Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF705A ZNF154 ZNF705EP ZNF678 ZNF596 ZNF641 ZNF256 ZSCAN9 ZNF480 ZNF705B ZNF236 ZNF491 ZNF705D ZNF304	3.15e-05	1412	57	14	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF705A ZNF154 ZNF705EP ZNF678 ZNF596 ZNF641 ZNF256 ZSCAN9 ZNF480 ZNF705B ZNF236 ZNF491 ZNF705D ZNF304	4.52e-05	1459	57	14	GO:0000977
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	TRIML1 RNF125 TRIM56 TRIM49B TRIM5 TRIM51G	6.54e-04	372	57	6	GO:0061630
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	TRIML1 RNF125 TRIM56 TRIM49B TRIM5 TRIM51G	9.29e-04	398	57	6	GO:0061659
Domain	Znf_C2H2	ZNF705A RNF125 ZNF154 ZNF678 ZNF596 ZNF641 ZNF256 ZSCAN9 ZNF480 ZNF233 ZNF705B ZNF236 ZNF491 ZNF705D ZNF304	9.00e-09	805	56	15	IPR007087
Domain	ZnF_C2H2	ZNF705A RNF125 ZNF154 ZNF678 ZNF596 ZNF641 ZNF256 ZSCAN9 ZNF480 ZNF233 ZNF705B ZNF236 ZNF491 ZNF705D ZNF304	9.47e-09	808	56	15	SM00355
Domain	zf-C2H2	ZNF705A ZNF154 ZNF678 ZNF596 ZNF641 ZNF256 ZSCAN9 ZNF480 ZNF233 ZNF705B ZNF236 ZNF491 ZNF705D ZNF304	1.13e-08	693	56	14	PF00096
Domain	ZINC_FINGER_C2H2_2	ZNF705A ZNF154 ZNF678 ZNF596 ZNF641 ZNF256 ZSCAN9 ZNF480 ZNF233 ZNF705B ZNF236 ZNF491 ZNF705D ZNF304	4.58e-08	775	56	14	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF705A ZNF154 ZNF678 ZNF596 ZNF641 ZNF256 ZSCAN9 ZNF480 ZNF233 ZNF705B ZNF236 ZNF491 ZNF705D ZNF304	4.73e-08	777	56	14	PS00028
Domain	Znf_C2H2-like	ZNF705A RNF125 ZNF154 ZNF596 ZNF641 ZNF256 ZSCAN9 ZNF480 ZNF233 ZNF705B ZNF236 ZNF491 ZNF705D ZNF304	6.38e-08	796	56	14	IPR015880
Domain	-	ZNF705A ZNF154 ZNF596 ZNF641 ZNF256 ZSCAN9 ZNF480 ZNF233 ZNF705B ZNF236 ZNF491 ZNF705D ZNF304	7.73e-08	679	56	13	3.30.160.60
Domain	KRAB	ZNF705A ZNF154 ZNF596 ZNF641 ZNF256 ZNF480 ZNF233 ZNF705B ZNF705D ZNF304	9.61e-08	358	56	10	PS50805
Domain	KRAB	ZNF705A ZNF154 ZNF596 ZNF641 ZNF256 ZNF480 ZNF233 ZNF705B ZNF705D ZNF304	9.61e-08	358	56	10	PF01352
Domain	Znf_C2H2/integrase_DNA-bd	ZNF705A ZNF154 ZNF596 ZNF641 ZNF256 ZSCAN9 ZNF480 ZNF233 ZNF705B ZNF236 ZNF491 ZNF705D ZNF304	9.96e-08	694	56	13	IPR013087
Domain	KRAB	ZNF705A ZNF154 ZNF596 ZNF641 ZNF256 ZNF480 ZNF233 ZNF705B ZNF705D ZNF304	1.27e-07	369	56	10	SM00349
Domain	KRAB	ZNF705A ZNF154 ZNF596 ZNF641 ZNF256 ZNF480 ZNF233 ZNF705B ZNF705D ZNF304	1.31e-07	370	56	10	IPR001909
Domain	RING	TRIML1 RNF125 TRIM56 BAZ1B TRIM49B TRIM5	2.95e-04	305	56	6	SM00184
Domain	-	PIKFYVE TRIML1 RNF125 TRIM56 BAZ1B TRIM49B TRIM5	3.71e-04	449	56	7	3.30.40.10
Domain	Znf_RING	TRIML1 RNF125 TRIM56 BAZ1B TRIM49B TRIM5	4.21e-04	326	56	6	IPR001841
Domain	Znf_RING/FYVE/PHD	PIKFYVE TRIML1 RNF125 TRIM56 BAZ1B TRIM49B TRIM5	4.24e-04	459	56	7	IPR013083
Domain	BBOX	TRIM56 TRIM49B TRIM5	1.16e-03	69	56	3	SM00336
Domain	Butyrophylin	TRIML1 TRIM49B TRIM5	1.21e-03	70	56	3	IPR003879
Domain	zf-B_box	TRIM56 TRIM49B TRIM5	1.32e-03	72	56	3	PF00643
Domain	Znf_RING_CS	TRIML1 RNF125 TRIM56 TRIM5	1.44e-03	163	56	4	IPR017907
Domain	Znf_C3HC4_RING-type	TRIML1 RNF125 TRIM56 TRIM5	1.76e-03	172	56	4	IPR018957
Domain	ZF_RING_1	TRIML1 RNF125 TRIM56 TRIM49B TRIM5	1.77e-03	291	56	5	PS00518
Domain	ZF_BBOX	TRIM56 TRIM49B TRIM5	1.78e-03	80	56	3	PS50119
Domain	Znf_B-box	TRIM56 TRIM49B TRIM5	1.85e-03	81	56	3	IPR000315
Domain	ZF_RING_2	TRIML1 RNF125 TRIM56 TRIM49B TRIM5	1.96e-03	298	56	5	PS50089
Domain	SPRY	TRIML1 TRIM49B TRIM5	2.26e-03	87	56	3	SM00449
Domain	zf-C2H2_6	ZNF154 ZNF256 ZSCAN9 ZNF480 ZNF236	2.46e-03	314	56	5	PF13912
Domain	SPRY	TRIML1 TRIM49B TRIM5	2.82e-03	94	56	3	PF00622
Domain	SPRY_dom	TRIML1 TRIM49B TRIM5	2.82e-03	94	56	3	IPR003877
Domain	B30.2/SPRY	TRIML1 TRIM49B TRIM5	2.91e-03	95	56	3	IPR001870
Domain	B302_SPRY	TRIML1 TRIM49B TRIM5	2.91e-03	95	56	3	PS50188
Domain	ConA-like_dom	TRIML1 CELSR3 TRIM49B TRIM5	4.19e-03	219	56	4	IPR013320
Domain	zf-C3HC4	TRIML1 RNF125 TRIM56 TRIM5	4.47e-03	223	56	4	PF00097
Domain	Znf-RING_LisH	TRIM56 TRIM5	4.66e-03	34	56	2	IPR027370
Domain	zf-RING_UBOX	TRIM56 TRIM5	4.66e-03	34	56	2	PF13445
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF705A ZNF154 ZNF705EP ZNF678 ZNF596 ZNF641 ZNF256 INTS11 ZNF480 ZNF233 GEM ZNF705D ZNF304	9.68e-05	1387	41	13	M734
Pubmed	High Expression of NEK2 and PIM1, but Not PIM3, Is Linked to an Aggressive Phenotype of Bronchopulmonary Neuroendocrine Neoplasms.	PIM3 NEK2	8.48e-06	3	59	2	32504181
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PIKFYVE PIM3 BMP8B TNRC18 MDN1 CELSR3 VPS39 INTS11 KCNQ2 ZNF236	1.54e-05	1105	59	10	35748872
Pubmed	Role of the Rho GTPase-activating protein RICS in neurite outgrowth.	ARHGAP32 NFKBIE	1.69e-05	4	59	2	16716191
Pubmed	Identifying key m6A-methylated lncRNAs and genes associated with neural tube defects via integrative MeRIP and RNA sequencing analyses.	ZNF236 HMG20A	5.91e-05	7	59	2	36482889
Pubmed	DNA sequence and analysis of human chromosome 8.	HGH1 ZNF596 ZNF705B	7.60e-05	48	59	3	16421571
Pubmed	Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS.	PIKFYVE PLP1	1.01e-04	9	59	2	25754822
Pubmed	Gene expression in the developing mouse retina by EST sequencing and microarray analysis.	FZD5 TLE3 KCNQ2 TRIM5	1.02e-04	142	59	4	11812828
Pubmed	Mapping of multiple mouse loci related to the farnesyl pyrophosphate synthetase gene.	HAL PLP1	1.26e-04	10	59	2	8499655
Pubmed	Identification of a genomic reservoir for new TRIM genes in primate genomes.	TRIM49B TRIM51G	4.75e-04	19	59	2	22144910
Pubmed	TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.	TRIM56 TRIM5	5.82e-04	21	59	2	18248090
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ARHGAP32 VPS39 SUN1	6.87e-04	101	59	3	9872452
Pubmed	Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.	TRIML1 RNF125 TRIM5	7.69e-04	105	59	3	22493164
Pubmed	The functional interactome landscape of the human histone deacetylase family.	TNRC18 MDN1 BAZ1B HMG20A	1.48e-03	289	59	4	23752268
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	NPHS1 ZNF154 ZNF256 ZNF480 ZNF233 BCL3 KLC3 ZNF304	1.38e-04	1192	59	8	chr19q13
Cytoband	20q13.3	TNFRSF6B KCNQ2	3.04e-04	20	59	2	20q13.3
Cytoband	11p11.12	TRIM49B TRIM51G	1.35e-03	42	59	2	11p11.12
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	ZNF596 ZNF705B ZNF705D	3.44e-03	234	59	3	chr8p23
Cytoband	19q13.4	ZNF154 ZNF304	4.69e-03	79	59	2	19q13.4
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF705A ZNF154 ZNF678 ZNF596 ZNF641 ZNF256 ZSCAN9 ZNF480 ZNF233 ZNF705B ZNF236 ZNF491 ZNF705D ZNF304	1.58e-09	718	46	14	28
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM56 TRIM49B TRIM5 TRIM51G	9.86e-05	95	46	4	59
GeneFamily	Ring finger proteins	TRIML1 RNF125 TRIM56 TRIM49B TRIM5	6.46e-04	275	46	5	58
Disease	ulcerative colitis	TNRC18 CELSR3 INTS11 TNFRSF6B	2.68e-03	335	51	4	EFO_0000729
Disease	Alzheimer disease, polygenic risk score	PRSS12 BCL3 KLC3 TRIM51G HMG20A	3.36e-03	586	51	5	EFO_0030082, MONDO_0004975
Disease	total cholesterol measurement, diastolic blood pressure, triglyceride measurement, systolic blood pressure, hematocrit, ventricular rate measurement, glucose measurement, body mass index, high density lipoprotein cholesterol measurement	BAZ1B BCL3	3.54e-03	51	51	2	EFO_0004340, EFO_0004348, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928
Disease	total cholesterol measurement, hematocrit, stroke, ventricular rate measurement, body mass index, atrial fibrillation, high density lipoprotein cholesterol measurement, coronary artery disease, diastolic blood pressure, triglyceride measurement, systolic blood pressure, heart failure, diabetes mellitus, glucose measurement, mortality, cancer	BAZ1B BCL3	6.38e-03	69	51	2	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004340, EFO_0004348, EFO_0004352, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928, MONDO_0004992

Protein segments in the cluster

Peptide	Gene	Start	Entry
EHRDHSAHCQAVNEK	ABCA9	151	Q8IUA7
RFNHHCKDHTVSGDE	BAZ1B	936	Q9UIG0
SHRNRHSATPEDHCR	GEM	41	P55040
DHGQRVTCRAHSAEL	NPHS1	616	O60500
RHNCRHSEDAGVICD	PRSS12	586	P56730
SSDCHPRRHSHEDQE	LNP1	61	A1A4G5
TGNHCVRINNHEHTD	MDN1	1101	Q9NU22
ECHRRSDGGHTVLHR	NEK2	126	P51955
EHQLRFTCRVHLHDT	INTS11	506	Q5TA45
SHRQDAARQATHDHE	HMG20A	191	Q9NP66
HGDTALHVACQRQHL	NFKBIE	326	O00221
THQVDHSDRCRHFIG	FANCM	746	Q8IYD8
HSPEDSREHVDRHGC	KCNQ2	671	O43526
RQALEDLERSSGHCH	KLC3	231	Q6P597
EHRAHQEASHRQFCE	ARHGAP32	1876	A7KAX9
HSCGHEGHLRETAEI	GTSCR1	21	Q86UQ5
EIQETCDAHHRGHSR	FRG2	136	Q64ET8
TRRANAEPCGHSIHH	PIKFYVE	1351	Q9Y2I7
VGHASVACSREHNHI	FZD5	291	Q13467
HHPSEIAESHRFCDR	HAL	376	P42357
SHFRECINHGDLNDH	HYKK	216	A2RU49
SQQHQHRHSGHEREE	DNAJB14	226	Q8TBM8
HREHEDTRDLARVHG	CCDC166	256	P0CW27
DEGRHLGSRHCQTLH	CACNA1I	496	Q9P0X4
TARDCELVHRNGSHA	CELSR3	2496	Q9NYQ7
DVHGSHGRQVCRRHE	BMP8B	291	P34820
LDRHGQTAAHLACEH	BCL3	201	P20749
RCHHSTSDNELEGRL	PRAMEF13	241	Q5VWM6
VGTLRNCCFEHRHHE	HGH1	221	Q9BTY7
ARHSQGHCGHLEVLE	FYB2	456	Q5VWT5
LCERSQEHRGHHTFL	TRIM5	116	Q9C035
LAAQHHHSRAEEEAA	TNRC18	526	O15417
ECSHLTRHRRIHTGE	ZNF678	276	Q5SXM1
QCSHLRRHEKTHTGE	ZNF705A	211	Q6ZN79
HCSHLRQHERSHNGE	ZNF596	346	Q8TC21
DSLLDHCITHHRSER	RNF125	151	Q96EQ8
QRVHTGVRSHECHEC	ZNF256	426	Q9Y2P7
AAVRHCHSCGVVHRD	PIM3	156	Q86V86
QCSHLRRHEKTHTGE	ZNF705EP	211	A8MWA4
HHELDHRERESSANN	TLE3	186	Q04726
GANRVHLSSEAEEHH	TRIML1	121	Q8N9V2
SRNSHLAEHCRIHTG	ZNF480	241	Q8WV37
QCSHLRRHEKTHTGE	ZNF705B	211	P0CI00
QCSHLRRHEKTHTGE	ZNF705D	211	P0CH99
SNSQEHRNHRHCPTE	TRIM51G	116	A0A3B3IT33
DHCVRQRIAHQHDDH	ZNF233	211	A6NK53
CVSSFHRHERTHAGE	ZNF491	366	Q8N8L2
EEHRQELAGTRQHAC	ZNF236	141	Q9UL36
VRHQKAHTGERAHEC	ZNF304	631	Q9HCX3
QHRRVHTAVRPHECD	ZNF154	206	Q13106
SLSGQCHHHGENLRE	SUN1	371	O94901
HQRSHTGERPHQCIE	ZSCAN9	356	O15535
SSSQEHRDHRHCPIE	TRIM49B	116	A6NDI0
HRDHRHCPIESAAEE	TRIM49B	121	A6NDI0
CADGHRCTRQTHTHR	TRIM56	131	Q9BRZ2
RLENNHCHIEESEHV	VPS39	481	Q96JC1
GEREEEARACHATHN	TNFRSF6B	96	O95407
CNSHLASHQRVHAEG	ZNF641	331	Q96N77
SRSECHFVGCHHSRD	LYPD6B	111	Q8NI32
SRGQHQAHSLERVCH	PLP1	126	P60201