mice with a conditional Foxp2 null allele.

FOXP4 FOXP2

6.48e-05673217619227
Pubmed

Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88.

TLR10 TLR4

6.48e-05673215728506
Pubmed

TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.

SYNE1 TOR1A

6.48e-05673218827015
Pubmed

Structural and functional understanding of the toll-like receptors.

TLR10 TLR4

6.48e-05673233576548
Pubmed

Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.

C5 C6

6.48e-05673222832194
Pubmed

Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.

FOXP4 FOXP2

6.48e-05673228591638
Pubmed

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

MYOF SYNE1 ITSN2 MACF1

6.75e-0510373410574462
Pubmed

Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal Progenitors in Developing Cortex.

FOCAD MAPT PCDH18

7.10e-053873330240734
Pubmed

DISC1, PDE4B, and NDE1 at the centrosome and synapse.

PDE4B PDE4D

9.06e-05773218983980
InteractionAKAP6 interactions

PDE4A PDE4D CFTR RYR1

3.44e-0717724int:AKAP6
CytobandEnsembl 112 genes in cytogenetic band chr9q33

CNTRL TLR4 RABGAP1 C5

7.24e-05138734chr9q33
GeneFamilyPhosphodiesterases

PDE4A PDE4B PDE4C PDE4D

7.78e-0724554681
GeneFamilyCD molecules|Toll like receptors

TLR10 TLR4

4.03e-0410552948
GeneFamilyATP binding cassette subfamily C

CFTR ABCC9

6.94e-0413552807
GeneFamilyNLR family

NAIP NLRP13

2.61e-0325552666
GeneFamilyEF-hand domain containing

ITSN2 NUCB1 NUCB2 MACF1

4.41e-03219554863
GeneFamilyComplement system|Sushi domain containing

C5 C6

5.36e-0336552492
CoexpressionGSE3982_MAST_CELL_VS_BCELL_DN

ABCB7 TRPA1 GLDC SYNE1 TOR1A RABGAP1

1.73e-05197726M5437
CoexpressionCUI_TCF21_TARGETS_2_DN

MYOF PDE4B PDE4D SNCAIP FOXP2 MAPT ITSN2 TLR4 KANK4 RTN4RL1 MACF1

2.03e-058547211M1533
CoexpressionCUI_TCF21_TARGETS_2_DN

MYOF PDE4B PDE4D SNCAIP FOXP2 MAPT ITSN2 TLR4 KANK4 RTN4RL1 MACF1

2.90e-058887211MM1018
ToppCellThalamus-Neuronal-Excitatory|Thalamus / BrainAtlas - Mouse McCarroll V32

GABRD FOXP2 HCN4 CFTR RTN4RL1 NDRG3

4.15e-07176726d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
ToppCellLPS_only-Mesenchymal_myocytic-Pericyte|LPS_only / Treatment groups by lineage, cell group, cell type

MYOF MAPT SYNE1 ABCC9 ACTN1 PCDH18

8.76e-072007268c8ef2b19ab5b1bfc0fae6c38a330f464f28e86f
ToppCellLPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_2|LPS_only / Treatment groups by lineage, cell group, cell type

MYOF PDE4C MAPT ABCC9 ACTN1 PCDH18

8.76e-0720072669edc375d85689300d1dbc1217fedc40063ecdcb
ToppCelldroplet-Liver-nan-3m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYOF ERCC6L KIAA0586 C6 RXYLT1

8.76e-06172725f814b6134ad608015765399d54cc1e5e1873ed34
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

PDE4D FOXP2 ABCA13 CFTR C5

1.35e-05188725ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PDE4A MAPT RTN4RL1 ABCC9 PCDH18

1.42e-05190725106862ef44fcaa0971c3ba0147d13eb08015ca77
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PDE4A MAPT RTN4RL1 ABCC9 PCDH18

1.49e-05192725430ef714bf2544d32f3fd96a55af010f79aa9be0
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYOF SNCAIP ABRAXAS1 ABCC9 PCDH18

1.49e-0519272520ede290e01ad574afd122d72b59dbc52c595fad
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PDE4D FOXP2 SYNE1 CFTR ABCC9

1.53e-05193725fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SNCAIP CDK13 SYNE1 MACF1 PARP15

1.53e-051937259337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PDE4D FOXP2 SYNE1 CFTR ABCC9

1.53e-05193725f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

PDE4D ABCA13 SYNE1 MACF1 CFAP46

1.65e-05196725af4cdc61830685a888a1209826c23bcf54a43084
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

PDE4D ABCA13 SYNE1 MACF1 CFAP46

1.65e-051967256d02d494196e3f857d53eea46d9419690d43beca
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SNCAIP CDK13 SYNE1 MACF1 PARP15

1.69e-0519772557ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FOXP2 ABRAXAS1 ZNF521 ACTN1 PCDH18

1.69e-05197725c7b33d64e5cba3a8fc6f2d6aa85ebc83893195de
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / Treatment groups by lineage, cell group, cell type

FOXP2 CFTR ANGPTL4 KANK4 C5

1.69e-051977251a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCellLPS_only-Epithelial_alveolar-AT_2|LPS_only / Treatment groups by lineage, cell group, cell type

FOXP2 CFTR ANGPTL4 KANK4 C5

1.73e-05198725d087e738d69ca9853553fde46d4e7a8906439d32
ToppCellLPS_only-Epithelial_alveolar|LPS_only / Treatment groups by lineage, cell group, cell type

FOXP4 FOXP2 ANGPTL4 KANK4 C5

1.73e-05198725655df75b9692d815c7f6910275e1f684ac63bf62
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CDK13 SYNE1 MACF1 ZNF407 PARP15

1.77e-05199725f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PDE4D SYNE1 CFTR ABCC9 C5

1.77e-051997252dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCellSigmoid-(5)_Dendritic_cell-(51)_cDC1|Sigmoid / shred on region, Cell_type, and subtype

TLR10 GABRD ASGR2 ACTN1 ZNF662

1.81e-052007254ce0a2238c90622e41fd86ac4b7d82adf4af2c3b
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PDE4C MAPT ABCC9 ACTN1 PCDH18

1.81e-05200725d2fcd3bd7c3223875f027eeb48ff621192a5f242
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

MYOF SYNE1 ABCC9 ACTN1 PCDH18

1.81e-05200725f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Pericyte|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MYOF MAPT ABCC9 ACTN1 PCDH18

1.81e-052007254e1e19214aeebbdca004de7faaf4cc9d18498591
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Pericyte-Pericyte_2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MYOF MAPT ABCC9 ACTN1 PCDH18

1.81e-05200725cf883ba5dbe6350b93142d625a52b25ff2a8bb63
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Pericyte|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MYOF SYNE1 ABCC9 ACTN1 PCDH18

1.81e-05200725b22cae282591d8dead9869c2adbb9632615f50f7
ToppCellControl_saline-Mesenchymal_myocytic|Control_saline / Treatment groups by lineage, cell group, cell type

MYOF SYNE1 ABCC9 ACTN1 PCDH18

1.81e-052007255ed4261157cd51109b314818133ac3a0d34ee5fa
ToppCellSigmoid-Dendritic_cell-cDC1|Sigmoid / Region, Cell class and subclass

TLR10 GABRD ASGR2 ACTN1 ZNF662

1.81e-052007253523ec986e8c9e176e08836c974b1de8b56d8b16
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MYOF MAPT ABCC9 ACTN1 PCDH18

1.81e-05200725786f1ae53e60b5ffbf4bfd393d10b802478148b3
ToppCellLPS_anti-TNF-Mesenchymal_myocytic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MYOF SYNE1 ABCC9 ACTN1 PCDH18

1.81e-0520072567dcbd86fbc79fd585d0793f979e4aac100326c9
ToppCellLPS_only-Mesenchymal_myocytic|LPS_only / Treatment groups by lineage, cell group, cell type

MYOF SYNE1 ABCC9 ACTN1 PCDH18

1.81e-052007258bc9923f82bfb836e2f524204c92050edeae8ca5
ToppCellLPS_IL1RA-Mesenchymal_myocytic|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MYOF SYNE1 ABCC9 ACTN1 PCDH18

1.81e-0520072577631c471cc5d453a749784f838cfa6408caf09b
ToppCellLPS-IL1RA-Unknown-Endothelial-Pericyte_2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIF15 ERCC6L ADAM20 PCDH18

5.05e-051257242938a1d62afe1e0a3abba5eb92f07b886cc0accd
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FOXP4 FOXP2 C5 NLRP13

5.88e-051307246434d9106ccb38786dad36fab80163dfc07b6eb7
ToppCellPND01-03-samps-Mesenchymal-Pericyte-pericyte_E|PND01-03-samps / Age Group, Lineage, Cell class and subclass

ERCC6L KANK4 RTN4RL1 PCDH18

6.81e-0513572435928195cf34f055b353562c96f451aef2344d64
ToppCell3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

BICDL1 GLDC SYNE1 MACF1

6.81e-05135724ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCellTCGA-Bile_Duct|World / Sample_Type by Project: Shred V9

IGFALS ASGR2 C5 C6

7.84e-05140724ca8a0ccbc2f501b759864fe9bb06dc8b44b6b31f
ToppCellAT1-AT2_cells-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

ANGPTL4 KANK4 ABCC9 C5

1.16e-04155724010e45ef4b505bf419ea41e4d1619521d1c78319
ToppCellP15-Epithelial-epithelial_progenitor_cell-epi_progenitor|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MYOF CFTR C5 C6

1.28e-04159724a4bfd59c53237964fc24a24de5c1925fdd01db99
ToppCell10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-CMP|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ADCY10 NUCB2 KANK4 ZNF662

1.31e-04160724be46daf3b42591768c83062a3bb4820efbf88bec
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMK+-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ADAM20 SYNE1 ANGPTL4 NUCB2

1.38e-0416272419395bdb282b4a2d88cd33191af12c24a88c3d16
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNHD1 IGFALS NUCB2 C6

1.38e-041627248e0f03fcc25b2ea777e8478fbf771699cf93719c
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNHD1 IGFALS NUCB2 C6

1.38e-04162724e0417f1242edf71934fe62bccc55c4678f7ff4ac
ToppCellDendritic_Cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

PDE4B NAIP PREX1 GASK1A

1.51e-04166724fbeb74b98b58085de323f744b18d4a8f7b22d5d4
ToppCellP07-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CFTR NUCB2 C5 C6

1.51e-04166724021b9344de7957762f81b09a647504b8c8289cf1
ToppCell(0)_Myeloid-(00)_Monocyte-(000)_CD14+_Monocyte|(00)_Monocyte / immune cells in Peripheral Blood (logTPM normalization)

PDE4B ASGR2 NAIP ACTN1

1.55e-041677247d9fd6a7a45c2aa0d5f2e3960ca4c97ee8836ba5
ToppCellsystemic_lupus_erythematosus-flare-Hematopoietic-Progen-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

LRRN1 ADAM20 NUCB2 ZNF662

1.55e-04167724b89ebd4906f52b1fe6b6540ec9339284e7caddd2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SYNE1 NUCB2 PREX1 GASK1A

1.62e-04169724987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCellCOVID-19_Mild-PLT_2|World / Disease Group and Platelet Clusters

DNHD1 MYOF BICDL1 KIAA0586

1.62e-041697246abfdc8b437f19c03b408bedc245059d28c6ba6a
ToppCellP07-Epithelial-epithelial_progenitor_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CFTR NUCB2 C5 C6

1.62e-04169724ec23caecbb0d969307e33e9df8499ddcd1420305
ToppCellP07-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CFTR NUCB2 C5 C6

1.62e-0416972453e863de064d44e1d36e21fb3dbba37ae020f6e9
ToppCellP07-Epithelial-epithelial_progenitor_cell-epi_progenitor|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CFTR NUCB2 C5 C6

1.62e-041697241a47a4892a5e6a69555f5332308503526e5422a7
ToppCellP15-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CFTR NUCB2 C5 C6

1.66e-041707246c0619cbe2f01a6de18da0a137f92bda0cbdf075
ToppCellP03-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CFTR NUCB2 C5 C6

1.66e-041707243fd37e9b377d6485cea1262c31a8507d18a78514
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF521 RTN4RL1 LRRC70 GASK1A

1.66e-041707244848965bc7e9356c6601bb41eeea1553d2eea87e
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination__)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCB7 AGPAT3 RTN4RL1 ACTN1

1.69e-04171724d1e87478d8c0329e662849823f5c7604f20e1b1a
ToppCellfacs-Marrow-T_cells-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LYPD4 PDE4D ABCA13 SYNE1

1.69e-0417172495e87987a2332fa646849fb0de785f1e0b8a07dd
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

BICDL1 SYNE1 MACF1 ZNF407

1.69e-041717242e9a20f8980b78325c52065a9c14ab3656267c05
ToppCellfacs-Marrow-T_cells-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LYPD4 PDE4D ABCA13 SYNE1

1.69e-0417172436657e277aad75c4f157c1726c48e09b5836cf37
ToppCellCOVID-19_Mild-PLT_2|COVID-19_Mild / Disease Group and Platelet Clusters

DNHD1 MYOF BICDL1 KIAA0586

1.77e-04173724d11705e56b6b21eec963ea224717f27680c781ed
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

KIF15 LRRN1 ERCC6L ZNF662

1.77e-0417372420889aa85e36ad3bafdb91b91e43964493c949f9
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l44|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CNTRL RTN4RL1 DDX28 RYR1

1.77e-04173724b6bb2a136a40f0946bbcde8d5972d3f059d080c7
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

KIF15 LRRN1 ERCC6L ZNF662

1.77e-0417372446e601b7938b1dd0aa3df7aa056c4bd07b1620c1
ToppCellP03-Epithelial-epithelial_progenitor_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CFTR NUCB2 C5 C6

1.81e-0417472423c7fdfc73170cfc5cdee5bb7fbee0c8bbbbca07
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macrophage_intermediate|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TLR10 NAIP RDH13

1.83e-0468723f1cbc6d72489272c1eb6200f64b8b6444719acda
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAPT RTN4RL1 ABCC9 PCDH18

1.85e-04175724fa16c6ba08dc0cc22e8cf049db0577811d080df6
ToppCellP03-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CFTR NUCB2 C5 C6

1.85e-04175724a6d9ca35d3c4b4e3889d0a69b514f63ae630da6b
ToppCellPND01-03-samps-Epithelial-Alveolar_epithelial-AT2|PND01-03-samps / Age Group, Lineage, Cell class and subclass

CFTR NUCB2 AGPAT3 C6

1.89e-04176724ac76f2cd6c63f30b38b89b58bad2baa4dde8ce3a
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYOF FOXP2 SYNE1 PCDH18

1.98e-041787240fb36679cddc9ed8f4b5b34e174d5133c2ea1c76
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERCC6L ABCA13 CNTRL NUCB2

2.02e-04179724d15182c668d7c37be8214cad9f1fe35d1409c9a1
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ERCC6L ABCA13 CNTRL NUCB2

2.02e-04179724e22a275a7c0ed19113c833a75d6c49fcc19aa13a
ToppCellFF-Differ-KC|World / shred by cell class for mouse tongue

SNCAIP GLDC RTN4RL1 RYR1

2.02e-041797241526a130565a97c291a25a7a988089bffc1515c1
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

PDE4D FOXP2 SYNE1 ABCC9

2.06e-04180724198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MYOF PDE4B FOXP2 ABCC9

2.06e-04180724e8841ef1239f9ee73ac4f4e11faca0742694f368
ToppCellcontrol-Lymphoid-B_cell|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

TLR10 PDE4B PREX1 PARP15

2.11e-04181724e414303bb90e5fe7b667c2acf9a50f8694b90e54
ToppCellLPS_only-Epithelial_alveolar-AT_2-AT2_Progenitor|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FOXP2 CFTR KANK4 C5

2.11e-041817240513b9e6673ff7bf8e72ba123ca3794b65d10170
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFALS GLDC ASGR2 GASK1A

2.15e-04182724770ce9f3f4538d0181a0181543841bc964c68274
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo-neutrophil-myelocyte|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

LRRN1 ABCA13 SYNE1 ACTN1

2.15e-0418272452eac2f892ea7f26731e0b21c578fd2665a1657a
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE4C RTN4RL1 ABCC9 PCDH18

2.15e-04182724ffe500d78a89dc6b4d05bab1664e7f30c94fb8d9
ToppCellNS-control-d_0-4-Lymphoid-B_cell|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TLR10 PDE4B PREX1 PARP15

2.15e-041827244b9b55154a79992112c1c467e8752c3cdbb541d9
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFALS GLDC ASGR2 GASK1A

2.15e-0418272477ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFALS GLDC ASGR2 GASK1A

2.15e-041827244921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

PDE4D FOXP2 CFTR ABCC9

2.20e-041837246847c1252d6bb105524f812658112517fd351eab
ToppCellCOPD-Epithelial-ATII|World / Disease state, Lineage and Cell class

PDE4C SYNE1 CFTR ABCC9

2.20e-041837248e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCellfacs-Liver-Hepatocytes-24m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFALS GLDC ASGR2 GASK1A

2.20e-04183724d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE4C RTN4RL1 ABCC9 PCDH18

2.24e-0418472494748f63947db79a6b4540e3090a63689fdd9452
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE4C RTN4RL1 ABCC9 PCDH18

2.24e-04184724819b277ecced7b415e363c7e7ddbc6f3b2d296de
ToppCellPCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_ILC2_(21)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

BICDL1 PDE4A PREX1 RYR1

2.24e-0418472433db879e629821fb75684e60f8f0749cf9623bdd
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYOF MAPT ABCC9 PCDH18

2.24e-04184724102b6f621a5b551e622f97b12d787c080b052a72
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FOXP2 CFTR KANK4 C5

2.24e-04184724ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYOF MAPT ABCC9 PCDH18

2.24e-04184724327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYOF MAPT ABCC9 PCDH18

2.29e-04185724a7dba7db79275884b2a93d8a16f2e0c739e71370
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYOF FOXP4 FOXP2 C5

2.34e-041867244e94158db52df41d71e67b02b9895a358eebee0f
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRRN1 ABCC9 PCDH18 GASK1A

2.34e-041867247c1807fca590cdccf7f5734460bac228d33964ca
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BICDL1 FOXP2 ABCA13 SYNE1

2.34e-04186724f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABRD PDE4C RTN4RL1 ABCC9

2.38e-04187724dba4924d914a7dcd4901142684ba920c2404860b
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABRD PDE4C RTN4RL1 ABCC9

2.38e-041877249688141beef4f62613d7a810c5872ccb9afc1a71
ToppCellCOPD-Epithelial-ATII|Epithelial / Disease state, Lineage and Cell class

PDE4C PDE4D CFTR ABCC9

2.38e-04187724030af361f8bdcd0aff4ec1922702833325cf74d8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KIF15 CNTRL PREX1 RYR1

2.38e-0418772473931a5ea73799095daff100b5f18853c57c74dc
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYOF MAPT ABCC9 PCDH18

2.38e-04187724a2bf958ea59c359a265bfa437d59315e1920cdd4
Drugtrequinsin

PDE4A PDE4B PDE4C PDE4D CFTR

3.43e-119725ctd:C035964
DrugL-826,141

PDE4A PDE4B PDE4C PDE4D CFTR

3.43e-119725ctd:C459562
DrugPiclamilast

PDE4A PDE4B PDE4C PDE4D

9.19e-114724DB01791
DrugIbudilast

PDE4A PDE4B PDE4C PDE4D

4.58e-105724DB05266
Drug1,7-naphthyridine

PDE4A PDE4B PDE4C PDE4D

4.58e-105724CID000009209
DrugIloprost

PDE4A PDE4B PDE4C PDE4D

3.19e-097724DB01088
DrugKetotifen

PDE4A PDE4B PDE4C PDE4D

3.19e-097724DB00920
DrugDyphylline

PDE4A PDE4B PDE4C PDE4D

6.37e-098724DB00651
DrugNVP ABE171

PDE4A PDE4B PDE4C PDE4D

1.90e-0810724ctd:C451724
Drug4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid

PDE4A PDE4B PDE4D

3.03e-083723DB08299
DrugRoflumilast

PDE4A PDE4B PDE4C PDE4D

1.63e-0716724ctd:C424423
DrugCilomilast

PDE4A PDE4B PDE4C PDE4D

2.72e-0718724ctd:C433247
DrugD-22888

PDE4A PDE4B PDE4D

3.02e-075723CID000197714
DrugAA-2379

PDE4A PDE4B PDE4C PDE4D

5.28e-0721724CID000128390
DrugHWA 153

PDE4A PDE4B PDE4C PDE4D

6.44e-0722724CID000162797
Drugatherosperminine

PDE4A PDE4B PDE4C PDE4D

7.78e-0723724CID000096918
Druggriseolic acid

PDE4A PDE4B PDE4C PDE4D

7.78e-0723724CID000127607
Drugfelodipine

PDE4A PDE4B PDE4C PDE4D TRPA1 CFTR RYR1

1.08e-06169727CID000003333
DrugRo 15-2041

PDE4A PDE4B PDE4C PDE4D

1.30e-0626724CID000132434
Drugdesethyl KBT-3022

PDE4A PDE4B PDE4C PDE4D

1.30e-0626724CID000127736
DrugT-440

PDE4A PDE4B PDE4C PDE4D

1.30e-0626724CID000177965
Drugpapaverine

PDE4A PDE4B PDE4C PDE4D TRPA1 CFTR RYR1

1.41e-06176727CID000004680
DrugKF18280

PDE4A PDE4B PDE4D

1.68e-068723CID003071941
Drugcanola oil

ADCY10 PDE4B PDE4D TLR4 ACTN1 PREX1

2.45e-06122726ctd:C061996
Drugimidazole-4-carboxamide

PDE4A PDE4B PDE4C PDE4D

3.09e-0632724CID000152917
Drugdyphylline

PDE4A PDE4B PDE4C PDE4D

3.51e-0633724CID000003182
DrugAH 21-132

PDE4A PDE4B PDE4C PDE4D

5.61e-0637724CID003035793
DrugRolipram

PDE4A PDE4B PDE4D CFTR

5.61e-0637724ctd:D020889
Drugmilrinone

PDE4A PDE4B PDE4C PDE4D SYNE1 CFTR

8.08e-06150726CID000004197
DrugM 98

PDE4B PDE4D

9.86e-062722CID006420180
DrugV11294 Analogue 5f

PDE4B PDE4D

9.86e-062722CID011214587
DrugV11294 Analogue 5i

PDE4B PDE4D

9.86e-062722CID011376249
DrugV11294 Analogue 5t

PDE4B PDE4D

9.86e-062722CID011226695
DrugV11294 Analogue 5e

PDE4B PDE4D

9.86e-062722CID011443441
DrugV11294 Analogue 5d

PDE4B PDE4D

9.86e-062722CID011283750
DrugV11294 Analogue 5n

PDE4B PDE4D

9.86e-062722CID011238279
Drug3-cyclopentyloxy-4-methoxybenzoic acid

PDE4B PDE4D

9.86e-062722CID002779323
DrugV11294 Analogue 5v

PDE4B PDE4D

9.86e-062722CID011375325
DrugV11294 Analogue 5p

PDE4B PDE4D

9.86e-062722CID011478659
Drug3-cyclopentyloxy-4-methoxybenzaldehyde

PDE4B PDE4D

9.86e-062722CID002735893
DrugV11294 Analogue 5o

PDE4B PDE4D

9.86e-062722CID011249748
DrugV11294 Analogue 5c

PDE4B PDE4D

9.86e-062722CID011179896
DrugV11294 Analogue 5b

PDE4B PDE4D

9.86e-062722CID011443760
DrugCis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid

PDE4B PDE4D

9.86e-062722DB03849
DrugT-2585.HCl

PDE4B PDE4D

9.86e-062722CID006918355
DrugNp-V

PDE4B PDE4D

9.86e-062722CID009999276
DrugV11294 Analogue 5m

PDE4B PDE4D

9.86e-062722CID011477773
Drug(S)-Rolipram

PDE4B PDE4D

9.86e-062722DB03606
Drug1-((5-(1-aminoethyl)-2-(8-methoxy-2-(triflurormethyl)-5-quinolinyl)-4-oxazolyl) carbonyl)-4-((cyclopropylcarbonyl)amino)proline ethyl ester

PDE4B PDE4D

9.86e-062722ctd:C554440
DrugV11294 Analogue 8a

PDE4B PDE4D

9.86e-062722CID011442865
DrugV11294 Analogue 5r

PDE4B PDE4D

9.86e-062722CID011168555
DrugV11294 Analogue 5j

PDE4B PDE4D

9.86e-062722CID011433797
DrugV11294 Analogue 5q

PDE4B PDE4D

9.86e-062722CID011318772
DrugV11294 Analogue 5a

PDE4B PDE4D

9.86e-062722CID011386897
DrugV11294 Analogue 5k

PDE4B PDE4D

9.86e-062722CID011456440
DrugV11294 Analogue 5h

PDE4B PDE4D

9.86e-062722CID011306698
Drug3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester

PDE4B PDE4D

9.86e-062722DB01959
Drug4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone

PDE4B PDE4D

9.86e-062722DB01954
Drug(R)-Rolipram

PDE4B PDE4D

9.86e-062722DB04149
Drug(4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one

PDE4A PDE4D

9.86e-062722DB06842
Drugimidazole

PDE4A PDE4B PDE4C PDE4D SYNE1 NUCB1 C5

1.15e-05242727CID000000795
DrugCDP840

PDE4A PDE4B PDE4D

1.65e-0516723CID000127928
DrugAC1LD7MJ

PDE4B PDE4C PDE4D SYNE1

1.75e-0549724CID000643628
DrugOrg 4428

PDE4B PDE4D

2.95e-053722CID000166560
Drug1-Pyrrolidinebutanenitrile

PDE4B PDE4D

2.95e-053722CID000118838
DrugBW A78U

PDE4B PDE4D

2.95e-053722CID000127779
DrugEnprofylline

PDE4A PDE4B

2.95e-053722DB00824
Drugdiquafosol

PDE4B PDE4D CFTR

3.33e-0520723CID000148196
DrugEthisterone [434-03-7]; Down 200; 12.8uM; HL60; HT_HG-U133A

PDE4C NUCB1 AGPAT3 MACF1 RABGAP1 ACTN1

3.37e-051937262366_DN
Drugtrequinsin

PDE4B PDE4C PDE4D CFTR

3.43e-0558724CID000005537
DrugPF-00539758-00 [351321-34-1]; Up 200; 10uM; MCF7; HT_HG-U133A

PDE4C PDE4D ADAM20 CDK13 DDX28 RYR1

3.67e-051967266416_UP
DrugNovobiocin sodium salt [1476-53-5]; Up 200; 6.4uM; MCF7; HT_HG-U133A

GABRD TRPA1 HCN4 MAPT C6 RYR1

3.89e-051987264392_UP
DrugNatamycin [7681-93-8]; Down 200; 6uM; HL60; HT_HG-U133A

MYOF PDE4A PDE4B PDE4D CDK13 ASGR2

4.00e-051997266126_DN
DrugTolazoline hydrochloride [59-97-2]; Up 200; 20.4uM; PC3; HT_HG-U133A

PDE4A IGFALS ABCC9 ZNF407 DDX28 RYR1

4.00e-051997264262_UP
Drugroflumilast

PDE4A PDE4B PDE4D CFTR

4.46e-0562724CID000449193
Drugsiguazodan

PDE4B PDE4C PDE4D

4.47e-0522723CID000072124
Drugvanadyl

PDE4A PDE4B ABCB7 PDE4C PDE4D FOXP2 CFTR

5.27e-05307727CID000061671
Drugdenbufylline

PDE4A PDE4B PDE4D

5.85e-0524723CID000002984
DrugCaffeine

PDE4B RYR1

5.89e-054722DB00201
Drugorthovanadate

PDE4A PDE4B ABCB7 PDE4C PDE4D KIF15 CFTR RYR1

6.84e-05435728CID000061672
Drugzaprinast

PDE4A PDE4B PDE4C PDE4D RYR1

8.51e-05141725CID000005722
DrugAC1O3R20

PDE4A PDE4B PDE4D

9.39e-0528723CID006335051
DrugGonadotropins

CFTR NAIP

9.80e-055722ctd:D006062
DrugJM221

C5 C6

9.80e-055722CID000148147
Drugsalbutamol

ADCY10 PDE4A PDE4B PDE4D NAIP

1.00e-04146725CID000002083
Drugmotapizone

PDE4A PDE4B PDE4D

1.04e-0429723CID000065819
DrugNSC18930

PDE4A PDE4B PDE4C PDE4D

1.04e-0477724CID000001189
DrugDTIC

PDE4A PDE4B PDE4C PDE4D

1.27e-0481724CID005281007
DrugAC1L73CW

PDE4A PDE4B PDE4C PDE4D

1.47e-0484724CID000328776
Drugtalniflumate

PDE4B PDE4D

1.47e-046722CID000048229
Drug4-methylumbelliferyl phenylphosphonate

PDE4B PDE4D

1.47e-046722CID000134928
DrugPentoxifylline

PDE4A PDE4B

1.47e-046722DB00806
Drugibudilast

PDE4A PDE4B PDE4D

1.55e-0433723CID000003671
DrugIBMX

GABRD PDE4A PDE4B PDE4C PDE4D CFTR NAIP

1.63e-04368727CID000003758
Drugzardaverine

PDE4A PDE4B PDE4D

1.85e-0435723CID000005723
DrugP-NE

PDE4A PDE4B PDE4C PDE4D HCN4

1.99e-04169725CID000446755
DrugTheophylline

PDE4A PDE4B

2.05e-047722DB00277
Drugnitraquazone

PDE4B PDE4D

2.05e-047722CID000068765
Drugsildenafil

PDE4A PDE4B PDE4D CFTR

2.45e-0496724CID000005212
DrugRP 73401

PDE4A PDE4B PDE4D

2.55e-0439723CID000154575
Diseasespecific developmental disorder (implicated_via_orthology)

FOXP4 FOXP2

3.22e-054692DOID:0060038 (implicated_via_orthology)
Diseaseprogression free survival, response to carboplatin, methylcobalamin deficiency type cblE, ovarian carcinoma

PDE4B PDE4D FOXP2

1.05e-0439693EFO_0001075, EFO_0004920, GO_0097328, MONDO_0009354
DiseaseParkinson disease, late-onset

SNCAIP MAPT

2.40e-0410692cv:C3160718
DiseasePARKINSON DISEASE, LATE-ONSET

SNCAIP MAPT

2.40e-0410692168600
DiseasePARKINSON DISEASE, LATE-ONSET

SNCAIP MAPT

3.50e-0412692C3160718
Diseasecystic fibrosis (is_marker_for)

CFTR TLR4 C5

4.19e-0462693DOID:1485 (is_marker_for)
Diseasediabetic neuropathy (implicated_via_orthology)

TRPA1 TLR4

4.82e-0414692DOID:9743 (implicated_via_orthology)
Diseaseasthma (is_implicated_in)

TLR10 CFTR TLR4 C5

5.10e-04157694DOID:2841 (is_implicated_in)
DiseaseAsthma

PDE4B PDE4D TRPA1

8.84e-0480693C0004096
Diseaseirritability measurement

FOXP2 MAPT TLR4

9.50e-0482693EFO_0009594
Diseasesnoring measurement

MAPT RTN4RL1 MACF1

1.02e-0384693EFO_0008341
Diseasephysical activity

TLR4 ZNF521 ABCC9

1.16e-0388693EFO_0003940
Diseaseblood pressure

SYNE1 PREX1

1.21e-0322692EFO_0004325
DiseaseParkinson disease

SNCAIP MAPT

1.21e-0322692cv:C0030567
DiseaseBrugada Syndrome (disorder)

HCN4 ABCC9

1.44e-0324692C1142166
Diseasesmoking status measurement

FOCAD PDE4B TBRG4 FOXP2 MAPT TLR4 NUCB2 ZNF521 ZNF407

1.48e-031160699EFO_0006527
Diseaseblood rubidium measurement

ABCA13 PREX1

1.69e-0326692EFO_0021529
Diseaseneurotic disorder

PDE4D MAPT TLR4

1.73e-03101693EFO_0004257
DiseaseDevelopmental Academic Disorder

MAPT TLR4

2.10e-0329692C1330966
DiseaseLearning Disorders

MAPT TLR4

2.10e-0329692C0023186
DiseaseLearning Disturbance

MAPT TLR4

2.10e-0329692C0751263
DiseaseAdult Learning Disorders

MAPT TLR4

2.10e-0329692C0751262
DiseaseLearning Disabilities

MAPT TLR4

2.10e-0329692C0751265

Protein segments in the cluster

PeptideGeneStartEntry
LLHKNLQEHFSNQDL

ABRAXAS1

116

Q6UWZ7
EHQDLGLYHLKQINS

NAIP

766

Q13075
LHAKLKHLQDDNNLL

CNTRL

771

Q7Z7A1
QLENHELQGLKLQHD

CNTRL

1706

Q7Z7A1
DHQLIQEALIFDNKH

ACTN1

691

P12814
EKQHLRIQHLQSQFG

ANGPTL4

131

Q9BY76
RIQHLQSQFGLLDHK

ANGPTL4

136

Q9BY76
NNLNKFDEGLALAHF

CFTR

186

P13569
LQHDVAHLFIKDTQG

ADAM20

291

O43506
QQDLKADHDALLFHL

ASGR2

136

P07307
NHNHHLILAGRQKEL

CFAP46

746

Q8IYW2
KGLFQALDENLHQLH

ABCA13

4126

Q86UQ4
KDLHFLEELQLGHNR

IGFALS

311

P35858
GLTAAKNLHHNLLNK

ABCC9

1061

O60706
HLFFLIGDKQAHKQL

DNHD1

3011

Q96M86
LAHHFLALGENDKAL

ADCY10

1071

Q96PN6
QGHDKDLQLHQSQLE

BICDL1

296

Q6ZP65
LLESGLVHFNENHIK

CDK13

801

Q14004
DLVNLSHLFLHGNKL

RTN4RL1

171

Q86UN2
LHLELEALNGKHQQI

ITSN2

491

Q9NZM3
FDNVLNHLNDGKHEL

PCDH18

1101

Q9HCL0
CKIQDLEHHLGLALN

RABGAP1

1026

Q9Y3P9
AHHFGQEELQANLDL

NDRG3

191

Q9UGV2
IKNDHKNNERLLFHG

PARP15

546

Q460N3
EHFLLHREGKFNNTL

KIR2DS4

56

P43632
LAEENGKLVGHQNLH

KIF15

1336

Q9NS87
VLENHHLAVGFKLLQ

PDE4A

501

P27815
ENHHLAVGFKLLQEE

PDE4B

476

Q07343
VLENHHLAVGFKLLQ

PDE4C

456

Q08493
LENHHLAVGFKLLQE

PDE4D

531

Q08499
GQFLKHLNNEHALDD

FOXP2

361

O15409
ILDDHKIQHLRLQGQ

DDX28

416

Q9NUL7
NQLLADFHHIGSIKV

LYPD4

196

Q6UWN0
EHIHGLDKLQLAQFT

GABRD

201

O14764
LGQFIKHLNTEHALD

FOXP4

321

Q8IVH2
DHQALLKQFDHLNHL

NUCB2

131

P80303
LKQFDHLNHLNPDKF

NUCB2

136

P80303
HLNLLKQFEHLDPQN

NUCB1

131

Q02818
GVEHQQLLDLAQKHL

UQCRC1

236

P31930
LLHKVQHDLNSGVFN

HCN4

721

Q9Y3Q4
NNLKHLILSHNDLEN

LRRC70

276

Q7Z2Q7
HKLEGALLALGQFQH

MACF1

6216

Q9UPN3
NHLGHFLLTNLLLDK

RDH13

146

Q8NBN7
QVLLGHIQKHNLTLF

GASK1A

556

Q9UFP1
EKCLNNQQLHFLHIG

C6

821

P13671
DNHKALLVGEHLNII

C5

471

P01031
HFLKLLVNLADHNGN

KANK4

811

Q5T7N3
QKLQHLAVVLLGNEH

RXYLT1

191

Q9Y2B1
EFLHNNLHLQGKVEG

RYR1

3551

P21817
LAHLLVEDKGQNLHQ

FOCAD

456

Q5VW36
ELHNQLFEHQKEGIA

ERCC6L

91

Q2NKX8
EDKGLLIQDAHFHQL

TBRG4

116

Q969Z0
HAFAGLKNLLRLHLN

LRRN1

161

Q6UXK5
LKFNLLAHLADDLGH

MRPL50

96

Q8N5N7
HLDLSQNLLQHKNDE

TLR10

401

Q9BXR5
SNLDAEILQDHHKQL

SYNE1

8581

Q8NF91
QLLNEHLLGHLEQAK

PRDM15

576

P57071
DKLHGCLEHLFNQVD

PREX1

1216

Q8TCU6
NLDKIHDENGNNLLH

SNCAIP

341

Q9Y6H5
ALHLLANEQLEKGHI

ERVK-9

971

P63128
AKNVFLHLHNLDLGF

ABCB7

226

O75027
LNKQQASFLHLALHN

TRPA1

576

O75762
LQKDLDDNLFGQHLA

TOR1A

61

O14656
GKEHAVIILNHNFEI

AGPAT3

86

Q9NRZ7
ELSGHINLFVDVNKH

THAP9

806

Q9H5L6
DLQLHVKHNHLENQG

ZNF521

766

Q96K83
ELLKHQLLGDLHQEG

MAPT

186

P10636
QHLLFRGQLLEDDKH

UBL4B

41

Q8N7F7
DNLHNRKKHLNGLQH

ZMAT5

16

Q9UDW3
DSEQNLFLHIKGQHE

ZNF407

1496

Q9C0G0
LEQLEHLDFQHSNLK

TLR4

421

O00206
SQNHGDHLVLLKDEL

KIAA0586

11

Q9BVV6
NNLLGIHHKILNEQI

ZNF662

176

Q6ZS27
GHQLQHDLFFDTLKI

GLDC

426

P23378
NALSHNHNVKILDLG

NLRP13

946

Q86W25
SLDEFEANKILHQHL

MYOF

1706

Q9NZM1