Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiongrowth factor binding

ERBB3 ERBB4 BMPR2 IGF1R NLRP7

3.32e-06156305GO:0019838
GeneOntologyMolecularFunctionneuregulin receptor activity

ERBB3 ERBB4

6.54e-063302GO:0038131
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

ERBB3 ERBB4 BMPR2 IGF1R

7.70e-0685304GO:0019199
GeneOntologyMolecularFunctionneuregulin binding

ERBB3 ERBB4

3.26e-056302GO:0038132
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

ERBB3 ERBB4 IGF1R

1.26e-0465303GO:0004714
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

ERBB3 ERBB4 IGF1R

1.32e-03145303GO:0004713
GeneOntologyMolecularFunctionprotein kinase activity

ERBB3 ERBB4 BMPR2 IGF1R MTOR

1.84e-03600305GO:0004672
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

ERBB3 ERBB4 BMPR2 PTDSS2 IGF1R MTOR

2.38e-03938306GO:0016772
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

ERBB3 ERBB4 BMPR2 IGF1R MTOR

3.79e-03709305GO:0016773
GeneOntologyMolecularFunctionkinase activity

ERBB3 ERBB4 BMPR2 IGF1R MTOR

5.21e-03764305GO:0016301
GeneOntologyBiologicalProcesscholangiocyte apoptotic process

IGF1R MTOR

5.72e-063292GO:1902488
GeneOntologyBiologicalProcessnegative regulation of cholangiocyte apoptotic process

IGF1R MTOR

5.72e-063292GO:1904193
GeneOntologyBiologicalProcessregulation of cholangiocyte apoptotic process

IGF1R MTOR

5.72e-063292GO:1904192
GeneOntologyBiologicalProcesspositive regulation of kinase activity

ERBB3 ERBB4 IGF1R FGD2 MTOR GPR39

1.79e-05405296GO:0033674
GeneOntologyBiologicalProcesspositive regulation of transferase activity

ERBB3 ERBB4 IGF1R FGD2 MTOR GPR39

5.20e-05490296GO:0051347
GeneOntologyBiologicalProcesspositive regulation of phosphorylation

ERBB3 ERBB4 BMPR2 IGF1R FGD2 MTOR GPR39

8.11e-05780297GO:0042327
GeneOntologyBiologicalProcesscardiac muscle tissue development

ERBB3 ERBB4 BMPR2 DSP MTOR

8.44e-05327295GO:0048738
GeneOntologyBiologicalProcessstriated muscle tissue development

ERBB3 ERBB4 BMPR2 DSP MTOR

1.15e-04349295GO:0014706
GeneOntologyBiologicalProcesspositive regulation of phosphate metabolic process

ERBB3 ERBB4 BMPR2 IGF1R FGD2 MTOR GPR39

1.71e-04879297GO:0045937
GeneOntologyBiologicalProcesspositive regulation of phosphorus metabolic process

ERBB3 ERBB4 BMPR2 IGF1R FGD2 MTOR GPR39

1.71e-04879297GO:0010562
GeneOntologyBiologicalProcessphosphatidylinositol 3-kinase/protein kinase B signal transduction

ERBB3 ERBB4 IFT80 IGF1R MTOR

1.75e-04382295GO:0043491
GeneOntologyBiologicalProcesspositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

ERBB3 ERBB4 IGF1R MTOR

2.30e-04217294GO:0051897
GeneOntologyBiologicalProcesspositive regulation of cellular respiration

IL10RB GADD45GIP1

3.22e-0419292GO:1901857
GeneOntologyBiologicalProcessregulation of kinase activity

ERBB3 ERBB4 IGF1R FGD2 MTOR GPR39

3.27e-04686296GO:0043549
GeneOntologyBiologicalProcesspositive regulation of developmental growth

ERBB4 BMPR2 IGF1R MTOR

3.27e-04238294GO:0048639
GeneOntologyBiologicalProcessregulation of system process

UNC13B BMPR2 IRAG1 DSP MTOR GPR39

4.69e-04734296GO:0044057
DomainFurin-like

ERBB3 ERBB4 IGF1R

1.05e-077283PF00757
DomainRcpt_L-dom

ERBB3 ERBB4 IGF1R

1.05e-077283IPR000494
DomainFurin-like_Cys-rich_dom

ERBB3 ERBB4 IGF1R

1.05e-077283IPR006211
DomainRecep_L_domain

ERBB3 ERBB4 IGF1R

1.05e-077283PF01030
Domain-

ERBB3 ERBB4 IGF1R

1.05e-0772833.80.20.20
DomainFurin_repeat

ERBB3 ERBB4 IGF1R

2.43e-0618283IPR006212
DomainFU

ERBB3 ERBB4 IGF1R

2.43e-0618283SM00261
DomainTyr_kinase_EGF/ERB/XmrK_rcpt

ERBB3 ERBB4

1.30e-054282IPR016245
DomainGF_recep_IV

ERBB3 ERBB4

3.24e-056282PF14843
DomainGF_recep_IV

ERBB3 ERBB4

3.24e-056282IPR032778
DomainL_dom-like

ERBB3 ERBB4 IGF1R NLRP7 PRAMEF20

1.14e-04328285IPR032675
DomainTyrKc

ERBB3 ERBB4 IGF1R

3.04e-0488283SM00219
DomainTyr_kinase_cat_dom

ERBB3 ERBB4 IGF1R

3.04e-0488283IPR020635
DomainPROTEIN_KINASE_TYR

ERBB3 ERBB4 IGF1R

4.05e-0497283PS00109
DomainTyr_kinase_AS

ERBB3 ERBB4 IGF1R

4.05e-0497283IPR008266
DomainSpectrin_repeat

DSP SYNE2

8.58e-0429282IPR002017
DomainPkinase_Tyr

ERBB3 ERBB4 IGF1R

9.29e-04129283PF07714
DomainSpectrin/alpha-actinin

DSP SYNE2

1.05e-0332282IPR018159
DomainSPEC

DSP SYNE2

1.05e-0332282SM00150
DomainSer-Thr/Tyr_kinase_cat_dom

ERBB3 ERBB4 IGF1R

1.13e-03138283IPR001245
DomainKinase-like_dom

ERBB3 ERBB4 BMPR2 IGF1R MTOR

1.14e-03542285IPR011009
DomainGrowth_fac_rcpt_

ERBB3 ERBB4 IGF1R

1.61e-03156283IPR009030
DomainPROTEIN_KINASE_ATP

ERBB3 ERBB4 BMPR2 IGF1R

4.62e-03459284PS00107
DomainProt_kinase_dom

ERBB3 ERBB4 BMPR2 IGF1R

5.77e-03489284IPR000719
DomainPROTEIN_KINASE_DOM

ERBB3 ERBB4 BMPR2 IGF1R

5.94e-03493284PS50011
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_UBIQUITINATION_OF_RTK_BY_CBL

ERBB3 ERBB4 IGF1R

8.52e-0625233M47934
PathwayWP_SOMATROPH_AXIS_GH_AND_ITS_RELATIONSHIP_TO_DIETARY_RESTRICTION_AND_AGING

IGF1R MTOR

3.80e-056232M39742
PathwayWP_ERBB_SIGNALING_PATHWAY

ERBB3 ERBB4 MTOR

5.50e-0546233MM15950
PathwayKEGG_MEDICUS_REFERENCE_IGF2_IGF1R_PI3K_SIGNALING_PATHWAY

IGF1R MTOR

1.39e-0411232M47484
PathwayREACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING

ERBB3 ERBB4

1.39e-0411232MM15478
PathwayREACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING

ERBB3 ERBB4

1.96e-0413232M27729
PathwayREACTOME_ERBB2_REGULATES_CELL_MOTILITY

ERBB3 ERBB4

1.96e-0413232MM15320
PathwayKEGG_MEDICUS_REFERENCE_IGF_IGF1R_PI3K_SIGNALING_PATHWAY

IGF1R MTOR

1.96e-0413232M47603
PathwayWP_MODULATION_OF_PI3KAKTMTOR_SIGNALING_BY_BIOACTIVE_SPHINGOLIPIDS

IGF1R MTOR

2.29e-0414232M45553
PathwayREACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING

ERBB3 ERBB4

2.29e-0414232MM14761
PathwayREACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING

ERBB3 ERBB4

2.29e-0414232MM14531
PathwayPID_ERBB_NETWORK_PATHWAY

ERBB3 ERBB4

2.64e-0415232M201
PathwayREACTOME_ERBB2_REGULATES_CELL_MOTILITY

ERBB3 ERBB4

2.64e-0415232M27608
PathwayREACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING

ERBB3 ERBB4

3.01e-0416232M570
PathwayKEGG_MEDICUS_REFERENCE_GF_RTK_PI3K_SIGNALING_PATHWAY

ERBB3 ERBB4 IGF1R

3.20e-0483233M47961
PathwayWP_EGFR_TYROSINE_KINASE_INHIBITOR_RESISTANCE

ERBB3 IGF1R MTOR

3.32e-0484233M39839
PathwayKEGG_ERBB_SIGNALING_PATHWAY

ERBB3 ERBB4 MTOR

3.68e-0487233M12467
PathwayKEGG_MEDICUS_REFERENCE_GF_RTK_RAS_PI3K_SIGNALING_PATHWAY

ERBB3 ERBB4 IGF1R

3.93e-0489233M47963
PathwayBIOCARTA_IGF1MTOR_PATHWAY

IGF1R MTOR

4.28e-0419232M16991
PathwayWP_ERBB_SIGNALING

ERBB3 ERBB4 MTOR

4.33e-0492233M39715
PathwayKEGG_MEDICUS_REFERENCE_GF_RTK_RAS_ERK_SIGNALING_PATHWAY

ERBB3 ERBB4 IGF1R

4.33e-0492233M47927
PathwayBIOCARTA_IGF1MTOR_PATHWAY

IGF1R MTOR

4.75e-0420232MM1496
PathwayREACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING

ERBB3 ERBB4

5.77e-0422232M26929
PathwayBIOCARTA_HER2_PATHWAY

ERBB3 ERBB4

6.31e-0423232MM1480
PathwayBIOCARTA_HER2_PATHWAY

ERBB3 ERBB4

6.31e-0423232M18719
PathwayREACTOME_PI3K_AKT_SIGNALING_IN_CANCER

ERBB3 ERBB4 MTOR

7.31e-04110233M27162
PathwayREACTOME_SIGNALING_BY_ERBB2_IN_CANCER

ERBB3 ERBB4

8.08e-0426232M29535
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_SIGNALING

ERBB3 ERBB4

8.08e-0426232MM15501
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_SIGNALING

ERBB3 ERBB4

1.01e-0329232M27756
PathwayWP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING

IGF1R MTOR

1.15e-0331232MM15818
PathwayWP_MAMMARY_GLAND_DEVELOPMENT_PREGNANCY_AND_LACTATION_STAGE_3_OF_4

ERBB3 ERBB4

1.30e-0333232M39455
PathwayREACTOME_SIGNALING_BY_ERBB4

ERBB3 ERBB4

1.30e-0333232MM14523
PathwayWP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING

IGF1R MTOR

1.55e-0336232M39569
PathwayWP_OVARIAN_INFERTILITY

MTOR SYNE2

1.82e-0339232M39458
PathwayWP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA

IGF1R MTOR

1.91e-0340232M48337
PathwayPID_ERBB2_ERBB3_PATHWAY

ERBB3 MTOR

2.31e-0344232M175
PathwayREACTOME_SIGNALING_BY_ERBB2

ERBB3 ERBB4

2.31e-0344232MM14520
PathwayWP_HEART_DEVELOPMENT

ERBB3 BMPR2

2.52e-0346232MM15884
PathwayWP_HEART_DEVELOPMENT

ERBB3 BMPR2

2.63e-0347232M39610
PathwayPID_AJDISS_2PATHWAY

IGF1R DSP

2.74e-0348232M142
PathwayREACTOME_SIGNALING_BY_PTK6

ERBB3 ERBB4

2.74e-0348232MM15479
PathwayREACTOME_SIGNALING_BY_ERBB2

ERBB3 ERBB4

2.97e-0350232M553
PathwayWP_ID_SIGNALING_PATHWAY

BMPR2 IGF1R

2.97e-0350232MM15817
PathwayKEGG_ENDOCYTOSIS

ERBB3 ERBB4 IGF1R

3.05e-03181233M1519
PathwayREACTOME_SIGNALING_BY_PTK6

ERBB3 ERBB4

3.46e-0354232M29742
PathwayKEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY

ERBB3 ERBB4

3.59e-0355232M47952
PathwayREACTOME_SIGNALING_BY_ERBB4

ERBB3 ERBB4

3.98e-0358232M544
Pubmed

mTOR kinase inhibition disrupts neuregulin 1-ERBB3 autocrine signaling and sensitizes NF2-deficient meningioma cellular models to IGF1R inhibition.

ERBB3 IGF1R MTOR

2.32e-09430333273014
Pubmed

Dual targeting of IGF-1R and ErbB3 as a potential therapeutic regimen for ovarian cancer.

ERBB3 IGF1R

7.19e-07230231728045
Pubmed

Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients.

ERBB3 ERBB4

7.19e-07230218182100
Pubmed

HER3, but Not HER4, Plays an Essential Role in the Clinicopathology and Prognosis of Gastric Cancer: A Meta-Analysis.

ERBB3 ERBB4

7.19e-07230227536774
Pubmed

Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling.

ERBB3 ERBB4

7.19e-07230226745281
Pubmed

IGF-1R and ErbB3/HER3 contribute to enhanced proliferation and carcinogenesis in trastuzumab-resistant ovarian cancer model.

ERBB3 IGF1R

7.19e-07230223792093
Pubmed

HER3 and HER4 are highly expressed in human meningiomas.

ERBB3 ERBB4

7.19e-07230231400925
Pubmed

The upgraded role of HER3 and HER4 receptors in breast cancer.

ERBB3 ERBB4

7.19e-07230219481955
Pubmed

Prognostic significance of serum ERBB3 and ERBB4 mRNA in lung adenocarcinoma patients.

ERBB3 ERBB4

7.19e-07230226254096
Pubmed

4-Phenybutyric acid promotes gastric cancer cell migration via histone deacetylase inhibition-mediated HER3/HER4 up-regulation.

ERBB3 ERBB4

7.19e-07230228851073
Pubmed

MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors.

ERBB3 IGF1R

7.19e-07230224282274
Pubmed

[Expression and significance of ErbB3 and ErbB4 in patients with laryngeal squamous cell carcinomas].

ERBB3 ERBB4

7.19e-07230217969526
Pubmed

ErbB family immunohistochemical expression in colorectal cancer patients with higher risk of recurrence after radical surgery.

ERBB3 ERBB4

7.19e-07230219390858
Pubmed

Specific antibodies and sensitive immunoassays for the human epidermal growth factor receptors (HER2, HER3, and HER4).

ERBB3 ERBB4

2.16e-06330228653892
Pubmed

Expression of ErbB3, ErbB4, and neuregulin-1 mRNA during tooth development.

ERBB3 ERBB4

2.16e-06330212112465
Pubmed

ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis.

ERBB3 IGF1R

2.16e-06330232029900
Pubmed

mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR.

IGF1R MTOR

2.16e-06330226584640
Pubmed

ErbB receptor signaling directly controls oligodendrocyte progenitor cell transformation and spontaneous remyelination after spinal cord injury.

ERBB3 ERBB4

2.16e-06330230637799
Pubmed

An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels.

ERBB3 ERBB4

2.16e-06330211867753
Pubmed

Dynamically varying interactions between heregulin and ErbB proteins detected by single-molecule analysis in living cells.

ERBB3 ERBB4

2.16e-06330222891299
Pubmed

Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor.

ERBB3 ERBB4

2.16e-0633027689552
Pubmed

erbB genes in the mouse uterus: cell-specific signaling by epidermal growth factor (EGF) family of growth factors during implantation.

ERBB3 ERBB4

2.16e-0633029851845
Pubmed

Positive prognostic value of HER2-HER3 co-expression and p-mTOR in gastric cancer patients.

ERBB3 MTOR

2.16e-06330229233126
Pubmed

ErbB receptor tyrosine kinase family expression levels in urothelial bladder carcinoma.

ERBB3 ERBB4

2.16e-06330223333248
Pubmed

Expression and potential role of ErbB receptors in type II endometrial cancer.

ERBB3 ERBB4

2.16e-06330223395558
Pubmed

erbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines.

ERBB3 IGF1R

2.16e-06330221939528
Pubmed

Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin.

ERBB3 IGF1R

2.16e-06330220103628
Pubmed

MicroRNA-99a inhibits insulin-induced proliferation, migration, dedifferentiation, and rapamycin resistance of vascular smooth muscle cells by inhibiting insulin-like growth factor-1 receptor and mammalian target of rapamycin.

IGF1R MTOR

2.16e-06330228315335
Pubmed

Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3.

ERBB3 ERBB4

2.16e-0633029516479
Pubmed

The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1.

ERBB3 ERBB4

2.16e-06330228304405
Pubmed

Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis.

ERBB3 ERBB4

2.16e-0633029565587
Pubmed

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells.

IGF1R MTOR

2.16e-06330222729283
Pubmed

TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells.

IGF1R MTOR

2.16e-06330219020730
Pubmed

Evaluation of type 1 growth factor receptor family expression in benign and malignant thyroid lesions.

ERBB3 ERBB4

2.16e-06330218424286
Pubmed

ErbB4, a receptor tyrosine kinase, coordinates organization of the seminiferous tubules in the developing testis.

PLEKHA5 ERBB4

2.16e-06330225058600
Pubmed

Expression and significance of HER family receptors in neuroblastic tumors.

ERBB3 ERBB4

2.16e-06330221203803
Pubmed

Protein expression of HER2, 3, 4 in gastric cancer: correlation with clinical features and survival.

ERBB3 ERBB4

2.16e-06330225731189
Pubmed

High incidence of ErbB3, ErbB4, and MET expression in ovarian cancer.

ERBB3 ERBB4

2.16e-06330224901400
Pubmed

β-Catenin regulates endocardial cushion growth by suppressing p21.

ERBB3 ERBB4 BMPR2

3.72e-063530337385754
Pubmed

The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4: a study in bladder cancer patients.

ERBB3 ERBB4

4.31e-06430216685269
Pubmed

Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay.

ERBB3 ERBB4

4.31e-06430224557338
Pubmed

Analysis of ErbB receptors in pulmonary carcinoid tumors.

ERBB3 ERBB4

4.31e-06430219447869
Pubmed

A TORC2-Akt Feed-Forward Topology Underlies HER3 Resiliency in HER2-Amplified Cancers.

ERBB3 MTOR

4.31e-06430226438156
Pubmed

Inverse regulation of EGFR/HER1 and HER2-4 in normal and malignant human breast tissue.

ERBB3 ERBB4

4.31e-06430223991224
Pubmed

Evaluation of the prognostic and predictive value of HER family mRNA expression in high-risk early breast cancer: a Hellenic Cooperative Oncology Group (HeCOG) study.

ERBB3 ERBB4

4.31e-06430218985033
Pubmed

Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro.

ERBB3 ERBB4

4.31e-06430211425901
Pubmed

[Neuregulin-1 promotes proliferation and migration of human coronary artery smooth muscle cells by enhancing its receptor phosphorylation].

ERBB3 ERBB4

4.31e-06430226648299
Pubmed

Functional genetic approach identifies MET, HER3, IGF1R, INSR pathways as determinants of lapatinib unresponsiveness in HER2-positive gastric cancer.

ERBB3 IGF1R

4.31e-06430224973425
Pubmed

Expression of heregulin, phosphorylated HER-2, HER-3 and HER-4 in HER-2 negative breast cancers.

ERBB3 ERBB4

4.31e-06430219148499
Pubmed

Expression of epidermal growth factors, erbBs, in the nasal mucosa of patients with chronic hypertrophic rhinitis.

ERBB3 ERBB4

4.31e-06430222327010
Pubmed

Additive impact of HER2-/PTK6-RNAi on interactions with HER3 or IGF-1R leads to reduced breast cancer progression in vivo.

ERBB3 IGF1R

4.31e-06430225241146
Pubmed

Activated HER-receptors in predicting outcome of ER-positive breast cancer patients treated with adjuvant endocrine therapy.

ERBB3 ERBB4

4.31e-06430222854050
Pubmed

Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.

ERBB3 ERBB4

4.31e-06430217177598
Pubmed

The erbB/HER type 1 tyrosine kinase receptor family.

ERBB3 ERBB4

4.31e-0643029771475
Pubmed

Expression of the HER-1-4 family of receptor tyrosine kinases in neuroendocrine tumours.

ERBB3 ERBB4

4.31e-06430220204273
Pubmed

HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer.

ERBB3 ERBB4

4.31e-06430221203579
Pubmed

An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in mice.

PLEKHA5 IGF1R

4.31e-06430223518924
Pubmed

Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation.

ERBB3 ERBB4

4.31e-06430215733067
Pubmed

HER Family Protein Expression in a Greek Population with Gastric Cancer. A Retrospective Hellenic Cooperative Oncology Group Study.

ERBB3 ERBB4

4.31e-06430227069134
Pubmed

Co-targeting of IGF1R/mTOR pathway by miR-497 and miR-99a impairs hepatocellular carcinoma development.

IGF1R MTOR

4.31e-06430228624790
Pubmed

A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor.

ERBB3 ERBB4

4.31e-0643028816440
Pubmed

Insulin and IGF1 receptors are essential for the development and steroidogenic function of adult Leydig cells.

PLEKHA5 IGF1R

4.31e-06430229401624
Pubmed

Evaluation of the prognostic significance of HER family mRNA expression in high-risk early breast cancer: a Hellenic Cooperative Oncology Group (HeCOG) validation study.

ERBB3 ERBB4

4.31e-06430226021752
Pubmed

Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases.

ERBB3 ERBB4

4.31e-0643029168115
Pubmed

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.

ERBB3 ERBB4 IGF1R

5.60e-064030330898150
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

PLEKHA5 ERBB4 BMPR2 IGF1R DSP MTOR SYNE2

6.89e-0686130736931259
Pubmed

Heregulin (HRG)-induced mitogenic signaling and cytotoxic activity of a HRG/PE40 ligand toxin in human breast cancer cells.

ERBB3 ERBB4

7.18e-0653029019162
Pubmed

Tissue interaction mediated by neuregulin-1 and ErbB receptors regulates epithelial morphogenesis of mouse embryonic submandibular gland.

ERBB3 ERBB4

7.18e-06530215254894
Pubmed

Leucine-rich repeat and immunoglobulin domain-containing protein-1 (Lrig1) negative regulatory action toward ErbB receptor tyrosine kinases is opposed by leucine-rich repeat and immunoglobulin domain-containing protein 3 (Lrig3).

ERBB3 ERBB4

7.18e-06530223723069
Pubmed

Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity.

ERBB3 ERBB4

7.18e-06530210572067
Pubmed

Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition.

IGF1R MTOR

7.18e-06530227048245
Pubmed

Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.

IGF1R MTOR

7.18e-06530232294406
Pubmed

Hepatitis C Virus Activates a Neuregulin-Driven Circuit to Modify Surface Expression of Growth Factor Receptors of the ErbB Family.

ERBB3 ERBB4

7.18e-06530226886748
Pubmed

Tumor Suppressor PTEN Regulates Negatively Sertoli Cell Proliferation, Testis Size, and Sperm Production In Vivo.

PLEKHA5 IGF1R

7.18e-06530230576429
Pubmed

Expression of epidermal growth factors and a tight junction protein in the nasal mucosa of patients with chronic hypertrophic rhinitis.

ERBB3 ERBB4

7.18e-06530223137868
Pubmed

Isoform-specific expression and function of neuregulin.

ERBB3 ERBB4

7.18e-0653029342050
Pubmed

Localization of phosphorylated ErbB1-4 and heregulin in colorectal cancer.

ERBB3 ERBB4

7.18e-06530225416285
Pubmed

An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells.

ERBB3 ERBB4

7.18e-06530220227043
Pubmed

Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle.

ERBB3 ERBB4

7.18e-0653027589796
Pubmed

Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma.

ERBB3 ERBB4

7.18e-06530222554477
Pubmed

Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions.

ERBB3 ERBB4

7.18e-06530215682390
Pubmed

Neuregulin-1 induces branching morphogenesis in the developing lung through a P13K signal pathway.

ERBB3 ERBB4

7.18e-06530215524405
Pubmed

MicroRNA-193a-3p and -5p suppress the metastasis of human non-small-cell lung cancer by downregulating the ERBB4/PIK3R3/mTOR/S6K2 signaling pathway.

ERBB4 MTOR

7.18e-06530224469061
Pubmed

Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein.

ERBB3 ERBB4

7.18e-06530212939402
Pubmed

Segregation of receptor and ligand regulates activation of epithelial growth factor receptor.

ERBB3 ERBB4

7.18e-06530212646923
Pubmed

Alternative HER/PTEN/Akt pathway activation in HPV positive and negative penile carcinomas.

ERBB3 ERBB4

7.18e-06530221407808
Pubmed

Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development.

ERBB3 ERBB4

7.18e-0653028643489
Pubmed

Ligands for ErbB-family receptors encoded by a neuregulin-like gene.

ERBB3 ERBB4

7.18e-0653029168114
Pubmed

Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids.

ERBB3 ERBB4

1.08e-05630227782124
Pubmed

Neuroglycan C, a novel member of the neuregulin family.

ERBB3 ERBB4

1.08e-05630215358134
Pubmed

LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation.

ERBB3 ERBB4

1.08e-05630215282549
Pubmed

The S100A4 Protein Signals through the ErbB4 Receptor to Promote Neuronal Survival.

ERBB3 ERBB4

1.08e-05630230083275
Pubmed

Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland.

ERBB3 ERBB4

1.08e-05630211278868
Pubmed

Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development.

ERBB3 ERBB4

1.08e-05630215496447
Pubmed

Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways.

ERBB3 ERBB4

1.51e-05730219609946
Pubmed

Multiple essential functions of neuregulin in development.

ERBB3 ERBB4

1.51e-0573027477375
Pubmed

Stretch-induced fetal type II cell differentiation is mediated via ErbB1-ErbB4 interactions.

ERBB3 ERBB4

1.51e-05730222493501
Pubmed

Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely to play a role in Lrig3-dependent inner ear morphogenesis.

ERBB3 ERBB4

1.51e-05730220126551
Pubmed

Neuregulin-1/ErbB4 signaling controls the migration of oligodendrocyte precursor cells during development.

ERBB3 ERBB4

1.51e-05730222504067
Pubmed

A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions.

ERBB3 MTOR

1.51e-05730217148612
InteractionDUSP18 interactions

ERBB3 ERBB4 IGF1R

5.31e-0624293int:DUSP18
InteractionSOCS2 interactions

ERBB3 ERBB4 IGF1R MTOR

1.18e-0599294int:SOCS2
InteractionSH2B1 interactions

ERBB3 ERBB4 IGF1R

1.29e-0532293int:SH2B1
InteractionTVP23B interactions

ERBB3 ERBB4 TLCD4

1.29e-0532293int:TVP23B
InteractionMATK interactions

ERBB3 ERBB4 IGF1R

3.18e-0543293int:MATK
InteractionNRG2 interactions

ERBB3 ERBB4

4.18e-057292int:NRG2
InteractionVAV3 interactions

ERBB3 ERBB4 IGF1R

6.68e-0555293int:VAV3
InteractionMUC4 interactions

ERBB3 ERBB4

7.15e-059292int:MUC4
InteractionFES interactions

ERBB3 ERBB4 DSP

9.12e-0561293int:FES
InteractionLRIG1 interactions

ERBB3 ERBB4 NLRP7

1.00e-0463293int:LRIG1
InteractionPTPN7 interactions

ERBB3 ERBB4 IGF1R

1.10e-0465293int:PTPN7
InteractionGRB7 interactions

ERBB3 ERBB4 RARS1 MTOR

1.18e-04178294int:GRB7
InteractionMTMR9 interactions

ERBB3 ERBB4 DSP

1.43e-0471293int:MTMR9
InteractionPPM1F interactions

ERBB3 ERBB4 IGF1R

1.43e-0471293int:PPM1F
InteractionMTMR2 interactions

ERBB3 ERBB4 GADD45GIP1

1.49e-0472293int:MTMR2
InteractionEEF2 interactions

UQCRC1 IGF1R RARS1 NLRP7 EMC4 DSP

1.61e-04588296int:EEF2
InteractionPTPN20 interactions

ERBB3 ERBB4

1.80e-0414292int:PTPN20
InteractionSMIM20 interactions

ERBB3 ERBB4

1.80e-0414292int:SMIM20
InteractionSTYX interactions

ERBB3 ERBB4 IGF1R

2.36e-0484293int:STYX
InteractionDUSP21 interactions

ERBB3 ERBB4 IGF1R

2.44e-0485293int:DUSP21
InteractionATP5F1A interactions

ERBB3 UQCRC1 IGF1R RARS1 NLRP7 MTOR

2.55e-04640296int:ATP5F1A
InteractionTMEM134 interactions

ERBB3 ERBB4

2.68e-0417292int:TMEM134
InteractionSHD interactions

ERBB3 ERBB4

3.02e-0418292int:SHD
InteractionPDZD8 interactions

ERBB3 IGF1R RARS1 EMC4 SYNE2

3.29e-04428295int:PDZD8
InteractionHSP90AB1 interactions

UNC13B ERBB3 PTDSS2 IGF1R EMC4 DSP MTOR

3.38e-04960297int:HSP90AB1
InteractionDUSP19 interactions

ERBB3 ERBB4 IGF1R

3.50e-0496293int:DUSP19
InteractionNCK1 interactions

ERBB3 ERBB4 IGF1R DSP

3.92e-04244294int:NCK1
InteractionSHC4 interactions

ERBB3 ERBB4

4.54e-0422292int:SHC4
InteractionLCK interactions

PLEKHA5 ERBB3 ERBB4 RARS1 DSP

4.72e-04463295int:LCK
InteractionCAPN6 interactions

SYNE2 MICU1

4.96e-0423292int:CAPN6
InteractionLAMTOR2 interactions

ERBB3 UQCRC1 MTOR

5.08e-04109293int:LAMTOR2
InteractionCDH5 interactions

BMPR2 DSP MICU1

5.08e-04109293int:CDH5
InteractionPTPRR interactions

ERBB3 ERBB4 IGF1R

5.21e-04110293int:PTPRR
InteractionSOCS3 interactions

ERBB3 ERBB4 IGF1R

5.21e-04110293int:SOCS3
InteractionILKAP interactions

ERBB3 ERBB4 IGF1R

5.21e-04110293int:ILKAP
InteractionSLA2 interactions

ERBB3 ERBB4

5.41e-0424292int:SLA2
InteractionSOCS5 interactions

ERBB3 ERBB4

5.41e-0424292int:SOCS5
InteractionFKBP1A interactions

ERBB3 ERBB4 MTOR

5.64e-04113293int:FKBP1A
InteractionSH2B3 interactions

ERBB3 ERBB4

5.88e-0425292int:SH2B3
InteractionHSH2D interactions

ERBB3 ERBB4

5.88e-0425292int:HSH2D
InteractionPTPN6 interactions

ERBB3 ERBB4 IGF1R GADD45GIP1

6.41e-04278294int:PTPN6
InteractionZNF532 interactions

ERBB3 ERBB4

6.86e-0427292int:ZNF532
InteractionSTAP1 interactions

ERBB3 ERBB4

6.86e-0427292int:STAP1
Cytoband11q13

MYEOV FOLR3

2.90e-0311831211q13
GeneFamilyErb-b2 receptor tyrosine kinases

ERBB3 ERBB4

8.47e-0642221096
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PLEKHA5 FGD2

2.57e-02206222682
CoexpressionFINETTI_BREAST_CANCERS_KINOME_BLUE

ERBB3 ERBB4 IGF1R

1.77e-0621303M2862
CoexpressionCUI_DEVELOPING_HEART_TRABECULAR_ATRIAL_CARDIOMYOCYTE

PLEKHA5 BMPR2 DSP TLCD4

5.02e-05179304M39308
CoexpressionGSE7460_WT_VS_FOXP3_HET_ACT_TCONV_UP

ERBB3 IFT80 IRAG1 SYNE2

7.57e-05199304M5709
CoexpressionGSE41867_MEMORY_VS_EXHAUSTED_CD8_TCELL_DAY30_LCMV_DN

IL10RB IFT80 IGF1R MTOR

7.72e-05200304M9482
CoexpressionAtlasdev gonad_e13.5_M_SertoliCell_Sox9_k-means-cluster#4_top-relative-expression-ranked_100

UNC13B ERBB3 DSP

1.03e-0615293gudmap_dev gonad_e13.5_M_SertoliCell_Sox9_k4_100
CoexpressionAtlasdev gonad_e13.5_M_SertoliCell_Sox9_top-relative-expression-ranked_100

UNC13B ERBB3 ERBB4 DSP

4.56e-0682294gudmap_dev gonad_e13.5_M_SertoliCell_Sox9_100
CoexpressionAtlasdev gonad_e13.5_M_SertoliCell_Sox9_top-relative-expression-ranked_200

UNC13B ERBB3 ERBB4 DSP

8.06e-05170294gudmap_dev gonad_e13.5_M_SertoliCell_Sox9_200
CoexpressionAtlasdev gonad_e12.5_M_SertoliCell_Sox9_k-means-cluster#4_top-relative-expression-ranked_200

ERBB3 DSP

1.39e-0413292gudmap_dev gonad_e12.5_M_SertoliCell_Sox9_k4_200
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B ERBB3 ERBB4 GPR39 SYNE2

1.14e-07170315a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

UNC13B ERBB3 ERBB4 DSP GPR39

1.73e-07185315cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellPCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB3 ERBB4 DSP GPR39

1.88e-071883150d86044bc340e3efb90d0022dd299873639d831c
ToppCellPCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB3 ERBB4 DSP GPR39

1.88e-07188315beb2df2332a46cc81b10e8e29fc9829020111f03
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB3 ERBB4 DSP GPR39

1.93e-071893157659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCellPCW_13-14-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB3 ERBB4 DSP GPR39

2.03e-0719131563aa671837b79d2feb7ed1e67712cc01caf72bef
ToppCellwk_15-18-Epithelial-Airway_epithelial_progenitor-epi-airway_progenitor_early|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

UNC13B PLEKHA5 ERBB3 DSP GPR39

2.14e-07193315de569c6e507856fd3ac2311f246cb597074ed30c
ToppCellPCW_07-8.5-Epithelial|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB3 ERBB4 DSP GPR39

2.20e-07194315f63ceedb88a9abc8644ee94adfd541e7817c1e3a
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB3 ERBB4 DSP GPR39

2.20e-07194315f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
ToppCellPCW_13-14-Epithelial-Epithelial_proliferating|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB3 ERBB4 DSP GPR39

2.31e-071963157b17d47b7758d8ccf9dbefd097aeb553791a1eed
ToppCellPCW_10-12-Epithelial|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB3 ERBB4 DSP GPR39

2.31e-071963159bfb31ff3e4f2c0a9405c418c86bfec5dbca23e2
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ERBB4 IGF1R DSP GPR39 SYNE2

2.43e-071983151408e02e053ad3406229bfe8189da03be6366e81
ToppCellPCW_13-14-Epithelial|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB3 ERBB4 DSP GPR39

2.43e-0719831548eb6f69a464a34ab32e8d425a22b9d45ec20428
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B ERBB3 ERBB4 GPR39

5.20e-06166314c20479fe7a4306320d7f26e78bf956225f00f35a
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B PLEKHA5 ERBB4 GPR39

6.13e-06173314b799c06a6a5754668e789f70c0c8bc1508568575
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B ERBB3 ERBB4 GPR39

7.01e-06179314cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCellCOVID-19-Epithelial_cells-ECM-high_epithelial|COVID-19 / group, cell type (main and fine annotations)

UNC13B ERBB4 DSP GPR39

7.65e-06183314dc1d380bf7564f290256cb7108063d1bd2da732b
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB4 DSP GPR39

7.65e-06183314c5b10571599dc26476170b54b53f09c23e6b3117
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

UNC13B ERBB3 ERBB4 GPR39

8.15e-061863142ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB3 DSP GPR39

8.15e-06186314bb0bfe9a015151be08a6ffc5d82896d0556d76de
ToppCellEpithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|World / Lineage, Cell type, age group and donor

UNC13B ERBB3 ERBB4 GPR39

8.33e-0618731481cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCellPCW_10-12-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB3 ERBB4 GPR39

8.51e-061883143cfba3addcc9058f4ec31ad96261f79988f551a0
ToppCellCOVID-19-Epithelial_cells|COVID-19 / group, cell type (main and fine annotations)

UNC13B ERBB3 ERBB4 GPR39

8.51e-06188314c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_intermediate_(1)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB4 DSP GPR39

8.87e-06190314c95032bb3ee2b3d40fdf48016acb46d6f78a48a6
ToppCellEpithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|World / Lineage, Cell type, age group and donor

UNC13B ERBB3 ERBB4 GPR39

9.05e-06191314d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB3 DSP GPR39

9.24e-061923141aa5e4d9b32013a3f272561dcb8377f6805706df
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHA5 ERBB4 IGF1R SYNE2

9.24e-06192314e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellPCW_10-12-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ERBB3 ERBB4 DSP GPR39

9.43e-06193314b25cdca3a1e381784ae48ca73c51cbb6ac62b811
ToppCellPCW_13-14-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ERBB3 ERBB4 DSP GPR39

9.43e-06193314b38aaffbea36ef6c08ebe82675438f873c89b242
ToppCellFetal_29-31_weeks-Epithelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

UNC13B ERBB3 ERBB4 GPR39

9.43e-06193314a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCellPCW_13-14-Epithelial-Epithelial_airway|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ERBB3 ERBB4 DSP GPR39

9.63e-061943147b2b40a56eb9c7203ca50133b2da4fd8fdd4a5cf
ToppCellPCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB4 DSP GPR39

9.63e-06194314c197e4acbff42a9f0410b6801c2bfcf6160aefc1
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHA5 ERBB4 IGF1R SYNE2

9.63e-061943147002937e8903e037332a215d00fbc7c7843b33f2
ToppCellPCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB3 ERBB4 DSP

9.63e-06194314c011cd59bb4ca4134331cba0f5d73bdbd7011d64
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

PLEKHA5 ERBB4 DNAH6 SYNE2

9.82e-06195314fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellPCW_10-12-Epithelial-Epithelial_airway-epi_intermediate_(1)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ERBB3 ERBB4 DSP GPR39

9.82e-06195314d67a2b489c29bfd575751c13d2a5b1efdec5240a
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

PLEKHA5 ERBB4 DNAH6 SYNE2

9.82e-06195314eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

UNC13B ERBB4 IGF1R GPR39

1.04e-051983141996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ERBB4 IGF1R DSP GPR39

1.04e-05198314af399569c718f5fd971d73a7926768c9311002a3
ToppCellPCW_10-12-Epithelial-Epithelial_airway|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ERBB3 ERBB4 DSP GPR39

1.04e-051983149a12e5e47236433e512c668005fe3f8be6fde95c
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ERBB3 IGF1R DSP SYNE2

1.09e-0520031497f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCellNS-control-d_0-4-Epithelial|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PLEKHA5 ERBB3 IGF1R DSP

1.09e-05200314d014959891893b6d3854a471fba1dc50c6625a0a
ToppCellNS-control|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ERBB3 IGF1R DSP SYNE2

1.09e-05200314ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ERBB3 ERBB4 TLCD4

1.47e-041483139fe3c0a5904b8e9a0f28130f8d84d4f2a819b06c
ToppCell5'-Adult-Appendix-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ERBB3 MYEOV DSP

1.68e-041553135fabe24a784f0be46040ffc886eabd8d5ce78121
ToppCellAT1-AT2_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

ERBB3 MYEOV DSP

1.78e-041583133bc51cfd37b289cc3e866b54ce55a298e5eff690
ToppCell356C-Fibroblasts-Fibroblast-D-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FGD2 DSP FOLR3

1.81e-04159313299e2162a82e31196d7f3a110c2db622349edfff
ToppCell356C-Fibroblasts-Fibroblast-D|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

FGD2 DSP FOLR3

1.81e-041593130a3a363b30a8c741e1a3e2525725108d03c21776
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

UNC13B ERBB4 GPR39

1.81e-04159313e6ff9d2bce62bf9ea173af80b688eeb40fa4ea4c
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ERBB4 IGF1R GPR39

1.81e-041593138680b054622f573a82b1625fb93c2d5db81d1034
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ERBB4 DNAH6 GPR39

2.02e-0416531382530f96aaefe28a13bad0474bbad043f127a86c
ToppCellPCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ERBB4 DNAH6 GPR39

2.02e-041653130c714e852f912b5749de4cb0895406673979b2e6
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ERBB4 IRAG1 AJM1

2.05e-041663139a341dc7b756252caeaac1e934384911c880a634
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ERBB4 IRAG1 AJM1

2.05e-04166313390cf5e56b72fcaf3b8520930bd35a3e3e173711
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

NLRP7 AJM1 SYNE2

2.09e-04167313abc4ba308ca3be41b0da604f5d82579fd58dff7b
ToppCelldroplet-Lung-nan-18m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLEKHA5 IRAG1 FGD2

2.17e-04169313149a4f83da15bdeb170e980fb5b5b1af89ae07a6
ToppCelldroplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PLEKHA5 IRAG1 FGD2

2.20e-04170313bf589c4297ccc90e5f51e3d0fcc229548af4fcef
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-epithelial_progenitor_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ERBB3 DSP NT5C1B

2.24e-041713133ef44a5e3e8f81424f1e9aa302860b6688a549b8
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMPR2 IRAG1 FGD2

2.28e-041723137fb31ccbcd0204c3612986a6bc20d57ed6825e9c
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMPR2 IRAG1 FGD2

2.28e-041723132a4614b3d25e8c6b095e6992d8ca35371dcdb5e1
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB3 DSP SYNE2

2.32e-04173313e1378201b15ffb98e196ac39fe3ee4b4078953bd
ToppCellfacs-Large_Intestine-Proximal-3m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB3 DSP SYNE2

2.32e-0417331399532bb768ee35fed939a377acb5215d3f8904bd
ToppCellwk_15-18-Epithelial-Distal_epithelial-type_I_pneumocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB3 DSP

2.36e-041743132cd6638b361ca05ab83d09ce657194aed97873b7
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RARS1 FGD2 PNMA8A

2.44e-0417631376fdf211bce101e83a27d822cb399487bd107027
ToppCellClub_cells-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

ERBB3 DSP SYNE2

2.44e-0417631388c4ed0ab4a4ede8cad21385d799b723b5786cd9
ToppCellControl-Epithelial_alveolar-AT_1-Differentiating_AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IFT80 DSP GPR39

2.48e-041773139af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

UNC13B ERBB4 GPR39

2.56e-04179313815b959ce8721c5ded70c0ca6e318dafc691746e
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

UNC13B PTDSS2 PNMA8A

2.61e-04180313c72f15763ba707189e29c85db533557f01c7fdb1
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B GPR39 AJM1

2.65e-041813137af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCellfacs-Heart-LA-18m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UQCRC1 GPR39 GADD45GIP1

2.69e-0418231347b747722766dbcc6a73673e99ee5f938b82b890
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

UNC13B ERBB4 GPR39

2.78e-04184313369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B ERBB4 GPR39

2.82e-0418531398b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCellAdult-Epithelial-club_cell-D231|Adult / Lineage, Cell type, age group and donor

ERBB4 IGF1R DSP

2.92e-04187313ee59d7d3de5879738ff0b9c3ea5e4847fb48cb86
ToppCellCOVID-19-Epithelial_cells-Airway_basal|COVID-19 / group, cell type (main and fine annotations)

ERBB4 DSP GPR39

2.92e-041873138407a82e98f56a94ea26562bcb6bbe00a8f41661
ToppCellControl-Epithelial_cells|Control / group, cell type (main and fine annotations)

UNC13B ERBB4 GPR39

2.96e-04188313707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCellCOVID-19-lung-Secretory|lung / Disease (COVID-19 only), tissue and cell type

ERBB3 ERBB4 DSP

3.01e-0418931384d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB3 DSP

3.01e-041893135d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCellwk_15-18-Epithelial-Airway_epithelial_progenitor-epi-stalk_early|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB3 DSP

3.01e-04189313a6c62b456982067ad4d224a2efa3919969000693
ToppCellIPF-Epithelial-Club|IPF / Disease state, Lineage and Cell class

ERBB3 ERBB4 GPR39

3.01e-04189313f3fcef008ef252b29ac6d567fef27f9acf9cd70f
ToppCellPBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IGF1R FOLR3 TLCD4

3.01e-041893133b35022c0619df6db234613aa53a076899ca9562
ToppCellPBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGF1R FOLR3 TLCD4

3.01e-04189313358ff514f1c8aa46067208ddf1b68396d789c130
ToppCellPCW_05-06-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ERBB4 DSP GPR39

3.01e-04189313c8b8f860aaf6c73863cd79941db6b469c830ef06
ToppCellAdult-Epithelial-club_cell|Adult / Lineage, Cell type, age group and donor

ERBB4 IGF1R DSP

3.05e-04190313756bff697d30aec56c0ebfca94295f084a15bf37
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-filiform|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLEKHA5 FGD2 SYNE2

3.05e-041903138a53f4d3c9aca45b5826f53f7dcdfb8bc8280acb
ToppCellCOVID-19-lung-AT2|COVID-19 / Disease (COVID-19 only), tissue and cell type

UNC13B ERBB4 GPR39

3.05e-0419031327a1a86620fe9b5ee930d388b32352206485e6d0
ToppCellBL-critical-LOC-Epithelial-Squamous|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ERBB3 MYEOV DSP

3.10e-041913133f9b8c4fb72ae6f3167b187e6715c4dcb3159f98
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

UNC13B ERBB4 GPR39

3.10e-04191313ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ERBB3 ERBB4 GPR39

3.10e-0419131360ff989fe99d243a3d52955223680cdd1f1917a4
ToppCellPCW_05-06-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB4 GPR39

3.10e-0419131305731ece7867659c662f952812805f947032fe10
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B ERBB4 GPR39

3.10e-04191313e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCellPCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB4 GPR39

3.10e-0419131339220f4a345e328f7fa4fd462a0abeea821b3e02
ToppCellIPF-Epithelial-Club|World / Disease state, Lineage and Cell class

ERBB3 ERBB4 GPR39

3.10e-041913133c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCellCOVID-19-lung-AT2|lung / Disease (COVID-19 only), tissue and cell type

UNC13B ERBB4 GPR39

3.10e-04191313276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB3 GPR39

3.15e-04192313d3634574b2e8d2ded6446969361b70761b331aea
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

UNC13B DSP GPR39

3.15e-0419231325378b5e4b0cea8415ff125783511fc25a56fc00
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

UNC13B ERBB3 DSP

3.15e-04192313b7c01e12b3e9be960a741b08835f1dfff65d0d47
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

UNC13B ERBB4 GPR39

3.15e-04192313efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B IL10RB IGF1R

3.15e-041923139ae05db5bfb8b9d3935c0328e6f2d489d2b1ebfd
ToppCellEpithelial|World / Lineage, Cell type, age group and donor

UNC13B ERBB4 GPR39

3.15e-04192313499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

PLEKHA5 ERBB3 DSP

3.15e-04192313916fbec1c7ab7969bda711886ac88e877e30c280
DrugPKI166

ERBB3 ERBB4 DSP MTOR

4.58e-0748304CID006918403
DrugPD168393

ERBB3 ERBB4

1.01e-054302CID000004708
Drug4-HT

ERBB3 ERBB4 IFT80 IGF1R

1.07e-05105304CID005284643
DrugNVP ADW742

IGF1R MTOR

1.67e-055302ctd:C502355
Drug6-quinolinecarbaldehyde

ERBB3 ERBB4

1.67e-055302CID000765653
DrugRG 14921

ERBB3 ERBB4

1.67e-055302CID000197517
DrugEGFR inhibitor

ERBB3 ERBB4 IGF1R MTOR

1.81e-05120304CID009549299
DrugSnCe6

ERBB3 ERBB4

2.51e-056302CID000164259
DrugCochliobolic acid

ERBB3 ERBB4

2.51e-056302CID006450172
Drugdiethyl ester

ERBB3 ERBB4

2.51e-056302CID000264327
DrugSSFSB

ERBB3 ERBB4

3.51e-057302CID003035734
Drugpp175

IGF1R MTOR

3.51e-057302CID000006543
DrugRG 14467

ERBB3 ERBB4

3.51e-057302CID000132069
DrugPesticides

ERBB3 PTDSS2 IGF1R GPR39

4.34e-05150304ctd:D010575
DrugFolfox protocol

ERBB3 IGF1R

4.68e-058302ctd:C410216
DrugTAPI-1

ERBB3 ERBB4 IGF1R

5.76e-0557303CID009827273
Drug2'-fluoro-6,7-methylenedioxy-2-phenyl-4-quinolone

IGF1R MTOR

6.01e-059302ctd:C525063
DrugH 661

ERBB3 ERBB4

7.50e-0510302CID003056529
Drug6-(methylamino)pyrido(3,4-d)pyrimidine

ERBB3 ERBB4

7.50e-0510302ctd:C107875
Drug4,5-dianilinophthalimide

ERBB3 ERBB4

9.16e-0511302CID000001697
DrugBE-23372M

ERBB3 ERBB4

9.16e-0511302CID005311105
DrugDivonex

IL10RB ERBB3 ERBB4

1.02e-0469303CID000002522
DrugCGP 8065

RARS1 NT5C1B

1.10e-0412302CID005492311
DrugMefenamic acid [61-68-7]; Up 200; 16.6uM; PC3; HT_HG-U133A

MFSD9 RARS1 DSP SYNE2

1.22e-041963041821_UP
Drug2nq6

ERBB3 ERBB4

1.30e-0413302CID011809364
DrugAndrogen Antagonists

ERBB3 ERBB4 IGF1R

1.31e-0475303ctd:D000726
DrugDD-PCR

ERBB3 ERBB4 IGF1R

1.31e-0475303CID003081759
DrugPkcs

UNC13B ERBB3 ERBB4 MTOR

1.63e-04211304CID000164073
Drug2aq7

ERBB3 ERBB4

1.74e-0415302CID005494446
Drug2-py

ERBB4 SYNE2

1.74e-0415302CID010126464
Druglapatinib

ERBB3 ERBB4 MTOR

1.96e-0486303CID000208908
Drug4-anilinoquinazoline

ERBB3 ERBB4

1.99e-0416302CID000324081
DrugPPTP

IGF1R MTOR

1.99e-0416302CID000146272
Drugpropanedinitrile

ERBB3 ERBB4

1.99e-0416302CID000008010
Drug2 pc

ERBB3 ERBB4

2.53e-0418302CID000440046
Drugvandetanib

ERBB3 ERBB4 MTOR

2.97e-0499303CID003081361
DrugNCI60_002052

ERBB3 IGF1R

3.14e-0420302CID006801032
DrugPX-866

ERBB3 MTOR

3.14e-0420302CID009849735
Druggefitinib

ERBB3 ERBB4 IGF1R MTOR

3.35e-04255304CID000123631
DrugCCRIS 4306

IGF1R MTOR

3.47e-0421302CID011984829
DrugN1-aminopropylagmatine

ERBB3 ERBB4

3.81e-0422302CID000541551
DrugPHA665752

ERBB3 MTOR

4.17e-0423302CID010461815
Drugdeoxythymidin

ERBB4 IGF1R NT5C1B MTOR

4.52e-04276304CID000001134
Drugtyrphostin RG13022

ERBB3 ERBB4

4.94e-0425302CID000005060
DiseaseMalignant neoplasm of skin

ERBB3 ERBB4 IGF1R

2.40e-0559283C0007114
DiseaseSkin Neoplasms

ERBB3 ERBB4 IGF1R

2.40e-0559283C0037286
Diseasegallbladder neoplasm

ERBB3 ERBB4

4.75e-0511282C0016978
DiseaseMalignant neoplasm of gallbladder

ERBB3 ERBB4

4.75e-0511282C0153452
DiseaseMalignant neoplasm of breast

MFSD9 ERBB3 ERBB4 BMPR2 IGF1R MTOR SYNE2

5.02e-051074287C0006142
DiseaseRespiratory Depression

IFT80 IGF1R

6.73e-0513282C0235063
DiseaseRespiratory Insufficiency

IFT80 IGF1R

6.73e-0513282C0035229
DiseaseRespiratory Failure

IFT80 IGF1R

6.73e-0513282C1145670
Diseasemedian neuropathy (biomarker_via_orthology)

ERBB3 ERBB4

7.85e-0514282DOID:571 (biomarker_via_orthology)
DiseaseNeoplasm of uncertain or unknown behavior of bladder

ERBB3 MTOR

9.05e-0515282C0496930
DiseaseBenign neoplasm of bladder

ERBB3 MTOR

9.05e-0515282C0154017
DiseaseCarcinoma in situ of bladder

ERBB3 MTOR

9.05e-0515282C0154091
Diseasehypertrophic cardiomyopathy (is_marker_for)

IGF1R DSP

1.17e-0417282DOID:11984 (is_marker_for)
DiseaseCarcinoma of bladder

ERBB3 MTOR

1.32e-0418282C0699885
DiseaseBreast Carcinoma

ERBB3 ERBB4 BMPR2 IGF1R MTOR

1.37e-04538285C0678222
Diseaselaryngeal squamous cell carcinoma (is_marker_for)

ERBB3 ERBB4

1.47e-0419282DOID:2876 (is_marker_for)
Diseasestomach carcinoma (is_marker_for)

ERBB3 ERBB4

2.37e-0424282DOID:5517 (is_marker_for)
DiseaseOvarian Mucinous Adenocarcinoma

ERBB3 MTOR

3.97e-0431282C1335167
Diseaseintestinal cancer (implicated_via_orthology)

ERBB3 ERBB4

4.23e-0432282DOID:10155 (implicated_via_orthology)
DiseaseSquamous cell carcinoma of lung

ERBB4 IGF1R

4.23e-0432282C0149782
DiseaseParoxysmal atrial fibrillation

ERBB4 IGF1R SYNE2

4.31e-04156283C0235480
Diseasefamilial atrial fibrillation

ERBB4 IGF1R SYNE2

4.31e-04156283C3468561
Diseaseprostate cancer (is_marker_for)

ERBB3 ERBB4 IGF1R

4.31e-04156283DOID:10283 (is_marker_for)
DiseasePersistent atrial fibrillation

ERBB4 IGF1R SYNE2

4.31e-04156283C2585653
DiseaseAtrial Fibrillation

ERBB4 IGF1R SYNE2

4.64e-04160283C0004238
Diseasetongue squamous cell carcinoma (is_marker_for)

ERBB3 ERBB4

5.67e-0437282DOID:0050865 (is_marker_for)
Diseaseductal carcinoma in situ (is_marker_for)

ERBB3 ERBB4

6.30e-0439282DOID:0060074 (is_marker_for)
Diseasealcohol use disorder (implicated_via_orthology)

UNC13B ERBB3 ERBB4

8.24e-04195283DOID:1574 (implicated_via_orthology)
Diseaseattention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement

PLEKHA5 ERBB3 ERBB4 BMPR2 IGF1R

8.52e-04801285EFO_0003888, EFO_0007052, MONDO_0002491

Protein segments in the cluster

PeptideGeneStartEntry
MCLLWEQGQQITMMR

NT5C1B

86

Q96P26
YMVMVKCWMIDENIR

ERBB3

941

P21860
MVMVKCWMIDADSRP

ERBB4

951

Q15303
MCMIMAASEPRALDW

AJM1

951

C9J069
MSKTMAMNLLEDWCR

PNMA8A

1

Q86V59
LSVAFMCWNMMQVLM

GPR39

236

O43194
WDIFLVRLLMAMAVM

MFSD9

286

Q8NBP5
NCPDMLFELMRMCWQ

IGF1R

1236

P08069
CQHWQVIWMMAAVML

IRAG1

841

Q9Y6F6
MGFTRLMQAMWKCAQ

MICU1

451

Q9BPX6
IINQGVCLRMMAMSW

OR14L1P

136

Q8NHC6
SMEIMWARMDVALRS

MYEOV

191

Q96EZ4
MDMAWQMMQLLLLAL

FOLR3

1

P41439
DDMMFVLQGQWMRLC

UQCRC1

366

P31930
WLNCKVDMFGIMMLL

PTTG1IP2

91

P0DTF9
MCMWVRAMDLYSRVV

DNAH6

2881

Q9C0G6
MWACLAAMAVANRDM

IFT80

616

Q9P2H3
CLGWMRQQRAEMDMV

DSP

191

P15924
CAEERMAELMMIWER

BMPR2

496

Q13873
WMVAVILMASVFMVC

IL10RB

221

Q08334
RAPQWVRDKMVTMCM

FGD2

451

Q7Z6J4
IAECMAKMPQMIVNW

GADD45GIP1

121

Q8TAE8
MVCMMAWRPIQALMA

EMC4

101

Q5J8M3
MDEIVTLMREFWVMN

MTOR

1031

P42345
NMWRMLLCEAVAAVM

RARS1

631

P54136
CAMSMERRMKIEETW

SYNE2

6121

Q8WXH0
IRDWWMCMIISVMFE

PTDSS2

211

Q9BVG9
WSEAMARRCLPNAMM

PRAMEF20

116

Q5VT98
HIEWERTMMLMLCDL

NLRP7

741

Q8WX94
ISCVVLDVMNVMWMI

TLCD4

221

Q96MV1
LWRVVMNTMERMIVL

UNC13B

1296

O14795
MELWMKAMLDAALVQ

PLEKHA5

256

Q9HAU0