Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	anandamide 8,9 epoxidase activity	CYP2D7 CYP2D6	4.79e-05	4	57	2	GO:0062187
GeneOntologyMolecularFunction	anandamide 11,12 epoxidase activity	CYP2D7 CYP2D6	4.79e-05	4	57	2	GO:0062188
GeneOntologyMolecularFunction	steroid 21-monooxygenase activity	CYP2D7 CYP2D6	4.79e-05	4	57	2	GO:0004509
GeneOntologyMolecularFunction	progesterone 21-hydroxylase activity	CYP2D7 CYP2D6	4.79e-05	4	57	2	GO:0106309
GeneOntologyMolecularFunction	anandamide 14,15 epoxidase activity	CYP2D7 CYP2D6	1.19e-04	6	57	2	GO:0062189
GeneOntologyMolecularFunction	anandamide epoxidase activity	CYP2D7 CYP2D6	1.19e-04	6	57	2	GO:0062186
GeneOntologyBiologicalProcess	serotonin biosynthetic process from tryptophan	CYP2D7 CYP2D6	2.25e-05	3	57	2	GO:0006587
Domain	Death	PIDD1 DTHD1	4.24e-03	33	55	2	PF00531
Domain	Death_domain	PIDD1 DTHD1	5.59e-03	38	55	2	IPR000488
Domain	DEATH_DOMAIN	PIDD1 DTHD1	5.59e-03	38	55	2	PS50017
Pubmed	Biological insights from 108 schizophrenia-associated genetic loci.	PRR12 CYP2D6 TSR1 ACTR5 NAB2 FES MYO15A	6.47e-07	303	57	7	25056061
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HIVEP3 PRR12 IGF1R KANSL1 PLEKHO2 TMEM158 MBD6 CABIN1 ZNF865 MFSD5 AHNAK2	1.53e-06	1105	57	11	35748872
Pubmed	Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells.	CYP2D7 CYP2D6	2.64e-06	2	57	2	11032406
Pubmed	Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion.	CYP2D7 CYP2D6	2.64e-06	2	57	2	25808902
Pubmed	Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?	CYP2D7 CYP2D6	2.64e-06	2	57	2	11207030
Pubmed	Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.	CYP2D7 CYP2D6	2.64e-06	2	57	2	3123997
Pubmed	The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.	CYP2D7 CYP2D6	2.64e-06	2	57	2	19594327
Pubmed	Coding-noncoding gene expression in intrahepatic cholangiocarcinoma.	CYP2D7 CYP2D6	2.64e-06	2	57	2	26297049
Pubmed	A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.	CYP2D7 CYP2D6	2.64e-06	2	57	2	15051713
Pubmed	Insulin-like growth factor I receptor gene is concordant with c-Fes protooncogene and mouse chromosome 7 in somatic cell hybrids.	IGF1R FES	2.64e-06	2	57	2	2548293
Pubmed	The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.	CYP2D7 CYP2D6	7.91e-06	3	57	2	2574001
Pubmed	Identification of the primary gene defect at the cytochrome P450 CYP2D locus.	CYP2D7 CYP2D6	7.91e-06	3	57	2	1978251
Pubmed	Interaction network of human early embryonic transcription factors.	PRR12 ATN1 TET1 NAB2 BRD7 MBD6	2.38e-05	351	57	6	38297188
Pubmed	Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis.	NECTIN2 PARD3	2.63e-05	5	57	2	19116242
Pubmed	Regulation of Active DNA Demethylation through RAR-Mediated Recruitment of a TET/TDG Complex.	RARB TET1	2.63e-05	5	57	2	28538185
Pubmed	Kinase activation through dimerization by human SH2-B.	IGF1R SH2B1	2.63e-05	5	57	2	15767667
Pubmed	A molecular genetic linkage map of mouse chromosome 7.	IGF1R NECTIN2 FES	3.12e-05	37	57	3	1981054
Pubmed	Regulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins.	IGF1R SH2B1	3.94e-05	6	57	2	23190452
Pubmed	Polymorphism of metabolic genes and susceptibility to occupational chronic manganism.	CYP2D7 CYP2D6	3.94e-05	6	57	2	12171760
Pubmed	MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation.	IGF1R FES	3.94e-05	6	57	2	8787751
Pubmed	Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly.	COL4A6 PCDH12 PARD3	3.95e-05	40	57	3	27068110
Pubmed	The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family.	IGF1R FES	5.51e-05	7	57	2	2482828
Pubmed	Effects of infection of MRSA on the expression and activity of renal cytochrome P450s in mice.	CYP2D7 CYP2D6	5.51e-05	7	57	2	30944282
Pubmed	Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms.	ATN1 DENND4B	5.51e-05	7	57	2	8325628
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	TSR1 FAM120C PARD3 APOL2 MFSD5 ST6GALNAC2 AHNAK2 ZNF646	6.08e-05	832	57	8	36724073
Pubmed	Nectins localize Willin to cell-cell junctions.	NECTIN2 PARD3	7.34e-05	8	57	2	22512338
Pubmed	Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse.	NECTIN2 PARD3	9.43e-05	9	57	2	12515806
Pubmed	Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader-Willi syndrome region.	IGF1R FES	1.18e-04	10	57	2	1303276
Pubmed	The DNA sequence of human chromosome 22.	CACNA1I HDAC10 CABIN1 APOL2 MPPED1	1.34e-04	300	57	5	10591208
Pubmed	trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues.	IGF1R FES	1.44e-04	11	57	2	8223273
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	KANSL1 ATN1 ACTR5 TET1 DYRK1B MBD6	1.58e-04	495	57	6	27705803
Pubmed	Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes.	IGF1R FES	2.37e-04	14	57	2	1354647
Pubmed	Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities.	NECTIN2 PARD3	2.37e-04	14	57	2	24381198
Pubmed	A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing.	IGF1R FES	2.37e-04	14	57	2	8114702
Pubmed	Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains.	FES SH2B1	2.73e-04	15	57	2	10679268
Pubmed	Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese.	DGKG SH2B1	2.73e-04	15	57	2	20215397
Pubmed	Expression of aldehyde dehydrogenase family 1, member A3 in glycogen trophoblast cells of the murine placenta.	RARB PCDH12	3.12e-04	16	57	2	25577283
Pubmed	De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity.	NECTIN2 PARD3	3.97e-04	18	57	2	23487309
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	PRR12 TSR1 DYRK1B BRD7 MYO15A	4.92e-04	398	57	5	35016035
Pubmed	Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.	DGKG SH2B1	4.92e-04	20	57	2	19079260
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	IGF1R MAST4 TET1 NECTIN2 DYRK1B PARD3 AHNAK2	5.01e-04	861	57	7	36931259
Pubmed	Changes in gene-expression during development of the murine molar tooth germ.	AMBN BRD7	5.43e-04	21	57	2	17374359
Pubmed	Localization of growth arrest-specific genes on mouse chromosomes 1, 7, 8, 11, 13, and 16.	IGF1R FES	5.43e-04	21	57	2	1347472
Pubmed	The syntenic relationship of proximal mouse chromosome 7 and the myotonic dystrophy gene region on human chromosome 19q.	IGF1R FES	5.43e-04	21	57	2	2307474
Pubmed	The imprinted Phlda2 gene regulates extraembryonic energy stores.	IGF1R PCDH12	5.97e-04	22	57	2	19884348
Pubmed	Chromosomal mapping of five mouse G protein gamma subunits.	RARB NECTIN2	5.97e-04	22	57	2	10191100
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	MAST4 CABIN1 ZNF646	6.76e-04	104	57	3	9205841
Pubmed	Par3 is essential for the establishment of planar cell polarity of inner ear hair cells.	NECTIN2 PARD3	7.12e-04	24	57	2	30814219
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	COL4A6 IGF1R TM9SF1 LRP11 NECTIN2 LTBP1 APOL2 MFSD5	7.27e-04	1201	57	8	35696571
Pubmed	Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.	IGF1R FES	7.73e-04	25	57	2	15254900
Pubmed	Centrosome anchoring regulates progenitor properties and cortical formation.	PARD3 CEP164	7.73e-04	25	57	2	32238932
Pubmed	Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of PPAR-alpha knockout mouse.	AMBN BRD7	1.27e-03	32	57	2	19320717
Pubmed	Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.	COL4A6 LTBP1 TNXB	1.44e-03	135	57	3	28675934
Pubmed	Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy.	ATN1 BRD7 TRPT1	1.50e-03	137	57	3	30862715
Pubmed	Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens.	IGF1R FES	1.60e-03	36	57	2	9344654
Cytoband	Ensembl 112 genes in cytogenetic band chr22q13	CYP2D7 CYP2D6 CACNA1I HDAC10 MPPED1	5.74e-05	330	57	5	chr22q13
Cytoband	22q13.31	HDAC10 MPPED1	1.51e-03	46	57	2	22q13.31
GeneFamily	Cytochrome P450 family 2	CYP2D7 CYP2D6	2.20e-03	35	36	2	1001
GeneFamily	PDZ domain containing	MAST4 PARD3 AHNAK2	3.39e-03	152	36	3	1220
Coexpression	NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_DN	RARB MAST4 PLEKHO2 TM9SF1 NECTIN2 DYRK1B DGKG CACNA1I TNXB MFSD5 ST6GALNAC2	3.52e-06	909	57	11	M41018
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HIVEP3 RARB DGKG PCDH12 TNXB	4.58e-06	191	57	5	f663131a4810584c5854bd64ee7991a237b7707f
Drug	0179445-0000 [211246-22-9]; Down 200; 1uM; PC3; HT_HG-U133A	HIVEP3 COL4A6 ATN1 PLEKHO2 NAB2 CABIN1 ST6GALNAC2	5.78e-07	196	57	7	4292_DN
Drug	Delsoline [509-18-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A	MAST4 PER3 PLEKHO2 CACNA1I PARD3 CABIN1 CEP164	6.40e-07	199	57	7	6075_DN
Drug	1-chlorobutane	CYP2D7 CYP2D6 PACS2	1.24e-06	9	57	3	CID000008005
Drug	cupreidine	CYP2D7 CYP2D6	6.16e-06	2	57	2	CID000051196
Drug	3-methoxyphenethylamine	CYP2D7 CYP2D6	6.16e-06	2	57	2	CID000074866
Drug	Atractyloside potassium salt [102130-43-8]; Down 200; 5uM; PC3; HT_HG-U133A	HIVEP3 COL4A6 ATN1 PIDD1 ST6GALNAC2 SH2B1	9.22e-06	195	57	6	3695_DN
Drug	Graveoline [485-61-0]; Down 200; 14.4uM; PC3; HT_HG-U133A	HIVEP3 IGF1R FAM120C CABIN1 CEP164 SH2B1	9.50e-06	196	57	6	4276_DN
Drug	Iproniazide phosphate [305-33-9]; Down 200; 14.4uM; MCF7; HT_HG-U133A	HIVEP3 ATN1 FAM120C PLEKHO2 PARD3 SH2B1	9.50e-06	196	57	6	2288_DN
Drug	Fluorocurarine chloride [22273-09-2]; Down 200; 11.6uM; PC3; HT_HG-U133A	FAM120C PIDD1 CABIN1 APOL2 CEP164 ST6GALNAC2	9.50e-06	196	57	6	5741_DN
Drug	Vincamine [1617-90-9]; Up 200; 11.2uM; MCF7; HT_HG-U133A	COL4A6 FAM120C TMEM158 PARD3 AHNAK2 ZNF646	9.77e-06	197	57	6	2327_UP
Drug	clozapine; Down 200; 10uM; MCF7; HT_HG-U133A	MAST4 FAM120C PLEKHO2 PIDD1 APOL2 AHNAK2	9.77e-06	197	57	6	5589_DN
Drug	Antimycin A [1397-94-0]; Up 200; 7.2uM; PC3; HT_HG-U133A	HIVEP3 COL4A6 PCDH12 MYO15A ST6GALNAC2 ZNF646	1.01e-05	198	57	6	5053_UP
Drug	Minoxidil [38304-91-5]; Down 200; 19.2uM; MCF7; HT_HG-U133A	HIVEP3 ATN1 FAM120C PIDD1 CEP164 SH2B1	1.01e-05	198	57	6	4800_DN
Drug	Carbarsone [121-59-5]; Down 200; 15.4uM; PC3; HT_HG-U133A	ATN1 PLEKHO2 NAB2 NECTIN2 CABIN1 SH2B1	1.07e-05	200	57	6	3991_DN
Drug	chlorpromazine N-oxide	CYP2D7 CYP2D6	1.84e-05	3	57	2	CID000443037
Drug	2,4,6-trimethylbenzaldoxime	CYP2D7 CYP2D6	1.84e-05	3	57	2	CID000283782
Drug	O-demethyl encainide	CYP2D7 CYP2D6	1.84e-05	3	57	2	CID000054736
Drug	4,4'-difluorobenzophenone	CYP2D7 CYP2D6	3.68e-05	4	57	2	CID000009582
Drug	Z-10	CYP2D7 CYP2D6	3.68e-05	4	57	2	CID000477529
Drug	1-(1-phenylcyclohexyl)-4-piperidinol	CYP2D7 CYP2D6	3.68e-05	4	57	2	CID000098840
Drug	desethylaprindine	CYP2D7 CYP2D6	3.68e-05	4	57	2	CID000162697
Drug	eptapirone	CYP2D7 CYP2D6	6.13e-05	5	57	2	CID000208928
Drug	Koe 1801	CYP2D7 CYP2D6	6.13e-05	5	57	2	CID000129632
Drug	2Cmp	CYP2D7 CYP2D6	6.13e-05	5	57	2	CID000023392
Drug	L-754,394	CYP2D7 CYP2D6	6.13e-05	5	57	2	CID005481990
Drug	oxosparteine	CYP2D7 CYP2D6	6.13e-05	5	57	2	CID000097492
Drug	threohydrobupropion	CYP2D7 CYP2D6	6.13e-05	5	57	2	CID000000445
Drug	4-hydroxyochratoxin A	CYP2D7 CYP2D6	6.13e-05	5	57	2	CID000114713
Drug	fenproporex	CYP2D7 CYP2D6	6.13e-05	5	57	2	CID000061810
Drug	AC1O745W	CYP2D7 CYP2D6 CABIN1	7.01e-05	32	57	3	CID006518184
Drug	8-Methylxanthine	CYP2D7 CYP2D6	9.18e-05	6	57	2	CID000087061
Drug	AC1L45F6	CYP2D7 CYP2D6	9.18e-05	6	57	2	CID000150982
Drug	KRM1674	CYP2D7 CYP2D6	9.18e-05	6	57	2	CID000126235
Drug	5-dehydrosparteine	CYP2D7 CYP2D6	9.18e-05	6	57	2	CID000160614
Drug	nitroguanidine	CYP2D7 CYP2D6	9.18e-05	6	57	2	CID000011174
Drug	10-hydroxyochratoxin A	CYP2D7 CYP2D6	9.18e-05	6	57	2	CID000135115
Drug	7-hydroxychlorpromazine	CYP2D7 CYP2D6	9.18e-05	6	57	2	CID000016414
Drug	Withaferin A [5119-48-2]; Down 200; 1uM; MCF7; HT_HG-U133A	HIVEP3 MAST4 ATN1 FAM120C NAB2	1.02e-04	186	57	5	3902_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A	HIVEP3 TSR1 DENND4B PARD3 CABIN1	1.13e-04	190	57	5	1306_DN
Drug	Denatonium benzoate [3734-33-6]; Down 200; 9uM; HL60; HT_HG-U133A	NECTIN2 PIDD1 PACS2 CABIN1 CEP164	1.16e-04	191	57	5	3123_DN
Drug	15(S)-15-methyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A	DUOX1 FAM120C PLEKHO2 NAB2 PIDD1	1.19e-04	192	57	5	7489_UP
Drug	Carisoprodol [78-44-4]; Up 200; 15.4uM; MCF7; HT_HG-U133A	HIVEP3 ATN1 PER3 TSR1 APOL2	1.22e-04	193	57	5	3251_UP
Drug	17-AAG; Down 200; 1uM; PC3; HT_HG-U133A	HIVEP3 COL4A6 FAM120C NAB2 PIDD1	1.22e-04	193	57	5	5919_DN
Drug	Butylparaben [94-26-8]; Down 200; 20.6uM; MCF7; HT_HG-U133A	PIDD1 CACNA1I PARD3 CABIN1 APOL2	1.22e-04	193	57	5	5608_DN
Drug	Biperiden hydrochloride [1235-82-1]; Down 200; 11.4uM; MCF7; HT_HG-U133A	HIVEP3 NAB2 APOL2 CEP164 AHNAK2	1.25e-04	194	57	5	3321_DN
Drug	Indomethacin [53-86-1]; Up 200; 11.2uM; HL60; HT_HG-U133A	PIDD1 DGKG APOL2 CEP164 ZNF646	1.25e-04	194	57	5	2377_UP
Drug	Isradipine [75695-93-1]; Down 200; 10.8uM; PC3; HT_HG-U133A	HIVEP3 IGF1R ACTR5 CABIN1 CEP164	1.25e-04	194	57	5	6347_DN
Drug	Etidronic acid, disodium salt [7414-83-7]; Down 200; 16uM; MCF7; HT_HG-U133A	ATN1 FAM120C LTBP1 CABIN1 AHNAK2	1.25e-04	194	57	5	4387_DN
Drug	Sertaconazole nitrate [99592-39-9]; Down 200; 8uM; MCF7; HT_HG-U133A	MAST4 PLEKHO2 NAB2 PARD3 CEP164	1.25e-04	194	57	5	6811_DN
Drug	Ethambutol dihydrochloride [1070-11-7]; Down 200; 14.4uM; PC3; HT_HG-U133A	ATN1 NAB2 CABIN1 APOL2 SH2B1	1.25e-04	194	57	5	4001_DN
Drug	Acebutolol hydrochloride [34381-68-5]; Up 200; 10.8uM; PC3; HG-U133A	HIVEP3 ACTR5 PLEKHO2 NAB2 PARD3	1.28e-04	195	57	5	1911_UP
Drug	Mephenytoin [50-12-4]; Down 200; 18.4uM; MCF7; HT_HG-U133A	HIVEP3 MAST4 ATN1 PIDD1 CABIN1	1.28e-04	195	57	5	3580_DN
Drug	Ricinine [524-40-3]; Down 200; 24.4uM; MCF7; HT_HG-U133A	PER3 TMEM158 NAB2 PIDD1 CEP164	1.28e-04	195	57	5	6067_DN
Drug	Clioquinol [130-26-7]; Down 200; 13uM; HL60; HT_HG-U133A	HIVEP3 FES PIDD1 PACS2 PARD3	1.28e-04	195	57	5	3084_DN
Drug	Pralidoxime chloride [51-15-0]; Down 200; 23.2uM; PC3; HT_HG-U133A	HIVEP3 MAST4 ACTR5 PLEKHO2 APOL2	1.28e-04	195	57	5	6283_DN
Drug	Levopropoxyphene napsylate [5714-90-9]; Up 200; 7.4uM; MCF7; HT_HG-U133A	PER3 TSR1 NAB2 PIDD1 CACNA1I	1.28e-04	195	57	5	3543_UP
Drug	chlorpromazine hydrochloride; Up 200; 1uM; MCF7; HT_HG-U133A	HIVEP3 MAST4 ACTR5 PIDD1 CEP164	1.28e-04	195	57	5	6977_UP
Drug	Ben 101	CYP2D7 CYP2D6	1.28e-04	7	57	2	CID000090766
Drug	azoprocarbazine	CYP2D7 CYP2D6	1.28e-04	7	57	2	CID000075230
Drug	quinidine-N-oxide	CYP2D7 CYP2D6	1.28e-04	7	57	2	CID000050979
Drug	2-sulfamoylacetylphenol	CYP2D7 CYP2D6	1.28e-04	7	57	2	CID000194588
Drug	phenyl isocyanide	CYP2D7 CYP2D6	1.28e-04	7	57	2	CID000013606
Drug	ICI-199,441	CYP2D7 CYP2D6	1.28e-04	7	57	2	CID003082717
Drug	5,6-Dehydro-sparteine	CYP2D7 CYP2D6	1.28e-04	7	57	2	CID000523578
Drug	Dihydroergotoxine mesylate [8067-24-1]; Up 200; 6.4uM; MCF7; HT_HG-U133A	FAM120C TMEM158 NAB2 CACNA1I CABIN1	1.31e-04	196	57	5	2793_UP
Drug	Naltrexone hydrochloride dihydrate [16676-29-2]; Up 200; 9.6uM; PC3; HT_HG-U133A	IGF1R NAB2 CACNA1I APOL2 ST6GALNAC2	1.31e-04	196	57	5	2047_UP
Drug	PHA-00745360 [351320-33-7]; Up 200; 10uM; MCF7; HT_HG-U133A	COL4A6 DYRK1B CACNA1I PCDH12 ZNF646	1.31e-04	196	57	5	3907_UP
Drug	6-Hydroxytropinone [5932-53-6]; Up 200; 25.8uM; MCF7; HT_HG-U133A	ATN1 TMEM158 PACS2 CABIN1 CEP164	1.31e-04	196	57	5	4833_UP
Drug	Benserazide hydrochloride [14919-77-8]; Up 200; 13.6uM; MCF7; HT_HG-U133A	PLEKHO2 PIDD1 PCDH12 CABIN1 APOL2	1.31e-04	196	57	5	5322_UP
Drug	Tridihexethyl chloride; Up 200; 11.4uM; MCF7; HT_HG-U133A	COL4A6 ACTR5 FAM120C NAB2 CEP164	1.31e-04	196	57	5	5486_UP
Drug	Pyrantel tartrate [33401-94-4]; Up 200; 11.2uM; PC3; HT_HG-U133A	MAST4 MYO15A CABIN1 CEP164 SH2B1	1.31e-04	196	57	5	2097_UP
Drug	Chlorhexidine [55-56-1]; Up 200; 8uM; MCF7; HT_HG-U133A	PLEKHO2 TMEM158 CACNA1I PARD3 CEP164	1.34e-04	197	57	5	5403_UP
Drug	Deltaline [6836-11-9]; Down 200; 7.8uM; MCF7; HT_HG-U133A	PLEKHO2 PIDD1 CABIN1 APOL2 CEP164	1.34e-04	197	57	5	3831_DN
Drug	Trimethoprim [738-70-5]; Down 200; 13.8uM; MCF7; HT_HG-U133A	PLEKHO2 NAB2 CABIN1 CEP164 SH2B1	1.34e-04	197	57	5	2307_DN
Drug	PNU-0293363 [326823-19-2]; Up 200; 10uM; PC3; HT_HG-U133A	PIDD1 PARD3 CABIN1 APOL2 CEP164	1.34e-04	197	57	5	6563_UP
Drug	Triprolidine hydrochloride [550-70-9]; Down 200; 12.8uM; PC3; HT_HG-U133A	COL4A6 MAST4 NAB2 APOL2 ST6GALNAC2	1.34e-04	197	57	5	7248_DN
Drug	Rauwolscine hydrochloride [6211-32-1]; Down 200; 10.2uM; PC3; HT_HG-U133A	IGF1R MAST4 PIDD1 APOL2 ST6GALNAC2	1.34e-04	197	57	5	5800_DN
Drug	beta- Belladonnine dichloroethylate [191355-47-2]; Up 200; 6uM; MCF7; HT_HG-U133A	HIVEP3 PIDD1 CACNA1I CABIN1 CEP164	1.34e-04	197	57	5	2819_UP
Drug	Sulfamethoxypyridazine [80-35-3]; Down 200; 14.2uM; PC3; HT_HG-U133A	COL4A6 FAM120C NAB2 PIDD1 ST6GALNAC2	1.37e-04	198	57	5	3711_DN
Drug	(-)-Adenosine 3',5'-cyclic monophosphate [60-92-4]; Down 200; 12.2uM; HL60; HT_HG-U133A	HIVEP3 PIDD1 PACS2 APOL2 SH2B1	1.37e-04	198	57	5	2969_DN
Drug	(-)-Adenosine 3',5'-cyclic monophosphate [60-92-4]; Up 200; 12.2uM; PC3; HT_HG-U133A	ATN1 FAM120C PLEKHO2 NAB2 PIDD1	1.37e-04	198	57	5	5108_UP
Drug	Adrenosterone [382-45-6]; Down 200; 13.4uM; HL60; HT_HG-U133A	NAB2 NECTIN2 FES DGKG PARD3	1.37e-04	198	57	5	3107_DN
Drug	Glimepiride [93479-97-1]; Up 200; 8.2uM; HL60; HT_HG-U133A	NAB2 NECTIN2 CACNA1I LTBP1 CEP164	1.37e-04	198	57	5	2154_UP
Drug	Proparacaine hydrochloride [5875-06-9]; Down 200; 12uM; PC3; HT_HG-U133A	HIVEP3 IGF1R ACTR5 DENND4B PACS2	1.37e-04	198	57	5	6332_DN
Drug	Thiethylperazine malate [52239-63-1]; Up 200; 6uM; HL60; HT_HG-U133A	ATN1 PER3 DGKG PARD3 CEP164	1.37e-04	198	57	5	6154_UP
Drug	Benfotiamine [22457-89-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A	MAST4 ACTR5 PLEKHO2 PARD3 CABIN1	1.37e-04	198	57	5	6032_DN
Drug	Chlorthalidone [77-36-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	HIVEP3 MAST4 PLEKHO2 PARD3 SH2B1	1.37e-04	198	57	5	3198_DN
Drug	Ranitidine hydrochloride [66357-59-3]; Down 200; 11.4uM; MCF7; HT_HG-U133A	NAB2 PIDD1 CABIN1 APOL2 AHNAK2	1.37e-04	198	57	5	2251_DN
Drug	Cyclacillin [3485-14-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	MAST4 ATN1 FAM120C PARD3 AHNAK2	1.37e-04	198	57	5	3882_DN
Drug	Estrone [53-16-7]; Down 200; 14.8uM; MCF7; HT_HG-U133A	HIVEP3 PER3 ACTR5 CACNA1I CABIN1	1.40e-04	199	57	5	6448_DN
Drug	Ondansetron Hydrochloride [103639-04-9]; Up 200; 12.2uM; HL60; HT_HG-U133A	RARB ATN1 PER3 FAM120C CACNA1I	1.40e-04	199	57	5	6153_UP
Drug	Pizotifen malate [5189-11-7]; Down 200; 9.4uM; MCF7; HT_HG-U133A	HIVEP3 MAST4 ACTR5 PLEKHO2 NAB2	1.40e-04	199	57	5	6513_DN
Drug	Cotinine (-) [486-56-6]; Up 200; 22.6uM; MCF7; HT_HG-U133A	HIVEP3 FAM120C DGKG CACNA1I LTBP1	1.40e-04	199	57	5	1511_UP
Drug	Ketanserin tartrate hydrate [83846-83-7]; Up 200; 7uM; MCF7; HT_HG-U133A	HIVEP3 MAST4 ATN1 PARD3 CEP164	1.40e-04	199	57	5	4995_UP
Drug	Piroxicam [36322-90-4]; Down 200; 12uM; MCF7; HT_HG-U133A	HIVEP3 PER3 FAM120C PLEKHO2 CABIN1	1.40e-04	199	57	5	2252_DN
Drug	Methapyrilene hydrochloride [135-23-9]; Up 200; 13.4uM; MCF7; HT_HG-U133A	HIVEP3 TMEM158 CACNA1I PARD3 AHNAK2	1.40e-04	199	57	5	4990_UP
Drug	Piperacetazine [3819-00-9]; Down 200; 9.8uM; HL60; HT_HG-U133A	HIVEP3 ACTR5 PIDD1 CEP164 SH2B1	1.40e-04	199	57	5	6152_DN
Drug	Trimethoprim [738-70-5]; Down 200; 13.8uM; PC3; HT_HG-U133A	COL4A6 FAM120C NAB2 PARD3 CEP164	1.40e-04	199	57	5	3678_DN
Drug	Anabasine [494-52-0]; Down 200; 24.6uM; MCF7; HT_HG-U133A	MAST4 PER3 PLEKHO2 NAB2 CEP164	1.40e-04	199	57	5	6074_DN
Drug	Trimetazidine dihydrochloride [13171-25-0]; Up 200; 11.8uM; HL60; HG-U133A	HIVEP3 NAB2 FES CACNA1I PARD3	1.40e-04	199	57	5	1727_UP
Disease	solanidine measurement	CYP2D7 CYP2D6	2.19e-05	4	57	2	EFO_0800966
Disease	FEV/FEC ratio	HIVEP3 PRR12 RARB PLEKHO2 DGKG LTBP1 MYO15A PARD3 DTHD1 TNXB	1.09e-04	1228	57	10	EFO_0004713
Disease	Global developmental delay	PRR12 IGF1R ATN1 PACS2	1.29e-04	133	57	4	C0557874
Disease	taurolithocholate 3-sulfate measurement	IGF1R RARB	2.82e-04	13	57	2	EFO_0021036
Disease	schizophrenia (is_implicated_in)	ATN1 CACNA1I APOL2	4.69e-04	78	57	3	DOID:5419 (is_implicated_in)
Disease	sex interaction measurement, ulcerative colitis	TNXB SH2B1	4.89e-04	17	57	2	EFO_0000729, EFO_0008343
Disease	macula measurement	RARB KANSL1 LRP11 DYRK1B	4.94e-04	189	57	4	EFO_0008375
Disease	Parkinson Disease	IGF1R CYP2D6 NECTIN2	6.03e-04	85	57	3	C0030567
Disease	skin sensitivity to sun	RXFP3 PARD3	6.14e-04	19	57	2	EFO_0004795
Disease	cognitive function measurement, self reported educational attainment	PRR12 KANSL1 CACNA1I TNXB SH2B1	6.14e-04	355	57	5	EFO_0004784, EFO_0008354
Disease	risk-taking behaviour	HIVEP3 RMI1 IGF1R RARB TSR1 TNXB SH2B1	6.52e-04	764	57	7	EFO_0008579
Disease	Acute Confusional Senile Dementia	IGF1R CYP2D6 NECTIN2	9.40e-04	99	57	3	C0546126
Disease	Alzheimer's Disease, Focal Onset	IGF1R CYP2D6 NECTIN2	9.40e-04	99	57	3	C0750900
Disease	Alzheimer Disease, Early Onset	IGF1R CYP2D6 NECTIN2	9.40e-04	99	57	3	C0750901
Disease	Presenile dementia	IGF1R CYP2D6 NECTIN2	9.40e-04	99	57	3	C0011265
Disease	Alzheimer Disease, Late Onset	IGF1R CYP2D6 NECTIN2	9.40e-04	99	57	3	C0494463
Disease	Familial Alzheimer Disease (FAD)	IGF1R CYP2D6 NECTIN2	9.68e-04	100	57	3	C0276496
Disease	unipolar depression, response to selective serotonin reuptake inhibitor	CYP2D7 CYP2D6	9.85e-04	24	57	2	EFO_0003761, EFO_0005658
Disease	Alzheimer's Disease	IGF1R CYP2D6 NECTIN2	9.96e-04	101	57	3	C0002395
Disease	brain connectivity measurement	CYP2D7 CYP2D6 KANSL1 TMEM158 FES	1.05e-03	400	57	5	EFO_0005210
Disease	urinary metabolite measurement	CYP2D7 CYP2D6 HDAC10 CABIN1	1.30e-03	245	57	4	EFO_0005116
Disease	glucose metabolism disease (implicated_via_orthology)	IGF1R DGKG	1.34e-03	28	57	2	DOID:4194 (implicated_via_orthology)
Disease	physical activity measurement, body mass index	RARB DGKG SH2B1	1.41e-03	114	57	3	EFO_0004340, EFO_0008002
Disease	migraine disorder, glucose measurement	RMI1 IGF1R	1.64e-03	31	57	2	EFO_0004468, MONDO_0005277
Disease	Intellectual Disability	PRR12 KANSL1 ATN1 PACS2 PCDH12	1.71e-03	447	57	5	C3714756
Disease	Squamous cell carcinoma of lung	IGF1R MAST4	1.75e-03	32	57	2	C0149782
Disease	puberty onset measurement	RMI1 IGF1R KANSL1	1.84e-03	125	57	3	EFO_0005677
Disease	intracranial volume measurement	KANSL1 APOL2	1.86e-03	33	57	2	EFO_0004886

Protein segments in the cluster

Peptide	Gene	Start	Entry
PGAVVLVGGLSPPVH	AKAP2	81	Q9Y2D5
PPPHVIGRISAEGGE	APOL2	241	Q9BQE5
KGEPGSPGLVHLPEL	COL4A6	696	Q14031
LGLLHPVDPIVGEPG	BRD7	351	Q9NPI1
PPIHLGHLPLQEGEL	AMBN	146	Q9NP70
ELEPLHGVPGPGLDP	ATN1	956	P54259
LTHLPGPKEPGELAG	HTR3C	376	Q8WXA8
DPVLEAGPVAHGPLP	ACTR5	16	Q9H9F9
AGPVAHGPLPVPLVL	ACTR5	21	Q9H9F9
PDDPATLGPHLGLRG	DYRK1B	606	Q9Y463
PVIGGLSLPPLHGLH	RARB	31	P10826
GHLLVPIETPNGLGP	PCDH12	586	Q9NPG4
LLPGGLLESHRDPGP	DUOX1	481	Q9NRD9
HLPLVLGPLGGAPTV	MBD6	296	Q96DN6
GGEHPAPETGAVLPL	LRP11	441	Q86VZ4
GDIIHLQPLEPPRVG	MYO15A	2891	Q9UKN7
KGSRLHPEELGGPPL	NAB2	361	Q15742
LPPNKDVEPGILLHG	IGF1R	556	P08069
PEGLHGLPLSEGLQP	PER3	821	P56645
VVHPGPGLAAGALPL	LTBP1	31	Q14766
NKGLIVLGEVPPPEH	KANSL1	476	Q7Z3B3
PDRAGIHGPPLIIEG	LY75	806	O60449
DTVALGVPGPREHPG	PACS2	371	Q86VP3
PEGVDILITHGPPLG	MPPED1	236	O15442
HPPVAVLPLGTGNDL	DGKG	511	P49619
QPDLVLVALGPGHGL	HDAC10	571	Q969S8
PLHSPGLLETGAPVG	CABIN1	351	Q9Y6J0
GPLPLPGLGNLLHVD	CYP2D6	36	P10635
ELEMAHGLGPGPRLP	CACNA1I	1751	Q9P0X4
AGLHPIPPQGGKLEI	FAM120C	946	Q9NX05
LKDLHLEGFGGPPEP	DTHD1	536	Q6ZMT9
GGRPLEVLEKPVHLP	MAST4	2291	O15021
HKAVGLLLETLGPPP	DENND4B	1406	O75064
TPVLDPHGAPLGIIF	MFSD5	271	Q6N075
LLPEPGLVPLGPHDA	PIDD1	361	Q9HB75
EVPNDGGPLGIHVVP	PARD3	276	Q8TEW0
TKLEHLGPGEPPPVL	FES	386	P07332
ELGLELPDGAPPGHP	RXFP3	51	Q9NSD7
IPIEEGPPTGTVHPL	SH2B1	476	Q9NRF2
LGHVVVAPPGAPGLV	SPATA5L1	146	Q9BVQ7
VAPPGAPGLVAALHI	SPATA5L1	151	Q9BVQ7
HPLLPDGILEIPKGE	RMI1	66	Q9H9A7
GPGPAKLPHSVLLEI	PSAT1	11	Q9Y617
GVPVPEGLDKGDRPH	ST6GALNAC2	246	Q9UJ37
PTPHGLLLEAGGPDL	PRR12	776	Q9ULL5
THIHLAPGLPGDPGI	TRPT1	151	Q86TN4
HSGPAAEILPGPLEG	TET1	206	Q8NFU7
VHLGTLIGLNPVGPE	BPIFB2	186	Q8N4F0
LPEGPVPEGASLKGH	AHNAK2	4036	Q8IVF2
SLAPVHVPLGGLAPL	CEP164	136	Q9UPV0
GPLPLPGLGNLLHVD	CYP2D7	36	A0A087X1C5
GAVPVPLLGAHPLLL	ZNF865	516	P0CJ78
GGKDGPPHQVLVVPL	TSR1	76	Q2NL82
GPPLLIEHLGLAAGG	TMEM158	121	Q8WZ71
RVPEGPGAHEEVLPG	TNXB	996	P22105
EHGPGLGLDPRVLFP	HIVEP3	2101	Q5T1R4
GGAEPVPHLEDGVPR	ZNF646	1421	O15015
GIAEAVGLPSIPVHP	nan	476	Q3C1V9
LGDLLGEGPRHPLQP	PLEKHO2	391	Q8TD55
GGPEVILRPPVVHVD	USP33	911	Q8TEY7
PILILLLGTGHGPGV	TM9SF1	16	O15321
LGGTVELPCHLLPPV	NECTIN2	46	Q92692