Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	alpha-catenin binding	CDH26 CDH2	2.68e-04	12	41	2	GO:0045294
GeneOntologyMolecularFunction	acetylcholine binding	CHRFAM7A CHRNA7	3.16e-04	13	41	2	GO:0042166
GeneOntologyMolecularFunction	chloride channel regulator activity	CHRFAM7A CHRNA7	4.25e-04	15	41	2	GO:0017081
GeneOntologyMolecularFunction	adenylate cyclase binding	CHRFAM7A CHRNA7	4.85e-04	16	41	2	GO:0008179
GeneOntologyMolecularFunction	acetylcholine-gated monoatomic cation-selective channel activity	CHRFAM7A CHRNA7	5.49e-04	17	41	2	GO:0022848
GeneOntologyMolecularFunction	toxic substance binding	CHRFAM7A CHRNA7	6.16e-04	18	41	2	GO:0015643
GeneOntologyMolecularFunction	acetylcholine receptor activity	CHRFAM7A CHRNA7	1.01e-03	23	41	2	GO:0015464
GeneOntologyMolecularFunction	neurotransmitter receptor activity	GPR158 CHRFAM7A CHRNA7	1.13e-03	100	41	3	GO:0030594
GeneOntologyBiologicalProcess	positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure	CHRFAM7A CHRNA7	4.05e-06	2	42	2	GO:0001988
GeneOntologyBiologicalProcess	baroreceptor response to decreased systemic arterial blood pressure	CHRFAM7A CHRNA7	1.21e-05	3	42	2	GO:0001982
GeneOntologyBiologicalProcess	generation of ovulation cycle rhythm	CHRFAM7A CHRNA7	2.42e-05	4	42	2	GO:0060112
GeneOntologyBiologicalProcess	sensory processing	CHRFAM7A CHRNA7	4.03e-05	5	42	2	GO:0050893
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback	CHRFAM7A CHRNA7	6.04e-05	6	42	2	GO:0001978
GeneOntologyBiologicalProcess	neuron projection arborization	CHRFAM7A CHRNA7 MOV10	6.30e-05	38	42	3	GO:0140058
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by baroreceptor feedback	CHRFAM7A CHRNA7	1.12e-04	8	42	2	GO:0003025
GeneOntologyBiologicalProcess	regulation of synapse organization	DIP2A CDH2 GPR158 CHRFAM7A PTPRS CHRNA7	1.24e-04	387	42	6	GO:0050807
GeneOntologyBiologicalProcess	regulation of synapse structure or activity	DIP2A CDH2 GPR158 CHRFAM7A PTPRS CHRNA7	1.39e-04	395	42	6	GO:0050803
GeneOntologyBiologicalProcess	positive regulation of CoA-transferase activity	CHRFAM7A CHRNA7	1.44e-04	9	42	2	GO:1905920
GeneOntologyBiologicalProcess	response to cold	PLIN1 CHRFAM7A CHRNA7	1.62e-04	52	42	3	GO:0009409
GeneOntologyBiologicalProcess	regulation of CoA-transferase activity	CHRFAM7A CHRNA7	2.20e-04	11	42	2	GO:1905918
GeneOntologyBiologicalProcess	behavioral response to nicotine	CHRFAM7A CHRNA7	2.20e-04	11	42	2	GO:0035095
GeneOntologyBiologicalProcess	regulation of synapse structural plasticity	CHRFAM7A CHRNA7	2.64e-04	12	42	2	GO:0051823
GeneOntologyBiologicalProcess	regulation of synaptic transmission, dopaminergic	CHRFAM7A CHRNA7	3.11e-04	13	42	2	GO:0032225
GeneOntologyBiologicalProcess	dendrite arborization	CHRFAM7A CHRNA7	4.18e-04	15	42	2	GO:0140059
GeneOntologyBiologicalProcess	postsynapse organization	DIP2A CDH2 CHRFAM7A PTPRS CHRNA7	4.18e-04	313	42	5	GO:0099173
GeneOntologyBiologicalProcess	behavioral response to ethanol	CHRFAM7A CHRNA7	5.40e-04	17	42	2	GO:0048149
GeneOntologyBiologicalProcess	regulation of amyloid fibril formation	CHRFAM7A CHRNA7	6.77e-04	19	42	2	GO:1905906
GeneOntologyCellularComponent	spine apparatus membrane	CHRFAM7A CHRNA7	1.12e-05	3	41	2	GO:0098897
GeneOntologyCellularComponent	postsynaptic specialization membrane	CDH2 GPR158 CHRFAM7A PTPRS CHRNA7	4.42e-05	201	41	5	GO:0099634
GeneOntologyCellularComponent	spine apparatus	CHRFAM7A CHRNA7	1.34e-04	9	41	2	GO:0097444
GeneOntologyCellularComponent	presynaptic membrane	CDH2 GPR158 CHRFAM7A PTPRS CHRNA7	2.00e-04	277	41	5	GO:0042734
GeneOntologyCellularComponent	acetylcholine-gated channel complex	CHRFAM7A CHRNA7	5.63e-04	18	41	2	GO:0005892
GeneOntologyCellularComponent	glycinergic synapse	CHRFAM7A CHRNA7	6.97e-04	20	41	2	GO:0098690
GeneOntologyCellularComponent	axolemma	CHRFAM7A CHRNA7	7.70e-04	21	41	2	GO:0030673
GeneOntologyCellularComponent	cholinergic synapse	CHRFAM7A CHRNA7	8.46e-04	22	41	2	GO:0098981
GeneOntologyCellularComponent	postsynaptic membrane	CDH2 GPR158 CHRFAM7A PTPRS CHRNA7	1.12e-03	405	41	5	GO:0045211
GeneOntologyCellularComponent	catenin complex	CDH26 CDH2	1.79e-03	32	41	2	GO:0016342
GeneOntologyCellularComponent	asymmetric synapse	CDH2 GPR158 CHRFAM7A PTPRS CHRNA7	2.31e-03	477	41	5	GO:0032279
GeneOntologyCellularComponent	postsynaptic specialization	CDH2 GPR158 CHRFAM7A PTPRS CHRNA7	2.90e-03	503	41	5	GO:0099572
GeneOntologyCellularComponent	plasma membrane raft	CDH2 CHRFAM7A CHRNA7	2.99e-03	147	41	3	GO:0044853
GeneOntologyCellularComponent	neuron to neuron synapse	CDH2 GPR158 CHRFAM7A PTPRS CHRNA7	3.43e-03	523	41	5	GO:0098984
MousePheno	airway basal cell hyperplasia	CHRFAM7A CHRNA7	5.74e-06	2	34	2	MP:0011115
MousePheno	abnormal airway basal cell differentiation	CHRFAM7A CHRNA7	5.74e-06	2	34	2	MP:0011114
MousePheno	abnormal airway basal cell morphology	CHRFAM7A CHRNA7	5.74e-06	2	34	2	MP:0011113
MousePheno	abnormal nicotine-mediated receptor currents	CHRFAM7A CHRNA7	3.43e-05	4	34	2	MP:0009475
MousePheno	impaired olfaction	CHRFAM7A PTPRS CHRNA7	4.60e-05	29	34	3	MP:0008544
MousePheno	failure of neuromuscular synapse presynaptic differentiation	CHRFAM7A CHRNA7	8.56e-05	6	34	2	MP:0001054
MousePheno	abnormal brain interneuron morphology	LHX6 CHRFAM7A CHRNA7	9.65e-05	37	34	3	MP:0004101
MousePheno	abnormal GABAergic neuron physiology	CHRFAM7A CHRNA7	1.59e-04	8	34	2	MP:0011987
MousePheno	abnormal olfaction	CHRFAM7A PTPRS CHRNA7	2.38e-04	50	34	3	MP:0001984
MousePheno	abnormal olfactory system physiology	CHRFAM7A PTPRS CHRNA7	3.70e-04	58	34	3	MP:0001983
MousePheno	impaired spatial working memory	CHRFAM7A CHRNA7	3.73e-04	12	34	2	MP:0014370
MousePheno	decreased erythroblast number	CHRFAM7A CHRNA7	3.73e-04	12	34	2	MP:0011179
Domain	DMAP_binding	DIP2C DIP2A	4.45e-05	5	40	2	PF06464
Domain	DMAP_binding	DIP2C DIP2A	6.67e-05	6	40	2	SM01137
Domain	DMAP1-bd	DIP2C DIP2A	6.67e-05	6	40	2	IPR010506
Domain	Acetylcholine_rcpt_TM	CHRFAM7A CHRNA7	1.10e-03	23	40	2	IPR027361
Domain	-	CHRFAM7A CHRNA7	1.10e-03	23	40	2	1.20.120.370
Domain	AMP-binding	DIP2C DIP2A	1.87e-03	30	40	2	PF00501
Domain	AMP-dep_Synth/Lig	DIP2C DIP2A	1.87e-03	30	40	2	IPR000873
Domain	Bromodomain	ZMYND11 ATAD2B	2.99e-03	38	40	2	PF00439
Domain	BROMODOMAIN_2	ZMYND11 ATAD2B	3.48e-03	41	40	2	PS50014
Domain	BROMO	ZMYND11 ATAD2B	3.65e-03	42	40	2	SM00297
Domain	Bromodomain	ZMYND11 ATAD2B	3.65e-03	42	40	2	IPR001487
Domain	-	ZMYND11 ATAD2B	3.65e-03	42	40	2	1.20.920.10
Domain	Neurotransmitter_ion_chnl_CS	CHRFAM7A CHRNA7	4.18e-03	45	40	2	IPR018000
Domain	Neur_chan_memb	CHRFAM7A CHRNA7	4.36e-03	46	40	2	PF02932
Domain	Neur_chan_LBD	CHRFAM7A CHRNA7	4.55e-03	47	40	2	PF02931
Domain	Neur_channel	CHRFAM7A CHRNA7	4.55e-03	47	40	2	IPR006201
Domain	Neur_chan_lig-bd	CHRFAM7A CHRNA7	4.55e-03	47	40	2	IPR006202
Domain	NEUROTR_ION_CHANNEL	CHRFAM7A CHRNA7	4.55e-03	47	40	2	PS00236
Domain	Neurotrans-gated_channel_TM	CHRFAM7A CHRNA7	4.55e-03	47	40	2	IPR006029
Domain	-	CHRFAM7A CHRNA7	4.55e-03	47	40	2	2.70.170.10
Pathway	REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING	AGO4 PLIN1 MOV10	1.07e-04	47	28	3	M29777
Pathway	REACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION	AGO4 MOV10	1.36e-04	9	28	2	M27810
Pathway	REACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION	AGO4 MOV10	1.36e-04	9	28	2	M46436
Pathway	REACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS	AGO4 MOV10	1.70e-04	10	28	2	M48013
Pathway	REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS	AGO4 CDH2 MOV10	2.01e-04	58	28	3	M11980
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRFAM7A CHRNA7	2.48e-04	12	28	2	MM15312
Pathway	REACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION	AGO4 MOV10	2.93e-04	13	28	2	M46434
Pathway	REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS	CHRFAM7A CHRNA7	3.93e-04	15	28	2	MM14704
Pathway	REACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY	AGO4 MOV10	5.08e-04	17	28	2	M27788
Pathway	REACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS	AGO4 MOV10	6.37e-04	19	28	2	M48238
Pathway	REACTOME_CELL_CELL_JUNCTION_ORGANIZATION	AGO4 CDH2 MOV10	7.34e-04	90	28	3	M820
Pathway	WP_15Q133_COPY_NUMBER_VARIATION_SYNDROME	CHRFAM7A CHRNA7	9.38e-04	23	28	2	M39883
Pathway	REACTOME_TGFBR3_EXPRESSION	AGO4 MOV10	1.39e-03	28	28	2	M48253
Pathway	REACTOME_CELL_JUNCTION_ORGANIZATION	AGO4 CDH2 MOV10	1.57e-03	117	28	3	M19248
Pathway	KEGG_MEDICUS_REFERENCE_NUCLEAR_EXPORT_OF_MRNA	NCBP1 NUP160	1.60e-03	30	28	2	M47752
Pathway	REACTOME_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION	AGO4 MOV10	1.82e-03	32	28	2	M48012
Pathway	REACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY	AGO4 MOV10	1.82e-03	32	28	2	M27900
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4	AGO4 MOV10	2.05e-03	34	28	2	M46422
Pathway	REACTOME_NUCLEAR_EVENTS_STIMULATED_BY_ALK_SIGNALING_IN_CANCER	AGO4 MOV10	2.17e-03	35	28	2	M42525
Pathway	REACTOME_ONCOGENE_INDUCED_SENESCENCE	AGO4 MOV10	2.17e-03	35	28	2	M27190
Pubmed	The contribution of de novo coding mutations to autism spectrum disorder.	DIP2A SPEN MOV10	1.42e-06	18	43	3	25363768
Pubmed	Activation of nicotinic acetylcholine receptor α7 subunit limits Zika viral infection via promoting autophagy and ferroptosis.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	38822526
Pubmed	Enhancing cognitive function in chronic TBI: The Role of α7 nicotinic acetylcholine receptor modulation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	38070724
Pubmed	Inflammatory cytokines decrease the expression of nicotinic acetylcholine receptor during the cell maturation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	19626424
Pubmed	Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	17012698
Pubmed	Hydroxynorketamine, but not ketamine, acts via α7 nicotinic acetylcholine receptor to control presynaptic function and gene expression.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	38253622
Pubmed	{alpha}7-nAChR-mediated suppression of hyperexcitability of colonic dorsal root ganglia neurons in experimental colitis.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	20595621
Pubmed	Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	26451017
Pubmed	Nicotine stimulates nerve growth factor in lung fibroblasts through an NFκB-dependent mechanism.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	25296021
Pubmed	The role of dorsal root ganglia alpha-7 nicotinic acetylcholine receptor in complete Freund's adjuvant-induced chronic inflammatory pain.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	34514543
Pubmed	Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	34453977
Pubmed	Perinatal hypoxia-ischemia reduces α 7 nicotinic receptor expression and selective α 7 nicotinic receptor stimulation suppresses inflammation and promotes microglial Mox phenotype.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	24757672
Pubmed	Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	26999808
Pubmed	α7 nicotinic acetylcholine receptor (α7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	22183893
Pubmed	Delayed procedural learning in α7-nicotinic acetylcholine receptor knockout mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	21679297
Pubmed	Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	27129924
Pubmed	Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	17291692
Pubmed	Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	23521765
Pubmed	Evidence that alpha7 nicotinic receptor modulates glutamate release from mouse neocortical gliosomes.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	17462791
Pubmed	Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	28258105
Pubmed	alpha7 Nicotinic acetylcholine receptor knockout selectively enhances ethanol-, but not beta-amyloid-induced neurotoxicity.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	15555774
Pubmed	Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	9364063
Pubmed	The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	19344760
Pubmed	Expression of the α7 nAChR Subunit Duplicate Form (CHRFAM7A) Was Down-Regulated in Patients with Intracranial Infection and Reduced Inflammation in in vitro Model by p38 MAPK.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	35100606
Pubmed	Evidence suggesting that the mouse sperm acrosome reaction initiated by the zona pellucida involves an alpha7 nicotinic acetylcholine receptor.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	12606407
Pubmed	ST/b and DBA/2 mice differ in brain alpha-bungarotoxin binding and alpha 7 nicotinic receptor subunit mRNA levels: a quantitative autoradiographic analysis.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	8804729
Pubmed	Loss of α7nAChR enhances endothelial-to-mesenchymal transition after myocardial infarction via NF-κB activation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	35926661
Pubmed	The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	17640819
Pubmed	Genetic variations in CHRNA7 or CHRFAM7 and susceptibility to dementia.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	22300029
Pubmed	The pathophysiology of traumatic brain injury in alpha7 nicotinic cholinergic receptor knockout mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	16545784
Pubmed	Lung epithelial response to cigarette smoke and modulation by the nicotinic alpha 7 receptor.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	29117258
Pubmed	Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	23431157
Pubmed	Deficiency of alpha7 cholinergic receptors facilitates bacterial clearance in Escherichia coli peritonitis.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	18627272
Pubmed	Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	29114104
Pubmed	GTS-21 ameliorates polymicrobial sepsis-induced hepatic injury by modulating autophagy through α7nAchRs in mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	32018068
Pubmed	CHRNA7 and CHRFAM7A mRNAs: co-localized and their expression levels altered in the postmortem dorsolateral prefrontal cortex in major psychiatric disorders.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	26206074
Pubmed	Nicotine elicits prolonged calcium signaling along ventral hippocampal axons.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	24349346
Pubmed	Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	33995108
Pubmed	E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	32552811
Pubmed	The role of nicotinic acetylcholine receptor (nAChR) α7 subtype in the functional interaction between nicotine and ethanol in mouse cerebellum.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	21143250
Pubmed	Wnt/β-catenin signaling plays an essential role in α7 nicotinic receptor-mediated neuroprotection of dopaminergic neurons in a mouse Parkinson's disease model.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	28551099
Pubmed	Cholinergic modulation of appetite-related synapses in mouse lateral hypothalamic slice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	16319313
Pubmed	Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	24836856
Pubmed	Modulation of the MAPKs pathways affects Aβ-induced cognitive deficits in Alzheimer's disease via activation of α7nAChR.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	31904546
Pubmed	Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	16785311
Pubmed	Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	15948184
Pubmed	Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	35678315
Pubmed	Normal apoptosis levels in mice expressing one alpha7 nicotinic receptor null and one L250T mutant allele.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	11409732
Pubmed	Age-Associated Tooth Loss and Oral Microbial Dysbiosis in a Mouse Genetic Model of Chronic Nicotine Exposure.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	33117372
Pubmed	Impaired synaptic plasticity in the visual cortex of mice lacking α7-nicotinic receptor subunit.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	25797465
Pubmed	Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog.	DIP2C DIP2A	1.49e-06	2	43	2	12137943
Pubmed	Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	12628457
Pubmed	Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	25157794
Pubmed	Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	19615981
Pubmed	Combined administration of anisodamine and neostigmine rescued acute lethal crush syndrome through α7nAChR-dependent JAK2-STAT3 signaling.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	27874086
Pubmed	Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-out mice via the spleen-gut-brain axis.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	38944290
Pubmed	Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	29197398
Pubmed	Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	28243714
Pubmed	Cholinergic signaling via the α7 nicotinic acetylcholine receptor regulates the migration of monocyte-derived macrophages during acute inflammation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	38178134
Pubmed	Mesenchymal Stem Cells or Interleukin-6 Improve Episodic Memory of Mice Lacking α7 Nicotinic Acetylcholine Receptors.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	31202708
Pubmed	Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	22246862
Pubmed	alpha7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	17218065
Pubmed	Stimulation of the α7 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	24298024
Pubmed	In hippocampal oriens interneurons anti-Hebbian long-term potentiation requires cholinergic signaling via α7 nicotinic acetylcholine receptors.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	23325242
Pubmed	Lung eosinophilia induced by house dust mites or ovalbumin is modulated by nicotinic receptor α7 and inhibited by cigarette smoke.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	29975102
Pubmed	Capped small RNAs and MOV10 in human hepatitis delta virus replication.	AGO4 MOV10	1.49e-06	2	43	2	18552826
Pubmed	α7-nAChR Knockout Mice Decreases Biliary Hyperplasia and Liver Fibrosis in Cholestatic Bile Duct-Ligated Mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	29580318
Pubmed	Glutamatergic synapse formation is promoted by α7-containing nicotinic acetylcholine receptors.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	22649244
Pubmed	Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	35479080
Pubmed	Olfactory discrimination varies in mice with different levels of α7-nicotinic acetylcholine receptor expression.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	20713028
Pubmed	Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	17898229
Pubmed	Antimuscle atrophy effect of nicotine targets muscle satellite cells partly through an α7 nicotinic receptor in a murine hindlimb ischemia model.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	24811002
Pubmed	[Activation of α7 nAChR improves white fat homeostasis and promotes beige adipogenesis and thermogenesis in obese mice].	CHRFAM7A CHRNA7	1.49e-06	2	43	2	38597441
Pubmed	Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	21901321
Pubmed	Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	27471776
Pubmed	Dopamine release in prefrontal cortex in response to beta-amyloid activation of alpha7 * nicotinic receptors.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	17935702
Pubmed	Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	22688057
Pubmed	Cortical parvalbumin GABAergic deficits with α7 nicotinic acetylcholine receptor deletion: implications for schizophrenia.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	24983521
Pubmed	α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	22820264
Pubmed	Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	33953172
Pubmed	Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	32028688
Pubmed	Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	20624304
Pubmed	Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	21784975
Pubmed	Genetic variation in CHRNA7 and CHRFAM7A is associated with nicotine dependence and response to varenicline treatment.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	30089821
Pubmed	Nicotinic acetylcholine receptor activation reduces skeletal muscle inflammation of mdx mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	20615555
Pubmed	Nicotine physical dependence in the mouse: involvement of the alpha7 nicotinic receptor subtype.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	15896732
Pubmed	Lack of acetylcholine nicotine alpha 7 receptor suppresses development of collagen-induced arthritis and adaptive immunity.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	20659128
Pubmed	Stimulation of α7 nicotinic acetylcholine receptor by nicotine increases suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	20843956
Pubmed	Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	10800961
Pubmed	Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	30429582
Pubmed	A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	21501254
Pubmed	T-cell receptor activation decreases excitability of cortical interneurons by inhibiting α7 nicotinic receptors.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	24381265
Pubmed	α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	21339364
Pubmed	Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	21368056
Pubmed	Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	24289814
Pubmed	Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	19949071
Pubmed	Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	1400473
Pubmed	Characterization of allelic variants at chromosome 15q14 in schizophrenia.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	16417613
Pubmed	Dynamic Impairment of Olfactory Behavior and Signaling Mediated by an Olfactory Corticofugal System.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	32817250
Pubmed	Reversible inhibition of GABAA receptors by alpha7-containing nicotinic receptors on the vertebrate postsynaptic neurons.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	17204496
Cytoband	9q33.2	OR1K1 LHX6	6.21e-04	39	43	2	9q33.2
Cytoband	3p21.3	DLEC1 SLC22A14	1.42e-03	59	43	2	3p21.3
Cytoband	Ensembl 112 genes in cytogenetic band chr10p15	DIP2C ZMYND11	3.26e-03	90	43	2	chr10p15
Cytoband	Ensembl 112 genes in cytogenetic band chr15q13	CHRFAM7A CHRNA7	4.00e-03	100	43	2	chr15q13
Cytoband	1q21.3	SCNM1 CRTC2	5.43e-03	117	43	2	1q21.3
Coexpression	GSE2124_CTRL_VS_LYMPHOTOXIN_BETA_TREATED_MLN_UP	TGM6 SSTR3 ERN2 RPS6KL1 GZMM	1.37e-05	197	41	5	M6191
Disease	X-13548 measurement	DIP2C ZMYND11	1.79e-06	2	40	2	EFO_0021353
Disease	cognitive disorder (implicated_via_orthology)	CHRFAM7A CHRNA7	2.68e-05	6	40	2	DOID:1561 (implicated_via_orthology)
Disease	rheumatoid arthritis (biomarker_via_orthology)	CHRFAM7A CHRNA7	2.68e-05	6	40	2	DOID:7148 (biomarker_via_orthology)
Disease	nicotine dependence (implicated_via_orthology)	CHRFAM7A CHRNA7	1.17e-04	12	40	2	DOID:0050742 (implicated_via_orthology)
Disease	hepatocellular carcinoma	DLEC1 TM6SF2	1.42e-03	41	40	2	EFO_0000182
Disease	liver fat measurement	TM6SF2 SPEN	1.56e-03	43	40	2	EFO_0010821
Disease	esophagus squamous cell carcinoma (is_implicated_in)	SPEN CHRNA7	1.71e-03	45	40	2	DOID:3748 (is_implicated_in)
Disease	irritable bowel syndrome symptom measurement	CHRFAM7A CHRNA7	2.82e-03	58	40	2	EFO_0021536
Disease	ankle injury	DIP2C DLEC1	2.92e-03	59	40	2	EFO_1002021
Disease	t-tau:beta-amyloid 1-42 ratio measurement	DIP2A TBC1D22A	3.64e-03	66	40	2	EFO_0007708
Disease	Petit mal status	SSTR3 CDH2	3.75e-03	67	40	2	C0270823
Disease	Status Epilepticus, Subclinical	SSTR3 CDH2	3.75e-03	67	40	2	C0751522
Disease	Simple Partial Status Epilepticus	SSTR3 CDH2	3.75e-03	67	40	2	C0751524
Disease	Non-Convulsive Status Epilepticus	SSTR3 CDH2	3.75e-03	67	40	2	C0751523
Disease	Grand Mal Status Epilepticus	SSTR3 CDH2	3.75e-03	67	40	2	C0311335
Disease	Complex Partial Status Epilepticus	SSTR3 CDH2	3.75e-03	67	40	2	C0393734
Disease	Status Epilepticus	SSTR3 CDH2	3.86e-03	68	40	2	C0038220
Disease	schizophrenia (implicated_via_orthology)	CHRFAM7A CHRNA7	3.86e-03	68	40	2	DOID:5419 (implicated_via_orthology)
Disease	feeling miserable measurement	NUP160 ATAD2B	5.17e-03	79	40	2	EFO_0009598
Disease	Nerve Degeneration	CDH2 CHRNA7	5.69e-03	83	40	2	C0027746
Disease	hormone measurement	CDH2 ATAD2B	5.82e-03	84	40	2	EFO_0004730
Disease	orofacial cleft, sex interaction measurement	CHRFAM7A CHRNA7	6.09e-03	86	40	2	EFO_0008343, MONDO_0000358
Disease	depressive symptom measurement, response to antidepressant	DIP2C GZMM	6.37e-03	88	40	2	EFO_0007006, GO_0036276

Protein segments in the cluster

Peptide	Gene	Start	Entry
EVIPHSRPYMASLQR	GZMM	31	P51124
TRHLPSMRYTPVGRS	AGO4	156	Q9HCK5
PYPDVTFTVTMRRRT	CHRNA7	216	P36544
PYHRRPVLRAEFTQM	AOC2	161	O75106
HTEDSVYPMPRVIFR	NCBP1	276	Q09161
TPVRYRVRDMTVPTA	LIPM	336	Q5VYY2
RTVPSAFHEPRYMAV	GPR158	601	Q5T848
REARRTVPSIVYMPH	ATAD2B	821	Q9ULI0
RTQYTVTMHDPRAPA	ERN2	161	Q76MJ5
IHYTPFSSPERARMV	LHX6	301	Q9UPM6
FRSAPVYMPTVVLRR	IL17D	131	Q8TAD2
PYPDVTFTVTMRRRT	CHRFAM7A	126	Q494W8
AIRHPLPYATRMSRA	OR1K1	126	Q8NGR3
RRVAPRFSILPMSHE	PTPRS	241	Q13332
FRPSVMEPILGRTHY	PLIN1	501	O60240
PHASTREYVMFRTPL	FBXO5	311	Q9UKT4
PRRMVSPLRRYTRHI	CRTC2	111	Q53ET0
PVTPRYMRHFNIITI	DNAH7	2101	Q8WXX0
GMRYHPIDIETSVIR	DIP2C	1451	Q9Y2E4
IYVHRPVDREMTPSF	CDH26	116	Q8IXH8
PTRMLFVTPRRQHES	KANSL3	56	Q9P2N6
GMRYHPIDIETSVIR	DIP2A	1466	Q14689
DYLRVARGPMPVHTT	FAM90A20P	141	A6NIJ5
TTEIPHYFRLMVSRP	DLEC1	1511	Q9Y238
FRHVVPSIMEVPARL	SLC22A14	411	Q9Y267
PMSPTRRRALDHYLT	SCNM1	181	Q9BWG6
IRRMDERPIHAEPQY	CDH2	806	P19022
PLRHSMVLTYTVVGR	OR52M1	131	Q8NGK5
VMSVDRYLAVVHPTR	SSTR3	136	P32745
AMRHIVTGTTRPAPY	MOV10	506	Q9HCE1
LPHPSRMYRSELVVD	NUP160	166	Q12769
YRVRVEDIMVRDVPH	CLCN2	576	P51788
LHPYTVPRDVRIMVH	SPEN	3186	Q96T58
PYDIPHRARMISLIE	RIPK2	256	O43353
PATAVIIYRMRTHPI	SMIM3	41	Q9BZL3
VFLRVASRPMPVHTT	FAM90A2P	141	Q658T7
SRERLTIIPHGVPYM	RPS6KL1	186	Q9Y6S9
TYRQIHIDIPRMSPE	TBC1D22A	276	Q8WUA7
PMYRRLVHSAVDVPT	ZMYND11	186	Q15326
VQEMRVGSHIPYRRI	SNAPC4	361	Q5SXM2
ASMHLRTPFTYRVPE	TM6SF2	316	Q9BZW4
VEQRRGSPMEPVHYV	VWA7	341	Q9Y334
RHNPIYVTRVISAMV	TGM6	211	O95932
HMPTIRVPRSGDRVY	USP13	31	Q92995