Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	group III metabotropic glutamate receptor activity	GRM6 GRM7 GRM8	2.38e-07	4	79	3	GO:0001642
GeneOntologyMolecularFunction	glutamate receptor activity	GRIN3A GRM6 GRM7 GRM8	3.72e-06	27	79	4	GO:0008066
GeneOntologyMolecularFunction	G protein-coupled glutamate receptor activity	GRM6 GRM7 GRM8	4.92e-06	9	79	3	GO:0098988
GeneOntologyMolecularFunction	cyclic nucleotide-dependent protein kinase activity	PRKG1 PRKX PRKY	4.92e-06	9	79	3	GO:0004690
GeneOntologyMolecularFunction	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	GRM6 GRM7 GRM8	4.92e-06	9	79	3	GO:0001640
GeneOntologyMolecularFunction	glycerol kinase activity	GK GK2	4.62e-05	3	79	2	GO:0004370
GeneOntologyMolecularFunction	procollagen glucosyltransferase activity	PLOD3 PLOD2	4.62e-05	3	79	2	GO:0033823
GeneOntologyMolecularFunction	procollagen-lysine 5-dioxygenase activity	PLOD3 PLOD2	4.62e-05	3	79	2	GO:0008475
GeneOntologyMolecularFunction	peptidyl-lysine 5-dioxygenase activity	PLOD3 PLOD2	9.23e-05	4	79	2	GO:0070815
GeneOntologyMolecularFunction	oxidoreductase activity	PLOD3 BCO2 CHDH CYP4F12 KDM7A ALDH1L1 LBR HSD17B4 COIL PLOD2 SOD2	2.06e-04	766	79	11	GO:0016491
GeneOntologyMolecularFunction	cAMP-dependent protein kinase activity	PRKX PRKY	3.20e-04	7	79	2	GO:0004691
GeneOntologyMolecularFunction	N-acylsphingosine amidohydrolase activity	ASAH2 ASAH2B	3.20e-04	7	79	2	GO:0017040
GeneOntologyMolecularFunction	dioxygenase activity	PLOD3 BCO2 KDM7A PLOD2	6.18e-04	98	79	4	GO:0051213
GeneOntologyMolecularFunction	carbohydrate binding	MRC1 PLOD3 GALNT11 ENPP2 LY75 PLOD2	1.43e-03	310	79	6	GO:0030246
GeneOntologyMolecularFunction	calcium channel activity	TPCN2 TRPM2 GRIN3A GRM7	1.72e-03	129	79	4	GO:0005262
GeneOntologyBiologicalProcess	glutamate receptor signaling pathway	CLN3 GRIN3A GRM6 GRM7 GRM8	2.90e-06	59	78	5	GO:0007215
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	GRM6 GRM7 GRM8	4.30e-06	9	78	3	GO:0007196
GeneOntologyBiologicalProcess	hydroxylysine biosynthetic process	PLOD3 PLOD2	1.41e-05	2	78	2	GO:0046947
GeneOntologyBiologicalProcess	hydroxylysine metabolic process	PLOD3 PLOD2	1.41e-05	2	78	2	GO:0046946
GeneOntologyBiologicalProcess	G protein-coupled glutamate receptor signaling pathway	GRM6 GRM7 GRM8	2.81e-05	16	78	3	GO:0007216
GeneOntologyBiologicalProcess	glycerol-3-phosphate biosynthetic process	GK GK2	4.23e-05	3	78	2	GO:0046167
GeneOntologyBiologicalProcess	lipid catabolic process	BCO2 ASAH2 ENPP2 APOB CYP4F12 HSD17B4 ASAH2B PLCE1	9.74e-05	382	78	8	GO:0016042
GeneOntologyBiologicalProcess	polyol metabolic process	GK GK2 ASAH2 PRKG1 ASAH2B	1.04e-04	123	78	5	GO:0019751
GeneOntologyBiologicalProcess	synaptic transmission, glutamatergic	CLN3 GRIN3A GRM6 GRM7 GRM8	1.44e-04	132	78	5	GO:0035249
GeneOntologyBiologicalProcess	alcohol metabolic process	LDLRAP1 GK GK2 ASAH2 APOB PRKG1 LBR ASAH2B	1.64e-04	412	78	8	GO:0006066
GeneOntologyBiologicalProcess	glycerol catabolic process	GK GK2	2.10e-04	6	78	2	GO:0019563
GeneOntologyBiologicalProcess	cellular catabolic process	TPCN2 BCO2 WDR6 ASAH2 ENPP2 CLN3 ATG4C ZFYVE26 APOB CYP4F12 ALDH1L1 STAM HSD17B4 ASAH2B	2.28e-04	1253	78	14	GO:0044248
GeneOntologyBiologicalProcess	alditol catabolic process	GK GK2	2.93e-04	7	78	2	GO:0019405
GeneOntologyBiologicalProcess	alcohol biosynthetic process	ASAH2 APOB PRKG1 LBR ASAH2B	2.96e-04	154	78	5	GO:0046165
GeneOntologyBiologicalProcess	regulation of synaptic transmission, glutamatergic	CLN3 GRM6 GRM7 GRM8	4.11e-04	92	78	4	GO:0051966
HumanPheno	Coronary artery aneurysm	LDLRAP1 APOB PRKG1	3.18e-06	7	24	3	HP:0030882
Domain	GPCR_3_mtglu_rcpt	GRM6 GRM7 GRM8	3.72e-06	8	77	3	IPR000162
Domain	Ceramidse_alk_C	ASAH2 ASAH2B	1.68e-05	2	77	2	PF17048
Domain	NEUT/ALK_ceramidase_C	ASAH2 ASAH2B	1.68e-05	2	77	2	IPR031331
Domain	Ceramidase_alk	ASAH2 ASAH2B	1.68e-05	2	77	2	IPR006823
Domain	NCD3G	GRM6 GRM7 GRM8	1.87e-05	13	77	3	PF07562
Domain	GPCR_3_9-Cys_dom	GRM6 GRM7 GRM8	1.87e-05	13	77	3	IPR011500
Domain	Peripla_BP_I	GRIN3A GRM6 GRM7 GRM8	1.97e-05	39	77	4	IPR028082
Domain	GPCR_3_CS	GRM6 GRM7 GRM8	2.37e-05	14	77	3	IPR017979
Domain	Nucleotide-diphossugar_trans	GLT8D1 PLOD3 GALNT11 GMPPA PLOD2	3.13e-05	88	77	5	IPR029044
Domain	LYS_HYDROXYLASE	PLOD3 PLOD2	5.02e-05	3	77	2	PS01325
Domain	Carb_kinase_FGGY_CS	GK GK2	5.02e-05	3	77	2	IPR018483
Domain	Procol_lys_dOase	PLOD3 PLOD2	5.02e-05	3	77	2	IPR001006
Domain	GPCR_3	GRM6 GRM7 GRM8	8.49e-05	21	77	3	IPR000337
Domain	7tm_3	GRM6 GRM7 GRM8	9.81e-05	22	77	3	PF00003
Domain	G_PROTEIN_RECEP_F3_2	GRM6 GRM7 GRM8	9.81e-05	22	77	3	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GRM6 GRM7 GRM8	9.81e-05	22	77	3	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GRM6 GRM7 GRM8	9.81e-05	22	77	3	PS00979
Domain	G_PROTEIN_RECEP_F3_4	GRM6 GRM7 GRM8	9.81e-05	22	77	3	PS50259
Domain	GPCR_3_C	GRM6 GRM7 GRM8	9.81e-05	22	77	3	IPR017978
Domain	TM_Fragile-X-F-assoc	TMEM185B TMEM185A	1.00e-04	4	77	2	IPR019396
Domain	Tmemb_185A	TMEM185B TMEM185A	1.00e-04	4	77	2	PF10269
Domain	Glycerol_kin	GK GK2	1.00e-04	4	77	2	IPR005999
Domain	FGGY_KINASES_2	GK GK2	1.66e-04	5	77	2	PS00445
Domain	FGGY_KINASES_1	GK GK2	1.66e-04	5	77	2	PS00933
Domain	Carb_kinase_FGGY_C	GK GK2	1.66e-04	5	77	2	IPR018485
Domain	RICIN	MRC1 GALNT11 LY75	2.05e-04	28	77	3	SM00458
Domain	RICIN_B_LECTIN	MRC1 GALNT11 LY75	2.05e-04	28	77	3	PS50231
Domain	BRK	CHD9 CHD6	2.49e-04	6	77	2	SM00592
Domain	FGGY_C	GK GK2	2.49e-04	6	77	2	PF02782
Domain	Carb_kinase_FGGY_N	GK GK2	2.49e-04	6	77	2	IPR018484
Domain	BRK_domain	CHD9 CHD6	2.49e-04	6	77	2	IPR006576
Domain	BRK	CHD9 CHD6	2.49e-04	6	77	2	PF07533
Domain	Ricin_B_lectin	MRC1 GALNT11 LY75	2.52e-04	30	77	3	IPR000772
Domain	Carb_kinase_FGGY	GK GK2	3.48e-04	7	77	2	IPR000577
Domain	FGGY_N	GK GK2	3.48e-04	7	77	2	PF00370
Domain	-	GLT8D1 GALNT11 GMPPA PLOD2	3.49e-04	81	77	4	3.90.550.10
Domain	ANF_lig-bd_rcpt	GRM6 GRM7 GRM8	4.73e-04	37	77	3	IPR001828
Domain	ANF_receptor	GRM6 GRM7 GRM8	4.73e-04	37	77	3	PF01094
Domain	Quinoprotein_ADH-like_supfam	WDR6 EML6 STAM	1.36e-03	53	77	3	IPR011047
Domain	FN_type2_col-bd	MRC1 LY75	1.48e-03	14	77	2	IPR000562
Domain	FN2_2	MRC1 LY75	1.48e-03	14	77	2	PS51092
Domain	fn2	MRC1 LY75	1.48e-03	14	77	2	PF00040
Domain	FN2_1	MRC1 LY75	1.48e-03	14	77	2	PS00023
Domain	FN2	MRC1 LY75	1.48e-03	14	77	2	SM00059
Domain	AGC-kinase_C	RPS6KA4 PRKG1 PRKX	1.60e-03	56	77	3	IPR000961
Domain	AGC_KINASE_CTER	RPS6KA4 PRKG1 PRKX	1.60e-03	56	77	3	PS51285
Domain	S_TK_X	RPS6KA4 PRKG1 PRKX	1.60e-03	56	77	3	SM00133
Domain	P4Hc	PLOD3 PLOD2	1.94e-03	16	77	2	SM00702
Domain	Pro_4_hyd_alph	PLOD3 PLOD2	1.94e-03	16	77	2	IPR006620
Domain	2OG-FeII_Oxy	PLOD3 PLOD2	2.74e-03	19	77	2	PF03171
Domain	RCC1	HERC2 RCC2	3.04e-03	20	77	2	PF00415
Domain	RCC1_1	HERC2 RCC2	3.35e-03	21	77	2	PS00625
Domain	RCC1_2	HERC2 RCC2	3.35e-03	21	77	2	PS00626
Domain	RCC1_3	HERC2 RCC2	3.35e-03	21	77	2	PS50012
Domain	FE2OG_OXY	PLOD3 PLOD2	3.35e-03	21	77	2	PS51471
Domain	Reg_chr_condens	HERC2 RCC2	3.67e-03	22	77	2	IPR000408
Domain	-	HERC2 RCC2	3.67e-03	22	77	2	2.130.10.30
Domain	Oxoglu/Fe-dep_dioxygenase	PLOD3 PLOD2	4.01e-03	23	77	2	IPR005123
Domain	RCC1/BLIP-II	HERC2 RCC2	4.01e-03	23	77	2	IPR009091
Pathway	WP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES	LDLRAP1 MRC1 ENPP2 CLN3 RABGAP1L TMPRSS5 APOB LBR HSD17B4 LY75	3.56e-06	381	59	10	M48063
Pathway	WP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE	GRM6 GRM7 GRM8	3.06e-05	15	59	3	M39442
Pathway	WP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE	GRM6 GRM7 GRM8	3.06e-05	15	59	3	MM15845
Pathway	REACTOME_CHYLOMICRON_CLEARANCE	LDLRAP1 APOB	1.71e-04	5	59	2	M27845
Pathway	REACTOME_CHYLOMICRON_CLEARANCE	LDLRAP1 APOB	1.71e-04	5	59	2	MM15564
Pubmed	Distribution of group-III metabotropic glutamate receptors in the retina.	GRM6 GRM7 GRM8	4.68e-08	4	80	3	17311335
Pubmed	Pias1 interaction and sumoylation of metabotropic glutamate receptor 8.	GRM6 GRM7 GRM8	2.33e-07	6	80	3	16144832
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIN3A GRM6 GRM7 GRM8	2.66e-07	24	80	4	35746896
Pubmed	Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.	GRM6 GRM7 GRM8	1.39e-06	10	80	3	9069281
Pubmed	Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites.	CLN3 TNFAIP6 HSD17B4	2.54e-06	12	80	3	11375929
Pubmed	Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.	ASAH2 ASAH2B	5.23e-06	2	80	2	10652340
Pubmed	Neutral ceramidase gene: role in regulating ceramide-induced apoptosis.	ASAH2 ASAH2B	5.23e-06	2	80	2	14557071
Pubmed	The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability.	PRKX PRKY	5.23e-06	2	80	2	7633447
Pubmed	Genomic structure and promoter analysis of the mouse neutral ceramidase gene.	ASAH2 ASAH2B	5.23e-06	2	80	2	12435403
Pubmed	Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney.	ASAH2 ASAH2B	5.23e-06	2	80	2	11328816
Pubmed	Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection.	ASAH2 ASAH2B	5.23e-06	2	80	2	35354041
Pubmed	Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu.	ASAH2 ASAH2B	5.23e-06	2	80	2	16126722
Pubmed	Complete genomic structure of mouse lysyl hydroxylase 2 and lysyl hydroxylase 3/collagen glucosyltransferase.	PLOD3 PLOD2	5.23e-06	2	80	2	11334715
Pubmed	Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation.	ASAH2 ASAH2B	5.23e-06	2	80	2	19345744
Pubmed	Lactosylceramide contributes to mitochondrial dysfunction in diabetes.	ASAH2 ASAH2B	5.23e-06	2	80	2	26900161
Pubmed	A novel gene, FAM11A, associated with the FRAXF CpG island is transcriptionally silent in FRAXF full mutation.	TMEM185B TMEM185A	5.23e-06	2	80	2	12404111
Pubmed	Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus.	GRM7 GRM8	5.23e-06	2	80	2	23220400
Pubmed	Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.	ASAH2 ASAH2B	5.23e-06	2	80	2	22940715
Pubmed	Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.	ASAH2 ASAH2B	5.23e-06	2	80	2	24659784
Pubmed	A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease.	ASAH2 ASAH2B	5.23e-06	2	80	2	17334805
Pubmed	Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death.	ASAH2 ASAH2B	5.23e-06	2	80	2	26747710
Pubmed	No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals.	GRM7 GRM8	5.23e-06	2	80	2	11912074
Pubmed	Significant association of GRM7 and GRM8 genes with schizophrenia and major depressive disorder in the Han Chinese population.	GRM7 GRM8	5.23e-06	2	80	2	26655190
Pubmed	Man to mouse--lessons learned from the distal end of the human X chromosome.	PRKX PRKY	5.23e-06	2	80	2	9414316
Pubmed	Profiles of PrKX expression in developmental mouse embryo and human tissues.	PRKX PRKY	5.23e-06	2	80	2	15879576
Pubmed	Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA.	ASAH2 ASAH2B	5.23e-06	2	80	2	21613224
Pubmed	Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases.	ASAH2 ASAH2B	5.23e-06	2	80	2	10753931
Pubmed	Differential roles of mGlu(7) and mGlu(8) in amygdala-dependent behavior and physiology.	GRM7 GRM8	5.23e-06	2	80	2	23664812
Pubmed	Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids.	ASAH2 ASAH2B	5.23e-06	2	80	2	16380386
Pubmed	PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation.	PRKX PRKY	5.23e-06	2	80	2	21684272
Pubmed	Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.	PRKX PRKY	5.23e-06	2	80	2	9302280
Pubmed	Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury.	ASAH2 ASAH2B	5.23e-06	2	80	2	35151662
Pubmed	Identification of genetic drivers of plasma lipoprotein size in the Diversity Outbred mouse population.	ASAH2 ASAH2B	5.23e-06	2	80	2	37944753
Pubmed	Glycerol kinase 2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis.	GK GK2	5.23e-06	2	80	2	30662012
Pubmed	A novel murine PKA-related protein kinase involved in neuronal differentiation.	PRKX PRKY	5.23e-06	2	80	2	10729225
Pubmed	Role of neutral ceramidase in colon cancer.	ASAH2 ASAH2B	5.23e-06	2	80	2	27609772
Pubmed	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	GRIN3A GRM6 GRM7 GRM8 SOD2	8.10e-06	118	80	5	19156168
Pubmed	The molecular circuitry regulating the switch between iron deficiency and overload in mice.	ASAH2 ASAH2B	1.57e-05	3	80	2	16418170
Pubmed	Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages.	ASAH2 ASAH2B	1.57e-05	3	80	2	38302493
Pubmed	Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency.	PRKX PRKY	1.57e-05	3	80	2	17980165
Pubmed	Glycerol kinase-like proteins cooperate with Pld6 in regulating sperm mitochondrial sheath formation and male fertility.	GK GK2	1.57e-05	3	80	2	28852571
Pubmed	Trpm2 deficiency in microglia attenuates neuroinflammation during epileptogenesis by upregulating autophagy via the AMPK/mTOR pathway.	TRPM2 ALDH1L1	1.57e-05	3	80	2	37648036
Pubmed	FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12-->q13.	PRKX PRKY	1.57e-05	3	80	2	9154127
Pubmed	Characterization of cDNAs for mouse lysyl hydroxylase 1, 2 and 3, their phylogenetic analysis and tissue-specific expression in the mouse.	PLOD3 PLOD2	1.57e-05	3	80	2	10429951
Pubmed	Identification of amino acids important for the catalytic activity of the collagen glucosyltransferase associated with the multifunctional lysyl hydroxylase 3 (LH3).	PLOD3 PLOD2	1.57e-05	3	80	2	11896059
Pubmed	Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3. The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activity.	PLOD3 PLOD2	1.57e-05	3	80	2	11956192
Pubmed	Lysyl hydroxylase 3 is a multifunctional protein possessing collagen glucosyltransferase activity.	PLOD3 PLOD2	1.57e-05	3	80	2	10934207
Pubmed	Identification of a functional hepatocyte nuclear factor 4 binding site in the neutral ceramidase promoter.	ASAH2 ASAH2B	1.57e-05	3	80	2	20803549
Pubmed	Procollagen-lysine, 2-oxoglutarate 5-dioxygenases 1, 2, and 3 are potential prognostic indicators in patients with clear cell renal cell carcinoma.	PLOD3 PLOD2	1.57e-05	3	80	2	31446433
Pubmed	Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.	GRM7 GRM8	1.57e-05	3	80	2	33068816
Pubmed	Expression of intestinal and lung alkaline sphingomyelinase and neutral ceramidase in cystic fibrosis f508del transgenic mice.	ASAH2 ASAH2B	1.57e-05	3	80	2	18955860
Pubmed	Neutral ceramidase secreted by endothelial cells is released in part associated with caveolin-1.	ASAH2 ASAH2B	1.57e-05	3	80	2	12921776
Pubmed	Primary structure, tissue distribution, and chromosomal localization of a novel isoform of lysyl hydroxylase (lysyl hydroxylase 3).	PLOD3 PLOD2	1.57e-05	3	80	2	9582318
Pubmed	CuZn-SOD deficiency causes ApoB degradation and induces hepatic lipid accumulation by impaired lipoprotein secretion in mice.	APOB SOD2	1.57e-05	3	80	2	16921198
Pubmed	The lysyl hydroxylase isoforms are widely expressed during mouse embryogenesis, but obtain tissue- and cell-specific patterns in the adult.	PLOD3 PLOD2	1.57e-05	3	80	2	16996725
Pubmed	Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells.	GRM7 GRM8	1.57e-05	3	80	2	9473604
Pubmed	The genes encoding mouse lysyl hydroxylase isoforms map to chromosomes 4,5, and 9.	PLOD3 PLOD2	1.57e-05	3	80	2	11130984
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	GK GK2 ASAH2 MTG2 CHDH MRPL3 ALDH1L1 HSD17B4 SLC25A25 ASAH2B SOD2	2.74e-05	1047	80	11	18614015
Pubmed	Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes.	PLOD3 PLOD2	3.13e-05	4	80	2	16467571
Pubmed	PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43.	PLOD3 PLOD2	3.13e-05	4	80	2	33483598
Pubmed	Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis.	ASAH2 ASAH2B	3.13e-05	4	80	2	33547170
Pubmed	Effects of familial hypercholesterolemia-associated genes on the phenotype of premature myocardial infarction.	LDLRAP1 APOB	3.13e-05	4	80	2	30971288
Pubmed	Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder.	GRM7 GRM8	3.13e-05	4	80	2	17167337
Pubmed	CD44 binds to macrophage mannose receptor on lymphatic endothelium and supports lymphocyte migration via afferent lymphatics.	MRC1 LY75	3.13e-05	4	80	2	23603511
Pubmed	Localization of neutral ceramidase in caveolin-enriched light membranes of murine endothelial cells.	ASAH2 ASAH2B	3.13e-05	4	80	2	11591392
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	GRIN3A GRM6 GRM7 GRM8	3.77e-05	81	80	4	22723691
Pubmed	Identification of host proteins required for HIV infection through a functional genomic screen.	ARHGAP32 PLOD3 CLN3 KEL KDM7A PRKX	4.01e-05	272	80	6	18187620
Pubmed	Genotype patterns that contribute to increased risk for or protection from developing heroin addiction.	GRM6 GRM8	5.20e-05	5	80	2	18195715
Pubmed	The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons.	GK GK2	5.20e-05	5	80	2	7987308
Pubmed	Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif.	GRAP2 STAM	5.20e-05	5	80	2	17235283
Pubmed	Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor.	TMEM185B TMEM185A	5.20e-05	5	80	2	15525354
Pubmed	Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase.	RPS6KA4 PRKG1	7.79e-05	6	80	2	8688081
Pubmed	Genome-wide association study of personality traits in bipolar patients.	GRM7 PLCE1	7.79e-05	6	80	2	21368711
Pubmed	Response to methadone maintenance treatment is associated with the MYOCD and GRM6 genes.	GRM6 GRM8	7.79e-05	6	80	2	20560679
Pubmed	NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation.	RPS6KA4 PRKG1	7.79e-05	6	80	2	11175347
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	SUGP2 CHD9 ZFYVE26 HERC2	1.00e-04	104	80	4	9205841
Pubmed	AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4.	GRAP2 STAM	1.09e-04	7	80	2	20159979
Pubmed	Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion.	GRM6 GRM7	1.09e-04	7	80	2	9920659
Pubmed	Genetically Confirmed Familial Hypercholesterolemia in Patients With Acute Coronary Syndrome.	LDLRAP1 APOB	1.09e-04	7	80	2	28958330
Pubmed	Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice.	PLOD3 PLOD2	1.09e-04	7	80	2	15377789
Pubmed	Retrotransposition of glycerol kinase-related genes from the X chromosome to autosomes: functional and evolutionary aspects.	GK GK2	1.09e-04	7	80	2	10444329
Pubmed	Familial Hypercholesterolemia	LDLRAP1 APOB	1.45e-04	8	80	2	24404629
Pubmed	Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.	PRKX PRKY	1.45e-04	8	80	2	22641646
Pubmed	CREB is a regulatory target for the protein kinase Akt/PKB.	RPS6KA4 PRKG1	1.45e-04	8	80	2	9829964
Pubmed	Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.	GRM6 GRM7 GRM8	1.55e-04	45	80	3	25979088
Pubmed	The repertoire of olfactory C family G protein-coupled receptors in zebrafish: candidate chemosensory receptors for amino acids.	GRM7 GRM8	2.32e-04	10	80	2	17156446
Pubmed	Divergent phenotypes in constitutive versus conditional mutant mouse models of Sifrim-Hitz-Weiss syndrome.	EOMES ALDH1L1	2.32e-04	10	80	2	37738575
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	GK2 ASAH2 MTG2 CHDH MRPL3 ALDH1L1 HSD17B4 SLC25A25 SOD2	2.77e-04	926	80	9	20877624
Pubmed	Brain-specific Pd1 deficiency leads to cortical neurogenesis defects and depressive-like behaviors in mice.	EOMES ALDH1L1	2.84e-04	11	80	2	37553426
Pubmed	Transient microglial absence assists postmigratory cortical neurons in proper differentiation.	EOMES MRC1	2.84e-04	11	80	2	32242005
Pubmed	RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.	SUGP2 WDR6 LBR COIL	3.87e-04	148	80	4	35676246
Pubmed	LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis.	EOMES ENPP2	4.01e-04	13	80	2	33510165
Pubmed	Neocortical neuronal production and maturation defects in the TcMAC21 mouse model of Down syndrome.	EOMES ALDH1L1	4.01e-04	13	80	2	38025769
Pubmed	Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.	PRKG1 GRM8 TMPRSS11B	4.02e-04	62	80	3	17975119
Pubmed	Gene variants associated with ischemic stroke: the cardiovascular health study.	PRKG1 GRM8 TMPRSS11B	4.21e-04	63	80	3	19023099
Pubmed	Dentate gyrus development requires a cortical hem-derived astrocytic scaffold.	EOMES ALDH1L1	4.67e-04	14	80	2	33393905
Pubmed	Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.	RPS6KA4 PRKG1	4.67e-04	14	80	2	9687510
Pubmed	Comparison of the Spatiotemporal Expression Patterns of Three Cre Lines, Emx1IRES-Cre, D6-Cre and hGFAP-Cre, Commonly Used in Neocortical Development Research.	EOMES ALDH1L1	4.67e-04	14	80	2	34550336
Pubmed	Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus.	TMPRSS5 PRKG1	5.38e-04	15	80	2	25338677
Pubmed	A conserved molecular logic for neurogenesis to gliogenesis switch in the cerebral cortex.	EOMES ALDH1L1	6.14e-04	16	80	2	38713624
GeneFamily	Glutamate metabotropic receptors\|Protein phosphatase 1 regulatory subunits	GRM6 GRM7 GRM8	9.14e-07	8	47	3	281
GeneFamily	Glycerol kinases	GK GK2	9.86e-05	6	47	2	568
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	MRC1 LY75	2.23e-03	27	47	2	1253
ToppCell	droplet-Kidney-nan-18m-Epithelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GK GALNT11 ENPP2 SLC47A1 APOB ALDH1L1 SOD2	4.31e-08	187	79	7	236e9857729670e87eed30fad58f49e1f56e4a85
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Ndrg2_(MyelinProcesses)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TMPRSS5 APOB TNFAIP6 TEX52 OCSTAMP	2.63e-07	77	79	5	4720aa099bd00d05b721634eedc9a08b0213ee67
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Ndrg2_(MyelinProcesses)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TMPRSS5 APOB TNFAIP6 TEX52 OCSTAMP	2.63e-07	77	79	5	25a8dd4cdba4d96d6b0c35fa6310bfff6ce64265
ToppCell	LPS_only-Myeloid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GK TRPM2 MYO1F GPR141 TNFAIP6 SOD2	8.78e-07	182	79	6	666ac86ee5f6fa9241ae8d80340743707e54b278
ToppCell	LPS-IL1RA-Myeloid\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GK TRPM2 MYO1F GPR141 TNFAIP6 SOD2	9.65e-07	185	79	6	9b5fd87ea9d05e051ff1251578ecfbe5e8652853
ToppCell	LPS-antiTNF-Myeloid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GK TRPM2 MYO1F GPR141 TNFAIP6 SOD2	9.96e-07	186	79	6	839c6da5244f469461b2e5563e36162b2911cd01
ToppCell	LPS-IL1RA+antiTNF-Myeloid\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GK TRPM2 MYO1F GPR141 TNFAIP6 SOD2	1.03e-06	187	79	6	4e0bbef6ba0d1b3e1f8d900d4a9dbd41f09a7bc5
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O1-Trf\|Thalamus / BrainAtlas - Mouse McCarroll V32	ENPP2 CHDH TMPRSS5 TNFAIP6 TEX52	1.70e-06	112	79	5	cb351e57c99aaaf9ae6c7ff7e8ce5375552b1639
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)\|Thalamus / BrainAtlas - Mouse McCarroll V32	ENPP2 CHDH TMPRSS5 TNFAIP6 TEX52	1.70e-06	112	79	5	999b5eeed4305e1a1385aadbaf017b64f21c1ee0
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	ENPP2 CHDH TMPRSS5 TNFAIP6 TEX52	1.70e-06	112	79	5	004cd69b66c3b26b9a61f03279b48230da351574
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O1\|Thalamus / BrainAtlas - Mouse McCarroll V32	ENPP2 CHDH TMPRSS5 TNFAIP6 TEX52	1.70e-06	112	79	5	502e3f356f6e1c959bff0a39c98f33f863ce8265
ToppCell	E16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 TPCN2 BCO2 MYO1F ZFYVE26	1.00e-05	161	79	5	5a8698790f9aba796dd2b64af419055c60bd7de8
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BCL2L14 BCO2 LY75 OCSTAMP PLCE1	1.27e-05	169	79	5	9c9bb1b32fc6e22359424a262178906c3954415d
ToppCell	LPS_only-Myeloid-Neutrophils\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GK TRPM2 MYO1F TNFAIP6 SOD2	1.67e-05	179	79	5	d0a03e498afcfeb657037889685ecd77bed07e6c
ToppCell	LPS_only-Myeloid-Neutrophils-Neutrophils\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GK TRPM2 MYO1F TNFAIP6 SOD2	1.67e-05	179	79	5	d034651a5a355a58f5e15db627869f4feebdfe35
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GK GALNT11 ENPP2 SLC47A1 APOB	1.91e-05	184	79	5	c86ed59fed687cdaaf7e9c4418d2e3e2c4111cca
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GK GALNT11 ENPP2 SLC47A1 APOB	1.91e-05	184	79	5	7c256bcfa07c5ff55aad0833e8712b0456b5832b
ToppCell	Striatum-Macroglia-OLIGODENDROCYTE\|Striatum / BrainAtlas - Mouse McCarroll V32	CHDH TMPRSS5 TEX52 OCSTAMP	1.92e-05	89	79	4	ee1dd3571f5914a8274b71f9ca8b36132ae87fe1
ToppCell	droplet-Kidney-nan-3m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GK GALNT11 ENPP2 SLC47A1 APOB	1.96e-05	185	79	5	3e3217c99719fd1d2fa94e16be7712a7e5077152
ToppCell	droplet-Kidney-nan-3m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GK GALNT11 ENPP2 SLC47A1 APOB	1.96e-05	185	79	5	0ff4148b4701003d9d594e0da8261176fb13aa59
ToppCell	Control-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	FZD4 GVINP1 ITGA10 PRKG1 GRM8	2.12e-05	188	79	5	88b3415e33db81726dd29c1f50c886e057af50a0
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MRC1 GK TRPM2 GRAP2 MYO1F	2.17e-05	189	79	5	7ccea2df93bb4b37417bbc8f6c85a61ece95211a
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC47A1 GRIN3A PLOD2 PRKX PLCE1	2.23e-05	190	79	5	d19bc44310c53726e2f5f6a2bd377bbbf1d1983f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MRC1 GK TRPM2 GRAP2 MYO1F	2.29e-05	191	79	5	468b5149d1533f03521844d3cce8633d44eb6ed4
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	EOMES BCO2 MYO1F GPR141 PRKG1	2.34e-05	192	79	5	df4741e7684f010445f0224a1fd61aaa4fae02b3
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_9\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BCL2L14 ENPP2 MRPL3 PRKG1 LY75	2.40e-05	193	79	5	89c63dd5d97fbd92ea308405b7e8e630dda5158d
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_9\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	BCL2L14 ENPP2 MRPL3 PRKG1 LY75	2.40e-05	193	79	5	7842f29c16fe3a289ed3861fa570430142d2363f
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Classical_Monocyte\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GK MYO1F TNFAIP6 LBR SOD2	2.59e-05	196	79	5	d9b5eaca4089d5337f1175a663418c9c675cdd87
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GK MYO1F TNFAIP6 LBR SOD2	2.65e-05	197	79	5	037f5f26fa66818baa35846aa96336155e8a6f45
ToppCell	Posterior_cortex-Macroglia-OLIGODENDROCYTE-O2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CHDH TMPRSS5 TNFAIP6 TEX52	2.69e-05	97	79	4	7b17dc28454949a23701ab127300a29a8899d7d6
ToppCell	Posterior_cortex-Macroglia-OLIGODENDROCYTE-O2-Tfr\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CHDH TMPRSS5 TNFAIP6 TEX52	2.69e-05	97	79	4	4b74b3c5b9590a8215b7370b37e9723e9f040b9c
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Mesenchymal-Mesoderm\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	LDLRAP1 APOB PRKG1	4.55e-05	39	79	3	3479d255b87fa8042c51d80a3eb81a774850132e
ToppCell	Substantia_nigra-Macroglia-OLIGODENDROCYTE\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ENPP2 TMPRSS5 TNFAIP6 TEX52	4.57e-05	111	79	4	4a22732094a9781867d501d9c05ba652c2f25048
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ENPP2 CHDH TNFAIP6 TEX52	5.80e-05	118	79	4	d0dd5c882cd9e0a5eb0cb08e47877292126bd4ae
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O1-Trf\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ENPP2 CHDH TNFAIP6 TEX52	5.80e-05	118	79	4	4283699cb3ca7a112faa07727dfdc0b0a67fb779
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O2\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ENPP2 CHDH TNFAIP6 TEX52	6.61e-05	122	79	4	d4152c45dfbb979ddf8380b4896db753a79cad9e
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O2-Trf\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ENPP2 CHDH TNFAIP6 TEX52	6.61e-05	122	79	4	40f983623c990203df4ba997e296231489d51012
ToppCell	Posterior_cortex-Macroglia-OLIGODENDROCYTE\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CHDH TMPRSS5 TNFAIP6 TEX52	7.04e-05	124	79	4	9f169fa17be1842a6bd83778ff30465a740edd5f
ToppCell	LPS-antiTNF-Myeloid-Dendritic_cells-Monocytes-Macrophages\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MRC1 DNASE2B GPR141 SLC47A1	7.96e-05	128	79	4	cfc73cb803ba50a4a8709e19e70e1e399118c849
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Neuron\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	EOMES EML6 SRPK3 PRKX	8.20e-05	129	79	4	64768adf23123b92280fb30eb85147cbee084ae0
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ENPP2 CHDH TNFAIP6 TEX52	8.20e-05	129	79	4	98a5f24de72d2ae6a57787226b2e523ddd13b2c5
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE-O2-Trf\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CHDH TMPRSS5 TNFAIP6 TEX52	8.97e-05	132	79	4	dc6edfa821a1cdc645668b0af5ba5ff80dee10bd
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE-O2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CHDH TMPRSS5 TNFAIP6 TEX52	8.97e-05	132	79	4	60ced08bda5efc95a6f116cd0c6d1a779d99ed38
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CHDH TMPRSS5 TNFAIP6 TEX52	1.04e-04	137	79	4	5e97480f014f1d9267e8126f1d0e58acd22f36aa
ToppCell	droplet-Heart-nan-3m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRAP2 KEL LY75 OCSTAMP	1.13e-04	140	79	4	ab90f6f30d89761687f8836e3d327d143ce49ed4
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRPM2 MYO1F GPR141 KDM7A	1.29e-04	145	79	4	ab0e254a8d01021619853a6c175f620ccef217d8
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic-Neutrophil\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRPM2 MYO1F GPR141 KDM7A	1.29e-04	145	79	4	2beb4ea3838796c580076ab7769de877a3a0552c
ToppCell	E18.5-Immune-Immune_Myeloid-Granulocytic\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNASE2B TRPM2 MYO1F GRM6	1.43e-04	149	79	4	5a5e9660f7d9b527f50a92d94d4c0c8aedb82c0b
ToppCell	Frontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnf.Ptgds_(Ptgds)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CHDH TNFAIP6 TEX52	1.50e-04	58	79	3	92afa343d2e80ea076533ab2e45f63a4638f37aa
ToppCell	Frontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnf.Ptgds_(Ptgds)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CHDH TNFAIP6 TEX52	1.50e-04	58	79	3	f840029b1fcca7570aa836eded41dc33ca5aa0a6
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL2L14 MYO1F GPR141 LY75	1.88e-04	160	79	4	8dae9b0cf90a09acb196223f45a14680102630b2
ToppCell	facs-MAT-Fat-18m-Myeloid-myeloid_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GK TRPM2 MYO1F GPR141	1.88e-04	160	79	4	bd5fa7959bfe81011b8d798535b73ea1eee008b3
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|368C / Donor, Lineage, Cell class and subclass (all cells)	MRC1 DNASE2B MYO1F LY75	1.88e-04	160	79	4	ac3f56f8ab8efd11c4b4868a828db05c23ac762f
ToppCell	Frontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnf.Kif5b_(Kif5b)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CHDH TNFAIP6 TEX52	1.92e-04	63	79	3	50ea93ea08d8e7a1a2508e8a2c569f6f5dc91961
ToppCell	Frontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnf.Kif5b_(Kif5b)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CHDH TNFAIP6 TEX52	1.92e-04	63	79	3	c30197502348f07ded57ad4e50862e61e2fba51e
ToppCell	facs-Pancreas-Exocrine-18m-Hematologic-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EOMES GRAP2 MYO1F GPR141	1.93e-04	161	79	4	16f77e7a5444d2f2b210362816cd7a07b9b42af6
ToppCell	facs-Pancreas-Exocrine-18m-Hematologic\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EOMES GRAP2 MYO1F GPR141	1.93e-04	161	79	4	f5821f551cf5c64c9f75cdb723492c87aac1ece0
ToppCell	droplet-Heart-nan-24m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCL2L14 MYO1F LY75 OCSTAMP	1.93e-04	161	79	4	7e60001637ef0f6fc67ef8a36ab80ebb25b0b0ab
ToppCell	facs-Pancreas-Exocrine-18m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EOMES GRAP2 MYO1F GPR141	1.93e-04	161	79	4	58a32a1033f379579697bda1bbf047a088e4a34f
ToppCell	droplet-Mammary_Gland-nan-18m-Myeloid-macrophage\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 TRPM2 GRM8 OCSTAMP	1.97e-04	162	79	4	59147406c28b7cdf43a1815f99c15c2bd6ae8fa3
ToppCell	droplet-Mammary_Gland-nan-18m-Myeloid\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 TRPM2 GRM8 OCSTAMP	1.97e-04	162	79	4	8e0bcc23c3086fc4b0c9dbeec13a7edaf6b83750
ToppCell	droplet-Mammary_Gland-nan-18m-Myeloid-macrophage\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 TRPM2 GRM8 OCSTAMP	1.97e-04	162	79	4	736fdcbd0f7d50fc297f13d36ab4c0dc82ad509c
ToppCell	droplet-Lung-nan-18m-Myeloid-intermediate_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLOD3 MYO1F GPR141 KDM7A	2.12e-04	165	79	4	e32697321cef424c2ad4e11ee9da3e510d5ce505
ToppCell	droplet-Lung-21m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 ALDH1L1 COIL GMPPA	2.12e-04	165	79	4	354978d4f35154d7b2e36e94de669e045adef512
ToppCell	droplet-Lung-nan-18m-Myeloid-Intermediate_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLOD3 MYO1F GPR141 KDM7A	2.12e-04	165	79	4	0fbdd043e11aa8dbff4cd3a4da1b2feb49878a09
ToppCell	droplet-Lung-LUNG-1m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP32 CHDH RABGAP1L GRM8	2.16e-04	166	79	4	6e6075d0c913e2516083f6dcab21d5878bcef7a4
ToppCell	facs-Lung-nan-3m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BCO2 GPR141 ATG4C KDM7A	2.16e-04	166	79	4	5c132f505dc5f699c87913f140344fc9f8e7e0f5
ToppCell	PND01-03-samps-Myeloid\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	MRC1 CLN3 MYO1F GPR141	2.16e-04	166	79	4	99dc8a186ec12d3563e81fa4618a814740332c73
ToppCell	droplet-Lung-1m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGAP32 CHDH RABGAP1L GRM8	2.16e-04	166	79	4	1ca888ae8168707493f19ee52a89d7c70e6cb51d
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP32 CHDH RABGAP1L GRM8	2.16e-04	166	79	4	4fbe44e0aea197893614cd55f83119aa0f73ee53
ToppCell	droplet-Lung-1m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGAP32 CHDH RABGAP1L GRM8	2.16e-04	166	79	4	4cba4ca1aa2321b9ef7cd230932b890d2434a252
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KY GRAP2 GPR141 KEL	2.21e-04	167	79	4	a813b95c2fafb638b249bc4fa4f708c6f39ad444
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC2\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RPS6KA4 BCO2 GRAP2 MYO1F	2.27e-04	168	79	4	93b7138f17aa14a6398c9b4ea7237781a0e19a66
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MRC1 GK TRPM2 MYO1F	2.27e-04	168	79	4	61a5435b27b01ff1a509ea463a6af220c5d2c9b3
ToppCell	droplet-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GK GALNT11 ENPP2 SLC47A1	2.27e-04	168	79	4	dd48da83c32d41a62f80cd7e5e5c64e42776fa27
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Lymphocytic-T_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EOMES WDR6 LY75 GRM6	2.27e-04	168	79	4	182f08106ac65ea501e2fb9139d3b44b7c4662c9
ToppCell	E18.5-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RPS6KA4 BCO2 GRAP2 MYO1F	2.27e-04	168	79	4	e393553208617a023f1646169c892a87c95db3f5
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MRC1 GK TRPM2 MYO1F	2.27e-04	168	79	4	26fce414439ccd204e3acb41f2b4f75072df5a26
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	FZD4 GRAP2 PLOD2 KIAA1614	2.27e-04	168	79	4	b94b1f37c92e019d01ecfa3b7cc6797b6e4a56ff
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARHGAP32 BCO2 GVINP1 TRPM2	2.27e-04	168	79	4	27cdf5cfa1d906868cfd60fdfab3cd51f3b3602f
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Adcyap1_(Dentate_hilum?)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GRAP2 SLC47A1 KEL	2.30e-04	67	79	3	52f6c244e8d89ccacb79bc5ef3663a5d01fd393c
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Adcyap1_(Dentate_hilum?)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	GRAP2 SLC47A1 KEL	2.30e-04	67	79	3	e462f9b5dca7c64101a31891f25654c05f2d215d
ToppCell	343B-Myeloid-Dendritic-cDC_activated\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	BCL2L14 EML6 GPR141 LY75	2.32e-04	169	79	4	e68e6c24606fd46eca6f86bb63fa86ea17879ae2
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage\|390C / Donor, Lineage, Cell class and subclass (all cells)	MRC1 DNASE2B GK ZFYVE26	2.37e-04	170	79	4	3a7121d045f9ae54583b0f5f7436abf3665a1bce
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE-O1-Trf\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TMPRSS5 TNFAIP6 TEX52	2.41e-04	68	79	3	31f9f6b4473970473f89b67643bb55dc332732d8
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TMPRSS5 TNFAIP6 TEX52	2.41e-04	68	79	3	91a500a68245a8a484a537aad2cc8b62ff4579f0
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TMPRSS5 TNFAIP6 TEX52	2.41e-04	68	79	3	a89cc6fb62f50ea4124b1a6b0b30cd7ceb52e408
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE-O1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TMPRSS5 TNFAIP6 TEX52	2.41e-04	68	79	3	3d148bb49246c3fac9a1e864ecc5e15b29863c52
ToppCell	droplet-Spleen-nan-18m-Myeloid-macrophage_dendritic_cell_progenitor\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGAP32 CHDH GRM8 PLOD2	2.42e-04	171	79	4	4e856441063e9825b6f87a1d3dd19c77dae4662c
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D122\|Adult / Lineage, Cell type, age group and donor	FZD4 ITGA10 PRKG1 GRM8	2.42e-04	171	79	4	bd20e85d36fa9d7ddc8afef6a1dea75efc9ee1dc
ToppCell	10x5'-Liver-Myeloid_Mac-Intermediate_macrophages\|Liver / Manually curated celltypes from each tissue	BCL2L14 GK TNFAIP6 SOD2	2.42e-04	171	79	4	25e0333743affdb662223fb5220b8a61fa02ad9f
ToppCell	droplet-Lung-nan-18m-Myeloid-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLOD3 MYO1F GPR141 KDM7A	2.48e-04	172	79	4	35d09640d5b04fa0bbb1b40d4b8f97da587a5046
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MRC1 GK TRPM2 MYO1F	2.48e-04	172	79	4	72fbfa890995e47048b47199c170cc7dcd7661f8
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MRC1 GK TRPM2 MYO1F	2.48e-04	172	79	4	2ca6f0d1181aabe0d0e3e8f2e193f08dbda42dea
ToppCell	droplet-Lung-nan-18m-Myeloid-Classical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLOD3 MYO1F GPR141 KDM7A	2.48e-04	172	79	4	98cb64e2a768908105701a7a5b58f336036250fd
ToppCell	droplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGAP32 CHDH RABGAP1L GRM8	2.53e-04	173	79	4	4f0c065e876197ad8cae7856669f09e37ecafa3f
ToppCell	wk_15-18-Hematologic-Myeloid-Eosinophil\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	GRAP2 GPR141 KEL STAM	2.53e-04	173	79	4	a85cead231e03945fabbc7762540ad21fe4299df
ToppCell	droplet-Lung-30m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGAP32 CHDH RABGAP1L GRM8	2.53e-04	173	79	4	9bbea566964281f47bf75d665b7d69ba8326e207
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 CLN3 LY75 OCSTAMP	2.70e-04	176	79	4	450c25ec5eeb65425f904e0a25aaafdf5682ef9c
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-CX3CR1+_CD8_Tmem\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EOMES MYO1F GPR141 PRKX	2.70e-04	176	79	4	6b06da40eb97ea2db09f3a769494738b3e5fe3fa
Drug	RS)-2-chloro-5-hydroxyphenylglycine	COIL GRM6 GRM7 GRM8	1.29e-06	24	78	4	CID003645780
Drug	cis-MCG-I	GRM6 GRM7 GRM8	2.14e-06	8	78	3	CID003035584
Drug	AC1N21PP	GRM6 GRM7 GRM8	3.20e-06	9	78	3	CID004014619
Drug	1,3-cyclopentanedicarboxylic acid	GRM6 GRM7 GRM8	3.20e-06	9	78	3	CID000107216
Drug	mM PEP	GRM6 GRM7 GRM8	3.20e-06	9	78	3	CID005311462
Drug	NS-105	GRM6 GRM7 GRM8	4.56e-06	10	78	3	CID000198695
Drug	cyclobutylene AP5	GRM6 GRM7 GRM8	6.26e-06	11	78	3	CID000126582
Drug	AMN082	GRM6 GRM7 GRM8	8.32e-06	12	78	3	CID001894360
Drug	AC1NSKBB	GRM6 GRM7 GRM8	1.08e-05	13	78	3	CID005311256
Drug	Mspg	GRM6 GRM7 GRM8	1.08e-05	13	78	3	CID003964410
Drug	MSOPPE	GRM6 GRM7 GRM8	1.08e-05	13	78	3	CID005311463
Drug	IRFI005	KEL APOB	1.16e-05	2	78	2	CID000132223
Drug	2-methyl-6-styrylpyridine	GRM6 GRM7 GRM8	1.37e-05	14	78	3	CID000235382
Drug	MTPG	GRM6 GRM7 GRM8	1.37e-05	14	78	3	CID005311456
Drug	3-(1H-pyrrole-2-carboxylate	TRPM2 PRKG1 GRM6 GRM7 GRM8 RCC2 SPSB2	1.53e-05	233	78	7	CID000005114
Drug	ethylglutamate	GRM6 GRM7 GRM8	2.10e-05	16	78	3	CID000014241
Drug	2-PMPA	GRM6 GRM7 GRM8	2.10e-05	16	78	3	CID010130754
Drug	3HPG	GRM6 GRM7 GRM8	2.54e-05	17	78	3	CID000001217
Drug	acromelic acid A	GRM6 GRM7 GRM8	3.04e-05	18	78	3	CID000108086
Drug	ketamine	GRIN3A LBR STAM HSD17B4 GRM6 GRM7 GRM8	3.25e-05	262	78	7	CID000003821
Drug	1-amino-2-phosphonomethylcyclopropanecarboxylic acid	GRM6 GRM8	3.47e-05	3	78	2	ctd:C523415
Drug	aminocyclopentane	GRM6 GRM7 GRM8	3.60e-05	19	78	3	CID000002906
Drug	2-phenylglycine	GRAP2 GRM6 GRM7 GRM8	3.81e-05	55	78	4	CID000003866
Drug	galactosylhydroxylysine	PLOD3 HSD17B4 PLOD2	4.23e-05	20	78	3	CID000123986
Drug	4-carboxy-3-hydroxyphenylglycine	GRM6 GRM7 GRM8	4.23e-05	20	78	3	CID000001297
Drug	3,4-dihydroxyphenylglycine	GRM6 GRM7 GRM8	4.92e-05	21	78	3	CID000027915
Drug	gentamicin	GK2 KEL APOB PRKG1 SOD2 PLCE1	6.12e-05	198	78	6	CID000003467
Drug	MSOP	GRM6 GRM7 GRM8	6.52e-05	23	78	3	CID003964633
Drug	gadobenate dimeglumine	KY LBR	6.92e-05	4	78	2	CID006918204
Drug	thiourea	KEL GRM6 GRM7 GRM8 SOD2	7.89e-05	128	78	5	CID002723790
Drug	AC1NQH9B	GRM6 GRM7 GRM8	9.50e-05	26	78	3	CID005221504
Drug	felbamate	GRIN3A GRM6 GRM7 GRM8	9.84e-05	70	78	4	CID000003331
Drug	LY393675	GRM6 GRM8	1.15e-04	5	78	2	CID005311262
Drug	NSC291853	HSD17B4 SOD2	1.15e-04	5	78	2	CID005358946
Drug	DMeOB	GRM6 GRM8	1.15e-04	5	78	2	CID002061047
Drug	phanoside	GK GK2	1.15e-04	5	78	2	CID006918773
Drug	tyrphostin B52	GRM6 GRM8	1.15e-04	5	78	2	CID005328773
Drug	dehydro-histidinohydroxymerodesmosine	PLOD3 PLOD2	1.15e-04	5	78	2	CID003037599
Drug	carbachol	TPCN2 RPS6KA4 TRPM2 PRKG1 LBR GRM6 GRM7 GRM8 SOD2 PLCE1	1.17e-04	688	78	10	CID000002551
Drug	C-PP	GRM6 GRM8 SOD2	1.19e-04	28	78	3	CID000001228
Drug	caffeine	TPCN2 ENPP2 CYP4F12 GRM6 GRM7 GRM8 RCC2 SOD2 PLCE1	1.28e-04	562	78	9	CID000002519
Drug	PBDA	GRM6 GRM7 GRM8	1.47e-04	30	78	3	CID000004408
Drug	2-butenedioate	ARHGAP32 CLN3 GRM6 GRM7 GRM8 SOD2	1.53e-04	234	78	6	CID000000723
Drug	AC1MBZ3L	GRM6 GRM8	1.72e-04	6	78	2	CID002733524
Drug	MTEP	GRM6 GRM8	1.72e-04	6	78	2	CID009794218
Drug	pyridinium formate	PLOD3 PLOD2	1.72e-04	6	78	2	CID013326228
Drug	NSC343256	ENPP2 HSD17B4	1.72e-04	6	78	2	CID000335091
Drug	AC1L6XCD	ENPP2 HSD17B4	1.72e-04	6	78	2	CID000325952
Drug	SIB-1757	GRM6 GRM8	1.72e-04	6	78	2	CID006304902
Drug	betaine aldehyde	GK GK2 CHDH	1.79e-04	32	78	3	CID000000249
Drug	alpha-methyl-4-carboxyphenylglycine	GRM6 GRM7 GRM8	1.79e-04	32	78	3	CID000001222
Drug	cADPR	TRPM2 HSD17B4 COIL GRM6	1.82e-04	82	78	4	CID000123847
Drug	1-aminoindan-1,5-dicarboxylic acid	GRM6 GRM7 GRM8	1.96e-04	33	78	3	CID000002071
Drug	CPPG	GRM6 GRM7 GRM8	2.14e-04	34	78	3	CID000002878
Drug	memantine	GRIN3A GRM6 GRM7 GRM8	2.19e-04	86	78	4	CID000004054
Drug	1m5d	GRM6 GRM7 GRM8	2.34e-04	35	78	3	CID000447082
Drug	MPTP-HCl	CLN3 GRM6 GRM7 GRM8 SOD2	2.38e-04	162	78	5	CID000001388
Drug	CDPPB	GRM6 GRM8	2.41e-04	7	78	2	CID011245456
Drug	etofylline	APOB STAM	2.41e-04	7	78	2	CID000001892
Drug	azetidine-2,4-dicarboxylic acid	GRM6 GRM8	2.41e-04	7	78	2	CID000005370
Drug	Carotenoids	BCO2 SOD2	2.41e-04	7	78	2	ctd:D002338
Drug	MCCG-I	GRM6 GRM8	2.41e-04	7	78	2	CID005311457
Drug	Creatinine	SLC47A1 SOD2	2.41e-04	7	78	2	ctd:D003404
Drug	R,S)-AMPA	LBR GRM6 GRM8	2.55e-04	36	78	3	CID000001221
Drug	4-AP	CLN3 PRKG1 GRM6 GRM7 GRM8 SOD2	2.59e-04	258	78	6	CID000001727
Drug	HA1 100	KY GRM6 GRM7 GRM8	2.60e-04	90	78	4	CID003064778
Drug	aurintricarboxylic acid	DNASE2B GRM6 GRM7 GRM8	2.72e-04	91	78	4	CID000002259
Drug	benzyloxyaspartate	GRM6 GRM7 GRM8	2.76e-04	37	78	3	CID004133412
Disease	glycerol kinase deficiency (implicated_via_orthology)	GK GK2	1.96e-05	3	76	2	DOID:0060363 (implicated_via_orthology)
Disease	blood urea nitrogen measurement	BCL2L14 TPCN2 JRK CHD9 LY75 PRKX KIAA1614 PLCE1	2.16e-05	452	76	8	EFO_0004741
Disease	gastric adenocarcinoma	JRK CHD6	3.92e-05	4	76	2	EFO_0000503
Disease	CHARGE syndrome (implicated_via_orthology)	CHD9 CHD6	1.36e-04	7	76	2	DOID:0050834 (implicated_via_orthology)
Disease	familial hyperlipidemia	SUGP2 ATG4C APOB ASAH2B	1.65e-04	106	76	4	MONDO_0001336
Disease	Familial hypercholesterolemia	LDLRAP1 APOB	1.81e-04	8	76	2	cv:C0020445
Disease	neutral ceramidase measurement	ASAH2 PRKG1	2.33e-04	9	76	2	EFO_0008247
Disease	DNA methylation	GK2 SUGP2 RABGAP1L SCART1 TMPRSS5 HSD17B4 GRM8 PLCE1	2.85e-04	656	76	8	GO_0006306
Disease	Astigmatism	EML6 CHD6 HERC2 GRM7	3.51e-04	129	76	4	HP_0000483
Disease	pigmentation disease (is_implicated_in)	TPCN2 HERC2	3.55e-04	11	76	2	DOID:10123 (is_implicated_in)
Disease	interferon alpha measurement	TMPRSS5 PRKG1	4.25e-04	12	76	2	EFO_0006517
Disease	Zellweger Spectrum	PEX10 HSD17B4	5.01e-04	13	76	2	C3658299
Disease	Zellweger-Like Syndrome	PEX10 HSD17B4	5.01e-04	13	76	2	C0751594
Disease	Adrenoleukodystrophy, Neonatal	PEX10 HSD17B4	6.73e-04	15	76	2	C0282525
Disease	squamous cell carcinoma	TPCN2 HERC2 RCC2	6.99e-04	67	76	3	EFO_0000707
Disease	Zellweger Syndrome	PEX10 HSD17B4	7.67e-04	16	76	2	C0043459
Disease	Liver Cirrhosis, Experimental	MTMR7 GK GLT8D1 ENPP2 RABGAP1L MYO1F ALDH1L1 PLOD2	8.47e-04	774	76	8	C0023893
Disease	Hypercholesterolemia, Familial	LDLRAP1 APOB	9.75e-04	18	76	2	C0020445
Disease	hypothyroidism (biomarker_via_orthology)	PLOD3 PLOD2 SOD2	1.17e-03	80	76	3	DOID:1459 (biomarker_via_orthology)
Disease	mean platelet volume	LDLRAP1 ARHGAP32 CLN3 GRAP2 EML6 CHD9 LY75 RCC2 PLCE1	1.22e-03	1020	76	9	EFO_0004584
Disease	platelet measurement	LDLRAP1 CLN3 EML6 CHD9 LY75	1.34e-03	315	76	5	EFO_0005036
Disease	Attention Deficit Disorder	GRM7 GRM8	1.46e-03	22	76	2	C0041671
Disease	Minimal Brain Dysfunction	GRM7 GRM8	1.46e-03	22	76	2	C1321905
Disease	platelet reactivity measurement, response to clopidogrel	GRM7 PLCE1	1.60e-03	23	76	2	EFO_0004985, GO_1903493
Disease	Attention deficit hyperactivity disorder	GRM7 GRM8	1.74e-03	24	76	2	C1263846
Disease	alcohol use disorder measurement, alcohol consumption measurement	CLN3 RABGAP1L TMPRSS5	2.03e-03	97	76	3	EFO_0007878, EFO_0009458
Disease	mammographic density percentage	GVINP1 PRKG1	2.54e-03	29	76	2	EFO_0006502

Protein segments in the cluster

Peptide	Gene	Start	Entry
QIWDGFIWLTATKGH	ERVPABLB-1	191	P60509
LADPNHWRFQGGKWV	EOMES	321	O95936
WHKGLLGLSNATVEW	ASAH2B	106	P0C7U1
LHLGGIYWWKAISEG	GVINP1	356	Q7Z2Y8
SPWIQQHGGWEKILG	BCL2L14	306	Q9BZR8
RGISARVWGHFPKWL	BCO2	66	Q9BYV7
RVWGHFPKWLNGSLL	BCO2	71	Q9BYV7
AQGLILHFLGRAWTW	ATG4C	121	Q96DT6
LEWLWKFTGEGATAH	CHDH	366	Q8NE62
LWSWGRNEKGQLGHG	RCC2	171	Q9P258
GGSHWFKQKIIGLWN	GPR141	286	Q7Z602
GKNLLVSGWWGFVRH	LBR	531	Q14739
GALHSLAGARKWLEW	PEX10	31	O60683
SWGGGGRHRKLPENW	LDLRAP1	21	Q5SW96
HGKLWSNFWGALSPD	PLOD3	421	O60568
GGTSVWYHVLWGEKI	KDM7A	286	Q6ZMT4
HGWNRVGSTATKWFT	LEXM	11	Q3ZCV2
WLIWSLTGGVNGGVH	GK3P	181	Q14409
LWGLENSGWLRHIKA	MTMR7	301	Q9Y216
VWTWGKGDYFRLGHG	HERC2	3226	O95714
HKWFEGFNWEGLRKG	PRKG1	616	Q13976
GRWHLVDSTWGSGLV	KY	276	Q8NBH2
WHKGLLGLSNATVEW	ASAH2	721	Q9NR71
PHGWGGLSKQGRAFW	KIAA1614	1166	Q5VZ46
GLSKQGRAFWLWSEA	KIAA1614	1171	Q5VZ46
FSGGWLWRFKARHGI	JRK	131	O75564
RGGFNWGLHFKWDLV	GALNT11	291	Q8NCW6
LGRGWGREENLFSWK	COIL	391	P38432
ALHWLGAWIKEGGQR	LRRC24	211	Q50LG9
SGQHWLWIGLNKRSP	LY75	706	O60449
LLHWNGHLKPWGRTA	GLT8D1	326	Q68CQ7
SKTGHGKAVDWWSLG	RPS6KA4	211	O75676
LSTWWRGKHGFQVGL	ARHGAP32	296	A7KAX9
GHFLWIGSDSWGSKI	GRM8	301	O00222
YSWGELLGKWHSNLG	RABGAP1L	511	Q5R372
PLVTRHGKLWSNFWG	PLOD2	416	O00469
HGKLWSNFWGALSPD	PLOD2	421	O00469
GAWKNGHWTGLVGDL	GRIN3A	606	Q8TCU5
TWFLAAGLKWGHEAI	FZD4	326	Q9ULV1
VLHSIVGWGSTVGRW	GMPPA	336	Q96IJ6
AGHIAWTSSGKGSWK	APOB	2916	P04114
GWGRWREILSHGRFK	CHD9	1506	Q3L8U1
NLTGHFLWVGSDSWG	GRM6	296	O15303
HTKGLLLWNRVQGFW	DNASE2B	126	Q8WZ79
WLIWSLTGGVNGGVH	GK2	181	Q14410
IFGWGRWKDILTHGR	CHD6	1106	Q8TD26
EWHITKGGNIGAKWT	HSD17B4	651	P51659
KRNWFWGHLGLITPT	CYP4F12	56	Q9HCS2
WLIWSLTGGVNGGVH	GK	181	P32189
WGGSVLWLEGGHRLF	ITGA10	396	O75578
GHFLWVGSDSWGSKI	GRM7	306	Q14831
WRWQEGAKVASRGGH	EML6	1491	Q6ZMW3
PSWWTGRLHNKLGLF	GRAP2	306	O75791
LVIWTHLGGIWAGHS	RTL8C	161	O15255
GREKFNHRWWGGQPL	ENPP2	246	Q13822
LWTDGRGVHYTNWGK	MRC1	1021	P22897
LFVRGLHGKSGTWWD	MRPL3	36	P09001
TFGQKGGNHWWFGIR	TMEM185A	261	Q8NFB2
TFRRKGGNHWWFGIR	TMEM185B	261	Q9H7F4
AWSSSSWHGRIKGGM	PLCE1	1186	Q9P212
IQSKGHGRAVDWWAL	PRKY	216	O43930
QGVGHWALSTWAGLK	MTG2	16	Q9H4K7
GAAEQLVKTGWRSWH	OCSTAMP	6	Q9BR26
LGKKLHQATWGGWSL	SLC47A1	236	Q96FL8
WIGTFLGHKGAVWGA	STRAP	51	Q9Y3F4
VVRKLGWGHFSTVWL	SRPK3	81	Q9UPE1
HNWIRGNDKVPGAWT	ALDH1L1	221	O75891
QGAHWKNAVGFWLLG	CLN3	31	Q13286
RQTGMWWRHLVAGGG	SLC25A25	181	Q6KCM7
GSWWLAVPGAGRFIK	STK19	286	P49842
QGWGFKDGIFHNSIW	TNFAIP6	16	P98066
RNIWHLVGIVSWGDG	TMPRSS11B	376	Q86T26
SHGGIQAFLTKVWWG	TRPM2	731	O94759
LIHPWKGGAQHTWGF	TEX52	81	A6NCN8
WGWDIGRGKLYHQSK	SPSB2	131	Q99619
WKFALRGSWEQDFGH	SUGP2	136	Q8IX01
FPKGSRCWVSGWGHT	TMPRSS5	336	Q9H3S3
SGRVELWHAGSWGTV	SCART1	796	Q4G0T1
NWWKGETHQGIGLFP	STAM	246	Q92783
GWGWLGFNKERGHLQ	SOD2	146	P04179
GLRVVKISWGQGHFW	WDR6	91	Q9NNW5
IQSKGHGRAVDWWAL	PRKX	216	P51817
TKTGLDTTGAWHAWG	ZFYVE26	2056	Q68DK2
LFGWAHFQKNLWLLG	TPCN2	146	Q8NHX9
LGGWRISGKWTSLNF	KEL	176	P23276
SGWWKGRLHGQEGLF	MYO1F	1076	O00160