Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ArfGap	AGAP5 AGAP11 AGAP9	7.48e-05	29	53	3	SM00105
Domain	ArfGap	AGAP5 AGAP11 AGAP9	7.48e-05	29	53	3	PF01412
Domain	ARFGAP	AGAP5 AGAP11 AGAP9	7.48e-05	29	53	3	PS50115
Domain	ArfGAP	AGAP5 AGAP11 AGAP9	7.48e-05	29	53	3	IPR001164
Domain	SEA	IMPG1 MUC16	7.03e-04	14	53	2	SM00200
Domain	ANK_REP_REGION	AGAP5 MUC16 AGAP11 AGAP9 NOTCH2	7.54e-04	254	53	5	PS50297
Domain	-	IMPG1 MUC16	8.10e-04	15	53	2	3.30.70.960
Domain	SEA	IMPG1 MUC16	1.76e-03	22	53	2	PF01390
Domain	SEA	IMPG1 MUC16	1.92e-03	23	53	2	PS50024
Domain	SEA_dom	IMPG1 MUC16	1.92e-03	23	53	2	IPR000082
Domain	TUDOR	TDRKH KDM4C	1.92e-03	23	53	2	PS50304
Domain	TUDOR	TDRKH KDM4C	2.65e-03	27	53	2	SM00333
Domain	ENTH_VHS	EPN3 TTI1	3.05e-03	29	53	2	IPR008942
Domain	Tudor	TDRKH KDM4C	3.27e-03	30	53	2	IPR002999
Domain	-	AGAP5 AGAP11 AGAP9 NOTCH2	5.34e-03	248	53	4	1.25.40.20
Domain	ANK_REPEAT	AGAP5 MUC16 AGAP11 NOTCH2	5.72e-03	253	53	4	PS50088
Domain	Ankyrin_rpt-contain_dom	AGAP5 AGAP11 AGAP9 NOTCH2	5.80e-03	254	53	4	IPR020683
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP5 AGAP11 AGAP9	3.12e-07	9	55	3	12640130
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP5 AGAP11 AGAP9	4.46e-07	10	55	3	20664521
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP5 AGAP11 AGAP9	6.12e-07	11	55	3	15381706
Pubmed	The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.	AGAP5 AGAP11 AGAP9	1.06e-06	13	55	3	27713690
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	AGAP5 MICALL2 TNRC6B AGAP11 AGAP9 PCM1	1.27e-06	218	55	6	33378226
Pubmed	GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.	AGAP5 AGAP11 AGAP9	1.35e-06	14	55	3	22453919
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	EYA4 BRCA2 TNRC6B WDR25 GARRE1	4.35e-06	152	55	5	38360978
Pubmed	ADAM10 and Notch1 on murine dendritic cells control the development of type 2 immunity and IgE production.	ADAM10 NOTCH2	1.47e-05	4	55	2	28745029
Pubmed	ADAM10 mediates ectopic proximal tubule development and renal fibrosis through Notch signalling.	ADAM10 NOTCH2	1.47e-05	4	55	2	32715474
Pubmed	Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine.	TIMD4 ADAM10	1.47e-05	4	55	2	24286866
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	AGAP5 WDCP TNRC6B TTI1 AGAP11 AGAP9 NOTCH2	2.13e-05	536	55	7	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	AGAP5 WDCP TNRC6B TTI1 AGAP11 AGAP9 NOTCH2	2.18e-05	538	55	7	10512203
Pubmed	TAO-kinase 3 governs the terminal differentiation of NOTCH2-dependent splenic conventional dendritic cells.	ADAM10 NOTCH2	2.45e-05	5	55	2	33214146
Pubmed	ADAM10-Notch signaling governs the recruitment of ovarian pregranulosa cells and controls folliculogenesis in mice.	ADAM10 NOTCH2	2.45e-05	5	55	2	27084580
Pubmed	ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo.	ADAM10 NOTCH2	2.45e-05	5	55	2	20156974
Pubmed	Identification of a novel Sry-related gene and its germ cell-specific expression.	UTP14A IL3	3.67e-05	6	55	2	10359848
Pubmed	Assessing Myf5 and Lbx1 contribution to carapace development by reproducing their turtle-specific signatures in mouse embryos.	MYF5 TBX5	8.78e-05	9	55	2	35618666
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	MYT1L AGAP5 STARD8 KDM4C CAPRIN2 SECISBP2 PRAMEF12 AGAP11 AGAP9	1.33e-04	1242	55	9	30973865
Pubmed	The bHLH regulator pMesogenin1 is required for maturation and segmentation of paraxial mesoderm.	MYF5 NOTCH2	1.60e-04	12	55	2	11124811
Pubmed	Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites.	FYCO1 PCM1	1.60e-04	12	55	2	24089205
Pubmed	Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints.	MYF5 NOTCH2	1.60e-04	12	55	2	17572911
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	AGAP5 CAPRIN2 AGAP11 AGAP9 GARRE1 KIAA1614	1.86e-04	529	55	6	14621295
Pubmed	Wnt signaling from the dorsal neural tube is required for the formation of the medial dermomyotome.	MYF5 NOTCH2	1.89e-04	13	55	2	9811581
Pubmed	Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation.	MYF5 NOTCH2	1.89e-04	13	55	2	18708576
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	UTP14A TNRC6B PCM1 NOTCH2	2.09e-04	184	55	4	32908313
Pubmed	Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants.	MYF5 NOTCH2	2.54e-04	15	55	2	17194759
Pubmed	New genetic associations detected in a host response study to hepatitis B vaccine.	TIMD4 SLITRK3 FYCO1 RO60 IL17RA PTGER3 IL3	3.08e-04	824	55	7	20237496
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	BRCA2 WDCP SECISBP2 GARRE1 PCM1 CDC7	3.27e-04	588	55	6	38580884
Pubmed	Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development.	ADAM10 NOTCH2	3.70e-04	18	55	2	14607778
Pubmed	The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.	ERAP1 IL3	5.06e-04	21	55	2	19578876
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	MYF5 BRCA2 KDM4C PRAMEF12 NOTCH2	5.54e-04	424	55	5	21731673
Pubmed	A single-cell time-lapse of mouse prenatal development from gastrula to birth.	MUC16 TBX5	7.20e-04	25	55	2	38355799
Pubmed	miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors.	MYF5 TBX5	7.79e-04	26	55	2	21708977
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	AGAP5 AGAP11 AGAP9	8.36e-04	116	55	3	30652415
Pubmed	YAP and TAZ are required for the postnatal development and the maintenance of the structural integrity of the oviduct.	MYF5 NOTCH2	9.70e-04	29	55	2	32520726
Pubmed	Baf60c is essential for function of BAF chromatin remodelling complexes in heart development.	MYF5 TBX5	9.70e-04	29	55	2	15525990
Pubmed	Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.	TDRKH ERAP1 CD109 RO60	1.04e-03	282	55	4	35007762
Pubmed	Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication.	MYF5 TBX5	1.26e-03	33	55	2	24705356
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	TDRKH UTP14A MUC16 TNRC6B PCM1 NOTCH2	1.39e-03	777	55	6	35844135
Cytoband	14q32.12	FAM181A UNC79	5.60e-04	29	55	2	14q32.12
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP5 AGAP11 AGAP9	5.26e-06	17	37	3	1291
GeneFamily	ArfGAPs	AGAP5 AGAP11 AGAP9	4.13e-05	33	37	3	395
GeneFamily	Ankyrin repeat domain containing	AGAP5 AGAP11 AGAP9 NOTCH2	1.46e-03	242	37	4	403
GeneFamily	Tudor domain containing	TDRKH KDM4C	2.59e-03	37	37	2	780
Coexpression	KARLSSON_TGFB1_TARGETS_DN	AGAP5 CST3 TNRC6B AGAP11 AGAP9 ADAM10	4.49e-06	209	54	6	MM1058
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_200	ZYG11A TDRKH BRCA2 MEIOC CAPRIN2	2.86e-05	143	53	5	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_200
ToppCell	Entopeduncular-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Htra1_(Htra1)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	EYA4 CD109 MYOM3 FAM181A	1.45e-06	67	55	4	8502da9042f40e0a44354776bb507e18ef0cda43
ToppCell	Entopeduncular-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Htra1_(Htra1)--\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	EYA4 CD109 MYOM3 FAM181A	1.45e-06	67	55	4	e6d051404f095ab9ca95fa6e5ecf0905573a5a63
ToppCell	Entopeduncular-Macroglia-ASTROCYTE-Gja1-Astrocyte.Gja1.Htra1_(Htra1)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	EYA4 CD109 MYOM3 FAM181A	1.45e-06	67	55	4	3a3a3e76f67c1d33bd7b1d0d94c522ad1e1192f8
ToppCell	Tracheal-10x3prime_v2-Immune_Lymphocytic-T-T_CD4-T_reg\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ZYG11A TDRKH TIMD4 OTUD7A ADGRF3	4.35e-06	196	55	5	6362fb0b5dc923f19a76b605d7289a16f89220e3
Drug	Glibenclamide [10238-21-8]; Down 200; 8uM; MCF7; HT_HG-U133A	TDRKH WDCP CAPRIN2 UTP14A TNRC6B IL17RA ADAM10	3.82e-07	195	54	7	3163_DN
Drug	Dimethisoquin hydrochloride [2773-92-4]; Down 200; 13uM; MCF7; HT_HG-U133A	MICALL2 ERAP1 WDCP UTP14A TNRC6B RO60 WDR25	4.24e-07	198	54	7	4791_DN
Drug	Tyloxapol [25301-02-4]; Down 200; 4uM; MCF7; HT_HG-U133A	BRCA2 KDM4C UTP14A RO60 ADAM10 PCM1	7.32e-06	198	54	6	6452_DN
Drug	Evoxine [522-11-2]; Up 200; 11.6uM; PC3; HT_HG-U133A	ERAP1 PRAMEF12 WDR25 PTGER3 PCM1 NOTCH2	7.32e-06	198	54	6	7380_UP
Drug	SR-95639A [115767-94-7]; Down 200; 10uM; PC3; HT_HG-U133A	TDRKH EYA4 MICALL2 CTC1 WDR25 PTGER3	7.53e-06	199	54	6	6632_DN
Drug	Succimer	EYA4 BRCA2 MICALL2 ERAP1 KDM4C CD109 CST3 TNRC6B FYCO1 RO60 PCM1 CDC7	3.18e-05	1264	54	12	ctd:D004113
Drug	Magnetite Nanoparticles	EYA4 BRCA2 MICALL2 ERAP1 KDM4C CD109 CST3 TNRC6B FYCO1 RO60 PCM1 CDC7	4.51e-05	1310	54	12	ctd:D058185
Drug	Fluphenazine dihydrochloride [146-56-5]; Down 200; 7.8uM; MCF7; HT_HG-U133A	CTC1 WDCP IL17RA WDR25 GARRE1	9.61e-05	194	54	5	3194_DN
Drug	Dioxybenzone [131-53-3]; Up 200; 16.4uM; MCF7; HT_HG-U133A	IMPG1 UTP14A PRAMEF12 GARRE1 TBX5	9.61e-05	194	54	5	5699_UP
Drug	Prazosin hydrochloride [19237-84-4]; Down 200; 9.6uM; PC3; HT_HG-U133A	EYA4 MICALL2 ERAP1 TNRC6B IL17RA	1.01e-04	196	54	5	6315_DN
Drug	Oxprenolol hydrochloride [6452-73-9]; Up 200; 13.2uM; MCF7; HT_HG-U133A	ERAP1 CAPRIN2 PRAMEF12 GARRE1 PCM1	1.01e-04	196	54	5	7225_UP
Drug	S-(+)-ibuprofen [51146-56-6]; Down 200; 19.4uM; MCF7; HT_HG-U133A	KDM4C CAPRIN2 UTP14A RO60 IL17RA	1.01e-04	196	54	5	6471_DN
Drug	Ethisterone [434-03-7]; Up 200; 12.8uM; HL60; HT_HG-U133A	MICALL2 ERAP1 KDM4C CAPRIN2 PTGER3	1.03e-04	197	54	5	2366_UP
Drug	Lomefloxacin hydrochloride [98079-52-8]; Down 200; 10.4uM; PC3; HT_HG-U133A	ERAP1 UTP14A RO60 ADAM10 NOTCH2	1.03e-04	197	54	5	3723_DN
Drug	Clenbuterol hydrochloride [21898-19-1]; Down 200; 12.8uM; MCF7; HT_HG-U133A	KDM4C UTP14A RO60 IL17RA TBX5	1.03e-04	197	54	5	3228_DN
Drug	aspirin, USP; Up 200; 100uM; PC3; HT_HG-U133A	EYA4 BRCA2 KDM4C WDR25 PTGER3	1.03e-04	197	54	5	1204_UP
Drug	Prostaglandin E1; Up 200; 10uM; MCF7; HT_HG-U133A	BRCA2 ERAP1 GATAD1 WDR25 GARRE1	1.03e-04	197	54	5	6576_UP
Drug	Indomethacin [53-86-1]; Down 200; 11.2uM; MCF7; HT_HG-U133A	TDRKH GATAD1 RO60 IL17RA NOTCH2	1.03e-04	197	54	5	5468_DN
Drug	Coralyne chloride hydrate [38989-38-7]; Down 200; 9.6uM; HL60; HT_HG-U133A	ERAP1 KDM4C WDCP TNRC6B ADAM10	1.06e-04	198	54	5	1298_DN
Drug	Zaprinast [37762-06-4]; Up 200; 14.8uM; PC3; HT_HG-U133A	EYA4 KDM4C UTP14A SECISBP2 PTGER3	1.06e-04	198	54	5	6749_UP
Drug	Pentamidine isethionate [140-64-7]; Up 200; 6.8uM; MCF7; HT_HG-U133A	TDRKH KDM4C RO60 GARRE1 TBX5	1.08e-04	199	54	5	2834_UP
Drug	Rilmenidine hemifumarate [54187-04-1]; Up 200; 8.4uM; MCF7; HT_HG-U133A	ERAP1 KDM4C UTP14A TNRC6B PTGER3	1.11e-04	200	54	5	5532_UP
Disease	cerebral palsy (implicated_via_orthology)	AGAP5 AGAP11 AGAP9	6.14e-07	10	52	3	DOID:1969 (implicated_via_orthology)
Disease	osteosarcoma (implicated_via_orthology)	BRCA2 IL3	1.82e-05	4	52	2	DOID:3347 (implicated_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	KDM4C ADGRF3 UNC79 NOTCH2	3.91e-04	195	52	4	DOID:1574 (implicated_via_orthology)
Disease	triglyceride measurement, intermediate density lipoprotein measurement	TIMD4 BRCA2 ADAM10	1.00e-03	111	52	3	EFO_0004530, EFO_0008595
Disease	Miller Dieker syndrome	BRCA2 CTC1	1.20e-03	29	52	2	C0265219
Disease	Abnormality of radial ray	BRCA2 TBX5	1.55e-03	33	52	2	C4228778

Protein segments in the cluster

Peptide	Gene	Start	Entry
SLSWMQSPDLESSKC	LINC00479	46	Q96M42
SCASKSMSEGIPWPS	ADGRF3	1056	Q8IZF5
ANTPTPICKQSMGWS	AGAP11	76	Q8TF27
TANTPTPVCKRSMRW	AGAP9	281	Q5VTM2
EPMTMFLWTLCTSPS	CTC1	1136	Q2NKJ3
KMDPSTCASTGSVQW	ADAM10	601	O14672
SRSQPWDLTPMLSSS	EPN3	356	Q9H201
PISKSLWTCSVESSM	INTS13	46	Q9NVM9
MSRSTKGVSWQSPPS	MUC16	5906	Q8WXI7
SLTMENPWANCSSPL	NOTCH2	1456	Q04721
KVTTPCMSSGSLWDP	IL17RA	191	Q96F46
GMPECNSPVWSRKSS	MYF5	166	P13349
DTSWSPPAMASTSLS	IMPG1	431	Q17R60
LWKPPSRSSSMSSLV	FYCO1	191	Q9BQS8
VSPCSASQEWSSPKK	KIAA1614	101	Q5VZ46
TNSSPMGWSSAAPCT	MICALL2	341	Q8IY33
VSTPSWCQSTEASPK	ERAP1	26	Q9NZ08
CTPQQSRTEKTMATW	PCM1	876	Q15154
MPTLSFWVCSATPVS	OR2T7	1	P0C7T2
STSLPCQCSSTLMWS	PTGER3	371	P43115
SWPKSPESCSSVAES	KDM4C	506	Q9H3R0
MVSSVLPNPTSAECW	OTUD7A	1	Q8TE49
TLTTMVQAWPFTCLP	PRAMEF12	51	O95522
MFSLTPENSWTPKAC	CD109	516	Q6YHK3
WLLSCNTPSSATMSL	EYA4	81	O95677
PMTQTTPLKTSWVNC	IL3	21	P08700
RKWQPVAPMTTTRSC	KLHL28	411	Q9NXS3
KPTCSVCKTTSSSMW	GATAD1	6	Q8WUU5
DMSWSSSLATPPTLS	BRCA2	191	P51587
TKCPNQTTAIDMWSA	CDC7	386	O00311
PSTWCLKEDPATMSL	GARRE1	451	O15063
TPKSWTPSMQSEQNT	CAPRIN2	511	Q6IMN6
SEQNTTKSWTTPMCE	CAPRIN2	521	Q6IMN6
PWQGTMTLSKSTCQD	CST3	131	P01034
SSWKASCSGPLVMAS	FAM181A	51	Q8N9Y4
TCSSNLKSVWPMNTS	MEIOC	156	A2RUB1
ISCNTWPSMPSYSSC	TBX5	396	Q99593
WPSMPSYSSCTVTTV	TBX5	401	Q99593
SKENAWPTKPSSMLS	SLITRK3	301	O94933
TNSPSCTRELSWTPM	SECISBP2	286	Q96T21
DCSLPMIWAQKTNTP	RO60	446	P10155
SKCWSPMGSSDLLAP	STARD8	41	Q92502
TAETALPLTMPCWTC	STON2	121	Q8WXE9
TANTPTPVCKRSMRW	AGAP5	236	A6NIR3
LWKNTSSSMEPTAPL	TDRKH	236	Q9Y2W6
MPASWTSPQKSSALA	ZNF585B	1	Q52M93
GPNPWMLRSCTSDTK	UTP14A	371	Q9BVJ6
TFPIKEPSCSSLWTS	WDR25	106	Q64LD2
CPSPMESSKWLTSQT	WDCP	91	Q9H6R7
TIQNWPSSSCKMTAL	ZYG11A	651	Q6WRX3
VSMWKTSDSVSSPQP	TIMD4	266	Q96H15
PTPMTSKSASVWSKS	TNRC6B	926	Q9UPQ9
SKPSPTICSMNSNIW	TTI1	611	O43156
LPMDSPSSLWTTISN	UNC79	2161	Q9P2D8
SSSWMCPSDPSSQMV	LRRC73	286	Q5JTD7
SAPSSLFECKEWTMP	MYOM3	786	Q5VTT5
SWKSVKTEGMSCPTP	MYT1L	996	Q9UL68