Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	GPI-linked ephrin receptor activity	EPHA3 EPHA5	2.17e-04	7	65	2	GO:0005004
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	CAD STK40 TP53RK ALPK2 WNK2 IPMK MAP3K4 EPHA3 EPHA5	4.60e-04	709	65	9	GO:0016773
GeneOntologyMolecularFunction	protein kinase activity	CAD STK40 TP53RK ALPK2 WNK2 MAP3K4 EPHA3 EPHA5	7.09e-04	600	65	8	GO:0004672
GeneOntologyMolecularFunction	kinase activity	CAD STK40 TP53RK ALPK2 WNK2 IPMK MAP3K4 EPHA3 EPHA5	7.86e-04	764	65	9	GO:0016301
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase regulatory subunit binding	PIK3AP1 PTPN13	9.26e-04	14	65	2	GO:0036312
GeneOntologyMolecularFunction	transmembrane-ephrin receptor activity	EPHA3 EPHA5	1.07e-03	15	65	2	GO:0005005
GeneOntologyMolecularFunction	ephrin receptor activity	EPHA3 EPHA5	1.72e-03	19	65	2	GO:0005003
GeneOntologyMolecularFunction	p53 binding	HIF1A PPP1R13B TP53RK	2.03e-03	77	65	3	GO:0002039
GeneOntologyMolecularFunction	calcium ion binding	BMP1 USP6 PPP2R3A PAMR1 PCDHGA9 ACAN TLL2 PCDHGA8	2.88e-03	749	65	8	GO:0005509
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	CAD STK40 TP53RK ALPK2 WNK2 IPMK MAP3K4 EPHA3 EPHA5	3.22e-03	938	65	9	GO:0016772
GeneOntologyBiologicalProcess	cellular response to follicle-stimulating hormone stimulus	FSHR EPHA3 EPHA5	1.32e-05	15	65	3	GO:0071372
GeneOntologyBiologicalProcess	response to follicle-stimulating hormone	FSHR EPHA3 EPHA5	3.81e-05	21	65	3	GO:0032354
GeneOntologyBiologicalProcess	cellular response to gonadotropin stimulus	FSHR EPHA3 EPHA5	4.41e-05	22	65	3	GO:0071371
GeneOntologyBiologicalProcess	heart development	HIF1A CAD DYNC2H1 TMEM94 ACAN MED1 NEB PPP1R13L ALPK2 EPHA3	1.20e-04	757	65	10	GO:0007507
GeneOntologyBiologicalProcess	response to gonadotropin	FSHR EPHA3 EPHA5	1.39e-04	32	65	3	GO:0034698
GeneOntologyBiologicalProcess	somatic muscle development	PPP2R3A NEB	1.45e-04	6	65	2	GO:0007525
Domain	DBB	PIK3AP1 BANK1	1.12e-05	2	63	2	PS51376
Domain	DBB_domain	PIK3AP1 BANK1	1.12e-05	2	63	2	IPR017893
Domain	DBB	PIK3AP1 BANK1	1.12e-05	2	63	2	PF14545
Domain	DBB	PIK3AP1 BANK1	1.12e-05	2	63	2	SM01282
Domain	BMP_1/tolloid-like	BMP1 TLL2	3.35e-05	3	63	2	IPR015446
Domain	Peptidase_M12A	BMP1 TLL2	1.67e-04	6	63	2	IPR001506
Domain	Astacin	BMP1 TLL2	1.67e-04	6	63	2	PF01400
Domain	Kinase-like_dom	PTPN13 STK40 TP53RK ALPK2 WNK2 MAP3K4 EPHA3 EPHA5	4.55e-04	542	63	8	IPR011009
Domain	CUB	BMP1 PAMR1 TLL2	6.03e-04	49	63	3	PF00431
Domain	CUB	BMP1 PAMR1 TLL2	6.40e-04	50	63	3	SM00042
Domain	-	BMP1 PAMR1 TLL2	7.18e-04	52	63	3	2.60.120.290
Domain	CUB	BMP1 PAMR1 TLL2	7.60e-04	53	63	3	PS01180
Domain	CUB_dom	BMP1 PAMR1 TLL2	9.40e-04	57	63	3	IPR000859
Domain	RECEPTOR_TYR_KIN_V_2	EPHA3 EPHA5	9.93e-04	14	63	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHA3 EPHA5	9.93e-04	14	63	2	PS00790
Domain	Eph_TM	EPHA3 EPHA5	9.93e-04	14	63	2	IPR027936
Domain	Tyr_kinase_rcpt_V_CS	EPHA3 EPHA5	9.93e-04	14	63	2	IPR001426
Domain	EPH_lbd	EPHA3 EPHA5	9.93e-04	14	63	2	SM00615
Domain	Ephrin_lbd	EPHA3 EPHA5	9.93e-04	14	63	2	PF01404
Domain	EphA2_TM	EPHA3 EPHA5	9.93e-04	14	63	2	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHA3 EPHA5	9.93e-04	14	63	2	IPR016257
Domain	Ephrin_rcpt_lig-bd_dom	EPHA3 EPHA5	9.93e-04	14	63	2	IPR001090
Domain	EPH_LBD	EPHA3 EPHA5	9.93e-04	14	63	2	PS51550
Domain	Growth_fac_rcpt_	BMP1 FRAS1 EPHA3 EPHA5	1.90e-03	156	63	4	IPR009030
Domain	EGF_2	BMP1 PAMR1 TLL2 EPHA3 EPHA5	1.99e-03	265	63	5	PS01186
Domain	Ephrin_rec_like	EPHA3 EPHA5	3.20e-03	25	63	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHA3 EPHA5	3.20e-03	25	63	2	IPR011641
Domain	ZnMc	BMP1 TLL2	4.29e-03	29	63	2	SM00235
Domain	Peptidase_Metallo	BMP1 TLL2	4.29e-03	29	63	2	IPR006026
Domain	PROTEIN_KINASE_TYR	TP53RK EPHA3 EPHA5	4.30e-03	97	63	3	PS00109
Domain	Tyr_kinase_AS	TP53RK EPHA3 EPHA5	4.30e-03	97	63	3	IPR008266
Domain	PROTEIN_KINASE_ATP	STK40 TP53RK WNK2 MAP3K4 EPHA3 EPHA5	4.44e-03	459	63	6	PS00107
Domain	Prot_kinase_dom	STK40 TP53RK WNK2 MAP3K4 EPHA3 EPHA5	6.02e-03	489	63	6	IPR000719
Domain	PROTEIN_KINASE_DOM	STK40 TP53RK WNK2 MAP3K4 EPHA3 EPHA5	6.25e-03	493	63	6	PS50011
Pubmed	Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression.	HIF1A KDM4C	3.55e-06	2	66	2	23129632
Pubmed	ASPP: a new family of oncogenes and tumour suppressor genes.	PPP1R13B PPP1R13L	1.06e-05	3	66	2	17211478
Pubmed	ASPP--Apoptotic specific regulator of p53.	PPP1R13B PPP1R13L	1.06e-05	3	66	2	16139958
Pubmed	Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP.	PPP1R13B PPP1R13L	1.06e-05	3	66	2	22552744
Pubmed	Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.	BMP1 TLL2	1.06e-05	3	66	2	18824173
Pubmed	EphrinA/EphA-induced ectodomain shedding of neural cell adhesion molecule regulates growth cone repulsion through ADAM10 metalloprotease.	EPHA3 EPHA5	1.06e-05	3	66	2	24117969
Pubmed	Identification of ocular regulatory functions of core histone variant H3.2.	EPHA3 EPHA5	1.06e-05	3	66	2	36529279
Pubmed	A novel all-trans retinoic acid derivative 4-amino‑2‑trifluoromethyl-phenyl retinate inhibits the proliferation of human hepatocellular carcinoma HepG2 cells by inducing G0/G1 cell cycle arrest and apoptosis via upregulation of p53 and ASPP1 and downregulation of iASPP.	PPP1R13B PPP1R13L	1.06e-05	3	66	2	27177208
Pubmed	Genetic analysis of the role of proteolysis in the activation of latent myostatin.	BMP1 TLL2	1.06e-05	3	66	2	18286185
Pubmed	Hypoxia-inducible factor (HIF)-1α and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1α level and transcriptional activity.	HIF1A ACAN	1.06e-05	3	66	2	23530034
Pubmed	Thalamic afferents influence cortical progenitors via ephrin A5-EphA4 interactions.	TBR1 EPHA3 EPHA5	1.12e-05	23	66	3	25480914
Pubmed	Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B" subunits of protein phosphatase 2A.	PPP2R3A PPP2R3C	2.12e-05	4	66	2	18715506
Pubmed	microRNA-216b enhances cisplatin-induced apoptosis in osteosarcoma MG63 and SaOS-2 cells by binding to JMJD2C and regulating the HIF1α/HES1 signaling axis.	HIF1A KDM4C	2.12e-05	4	66	2	32972441
Pubmed	Disruption of ephrin signaling associates with disordered axophilic migration of the gonadotropin-releasing hormone neurons.	EPHA3 EPHA5	2.12e-05	4	66	2	15788771
Pubmed	Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.	HIF1A KDM4C	2.12e-05	4	66	2	18713068
Pubmed	OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase.	USP44 USP6 OTUD6A	3.11e-05	32	66	3	33669244
Pubmed	Compensatory Actions of Ldb Adaptor Proteins During Corticospinal Motor Neuron Differentiation.	TBR1 EPHA3 EPHA5	3.42e-05	33	66	3	26830346
Pubmed	iASPP is essential for HIF-1α stabilization to promote angiogenesis and glycolysis via attenuating VHL-mediated protein degradation.	HIF1A PPP1R13L	3.53e-05	5	66	2	35169254
Pubmed	RAD51 haploinsufficiency causes congenital mirror movements in humans.	TBR1 DCC	3.53e-05	5	66	2	22305526
Pubmed	The ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53.	PPP1R13B PPP1R13L	3.53e-05	5	66	2	21513714
Pubmed	Increases of iASPP-Keap1 interaction mediated by syringin enhance synaptic plasticity and rescue cognitive impairments via stabilizing Nrf2 in Alzheimer's models.	PPP1R13B PPP1R13L	3.53e-05	5	66	2	32828017
Pubmed	The ephrin signaling pathway regulates morphology and adhesion of mouse granulosa cells in vitro.	EPHA3 EPHA5	3.53e-05	5	66	2	23242526
Pubmed	VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.	HIF1A EP400	3.53e-05	5	66	2	18297059
Pubmed	Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.	BMP1 TLL2	3.53e-05	5	66	2	10479448
Pubmed	Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation.	HIF1A IPMK	3.53e-05	5	66	2	29279301
Pubmed	Expression of ephrinA5 during development and potential involvement in the guidance of the mesostriatal pathway.	EPHA3 EPHA5	3.53e-05	5	66	2	19576892
Pubmed	Hypoxia-inducible factor 1alpha inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III collagen in the hypoxia-inducible factor 1alpha-dependent redifferentiation of chondrocytes.	HIF1A ACAN	3.53e-05	5	66	2	19790048
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	FRAS1 EP400 BTBD7 PLCE1	4.54e-05	103	66	4	10819331
Pubmed	Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins.	PPP1R13B PPP1R13L	5.29e-05	6	66	2	23088536
Pubmed	Area specificity and topography of thalamocortical projections are controlled by ephrin/Eph genes.	EPHA3 EPHA5	5.29e-05	6	66	2	12895420
Pubmed	Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif.	PPP1R13B PPP1R13L	5.29e-05	6	66	2	21998301
Pubmed	Opposing gradients of ephrin-As and EphA7 in the superior colliculus are essential for topographic mapping in the mammalian visual system.	EPHA3 EPHA5	5.29e-05	6	66	2	15996548
Pubmed	Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.	HIF1A EPHA3 EPHA5	7.11e-05	42	66	3	11439183
Pubmed	Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage.	CSGALNACT2 ACAN	7.40e-05	7	66	2	17145758
Pubmed	Mouse cartilage matrix deficiency (cmd) caused by a 7 bp deletion in the aggrecan gene.	ACAN ZP2	7.40e-05	7	66	2	7920633
Pubmed	Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolism.	CSGALNACT2 ACAN	7.40e-05	7	66	2	21148564
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	BMP1 FRAS1 CSGALNACT2 METTL9 DIPK1A ACP1 HLA-F NCEH1 KIF2A TMED10	8.45e-05	1201	66	10	35696571
Pubmed	Mistargeting hippocampal axons by expression of a truncated Eph receptor.	EPHA3 EPHA5	9.86e-05	8	66	2	12124402
Pubmed	MEKK4 signaling regulates filamin expression and neuronal migration.	TBR1 MAP3K4	9.86e-05	8	66	2	17145501
Pubmed	The involvement of cytokine-like 1 (Cytl1) in chondrogenesis and cartilage metabolism.	HIF1A ACAN	9.86e-05	8	66	2	32736681
Pubmed	Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model.	HIF1A TBR1	9.86e-05	8	66	2	33510137
Pubmed	Glucose metabolism induced by Bmp signaling is essential for murine skeletal development.	BMP1 HIF1A	9.86e-05	8	66	2	30446646
Pubmed	Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.	RAMP3 TBR1 DCC EPHA5	9.95e-05	126	66	4	16284245
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FRAS1 EP400 TMEM94 BTBD7 MAP3K4 PLCE1	1.24e-04	407	66	6	12693553
Pubmed	The Metabolite Saccharopine Impairs Neuronal Development by Inhibiting the Neurotrophic Function of Glucose-6-Phosphate Isomerase.	AASS TBR1	1.27e-04	9	66	2	35135854
Pubmed	Degenerate PCR-based cloning method for Eph receptors and analysis of their expression in the developing murine central nervous system and vasculature.	EPHA3 EPHA5	1.27e-04	9	66	2	11403717
Pubmed	Topographic guidance labels in a sensory projection to the forebrain.	EPHA3 EPHA5	1.27e-04	9	66	2	9883724
Pubmed	Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression.	HIF1A CAD	1.27e-04	9	66	2	28775317
Pubmed	A screen for downstream effectors of Neurogenin2 in the embryonic neocortex.	ARHGAP5 DCC EPHA5	1.35e-04	52	66	3	15328020
Pubmed	Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate.	EPHA3 EPHA5	1.58e-04	10	66	2	25073978
Pubmed	Quantitative assessment of computational models for retinotopic map formation.	EPHA3 EPHA5	1.58e-04	10	66	2	25367067
Pubmed	EphrinA5 Signaling Is Required for the Distinctive Targeting of Raphe Serotonin Neurons in the Forebrain.	EPHA3 EPHA5	1.58e-04	10	66	2	28197551
Pubmed	EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes.	EPHA3 EPHA5	1.58e-04	10	66	2	16547242
Pubmed	Bidirectional ephrinB3/EphA4 signaling mediates the segregation of medial ganglionic eminence- and preoptic area-derived interneurons in the deep and superficial migratory stream.	EPHA3 EPHA5	1.93e-04	11	66	2	22171039
Pubmed	Genetics of early mammalian folliculogenesis.	FSHR ZP2	1.93e-04	11	66	2	16416028
Pubmed	Selective inhibition of spinal cord neurite outgrowth and cell survival by the Eph family ligand ephrin-A5.	EPHA3 EPHA5	1.93e-04	11	66	2	10559410
Pubmed	ApoER2 Controls Not Only Neuronal Migration in the Intermediate Zone But Also Termination of Migration in the Developing Cerebral Cortex.	ACAN TBR1	1.93e-04	11	66	2	27909010
Pubmed	Expression of ephrin-A ligands and EphA receptors in the developing mouse tooth and its supporting tissues.	EPHA3 EPHA5	1.93e-04	11	66	2	15517401
Pubmed	Mapping to molecular resolution in the T to H-2 region of the mouse genome with a nested set of meiotic recombinants.	HLA-F MAP3K4	1.93e-04	11	66	2	2911572
Pubmed	Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling.	DCC EPHA3 EPHA5	1.97e-04	59	66	3	31351040
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	BMP1 FRAS1 PPP1R13B NEB	2.05e-04	152	66	4	34299191
Pubmed	EphrinA-EphA receptor interactions in mouse spinal neurulation: implications for neural fold fusion.	EPHA3 EPHA5	2.31e-04	12	66	2	19247962
Pubmed	HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis.	HIF1A ACAN	2.31e-04	12	66	2	17913788
Pubmed	Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2.	CSGALNACT2 ACAN	2.31e-04	12	66	2	29287114
Pubmed	Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny.	KIF2A TBR1	2.31e-04	12	66	2	31919497
Pubmed	Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.	ACOT4 TMED10	2.31e-04	12	66	2	7596406
Pubmed	Meiotic mapping of murine chromosome 17: the string of loci around l(17)-2Pas.	HLA-F MAP3K4	2.73e-04	13	66	2	1794044
Pubmed	The zinc finger gene Fezf2 is required for the development of excitatory neurons in the basolateral complex of the amygdala.	TBR1 EPHA3	2.73e-04	13	66	2	24723342
Pubmed	Eph-ephrin A system regulates murine blastocyst attachment and spreading.	EPHA3 EPHA5	2.73e-04	13	66	2	17039519
Pubmed	Sub-milliMorgan map of the proximal part of mouse Chromosome 17 including the hybrid sterility 1 gene.	HLA-F MAP3K4	2.73e-04	13	66	2	8835526
Pubmed	EphA family gene expression in the developing mouse neocortex: regional patterns reveal intrinsic programs and extrinsic influence.	EPHA3 EPHA5	2.73e-04	13	66	2	12528186
Pubmed	NOVA2-mediated RNA regulation is required for axonal pathfinding during development.	DCC EPHA5	3.18e-04	14	66	2	27223325
Pubmed	Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain.	TBR1 DCC	3.18e-04	14	66	2	27648578
Pubmed	Vitamin A-enhanced cleft palate susceptibility gene maps between C4 and B144 within the H-2 complex.	ACP1 HLA-F	3.18e-04	14	66	2	8456115
Pubmed	Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue.	EPHA3 EPHA5	3.18e-04	14	66	2	26941654
Pubmed	A role for the EphA family in the topographic targeting of vomeronasal axons.	EPHA3 EPHA5	3.18e-04	14	66	2	11222144
Pubmed	Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart.	EPHA3 EPHA5	3.67e-04	15	66	2	16380715
Pubmed	Genetic dissection of plexin signaling in vivo.	ACAN TBR1	3.67e-04	15	66	2	24469813
Pubmed	Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.	KDM4C FSHR	3.67e-04	15	66	2	20923822
Pubmed	In the developing cerebral cortex: axonogenesis, synapse formation, and synaptic plasticity are regulated by SATB2 target genes.	EPHA3 EPHA5	3.67e-04	15	66	2	36028553
Pubmed	MARCKS Is Necessary for Netrin-DCC Signaling and Corpus Callosum Formation.	TBR1 DCC	3.67e-04	15	66	2	29546593
Pubmed	Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice.	TBR1 DCC	3.67e-04	15	66	2	19961580
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	PTPN13 DYNC2H1 ACP1 NEB PPP2R3C	3.71e-04	322	66	5	26514267
Pubmed	NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord.	DCC EPHA5	4.18e-04	16	66	2	27223328
Pubmed	The HSP90 family of genes in the human genome: insights into their divergence and evolution.	HSP90AB4P HSP90AB3P	4.18e-04	16	66	2	16269234
Pubmed	Genetic mapping of the t-complex region on mouse chromosome 17 including the Hybrid sterility-1 gene.	HLA-F MAP3K4	4.18e-04	16	66	2	1799792
Pubmed	High-resolution comparative mapping of mouse chromosome 17.	HLA-F MAP3K4	4.18e-04	16	66	2	8406442
Pubmed	Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping.	DCC ALPK2	4.74e-04	17	66	2	19690890
Pubmed	Disruption of segmental neural crest migration and ephrin expression in delta-1 null mice.	EPHA3 EPHA5	4.74e-04	17	66	2	12217323
Pubmed	Development of the prethalamus is crucial for thalamocortical projection formation and is regulated by Olig2.	EPHA3 EPHA5	5.32e-04	18	66	2	24803655
Pubmed	Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities.	FRAS1 DCC	5.32e-04	18	66	2	20602751
Pubmed	Expression of Ephs and ephrins in developing mouse inner ear.	EPHA3 EPHA5	5.94e-04	19	66	2	12684176
Pubmed	Genetic mapping of five mouse genes encoding synaptotagmins.	ACAN ZP2	5.94e-04	19	66	2	8747928
Pubmed	Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.	CAD NCEH1 TMED10	5.97e-04	86	66	3	25044020
Pubmed	Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.	EPHA5 HSP90AB3P	6.59e-04	20	66	2	22174851
Pubmed	Multiple roles of EPH receptors and ephrins in neural development.	EPHA3 EPHA5	6.59e-04	20	66	2	11256076
Pubmed	The ephrins and Eph receptors in neural development.	EPHA3 EPHA5	6.59e-04	20	66	2	9530499
Pubmed	Eph receptors and ephrins: effectors of morphogenesis.	EPHA3 EPHA5	6.59e-04	20	66	2	10207129
Pubmed	Development of midline cell types and commissural axon tracts requires Fgfr1 in the cerebrum.	TBR1 DCC	6.59e-04	20	66	2	16309667
Pubmed	Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation.	METTL9 STK40	6.59e-04	20	66	2	21784977
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP1 TLL2	9.03e-05	6	45	2	894
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHA3 EPHA5	5.41e-04	14	45	2	1095
GeneFamily	WD repeat domain containing\|Protein phosphatase 2 regulatory subunits	PPP2R3A PPP2R3C	6.23e-04	15	45	2	696
GeneFamily	Fibronectin type III domain containing	DCC EPHA3 EPHA5	7.35e-03	160	45	3	555
GeneFamily	Ubiquitin specific peptidases	USP44 USP6	8.57e-03	56	45	2	366
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	PAMR1 ACAN	8.86e-03	57	45	2	1179
GeneFamily	Clustered protocadherins	PCDHGA9 PCDHGA8	1.11e-02	64	45	2	20
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	PPP1R13B NEB ALPK2 WNK2 EPHA5 PLCE1	3.63e-07	188	66	6	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	POLR3GL AASS ACP1 AKAP10 TP53RK TMED10	3.74e-07	189	66	6	160963355256f7c0f2138da80c90de478f5a9fe8
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 AASS FSHR DCC EPHA5	4.01e-06	160	66	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 AASS FSHR DCC EPHA5	4.01e-06	160	66	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 DCC NEB EPHA5 PLCE1	7.91e-06	184	66	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 DCC NEB EPHA5 PLCE1	7.91e-06	184	66	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 DCC NEB EPHA5 PLCE1	7.91e-06	184	66	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	PPP2R3A PPP1R13B NCEH1 ALPK2 WNK2	8.55e-06	187	66	5	78cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|RV / Chamber and Cluster_Paper	PPP2R3A PPP1R13B NCEH1 ALPK2 WNK2	9.01e-06	189	66	5	9c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	PPP2R3A PPP1R13B NCEH1 ALPK2 WNK2	9.01e-06	189	66	5	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP1 FRAS1 PTPN13 PAMR1 ALPK2	9.48e-06	191	66	5	9214655dca96d766737c9f30b624d7fe7050342e
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	PPP2R3A PPP1R13B NCEH1 ALPK2 WNK2	9.72e-06	192	66	5	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	FRAS1 PPP2R3A PPP1R13B ALPK2 WNK2	1.02e-05	194	66	5	c3535f7cc0076653c72db582047cff053c322397
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RAMP3 METTL9 AASS NKAIN3 PLCE1	1.16e-05	199	66	5	a900ef002e1ae583b70be0253d8c44dae6754916
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TLL2 NXPE1 PPP1R13L EPHA5	4.70e-05	134	66	4	64979e1a056b7406e1be39c5ebe2f8d731ac3c17
Drug	Chloroquine diphosphate [50-63-5]; Up 200; 7.8uM; PC3; HT_HG-U133A	AASS DIPK1A DCAF17 PPP1R13B AKAP10 KIF2A BANK1	1.44e-06	196	65	7	7251_UP
Disease	mental development measurement	PCDHGA9 PCDHGA8	1.39e-03	25	65	2	EFO_0008230
Disease	migraine disorder, pulse pressure measurement	DYNC2H1 PLCE1	1.50e-03	26	65	2	EFO_0005763, MONDO_0005277
Disease	alcohol consumption measurement	CAD KDM4C PPP1R13B KIF2A MED1 DCC SVOP BANK1 EPHA3	1.54e-03	1242	65	9	EFO_0007878
Disease	functional brain measurement, language measurement	EPHA3 PLCE1	1.74e-03	28	65	2	EFO_0007797, EFO_0007849
Disease	muscular atrophy (biomarker_via_orthology)	HSP90AB4P HSP90AB3P	1.87e-03	29	65	2	DOID:767 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
DPYTFAEIDDSEYDM	BANK1	576	Q8NDB2
EDAYSMEYVYEDVDG	EP400	2226	Q96L91
YVYQMICDTGEEEET	DCAF17	501	Q5H9S7
DLEYLECSDVMTDYS	ALPK2	326	Q86TB3
CESALFYFSEYMEKE	AKAP10	386	O43572
TCKETFNMYYFESDD	EPHA5	146	P54756
ATECFGDMLYPYVEE	AASS	411	Q9UDR5
CETVISYYTDMEEIG	PIK3AP1	256	Q6ZUJ8
VEEETDCGYDYMELF	BMP1	911	P13497
EEMEEGYIQCSQFLY	PPP1R13B	996	Q96KQ4
YMYDEQGAEYIDCIS	PHYKPL	41	Q8IUZ5
EFIVYYESFTNCTEM	RAMP3	61	O60896
EEYAEEFRTYLEGEC	HLA-F	171	P30511
SLDYEECSFYEMEIQ	PCDHGA8	306	Q9Y5G5
QECLTYDGEMDYKTY	PPP2R3C	316	Q969Q6
DSFGYDDFMIYCDNI	OTUD6A	196	Q7L8S5
YAYESMDIEFECTVS	DCC	341	P43146
FVYACYVISISMEEE	NKAIN3	161	Q8N8D7
TFDAYYDMTELIDVC	FRAS1	3436	Q86XX4
FEVVYMTEPIDEYCV	HSP90AB3P	381	Q58FF7
FEVIYMSEPIDEYCV	HSP90AB4P	416	Q58FF6
PSEYCFYVDSDMVNE	HIF1A	516	Q16665
TVVMEEIEEAYCYTS	HMGXB3	11	Q12766
SLDYEECSFYEMEIQ	PCDHGA9	306	Q9Y5G4
YYDELCTAMAEELNA	NCEH1	126	Q6PIU2
FGDIMIDYTYVECTS	LSS	521	P48449
IPEMCFIYSEENIEY	KDM4C	686	Q9H3R0
LCEGDMYNDYYVLDD	METTL9	296	Q9H1A3
VLSMYELEYFYEEQC	PPP2R3A	991	Q06190
ELEYFYEEQCERMEA	PPP2R3A	996	Q06190
ELEFYNMVYAADCFD	IPMK	86	Q8NFU5
TYDVYCFAEEMEGEV	ACAN	241	P16112
LEMTEEVDYDVDSYA	KIF2A	646	O00139
CVQMVDSEFQYTYEY	DYNC2H1	1641	Q8NCM8
VLMFFCDVDIYFSAE	CSGALNACT2	361	Q8N6G5
LYYECYSDVSVHEEM	PRMT6	46	Q96LA8
CKETFNLYYMESDDD	EPHA3	116	P29320
DMADLYEYKYCTDVD	BTBD7	131	Q9P203
FDMTYTEFDYDLCNE	FSHR	326	P23945
FCGDLYVMESVEYTS	DIPK1A	221	Q5T7M9
YADCATYLADVEQSM	PPP1R13L	741	Q8WUF5
CYITSDMFYVEVQLD	MED1	101	Q15648
EYFTEATKMNGCEEY	PTPN13	2111	Q12923
CEYLDDRDQEAFYCM	NXPE1	231	Q8N323
LEFDYMCQYDYVEVR	PAMR1	171	Q6UXH9
YIFMEYCDEGTLEEV	MAP3K4	1416	Q9Y6R4
EEHEEETDYIMSYFD	POLR3GL	186	Q9BT43
CSLACEYLSEEDYMD	SVOP	361	Q8N4V2
VTEECSQYEFENYMR	STK40	366	Q8N2I9
FRDNYDTIYTGCDMD	TBR1	391	Q16650
QFYEMYNSVAEEDLC	PLCE1	121	Q9P212
EDFATFDYILCMDES	ACP1	81	P24666
FVMEDEAYKYITEAD	ARHGAP5	456	Q13017
DNISLEYFEEAVCYM	ACOT4	201	Q8N9L9
CMEELFSDVDSPYYD	CDCA4	176	Q9BXL8
YSEQVYDACMETFDC	PPP3CC	166	P48454
AFTTEDYDMFEVCFE	TMED10	96	P49755
PYEAEDFVCDYHLEM	TMEM94	541	Q12767
RTFEVEEEADCGYDY	TLL2	936	Q9Y6L7
EEEADCGYDYMEAYD	TLL2	941	Q9Y6L7
TDYDMCDRLYFDEIS	CAD	981	P27708
VFFVDYASNCLYMEE	TP53RK	101	Q96S44
EHYDESVDVYAFGMC	WNK2	371	Q9Y3S1
LCTQDGFMDVEVYSY	ZP2	371	Q05996
EVNEMYVFCYLCDDY	USP44	71	Q9H0E7
TSEEELGESEMYYCS	USP6	1041	P35125
EEYEDENTLFDMVCE	KIAA1958	136	Q8N8K9
MADDEDYEEVVEYYT	NEB	1	P20929