Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

SETD1B KMT2B KMT2A NSD3

6.07e-0720694GO:0042800
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

SETD1B KMT2B KMT2A

2.18e-068693GO:0140945
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

SETD1B KMT2B KMT2A

4.66e-0610693GO:0140999
GeneOntologyMolecularFunctionRNA polymerase II C-terminal domain binding

SCAF8 BRD4 SCAF4

6.39e-0611693GO:0099122
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

SETD1B KMT2B KMT2A NSD3

1.60e-0544694GO:0140938
GeneOntologyMolecularFunctionsynaptic receptor adaptor activity

SHANK1 SHANK2

7.03e-054692GO:0030160
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

SETD1B KMT2B KMT2A NSD3

9.00e-0568694GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

SETD1B KMT2B KMT2A NSD3

9.53e-0569694GO:0016278
GeneOntologyMolecularFunctionhistone methyltransferase activity

SETD1B KMT2B KMT2A NSD3

1.07e-0471694GO:0042054
GeneOntologyMolecularFunctionRNA polymerase II C-terminal domain phosphoserine binding

SCAF8 SCAF4

1.17e-045692GO:1990269
GeneOntologyMolecularFunctionlysine-acetylated histone binding

BRD4 KMT2A BRD3

1.50e-0430693GO:0070577
GeneOntologyMolecularFunctionacetylation-dependent protein binding

BRD4 KMT2A BRD3

1.66e-0431693GO:0140033
GeneOntologyMolecularFunctionactin binding

EPS8 SHROOM3 WAS WASHC1 FMN2 RDX FHOD3 WASF1

2.40e-04479698GO:0003779
GeneOntologyMolecularFunctionRNA polymerase II complex binding

SCAF8 BRD4 SCAF4

3.30e-0439693GO:0000993
GeneOntologyMolecularFunctionprotein methyltransferase activity

SETD1B KMT2B KMT2A NSD3

4.46e-04103694GO:0008276
GeneOntologyMolecularFunctionN-methyltransferase activity

SETD1B KMT2B KMT2A NSD3

4.80e-04105694GO:0008170
GeneOntologyMolecularFunctionRNA polymerase core enzyme binding

SCAF8 BRD4 SCAF4

5.05e-0445693GO:0043175
GeneOntologyMolecularFunctionRNA polymerase II CTD heptapeptide repeat kinase activity

CDK12 BRD4

5.20e-0410692GO:0008353
GeneOntologyMolecularFunctionunmethylated CpG binding

KMT2B KMT2A

5.20e-0410692GO:0045322
GeneOntologyMolecularFunctionstructural constituent of postsynaptic density

SHANK1 SHANK2

6.34e-0411692GO:0098919
GeneOntologyMolecularFunctionphosphoserine residue binding

SCAF8 SCAF4

7.60e-0412692GO:0050815
GeneOntologyMolecularFunctionionotropic glutamate receptor binding

SHANK1 SHANK2 GNAS

7.73e-0452693GO:0035255
GeneOntologyMolecularFunctionstructural constituent of postsynaptic specialization

SHANK1 SHANK2

8.96e-0413692GO:0098879
GeneOntologyMolecularFunctionzinc ion binding

KMT2B ZFHX4 ZFHX2 KMT2A ZFHX3 ZNF385C MARCHF4 THAP1 RXRB IKZF4

9.27e-048916910GO:0008270
GeneOntologyMolecularFunctionprotein kinase A binding

RDX WASF1 PRRC1

1.06e-0358693GO:0051018
GeneOntologyMolecularFunctionRNA polymerase binding

SCAF8 BRD4 SCAF4

1.48e-0365693GO:0070063
GeneOntologyMolecularFunctionSH3 domain binding

SHANK1 SHANK2 WAS SH3BP1

1.52e-03143694GO:0017124
GeneOntologyMolecularFunctionbasal RNA polymerase II transcription machinery binding

SCAF8 BRD4 SCAF4

1.55e-0366693GO:0001099
GeneOntologyMolecularFunctionbasal transcription machinery binding

SCAF8 BRD4 SCAF4

1.55e-0366693GO:0001098
GeneOntologyMolecularFunctionglutamate receptor binding

SHANK1 SHANK2 GNAS

2.78e-0381693GO:0035254
GeneOntologyMolecularFunctionRNA polymerase II CTD heptapeptide repeat modifying activity

CDK12 BRD4

2.84e-0323692GO:0140994
GeneOntologyMolecularFunctionS-adenosylmethionine-dependent methyltransferase activity

SETD1B KMT2B KMT2A NSD3

2.97e-03172694GO:0008757
GeneOntologyMolecularFunctionprotein kinase A regulatory subunit binding

WASF1 PRRC1

3.35e-0325692GO:0034237
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

FEZF1 YLPM1 ZFHX3 IRX1 THAP1

4.99e-03320695GO:0001227
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

FEZF1 YLPM1 ZFHX3 IRX1 THAP1

5.39e-03326695GO:0001217
GeneOntologyMolecularFunctionstructural constituent of postsynapse

SHANK1 SHANK2

5.46e-0332692GO:0099186
GeneOntologyMolecularFunctionmethyltransferase activity

SETD1B KMT2B KMT2A NSD3

6.34e-03213694GO:0008168
GeneOntologyMolecularFunctionlncRNA binding

RBM33 BRD3

6.51e-0335692GO:0106222
GeneOntologyMolecularFunctiontransition metal ion binding

KMT2B ZFHX4 ZFHX2 KMT2A ZFHX3 ZNF385C MARCHF4 THAP1 RXRB IKZF4

7.44e-0311896910GO:0046914
GeneOntologyMolecularFunctiontransferase activity, transferring one-carbon groups

SETD1B KMT2B KMT2A NSD3

7.55e-03224694GO:0016741
GeneOntologyMolecularFunctionneuropeptide receptor binding

SHANK1 GNAS

8.03e-0339692GO:0071855
GeneOntologyMolecularFunctionhistone modifying activity

SETD1B KMT2B KMT2A NSD3

8.14e-03229694GO:0140993
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZFHX4 FEZF1 ATOH8 YLPM1 ZFHX2 ZFHX3 IRF5 IRX1 THAP1 RXRB HOMEZ

8.72e-0314126911GO:0000981
GeneOntologyMolecularFunctionstructural constituent of synapse

SHANK1 SHANK2

9.27e-0342692GO:0098918
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZFHX4 FEZF1 ATOH8 ZFHX2 ZFHX3 IRF5 IRX1 THAP1 RXRB IKZF4

1.01e-0212446910GO:0000978
GeneOntologyMolecularFunctionprotein domain specific binding

SHANK1 SHANK2 WAS SCAF8 SH3BP1 RDX GNAS IKZF4

1.04e-02875698GO:0019904
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZFHX4 FEZF1 ATOH8 ZFHX2 ZFHX3 IRF5 IRX1 THAP1 RXRB IKZF4

1.16e-0212716910GO:0000987
GeneOntologyBiologicalProcessregulation of actin filament organization

SHANK1 EPS8 LATS1 WAS CARMIL3 WASHC1 SH3BP1 RDX FHOD3 WASF1

5.04e-083006810GO:0110053
GeneOntologyBiologicalProcessactin filament organization

SHANK1 EPS8 SHROOM3 LATS1 WAS CARMIL3 WASHC1 SH3BP1 FMN2 RDX FHOD3 WASF1

9.30e-085096812GO:0007015
GeneOntologyBiologicalProcessregulation of actin cytoskeleton organization

SHANK1 EPS8 LATS1 WAS CARMIL3 WASHC1 SH3BP1 RDX FHOD3 WASF1

4.95e-073846810GO:0032956
GeneOntologyBiologicalProcessactin polymerization or depolymerization

EPS8 LATS1 WAS WASHC1 SH3BP1 RDX FHOD3 WASF1

6.74e-07222688GO:0008154
GeneOntologyBiologicalProcessregulation of actin filament-based process

SHANK1 EPS8 LATS1 WAS CARMIL3 WASHC1 SH3BP1 RDX FHOD3 WASF1

1.63e-064386810GO:0032970
GeneOntologyBiologicalProcessregulation of supramolecular fiber organization

SHANK1 EPS8 LATS1 WAS CARMIL3 WASHC1 SH3BP1 RDX FHOD3 WASF1

1.63e-064386810GO:1902903
GeneOntologyBiologicalProcessactin cytoskeleton organization

SHANK1 EPS8 SHROOM3 LATS1 WAS CARMIL3 IQSEC2 WASHC1 SH3BP1 FMN2 RDX FHOD3 WASF1

1.85e-068036813GO:0030036
GeneOntologyBiologicalProcessregulation of actin polymerization or depolymerization

EPS8 LATS1 WAS WASHC1 SH3BP1 RDX FHOD3

1.90e-06177687GO:0008064
GeneOntologyBiologicalProcessregulation of actin filament length

EPS8 LATS1 WAS WASHC1 SH3BP1 RDX FHOD3

2.12e-06180687GO:0030832
GeneOntologyBiologicalProcessactin filament polymerization

EPS8 LATS1 WAS WASHC1 RDX FHOD3 WASF1

3.04e-06190687GO:0030041
GeneOntologyBiologicalProcessactin filament-based process

SHANK1 EPS8 SHROOM3 LATS1 WAS CARMIL3 IQSEC2 WASHC1 SH3BP1 FMN2 RDX FHOD3 WASF1

7.43e-069126813GO:0030029
GeneOntologyBiologicalProcessnegative regulation of termination of RNA polymerase II transcription, poly(A)-coupled

SCAF8 SCAF4

1.07e-052682GO:2000805
GeneOntologyBiologicalProcessnegative regulation of termination of RNA polymerase II transcription

SCAF8 SCAF4

1.07e-052682GO:0120191
GeneOntologyBiologicalProcesssupramolecular fiber organization

SHANK1 EPS8 SHROOM3 LATS1 WAS CARMIL3 WASHC1 SH3BP1 FMN2 RDX SMN1 FHOD3 WASF1

1.24e-059576813GO:0097435
GeneOntologyBiologicalProcessregulation of cytoskeleton organization

SHANK1 EPS8 LATS1 WAS CARMIL3 WASHC1 SH3BP1 RDX FHOD3 WASF1

1.89e-055796810GO:0051493
GeneOntologyBiologicalProcessnegative regulation of termination of DNA-templated transcription

SCAF8 SCAF4

3.21e-053682GO:0060567
GeneOntologyBiologicalProcesstermination of RNA polymerase II transcription, poly(A)-coupled

SCAF8 SCAF4

3.21e-053682GO:0030846
GeneOntologyBiologicalProcessregulation of termination of RNA polymerase II transcription, poly(A)-coupled

SCAF8 SCAF4

3.21e-053682GO:2000804
GeneOntologyBiologicalProcessactivation of protein kinase A activity

FBN1 PRRC1

3.21e-053682GO:0034199
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

FEZF1 SCAF8 ATOH8 YLPM1 SMARCC2 MAGEC3 ZFHX3 IRX1 TSC22D4 SPEN ZC3H6 THAP1 IKZF4 NSD3 SCAF4

3.99e-0513996815GO:0045892
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

FEZF1 SCAF8 ATOH8 YLPM1 SMARCC2 MAGEC3 ZFHX3 IRX1 TSC22D4 SPEN ZC3H6 THAP1 IKZF4 NSD3 SCAF4

4.48e-0514136815GO:1902679
GeneOntologyBiologicalProcessprotein-containing complex disassembly

EPS8 SCAF8 SH3BP1 SMARCC2 RDX SMN1 SCAF4

4.81e-05291687GO:0032984
GeneOntologyBiologicalProcesspositive regulation of DNA-templated transcription, elongation

MED15 CDK12 SCAF8 BRD4

5.22e-0562684GO:0032786
GeneOntologyBiologicalProcessactin nucleation

CARMIL3 WASHC1 FMN2 WASF1

6.29e-0565684GO:0045010
GeneOntologyBiologicalProcessregulation of termination of RNA polymerase II transcription

SCAF8 SCAF4

6.40e-054682GO:1904594
GeneOntologyBiologicalProcessregulation of protein-containing complex disassembly

EPS8 SCAF8 SH3BP1 RDX SCAF4

1.13e-04144685GO:0043244
GeneOntologyBiologicalProcessprotein polymerization

EPS8 LATS1 WAS WASHC1 RDX FHOD3 WASF1

1.14e-04334687GO:0051258
GeneOntologyBiologicalProcessregulation of Arp2/3 complex-mediated actin nucleation

CARMIL3 WASHC1 WASF1

1.44e-0431683GO:0034315
GeneOntologyBiologicalProcessregulation of termination of DNA-templated transcription

SCAF8 SCAF4

1.59e-046682GO:0031554
GeneOntologyBiologicalProcessregulation of actin filament polymerization

EPS8 LATS1 WASHC1 RDX FHOD3

1.65e-04156685GO:0030833
GeneOntologyBiologicalProcessDNA-templated transcription termination

SCAF8 SMN1 SCAF4

1.91e-0434683GO:0006353
GeneOntologyBiologicalProcessnegative regulation of protein-containing complex disassembly

EPS8 SCAF8 RDX SCAF4

3.34e-04100684GO:0043242
GeneOntologyBiologicalProcessregulation of actin nucleation

CARMIL3 WASHC1 WASF1

3.34e-0441683GO:0051125
GeneOntologyBiologicalProcessmaintenance of postsynaptic density structure

SHANK1 SHANK2

3.80e-049682GO:0099562
GeneOntologyBiologicalProcessregulation of DNA-templated transcription elongation

MED15 CDK12 SCAF8 BRD4

4.02e-04105684GO:0032784
GeneOntologyBiologicalProcessactin filament bundle assembly

SHANK1 EPS8 WAS FMN2 RDX

4.20e-04191685GO:0051017
GeneOntologyBiologicalProcessnegative regulation of cytoskeleton organization

SHANK1 EPS8 WAS RDX FHOD3

4.51e-04194685GO:0051494
GeneOntologyBiologicalProcessactin filament bundle organization

SHANK1 EPS8 WAS FMN2 RDX

4.62e-04195685GO:0061572
GeneOntologyBiologicalProcesspolar body extrusion after meiotic divisions

WASHC1 FMN2

4.74e-0410682GO:0040038
GeneOntologyBiologicalProcessnegative regulation of supramolecular fiber organization

SHANK1 EPS8 WAS RDX FHOD3

4.84e-04197685GO:1902904
GeneOntologyBiologicalProcessregulation of cellular component size

EPS8 LATS1 WAS WASHC1 SH3BP1 RDX FHOD3

5.00e-04426687GO:0032535
GeneOntologyBiologicalProcessArp2/3 complex-mediated actin nucleation

CARMIL3 WASHC1 WASF1

5.01e-0447683GO:0034314
GeneOntologyBiologicalProcessruffle assembly

EPS8 SH3BP1 RDX

5.01e-0447683GO:0097178
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

FEZF1 SCAF8 YLPM1 SMARCC2 MAGEC3 ZFHX3 IRX1 TSC22D4 SPEN THAP1 SCAF4

6.15e-0410536811GO:0000122
GeneOntologyBiologicalProcesspositive regulation of transcription elongation by RNA polymerase II

MED15 CDK12 BRD4

7.54e-0454683GO:0032968
GeneOntologyBiologicalProcessmeiotic cytokinesis

WASHC1 FMN2

8.16e-0413682GO:0033206
GeneOntologyBiologicalProcessassociative learning

SHANK1 RIN1 SHANK2 KMT2A

8.98e-04130684GO:0008306
GeneOntologyBiologicalProcesscellular component disassembly

EPS8 SCAF8 WASHC1 SH3BP1 SMARCC2 RDX SMN1 SCAF4

9.33e-04617688GO:0022411
GeneOntologyBiologicalProcessregulation of protein polymerization

EPS8 LATS1 WASHC1 RDX FHOD3

9.91e-04231685GO:0032271
GeneOntologyBiologicalProcessRac protein signal transduction

EPS8 SH3BP1 WASF1

1.03e-0360683GO:0016601
GeneOntologyBiologicalProcessregulation of actin filament depolymerization

EPS8 SH3BP1 RDX

1.08e-0361683GO:0030834
GeneOntologyBiologicalProcessruffle organization

EPS8 SH3BP1 RDX

1.08e-0361683GO:0031529
GeneOntologyBiologicalProcesstermination of RNA polymerase II transcription

SCAF8 SCAF4

1.25e-0316682GO:0006369
GeneOntologyBiologicalProcessprotein depolymerization

EPS8 SH3BP1 RDX SMN1

1.31e-03144684GO:0051261
GeneOntologyBiologicalProcessDNA-templated transcription elongation

MED15 CDK12 SCAF8 BRD4

1.31e-03144684GO:0006354
GeneOntologyBiologicalProcessregulation of organelle organization

SHANK1 EPS8 LATS1 WAS CARMIL3 WASHC1 YLPM1 SH3BP1 SMARCC2 RDX FHOD3 WASF1

1.34e-0313426812GO:0033043
GeneOntologyBiologicalProcessactin filament depolymerization

EPS8 SH3BP1 RDX

1.35e-0366683GO:0030042
GeneOntologyBiologicalProcessmaintenance of postsynaptic specialization structure

SHANK1 SHANK2

1.41e-0317682GO:0098880
GeneOntologyBiologicalProcessapical protein localization

SHROOM3 RDX

1.41e-0317682GO:0045176
GeneOntologyBiologicalProcesscell morphogenesis

SHANK1 EPS8 SHROOM3 LATS1 RAPH1 FEZF1 RDX ROBO2 SMN1 TSC22D4 WASF1

1.71e-0311946811GO:0000902
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

MED15 WAS PELP1 CDK12 ATOH8 BRD4 KMT2A ZFHX3 IRF5 BRD3 RXRB IKZF4

1.80e-0313906812GO:0045944
GeneOntologyBiologicalProcessnegative regulation of actin filament polymerization

EPS8 RDX FHOD3

1.95e-0375683GO:0030837
GeneOntologyCellularComponentcell leading edge

EPS8 RAPH1 CARMIL3 WASHC1 SH3BP1 RDX ROBO2 GNAS WASF1

4.25e-05500709GO:0031252
GeneOntologyCellularComponentchromatin

ZFHX4 PELP1 ATOH8 BRD4 ZFHX2 SMARCC2 ZFHX3 IRF5 BRD3 IRX1 ZC3H6 THAP1 RXRB NSD3 HOMEZ

9.29e-0514807015GO:0000785
GeneOntologyCellularComponenthistone methyltransferase complex

SETD1B KMT2B PELP1 KMT2A

1.17e-0475704GO:0035097
GeneOntologyCellularComponentlamellipodium

RAPH1 CARMIL3 WASHC1 SH3BP1 RDX WASF1

1.21e-04230706GO:0030027
GeneOntologyCellularComponentMLL1/2 complex

KMT2B PELP1 KMT2A

1.83e-0433703GO:0044665
GeneOntologyCellularComponentcell cortex

EPS8 SHROOM3 IQSEC2 WASHC1 SH3BP1 FMN2 RDX

2.40e-04371707GO:0005938
GeneOntologyCellularComponentcyclin/CDK positive transcription elongation factor complex

CDK12 BRD4

3.92e-049702GO:0008024
GeneOntologyCellularComponentmethyltransferase complex

SETD1B KMT2B PELP1 KMT2A

4.75e-04108704GO:0034708
GeneOntologyCellularComponentnuclear body

SETD1B RAPH1 PRPF40B CDK12 ATOH8 YLPM1 SMN1 ZFHX3 THAP1 IKZF4

8.13e-049037010GO:0016604
GeneOntologyCellularComponentnuclear cyclin-dependent protein kinase holoenzyme complex

CDK12 BRD4

1.63e-0318702GO:0019908
GeneOntologyCellularComponentnuclear protein-containing complex

MED15 SF3B4 SETD1B KMT2B PELP1 PRPF40B CDK12 SCAF8 BRD4 KMT2A SMARCC2 RXRB

1.92e-0313777012GO:0140513
GeneOntologyCellularComponentexocyst

WASHC1 SH3BP1

2.23e-0321702GO:0000145
GeneOntologyCellularComponentactin-based cell projection

EPS8 RAPH1 WASHC1 FMN2 RDX

2.40e-03278705GO:0098858
DomainPost-SET_dom

SETD1B KMT2B KMT2A NSD3

3.00e-0716694IPR003616
DomainPostSET

SETD1B KMT2B KMT2A NSD3

3.00e-0716694SM00508
DomainPOST_SET

SETD1B KMT2B KMT2A NSD3

3.00e-0716694PS50868
DomainRRM

SF3B4 RBM12 SETD1B RBM33 SCAF8 RBM26 SPEN SCAF4

1.33e-06217698SM00360
DomainWH2

WAS WASHC1 WASH2P WASF1

1.71e-0624694PS51082
DomainRRM_dom

SF3B4 RBM12 SETD1B RBM33 SCAF8 RBM26 SPEN SCAF4

1.86e-06227698IPR000504
DomainRRM

SF3B4 RBM12 SETD1B RBM33 SCAF8 RBM26 SPEN SCAF4

2.05e-06230698PS50102
Domain-

SF3B4 RBM12 SETD1B RBM33 SCAF8 RBM26 SPEN SCAF4

3.18e-062446983.30.70.330
DomainNucleotide-bd_a/b_plait

SF3B4 RBM12 SETD1B RBM33 SCAF8 RBM26 SPEN SCAF4

4.80e-06258698IPR012677
DomainRRM_1

SF3B4 RBM12 SETD1B SCAF8 RBM26 SPEN SCAF4

1.15e-05208697PF00076
DomainMeTrfase_trithorax

KMT2B KMT2A

1.35e-052692IPR016569
DomainSET

SETD1B KMT2B KMT2A NSD3

1.56e-0541694PF00856
DomainSET

SETD1B KMT2B KMT2A NSD3

2.48e-0546694SM00317
DomainSET_dom

SETD1B KMT2B KMT2A NSD3

3.46e-0550694IPR001214
DomainSET

SETD1B KMT2B KMT2A NSD3

3.46e-0550694PS50280
DomainWH2_dom

WAS WASH2P WASF1

6.12e-0521693IPR003124
DomainBET

BRD4 BRD3

8.03e-054692PF17035
DomainNET_dom

BRD4 BRD3

8.03e-054692IPR027353
DomainNET

BRD4 BRD3

8.03e-054692PS51525
DomainFYrich_C

KMT2B KMT2A

1.34e-045692IPR003889
DomainFYrich_N

KMT2B KMT2A

1.34e-045692IPR003888
DomainFYRC

KMT2B KMT2A

1.34e-045692SM00542
DomainFYRN

KMT2B KMT2A

1.34e-045692SM00541
DomainFYRN

KMT2B KMT2A

1.34e-045692PF05964
DomainFYRC

KMT2B KMT2A

1.34e-045692PF05965
DomainFYRC

KMT2B KMT2A

1.34e-045692PS51543
DomainFYRN

KMT2B KMT2A

1.34e-045692PS51542
DomainZnF_U1

ZFHX4 ZFHX2 ZFHX3

1.65e-0429693SM00451
DomainZnf_U1

ZFHX4 ZFHX2 ZFHX3

1.65e-0429693IPR003604
DomainRNA_pol_II-bd

SCAF8 SCAF4

2.79e-047692IPR006903
DomainCTD_bind

SCAF8 SCAF4

2.79e-047692PF04818
DomainRPR

SCAF8 SCAF4

3.71e-048692SM00582
DomainCID

SCAF8 SCAF4

3.71e-048692PS51391
DomainCID_dom

SCAF8 SCAF4

3.71e-048692IPR006569
DomainBROMODOMAIN_2

BRD4 KMT2A BRD3

4.65e-0441693PS50014
DomainBROMO

BRD4 KMT2A BRD3

5.00e-0442693SM00297
DomainBromodomain

BRD4 KMT2A BRD3

5.00e-0442693IPR001487
Domain-

BRD4 KMT2A BRD3

5.00e-04426931.20.920.10
Domain-

ZFHX4 ZFHX2 SMARCC2 ZFHX3 IRX1 HOMEZ

6.18e-042836961.10.10.60
DomainZnf_CXXC

KMT2B KMT2A

7.24e-0411692IPR002857
DomainZF_CXXC

KMT2B KMT2A

7.24e-0411692PS51058
Domainzf-CXXC

KMT2B KMT2A

7.24e-0411692PF02008
DomainWH2

WAS WASF1

1.19e-0314692SM00246
DomainFH2

FMN2 FHOD3

1.37e-0315692PS51444
DomainFH2_Formin

FMN2 FHOD3

1.37e-0315692IPR015425
DomainFH2

FMN2 FHOD3

1.37e-0315692PF02181
DomainFH2

FMN2 FHOD3

1.37e-0315692SM00498
DomainHomeodomain-like

ZFHX4 ZFHX2 SMARCC2 ZFHX3 IRX1 HOMEZ

1.41e-03332696IPR009057
DomainWH2

WAS WASF1

1.56e-0316692PF02205
DomainHomeobox_KN

IRX1 HOMEZ

1.76e-0317692PF05920
DomainHomeobox_KN_domain

IRX1 HOMEZ

1.76e-0317692IPR008422
DomainHOMEOBOX_1

ZFHX4 ZFHX2 ZFHX3 IRX1 HOMEZ

1.80e-03236695PS00027
DomainHOX

ZFHX4 ZFHX2 ZFHX3 IRX1 HOMEZ

1.83e-03237695SM00389
DomainHOMEOBOX_2

ZFHX4 ZFHX2 ZFHX3 IRX1 HOMEZ

1.90e-03239695PS50071
DomainHomeobox_dom

ZFHX4 ZFHX2 ZFHX3 IRX1 HOMEZ

1.90e-03239695IPR001356
DomainPHD

KMT2B KMT2A NSD3

2.69e-0375693PF00628
DomainEPHD

KMT2B KMT2A

2.96e-0322692PS51805
DomainZnf_PHD-finger

KMT2B KMT2A NSD3

3.12e-0379693IPR019787
DomainBromodomain_CS

BRD4 BRD3

4.13e-0326692IPR018359
Domain-

SCAF8 SCAF4

4.13e-03266921.25.40.90
DomainPHD

KMT2B KMT2A NSD3

4.37e-0389693SM00249
DomainAT_hook

KMT2B KMT2A

4.45e-0327692SM00384
DomainAT_hook_DNA-bd_motif

KMT2B KMT2A

4.45e-0327692IPR017956
DomainZnf_PHD

KMT2B KMT2A NSD3

4.65e-0391693IPR001965
PathwayREACTOME_PKMTS_METHYLATE_HISTONE_LYSINES

SETD1B KMT2B KMT2A NSD3

1.12e-0546434MM14933
PathwayWP_MRNA_PROCESSING

SF3B4 RBM12 PRPF40B RBM33 SCAF8 RBM26 SMN1 SPEN

5.58e-05451438MM15946
PathwayREACTOME_PKMTS_METHYLATE_HISTONE_LYSINES

SETD1B KMT2B KMT2A NSD3

5.94e-0570434M27231
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

SETD1B KMT2B KMT2A SMARCC2 NSD3

1.83e-04175435MM14941
PathwayREACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES

SETD1B KMT2B KMT2A

2.07e-0438433MM17073
PathwayREACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES

SETD1B KMT2B KMT2A

2.79e-0442433M48018
PathwayREACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION

SETD1B KMT2B KMT2A

3.21e-0444433MM15527
Pubmed

Human transcription factor protein interaction networks.

MED15 FBN1 RBM12 KMT2B ZFHX4 RBM33 SCAF8 YLPM1 KMT2A DLAT SMARCC2 SMN1 ZFHX3 IRF5 R3HDM1 SPEN SCAF4 HOMEZ

3.93e-101429711835140242
Pubmed

WW domains provide a platform for the assembly of multiprotein networks.

SF3B4 WAS CDK12 BRD4 YLPM1 SMARCC2 PRRC1 SCAF4

1.03e-0915471816055720
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

MED15 LATS1 KMT2B RAPH1 CDK12 BRD4 YLPM1 RBM26 KMT2A SPEN NSD3 SCAF4

1.17e-09549711238280479
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

LATS1 KMT2B RAPH1 CDK12 SCAF8 BRD4 YLPM1 KMT2A SMARCC2 BRD3 SPEN SCAF4 HOMEZ

5.27e-09774711315302935
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

EPS8 SF3B4 KMT2B RAPH1 RBM33 CDK12 BRD4 YLPM1 FMN2 SMARCC2 SCAF4

6.47e-09506711130890647
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

SHROOM3 SF3B4 LATS1 RAPH1 BRD4 IQSEC2 FMN2 KMT2A GNAS TSC22D4 R3HDM1 PRRC1 NSD3

1.85e-08861711336931259
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

SHROOM3 SF3B4 CDK12 SCAF8 BRD4 YLPM1 SMARCC2 SMN1 GNAS THAP1 RXRB

2.71e-08582711120467437
Pubmed

Behavioral abnormalities observed in Zfhx2-deficient mice.

ZFHX4 ZFHX2 ZFHX3

3.26e-08471323300874
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

MED15 EPS8 SHROOM3 KMT2B SHANK2 RBM33 CDK12 SCAF8 RBM26 KMT2A SMN1 ZFHX3 BRD3 SPEN NSD3 SCAF4

4.37e-081497711631527615
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

SETD1B KMT2B CDK12 RBM26 KMT2A BRD3 SPEN SCAF4

4.73e-0825171831076518
Pubmed

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.

ZFHX4 BRD4 KMT2A ZFHX3 BRD3 SPEN

7.13e-0810371632744500
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

MED15 RBM12 RBM33 BRD4 YLPM1 RBM26 KMT2A SMARCC2

7.83e-0826871833640491
Pubmed

Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.

SETD1B KMT2B KMT2A

8.13e-08571325561738
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

MED15 SHROOM3 SF3B4 RBM33 SCAF8 YLPM1 R3HDM1

8.90e-0818071735198878
Pubmed

Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.

SETD1B KMT2B KMT2A

4.53e-07871323130995
Pubmed

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

SETD1B KMT2B KMT2A

4.53e-07871322266653
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

SF3B4 PELP1 RBM33 CDK12 BRD4 YLPM1 RBM26 KMT2A SMARCC2 SPEN NSD3 SCAF4

4.90e-07954711236373674
Pubmed

Interaction network of human early embryonic transcription factors.

MED15 KMT2B ZFHX4 KMT2A SMARCC2 ZFHX3 SPEN HOMEZ

6.08e-0735171838297188
Pubmed

Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.

SETD1B KMT2B KMT2A

6.79e-07971322665483
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

MED15 SF3B4 RBM12 PELP1 RBM33 R3HDM1

7.15e-0715271638360978
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

ATOH8 BRD4 ZFHX2 KMT2A ZFHX3 IRF5 BRD3 TSC22D4 RXRB IKZF4

1.75e-06709711022988430
Pubmed

Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.

SETD1B KMT2B KMT2A

1.77e-061271327563068
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

RBM33 CDK12 BRD4 YLPM1 RBM26 ZFHX3 SPEN

1.87e-0628371730585729
Pubmed

A census of human transcription factors: function, expression and evolution.

ZFHX4 ATOH8 ZFHX2 KMT2A ZFHX3 IRF5 IRX1 TSC22D4 THAP1 RXRB HOMEZ

2.22e-06908711119274049
Pubmed

Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.

MED15 SF3B4 PELP1 RBM33 CDK12 KMT2A SMARCC2 R3HDM1

2.53e-0642571824999758
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

SHANK1 SHROOM3 SHANK2 PELP1 IQSEC2 YLPM1 SH3BP1 SMARCC2 RDX WASF1 WNK2

3.89e-06963711128671696
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

MED15 KMT2B SMARCC2 ROBO2 TSC22D4 R3HDM1 SPEN THAP1 WNK2

4.08e-0660871916713569
Pubmed

Hierarchical regulation of WASP/WAVE proteins.

WAS WASF1

4.11e-06271218995840
Pubmed

KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions.

KMT2B KMT2A

4.11e-06271228723559
Pubmed

An IRF5 Decoy Peptide Reduces Myocardial Inflammation and Fibrosis and Improves Endothelial Cell Function in Tight-Skin Mice.

FBN1 IRF5

4.11e-06271227050551
Pubmed

WASP and SCAR are evolutionarily conserved in actin-filled pseudopod-based motility.

WAS WASF1

4.11e-06271228473602
Pubmed

4F decreases IRF5 expression and activation in hearts of tight skin mice.

FBN1 IRF5

4.11e-06271223251680
Pubmed

Identification of Wiskott-Aldrich syndrome protein (WASP) binding sites on the branched actin filament nucleator Arp2/3 complex.

WAS WASF1

4.11e-06271229386393
Pubmed

BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis.

BRD4 BRD3

4.11e-06271228733670
Pubmed

The mouse ZFH-4 protein contains four homeodomains and twenty-two zinc fingers.

ZFHX4 ZFHX3

4.11e-06271210873665
Pubmed

SCAF4 and SCAF8, mRNA Anti-Terminator Proteins.

SCAF8 SCAF4

4.11e-06271231104839
Pubmed

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairments.

SHANK1 SHANK2

4.11e-06271225188300
Pubmed

Recruitment of Brd3 and Brd4 to acetylated chromatin is essential for proinflammatory cytokine-induced matrix-degrading enzyme expression.

BRD4 BRD3

4.11e-06271230786900
Pubmed

BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells.

BRD4 BRD3

4.11e-06271229240787
Pubmed

A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins.

BRD3 NSD3

4.11e-06271233592170
Pubmed

SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.

SETD1B KMT2B KMT2A

4.48e-061671323870121
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

SF3B4 KMT2B SHANK2 BRD4 SMARCC2 SPEN WNK2

5.03e-0632971717474147
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

EPS8 SETD1B SCAF8 CARMIL3 WASHC1 SH3BP1 FMN2 RDX

5.72e-0647571831040226
Pubmed

A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.

SF3B4 RBM12 SETD1B SCAF8 RBM26 SPEN SCAF4

7.12e-0634771716033648
Pubmed

A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.

SETD1B KMT2B KMT2A SMARCC2

7.62e-066171420305087
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

SF3B4 KMT2B PELP1 BRD4 YLPM1 KMT2A BRD3 SPEN THAP1 NSD3 SCAF4 HOMEZ

1.13e-051294711230804502
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

VPS37C SF3B4 CDK12 BRD4 YLPM1 SMARCC2 BRD3 SPEN ZC3H6 NSD3 SCAF4

1.17e-051082711138697112
Pubmed

Structural basis for activity regulation of MLL family methyltransferases.

SETD1B KMT2B KMT2A

1.22e-052271326886794
Pubmed

The Shank family of scaffold proteins.

SHANK1 SHANK2

1.23e-05371210806096
Pubmed

SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling.

LATS1 SHANK2

1.23e-05371232661924
Pubmed

Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton.

SHANK1 SHANK2

1.23e-05371211583995
Pubmed

N-WASP involvement in dorsal ruffle formation in mouse embryonic fibroblasts.

WAS WASF1

1.23e-05371217182853
Pubmed

Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin.

SHANK1 SHANK2

1.23e-05371210433268
Pubmed

Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins.

SHANK1 SHANK2

1.23e-05371210433269
Pubmed

Translational neurobiology in Shank mutant mice--model systems for neuropsychiatric disorders.

SHANK1 SHANK2

1.23e-05371225917711
Pubmed

Snapshots of the RNA processing factor SCAF8 bound to different phosphorylated forms of the carboxyl-terminal domain of RNA polymerase II.

SCAF8 SCAF4

1.23e-05371218550522
Pubmed

Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system.

BRD4 BRD3

1.23e-05371231792058
Pubmed

Critical conformational changes in the Arp2/3 complex are induced by nucleotide and nucleation promoting factor.

WAS WASF1

1.23e-05371215494313
Pubmed

BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.

BRD4 BRD3

1.23e-05371217934517
Pubmed

Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation.

BRD4 BRD3

1.23e-05371231119153
Pubmed

Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo.

RAPH1 WASF1

1.23e-05371224247431
Pubmed

Modeling autism by SHANK gene mutations in mice.

SHANK1 SHANK2

1.23e-05371223583105
Pubmed

Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration.

BRD4 BRD3

1.23e-05371224049186
Pubmed

Dynamic Change of Shanks Gene mRNA Expression and DNA Methylation in Epileptic Rat Model and Human Patients.

SHANK1 SHANK2

1.23e-05371232564287
Pubmed

BET Proteins Exhibit Transcriptional and Functional Opposition in the Epithelial-to-Mesenchymal Transition.

BRD4 BRD3

1.23e-05371229437854
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

MED15 PELP1 RBM33 BRD4 KMT2A SMARCC2 BRD3 NSD3

1.32e-0553371830554943
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

MED15 RBM12 KMT2B RBM33 BRD4 RBM26 KMT2A SMARCC2 SPEN SCAF4 HOMEZ

1.39e-051103711134189442
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

PELP1 BRD4 RBM26 KMT2A SMARCC2 BRD3 NSD3

1.62e-0539471727248496
Pubmed

Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.

ZFHX4 ZFHX2 ZFHX3 BRD3 RXRB IKZF4

1.68e-0526371620932939
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

SF3B4 RBM12 RBM33 BRD4 YLPM1 RBM26 SMARCC2

1.76e-0539971735987950
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

LATS1 SETD1B KMT2B CDK12 BRD4 KMT2A BRD3 WNK2 NSD3

1.76e-0573071934857952
Pubmed

Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation.

WAS WASHC1

2.46e-05471232492429
Pubmed

SHANK3 gene mutations associated with autism facilitate ligand binding to the Shank3 ankyrin repeat region.

SHANK1 SHANK2

2.46e-05471223897824
Pubmed

Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4.

BRD4 NSD3

2.46e-05471229176719
Pubmed

Expression of BET genes in testis of men with different spermatogenic impairments.

BRD4 BRD3

2.46e-05471222035730
Pubmed

A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.

KMT2B KMT2A

2.46e-05471223129768
Pubmed

Cross-talk between histone modifications in response to histone deacetylase inhibitors: MLL4 links histone H3 acetylation and histone H3K4 methylation.

KMT2B KMT2A

2.46e-05471217166833
Pubmed

Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA.

KMT2B KMT2A

2.46e-05471234156981
Pubmed

WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket.

KMT2B KMT2A

2.46e-05471218840606
Pubmed

NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism.

BRD4 NSD3

2.46e-05471224875858
Pubmed

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes.

KMT2B KMT2A

2.46e-05471226267306
Pubmed

Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly.

EPS8 WAS

2.46e-05471222921828
Pubmed

Regulation of NO synthesis, local inflammation, and innate immunity to pathogens by BET family proteins.

BRD4 BRD3

2.46e-05471224248598
Pubmed

Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma.

BRD4 BRD3

2.46e-05471226623725
Pubmed

MLL1 is required for PAX7 expression and satellite cell self-renewal in mice.

KMT2B KMT2A

2.46e-05471231534153
Pubmed

HOXA9/IRX1 expression pattern defines two subgroups of infant MLL-AF4-driven acute lymphoblastic leukemia.

KMT2A IRX1

2.46e-05471233069783
Pubmed

The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42.

SHANK1 SHANK2

2.46e-05471212626503
Pubmed

Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors.

BRD4 BRD3

2.46e-05471222912406
Pubmed

Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory.

KMT2B KMT2A

2.46e-05471225834037
Pubmed

Interaction between Wiskott-Aldrich Syndrome protein (WASP) and the Fyn protein-tyrosine kinase.

WAS WASF1

2.46e-05471210532312
Pubmed

Motility determinants in WASP family proteins.

WAS WASF1

2.46e-05471212429845
Pubmed

The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity.

SHANK1 EPS8 SHANK2

2.87e-052971319208628
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

SHANK1 RIN1 EPS8 SHANK2 IQSEC2 KMT2A DLAT SMARCC2 RDX TSC22D4 WASF1 WNK2

3.04e-051431711237142655
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

KMT2B BRD4 KMT2A SMARCC2 BRD3 SPEN NSD3 HOMEZ

3.37e-0560871836089195
Pubmed

Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes.

SBK1 WAS YLPM1

3.52e-053171319041431
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

MED15 RBM12 CDK12 BRD4 YLPM1 RBM26 KMT2A SMARCC2 BRD3 NSD3

3.92e-051014711032416067
Pubmed

Evolving Catalytic Properties of the MLL Family SET Domain.

KMT2B KMT2A

4.09e-05571226320581
Pubmed

Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor.

SHANK1 SHANK2

4.09e-05571216606358
Pubmed

Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse.

LATS1 GNAS

4.09e-05571231474569
Pubmed

Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization.

WAS WASF1

4.09e-05571210563804
InteractionPRPF40A interactions

SF3B4 KMT2B WAS PELP1 CDK12 BRD4 YLPM1 SMARCC2 ZFHX3 BRD3 SPEN WASF1 SCAF4

4.65e-094467113int:PRPF40A
InteractionTLE3 interactions

MED15 RBM12 PRPF40B CDK12 SCAF8 BRD4 KMT2A SMARCC2 ZFHX3 SPEN SCAF4

7.75e-083767111int:TLE3
InteractionTRIP10 interactions

SBK1 RIN1 WAS SH3BP1 SMARCC2 WASF1 THAP1

1.11e-07109717int:TRIP10
InteractionACTC1 interactions

EPS8 SF3B4 KMT2B WAS RAPH1 RBM33 CDK12 BRD4 YLPM1 FMN2 SMARCC2 WNK2 SCAF4

7.90e-076947113int:ACTC1
InteractionPRMT2 interactions

SHANK1 RBM12 SETD1B IQSEC2 YLPM1 R3HDM1

8.12e-0791716int:PRMT2
InteractionSP7 interactions

RBM12 KMT2B ZFHX4 RBM33 SCAF8 YLPM1 SMARCC2 SCAF4 HOMEZ

1.18e-06304719int:SP7
InteractionSNRNP40 interactions

KMT2B PELP1 PRPF40B CDK12 SCAF8 BRD4 KMT2A SMARCC2 ZFHX3 SPEN NSD3 SCAF4

2.09e-066377112int:SNRNP40
InteractionNUP50 interactions

RBM33 CDK12 BRD4 RBM26 KMT2A SMARCC2 RDX SPEN NSD3

3.03e-06341719int:NUP50
InteractionNCK2 interactions

SF3B4 WAS RAPH1 GGN YLPM1 RBM26 WASF1 HOMEZ

3.85e-06262718int:NCK2
InteractionYWHAH interactions

RIN1 SHROOM3 LATS1 BRD4 IQSEC2 FMN2 KMT2A TSC22D4 R3HDM1 MARCHF4 WASF1 PRRC1 WNK2 NSD3 HOMEZ

5.41e-0611027115int:YWHAH
InteractionBAIAP2 interactions

SHANK1 EPS8 SF3B4 SHANK2 BRD4 RBM26 WASF1

6.85e-06201717int:BAIAP2
InteractionRBBP5 interactions

SETD1B KMT2B WAS PELP1 BRD4 KMT2A SMARCC2 SPEN

7.51e-06287718int:RBBP5
InteractionARHGAP9 interactions

SMARCC2 SMN1 TSC22D4 HOMEZ

2.25e-0547714int:ARHGAP9
InteractionYAP1 interactions

MED15 LATS1 KMT2B CDK12 BRD4 YLPM1 RBM26 KMT2A DLAT SMARCC2 GNAS SPEN NSD3 SCAF4

2.37e-0510957114int:YAP1
InteractionYWHAG interactions

RIN1 SHROOM3 SF3B4 LATS1 RAPH1 CDK12 IQSEC2 FMN2 KMT2A GNAS TSC22D4 R3HDM1 WASF1 PRRC1 HOMEZ

2.38e-0512487115int:YWHAG
InteractionSMC5 interactions

SF3B4 PELP1 RBM33 CDK12 BRD4 YLPM1 RBM26 KMT2A SMARCC2 SMN1 SPEN NSD3 SCAF4

4.07e-0510007113int:SMC5
InteractionYWHAZ interactions

RIN1 SHROOM3 LATS1 RAPH1 BRD4 IQSEC2 RBM26 KMT2A DLAT BRD3 TSC22D4 R3HDM1 WASF1 WNK2 HOMEZ

4.52e-0513197115int:YWHAZ
InteractionTBR1 interactions

LATS1 ZFHX4 BRD4 ZFHX3 BRD3

4.92e-05113715int:TBR1
InteractionNUP43 interactions

FBN1 SETD1B KMT2B PELP1 CDK12 RBM26 KMT2A ZFHX3 SPEN NSD3

6.43e-056257110int:NUP43
InteractionCELF1 interactions

RBM12 RBM33 SCAF8 BRD4 YLPM1 R3HDM1 SCAF4

6.89e-05288717int:CELF1
InteractionHCFC1 interactions

MED15 SETD1B KMT2B PELP1 BRD4 KMT2A THAP1

7.67e-05293717int:HCFC1
InteractionP4HA1 interactions

SF3B4 RBM12 PRPF40B BRD4 YLPM1 SMN1 TSC22D4

8.53e-05298717int:P4HA1
InteractionARHGAP12 interactions

SHANK2 RAPH1 YLPM1 WASF1

9.72e-0568714int:ARHGAP12
InteractionCCNK interactions

CDK12 BRD4 TSC22D4 RXRB HOMEZ

1.03e-04132715int:CCNK
InteractionGRB2 interactions

VPS37C EPS8 SF3B4 WAS RBM33 GGN YLPM1 SH3BP1 IRF5 WASF1 HOMEZ

1.12e-048067111int:GRB2
InteractionKMT2A interactions

MED15 SETD1B KMT2B BRD4 KMT2A SMARCC2 BRD3

1.18e-04314717int:KMT2A
InteractionTHOC2 interactions

KMT2B CDK12 BRD4 BRD3 GNAS SPEN

1.22e-04219716int:THOC2
InteractionRBM25 interactions

SF3B4 PRPF40B BRD4 SMARCC2 SMN1 BRD3 SPEN

1.41e-04323717int:RBM25
InteractionSETD1B interactions

SETD1B KMT2B RBM26 KMT2A

1.42e-0475714int:SETD1B
InteractionNFIX interactions

KMT2B ZFHX4 KMT2A SMARCC2 ZFHX3 SPEN

1.49e-04227716int:NFIX
InteractionDTX2 interactions

MED15 SHROOM3 SF3B4 RBM33 SCAF8 YLPM1 R3HDM1

1.60e-04330717int:DTX2
InteractionAR interactions

MED15 RBM12 PELP1 RBM33 BRD4 YLPM1 RBM26 KMT2A SMARCC2 ZFHX3 BRD3 GNAS

1.65e-049927112int:AR
InteractionBOD1L1 interactions

SETD1B KMT2B BRD4 KMT2A NSD3

1.82e-04149715int:BOD1L1
InteractionCDC5L interactions

SHROOM3 SF3B4 SCAF8 BRD4 YLPM1 SMARCC2 SMN1 GNAS SPEN THAP1 RXRB

1.87e-048557111int:CDC5L
InteractionBRDT interactions

RBM33 BRD4 SMARCC2 NSD3

1.92e-0481714int:BRDT
InteractionABI3 interactions

WAS WASHC1 SH3BP1 WASF1

1.92e-0481714int:ABI3
InteractionARHGEF7 interactions

SHANK1 LATS1 SHANK2 WAS SMARCC2

2.05e-04153715int:ARHGEF7
InteractionEYA4 interactions

MED15 SF3B4 RBM12 PELP1 RBM33 R3HDM1

2.15e-04243716int:EYA4
InteractionSLU7 interactions

RBM12 LATS1 CDK12 THAP1 NSD3

2.25e-04156715int:SLU7
InteractionKANSL3 interactions

SETD1B KMT2B BRD4 KMT2A

2.42e-0486714int:KANSL3
InteractionATXN1 interactions

MED15 KMT2B PELP1 BRD4 RBM26 DLAT SMARCC2 BRD3 GNAS R3HDM1 SPEN WNK2

2.53e-0410397112int:ATXN1
InteractionRBM10 interactions

RIN1 SF3B4 RBM12 LATS1 BRD4 THAP1

2.67e-04253716int:RBM10
InteractionCRX interactions

MED15 VPS37C ZFHX4 ZFHX3 SPEN HOMEZ

2.73e-04254716int:CRX
InteractionH3-3A interactions

SETD1B KMT2B PELP1 BRD4 KMT2A SMARCC2 BRD3 SPEN NSD3 HOMEZ

2.81e-047497110int:H3-3A
InteractionOSTF1 interactions

LATS1 GGN WASHC1 WASF1

2.88e-0490714int:OSTF1
InteractionSMARCB1 interactions

KMT2B BRD4 KMT2A SMARCC2 BRD3 TSC22D4 HOMEZ

2.92e-04364717int:SMARCB1
InteractionINO80B interactions

SCAF8 BRD4 BRD3 THAP1 HOMEZ

3.08e-04167715int:INO80B
InteractionBRD3 interactions

MED15 PRPF40B RBM33 BRD4 KMT2A SMARCC2 BRD3 NSD3

3.38e-04494718int:BRD3
InteractionC2CD5 interactions

CDK12 BRD4 BRD3 RXRB

3.54e-0495714int:C2CD5
InteractionKAT8 interactions

SETD1B KMT2B BRD4 KMT2A

3.54e-0495714int:KAT8
InteractionGEMIN5 interactions

MED15 SETD1B BRD4 KMT2A RDX SMN1

3.56e-04267716int:GEMIN5
InteractionSS18L1 interactions

SF3B4 SMARCC2 BRD3 NSD3

3.98e-0498714int:SS18L1
InteractionSMARCC1 interactions

LATS1 BRD4 YLPM1 KMT2A SMARCC2 BRD3 NSD3

4.03e-04384717int:SMARCC1
InteractionHNRNPA1 interactions

SF3B4 RBM12 RBM33 SCAF8 BRD4 YLPM1 RBM26 SMN1 TSC22D4 PRRC1 SCAF4

4.41e-049457111int:HNRNPA1
InteractionMED10 interactions

MED15 BRD4 BRD3 SCAF4

4.63e-04102714int:MED10
InteractionALG13 interactions

RBM12 LATS1 RBM33 SCAF8 R3HDM1

4.69e-04183715int:ALG13
InteractionABI2 interactions

VPS37C RAPH1 GGN WASHC1 SH3BP1 WASF1

5.12e-04286716int:ABI2
InteractionTOP3B interactions

SHROOM3 SETD1B KMT2B SHANK2 PELP1 RBM33 CDK12 BRD4 DLAT IRF5 GNAS SPEN WNK2 NSD3

5.31e-0414707114int:TOP3B
InteractionMED19 interactions

MED15 BRD4 BRD3 SCAF4

5.36e-04106714int:MED19
InteractionABCA12 interactions

BRD4 BRD3

5.41e-0410712int:ABCA12
InteractionSH3RF1 interactions

VPS37C RIN1 SHROOM3 GGN

5.75e-04108714int:SH3RF1
InteractionWBP4 interactions

SF3B4 SETD1B WAS SCAF4

5.95e-04109714int:WBP4
InteractionCHD8 interactions

PELP1 BRD4 KMT2A BRD3 NSD3

5.97e-04193715int:CHD8
InteractionSORBS2 interactions

VPS37C EPS8 WAS WASF1

6.38e-04111714int:SORBS2
InteractionCKS2 interactions

CDK12 KMT2A TSC22D4

6.87e-0449713int:CKS2
InteractionSAP18 interactions

LATS1 RBM33 BRD4 SH3BP1 SMARCC2 BRD3

7.18e-04305716int:SAP18
InteractionNUP35 interactions

MED15 RBM12 PRPF40B RBM33 CDK12 SCAF8 YLPM1

7.25e-04424717int:NUP35
InteractionPPP1CA interactions

SF3B4 LATS1 BRD4 YLPM1 PPP1R37 DLAT BRD3 PRRC1 HOMEZ

7.30e-04696719int:PPP1CA
InteractionFEV interactions

KMT2B ZFHX4 KMT2A ZFHX3 HOMEZ

7.50e-04203715int:FEV
InteractionTBXT interactions

ZFHX4 SMARCC2 SPEN HOMEZ

7.52e-04116714int:TBXT
InteractionFUBP1 interactions

VPS37C PRPF40B BRD4 SMARCC2 SMN1 SPEN

7.68e-04309716int:FUBP1
InteractionBRD9 interactions

BRD4 SMARCC2 BRD3 NSD3

7.77e-04117714int:BRD9
InteractionJMJD6 interactions

WAS SCAF8 BRD4 RBM26 SCAF4

7.84e-04205715int:JMJD6
InteractionSPDYE7P interactions

BRD4 BRD3

7.89e-0412712int:SPDYE7P
InteractionMED1 interactions

MED15 CDK12 BRD4 BRD3 SCAF4

8.01e-04206715int:MED1
InteractionTCERG1 interactions

SF3B4 WAS BRD4 SMN1 BRD3

8.18e-04207715int:TCERG1
InteractionUQCR11 interactions

CDK12 BRD4 YLPM1

8.65e-0453713int:UQCR11
InteractionPHF20 interactions

SETD1B KMT2B KMT2A

8.65e-0453713int:PHF20
InteractionAGAP2 interactions

SHANK1 SHANK2 IQSEC2 GNAS WASF1

8.73e-04210715int:AGAP2
InteractionTHOC1 interactions

MED15 RBM33 BRD4 RBM26 SPEN

8.73e-04210715int:THOC1
InteractionMED8 interactions

MED15 BRD4 KMT2A SCAF4

8.81e-04121714int:MED8
InteractionMEN1 interactions

SF3B4 SETD1B KMT2B PELP1 YLPM1 RBM26 KMT2A SMARCC2 SMN1 SPEN NSD3

8.95e-0410297111int:MEN1
InteractionSNRPC interactions

SF3B4 CDK12 BRD4 YLPM1 SMN1 SPEN SCAF4

9.00e-04440717int:SNRPC
InteractionSMG7 interactions

RBM12 LATS1 RBM33 SCAF8 YLPM1 R3HDM1

9.06e-04319716int:SMG7
InteractionCHTOP interactions

PELP1 RBM33 BRD4 SMN1 BRD3

9.11e-04212715int:CHTOP
InteractionSSTR2 interactions

SHANK1 SHANK2

9.31e-0413712int:SSTR2
InteractionHAGHL interactions

CDK12 KMT2A

9.31e-0413712int:HAGHL
InteractionANKRD2 interactions

BRD3 HOMEZ

9.31e-0413712int:ANKRD2
InteractionMLLT1 interactions

CDK12 BRD4 KMT2A SMARCC2

9.36e-04123714int:MLLT1
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZFHX4 ZFHX2 ZFHX3 HOMEZ

6.36e-0815494529
GeneFamilyWiskott-Aldrich Syndrome protein family

WAS WASHC1 WASH2P WASF1

8.46e-081649414
GeneFamilyRNA binding motif containing

SF3B4 RBM12 SETD1B RBM33 SCAF8 RBM26 SPEN SCAF4

9.69e-08213498725
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

SETD1B KMT2B KMT2A NSD3

2.08e-0634494487
GeneFamilyZinc fingers CXXC-type

KMT2B KMT2A

4.67e-0412492136
GeneFamilyPHD finger proteins

KMT2B KMT2A NSD3

1.86e-039049388
GeneFamilyZinc fingers CCCH-type

RBM26 ZC3H6

4.04e-033549273
GeneFamilyPDZ domain containing

SHANK1 SHROOM3 SHANK2

8.09e-031524931220
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

SBK1 SHANK2 ZFHX4 RAPH1 RBM33 RBM26 ZFHX2 SMARCC2 ROBO2 FHOD3 ZFHX3 IRX1 R3HDM1 WASF1 IKZF4

2.17e-0711067115M39071
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate|5w / Sample Type, Dataset, Time_group, and Cell type.

SBK1 SHANK2 ZFHX4 KMT2A ZFHX3 WNK2

8.06e-07200716c92e4fc0442404481fcac623d691dae6215b852d
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cyth3_(Cyth3)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

ATOH8 RBM26 SMARCC2 IRX1 SPEN

4.63e-0615371588ca2d2c2ab19fbee13e18951b993ee05dd30f67
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cyth3_(Cyth3)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

ATOH8 RBM26 SMARCC2 IRX1 SPEN

4.63e-06153715553dff9688a1996d8f4ba16e60c683593d781389
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GGN DUSP9 SH3BP1 PRR15 ZNF385C

6.11e-0616271593bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Cerebellum / BrainAtlas - Mouse McCarroll V32

SHANK1 SBK1 SHANK2 ZNF385C MARCHF4

7.09e-061677159efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCellCerebellum-Neuronal-Inhibitory|Cerebellum / BrainAtlas - Mouse McCarroll V32

SHANK1 SBK1 SHANK2 ZNF385C MARCHF4

7.09e-06167715904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCellfacs-Lung-nan-3m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHANK1 SBK1 WAS CARMIL3 MARCHF4

7.95e-06171715a31c23406cf6d6a17358a8fb41d392a7fb0306e0
ToppCellfacs-Lung-nan-3m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHANK1 SBK1 WAS CARMIL3 MARCHF4

7.95e-0617171543d8fd9b9546e84a652564fe96b514b34b06262b
ToppCellCOVID-19-lung-Secretory|lung / Disease (COVID-19 only), tissue and cell type

EPS8 SHROOM3 SHANK2 FHOD3 WNK2

1.29e-0518971584d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 PRR15 IRX1

6.08e-051337145bf5e654653e2c340891f51e3f2a30441b7b6b2b
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHANK2 GPR150 TSC22D4 IKZF4

7.02e-051387146b83c434895d82eaf3c222eef27acec76f9c0a77
ToppCellPND07-Immune-Immune_Myeloid-DC-cDC2|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EPS8 WAS SH3BP1 IRF5

9.45e-0514971432e0be7da42d26956683b21a1e7ae6915e4c16fb
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PCED1A PRR15 THAP1 RXRB

1.16e-04157714ffb8dd381e6b9adc5283fb49586e8bd63773c8d6
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PCED1A PRR15 THAP1 RXRB

1.16e-04157714c488ab1d6c6c7e5c2f4426805d1366b44711a031
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GGN DUSP9 SH3BP1 ZNF385C

1.18e-0415871491d265e95156f16459924d3e4dd11c180e164eee
ToppCell390C-Epithelial_cells-Epithelial-H_(AT1)|390C / Donor, Lineage, Cell class and subclass (all cells)

SHANK2 DUSP9 NUTM2D FHOD3

1.24e-04160714830f17bad94de05612fe6d53d39e42a4b3f3e2f3
ToppCell390C-Epithelial_cells-Epithelial-H_(AT1)-|390C / Donor, Lineage, Cell class and subclass (all cells)

SHANK2 DUSP9 NUTM2D FHOD3

1.24e-0416071418ae6822915d16699beb9047baeef9b006901a35
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CARMIL3 FMN2 COL22A1 MARCHF4

1.47e-04167714c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)|Children_(3_yrs) / Lineage, Cell type, age group and donor

FMN2 COL22A1 MARCHF4 WNK2

1.53e-04169714b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCellfacs|World / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2B RBM26 SH3BP1 NSD3

1.60e-04171714c9990bc041a632b2f7bbebbfe737772c423d7027
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT2_Progenitor|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

1.72e-04174714d0e3d15731de6c19c232e3aa492c39d8151cf4ed
ToppCell390C-Lymphocytic-NK_cells-NK_cell_A2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

VPS37C PPP1R37 SMN1 HOMEZ

1.75e-04175714da191dfb8a7f976a632a3a0b923942ab54f5c8c1
ToppCellControl-Epithelial_alveolar-AT_1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

1.87e-04178714aa7d43c655df493f1330a5001efaa484e4a19f69
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-Tuft|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CARMIL3 ZFHX2 ZFHX3 WNK2

1.87e-04178714f17c3b7bb562ac24c6a03fe3c9ba94c2b434c141
ToppCellControl-Epithelial_alveolar-AT_1-AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

1.87e-041787141817bc520f3d23da8c0fa09bba50ae703a820cb1
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

1.91e-0417971404ce3673e46606f63d9c87bcba3a64c96817d812
ToppCell15-Airway-Epithelial-Submucosal_gland|Airway / Age, Tissue, Lineage and Cell class

SHROOM3 SHANK2 IRX1 WNK2

1.95e-04180714283bb0d58811947bfda4e286b9ec87d869c8e29e
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

SHROOM3 SHANK2 ROBO2 WNK2

1.95e-04180714b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCellControl-Epithelial_alveolar-AT_1-AT1-AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

2.04e-04182714a95956ce4adccb34cc0c47ebfa1878ce4617904e
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-AT1-AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

2.04e-04182714cc79e0cc21e2fdc4ef77f052818d27b9f707aec1
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT1-AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

2.08e-0418371406ac66726ec53db810ebb90ec69cfdb903da53f6
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

2.08e-04183714ff6dde877659cde9daa3263db0932c9c9ef1adac
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

2.08e-04183714274483009b309289e4cb84beedf6806430db6ff6
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

2.12e-04184714cdf6f1c6cce97a7effa0c55959652e2c0b6992b3
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-AT2_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

2.12e-041847147cc5796557379c3d1db078c1aeda40659c6e401c
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-AT1-AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

2.17e-041857143bef59cc0aa939d2a7e52f0f6c61bc00528fe50b
ToppCellLPS_only-Epithelial_alveolar-AT_1-AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

2.17e-041857140c247a3f394c42e2a6f67fee3d9cf33096fecd13
ToppCellLPS_only-Epithelial_alveolar-AT_1-AT1-AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

2.17e-0418571468f428e169cfb77de970bdfdeea9b9f16f68d2ba
ToppCellControl-Epithelial_alveolar|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

2.17e-041857143937e026add96a396122139daf8011cfbc60e75c
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

2.17e-04185714c82eab551f65ecebe6db908eda9f9eb3414693c7
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

EPS8 SHROOM3 SHANK2 WNK2

2.17e-04185714cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellLPS_only-Epithelial_alveolar|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

2.21e-04186714e0a2ea4b46af742bc7c9b2072bb85e27d5c92712
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

EPS8 SHROOM3 SHANK2 IRX1

2.21e-04186714e83718fabb057100835d3357df407f283d23fe16
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

2.21e-041867143aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FMN2 COL22A1 MARCHF4 WNK2

2.21e-04186714b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellLPS_only-Epithelial_alveolar-AT_1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

2.26e-04187714ff26a533d310126521efe1d05cf8b9d32e524550
ToppCellLPS-antiTNF-Epithelial_alveolar|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

2.26e-04187714201ff693e4756ee3e44762885b3a303a77eb535b
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

2.31e-0418871443a0508d2524a5b310e89e9422843dcaab999bc3
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_neural-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SBK1 GNAS MARCHF4 WNK2

2.35e-041897148e6b6025f5554672e26a5d19fe365acb4333789c
ToppCell(1)_Osterolineage_cells-(10)_OLC-1|World / Cell class and subclass of bone marrow stroma cells in homeostatis

ZFHX4 ROBO2 FHOD3 COL22A1

2.35e-0418971446c5b975fb9d33017f2d9b7770d45a8bdf95baa2
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-AT2_Progenitor|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHROOM3 SHANK2 ATOH8 IRX1

2.35e-041897145f883ef4cc0383142d538ae61f4fb40dfdb8ef18
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DUSP9 ROBO2 IRX1 GNAS

2.40e-04190714498bbe063bc75d323cb186a82cce122b511d2cff
ToppCell(1)_Osterolineage_cells|World / Cell class and subclass of bone marrow stroma cells in homeostatis

ZFHX4 ROBO2 FHOD3 COL22A1

2.55e-04193714035eeea9f77c4bf9cd85f07fa791b6c857be76b5
ToppCellE15.5-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FBN1 ROBO2 FHOD3 COL22A1

2.55e-04193714e787e618f6e8a1e22be366ce606bf78831b60a90
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CARMIL3 FMN2 KMT2A ROBO2

2.65e-041957143e519cffa6144a62b06124642a14c9ff39b76554
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SHROOM3 SHANK2 PRR15 WNK2

2.65e-04195714e7230a849ea31e6eef9bc6f5468938499450582d
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CARMIL3 FMN2 KMT2A ROBO2

2.65e-041957147796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SHROOM3 SHANK2 ZFHX4 FHOD3

2.70e-04196714c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ZFHX4 ROBO2 FHOD3 COL22A1

2.81e-041987141f956e369e00d37835095a001db4b62a79014532
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ZFHX4 ROBO2 FHOD3 COL22A1

2.81e-04198714dc6fbad0ecdd057189f71afcdb6aca25207314a3
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FMN2 PRR15 THAP1 WNK2

2.81e-04198714dd0465b45b02cb8edf0914d19afb52fcaaeb012c
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SHANK2 FMN2 ROBO2 R3HDM1

2.81e-041987144ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellTracheal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Duct|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SHROOM3 SHANK2 IRX1 WNK2

2.86e-04199714ef1a0c278c23614fd6a3218a9733abe6ecd6f686
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

EPS8 SHROOM3 BRD4 NSD3

2.86e-04199714c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell(05)_Secretory-(2)_GFP_FOXI1|(05)_Secretory / shred by cell type by condition

EPS8 BRD4 RDX GNAS

2.86e-04199714d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SHANK1 FBN1 ZFHX4 ZFHX3

2.86e-04199714abd6117f8a3d7e798d8471c16d97b34aaf50fc9c
ToppCell10x5'v1-week_17-19-Mesenchymal_osteo-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ZFHX4 ROBO2 FHOD3 COL22A1

2.92e-042007143c898e81444b001835c3f1bbc68183078701b135
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Cortical_neuron|10w / Sample Type, Dataset, Time_group, and Cell type.

SBK1 ZFHX4 ROBO2 ZFHX3

2.92e-0420071468c90376e2779434e4ad8dc6dd3b44baa700e2f4
ToppCell10x5'v1-week_17-19-Mesenchymal_osteo|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ZFHX4 ROBO2 FHOD3 COL22A1

2.92e-042007143eca8ffeb41b664fbdbbd70b375c5d953503ab29
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SHROOM3 SHANK2 GNAS WNK2

2.92e-042007147c2d499af60654b7b28f172ac2c914ad49fb74b4
Diseasesyndrome (implicated_via_orthology)

SCAF8 NSD3 SCAF4

9.32e-0618683DOID:225 (implicated_via_orthology)
DiseaseDystonia, Paroxysmal

KMT2B DLAT THAP1

9.32e-0618683C0393588
DiseaseWriter's Cramp

KMT2B THAP1

1.09e-047682C4316810
DiseaseDystonia Disorders

KMT2B THAP1

1.09e-047682C0393593
DiseaseIdiopathic familial dystonia

KMT2B THAP1

1.09e-047682C0393598
DiseaseAdult-Onset Idiopathic Focal Dystonias

KMT2B THAP1

1.09e-047682C0752198
DiseaseAdult-Onset Dystonias

KMT2B THAP1

1.09e-047682C0752197
DiseaseAdult-Onset Idiopathic Torsion Dystonias

KMT2B THAP1

1.09e-047682C0752199
DiseaseAutosomal Dominant Familial Dystonia

KMT2B THAP1

1.09e-047682C0752200
DiseaseChildhood Onset Dystonias

KMT2B THAP1

1.09e-047682C0752202
DiseaseAutosomal Recessive Familial Dystonia

KMT2B THAP1

1.09e-047682C0752201
DiseaseDystonia, Primary

KMT2B THAP1

1.09e-047682C0752203
DiseaseDystonias, Sporadic

KMT2B THAP1

1.09e-047682C0752206
DiseaseDystonia, Secondary

KMT2B THAP1

1.09e-047682C0752205
DiseasePseudodystonia

KMT2B THAP1

1.09e-047682C0752208
DiseaseFamilial Dystonia

KMT2B THAP1

1.09e-047682C0752207
DiseaseFocal Dystonia

KMT2B THAP1

1.09e-047682C0743332
DiseaseCornelia De Lange Syndrome

BRD4 KMT2A

1.45e-048682C0270972
DiseaseLiver Diseases, Parasitic

ROBO2 GNAS

1.86e-049682C0023897
Diseasepulse pressure measurement

SHROOM3 FBN1 ZFHX4 RAPH1 PRPF40B RBM33 FHOD3 ZFHX3 IRF5 NSD3 HOMEZ

3.19e-0413926811EFO_0005763
Diseaseblood urea nitrogen measurement

SHROOM3 CDK12 SCAF8 DUSP9 IRF5 GNAS

6.14e-04452686EFO_0004741
Diseaseinfant expressive language ability

RBM26 ROBO2

6.15e-0416682EFO_0006316
DiseaseDystonia, Limb

KMT2B THAP1

6.96e-0417682C0751093
DiseaseDystonia, Diurnal

KMT2B THAP1

6.96e-0417682C0393610
Diseaserenal system measurement

SHROOM3 SCAF8

9.68e-0420682EFO_0004742
Diseaseobsolete_red blood cell distribution width

SETD1B KMT2B CDK12 BRD4 YLPM1 BRD3 IRX1 TSC22D4 R3HDM1 NSD3

9.90e-0413476810EFO_0005192
DiseaseDystonia

KMT2B DLAT THAP1

1.04e-0386683C0013421
DiseaseIntrahepatic Cholangiocarcinoma

ROBO2 GNAS

1.40e-0324682C0345905
DiseaseExtrahepatic Cholangiocarcinoma

ROBO2 GNAS

1.40e-0324682C3805278
DiseaseCholangiocarcinoma

ROBO2 GNAS

1.64e-0326682C0206698
DiseaseSchizoaffective Disorder

MED15 RBM12

2.04e-0329682C0036337
Diseasecervical cancer (is_implicated_in)

SF3B4 KMT2A

2.18e-0330682DOID:4362 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
PAAPPLGPPLQPPPT

ZNF385C

146

Q66K41
IPTPGQPLPPQPIPT

GNAS

366

P84996
PPATPIVPVVPPTPP

BRD3

221

Q15059
PQTPPLPPLPPIPAL

CDK12

546

Q9NYV4
VVPPQPLQTPPPVPP

BRD4

241

O60885
PLQTPPPVPPQPQPP

BRD4

246

O60885
APTVPPPLPPTPPQP

SH3BP1

616

Q9Y3L3
SQVPGPPQPPLPAPP

R3HDM1

516

Q15032
PPIPVPPPVPTLPPV

RBM12

206

Q9NTZ6
TLPPVPPVPPIPPVP

RBM12

216

Q9NTZ6
LPPPPPILTPPPVNL

RBM26

346

Q5T8P6
PPVNLRPPVPPPGPL

RBM26

356

Q5T8P6
PVTGPPPPLPPLQPS

RBM26

376

Q5T8P6
TQPPVVPQAPPPPPP

RBM33

311

Q96EV2
PPPPPPPQQQPIRSL

RBM33

321

Q96EV2
ILVPPNGVVPPPPPP

RAPH1

701

Q70E73
TQVAPPTPPPPPPIP

RAPH1

756

Q70E73
PPPPPPPVIPPTENE

RDX

471

P35241
LPTPPPPPPPAPQSQ

ATOH8

121

Q96SQ7
PLPQSPPEIPPQGPP

MAGEC3

386

Q8TD91
PPPPPQVRSVTPPPP

LATS1

236

O95835
PPPPQQPPPLPQLGS

IQSEC2

1291

Q5JU85
QPPPLPQLGSIPPPP

IQSEC2

1296

Q5JU85
GLLLPPPPPPPPTQE

CARMIL3

1076

Q8ND23
PQVPPPTPPPVAAVP

DLAT

316

P10515
PTPPPVAAVPPTPQP

DLAT

321

P10515
VPGPLPPPIPGPNPH

PCED1A

381

Q9H1Q7
PGPPLQPPPPAPVLL

DUSP9

66

Q99956
VPTPPPPPVPPTKQQ

MED15

601

Q96RN5
PPVPQEPAPVPSPPR

KMT2B

571

Q9UMN6
VGVVRPAPPPPPPPL

KMT2B

2246

Q9UMN6
PPTLQPPVVLGPPAP

IRF5

181

Q13568
PPGLQELPPLPPPTP

GGN

431

Q86UU5
PPPTPPPTLQPPALQ

GGN

441

Q86UU5
PPPVPGPVTLPPPQL

PELP1

846

Q8IZL8
QPPPEPPRSGPPLPN

PPP1R37

621

O75864
YPPPPLGPIPPVLPV

FBN1

401

P35555
SIPPPPVPGNLLVPP

FHOD3

851

Q2V2M9
TVVTEPPPPPPPQRP

COL22A1

446

Q8NFW1
VVGREPPPVPPPPPL

MARCHF4

96

Q9P2E8
PPPPLLTPPPPLQPA

KMT2A

561

Q03164
PALVIPPQPPTTGPP

KMT2A

1301

Q03164
PPPTPAPVPVPLPPS

EPS8

626

Q12929
TPPLPIPPPPPDIQP

HOMEZ

451

Q8IX15
PPPGTGIPPPPLLPV

FMN2

1226

Q9NZ56
PLPVPVPPIPVPAPI

SCAF4

661

O95104
VPPIPVPAPITVPPP

SCAF4

666

O95104
PGPPPPITPPVSIPP

SCAF4

741

O95104
PVPPPVVPPPTIPPV

SCAF8

696

Q9UPN6
PVPVPVPVPVPVPVP

SBK1

376

Q52WX2
VSLPQGPPPQPPPTI

IKZF4

471

Q9H2S9
VPPPAQPAPGEPTPP

PRR15

31

Q8IV56
PLPPPPPPAAQLPPI

NUTM2D

206

Q5VT03
PLSPPAVPPPPVPVL

RIN1

256

Q13671
PTPQPPTGPPPRLPN

TSC22D4

31

Q9Y3Q8
LPAPPPPQPPVAIAP

IRX1

406

P78414
EPGTEPPPPLPQQPP

FEZF1

436

A0PJY2
PPPPLPQQPPMTLPP

FEZF1

441

A0PJY2
LPPPPPPTSLQPGAP

GPR150

191

Q8NGU9
LPPPPPPPPSQETPV

SHROOM3

1526

Q8TF72
FPSGPPIIPPPPPIC

SMN1

236

Q16637
PAVTVPPPPLPAPPG

SETD1B

721

Q9UPS6
NAGIPAPPPPLPPQP

SETD1B

1576

Q9UPS6
PLPFVPPPAVPSVPP

PRRC1

71

Q96M27
PPPALPPGSQPIPPT

SMARCC2

961

Q8TAQ2
LPQGVPPPSPPGPPL

RXRB

91

P28702
VIPPPAPPPPPGSAQ

SHANK2

1576

Q9UPX8
PAPATPLPPVPPPAV

SHANK1

1596

Q9Y566
PPPPPLPGPLAQPQA

SHANK1

1846

Q9Y566
VPPPVPAPPTPPPQE

C11orf42

251

Q8N5U0
PPPPPPSAPPQVQLP

ZFHX4

2011

Q86UP3
GPPGLPVPQSPPLPP

ZC3H6

506

P61129
PVPQSPPLPPGPPEI

ZC3H6

511

P61129
AVPPPPTPPPPEALG

ZFHX2

1461

Q9C0A1
SVPPDLPPPPQPAPV

SPEN

2426

Q96T58
LQDGVLTPPPPPPPP

WASH2P

296

Q6VEQ5
PQEQLPPPPLPPPVS

THAP1

96

Q9NVV9
LQDGVLTPPPPPPPP

WASHC1

296

A8K0Z3
PLPPVPLGIAPPPPT

WAS

341

P42768
PPPVPPGPTPVPTGL

PRPF40B

201

Q6NWY9
NVPLPPPPVQPLPGT

ROBO2

1071

Q9HCK4
PQPPPPPSVPQTVIP

NSD3

131

Q9BZ95
PPPVPPPPPVALPEA

YLPM1

16

P49750
SVPVTRPPVPIPPPP

YLPM1

1536

P49750
PPPIAPPLVQPSPPV

WASF1

386

Q92558
PQGEVQGLPPPPPPP

WASF1

416

Q92558
PQPTLPPQPVLPPQP

WNK2

946

Q9Y3S1
PPQPVLPPQPTLPPQ

WNK2

951

Q9Y3S1
LPPQPTLPPQPVLPP

WNK2

956

Q9Y3S1
LPSPPLGPTVPPQPP

WNK2

1551

Q9Y3S1
PPPVRPVPQGTPPVV

VPS37C

176

A5D8V6
PVPPPGALPPGIPPA

SF3B4

246

Q15427
PPPPAAQPPPTPQLP

ZFHX3

3211

Q15911