Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	FUT4 FUT7	2.12e-04	6	76	2	GO:0017083
GeneOntologyMolecularFunction	alpha-(1->3)-fucosyltransferase activity	FUT4 FUT7	3.94e-04	8	76	2	GO:0046920
GeneOntologyMolecularFunction	actin binding	EPS8L2 ABL2 SPATA31A3 SPATA31A7 CAMSAP3 SPATA31A6 SPATA31A5 HCLS1	4.67e-04	479	76	8	GO:0003779
GeneOntologyBiologicalProcess	cell-cell adhesion	ROBO4 NLGN3 ITCH ABL2 PPM1F RC3H1 CAMSAP3 SMARCA4 CDHR5 IGSF9B GATA5 FUT4 FUT7 CDH4 MEX3B YTHDF2	1.53e-06	1077	76	16	GO:0098609
GeneOntologyCellularComponent	acrosomal vesicle	HEXB SPATA31A3 SPATA31A7 TSKS SPATA31A6 SPATA31A5	1.30e-04	206	79	6	GO:0001669
MousePheno	abnormal response to new environment	SHANK1 HEXB NLGN3 ITCH ABL2 NEDD4L GAREM2 CARMIL3 FOSB AUTS2 IGSF9B CHAMP1	2.40e-05	687	59	12	MP:0001413
MousePheno	abnormal kidney morphology	HEXB IL12RB2 PNKP ITCH CLCN2 NEDD4L MEGF8 CARMIL3 FOSB RC3H1 TNS2 GATA5 FUT4 CDH4 MEX3B HCLS1 HR	3.07e-05	1363	59	17	MP:0002135
MousePheno	abnormal exploration in a new environment	SHANK1 HEXB NLGN3 ITCH NEDD4L GAREM2 CARMIL3 FOSB AUTS2 IGSF9B CHAMP1	7.05e-05	647	59	11	MP:0013189
MousePheno	abnormal response to novelty	SHANK1 HEXB NLGN3 ITCH ABL2 NEDD4L GAREM2 CARMIL3 FOSB AUTS2 IGSF9B CHAMP1	9.01e-05	787	59	12	MP:0003107
MousePheno	abnormal learning/memory/conditioning	SHANK1 HEXB NLGN3 NPR2 EPS8L2 ITCH ABL2 FOXO6 NEDD4L GAREM2 CARMIL3 FOSB AUTS2 IGSF9B CHAMP1	1.43e-04	1239	59	15	MP:0002063
MousePheno	abnormal cognition	SHANK1 HEXB NLGN3 NPR2 EPS8L2 ITCH ABL2 FOXO6 NEDD4L GAREM2 CARMIL3 FOSB AUTS2 IGSF9B CHAMP1	1.52e-04	1246	59	15	MP:0014114
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	1.29e-07	12	77	4	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	1.29e-07	12	77	4	IPR027970
Domain	AUTS2	FBRSL1 AUTS2	5.02e-05	3	77	2	IPR023246
Domain	Glyco_transf_10	FUT4 FUT7	4.62e-04	8	77	2	PF00852
Domain	Glyco_tran_10_N	FUT4 FUT7	4.62e-04	8	77	2	PF17039
Domain	PTB	EPS8L2 TNS2	4.62e-04	8	77	2	PF08416
Domain	PTB	EPS8L2 TNS2	4.62e-04	8	77	2	IPR013625
Domain	Glyco_trans_10	FUT4 FUT7	4.62e-04	8	77	2	IPR001503
Domain	Glyco_tran_10_N	FUT4 FUT7	4.62e-04	8	77	2	IPR031481
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	4.29e-10	6	82	4	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	4.29e-10	6	82	4	25930072
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	2.94e-07	24	82	4	32212159
Pubmed	Lack of functional selectin ligand interactions compromises long term tumor protection by CD8+ T cells.	FUT4 FUT7	5.49e-06	2	82	2	22359671
Pubmed	α(1,3)-Fucosyltransferases FUT4 and FUT7 control murine susceptibility to thrombosis.	FUT4 FUT7	5.49e-06	2	82	2	23562273
Pubmed	Lack of functional selectin-ligand interactions enhances innate immune resistance to systemic Listeria monocytogenes infection.	FUT4 FUT7	5.49e-06	2	82	2	29345354
Pubmed	The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis.	FUT4 FUT7	5.49e-06	2	82	2	8752218
Pubmed	Fucosyltransferase 4 and 7 mediates adhesion of non-small cell lung cancer cells to brain-derived endothelial cells and results in modification of the blood-brain-barrier: in vitro investigation of CD15 and CD15s in lung-to-brain metastasis.	FUT4 FUT7	5.49e-06	2	82	2	31104223
Pubmed	The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing.	FUT4 FUT7	5.49e-06	2	82	2	11485743
Pubmed	Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart.	FUT4 FUT7	5.49e-06	2	82	2	16709814
Pubmed	Memory T cells are enriched in lymph nodes of selectin-ligand-deficient mice.	FUT4 FUT7	5.49e-06	2	82	2	20937846
Pubmed	Selectin ligand-independent priming and maintenance of T cell immunity during airborne tuberculosis.	FUT4 FUT7	5.49e-06	2	82	2	16394002
Pubmed	Synthesis of {alpha}(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin.	FUT4 FUT7	5.49e-06	2	82	2	16127157
Pubmed	Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII.	FUT4 FUT7	5.49e-06	2	82	2	15579466
Pubmed	Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes.	FUT4 FUT7	5.49e-06	2	82	2	11535629
Pubmed	Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4+ T Cells.	FUT4 FUT7	5.49e-06	2	82	2	29491007
Pubmed	Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis.	FUT4 FUT7	5.49e-06	2	82	2	19608009
Pubmed	Pathophysiological contributions of fucosyltransferases in renal ischemia reperfusion injury.	FUT4 FUT7	5.49e-06	2	82	2	12193737
Pubmed	RNF11 sequestration of the E3 ligase SMURF2 on membranes antagonizes SMAD7 down-regulation of transforming growth factor β signaling.	ITCH NEDD4L DZIP3	8.39e-06	17	82	3	28292929
Pubmed	Silencing α1,3-fucosyltransferases in human leukocytes reveals a role for FUT9 enzyme during E-selectin-mediated cell adhesion.	FUT4 FUT7	1.64e-05	3	82	2	23192350
Pubmed	Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum.	FUT4 FUT7	1.64e-05	3	82	2	12869507
Pubmed	A role for leukocyte-endothelial adhesion mechanisms in epilepsy.	FUT4 FUT7	1.64e-05	3	82	2	19029985
Pubmed	Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII.	FUT4 FUT7	1.64e-05	3	82	2	15843584
Pubmed	Cdx2 Regulates Gene Expression through Recruitment of Brg1-associated Switch-Sucrose Non-fermentable (SWI-SNF) Chromatin Remodeling Activity.	CDX1 SMARCA4	1.64e-05	3	82	2	28082674
Pubmed	Naïve T cells re-distribute to the lungs of selectin ligand deficient mice.	FUT4 FUT7	1.64e-05	3	82	2	20532047
Pubmed	Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment.	FUT4 FUT7	1.64e-05	3	82	2	16352740
Pubmed	T-cell P/E-selectin ligand alpha(1,3)fucosylation is not required for graft-vs-host disease induction.	FUT4 FUT7	1.64e-05	3	82	2	16338500
Pubmed	Binding of L-selectin to its vascular and extravascular ligands is differentially regulated by pH.	FUT4 FUT7	1.64e-05	3	82	2	21982762
Pubmed	Alpha(1,3)fucosyltransferases FucT-IV and FucT-VII control susceptibility to atherosclerosis in apolipoprotein E-/- mice.	FUT4 FUT7	1.64e-05	3	82	2	15308551
Pubmed	Metastatic growth progression caused by PSGL-1-mediated recruitment of monocytes to metastatic sites.	FUT4 FUT7	1.64e-05	3	82	2	24322980
Pubmed	CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV.	FUT4 FUT7	1.64e-05	3	82	2	11278338
Pubmed	Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance.	FUT4 FUT7	1.64e-05	3	82	2	32341362
Pubmed	α(1,3) Fucosyltransferases IV and VII are essential for the initial recruitment of basophils in chronic allergic inflammation.	FUT4 FUT7	1.64e-05	3	82	2	23657464
Pubmed	Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity.	FUT4 FUT7	1.64e-05	3	82	2	22388819
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	SCAF1 FOXO6 NEDD4L RC3H1 DZIP3 CDH4 MEX3B	2.26e-05	358	82	7	32460013
Pubmed	Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.	ITCH ABL2 NEDD4L	2.80e-05	25	82	3	23873930
Pubmed	Monocyte Induction of E-Selectin-Mediated Endothelial Activation Releases VE-Cadherin Junctions to Promote Tumor Cell Extravasation in the Metastasis Cascade.	FUT4 FUT7	3.28e-05	4	82	2	27488527
Pubmed	The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations.	FUT4 FUT7	3.28e-05	4	82	2	23986452
Pubmed	Arteriogenesis proceeds via ICAM-1/Mac-1- mediated mechanisms.	FUT4 FUT7	3.28e-05	4	82	2	15059933
Pubmed	Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction.	FUT4 FUT7	3.28e-05	4	82	2	18755847
Pubmed	A novel monoclonal antibody against 6-sulfo sialyl Lewis x glycans attenuates murine allergic rhinitis by suppressing Th2 immune responses.	FUT4 FUT7	3.28e-05	4	82	2	37735247
Pubmed	Heparin-induced leukocytosis requires 6-O-sulfation and is caused by blockade of selectin- and CXCL12 protein-mediated leukocyte trafficking in mice.	FUT4 FUT7	3.28e-05	4	82	2	22194593
Pubmed	The Ubiquitin Ligase Itch and Ubiquitination Regulate BFRF1-Mediated Nuclear Envelope Modification for Epstein-Barr Virus Maturation.	ITCH NEDD4L	3.28e-05	4	82	2	27466427
Pubmed	Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels.	FUT4 FUT7	3.28e-05	4	82	2	10894166
Pubmed	Notch-dependent control of myelopoiesis is regulated by fucosylation.	FUT4 FUT7	3.28e-05	4	82	2	18359890
Pubmed	Expression of functional P-selectin glycoprotein ligand 1 on hematopoietic progenitors is developmentally regulated.	FUT4 FUT7	3.28e-05	4	82	2	22461691
Pubmed	Erythropoietin improves skin wound healing and activates the TGF-β signaling pathway.	EPOR HR	3.28e-05	4	82	2	21894148
Pubmed	Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitis.	FUT4 FUT7	3.28e-05	4	82	2	18056398
Pubmed	Molecular cloning, expression, chromosomal assignment, and tissue-specific expression of a murine alpha-(1,3)-fucosyltransferase locus corresponding to the human ELAM-1 ligand fucosyl transferase.	EPOR FUT4	3.28e-05	4	82	2	7559635
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ITCH ABL2 NEDD4L KCNA7 MEGF8 TRIP6 CAMSAP3 KIAA1191 MEX3B YTHDF2	3.51e-05	861	82	10	36931259
Pubmed	The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics.	FUT4 FUT7	5.47e-05	5	82	2	18037890
Pubmed	N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules.	FUT4 FUT7	5.47e-05	5	82	2	16227985
Pubmed	Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.	ITCH NEDD4L	5.47e-05	5	82	2	25631046
Pubmed	The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation.	ITCH NEDD4L	5.47e-05	5	82	2	22385262
Pubmed	N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking.	ITCH NEDD4L	8.19e-05	6	82	2	15252135
Pubmed	Novel anti-carbohydrate antibodies reveal the cooperative function of sulfated N- and O-glycans in lymphocyte homing.	FUT4 FUT7	8.19e-05	6	82	2	20929857
Pubmed	Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3.	ITCH NEDD4L	8.19e-05	6	82	2	26854353
Pubmed	Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals.	ITCH NEDD4L	8.19e-05	6	82	2	23886940
Pubmed	Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4.	FUT4 FUT7	8.19e-05	6	82	2	20368416
Pubmed	L-selectin mechanochemistry restricts neutrophil priming in vivo.	FUT4 FUT7	8.19e-05	6	82	2	28497779
Pubmed	Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice.	ITCH NEDD4L	8.19e-05	6	82	2	37156795
Pubmed	Functional contributions of N- and O-glycans to L-selectin ligands in murine and human lymphoid organs.	FUT4 FUT7	8.19e-05	6	82	2	21224079
Pubmed	N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.	ITCH NEDD4L	8.19e-05	6	82	2	11748237
Pubmed	Physiological contribution of CD44 as a ligand for E-Selectin during inflammatory T-cell recruitment.	FUT4 FUT7	8.19e-05	6	82	2	21457936
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	SCAF1 MEGF8 TRIP6 DZIP3 TNS2 GCC1 PRRC2A HCLS1	9.54e-05	608	82	8	16713569
Pubmed	An AUTS2-Polycomb complex activates gene expression in the CNS.	PPP1R8 AUTS2 MEX3B	1.00e-04	38	82	3	25519132
Pubmed	Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice.	FUT4 FUT7	1.14e-04	7	82	2	23677475
Pubmed	Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis.	ITCH NEDD4L	1.14e-04	7	82	2	31845480
Pubmed	Hierarchical CRMP2 posttranslational modifications control NaV1.7 function.	ITCH NEDD4L	1.14e-04	7	82	2	27940916
Pubmed	DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance.	FUT4 FUT7	1.14e-04	7	82	2	26070485
Pubmed	Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases.	ITCH NEDD4L	1.14e-04	7	82	2	11046148
Pubmed	Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming.	ITCH NEDD4L	1.14e-04	7	82	2	23644597
Pubmed	The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.	ITCH NEDD4L	1.52e-04	8	82	2	11244092
Pubmed	Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.	ITCH NEDD4L	1.52e-04	8	82	2	17719543
Pubmed	Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse.	NPR2 HR	1.52e-04	8	82	2	16461637
Pubmed	Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination.	DZIP3 MEX3B	1.96e-04	9	82	2	24326307
Pubmed	Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia.	HOXB2 CDX1	1.96e-04	9	82	2	12242306
Pubmed	Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17.	FUT4 FUT7	1.96e-04	9	82	2	15780986
Pubmed	Regulation of Hoxb3 expression in the hindbrain and pharyngeal arches by rae28, a member of the mammalian Polycomb group of genes.	HOXB2 CDX1	1.96e-04	9	82	2	11044623
Pubmed	Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.	ITCH NEDD4L	2.44e-04	10	82	2	25092867
Pubmed	Inflammasome activation and metabolic remodelling in p16-positive aging cells aggravates high-fat diet-induced lung fibrosis by inhibiting NEDD4L-mediated K48-polyubiquitin-dependent degradation of SGK1.	ABL2 NEDD4L	2.44e-04	10	82	2	37345264
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SCAF1 IL12RB2 ITCH TRIP6 FBRSL1 SMARCA4 C16orf96 SOWAHC CHAMP1 IRX2	2.93e-04	1116	82	10	31753913
Pubmed	ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer.	ITCH NEDD4L	2.98e-04	11	82	2	34927784
Pubmed	Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response.	FUT4 FUT7	2.98e-04	11	82	2	19303390
Pubmed	USP11 augments TGFβ signalling by deubiquitylating ALK5.	ITCH NEDD4L	2.98e-04	11	82	2	22773947
Pubmed	Behavioral phenotypes of genetic mouse models of autism.	SHANK1 NLGN3	2.98e-04	11	82	2	26403076
Pubmed	Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein.	ITCH NEDD4L	2.98e-04	11	82	2	25963657
Pubmed	HOTAIR induces the ubiquitination of Runx3 by interacting with Mex3b and enhances the invasion of gastric cancer cells.	DZIP3 MEX3B	2.98e-04	11	82	2	29417297
Pubmed	Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera.	CDX1 GATA5 LTBR	3.03e-04	55	82	3	10926756
Pubmed	Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch.	ITCH NEDD4L	4.21e-04	13	82	2	23146885
Pubmed	K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling.	ITCH NEDD4L	4.91e-04	14	82	2	31015455
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	NLGN3 CAMSAP3 GPRIN1	5.43e-04	67	82	3	29254152
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	SHANK1 NLGN3 ABL2 CAMSAP3 GPRIN1	5.46e-04	281	82	5	28706196
Pubmed	A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.	AUTS2 CMTM5 MSL1 SEC31B CDH4 YTHDF2	5.54e-04	431	82	6	33660365
Pubmed	Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism.	FUT4 FUT7	5.65e-04	15	82	2	11698403
Pubmed	Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins.	ITCH NEDD4L	5.65e-04	15	82	2	23236378
Pubmed	A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.	ITCH NEDD4L	6.45e-04	16	82	2	22496338
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	PNKP CAMSAP3 SMARCA4 CHAMP1	6.70e-04	167	82	4	20362541
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	PPP1R8 NPR2 NEDD4L MEGF8 PPM1F TNS2 CDHR5 LTBR FBXL19	6.73e-04	1021	82	9	26760575
Pubmed	A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development.	EPOR SMARCA4	7.30e-04	17	82	2	16287714
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	8.76e-05	8	82	2	chr9q12
Cytoband	19q13.3-q13.4	SCAF1 PNKP	2.43e-04	13	82	2	19q13.3-q13.4
Cytoband	19q13.3	SHANK1 KCNA7 TSKS	4.39e-04	82	82	3	19q13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	SHANK1 GARIN5B SCAF1 PNKP KCNA7 MEGF8 FOSB TSKS	1.32e-03	1192	82	8	chr19q13
Cytoband	5q35.2	KIAA1191 GPRIN1	1.51e-03	32	82	2	5q35.2
GeneFamily	Fucosyltransferases\|Blood group antigens	FUT4 FUT7	4.64e-04	13	45	2	434
GeneFamily	Fibronectin type III domain containing	EPOR ROBO4 IL12RB2 IGSF9B	6.64e-04	160	45	4	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	ROBO4 PXDNL WFIKKN1 IGSF9B	6.79e-04	161	45	4	593
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PPP1R8 CAMSAP3 DZIP3 TSKS	1.05e-03	181	45	4	694
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	NPR2 DENND3	1.75e-03	25	45	2	504
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ITCH NEDD4L	3.62e-03	36	45	2	823
GeneFamily	WD repeat domain containing	WDR93 SEC31B WDFY4 DENND3	4.03e-03	262	45	4	362
GeneFamily	HOXL subclass homeoboxes	HOXB2 CDX1	7.42e-03	52	45	2	518
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HEXB FUT7 SOWAHC WDFY4 HCLS1 HR	8.37e-07	176	81	6	a85ad8b4815fde72edd5c900e882a0bc04033ea8
ToppCell	facs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR CLCN2 SPPL2B RAB3IL1 HR	1.39e-05	168	81	5	17fb9426eeea407b26fb895b8397faca95b7552d
ToppCell	facs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPOR CLCN2 SPPL2B RAB3IL1 HR	1.39e-05	168	81	5	a61b39884851384cffd430079040546d125b2b40
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPS8L2 NEDD4L FOSB IRX2 DENND3	1.43e-05	169	81	5	cd16e8462ee09877be962fbd9a3badcb825820b0
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NLGN3 NPR2 TNS2 CMTM5 GCC1	1.70e-05	175	81	5	a5db428b078938627e61b7e944c1e0c1d61ac2da
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NLGN3 NPR2 TNS2 CMTM5 GCC1	1.70e-05	175	81	5	8b498eea1ec1c1f27b171025c3d08adf3687bafc
ToppCell	droplet-Lung-nan-21m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXB2 IGSF9B GATA5 PLAC9 CDH4	2.10e-05	183	81	5	b153425ab0df1e5fa9b953e1f6d4e8e3dc6621b0
ToppCell	droplet-Lung-nan-21m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HOXB2 IGSF9B GATA5 PLAC9 CDH4	2.10e-05	183	81	5	19e7be1cfdd111bfb840532a6f7c780345dffccf
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	EPS8L2 NEDD4L FOSB IRX2 DENND3	2.33e-05	187	81	5	4ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HOXB2 NLGN3 GATA5 PLAC9 CDH4	2.33e-05	187	81	5	8bd635abdee5d5a12a3f7bf74eab4282e8e40741
ToppCell	droplet-Lung-18m-Mesenchymal-myofibroblast-myofibroblast_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HOXB2 NLGN3 GATA5 PLAC9 CDH4	2.33e-05	187	81	5	3cb8cd7f7a4306ff74d1f7f9964014008ec1c6a0
ToppCell	droplet-Lung-21m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HOXB2 IGSF9B GATA5 PLAC9 CDH4	2.45e-05	189	81	5	cd42ce4aa217d0bd95e0cc0ba357bdfeb3e55a48
ToppCell	droplet-Lung-21m-Mesenchymal-myofibroblast-myofibroblast_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HOXB2 IGSF9B GATA5 PLAC9 CDH4	2.45e-05	189	81	5	102501eee7760d5882dec41ea9d00147b3f4fb73
ToppCell	droplet-Lung-21m-Mesenchymal-myofibroblast\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HOXB2 IGSF9B GATA5 PLAC9 CDH4	2.45e-05	189	81	5	6e83bf855d4771885b60bb8992df2f9b508eef97
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FUT7 ZBED3 WDFY4 HCLS1 HR	2.78e-05	194	81	5	5a048bd2af30975fdc57ff40bc49aa5811c830d8
ToppCell	facs-Thymus-Epithelium-24m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 FOSB TNS2 IRX2 HR	2.85e-05	195	81	5	cc89261bb091ef978bd73cffc68ccdd00a8786d1
ToppCell	Bronchus_Control_(B.)-Endothelial-TX-Bronchial_vessel\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	IL12RB2 TCERG1L FOXO6 TSKS IRX2	3.07e-05	198	81	5	dcf334d13e5b0018fee24febccfef91c9e17843b
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	EPOR LTBR RAB3IL1 DENND3 HCLS1	3.22e-05	200	81	5	0eccf41edefc3b8b5d0316f57d5ba572949aec2b
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal-BMP_responsible_cell\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	EPOR LTBR RAB3IL1 DENND3 HCLS1	3.22e-05	200	81	5	01d707c4f8ee0daac635b7260937b1baebc6fc23
Disease	Bicuspid aortic valve	ROBO4 GATA5	5.84e-05	5	72	2	C0149630
Disease	alcohol use disorder (implicated_via_orthology)	EPS8L2 FBRSL1 SMARCA4 AUTS2 HR	1.17e-04	195	72	5	DOID:1574 (implicated_via_orthology)
Disease	airway responsiveness measurement	DZIP3 WDFY4	1.57e-03	24	72	2	EFO_0006897
Disease	Child Development Disorders, Specific	PNKP WDFY4	2.28e-03	29	72	2	C0085997
Disease	Child Development Deviations	PNKP WDFY4	2.28e-03	29	72	2	C0085996

Protein segments in the cluster

Peptide	Gene	Start	Entry
SKINPPPWAPACLPG	LINC01547	151	P58512
PSFPAPPPWPKSVDA	FBRSL1	741	Q9HCM7
APPTAWGAPFPAPKD	CDX1	56	P47902
PSHWPPFVPPAKPEV	ATG4A	356	Q8WYN0
APAVEPKPAWEEPPP	CDRT15L2	101	A8MXV6
PGWPSPAKAAPVLPT	ABL2	911	P42684
LGWPAVSPKPMPELP	BPIFB4	396	P59827
PWVKGAPPSDNPPCA	NPR2	426	P20594
WAPVPSPTHDPKPAE	CDHR5	726	Q9HBB8
WKGLPGPPRAPEPED	DENND3	16	A2RUS2
PEAPGSAPPPAAWVI	CAMSAP3	731	Q9P1Y5
GLPPENWEKPKPPLA	FBXL19	276	Q6PCT2
GLPPPLAAVPVPWKS	RAB3IL1	11	Q8TBN0
PPPPKWPGMISSEQL	RC3H1	1011	Q5TC82
DLVKGPPDWPPPWGI	FUT4	241	P22083
DPKPENPACPWTVLP	IL12RB2	776	Q99665
LCPEGWAPTPPPSRK	KIAA1614	801	Q5VZ46
AKLQDPALAPWPPKP	CARMIL3	1266	Q8ND23
TPDSWLPPGFPQGPK	HR	56	O43593
LEPHWGPSPPLPAKS	FUT7	156	Q11130
PSAPAPGPVPAAAKW	FOXO6	216	A8MYZ6
PPPWLKPGELERSAS	AUTS2	806	Q8WXX7
PASAWKPAGLPPPAF	MEGF8	2711	Q7Z7M0
PGPESKISPFWVMPP	MPND	396	Q8N594
PPSDMGSVPWKPVIP	KIAA1191	46	Q96A73
WGGSVPLPCPPPATK	MSL1	96	Q68DK7
PDAAQPPKPAWRPLT	DZIP3	1111	Q86Y13
PPKPAWRPLTSQGPA	DZIP3	1116	Q86Y13
WGPASPTHKLPPSFP	EPS8L2	566	Q9H6S3
TSPGAPPPASKPKLW	IRX2	316	Q9BZI1
PAKEDGFSWLLPPPP	FOSB	246	P53539
LPAAPPAPEFPWMKE	HOXB2	86	P14652
SKEFDPLGPLPPGWE	ITCH	431	Q96J02
EKRFLPPEPPPSWSG	NLGN3	81	Q9NZ94
WPPSGKPLLPFSTGP	PXDNL	926	A1KZ92
PSPQPPELAARPGWA	GATA5	51	Q9BWX5
PARGPPPPKSEEASW	GCC1	121	Q96CN9
PPPLWAPPGKHLVTE	KCNA7	441	Q96RP8
GSLPAPWPVLGPVPA	C16orf96	361	A6NNT2
SPEPWKPFPAVSPEP	CHAMP1	286	Q96JM3
SGPWKPAKPAPSVSP	CHAMP1	331	Q96JM3
PAAKTGCPPLWPNPA	GCM1	346	Q9NP62
ALDPSPPPKDTLLPW	CDH4	141	P55283
GAAWAPPPNLPDPKF	EPOR	21	P19235
KAPSWEASAPPPPRE	GPRIN1	796	Q7Z2K8
PSVSAKPGPALWPLP	HEXB	46	P07686
PALLNPEDPLPWKAP	PPM1F	31	P49593
APAPPPGAPLIWAQF	MEX3B	366	Q6ZN04
SPDWAAAPEPAAPPA	GAREM2	411	Q75VX8
LPLFDCPTWAGKPPP	PPP1R8	11	Q12972
PAPLPKKISSEAWPP	HCLS1	291	P14317
PLKPPPAGQEGRWPS	SPATA31A6	906	Q5VVP1
GIPSWNDHEPLKPPP	SPATA31A7	901	Q8IWB4
PRPLPWPPGSDEVAK	PRRC2A	861	P48634
PKPWPEGPMANAAAP	SMARCA4	281	P51532
WLESPPGGAPPIFLP	PNKP	11	Q96T60
EGEPPAPAHWPPLSA	SOWAHC	136	Q53LP3
PHPGPQDSWKEAPAP	SEC31B	986	Q9NQW1
QPGLPSPAMIPKDWP	ERVK-9	1026	P63128
NPDPAEGPKPRPAVW	ROBO4	251	Q8WZ75
PPAPHPGVSKPWRSA	SHANK1	1466	Q9Y566
PAAVPWVPAPAPGFW	CMTM5	131	Q96DZ9
PEPWKGPPSSRAAPE	CLCN2	46	P51788
LGWAPAAPPPLKDDP	ZBED3	206	Q96IU2
APLLPGLPGWPAPSE	TCERG1L	71	Q5VWI1
GLPGWPAPSEPVLPL	TCERG1L	76	Q5VWI1
GIPSWNDHEPLKPPP	SPATA31A3	901	Q5VYP0
MSGPTWLPPKQPEPA	TRIP6	1	Q15654
GIPSWNDHEPLKPPP	SPATA31A5	901	Q5VU36
ELAWNLPPGPFSPAP	PLAC9	76	Q5JTB6
GPVPAPPAAKWQDRP	IGSF9B	1111	Q9UPX0
PAPPAPASPWDSKKH	SCAF1	541	Q9H7N4
KVLPPSPWAPAPADG	SPPL2B	506	Q8TCT7
SPWAPAPADGPQPPK	SPPL2B	511	Q8TCT7
EPPAQPPSPRGHKWE	WDFY4	3116	Q6ZS81
LAGPPASPTLPWDPD	TSKS	111	Q9UJT2
PPAKGASLLHPWSPP	PYCARD-AS1	126	I3L0S3
PNPVAGSWEPPKAHP	LTBR	271	P36941
PCKHVLSWPPSSPGP	WFIKKN1	156	Q96NZ8
APPGAFPLEVPWKPV	WDR93	561	Q6P2C0
LMPSPGALLPWPAPF	PRR29	116	P0C7W0
ATPPPSAQPWKGDPV	TNS2	1181	Q63HR2
AALLPPEVGVPWGLP	TYSND1	321	Q2T9J0
LPPATIAPPKPASWA	YTHDF2	226	Q9Y5A9
AAEPPSASPQAPWPK	UNQ6493/PRO21345	91	Q6UXR8
KLPAVPASSWKPPPG	GARIN5B	421	Q8N5Q1
PPPPLPPGWEEKVDN	NEDD4L	191	Q96PU5