Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

GLUD1 GLUD2

3.83e-0521242GO:0016639
GeneOntologyMolecularFunctionglutamate dehydrogenase [NAD(P)+] activity

GLUD1 GLUD2

3.83e-0521242GO:0004353
GeneOntologyMolecularFunctionglutamate dehydrogenase (NAD+) activity

GLUD1 GLUD2

3.83e-0521242GO:0004352
GeneOntologyMolecularFunctionglutamate dehydrogenase (NADP+) activity

GLUD1 GLUD2

3.83e-0521242GO:0004354
GeneOntologyMolecularFunctionoleoyl-CoA ligase activity

SLC27A1 ACSL5

2.28e-0441242GO:0090434
GeneOntologyMolecularFunctionNAD+ binding

HPGD GLUD1 GLUD2

2.47e-04201243GO:0070403
GeneOntologyBiologicalProcessglutamate biosynthetic process

GLS GLUD1 GLUD2

2.05e-0651233GO:0006537
GeneOntologyBiologicalProcesssmall molecule biosynthetic process

SRD5A3 BAAT BHMT ADK FASN SLC35B4 GLS DHRS9 GLUD1 GLUD2 SLC25A10 GATD1 TNF PPIP5K2 PCK2

1.23e-0567612315GO:0044283
GeneOntologyCellularComponentRAVE complex

DMXL2 DMXL1

1.08e-0431262GO:0043291
DomainELFV_dehydrog_N

GLUD1 GLUD2

4.16e-0521212PF02812
DomainGlu/Leu/Phe/Val_DH_C

GLUD1 GLUD2

4.16e-0521212IPR006096
DomainGlu/Leu/Phe/Val_DH_dimer_dom

GLUD1 GLUD2

4.16e-0521212IPR006097
DomainGlu/Leu/Phe/Val_DH

GLUD1 GLUD2

4.16e-0521212IPR006095
DomainELFV_dehydrog

GLUD1 GLUD2

4.16e-0521212PF00208
DomainNAD_bind_Glu_DH

GLUD1 GLUD2

4.16e-0521212IPR033922
DomainGLFV_DEHYDROGENASE

GLUD1 GLUD2

4.16e-0521212PS00074
DomainRav1p_C

DMXL2 DMXL1

4.16e-0521212IPR022033
DomainELFV_dehydrog

GLUD1 GLUD2

4.16e-0521212SM00839
DomainGlu/Leu/Phe/Val_DH_AS

GLUD1 GLUD2

4.16e-0521212IPR033524
DomainRav1p_C

DMXL2 DMXL1

4.16e-0521212PF12234
DomainEamA

SLC35G4 SLC35G3 SLC35G5

9.16e-05141213PF00892
DomainEamA_dom

SLC35G4 SLC35G3 SLC35G5

9.16e-05141213IPR000620
DomainYjeF_N

EDC3 YJEFN3

1.24e-0431212PF03853
DomainYJEF_N

EDC3 YJEFN3

1.24e-0431212PS51385
Domain-

EDC3 YJEFN3

1.24e-04312123.40.50.10260
DomainYjeF_N_dom

EDC3 YJEFN3

1.24e-0431212IPR004443
DomainSushi

CFH TPO SVEP1 SEZ6

3.57e-04521214PF00084
DomainCCP

CFH TPO SVEP1 SEZ6

4.13e-04541214SM00032
DomainVWF_A

ITGA10 ITGAL SVEP1 PARP4 ANAPC1

4.62e-04991215IPR002035
DomainSUSHI

CFH TPO SVEP1 SEZ6

4.75e-04561214PS50923
DomainVWA

ITGA10 ITGAL SVEP1 PARP4

4.75e-04561214PF00092
DomainFG-GAP

ITGA10 BBS2 ITGAL

4.86e-04241213PF01839
DomainFG-GAP

ITGA10 BBS2 ITGAL

4.86e-04241213IPR013517
DomainSushi_SCR_CCP_dom

CFH TPO SVEP1 SEZ6

5.08e-04571214IPR000436
DomainHECT

SMURF1 HERC3 HERC2

6.93e-04271213PF00632
DomainHECTc

SMURF1 HERC3 HERC2

6.93e-04271213SM00119
DomainHECT_dom

SMURF1 HERC3 HERC2

6.93e-04271213IPR000569
DomainHECT

SMURF1 HERC3 HERC2

6.93e-04271213PS50237
DomainTransglut_N

F13A1 TGM7

1.45e-0391212PF00868
DomainTRANSGLUTAMINASES

F13A1 TGM7

1.45e-0391212PS00547
Domain-

F13A1 TGM7

1.45e-03912123.90.260.10
DomainGln_gamma-glutamylTfrase_euk

F13A1 TGM7

1.45e-0391212IPR023608
DomainTransglutaminase_AS

F13A1 TGM7

1.45e-0391212IPR013808
DomainTransglutaminase_N

F13A1 TGM7

1.45e-0391212IPR001102
DomainTransglut_C

F13A1 TGM7

1.45e-0391212PF00927
DomainTransglutaminase_C

F13A1 TGM7

1.81e-03101212IPR008958
Domain-

ACAT2 FASN

1.81e-031012123.40.47.10
DomainThiolase-like

ACAT2 FASN

1.81e-03101212IPR016039
DomainVWFA

ITGA10 ITGAL SVEP1 PARP4

1.99e-03821214PS50234
DomainVWA

ITGA10 ITGAL SVEP1 PARP4

2.17e-03841214SM00327
DomainTransglutaminase-like

F13A1 TGM7

2.20e-03111212IPR002931
DomainTGc

F13A1 TGM7

2.20e-03111212SM00460
DomainTransglut_core

F13A1 TGM7

2.20e-03111212PF01841
Domain-

FASN HPGD DHRS9 GLUD1 GLUD2

4.89e-0316912153.40.50.720
DomainNAD(P)-bd_dom

FASN HPGD DHRS9 GLUD1 GLUD2

5.39e-031731215IPR016040
Domainadh_short

FASN HPGD DHRS9

5.45e-03551213PF00106
DomainIntegrin_alpha-2

ITGA10 ITGAL

5.95e-03181212IPR013649
DomainINTEGRIN_ALPHA

ITGA10 ITGAL

5.95e-03181212PS00242
DomainIntegrin_alpha2

ITGA10 ITGAL

5.95e-03181212PF08441
DomainIntegrin_alpha

ITGA10 ITGAL

5.95e-03181212IPR000413
Domain-

DMXL2 WDR81 BBS2 EML3 DMXL1 PLXNA4 DYNC1I1

6.01e-0333312172.130.10.10
DomainWD40/YVTN_repeat-like_dom

DMXL2 WDR81 BBS2 EML3 DMXL1 PLXNA4 DYNC1I1

6.20e-033351217IPR015943
PathwayKEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION

GLS GLUD1 GLUD2 SLC25A10 PCK2

3.08e-0723915M4361
PathwayWP_AMINO_ACID_METABOLISM

TPO MCCC1 BHMT GLS GLUD1 GLUD2

4.00e-0598916MM15942
PathwayREACTOME_GLUTAMATE_AND_GLUTAMINE_METABOLISM

GLS GLUD1 GLUD2

9.00e-0514913MM15570
PathwayREACTOME_GLUTAMATE_AND_GLUTAMINE_METABOLISM

GLS GLUD1 GLUD2

9.00e-0514913M27851
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

IMPDH2 OBSL1 PEX1 FTSJ1 STK11IP TUBA4A PARP4 TRMT2A BRCA2 TELO2 ANAPC1 GLUD1 GLUD2 GATD1 HERC2

6.06e-096061261536538041
Pubmed

RT-PCR of fatty acid elongases.

SLC35G4 SLC35G3 SLC35G5

1.85e-07412639056918
Pubmed

Emergence of primate genes by retrotransposon-mediated sequence transduction.

SLC35G4 SLC35G3 SLC35G5

1.85e-074126317101974
Pubmed

Macrophage-derived glutamine boosts satellite cells and muscle regeneration.

GLS GLUD1 GLUD2

4.62e-075126333116312
Pubmed

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.

GLUD1 GLUD2 TNF

1.61e-067126319498109
Pubmed

Proteomic analysis of the mouse liver mitochondrial inner membrane.

MCCC1 YJEFN3 GLUD1 GLUD2 SLC25A10 HERC2 ACSL5

3.70e-06175126712865426
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

GLIPR1 CFH ZSWIM8 DMXL2 JADE2 ENC1 OBSL1 PREPL TRIM33 FBN1 PPP5C DAZAP1 SACS GLS GLUD1 HERC2 DYNC1I1

4.15e-0612851261735914814
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

PPAN CLTCL1 MB TEX35 INSYN2A FASN SACS SLC27A1 GLS GLUD1 GLUD2 PLXNA4 MTTP NAV2 PPIP5K2 KIAA2012 DYNC1I1 KIF11

4.72e-0614421261835575683
Pubmed

Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.

TUBA4A DMXL1 SACS HERC2 KIF11

8.66e-0676126527542412
Pubmed

Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.

GLUD1 GLUD2

1.30e-052126228621566
Pubmed

GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior.

GLUD1 GLUD2

1.30e-052126232078638
Pubmed

Recent advances in tumor necrosis factor and CD40 signaling.

CD40 TNF

1.30e-05212628791485
Pubmed

Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.

GLUD1 GLUD2

1.30e-052126228911206
Pubmed

Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.

GLUD1 GLUD2

1.30e-052126215578726
Pubmed

Induction of excitatory and inhibitory presynaptic differentiation by GluD1.

GLUD1 GLUD2

1.30e-052126222138648
Pubmed

Potentiation of neuronal activity by tonic GluD1 current in brain slices.

GLUD1 GLUD2

1.30e-052126237154294
Pubmed

CD40-independent natural killer-cell help promotes dendritic cell vaccine-induced T-cell immunity against endogenous B-cell lymphoma.

CD40 TNF

1.30e-052126224771135
Pubmed

Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory.

GLUD1 GLUD2

1.30e-052126231898404
Pubmed

Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.

GLUD1 GLUD2

1.30e-052126215378063
Pubmed

Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.

GLUD1 GLUD2

1.30e-052126220529287
Pubmed

Bub1 suppresses inflammatory arthritis-associated bone loss in mice through inhibition of TNFα-mediated osteoclastogenesis.

BUB1 TNF

1.30e-052126238477771
Pubmed

Unexpected histone H3 tail-clipping activity of glutamate dehydrogenase.

GLUD1 GLUD2

1.30e-052126223673664
Pubmed

Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.

GLUD1 GLUD2

1.30e-052126224442550
Pubmed

The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity.

GLUD1 GLUD2

1.30e-052126227137930
Pubmed

GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.

GLUD1 GLUD2

1.30e-052126226440896
Pubmed

Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme.

GLUD1 GLUD2

1.30e-052126212742085
Pubmed

Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection.

GLUD1 GLUD2

1.30e-052126218688271
Pubmed

Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.

GLUD1 GLUD2

1.30e-052126219015267
Pubmed

Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors.

GLUD1 GLUD2

1.30e-052126234173171
Pubmed

Tumor necrosis factor alpha enhances Actinobacillus actinomycetemcomitans leukotoxin-induced HL-60 cell apoptosis by stimulating lymphocyte function-associated antigen 1 expression.

ITGAL TNF

1.30e-052126214688105
Pubmed

Development of mice with brain-specific deletion of floxed glud1 (glutamate dehydrogenase 1) using cre recombinase driven by the nestin promoter.

GLUD1 GLUD2

1.30e-052126223595828
Pubmed

Interaction between glutamate dehydrogenase (GDH) and L-leucine catabolic enzymes: intersecting metabolic pathways.

GLUD1 GLUD2

1.30e-052126221621574
Pubmed

Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.

GLUD1 GLUD2

1.30e-052126222875990
Pubmed

Important role of Ser443 in different thermal stability of human glutamate dehydrogenase isozymes.

GLUD1 GLUD2

1.30e-052126215044002
Pubmed

Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia.

GLUD1 GLUD2

1.30e-052126234220417
Pubmed

Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues.

GLUD1 GLUD2

1.30e-052126226241911
Pubmed

Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum.

GLUD1 GLUD2

1.30e-052126221446915
Pubmed

Depletion of OLFM4 gene inhibits cell growth and increases sensitization to hydrogen peroxide and tumor necrosis factor-alpha induced-apoptosis in gastric cancer cells.

OLFM4 TNF

1.30e-052126222471589
Pubmed

GluD1 binds GABA and controls inhibitory plasticity.

GLUD1 GLUD2

1.30e-052126238060673
Pubmed

Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice.

GLUD1 GLUD2

1.30e-052126224593767
Pubmed

Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.

GLUD1 GLUD2

1.30e-052126222924626
Pubmed

Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.

GLUD1 GLUD2

1.30e-052126211032875
Pubmed

Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes.

GLUD1 GLUD2

1.30e-052126229943084
Pubmed

Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.

GLUD1 GLUD2

1.30e-052126227422263
Pubmed

Synergic effect of polymorphisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition.

CFH ERCC6

1.30e-052126216754848
Pubmed

Critical role of the cysteine 323 residue in the catalytic activity of human glutamate dehydrogenase isozymes.

GLUD1 GLUD2

1.30e-052126215750346
Pubmed

Critical role of CD40-mediated autocrine tumor necrosis factor-alpha in potentiation of cisplatin-induced cytotoxicity in cancer cells.

CD40 TNF

1.30e-052126222010829
Pubmed

Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA.

GLUD1 GLUD2

1.30e-05212621711373
Pubmed

Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry).

GLUD1 GLUD2

1.30e-052126225124006
Pubmed

Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.

GLUD1 GLUD2

1.30e-052126239052831
Pubmed

The cyclic AMP pathway is a sex-specific modifier of glioma risk in type I neurofibromatosis patients.

BHMT NF1

1.30e-052126225381154
Pubmed

The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology.

GLUD1 GLUD2

1.30e-052126222658952
Pubmed

Increases in anterograde axoplasmic transport in neurons of the hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic mouse: Effects of glutamate receptors on transport.

GLUD1 GLUD2

1.30e-052126238124277
Pubmed

Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum.

GLUD1 GLUD2

1.30e-052126219448744
Pubmed

Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme.

GLUD1 GLUD2

1.30e-052126211950837
Pubmed

Integrative predictive model of coronary artery calcification in atherosclerosis.

CFH TPO ERCC6 F13A1 BHMT CD40 TNF

2.13e-05229126719948975
Pubmed

LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.

GLS GLUD1 GLUD2 PCK2

2.38e-0546126435237793
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

DMXL2 IMPDH2 OBSL1 PEX1 ANKRD50 TUBA4A PARP4 TRMT2A BUB1 SLC25A10 PPIP5K2

2.60e-056501261138777146
Pubmed

Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.

CLTCL1 TUBA4A GLS GLUD1 GLUD2

2.84e-0597126522360420
Pubmed

Wilms Tumor Predisposition

DIS3L2 NF1 BRCA2

3.64e-0518126320301471
Pubmed

TNF-α promotes IFN-γ-induced CD40 expression and antigen process in Myb-transformed hematological cells.

CD40 TNF

3.90e-053126222547990
Pubmed

Characterization of the tetratricopeptide-containing domain of BUB1, BUBR1, and PP5 proves that domain amphiphilicity over amino acid sequence specificity governs protein adsorption and interfacial activity.

PPP5C BUB1

3.90e-053126218547097
Pubmed

Autocrine TNF-α-mediated NF-κB activation is a determinant for evasion of CD40-induced cytotoxicity in cancer cells.

CD40 TNF

3.90e-053126223751348
Pubmed

Antitumor effects of a drug combination targeting glycolysis, glutaminolysis and de novo synthesis of fatty acids.

FASN GLS

3.90e-053126226134042
Pubmed

SIRT5 regulation of ammonia-induced autophagy and mitophagy.

GLS GLUD1

3.90e-053126225700560
Pubmed

CD40/CD40 ligand interactions and TNFα treatment reduce activity of P105 promoter of the human papilloma virus-18 in vitro.

CD40 TNF

3.90e-053126227031714
Pubmed

Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.

GLUD1 GLUD2

3.90e-053126229784783
Pubmed

The expression of glutamine-metabolism-related proteins in breast phyllodes tumors.

GLS GLUD1

3.90e-053126223636801
Pubmed

Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis.

GLUD1 GLUD2

3.90e-053126230002133
Pubmed

Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens.

GLUD1 GLUD2

3.90e-053126230315226
Pubmed

Isolation of a human brain cDNA for glutamate dehydrogenase.

GLUD1 GLUD2

3.90e-05312623585334
Pubmed

ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis.

EDC3 YJEFN3

3.90e-053126217533573
Pubmed

GOT1 regulates CD8+ effector and memory T cell generation.

GLUD1 GLUD2

3.90e-053126236640309
Pubmed

Screening for new inhibitors of the human Mitochondrial Pyruvate Carrier and their effects on hepatic glucose production and diabetes.

GLUD1 GLUD2

3.90e-053126237871770
Pubmed

Smurf1 represses TNF-α production through ubiquitination and destabilization of USP5.

SMURF1 TNF

3.90e-053126227133717
Pubmed

Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40.

CD40 TNF

3.90e-053126212881420
Pubmed

Identification of disulfide bond formation between MitoNEET and glutamate dehydrogenase 1.

GLUD1 GLUD2

3.90e-053126224295216
Pubmed

The structure of apo human glutamate dehydrogenase details subunit communication and allostery.

GLUD1 GLUD2

3.90e-053126212054821
Pubmed

Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons.

GLUD1 GLUD2

3.90e-053126231704028
Pubmed

Tumor Necrosis Factor alpha (TNFalpha) regulates CD40 expression through SMAR1 phosphorylation.

CD40 TNF

3.90e-053126220006573
Pubmed

MiR-338-3p inhibits TNF-α-induced lipogenesis in human sebocytes.

PREX2 TNF

3.90e-053126228597147
Pubmed

Expression of enzymes regulating placental ammonia homeostasis in human fetal growth restricted pregnancies.

GLS GLUD1

3.90e-053126219500843
Pubmed

Impaired phosphorylation and mis-localization of Bub1 and BubR1 are responsible for the defective mitotic checkpoint function in Brca2-mutant thymic lymphomas.

BRCA2 BUB1

3.90e-053126214646599
Pubmed

Tumour suppressor TRIM33 targets nuclear β-catenin degradation.

TRIM33 PRKCG

3.90e-053126225639486
Pubmed

Neurofibromatosis with male breast cancer--risk factor or co-incidence? Report of two rare cases.

NF1 BRCA2

3.90e-053126225267367
Pubmed

Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis.

FBN1 BRCA2

3.90e-053126225749384
Pubmed

Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer.

GLS GLUD1

3.90e-053126223507704
Pubmed

Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase.

GLUD1 GLUD2

3.90e-053126229229616
Pubmed

Critical role of tumor necrosis factor-alpha and NF-kappa B in interferon-gamma -induced CD40 expression in microglia/macrophages.

CD40 TNF

3.90e-053126211830590
Pubmed

Complement factor H attenuates TNF-α-induced inflammation by upregulating EIF3C in rheumatoid arthritis.

CFH TNF

3.90e-053126237996918
Pubmed

Inhibition of lung cancer cell proliferation by CD40 signaling through tumor necrosis factor I.

CD40 TNF

3.90e-053126219448410
Pubmed

Deletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficit in fear conditioning.

GLUD1 GLUD2

3.90e-053126223560106
Pubmed

Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase.

GLUD1 GLUD2

3.90e-053126220670938
Pubmed

The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers.

FASN GLS

3.90e-053126232698888
Pubmed

Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha in transgenic mice expressing keratin K10 in the basal layer of the epidermis.

SLC27A1 TNF

3.90e-053126212566451
Pubmed

The chromosomal location of the mouse mammary tumor gene Int6 and related pseudogenes in the mouse genome.

GLUD1 GLUD2 TNF

4.31e-051912637558022
Pubmed

PEX14 is required for microtubule-based peroxisome motility in human cells.

IMPDH2 PEX1 TUBA4A KIF11

4.51e-0554126421525035
Pubmed

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.

GLUD1 GLUD2

7.78e-054126223663782
Pubmed

Association of four DNA polymorphisms with acute rejection after kidney transplantation.

IMPDH2 TNF

7.78e-054126218444945
Pubmed

A restriction fragment length polymorphism at murine Glud locus co-segregates with Rib-1, Es-10, and Tcra on chromosome 14.

GLUD1 GLUD2

7.78e-05412622566156
InteractionMLST8 interactions

DEPTOR ACAT2 TUBA4A FASN TRMT2A CD40 KIF11

4.48e-061091227int:MLST8
InteractionCLEC16A interactions

IMPDH2 OBSL1 PEX1 FTSJ1 STK11IP TUBA4A PARP4 TRMT2A BRCA2 TELO2 ANAPC1 GLUD1 GLUD2 GATD1 HERC2

6.19e-0662912215int:CLEC16A
InteractionDNAJC7 interactions

DMXL2 LAMA1 SMURF1 OBSL1 DMXL1 FASN NF1 BRCA2 SACS TELO2 HERC2 DYNC1I1

1.06e-0542512212int:DNAJC7
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

CFH TPO SVEP1 SEZ6

1.06e-04577841179
GeneFamilyTransglutaminases

F13A1 TGM7

6.49e-049782773
GeneFamilyCD molecules|Integrin alpha subunits

ITGA10 ITGAL

2.69e-03187821160
GeneFamilyRing finger proteins|Fanconi anemia complementation groups|Protein phosphatase 1 regulatory subunits|BRCA1 A complex|BRCA1 B complex|BRCA1 C complex

FANCL BRCA2

3.32e-0320782548
GeneFamilyAnkyrin repeat domain containing

ASB14 ANKRD50 DZANK1 GLS INVS

3.94e-03242785403
GeneFamilyShort chain dehydrogenase/reductase superfamily

FASN HPGD DHRS9

4.33e-0376783743
GeneFamilyWD repeat domain containing

DMXL2 WDR81 EML3 DMXL1 DYNC1I1

5.50e-03262785362
GeneFamilyAcyl-CoA synthetase family

SLC27A1 ACSL5

5.58e-032678240
GeneFamilyPHD finger proteins

JADE2 FANCL TRIM33

6.93e-039078388
GeneFamilySolute carriers

SLC35G4 SLC35G3 SLC35B4 SLC27A1 SLC25A10 SLC35G5

7.17e-03395786752
CoexpressionAtlasB cells, proB.CLP.BM, CD19- IgM- CD43+ CD24- AA4.1+ CD45R- CD117+ IL7R+, Bone marrow, avg-1

DMXL2 IMPDH2 OLFM4 HLX SH2D5 F13A1 BRCA2 SLC27A1 DHRS9 BUB1 KIF11

2.07e-0540512111GSM538343_500
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGAL F13A1 SLC35G4 BRCA2 GZMK BUB1 TGM7 KIF11

6.33e-08187126873931a5ea73799095daff100b5f18853c57c74dc
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CFH TSPAN11 PREX2 F13A1 SVEP1 FBN1 NAV2 CACNA1G

1.06e-07200126858b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CFH ITGA10 SVEP1 KLHL29 FBN1 NAV2 DYNC1I1

1.67e-062001267a4ec0e80f5422b91b85264a9bb74568dd577e285
ToppCell15-Airway-Epithelial-Submucosal_gland_basal|Airway / Age, Tissue, Lineage and Cell class

LAMA1 IRX4 GRID2IP UNC5CL CD40 ELAPOR1

9.02e-06170126661f8dd5e27df1b8d01ccfd0d25247b34aa8d182c
ToppCellhealthy_donor-Myeloid-Monocytic-Developing_Neutrophil|healthy_donor / Disease condition, Lineage, Cell class and subclass

OLFM4 ASB14 TUBA4A BUB1 UBE2S KIF11

9.02e-061701266cfd7f29805b7c51666b0eaf269c36c96b8765a1a
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ENC1 HLX ASB14 BUB1 NAV2 KIF11

9.32e-061711266c2dbc439af28d4fabb24d57685b75b2e588819b0
ToppCelldroplet-Marrow-BM-1m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZSWIM8 ENC1 ASB14 ITGAL HPGD TNF

1.06e-051751266c1c722db42da9b8a2a46e516ddb83d9be5e2e504
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ENC1 ITGAL GZMK UBE2S TNF NXPH4

1.13e-05177126684930899eb2978598bc8a351cbcd9e714e46799d
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DMXL2 ITGAL TUBA4A BUB1 HERC3 KIF11

1.33e-05182126657f8b8d7b132f3ad6f2b1e79c3812fe938657d2c
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-cycling_ENCC/glia|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BRCA2 GLUD2 BUB1 SLC25A10 UBE2S KIF11

1.37e-05183126629b62dd542bc3f8df843998f577724f3818d4271
ToppCelldroplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN11 PREX2 INSYN2A FBN1 PLXNA4 PRKCG

1.55e-051871266e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ENC1 DMXL1 ADK DZANK1 SACS SLC35G5

1.70e-051901266ed100e271aac82806f59e0c613ccda63f59100c1
ToppCellAdult-Epithelial-club_cell|Adult / Lineage, Cell type, age group and donor

CFH CDH26 TSPAN11 ENC1 ELAPOR1 PLXNA4

1.70e-051901266756bff697d30aec56c0ebfca94295f084a15bf37
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZSWIM8 PEX1 DMXL1 BRCA2 HERC3 KIF11

1.70e-0519012663f0c7d130f66faea778fe567604edf1b4cdf85b3
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZSWIM8 PEX1 DMXL1 BRCA2 HERC3 KIF11

1.80e-051921266c09dcc73ff9c3855a0f3d7bfa0d5c99c09a117f2
ToppCellLA|World / Chamber and Cluster_Paper

F13A1 SVEP1 KLHL29 FASN FBN1 NAV2

1.85e-051931266d4bf89437216baf489ea0239136dcedf3b6714af
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH PREX2 SVEP1 FBN1 NAV2 DYNC1I1

1.91e-051941266c49f72441b3557e2c3a9c4239e68c0cf0652814b
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

TUBA4A SH2D5 GLS ELAPOR1 HERC2 DYNC1I1

1.91e-0519412668aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH PREX2 SVEP1 FBN1 NAV2 DYNC1I1

1.96e-0519512663c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCellHippocampus-Macroglia-CSF_related-EPENDYMAL-Ependymal.Ccdc153_(Ccdc153)|Hippocampus / BrainAtlas - Mouse McCarroll V32

CDH26 MB ASB14 SLC35G3 UNC5CL

2.07e-05117126591936a3ffbfa29024ced9d01df962b4ccfaf8966
ToppCellHippocampus-Macroglia-CSF_related-EPENDYMAL-Ependymal.Ccdc153_(Ccdc153)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

CDH26 MB ASB14 SLC35G3 UNC5CL

2.07e-051171265e33ec9044541d2ef53f6633891238559b01b7957
ToppCellHippocampus-Macroglia-CSF_related-EPENDYMAL-Ependymal.Ccdc153_(Ccdc153)--|Hippocampus / BrainAtlas - Mouse McCarroll V32

CDH26 MB ASB14 SLC35G3 UNC5CL

2.07e-051171265454efceabe739cdf293f81c8a938811f12321a47
ToppCellHippocampus-Macroglia-CSF_related-EPENDYMAL|Hippocampus / BrainAtlas - Mouse McCarroll V32

CDH26 MB ASB14 SLC35G3 UNC5CL

2.07e-051171265409b3ab16786bced8c9bc9c0e89b0078402f365a
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

INSYN2A BRCA2 SACS BUB1 UBE2S KIF11

2.14e-0519812667225a6194c52b01c581e58d3cda107c4af96dc4f
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CFH TSPAN11 ITGA10 SVEP1 FBN1 DYNC1I1

2.20e-051991266abd6117f8a3d7e798d8471c16d97b34aaf50fc9c
ToppCellSepsis-ICU-NoSEP-Lymphocyte-T/NK-T/NK_proliferative|ICU-NoSEP / Disease, condition lineage and cell class

ACAT2 BRCA2 GZMK BUB1 UBE2S KIF11

2.26e-052001266f70cc9198339eab7fbc68f5d9b75dfb28c9afc89
ToppCellICU-NoSEP-Lymphocyte-T_NK-T_NK_proliferative|ICU-NoSEP / Disease, Lineage and Cell Type

ACAT2 BRCA2 GZMK BUB1 UBE2S KIF11

2.26e-052001266d86119766b9c4f1570cd8045313345f9be46d431
ToppCellThalamus-Macroglia-CSF_related-EPENDYMAL-Ependymal.Ccdc153_(Ccdc153)-|Thalamus / BrainAtlas - Mouse McCarroll V32

CDH26 MB ASB14 SLC35G3 UNC5CL

2.54e-051221265aca079f2f033cc1ac13c4ee02d490b6a514cbd5c
ToppCellThalamus-Macroglia-CSF_related-EPENDYMAL-Ependymal.Ccdc153_(Ccdc153)--|Thalamus / BrainAtlas - Mouse McCarroll V32

CDH26 MB ASB14 SLC35G3 UNC5CL

2.54e-051221265ac38130010f76648757eac700a8039f3960ddde3
ToppCellThalamus-Macroglia-CSF_related-EPENDYMAL|Thalamus / BrainAtlas - Mouse McCarroll V32

CDH26 MB ASB14 SLC35G3 UNC5CL

2.54e-0512212657ab0b63244116e74c5783c3293cf08224d094d0a
ToppCellThalamus-Macroglia-CSF_related|Thalamus / BrainAtlas - Mouse McCarroll V32

CDH26 MB ASB14 SLC35G3 UNC5CL

2.54e-051221265eb944243424460bf5c66aced3ed7b7a1b6486ac7
ToppCellThalamus-Macroglia-CSF_related-EPENDYMAL-Ependymal.Ccdc153_(Ccdc153)|Thalamus / BrainAtlas - Mouse McCarroll V32

CDH26 MB ASB14 SLC35G3 UNC5CL

2.54e-0512212659b0d6b0a394560ff5aadcd3b21519c2393e6def8
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Ndst4_(Superficial_layer_pyramidal_cells--dorsal_endopiriform_nucleus_or_piriform_cortex)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PINLYP OLFM4 TEX35 DHRS9

3.07e-056312641f609765ed8b3a09095427da5dab7ba03a763192
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFH TUBA4A F13A1 INSYN2A KIF11

5.98e-05146126545d7cb73776e60d22f335a651845e21e16948fcc
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZSWIM8 BAAT SBF2 MTTP TNF

6.38e-051481265e7bbb5ddf44b11b8495e83863fbf1fd9f3f24472
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Fos_(Microglia)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

HLX F13A1 HPGD UBE2S TNF

6.59e-051491265406a5ccfedbf43543f0346ff7ef3ce1d15c38f29
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

HLX F13A1 HPGD UBE2S TNF

6.59e-05149126534a3075af794052763fc7c4135f3031f89da5caa
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

HLX F13A1 HPGD UBE2S TNF

6.59e-051491265be698ecce34ddbdf57d08082b71268934675e74e
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Fos_(Microglia)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

HLX F13A1 HPGD UBE2S TNF

6.59e-051491265183c77cc8f23b8406e7241a066cb684470002a3b
ToppCellHippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)|Hippocampus / BrainAtlas - Mouse McCarroll V32

GLIPR1 PINLYP BAAT ITGAL

6.77e-05771264a799ccdb84014e978d9fbccf3d2fee8fbeac7b0c
ToppCell368C-Fibroblasts-Fibroblast-E|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ERCC6 F13A1 DZANK1 BUB1 KIF11

6.80e-051501265c3ad5fa41eb636a5d691c0268c0f1c32cd0de658
ToppCell368C-Fibroblasts-Fibroblast-E-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ERCC6 F13A1 DZANK1 BUB1 KIF11

6.80e-05150126578b8029e71d26f336a46274c8afef3435bf536b9
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell|368C / Donor, Lineage, Cell class and subclass (all cells)

BAAT SBF2 GZMK MTTP TNF

7.02e-051511265512f7f37ddc8dfa1906f7fff92b571929236c9ea
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Myeloid-macrophage|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WDR81 FANCL F13A1 CD40 NXPH4

7.47e-0515312654b999892fb797e9f0d391630094f466463299d57
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Myeloid-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WDR81 FANCL F13A1 CD40 NXPH4

7.47e-051531265e426db29e4ba83e7930dc88c74fc975b177c9540
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Myeloid|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WDR81 FANCL F13A1 CD40 NXPH4

7.47e-051531265668eacd76aad6054bd7d57e3af0b122c2443465f
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Lymphocytic|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GLIPR1 ITGAL UNC5CL GZMK TNF

8.19e-05156126539aa3adbee9f04cdc0055487d393edfa515e062b
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Lymphocytic-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GLIPR1 ITGAL UNC5CL GZMK TNF

8.19e-051561265a09e3aefe78d63ad5428ad48c6f83e547eb819f6
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

DIS3L2 ZNF577 DMXL1 FASN GLUD1

8.19e-051561265abea3c183d32062b009a79a2bdf861021989c7ef
ToppCell3'-GW_trimst-1-LargeIntestine-Epithelial-neuro-epithelial|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CDH26 MB TUBA4A ELAPOR1 PRKCG

9.22e-0516012656c89a2e4189e4f2b6b09b66c6aae6653785ab2f8
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GLIPR1 ITGAL LYPD3 TNF KIF11

9.22e-05160126594e4f5fc2156dd8163811c3b8b0781ea9b3f2e06
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CDH26 MB FAM3D DHRS9 ELAPOR1

1.01e-04163126522fa5d017ff796394394d952ec151e2d1beb8248
ToppCellICU-SEP-Lymphocyte-T_NK-MAIT|ICU-SEP / Disease, Lineage and Cell Type

CFH FANCL DZANK1 HPGD GZMK

1.04e-041641265db863a44fc0dad5518c47fdbf64ea21d6f36f089
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-CD8_low_T|T/NK_cells / Location, Cell class and cell subclass

CFH TUBA4A STRADA GZMK TNF

1.04e-04164126592fb94492fc2b683e9d50a9db6f01d23c194b0e4
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-Klrb1a/b/c(-)_NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMXL2 ITGA10 ITGAL DHRS9 TGM7

1.07e-041651265651d40eadb1b34de618af94c167f43635729d43f
ToppCellClub_cells-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

CFH TSPAN11 MB FAM3D ELAPOR1

1.10e-041661265a440aa338aa0c6cd0b5800dfa7e83f8ca16fce1a
ToppCellILEUM-non-inflamed-(1)_Cytotoxic_T_cells|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

ENC1 ITGAL TUBA4A GZMK TNF

1.10e-04166126567f9d88329724cdda11bf76e964f66456ff6fb46
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH DEPTOR SMURF1 ITGAL HPGD

1.16e-041681265e979a4fbeb9f21048b47d69e6da75c57650697f2
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

YJEFN3 SVEP1 LYPD3 NXPH4 SEZ6

1.26e-041711265a5634b76476b8b2488a706bbab5141f7bd94631f
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GLIPR1 ITGAL F13A1 BUB1 KIF11

1.26e-0417112656e7ade1d14a3ec4c566476aac3eb509bd2661e39
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HLX SVEP1 FASN FBN1 NAV2

1.26e-041711265972fab891135bd755d5526cbc5a963200067b0a6
ToppCellfacs-Trachea-18m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l12|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GLIPR1 F13A1 HPGD CD40 TNF

1.26e-04171126526755e43d94e934106fc19ab929e4d34c17d6cba
ToppCellPericytes-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

BHMT APCDD1L PLXNA4 NXPH4 DYNC1I1

1.26e-041711265bbc8d9fc83d37c9250345b1e76776610799de9ae
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HLX SVEP1 FASN FBN1 NAV2

1.26e-0417112652a77ed79c6f2e700e789c80451a70ecb31639719
ToppCell10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-CMP|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

TPO CDH26 DEPTOR IMPDH2 PREX2

1.30e-041721265f18d9f061df3da96e389616abd5edfc269d3adeb
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D122|Adult / Lineage, Cell type, age group and donor

TSPAN11 SH2D5 BHMT FBN1 DYNC1I1

1.33e-041731265dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STK11IP NF1 BUB1 NAV2 KIF11

1.37e-04174126572df66319f6efbd88ecf439013d97409fbf3cb52
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STK11IP NF1 BUB1 NAV2 KIF11

1.37e-041741265c6087fd0e036ec7f40f0f8f17d1f6ce13ddb5235
ToppCellCOVID-19-kidney-PCT-S3-2|kidney / Disease (COVID-19 only), tissue and cell type

CFH BAAT BHMT FASN MTTP

1.37e-0417412655aa2fb631505600f37d2b87b02def7be139dc262
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFH ITGA10 FBN1 MTTP NAV2

1.40e-0417512651799a7be623dc3bf53ba580a7c47d2619969d708
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_memory-B_memory-6|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZYG11A TEX35 DHRS9 CD40 NXPH4

1.40e-0417512651b3510e9078eec7cfc5805043e435e9e5e0f0877
ToppCellwk_15-18-Epithelial-PNS-Schwann_precursor|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PPAN ENC1 KLHL29 NF1 SACS

1.48e-0417712655357359e6c2161a37f39a6b3b78449f5cbc327d1
ToppCell356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CFH FAM3D INSYN2A FBN1 ELAPOR1

1.48e-041771265709235694cc711b9b79690e23c94577b2ae06811
ToppCell356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CFH FAM3D INSYN2A FBN1 ELAPOR1

1.48e-0417712657f9c2a45a994b32f15e5693f7cb873716a4eb568
ToppCelldroplet-Marrow-nan-21m-Myeloid-monocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GLIPR1 CFH F13A1 HPGD GLUD1

1.48e-041771265b860013f1fd397400a62d66ab521cfc81349ffe2
ToppCellAdult-Epithelial-club_cell-D122|Adult / Lineage, Cell type, age group and donor

CFH CDH26 TSPAN11 ENC1 ELAPOR1

1.52e-04178126535a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INSYN2A ELAPOR1 PLXNA4 NXPH4 DYNC1I1

1.56e-041791265479116ac65488c60104a053530830763ec1f95b2
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INSYN2A ELAPOR1 PLXNA4 NXPH4 DYNC1I1

1.56e-0417912651dfc0cb8b369aef35c59f3d4c52603dc9f3728c1
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INSYN2A ELAPOR1 PLXNA4 NXPH4 DYNC1I1

1.56e-04179126569a1b3b05c921de6343ffe6ad998aa2b804312a7
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CFH CDH26 ELAPOR1 PLXNA4 NAV2

1.60e-041801265b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFH TSPAN11 SVEP1 FBN1 CACNA1G

1.64e-0418112653462aa1c08fbaf613b6278ab2c7a5a0940bf537d
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFH TSPAN11 SVEP1 FBN1 CACNA1G

1.64e-0418112656730e249cac55ae892cc567d9211615882f3dab4
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CDH26 TSPAN11 PREX2 FBN1 PLXNA4

1.73e-041831265351d575339038bd4a66f408da518c567444208e8
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CFH SVEP1 FBN1 NAV2 DYNC1I1

1.77e-041841265e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BRCA2 BUB1 ELAPOR1 UBE2S KIF11

1.82e-04185126530e041d6f6e310d64809e9d6d93cd30052972f3b
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

INPP4A PARP4 SLC35B4 ELAPOR1 TNF

1.86e-04186126577bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCell368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

INPP4A PARP4 SLC35B4 ELAPOR1 TNF

1.86e-04186126513bc41c60fd628af31899a5e8b480e06cc4781be
ToppCellAdult-Epithelial-club_cell-D231|Adult / Lineage, Cell type, age group and donor

CFH CDH26 TSPAN11 ELAPOR1 PLXNA4

1.91e-041871265ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SVEP1 FBN1 BRCA2 BUB1 KIF11

1.91e-041871265e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SVEP1 FBN1 BRCA2 BUB1 KIF11

1.91e-041871265cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCelltumor_Lung-T/NK_cells-Cytotoxic_CD8+_T|tumor_Lung / Location, Cell class and cell subclass

ENC1 ITGAL TUBA4A GZMK TNF

1.91e-041871265530839fb53bb285b22919fde6aa16ce1399615ef
ToppCell15-Trachea-Epithelial-Secretory_progenitor|Trachea / Age, Tissue, Lineage and Cell class

CFH ANKRD50 HPGD ELAPOR1 NXPH4

1.91e-041871265be9fce9e74b2f170a2067f1b31d802912a578329
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-SMG_serous_secreting_cell-SMG_serous_(nasal)-SMG_serous_(nasal)_L.0.6.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DEPTOR MB FAM3D ELAPOR1 DYNC1I1

1.96e-04188126502b3aae071ff1f469d52a4d513a4eb46ae70bba3
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Proliferating_Classical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TUBA4A F13A1 BUB1 UBE2S KIF11

1.96e-041881265a6ad6de6aeaf213952124252c1452b73942a0c3d
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CFH ITGA10 PREX2 INSYN2A CACNA1G

1.96e-041881265997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-SMG_serous_secreting_cell-SMG_serous_(nasal)-SMG_serous_(nasal)_L.0.6.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DEPTOR MB FAM3D ELAPOR1 DYNC1I1

2.01e-04189126529423dc66a8af71293b2e1670acc6c34dfe63608
ToppCellCOVID-19_Severe-HSPC|COVID-19_Severe / disease group, cell group and cell class

CFH DEPTOR IMPDH2 OBSL1 PREX2

2.01e-04189126596015439971e2e5b8d6294ca5a6b873c7774e925
ToppCell5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CDH26 IMPDH2 MB FAM3D ELAPOR1

2.01e-041891265453b2acfa89e7279540109244cf986df34635df8
ToppCelldroplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFH TSPAN11 SVEP1 FBN1 CACNA1G

2.06e-0419012658cb950effc449ae59a915132ecc079be54d1acfe
ToppCelldroplet-Tongue-nan-24m-Epithelial-filiform|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENC1 WNT9B FAM3D KIAA2012 NXPH4

2.06e-04190126586ab845a7fae2111c0b01e1aec235e19c4c0ef5c
DrugAC1Q5V97

IMPDH2 ADK CLCN1 GLS GLUD1 GLUD2

1.19e-07431246CID000000195
DrugAC1O3MP2

ADK GLS GLUD1 GLUD2

2.69e-07111244CID006332324
Drugalpha-ketoglutaramate

GLS GLUD1 GLUD2

6.28e-0741243CID000000048
Drug(-)-Adenosine 3',5'-cyclic monophosphate [60-92-4]; Up 200; 12.2uM; MCF7; HT_HG-U133A

GLIPR1 JADE2 INPP4A ITGAL EML3 NF1 PPP5C GZMK HERC3

1.36e-0619712493531_UP
DrugHyoscyamine (L) [101-31-5]; Up 200; 13.8uM; PC3; HT_HG-U133A

CLTCL1 SRD5A3 TRIM33 NF1 PPP5C DHRS9 LYPD3 HERC3 ACSL5

1.42e-0619812492108_UP
DrugAC1NRA4I

FASN GLUD1 GLUD2

1.56e-0651243CID005287695
Drugl-413

MB GLUD1 GLUD2

1.56e-0651243CID000012475
Drug3-aminopicolinate

GLS GLUD1 GLUD2

1.56e-0651243CID000073836
Drugdiazonium-1-H-tetrazole

MB GLUD1 GLUD2

3.12e-0661243CID000188312
DrugAC1L448Y

ADK GLUD1 GLUD2

3.12e-0661243CID000200389
Drugn-propionyl-CoA

BAAT MCCC1 FASN SLC27A1 GLUD1 GLUD2 SLC25A10 ACSL5

3.62e-061661248CID000001033
DrugCoA group

ACAT2 BAAT MCCC1 IRX4 FASN SLC35G3 SLC27A1 DHRS9 GLUD1 GLUD2 MTTP ACSL5

4.49e-0643312412CID000000317
Drugacetoacetate

ACAT2 MCCC1 FASN GLS GLUD1 GLUD2 PCK2

4.78e-061221247CID000000096
Drug1,5-AG

CFH GLUD1 GLUD2 SLC25A10 CD40 TNF PCK2 KIF11

7.14e-061821248CID000064960
Drugiminoglutarate

GLS GLUD1 GLUD2

8.66e-0681243CID000152649
DrugRapamycin; Down 200; 0.1uM; HL60; HT_HG-U133A

CLTCL1 PREPL EML3 ADK TELO2 GLS PPIP5K2 PCK2

1.27e-0519712481148_DN
DrugCarteolol hydrochloride [51781-21-6]; Down 200; 12.2uM; PC3; HT_HG-U133A

MB SMURF1 PEX1 EML3 PREX2 SVEP1 PPP5C HERC3

1.27e-0519712484096_DN
DrugAC1N4HBY

GLUD1 GLUD2 PCK2

1.29e-0591243CID004128835
Drugethanolamine-O-sulfate

FANCL F13A1 GLUD1 GLUD2 PRKCG

2.06e-05611245CID000070223
Drugo-diazoacetyl-L-serine

IMPDH2 ADK GLS GLUD1 GLUD2

2.23e-05621245CID000000830
Drugbenzamide riboside

IMPDH2 ADK GLUD1 GLUD2

2.35e-05311244CID000122749
Drugsulfoacetic acid

GLUD1 GLUD2 PCK2

2.52e-05111243CID000031257
Drugkievitone

MB GLUD1 GLUD2

2.52e-05111243CID000119269
Drugmalate

MCCC1 F13A1 SLC35G3 GLS GLUD1 GLUD2 SLC25A10 PCK2

2.73e-052191248CID000000525
DrugAC1L8NTU

CLTCL1 GZMK CD40 MTTP TNF KIR2DL2

2.81e-051081246CID000384608
Drugphenyltriethoxysilane

GLUD1 GLUD2

2.94e-0521242CID000013075
DrugG-3SH

GLUD1 GLUD2

2.94e-0521242CID000174237
Drugiodoacetyldiethylstilbestrol

GLUD1 GLUD2

2.94e-0521242CID006455327
Drugmethylmercuric bromide

GLUD1 GLUD2

2.94e-0521242CID000068175
Drug5-methylisophthalate

GLUD1 GLUD2

2.94e-0521242CID000068137
Drugx 1 s

GLUD1 GLUD2

2.94e-0521242CID000409694
DrugAC1O3Q5W

ADK GLUD1 GLUD2

3.35e-05121243CID006334250
Drugdioxinodehydroeckol

FASN SLC27A1 TNF

3.35e-05121243ctd:C550453
Drugcarbamoyl phosphate

IMPDH2 MCCC1 GLS GLUD1 GLUD2 PCK2

3.63e-051131246CID000000278
Drugrichter

F13A1 SACS GLUD1 GLUD2

5.36e-05381244CID003032626
DrugAC1Q68ZE

ACAT2 ADK FASN GLUD1 GLUD2

7.22e-05791245CID000000265
DrugAtorvastatin Calcium

MB ITGAL FASN CLCN1 CD40 MTTP TNF

7.30e-051861247ctd:D000069059
DrugAMP group

IMPDH2 BAAT MCCC1 ADK STRADA UBE2S PRKCG TGM7 TNF PCK2 DYNC1I1 ACSL5

7.82e-0557912412CID000000224
DrugScout

PPAN ENC1 FANCL

8.38e-05161243CID000048132
Drugmethionine sulfone

GLS GLUD1 GLUD2

8.38e-05161243CID000069961
DrugAC1L1A5E

GLS GLUD1 GLUD2

8.38e-05161243CID000000843
Drugnicotinamide ribose

IMPDH2 ADK FASN GLUD1 GLUD2

8.62e-05821245CID000000940
DrugNSC22419

IMPDH2 ADK

8.80e-0531242CID000078389
Druglenthionine

GLUD1 GLUD2

8.80e-0531242CID000067521
Drugmildiomycin

GLUD1 GLUD2

8.80e-0531242CID000125665
Drugmethoxyethylmercury

GLUD1 GLUD2

8.80e-0531242CID000115155
Drug4-methylumbelliferyl laurate

GLUD1 GLUD2

8.80e-0531242CID000600674
Drugmethylmercuric iodide

GLUD1 GLUD2

8.80e-0531242CID000067347
DrugNimodipine [66085-59-4]; Up 200; 9.6uM; MCF7; HT_HG-U133A

DMXL2 EML3 ADK TRMT2A PPP5C GLS NXPH4

9.20e-0519312475421_UP
Drugpioglitazone HCl; Down 200; 10uM; PC3; HT_HG-U133A

SRD5A3 VEZT OBSL1 TMEM104 F13A1 BUB1 HERC3

9.82e-0519512475977_DN
DrugAminopurine, 6-benzyl [1214-39-7]; Down 200; 17.8uM; MCF7; HT_HG-U133A

SRD5A3 VEZT INPP4A ENC1 PREX2 HPGD GLS

9.82e-0519512474748_DN
DrugBiperiden hydrochloride [1235-82-1]; Up 200; 11.4uM; MCF7; HT_HG-U133A

GLIPR1 ZSWIM8 DMXL2 VEZT OBSL1 SVEP1 GLS

9.82e-0519512473321_UP
Drugcarnitine

MB BAAT MCCC1 BHMT FASN SLC27A1 TNF PCK2

1.04e-042651248CID000000085
DrugPropafenone hydrochloride [34183-22-7]; Down 200; 10.6uM; MCF7; HT_HG-U133A

INPP4A SMURF1 TMEM104 IRX4 DZANK1 TRMT2A TELO2

1.05e-0419712475437_DN
DrugCorynanthine hydrochloride [66634-44-4]; Up 200; 10.2uM; MCF7; HT_HG-U133A

ITGA10 SVEP1 PPP5C HPGD GLS ELAPOR1 NXPH4

1.05e-0419712472786_UP
DrugNadide [53-84-9]; Down 200; 6uM; MCF7; HT_HG-U133A

ERCC6 VEZT TMEM104 PREX2 NF1 HOXD1 GLS

1.05e-0419712476091_DN
DrugC75; Up 200; 10uM; PC3; HT_HG-U133A

ZSWIM8 ITGA10 SVEP1 CRYAA NF1 HOXD1 INVS

1.05e-0419712476399_UP
DrugNomegestrol acetate [58652-20-3]; Down 200; 10.8uM; MCF7; HT_HG-U133A

GLIPR1 ERCC6 ITGA10 TMEM104 HOXD1 PPP5C BUB1

1.08e-0419812476525_DN
Drugaspirin, USP; Up 200; 100uM; PC3; HT_HG-U133A

CLTCL1 VEZT BAAT OBSL1 F13A1 NF1 PPP5C

1.08e-0419812474428_UP
DrugMegestrol acetate [595-33-5]; Down 200; 10.4uM; MCF7; HT_HG-U133A

ERCC6 INPP4A SMURF1 PEX1 NF1 GLS HERC3

1.08e-0419812476468_DN
Drugoxaloacetate

MCCC1 SLC35G3 GLS GLUD1 GLUD2 SLC25A10 PCK2

1.08e-041981247CID000000970
DrugTinidazole [19387-91-8]; Down 200; 16.2uM; MCF7; HT_HG-U133A

GLIPR1 SRD5A3 SMURF1 PEX1 EML3 NF1 GLS

1.11e-0419912473430_DN
DrugFlunixin meglumine [42461-84-7]; Down 200; 8.2uM; PC3; HT_HG-U133A

EDC3 PREX2 NF1 HPGD BUB1 LYPD3 HERC3

1.15e-0420012473713_DN
Drugalbizziin

GLS GLUD1 GLUD2

1.21e-04181243CID000092891
Drug2 pc

NF1 GLUD1 GLUD2

1.21e-04181243CID000440046
Drugphosphoribosylamine

IMPDH2 MCCC1 GLS

1.43e-04191243CID000000150
Drugpurpurin-18

TUBA4A GLUD1 GLUD2

1.43e-04191243CID005489047
DrugN-acetylglutamate

MCCC1 GLS GLUD1 GLUD2

1.47e-04491244CID000000185
Drugcitric acid

WDR81 BHMT FASN SLC35G3 GLS GLUD1 GLUD2 SLC25A10 PCK2

1.51e-043571249CID000000311
DrugNSC-7616

SLC35G3 GLUD1 GLUD2 PCK2

1.59e-04501244CID000000309
Drug5-amino-1-phenyltetrazole

IMPDH2 GLUD1 GLUD2

1.68e-04201243CID000021640
Druge511

GLUD1 GLUD2 NAV2

1.68e-04201243CID000024644
Drugmecobalamin

IMPDH2 BHMT CRYAA KIR2DL2

1.72e-04511244CID006436232
Drugmethyl benzoquate

GLUD1 GLUD2

1.75e-0441242CID000026383
Drugpentenoic acid

GLUD1 GLUD2

1.75e-0441242CID000012299
Drugureidoglycine

GLUD1 GLUD2

1.75e-0441242CID000439649
DrugIvin

GLUD1 GLUD2

1.75e-0441242CID000014083
Drug8-BDB-TADP

GLUD1 GLUD2

1.75e-0441242CID000130791
Drugcadina-3,9-diene

GLUD1 GLUD2

1.75e-0441242CID000010657
DrugAC1L9CUQ

GLUD1 GLUD2

1.75e-0441242CID000442451
DrugAC1L8X8C

IMPDH2 ADK

1.75e-0441242CID000409590
Drugluxabendazole

GLUD1 GLUD2

1.75e-0441242CID000072019
DrugNSC 125640

IMPDH2 ADK

1.75e-0441242CID000097467
DrugN-butylmaleimide

GLUD1 GLUD2

1.75e-0441242CID000239780
Drugalpha-methylglutamate

GLUD1 GLUD2

1.75e-0441242CID000095440
Drug2b E2

GLUD1 GLUD2

1.75e-0441242CID005327076
DrugAC1L1AH5

BAAT FASN SLC27A1 GLUD1 GLUD2 SLC25A10 ACSL5

1.80e-042151247CID000000986
DrugTween 20

PPAN GLUD1 GLUD2 MTTP PCK2

2.00e-04981245CID000443314
DrugNSC-93090

LAMA1 FTSJ1 FASN TNF

2.15e-04541244CID000261166
DrugI-Q-S

IMPDH2 LAMA1 FBN1 NF1 PRKCG TNF

2.16e-041561246CID000003540
Drugpolyethylene glycol

FANCL ADK GLS GLUD1 GLUD2 MTTP PRKCG PCK2

2.38e-042991248CID000000174
Drugtaxol

LAMA1 OLFM4 PKD1L3 ITGAL TUBA4A FASN BUB1 PRKCG TNF DYNC1I1 KIF11

2.49e-0456012411CID000004666
DrugAC1Q68Z5

ACAT2 MCCC1 ADK FASN SLC35G3 GLS GLUD1 GLUD2 PCK2

2.69e-043861249CID000000181
DrugAICAR monophosphate

IMPDH2 ADK FASN SLC27A1 GLS PCK2

2.73e-041631246CID000000200
Drug1,2-cyclohexanedione

MB MCCC1 GLUD1 GLUD2

2.83e-04581244CID000013006
DrugN V A

WDR81 F13A1 GLUD1 GLUD2

2.83e-04581244CID000000824
Drugbathocuproine

GLUD1 GLUD2

2.91e-0451242CID000065149
Drugisosteviol lactone

GLUD1 GLUD2

2.91e-0451242CID000401559
Drug1-pheg

GLUD1 GLUD2

2.91e-0451242CID000152041
DrugAC1O4QHN

CFH BHMT

2.91e-0451242CID006398424
DiseaseProfound Mental Retardation

SRD5A3 INPP4A LAMA1 ADK FASN NF1 PRKCG CACNA1G

1.29e-071391238C0020796
DiseaseMental deficiency

SRD5A3 INPP4A LAMA1 ADK FASN NF1 PRKCG CACNA1G

1.29e-071391238C0917816
DiseaseMental Retardation, Psychosocial

SRD5A3 INPP4A LAMA1 ADK FASN NF1 PRKCG CACNA1G

1.29e-071391238C0025363
DiseaseEndogenous Hyperinsulinism

FBN1 GLUD1 CD40 TNF

4.00e-06261234C1257963
DiseaseExogenous Hyperinsulinism

FBN1 GLUD1 CD40 TNF

4.00e-06261234C1257964
DiseaseCompensatory Hyperinsulinemia

FBN1 GLUD1 CD40 TNF

4.00e-06261234C1257965
DiseaseHyperinsulinism

FBN1 GLUD1 CD40 TNF

5.45e-06281234C0020459
DiseaseIntellectual Disability

SRD5A3 INPP4A LAMA1 PREPL ADK FASN NF1 SACS PRKCG CACNA1G

1.88e-0544712310C3714756
Diseasefascioliasis (biomarker_via_orthology)

GLUD1 GLUD2

5.16e-0531232DOID:885 (biomarker_via_orthology)
DiseaseLiposarcoma, Pleomorphic

FASN NF1

1.03e-0441232C0205825
DiseaseFanconi Anemia

FANCL BRCA2 TNF

1.52e-04251233C0015625
Diseasepulmonary embolism (is_implicated_in)

F13A1 BHMT

1.71e-0451232DOID:9477 (is_implicated_in)
DiseaseMalignant Glioma

DMXL1 NF1 BRCA2 TNF

2.13e-04701234C0555198
Diseasemixed gliomas

DMXL1 NF1 BRCA2 TNF

2.13e-04701234C0259783
Diseaseliposarcoma

FASN NF1

2.56e-0461232C0023827
DiseaseLiposarcoma, well differentiated

FASN NF1

2.56e-0461232C1370889
DiseaseLiposarcoma, Dedifferentiated

FASN NF1

2.56e-0461232C0205824
Diseasechildhood absence epilepsy (biomarker_via_orthology)

GLUD1 GLUD2

2.56e-0461232DOID:1825 (biomarker_via_orthology)
Diseasetemporal lobe epilepsy (biomarker_via_orthology)

ADK GLUD1 GLUD2

2.92e-04311233DOID:3328 (biomarker_via_orthology)
Diseaseobsolete_interleukin-1 alpha measurement

CFH GRID2IP

3.57e-0471232EFO_0802653
DiseaseNephroblastoma

GLIPR1 DIS3L2 BRCA2

4.56e-04361233C0027708
Diseaseanterior uveitis (is_implicated_in)

CFH TNF

4.75e-0481232DOID:1407 (is_implicated_in)
DiseaseGlioma

DMXL1 NF1 BRCA2 TNF

4.90e-04871234C0017638
DiseaseMalignant neoplasm of breast

ERCC6 TRAPPC8 CRYAA FASN NF1 CLCN1 TRMT2A DAZAP1 BRCA2 CD40 ELAPOR1 TNF HERC2

5.57e-04107412313C0006142
Diseasechoroid plexus volume measurement

DEPTOR PLXNA4

6.09e-0491232EFO_0010293
DiseaseInherited neuropathies

SACS MTTP PRKCG

6.24e-04401233C0598589
Diseasehigh grade glioma (is_implicated_in)

NF1 BRCA2 TNF

7.21e-04421233DOID:3070 (is_implicated_in)
DiseaseAsthma, Occupational

TNF HERC2

7.59e-04101232C0264423
DiseaseFuchs endothelial corneal dystrophy

CFH GATD1

7.59e-04101232Orphanet_98974
DiseaseSecondary Trigeminal Neuralgia

PRKCG TNF

1.11e-03121232C0393787
DiseaseTrigeminal Neuralgia, Idiopathic

PRKCG TNF

1.11e-03121232C0393786
Diseasehyperinsulinism (is_implicated_in)

GLUD1 MTTP

1.11e-03121232DOID:2018 (is_implicated_in)
DiseaseTrigeminal Neuralgia

PRKCG TNF

1.11e-03121232C0040997
DiseaseKawasaki disease (is_implicated_in)

CD40 TNF

1.11e-03121232DOID:13378 (is_implicated_in)
DiseaseSarcoma, Spindle Cell

NF1 TNF

1.52e-03141232C0205945
DiseaseSarcoma, Epithelioid

NF1 TNF

1.52e-03141232C0205944
Diseasenephroblastoma (is_implicated_in)

DIS3L2 BRCA2

1.52e-03141232DOID:2154 (is_implicated_in)
DiseaseFanconi anemia

FANCL BRCA2

1.52e-03141232cv:C0015625
Diseaseglucose-dependent insulinotropic peptide measurement, glucose tolerance test

F13A1 HOXD1

1.52e-03141232EFO_0004307, EFO_0008464
Diseasebeta-amyloid 1-42 measurement, cerebrospinal fluid biomarker measurement

HLX ANKRD50

1.52e-03141232EFO_0004670, EFO_0006794
Diseasehepatic encephalopathy (biomarker_via_orthology)

GLUD1 GLUD2

1.75e-03151232DOID:13413 (biomarker_via_orthology)
DiseaseC-X-C motif chemokine 6 measurement

CFH TELO2

1.99e-03161232EFO_0008059
Diseasesystemic lupus erythematosus (is_implicated_in)

CFH CD40 TNF

2.23e-03621233DOID:9074 (is_implicated_in)
Diseaseperinatal necrotizing enterocolitis (biomarker_via_orthology)

CD40 TNF

2.25e-03171232DOID:8677 (biomarker_via_orthology)
Diseaseovarian neoplasm

ERCC6 FASN HOXD1 BRCA2

2.43e-031341234C0919267
DiseaseAge-related macular degeneration

CFH ERCC6

2.52e-03181232cv:C0242383
DiseaseBone marrow hypocellularity

FANCL BRCA2

2.52e-03181232C1855710
DiseaseMalignant neoplasm of ovary

ERCC6 FASN HOXD1 BRCA2

2.64e-031371234C1140680
DiseaseColorectal Carcinoma

ERCC6 LAMA1 PREX2 NF1 HOXD1 SACS BUB1 TNF ACSL5

2.76e-037021239C0009402
Diseasefamilial hyperlipidemia (biomarker_via_orthology)

SLC27A1 MTTP

2.81e-03191232DOID:1168 (biomarker_via_orthology)
Diseasemyelodysplastic syndrome (is_marker_for)

CD40 TNF

3.12e-03201232DOID:0050908 (is_marker_for)
Diseasecoagulation factor measurement

CFH F13A1

3.12e-03201232EFO_0004634
DiseaseSarcoma

NF1 TNF

3.44e-03211232C1261473
Diseaseserum albumin measurement

CFH ZNF577 WDR81 HLX PKD1L3 TEX35 SVEP1 SBF2

3.44e-035921238EFO_0004535
DiseaseHepatitis

ANKRD50 NAV2

3.77e-03221232HP_0012115
DiseaseCarcinoma of lung

ERCC6 BRCA2

4.12e-03231232C0684249
Diseasevitronectin measurement

CFH SEZ6

4.12e-03231232EFO_0021843

Protein segments in the cluster

PeptideGeneStartEntry
VKAGASIIGVNCHFD

BHMT

206

Q93088
HPKVFGSGVGVVSVC

BAAT

221

Q14032
QPHKAATFFGCIGID

ADK

96

P55263
GCVNKSTHEFKPQSG

BUB1

406

O43683
IPNTDRGHCGKTFAI

B3GLCT

316

Q6Y288
GPLICKGVFHAIVSG

GZMK

216

P49863
FCGEPAHSLLVKGKV

APCDD1L

96

Q8NCL9
EQAGAQALIHFGPAC

DPH2

96

Q9BQC3
VAALCVPASKGHASV

ANKRD50

716

Q9ULJ7
KQSGISPVHCAAAGA

ASB14

311

A6NK59
FVQGKSIDVACHPGY

CFH

406

P08603
FTTANAHFKVGCPVL

DMXL2

1886

Q8TDJ6
GVFHCAVETAKLGPL

SLC25A10

236

Q9UBX3
CKPLADGNFKVGVHI

DIS3L2

396

Q8IYB7
KSNKIFVGGIPHNCG

DAZAP1

111

Q96EP5
VLTGAVNPGDHCFSV

DMXL1

6

Q9Y485
IFAGTGSDVQTPKCH

ERCC6

1021

Q03468
NKAVTCAAHLPGAAA

ARIH2OS

41

Q8N7S6
GVPGAKESRAFNCHV

NXPH4

221

O95158
PCGAGRVHKTTALVF

INSYN2A

161

Q6ZSG2
VCEAKLGFVPAGASA

IRX4

346

P78413
QFAFHVGLPAKSGVA

GLS

471

O94925
DIVTIGAPAAHCQGF

INPP4A

356

Q96PE3
SFHNGVAAGLKIAPA

ANAPC1

1136

Q9H1A4
VKHQDSGALVGFSCP

OBSL1

686

O75147
AHECRFSAGPKVNGT

KIR2DL2

166

P43627
FAFKICSGAANVVGP

FAM3D

66

Q96BQ1
CPKVSGFDALSNGAH

GLIPR1

156

P48060
KPSFCIADILHAGVG

HLX

41

Q14774
CLKASADGHPGAFQT

HOXD1

166

Q9GZZ0
ACLVPAAGGSQKLFS

SBF2

161

Q86WG5
KHIVGIACGPAQSFA

HERC2

761

O95714
VKEVACGGNHSVFLL

HERC3

36

Q15034
VDCSSIGGVPFFQHK

KIF11

1001

P52732
FEAKARHGFCGIPIT

IMPDH2

131

P12268
FQVTQGTGPELHACK

ELAPOR1

36

Q6UXG2
VCFARFHPNLVVGGT

DYNC1I1

346

O14576
VHQACYGILKVPTGS

JADE2

226

Q9NQC1
DFVKCLHSVGQPLTG

PCK2

206

Q16822
AKPSQHAGFVEICVA

PLXNA4

921

Q9HCM2
AIPIVGQVFQSHCKG

MTTP

286

P55157
CGKHQAVGTSPQRAA

TPO

896

P07202
CVSLSGHVQAGIFKP

PINLYP

151

A6NC86
HITFCGGAFPNRKAD

KIAA2012

321

Q0VF49
GPASVQAIKHGHVCF

F13A1

411

P00488
EAVAICKGFLTKHPG

PRKCG

581

P05129
TVALLCGPHVKGAQG

EDC3

336

Q96F86
AVCGFEAFINGKHIV

PARP4

666

Q9UKK3
PHNKGCVAPTAGLAA

LYPD3

321

O95274
KAGVVIHCNHRIPFG

SRD5A3

231

Q9H8P0
SESKPICAVGHGVAA

GATD1

116

Q8NB37
PCFVLEVAKGSSAHA

GRID2IP

26

A4D2P6
GTHPCLAAATQTGKV

BBS2

26

Q9BXC9
AVGGQVPSACSHKQL

BRCA2

2526

P51587
TNCSAGEHNPFKGAI

CACNA1G

321

O43497
QGTVAFKKLCPHGRG

FBN1

2381

P35555
AHACVTGKPISQGGI

GLUD1

251

P00367
GFVVRGSKPCHIQAV

DEPTOR

341

Q8TB45
TSGHVGVPLACNYVK

ACSL5

461

Q9ULC5
VAKTSAAQAIHPGCG

MCCC1

116

Q96RQ3
LCSVGHPVFQTGAKV

ITGA10

876

O75578
VGLHVGALFPVCAAF

CDH26

611

Q8IXH8
CHAVASGNKLYVVGG

ENC1

531

O14682
GLCADFHPSGAVVAV

EML3

641

Q32P44
FCGPKIQTGLDATHA

CRYAA

141

P02489
QSPGFAHVSGQKCLT

DZANK1

181

Q9NVP4
HSGQCPAAIVGGINV

FASN

176

P49327
GVVRPLKCTVFHGAQ

FASN

1821

P49327
AFGVHVSCIEPGLFK

DHRS9

196

Q9BPW9
GLPVHINGCFAVTSN

SACS

1881

Q9NZJ4
LSNGGQVFLKPCSHV

PEX1

86

O43933
AHACVTGKPISQGGI

GLUD2

251

P49448
SKGQSACVHFRPNEG

INVS

696

Q9Y283
AQQPVYCASKHGIVG

HPGD

146

P15428
CLKVPVALAGHTGEF

STK11IP

811

Q8N1F8
GYAVTKAHPALVCAV

SLC35G5

271

Q96KT7
GITACELANGHVPFK

STRADA

266

Q7RTN6
GYAVTKAHPALVCAV

SLC35G3

271

Q8N808
VGASGQRPVFCPVHK

TRIM33

266

Q9UPN9
KGGTCAVAAPFDTVH

TRMT2A

266

Q8IZ69
RKHPGCGNIVTFAQF

SLC35B4

26

Q969S0
CFFLGADHVVKPLGI

FANCL

251

Q9NW38
VAHGGRCVTVFSAPN

PPP5C

436

P53041
PAVKVTHFKGCLGEA

LAMA1

2261

P25391
SKLFCHLFVGSQPGE

SH2D5

116

Q6ZV89
VPCHVKGSVALQVGD

NICN1

6

Q9BSH3
VLCANHTEPVKGFLG

NAV2

2276

Q8IVL1
CPFHSLNNVTKAGEG

PKD1L3

356

Q7Z443
VSFVSQVLGKACVHG

TELO2

211

Q9Y4R8
CNVSSPIFKAGHSVA

ITGAL

861

P20701
TFSCKEGHVLQGPSV

SVEP1

2346

Q4LDE5
GSAVQYSCKPGHILA

SVEP1

2736

Q4LDE5
CGHGGVVNISKPSVV

OLFM4

246

Q6UX06
PFAKIVVDGSGQCHS

SMURF1

36

Q9HCE7
FCFAVRNPTGGKLHI

CLTCL1

216

P53675
KEGPFVHIASICAAV

CLCN1

231

P35523
GYAVTKAHPALVCAV

SLC35G4

271

P0C7Q5
IFGHVLAAGCGQNPV

ACAT2

56

Q9BWD1
GKVGSCGFNSRILPH

SLC27A1

401

Q6PCB7
KDCVAVAGPLGVTHF

PPAN

71

Q9NQ55
GAAHSQICPGFVIQS

ZNF577

86

Q9BSK1
LAFGCGVSNKHRSPF

TMEM104

451

Q8NE00
SPVVACGPHGASFLK

UNC5CL

161

Q8IV45
CGHASAVAVTKAFPL

YJEFN3

96

A6XGL0
TLHKAVQGCGAHPAI

NF1

446

P21359
TIHFSCAPGYVLKGQ

SEZ6

861

Q53EL9
EACIKTLHGQGFSQP

PREPL

536

Q4J6C6
TVAAAAGLHPGQCII

PREX2

706

Q70Z35
AHPSNIYKVEGGCLT

TSPAN11

196

A1L157
AAVPAGKCSQHQGLS

nan

101

Q6ZVQ6
CIIQVLQSKHPGDFG

MB

111

P02144
YNHLVSVGCSGIKPD

ZNF630

41

Q2M218
TKIFHPNVGANGEIC

UBE2S

81

Q16763
NIATHVLKPGGCFVA

FTSJ1

141

Q9UET6
HQFCVGAAKGVLSPF

ZSWIM8

1716

A7E2V4
GQAFVHVAVAGGLCA

TMEM187

6

Q14656
KACFVHTGVYNLGTP

TRAPPC8

1391

Q9Y2L5
KQNPTVGSHCAGLFS

PPIP5K2

1051

O43314
TLVSAACPFNKAGQH

VEZT

236

Q9HBM0
TAAAPAQGGAHLKQC

WNT9B

41

O14905
FCAQALLHGGGTQKP

TGM7

531

Q96PF1
HQEARGPSFKICVGF

SPAG11A

76

Q6PDA7
ASGVNGAPCALHKKT

TEX35

146

Q5T0J7
GSPAACKHFIENQGL

ZYG11A

546

Q6WRX3
LQSFPGHSGAVKCVA

WDR81

1641

Q562E7
SQVLFKGQGCPSTHV

TNF

136

P01375
LHRSCSPGFGVKQIA

CD40

121

P25942
TFFCETGAGKHVPRA

TUBA4A

51

P68366
LPKAVHSAAATVCGG

KLHL29

716

Q96CT2