Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cyclin-dependent protein kinase activity	CDK8 CDK19	4.95e-04	30	22	2	GO:0097472
GeneOntologyMolecularFunction	cyclin-dependent protein serine/threonine kinase activity	CDK8 CDK19	4.95e-04	30	22	2	GO:0004693
GeneOntologyMolecularFunction	protein serine kinase activity	CDK8 MAST2 MAST3 CDK19	6.06e-04	363	22	4	GO:0106310
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	CDK8 MAST2 MAST3 CDK19	1.31e-03	446	22	4	GO:0004674
GeneOntologyMolecularFunction	protein kinase activity	CDK8 MAST2 MAST3 CDK19	3.84e-03	600	22	4	GO:0004672
GeneOntologyCellularComponent	CKM complex	CDK8 CDK19	9.59e-06	5	21	2	GO:1990508
GeneOntologyCellularComponent	nuclear cyclin-dependent protein kinase holoenzyme complex	CDK8 CDK19	1.46e-04	18	21	2	GO:0019908
GeneOntologyCellularComponent	neuronal dense core vesicle	DMXL2 VPS13A	5.93e-04	36	21	2	GO:0098992
GeneOntologyCellularComponent	exocytic vesicle membrane	PTPRN2 DMXL2 UNC13C	7.33e-04	179	21	3	GO:0099501
GeneOntologyCellularComponent	synaptic vesicle membrane	PTPRN2 DMXL2 UNC13C	7.33e-04	179	21	3	GO:0030672
GeneOntologyCellularComponent	dense core granule	DMXL2 VPS13A	1.43e-03	56	21	2	GO:0031045
GeneOntologyCellularComponent	cyclin-dependent protein kinase holoenzyme complex	CDK8 CDK19	1.70e-03	61	21	2	GO:0000307
GeneOntologyCellularComponent	transport vesicle membrane	PTPRN2 DMXL2 UNC13C	3.01e-03	293	21	3	GO:0030658
GeneOntologyCellularComponent	synaptic vesicle	PTPRN2 DMXL2 UNC13C	3.21e-03	300	21	3	GO:0008021
GeneOntologyCellularComponent	exocytic vesicle	PTPRN2 DMXL2 UNC13C	3.85e-03	320	21	3	GO:0070382
GeneOntologyCellularComponent	terminal bouton	PTPRN2 UNC13C	4.14e-03	96	21	2	GO:0043195
Domain	DUF1908	MAST2 MAST3	7.94e-06	4	22	2	PF08926
Domain	MA_Ser/Thr_Kinase_dom	MAST2 MAST3	7.94e-06	4	22	2	IPR015022
Domain	MAST_pre-PK_dom	MAST2 MAST3	7.94e-06	4	22	2	IPR023142
Domain	-	MAST2 MAST3	7.94e-06	4	22	2	1.20.1480.20
Domain	PDZ	MAST2 RADIL MAST3	5.84e-04	141	22	3	PF00595
Domain	PDZ	MAST2 RADIL MAST3	6.72e-04	148	22	3	SM00228
Domain	-	MAST2 RADIL MAST3	6.99e-04	150	22	3	2.30.42.10
Domain	PDZ	MAST2 RADIL MAST3	7.13e-04	151	22	3	PS50106
Domain	PDZ	MAST2 RADIL MAST3	7.26e-04	152	22	3	IPR001478
Domain	Ser/Thr_kinase_AS	CDK8 MAST2 MAST3 CDK19	7.31e-04	357	22	4	IPR008271
Domain	S_TKc	CDK8 MAST2 MAST3 CDK19	7.47e-04	359	22	4	SM00220
Domain	PROTEIN_KINASE_ST	CDK8 MAST2 MAST3 CDK19	7.70e-04	362	22	4	PS00108
Domain	Pkinase	CDK8 MAST2 MAST3 CDK19	9.32e-04	381	22	4	PF00069
Domain	Pkinase_C	MAST2 MAST3	1.11e-03	42	22	2	PF00433
Domain	PROTEIN_KINASE_ATP	CDK8 MAST2 MAST3 CDK19	1.85e-03	459	22	4	PS00107
Domain	AGC-kinase_C	MAST2 MAST3	1.96e-03	56	22	2	IPR000961
Domain	AGC_KINASE_CTER	MAST2 MAST3	1.96e-03	56	22	2	PS51285
Domain	S_TK_X	MAST2 MAST3	1.96e-03	56	22	2	SM00133
Domain	Prot_kinase_dom	CDK8 MAST2 MAST3 CDK19	2.33e-03	489	22	4	IPR000719
Domain	PROTEIN_KINASE_DOM	CDK8 MAST2 MAST3 CDK19	2.40e-03	493	22	4	PS50011
Domain	Kinase-like_dom	CDK8 MAST2 MAST3 CDK19	3.38e-03	542	22	4	IPR011009
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION	CDK8 CDK19	1.53e-03	84	10	2	M1008
Pathway	REACTOME_RSV_HOST_INTERACTIONS	CDK8 CDK19	2.08e-03	98	10	2	M48247
Pathway	REACTOME_ADIPOGENESIS	CDK8 CDK19	2.61e-03	110	10	2	M48259
Pathway	WP_5Q35_COPY_NUMBER_VARIATION	PTPRN2 UNC5A	2.65e-03	111	10	2	M48089
Pathway	REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA	CDK8 CDK19	2.99e-03	118	10	2	M27316
Pathway	REACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_INFECTION_PATHWAY	CDK8 CDK19	3.09e-03	120	10	2	M48233
Pubmed	[Mechanisms of transcriptional regulation upon protein phosphorylation by mediator complexes].	CDK8 CDK19	3.82e-07	2	22	2	20408451
Pubmed	Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer.	CDK8 CDK19	3.82e-07	2	22	2	35181333
Pubmed	CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins.	CDK8 CDK19	3.82e-07	2	22	2	37378433
Pubmed	Regulatory functions of the Mediator kinases CDK8 and CDK19.	CDK8 CDK19	3.82e-07	2	22	2	30585107
Pubmed	Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer.	CDK8 CDK19	3.82e-07	2	22	2	27678455
Pubmed	Mediator kinase inhibition further activates super-enhancer-associated genes in AML.	CDK8 CDK19	3.82e-07	2	22	2	26416749
Pubmed	HIV Transcription Is Independent of Mediator Kinases.	CDK8 CDK19	3.82e-07	2	22	2	31044597
Pubmed	Identification of target genes for the CDK subunits of the Mediator complex.	CDK8 CDK19	3.82e-07	2	22	2	22117896
Pubmed	CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.	CDK8 CDK19	3.82e-07	2	22	2	36006697
Pubmed	Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection.	CDK8 CDK19	3.82e-07	2	22	2	32560467
Pubmed	CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.	CDK8 CDK19	3.82e-07	2	22	2	28855340
Pubmed	Mediator complex cooperatively regulates transcription of retinoic acid target genes with Polycomb Repressive Complex 2 during neuronal differentiation.	CDK8 CDK19	1.15e-06	3	22	2	26002960
Pubmed	Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.	CDK8 CDK19	1.15e-06	3	22	2	28151579
Pubmed	Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.	CDK8 CDK19	2.29e-06	4	22	2	29440396
Pubmed	Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases.	MAST2 MAST3	2.29e-06	4	22	2	15951562
Pubmed	Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development.	CDK8 CDK19	2.29e-06	4	22	2	32439758
Pubmed	CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.	CDK8 CDK19	3.82e-06	5	22	2	36545778
Pubmed	Mediator CDK subunits are platforms for interactions with various chromatin regulatory complexes.	CDK8 CDK19	8.01e-06	7	22	2	22668559
Pubmed	Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes.	CDK8 CDK19	1.07e-05	8	22	2	23749998
Pubmed	Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients.	PTPRN2 JMY	1.07e-05	8	22	2	18398821
Pubmed	The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7.	CDK8 CDK19	1.07e-05	8	22	2	30695077
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ABCA8 DMXL2 RADIL MAST3 DOP1A	1.21e-05	493	22	5	15368895
Pubmed	Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.	CDK8 SAP30	1.37e-05	9	22	2	9150135
Pubmed	A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction.	CDK8 CDK19	2.51e-05	12	22	2	23563140
Pubmed	Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations.	MAST2 MAST3	6.49e-05	19	22	2	30449657
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	MAST2 PTPRN2 MAST3	7.46e-05	130	22	3	12421765
Pubmed	Host PDZ-containing proteins targeted by SARS-CoV-2.	MAST2 RADIL	2.24e-04	35	22	2	33864728
Pubmed	A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.	CDK8 CDK19	4.06e-04	47	22	2	15175163
Cytoband	Ensembl 112 genes in cytogenetic band chr15q21	DMXL2 SPG11 UNC13C	8.22e-05	177	22	3	chr15q21
Cytoband	Ensembl 112 genes in cytogenetic band chr7p22	RADIL SNX8	1.88e-03	134	22	2	chr7p22
GeneFamily	Cyclin dependent kinases	CDK8 CDK19	2.36e-04	26	16	2	496
GeneFamily	PDZ domain containing	MAST2 RADIL MAST3	3.01e-04	152	16	3	1220
GeneFamily	Cyclins\|Mediator complex	CDK8 CDK19	3.82e-04	33	16	2	1061
Disease	developmental and epileptic encephalopathy 87 (implicated_via_orthology)	CDK8 CDK19	4.82e-07	2	21	2	DOID:0112221 (implicated_via_orthology)
Disease	Colorectal Carcinoma	PTPRN2 ABCA8 ACTL9 SNX8 VPS13A	1.11e-04	702	21	5	C0009402
Disease	mental or behavioural disorder	PTPRN2 SLC39A12 SNX8	2.69e-04	179	21	3	EFO_0000677
Disease	atopic eczema, psoriasis	PTPRN2 UNC13C	3.00e-04	36	21	2	EFO_0000274, EFO_0000676
Disease	wheezing	PTPRN2 SPG11	9.77e-04	65	21	2	EFO_0009715
Disease	reaction time measurement	PTPRN2 ENPP3 TMEM229A CDK19	1.08e-03	658	21	4	EFO_0008393
Disease	response to vaccine	CDK8 UNC13C	3.38e-03	122	21	2	EFO_0004645
Disease	coronary artery calcification	PTPRN2 DMXL2 ENPP3	3.82e-03	450	21	3	EFO_0004723
Disease	verbal-numerical reasoning measurement	PTPRN2 DMXL2	3.89e-03	131	21	2	EFO_0008394
Disease	Parkinson's disease (implicated_via_orthology)	PTPRN2 VPS13A	5.53e-03	157	21	2	DOID:14330 (implicated_via_orthology)
Disease	risky sexual behaviour measurement	PTPRN2 MAST3	6.38e-03	169	21	2	EFO_0007877
Disease	serum albumin measurement	ABCA8 SLC39A12 SNX8	8.17e-03	592	21	3	EFO_0004535
Disease	age at menarche	PTPRN2 UNC13C MAST3	8.24e-03	594	21	3	EFO_0004703
Disease	urate measurement, bone density	PTPRN2 ABCA8 TMEM229A	9.22e-03	619	21	3	EFO_0003923, EFO_0004531
Disease	triglycerides:total lipids ratio, high density lipoprotein cholesterol measurement	ABCA8 JMY	9.33e-03	206	21	2	EFO_0004612, EFO_0020947
Disease	C-reactive protein measurement	DMXL2 JMY SPG11 RADIL	9.53e-03	1206	21	4	EFO_0004458
Disease	fat body mass	UNC13C MAST3	1.03e-02	217	21	2	EFO_0005409
Disease	triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	ABCA8 SPG11	1.10e-02	225	21	2	EFO_0008317, EFO_0020947
Disease	amino acid measurement	CDK8 PTPRN2 UNC13C	1.18e-02	678	21	3	EFO_0005134

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLYQILDGIHYLHAN	CDK19	131	Q9BWU1
QDLDLVENIKHHYCY	ACTL9	246	Q8TC94
IHYCLLDPTTQYHQL	DOP1A	1731	Q5JWR5
NPVLYLNNHIHDILY	DMXL2	2221	Q8TDJ6
NLYHIYEVNLVSEHI	PTPRN2	866	Q92932
CLDDSIYQHLLYVRH	RADIL	791	Q96JH8
EIDTLCYQLQVYLGH	JMY	281	Q8N9B5
LQKNVDHCLLYHREY	ENPP3	616	O14638
LALEYLHNYGIVHRD	MAST2	621	Q6P0Q8
LALEYLHNYGIVHRD	MAST3	476	O60307
LLYQILDGIHYLHAN	CDK8	131	P49336
LLLLYYIIHQEEICS	SLC39A12	116	Q504Y0
YFSLYCLHQETQLIH	SNX8	391	Q9Y5X2
ALDLALQYVLALYHC	TMEM229A	156	B2RXF0
ARHLYICDYHKNLIQ	SAP30	106	O75446
LLCLYIYPHSHQVND	ABCA8	41	O94911
CLEHSLQHLLYVYLD	SPG11	996	Q96JI7
EYLLYGHHREQIACQ	ZBTB14	266	O43829
LINLHCQLELEVHYY	VPS13A	1761	Q96RL7
IQYTCLHENLFHYLT	UNC13C	1361	Q8NB66
ECVQYQHVLHRNLIY	SS18L2	46	Q9UHA2
LEYNIRVYCLHDTHD	UNC5A	606	Q6ZN44