Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentcytosolic [4Fe-4S] assembly targeting complex

CIAO3 MMS19

1.44e-045802GO:0097361
MousePhenoabnormal circulating phosphate level

NCAPD3 TRMT10B AFTPH LRRK1 TRPV5 DNAJB14 SVEP1 SLC39A8

2.91e-05260668MP:0001565
MousePhenoabnormal phosphate level

NCAPD3 TRMT10B AFTPH LRRK1 TRPV5 DNAJB14 SVEP1 SLC39A8

3.07e-05262668MP:0020885
DomainHEAT

PIK3R4 NCAPD3 UTP20 MMS19 SPAG6

1.77e-0648795PF02985
DomainHEAT

PIK3R4 NCAPD3 UTP20 MMS19 SPAG6

4.58e-0658795IPR000357
DomainAAA

ORC4 ATAD5 ATAD2B PEX6

6.88e-0552794PF00004
DomainATPase_AAA_core

ORC4 ATAD5 ATAD2B PEX6

7.98e-0554794IPR003959
DomainHEAT_REPEAT

PIK3R4 NCAPD3 UTP20 MMS19

2.20e-0470794PS50077
DomainE2F_CC-MB

E2F1 E2F4

2.62e-046792IPR032198
DomainE2F_CC-MB

E2F1 E2F4

2.62e-046792PF16421
DomainAAA+_ATPase

ORC4 ATAD5 ATAD2B PEX6 AK9

3.62e-04144795IPR003593
DomainAAA

ORC4 ATAD5 ATAD2B PEX6 AK9

3.62e-04144795SM00382
DomainAAA

ATAD5 ATAD2B PEX6

3.97e-0434793PS00674
DomainE2F

E2F1 E2F4

4.87e-048792IPR015633
DomainAdenylat/UMP-CMP_kin

AK9 AK7

7.78e-0410792IPR000850
DomainE2F_TDP

E2F1 E2F4

9.48e-0411792PF02319
DomainE2F_TDP

E2F1 E2F4

9.48e-0411792SM01372
DomainE2F_WHTH_DNA-bd_dom

E2F1 E2F4

9.48e-0411792IPR003316
DomainARM-like

PIK3R4 NCAPD3 DOCK10 UTP20 MMS19 SPAG6

9.93e-04270796IPR011989
DomainMORN

ALS2CL RSPH10B

1.56e-0314792SM00698
DomainMORN

ALS2CL RSPH10B

1.79e-0315792IPR003409
DomainMORN

ALS2CL RSPH10B

1.79e-0315792PF02493
DomainConA-like_dom

MALRD1 BTNL3 ADGRV1 HNRNPUL1 SVEP1

2.36e-03219795IPR013320
Domain-

PIK3R4 NCAPD3 UTP20 MMS19 SPAG6

2.50e-032227951.25.10.10
DomainARM-type_fold

PIK3R4 NCAPD3 PIK3CD UTP20 MMS19 SPAG6

3.13e-03339796IPR016024
Domain-

MAP1S INTS9

3.19e-03207923.60.15.10
DomainMetallo-B-lactamas

MAP1S INTS9

3.19e-0320792IPR001279
DomainC2_dom

SYT15 PIK3CD SYT4 WWC1

5.17e-03164794IPR000008
DomainBromodomain_CS

BRPF1 ATAD2B

5.38e-0326792IPR018359
DomainATPase_AAA_CS

ATAD2B PEX6

6.66e-0329792IPR003960
PathwayBIOCARTA_ETS_PATHWAY

ETS1 E2F1 E2F4

3.29e-0517533M14449
PathwayBIOCARTA_ETS_PATHWAY

ETS1 E2F1 E2F4

3.29e-0517533MM1435
Pubmed

E2Fs regulate adipocyte differentiation.

E2F1 E2F4

5.63e-06283212110166
Pubmed

PI3Kδ activates E2F1 synthesis in response to mRNA translation stress.

PIK3CD E2F1

5.63e-06283229235459
Pubmed

Integrative Genomic Analyses Yield Cell-Cycle Regulatory Programs with Prognostic Value.

E2F1 E2F4

5.63e-06283226856934
Pubmed

Expression of E2F-1 and E2F-4 is reduced in primary and metastatic breast carcinomas.

E2F1 E2F4

5.63e-06283211759817
Pubmed

Opposite functions for E2F1 and E2F4 in human epidermal keratinocyte differentiation.

E2F1 E2F4

5.63e-06283211005809
Pubmed

E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo.

E2F1 E2F4

5.63e-06283210779331
Pubmed

The E2F1/DNMT1 axis is associated with the development of AR negative castration resistant prostate cancer.

E2F1 DNMT1

5.63e-06283224038143
Pubmed

E2F transcription factors associated with up-regulated genes in glioblastoma.

E2F1 E2F4

5.63e-06283227983535
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

DIMT1 ACAD11 ATAD5 BRPF1 PEX6 MMS19 CSMD1 PADI2 ZMYM3 WWC1 ARHGAP33 FAM83H

1.34e-051116831231753913
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

PIK3R4 NCAPD3 DIMT1 ACAD11 ATAD5 TAF1B UTP20 HNRNPUL1 DDOST DNMT1

1.34e-05759831035915203
Pubmed

Repression of androgen receptor transcription through the E2F1/DNMT1 axis.

E2F1 DNMT1

1.69e-05383221966451
Pubmed

Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation.

E2F1 DNMT1

1.69e-05383224502362
Pubmed

A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members.

E2F1 E2F4

1.69e-05383217908821
Pubmed

An integrated bioinformatics approach identifies elevated cyclin E2 expression and E2F activity as distinct features of tamoxifen resistant breast tumors.

E2F1 E2F4

1.69e-05383221789246
Pubmed

The pro-death role of Cited2 in stroke is regulated by E2F1/4 transcription factors.

E2F1 E2F4

1.69e-05383230967472
Pubmed

FER1L4/miR-372/E2F1 works as a ceRNA system to regulate the proliferation and cell cycle of glioma cells.

FER1L4 E2F1

1.69e-05383230887657
Pubmed

The relationship between E2F family members and tumor growth in colorectal adenocarcinomas: A comparative immunohistochemical study of 100 cases.

E2F1 E2F4

1.69e-05383222688350
Pubmed

Long non-coding RNA-HAGLR suppressed tumor growth of lung adenocarcinoma through epigenetically silencing E2F1.

E2F1 DNMT1

1.69e-05383231194977
Pubmed

DNMT1-Mediated the Downregulation of FOXF1 Promotes High Glucose-induced Podocyte Damage by Regulating the miR-342-3p/E2F1 Axis.

E2F1 DNMT1

3.37e-05483239014186
Pubmed

E2F transcriptional activation requires TRRAP and GCN5 cofactors.

E2F1 E2F4

3.37e-05483211418595
Pubmed

[Benzo(a)pyrene induced changes of cyclin D1, CDK4 and E2F-1/4 expression in human embryo lung fibroblasts].

E2F1 E2F4

3.37e-05483216758952
Pubmed

Identification of cell cycle-regulated genes periodically expressed in U2OS cells and their regulation by FOXM1 and E2F transcription factors.

E2F1 E2F4

3.37e-05483224109597
Pubmed

Transcription of mouse DNA methyltransferase 1 (Dnmt1) is regulated by both E2F-Rb-HDAC-dependent and -independent pathways.

E2F1 DNMT1

3.37e-05483212799438
Pubmed

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.

E2F1 DNMT1

3.37e-05483210888886
Pubmed

Myc requires distinct E2F activities to induce S phase and apoptosis.

E2F1 E2F4

3.37e-05483211511364
Pubmed

Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.

E2F1 E2F4

3.37e-05483220133863
Pubmed

The TRAF-interacting protein (TRAIP) is a novel E2F target with peak expression in mitosis.

E2F1 E2F4

3.37e-05483226369285
Pubmed

Ectopic expression of necdin induces differentiation of mouse neuroblastoma cells.

E2F1 E2F4

3.37e-05483212198120
Pubmed

Intestinal hyperplasia induced by simian virus 40 large tumor antigen requires E2F2.

E2F1 E2F4

3.37e-05483217855529
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

CITED4 BRPF1 TAF1B ETS1 E2F1 MMS19 E2F4 HNRNPUL1 LDB2 DNMT1

4.56e-05877831020211142
Pubmed

A role for E2F6 in the restriction of male-germ-cell-specific gene expression.

E2F1 E2F4

5.60e-05583215936277
Pubmed

Transcriptional regulation of fibrillin-2 gene by E2F family members in chondrocyte differentiation.

E2F1 E2F4

5.60e-05583219142862
Pubmed

G1 cyclin/cyclin-dependent kinase-coordinated phosphorylation of endogenous pocket proteins differentially regulates their interactions with E2F4 and E2F1 and gene expression.

E2F1 E2F4

5.60e-05583212401786
Pubmed

Transcription of the catalytic 180-kDa subunit gene of mouse DNA polymerase alpha is controlled by E2F, an Ets-related transcription factor, and Sp1.

E2F1 E2F4

5.60e-05583211004506
Pubmed

IKK/NF-kappaB signaling pathway inhibits cell-cycle progression by a novel Rb-independent suppression system for E2F transcription factors.

E2F1 E2F4

5.60e-05583218542057
Pubmed

Dynamic site-specific recruitment of RBP2 by pocket protein p130 modulates H3K4 methylation on E2F-responsive promoters.

E2F1 E2F4

5.60e-05583229059406
Pubmed

NCAPD3 promotes prostate cancer progression by up-regulating EZH2 and MALAT1 through STAT3 and E2F1.

NCAPD3 E2F1

5.60e-05583235085770
Pubmed

Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein.

AK9 AK7

5.60e-05583210215863
Pubmed

A role for E2F activities in determining the fate of Myc-induced lymphomagenesis.

E2F1 E2F4

5.60e-05583219749980
Pubmed

pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.

E2F1 E2F4

5.60e-05583210869426
Pubmed

PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.

NCAPD3 E2F1

8.39e-05683220622854
Pubmed

MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E.

E2F1 E2F4

8.39e-05683221454377
Pubmed

E2F: a nodal point in cell cycle regulation.

E2F1 E2F4

8.39e-0568329426200
Pubmed

The regulation of E2F by pRB-family proteins.

E2F1 E2F4

8.39e-0568329694791
Pubmed

Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions.

E2F1 E2F4

8.39e-0568328816797
Pubmed

Regulation of a novel androgen receptor target gene, the cyclin B1 gene, through androgen-dependent E2F family member switching.

E2F1 E2F4

8.39e-05683222508987
Pubmed

Expression of the E2F family of transcription factors during murine development.

E2F1 E2F4

8.39e-05683210853823
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

PIK3R4 DIMT1 MYH14 TAF1B DOCK10 UTP20 MMS19 HNRNPUL1 DDOST ZMYM3 FAM83H DNMT1

8.64e-051353831229467282
Pubmed

Stage-Specific Demethylation in Primordial Germ Cells Safeguards against Precocious Differentiation.

STRA8 DNMT1

1.17e-04783227618282
Pubmed

Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members.

E2F1 E2F4

1.17e-0478328832394
Pubmed

Patterns of cell signaling pathway activation that characterize mammary development.

E2F1 E2F4

1.17e-04783218550711
Pubmed

Identification of a viral kinase that phosphorylates specific E2Fs and pocket proteins.

E2F1 E2F4

1.17e-0478329343408
Pubmed

Aberrant regulation of survivin by the RB/E2F family of proteins.

E2F1 E2F4

1.17e-04783215271987
Pubmed

E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry.

E2F1 E2F4

1.17e-0478328657117
Pubmed

pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer.

E2F4 DNMT1

1.17e-04783212789259
Pubmed

Ectopic expression of cyclin E in estrogen responsive cells abrogates antiestrogen mediated growth arrest.

E2F1 E2F4

1.17e-04783212096339
Pubmed

E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.

E2F1 E2F4

1.17e-04783217612494
Pubmed

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.

E2F1 E2F4

1.17e-0478327892279
Pubmed

Expression patterns of the E2F family of transcription factors during mouse nervous system development.

E2F1 E2F4

1.17e-0478329376316
Pubmed

E2F-6, a member of the E2F family that can behave as a transcriptional repressor.

E2F1 E2F4

1.17e-0478329501179
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

NCAPD3 MYH14 UTP20 MMS19 DNMT1

1.26e-0420283533005030
Pubmed

Expression patterns of the E2F family of transcription factors during murine epithelial development.

E2F1 E2F4

1.56e-0488329149906
Pubmed

Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F.

E2F1 E2F4

1.56e-04883215706352
Pubmed

E2F-4, a new member of the E2F transcription factor family, interacts with p107.

E2F1 E2F4

1.56e-0488327958924
Pubmed

The DP-1 transcription factor is required for keratinocyte growth and epidermal stratification.

E2F1 E2F4

1.56e-04883215448153
Pubmed

Canonical and atypical E2Fs regulate the mammalian endocycle.

E2F1 E2F4

1.56e-04883223064266
Pubmed

EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2.

E2F1 E2F4

1.56e-04883219457859
Pubmed

Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F.

E2F1 E2F4

1.56e-04883217062573
Pubmed

The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase.

AK9 AK7

1.56e-04883223416111
Pubmed

Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600.

E2F1 E2F4

1.56e-04883216061792
Pubmed

Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.

E2F1 E2F4

1.56e-04883216360038
Pubmed

Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark.

E2F1 E2F4

1.56e-04883220855524
Pubmed

An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation.

E2F1 E2F4

2.00e-04983212007404
Pubmed

Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts.

E2F1 E2F4

2.00e-04983217923680
Pubmed

BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases.

E2F1 E2F4

2.50e-04108329244350
Pubmed

Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function.

E2F1 E2F4

2.50e-041083212411495
Pubmed

E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints.

E2F1 E2F4

2.50e-041083211799067
Pubmed

MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells.

STRA8 MEIOSIN

2.50e-041083232032549
Pubmed

IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway.

CIAO3 MMS19

2.50e-041083223585563
Pubmed

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.

E2F1 E2F4

2.50e-04108327797074
Pubmed

Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex.

E2F1 E2F4

2.50e-041083220392944
Pubmed

Macrophage migration inhibitory factor MIF interferes with the Rb-E2F pathway.

E2F1 E2F4

2.50e-041083215664192
Pubmed

Rb is critical in a mammalian tissue stem cell population.

E2F1 E2F4

2.50e-041083217210791
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PITPNM2 MAP1S PIK3CD MYOM3 TIGD3 PEX6 LRRK1 ATG2A ARHGAP33 FAM83H

3.00e-041105831035748872
Pubmed

Strain background effects and genetic modifiers of hearing in mice.

ADGRV1 GIPC3

3.05e-041183216579977
Pubmed

Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression.

E2F1 E2F4

3.05e-041183210766737
Pubmed

Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors.

E2F1 E2F4

3.05e-041183215735762
Pubmed

Specific regulation of E2F family members by cyclin-dependent kinases.

E2F1 E2F4

3.05e-04118329199321
Pubmed

Target gene specificity of E2F and pocket protein family members in living cells.

E2F1 E2F4

3.66e-041283210913163
Pubmed

Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor.

E2F1 E2F4

3.66e-041283212748276
Pubmed

Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.

ATAD5 E2F1 MMS19 ATG2A DDOST

3.85e-0425783530945288
Pubmed

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.

MAP1S EXD2 UTP20 MMS19 ZMYM3

4.20e-0426283536880596
Pubmed

Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.

MYH14 CSMD1

4.31e-041383222993228
Pubmed

Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.

E2F1 E2F4

5.03e-04148329190208
Pubmed

Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation.

E2F1 E2F4

5.03e-041483225150253
Pubmed

STRA8-RB interaction is required for timely entry of meiosis in mouse female germ cells.

STRA8 MEIOSIN

5.03e-041483237880249
Pubmed

A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus.

TIGD3 ATG2A

5.03e-04148329253601
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

NCAPD3 AFTPH MAP1S BRPF1 UTP20 HNRNPUL1 ZMYM3 DNMT1

5.27e-0477483815302935
Pubmed

Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control.

E2F1 E2F4

5.79e-041583217255939
Pubmed

MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.

CIAO3 MMS19

5.79e-041583222678361
GeneFamilyAAA ATPases

ORC4 ATAD5 ATAD2B PEX6

1.87e-0553544413
GeneFamilyE2F transcription factors

E2F1 E2F4

2.42e-048542982
GeneFamilyAdenylate kinases

AK9 AK7

3.11e-049542356
GeneFamilySynaptotagmins

SYT15 SYT4

1.16e-0317542765
ToppCellCOVID-19-Epithelial_cells-ECM-high_epithelial|COVID-19 / group, cell type (main and fine annotations)

THSD4 KCNC2 MYH14 ADGRV1 TM4SF1 SLC39A8 WWC1

5.25e-08183837dc1d380bf7564f290256cb7108063d1bd2da732b
ToppCellCOVID-19-Epithelial_cells-AT1|COVID-19 / group, cell type (main and fine annotations)

THSD4 MYH14 ADGRV1 ALS2CL SLC39A8 WWC1

1.07e-06179836a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

THSD4 MALRD1 ADGRV1 SLC39A8 WWC1 AKAP7

1.07e-06179836cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCellCOVID-19-lung-AT1|COVID-19 / Disease (COVID-19 only), tissue and cell type

MYH14 ADGRV1 ALS2CL SLC39A8 WWC1 TTLL7

1.21e-061838367b1a385ed54f93bfe85bf0c162e42d05d516b45c
ToppCellCOVID-19-lung-AT1|lung / Disease (COVID-19 only), tissue and cell type

MYH14 ADGRV1 ALS2CL SLC39A8 WWC1 TTLL7

1.21e-06183836942530449e9c6583705eeb8f6f12621daea57252
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D175|Adult / Lineage, Cell type, age group and donor

THSD4 MYH14 ALS2CL SLC39A8 WWC1 TTLL7

1.29e-0618583632b4e68e551d435a732f253f6ad83408c759a642
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NCAPD3 HROB ATAD5 ETS1 E2F1 LDB2

1.51e-0619083631de1727822e9818652946dfb962daee77ffad68
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NCAPD3 HROB CENPL ATAD5 E2F1

1.52e-05167835bc132b51dec4e8f1cd2b2cd89f83641976e09292
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

THSD4 MALRD1 SLC39A8 WWC1 AKAP7

1.81e-05173835b799c06a6a5754668e789f70c0c8bc1508568575
ToppCellControl-Epithelial_cells-AT1|Control / group, cell type (main and fine annotations)

MYH14 ALS2CL SLC39A8 AKAP7 TTLL7

1.86e-05174835548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EML6 UGT2B7 SPAG6 SLC39A8 WWC1

1.91e-05175835284fdc7a9d303636a637041846850d19d114861a
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FER1L4 MCHR2 ALS2CL SLC39A8 LDB2

2.07e-05178835674ee5095b98929c29e4f6bd56029a336cc4a38c
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c11-MKI67-FOS|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CENPL ATAD5 UGT2B7 E2F1 ARHGAP33

2.13e-05179835ac987c9425a1b4106d1b8779a2c5461383eae2ae
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NCAPD3 HROB ATAD5 E2F1 TRPV5

2.13e-0517983580112c686a8f85ad5e3cda6e3f3d3d51cf688092
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FER1L4 MCHR2 ALS2CL SLC39A8 LDB2

2.19e-05180835fd8c2059fcb382ffbfe19e598e37a49e1d5637b5
ToppCellFetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PITPNM2 CITED4 STRA8 ETS1 LDB2

2.19e-05180835d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

OR9Q1 MYOM3 GREB1 CSMD1 SLC39A8

2.31e-051828354a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

THSD4 PITPNM2 TM4SF1 GIPC3 LDB2

2.31e-05182835a20017b6a4f9a6a29e090e4dbd7c02ed1495bd50
ToppCellControl-Epithelial_alveolar-AT_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYH14 ADGRV1 PADI2 SLC39A8 WWC1

2.43e-0518483551e129b3fcc2df083eda05a3afe3717218b1e52b
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYH14 ADGRV1 PADI2 SLC39A8 WWC1

2.49e-051858350d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCellEpithelial-alveolar_epithelial_cell_type_1|World / Lineage, Cell type, age group and donor

MYH14 ALS2CL SLC39A8 WWC1 TTLL7

2.56e-0518683509d95daa3387a4814cffaa4b798cc2810c3759d0
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYH14 ALS2CL SLC39A8 WWC1 TTLL7

2.62e-05187835d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NCAPD3 CENPL ATAD5 E2F1 ARHGAP33

2.62e-05187835057569c9437219ecc396aa6e673b1178a2273837
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1|Adult / Lineage, Cell type, age group and donor

THSD4 MYH14 ALS2CL SLC39A8 TTLL7

2.62e-0518783577f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCellEpithelial-Epithelial-D_(Ciliated)|Epithelial / shred on cell class and cell subclass (v4)

AK9 TM4SF1 SPAG6 AK7 RSPH10B

2.69e-051888358f30535a32968a81a304315a49c0d90a77d36948
ToppCellCOVID-19-Epithelial_cells|COVID-19 / group, cell type (main and fine annotations)

THSD4 MYH14 ADGRV1 SLC39A8 WWC1

2.69e-05188835c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCellControl-Epithelial_cells|Control / group, cell type (main and fine annotations)

THSD4 MYH14 ADGRV1 SLC39A8 WWC1

2.69e-05188835707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCell368C-Epithelial_cells-Epithelial-E_(AT2)|368C / Donor, Lineage, Cell class and subclass (all cells)

MYH14 ADGRV1 SLC39A8 WWC1 FAM83H

2.76e-051898356f2322d017b74a1757c81d6e06f50ead8c3dd0cc
ToppCell368C-Epithelial_cells-Epithelial-E_(AT2)-|368C / Donor, Lineage, Cell class and subclass (all cells)

MYH14 ADGRV1 SLC39A8 WWC1 FAM83H

2.76e-05189835926b5fa3064b501a57ba78583e8af33532add455
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D231|Adult / Lineage, Cell type, age group and donor

THSD4 SYT15 MYH14 ALS2CL TTLL7

2.76e-051898355a04cb25f8f0447b2cecdb6c3695029281aca26d
ToppCellEpithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|World / Lineage, Cell type, age group and donor

MALRD1 MYH14 ADGRV1 WWC1 AKAP7

2.90e-05191835d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

THSD4 MYH14 ADGRV1 SLC39A8 WWC1

2.98e-05192835efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellCOVID-19-Endothelial_cells-Inflamed_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

THSD4 PITPNM2 ETS1 TM4SF1 LDB2

3.05e-05193835979ebefa527f86bebeea5d94e626ee6c1cc7d53b
ToppCell3'_v3-blood-Lymphocytic_NK-Cycling_NK|blood / Manually curated celltypes from each tissue

HROB ATAD5 E2F1 TRPV5 DNMT1

3.13e-05194835bf9734abaad603ade2a6a6940918aaf1e1c4e2cd
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYH14 ALS2CL SLC39A8 WWC1 TTLL7

3.21e-05195835a71ba5e4043e2d35a45a2c60a96b087e31832345
ToppCellControl_saline-Epithelial_alveolar-AT_2-Differentiating_AT2|Control_saline / Treatment groups by lineage, cell group, cell type

MYH14 ADGRV1 PADI2 SLC39A8 WWC1

3.37e-0519783544a59dfb889577b3160a5b13ada1276771a00241
ToppCellBronchial-10x5prime-Epithelial-Epi_alveolar-AT1|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MYH14 ALS2CL SLC39A8 WWC1 TTLL7

3.45e-0519883554228dd9a50616d2022712d162a419ed0327cabd
ToppCellsevere-Myeloid-Immature_Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

CITED4 ATAD5 E2F1 ARHGAP33 DNMT1

3.45e-05198835e36303628af3139310c1d7a84d2919b7319bbda4
ToppCellBronchial-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

THSD4 MYH14 ADGRV1 SLC39A8 WWC1

3.53e-051998355f7da3eab58ace6cddb3179a415cd839d5767958
ToppCellCOVID-19-lung-Capillary_2|lung / Disease (COVID-19 only), tissue and cell type

PITPNM2 ETS1 CSMD1 TM4SF1 LDB2

3.53e-05199835793ce71b78a68033ef4419ed571e1dd86b40124f
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

THSD4 MYH14 ADGRV1 SLC39A8 WWC1

3.53e-05199835725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

THSD4 MYH14 ADGRV1 SLC39A8 WWC1

3.53e-051998358587bd98de7767a575088afbea07a1feb4516b9b
ToppCellParenchymal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

THSD4 MYH14 ADGRV1 SLC39A8 WWC1

3.53e-051998355cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

EML6 AK9 SPAG6 AK7 RSPH10B

3.62e-0520083596701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCell(09)_Interm._secr.>cil.|World / shred by cell type by condition

RSPH10B2 AK9 SPAG6 AK7 RSPH10B

3.62e-052008353305e14dba12e94da42f0414fdc7a2c8caf0a183
ToppCellSepsis-URO-Lymphocyte-T/NK-T/NK_proliferative|URO / Disease, condition lineage and cell class

NCAPD3 HROB E2F1 SPAG6 ARHGAP33

3.62e-05200835f277db6cc288a52a5426120c1067608700ee8ccc
ToppCellBiopsy_Other_PF-Immune-Proliferating_Macrophages|Biopsy_Other_PF / Sample group, Lineage and Cell type

NCAPD3 HROB CENPL ATAD5 E2F1

3.62e-0520083561473e8613f39a92002d5b631e6bd563735566e4
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NCAPD3 HROB ATAD5 E2F1 ARHGAP33

3.62e-05200835af3dc76b4507bf4edd265169f5dfbbb8a19eb394
ToppCellmild-T/NK_proliferative|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

NCAPD3 ATAD5 E2F1 ARHGAP33 DNMT1

3.62e-0520083563cc57b9331459efbb73051d174d198a3568b938
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c10-IFNG|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

KCNC2 TM4SF1 SVEP1 RSPH10B

9.08e-05126834d19382597ce5c6546731ac1fd33c7dcb7916b2ea
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MALRD1 AK7 SVEP1 ARHGAP33

1.15e-0413483464979e1a056b7406e1be39c5ebe2f8d731ac3c17
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

HROB ETS1 SPAG6 LDB2

1.52e-04144834f501e11b1d051ca67124137017a79a2d5bb6ae87
ToppCellDividing_Macrophages-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

HROB ACAD11 CENPL ATAD5

1.87e-04152834e39cfc346b35235546b303e7d73e4d9d7120a5fb
ToppCellE16.5-samps-Endothelial-Immature_fetal_endothelial-Matrix_Endothelial|E16.5-samps / Age Group, Lineage, Cell class and subclass

CIAO3 TM4SF1 AK7 LDB2

1.97e-04154834928f49839b046b90c2f942458f3e365ddc4e0bc9
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ETS1 TM4SF1 LDB2 DNMT1

2.12e-041578342c946c6ab284fac3c25db688ed0aabe5a3f9ffa5
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D122|Adult / Lineage, Cell type, age group and donor

PITPNM2 ADGRV1 SLC39A8 WWC1

2.12e-0415783431d1bd9138c60e8485664ec4144f987226e3eef9
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYT15 TIGD3 E2F1 SNX19

2.22e-041598344000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ETS1 E2F1 ARHGAP33 LDB2

2.22e-04159834c960df9e4fa980401941866b5081facac4590b4d
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYT15 TIGD3 E2F1 SNX19

2.22e-041598347619d0d49738dd08daf01b42664691a5323aa793
ToppCell10x5'-Lung-Lymphocytic_NK-NK_CD56bright_CD16-|Lung / Manually curated celltypes from each tissue

PITPNM2 ETS1 TIGD3 LDB2

2.22e-04159834595643e9433265308e5aab7f906229025701cf6a
ToppCelldroplet-Kidney-nan-18m-Lymphocytic-NK_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CITED4 ETS1 DOCK10 PADI2

2.27e-04160834398f162e8a75c6cb5c3e4d1832e98d386e1f222b
ToppCellPND07-Epithelial-Epithelial_Airway-Neurosecretory-Secretory|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYH14 AK9 AK7 WWC1

2.27e-04160834028b5261a1da832d52f66fb620db83e5fbbd874a
ToppCellPND07-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYH14 AK9 AK7 WWC1

2.27e-041608341f4ee446436726c3d373f56d87dd80b6a12e8b9e
ToppCelldroplet-Kidney-nan-18m-Lymphocytic-CD45____NK_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CITED4 ETS1 DOCK10 PADI2

2.27e-0416083412aaab0291035f578e2433efd169ae72f393a5a5
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KCNC2 ETS1 MMS19 FBXO21

2.33e-041618342849fbc9611af208241b33da3cd18290aafe426b
ToppCellkidney_cells-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FER1L4 EML6 LRRK1 DDOST

2.39e-04162834ee6f05620f4f4ebbebd5b098afc7c20876e3d21f
ToppCellkidney_cells-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FER1L4 EML6 LRRK1 DDOST

2.39e-041628349e72d468fcdd0d27b517a9e36efb35d4617a88f9
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Adult / Lineage, Cell type, age group and donor

PITPNM2 ADGRV1 SLC39A8 WWC1

2.44e-04163834e819a1d6d28290854aa0672b3a18fa9e293d8f23
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SYT15 ACAD11 TM4SF1 LDB2

2.56e-0416583462457b7b74c6eae42d91d65e7dc6df6bf8e061f7
ToppCell368C-Myeloid-Macrophage-FABP4+_Macrophage_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

PITPNM2 TIGD3 ADGRV1 TTLL7

2.56e-041658343d2acdae0dd2b79a15f74158e8e566ce22b4218e
ToppCelldroplet-Heart-nan-18m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA3D ADGRV1 ARHGAP33 FAM83H

2.62e-041668349adceb746e67e955fd8b3e0984f4eed44b64a270
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ATAD5 EML6 E2F1 DNMT1

2.68e-04167834108ae6221c6edc63c0ec42c42471b3a15a594043
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D231|Adult / Lineage, Cell type, age group and donor

THSD4 ETS1 GIPC3 LDB2

2.68e-041678345af9127bae05768a5164d5708a4ad37edca99324
ToppCellnormal_Lung-Fibroblasts-Mesothelial_cells|Fibroblasts / Location, Cell class and cell subclass

SYT4 TM4SF1 SLC39A8 WWC1

2.68e-04167834892a2dc83ab5de5a1016402f8e95d2aabf651326
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CENPL ATAD5 E2F1 DNMT1

2.80e-04169834b253a4a50c06d36228fcd5d856c57202cbac158f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 KCNC2 SVEP1 LDB2

2.80e-04169834a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CITED4 PEX6 ADGRV1 SVEP1

2.87e-04170834ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

PITPNM2 MYH14 ADGRV1 WWC1

2.87e-04170834a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCellControl-Epithelial_cells-ECM-high_epithelial|Control / group, cell type (main and fine annotations)

ADGRV1 SLC39A8 LDB2 AKAP7

2.87e-04170834e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCellPND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATAD5 MEIOSIN SLC39A8 GIPC3

2.87e-041708344ce81608111b9ee7cb974dad2c182f38db3dcd79
ToppCellwk_08-11-Epithelial-Proximal_epithelial-Deuterosomal|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

DNAH17 SPAG6 AK7 RSPH10B

3.00e-0417283408ad76412c9cc3504141797b44b88478ced87476
ToppCell367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|367C / Donor, Lineage, Cell class and subclass (all cells)

SYT15 E2F1 ADGRV1 WWC1

3.00e-04172834a9e65201ad9ab4f64251aba2c0bb3d8f9e0193b6
ToppCell367C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|367C / Donor, Lineage, Cell class and subclass (all cells)

SYT15 E2F1 ADGRV1 WWC1

3.00e-0417283426006967d0c82f7bd9b36a18e97a1b93e856aa67
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NCAPD3 ATAD5 ARHGAP33 DNMT1

3.00e-041728342b6cd84c946b1e800caba452ae70145ea285fec1
ToppCelldroplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TIGD3 FBXO21 SLC39A8 GIPC3

3.00e-04172834b043d4f81dced7fb3326043f68474123be47cc5d
ToppCelldroplet-Fat-Scat-21m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PITPNM2 TM4SF1 SLC39A8 TTLL7

3.06e-04173834f13124b4cf2ac1dc2895f90f5487d6ac681b0ba4
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NCAPD3 ATAD5 LRRK1 ARHGAP33

3.06e-0417383420889aa85e36ad3bafdb91b91e43964493c949f9
ToppCell368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NCAPD3 ATAD5 LRRK1 ARHGAP33

3.06e-0417383446e601b7938b1dd0aa3df7aa056c4bd07b1620c1
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NCAPD3 HROB ATAD5 E2F1

3.13e-0417483484da9faff088d05233183b425385beb054c92d1b
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NCAPD3 MEIOSIN LDB2 DNMT1

3.13e-0417483466555c610251ea04f968c258e312d720c18e7cde
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYH14 EML6 WWC1 ARHGAP33

3.20e-0417583496219e58dcb327fd27190be78193e7a0d611e62b
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYH14 EML6 WWC1 ARHGAP33

3.20e-04175834cb974fbebe8cb58c7d3f7defabb4e056f2fee5fa
ToppCellPND07-28-samps-Epithelial-Epithelial-non_alveolar|PND07-28-samps / Age Group, Lineage, Cell class and subclass

MYH14 SPAG6 AK7 RSPH10B

3.20e-04175834c01a15b2084da4a18f8ff3623f44eb9dfe499f10
ToppCellASK452-Endothelial-Lymphatic|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

SEMA3D MMS19 TM4SF1 LDB2

3.27e-04176834b4d280ecc07701d526f50d44c45ea91b3eeb00b1
ToppCellfacs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

THSD4 SEMA3D GIPC3 LDB2

3.27e-04176834460cb302c5b3d609c65b924e1d4e8ea057a68485
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_LINC00507_CTXN3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FER1L4 MCHR2 ALS2CL LDB2

3.34e-0417783496d639407f79669f3990138793d157b94273581c
ToppCellmetastatic_Lymph_Node-Endothelial_cells|metastatic_Lymph_Node / Location, Cell class and cell subclass

THSD4 SYT15 SEMA3D LDB2

3.34e-0417783471bf5d4bc67bda37a0499e5ec01af7dd5254041d
ToppCellfacs-Lung-EPCAM-18m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNC2 ALS2CL TM4SF1 LDB2

3.34e-041778342433924dcb085ebbe2545d476ebd7ee68e6092fb
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3-4_RORB_FOLH1B|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FER1L4 MCHR2 ALS2CL SLC39A8

3.41e-0417883422955b82917206aeed49dc0ac4630ccd9e51c4a5
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EML6 UGT2B7 SLC39A8 WWC1

3.41e-04178834c20f050344a2e120e685e2a7fe36c6dfc1dc37b6
DrugMuramic acid, N-acetyl [10597-89-4]; Up 200; 13.6uM; PC3; HT_HG-U133A

HROB DIMT1 ATAD5 LRRK1 SVEP1 WWC1 LDB2

6.39e-061968174582_UP
DrugAcyclovir [59277-89-3]; Up 200; 17.8uM; MCF7; HT_HG-U133A

HROB MAP1S MYH14 ATAD5 DOCK10 TM4SF1 AKAP7

6.61e-061978171543_UP
DrugGalanthamine hydrobromide [1953-04-4]; Up 200; 10.8uM; MCF7; HT_HG-U133A

THSD4 DIMT1 MYH14 FBXO21 ALS2CL TM4SF1 SVEP1

7.06e-061998172787_UP
DrugLY294002; Up 200; 10uM; PC3; HT_HG-U133A

SEMA3D HROB MYH14 MRNIP FBXO21 TM4SF1

6.20e-051918165970_UP
DrugSparteine (-) [90-39-1]; Up 200; 17uM; MCF7; HT_HG-U133A

THSD4 HROB PIK3CD DOCK10 FBXO21 AKAP7

6.96e-051958162790_UP
DrugHippeastrine hydrobromide [22352-41-6]; Up 200; 10uM; PC3; HT_HG-U133A

ETS1 DOCK10 LRRK1 TM4SF1 PADI2 LDB2

7.16e-051968163682_UP
DrugEtilefrine hydrochloride [534-87-2]; Down 200; 18.4uM; PC3; HT_HG-U133A

DIMT1 MYH14 MRNIP E2F4 TM4SF1 ARHGAP33

7.16e-051968164590_DN
DrugEthaverine hydrochloride [985-13-7]; Down 200; 9.2uM; PC3; HT_HG-U133A

MAP1S CIAO3 MRNIP LRRK1 WWC1 AKAP7

7.36e-051978166737_DN
Drugaspirin, USP; Up 200; 100uM; PC3; HT_HG-U133A

ATAD5 PIK3CD PEX6 MRNIP LRRK1 AKAP7

7.36e-051978161204_UP
DrugGelsemine [509-15-9]; Down 200; 12.4uM; PC3; HT_HG-U133A

MYH14 ETS1 E2F4 FBXO21 SVEP1 AKAP7

7.36e-051978164097_DN
DrugTriflupromazine hydrochloride [1098-60-8]; Down 200; 10.2uM; HL60; HT_HG-U133A

ORC4 DIMT1 ATAD5 PEX6 E2F1 FBXO21

7.36e-051978161855_DN
DrugPanthenol (D) [81-13-0]; Down 200; 19.4uM; MCF7; HT_HG-U133A

CIAO3 TAF1B ALS2CL PADI2 ZMYM3 AKAP7

7.36e-051978161680_DN
DrugCiprofloxacin hydrochloride [93107-08-5]; Up 200; 10.8uM; MCF7; HT_HG-U133A

THSD4 MAP1S PIK3CD DOCK10 GREB1 ARHGAP33

7.57e-051988161522_UP
DrugAlverine citrate salt [5560-59-8]; Up 200; 8.4uM; HL60; HG-U133A

MYH14 ATAD2B E2F1 MRNIP E2F4 WWC1

7.57e-051988161426_UP
DrugQuinic acid [86-68-0]; Down 200; 19.6uM; MCF7; HT_HG-U133A

ATAD5 BRPF1 TAF1B E2F4 ARHGAP33 AKAP7

7.57e-051988166019_DN
Drug(-)-MK 801 hydrogen maleate [77086-19-2]; Down 200; 11.8uM; MCF7; HT_HG-U133A

DIMT1 MYH14 PIK3CD E2F1 GREB1 ALS2CL

7.78e-051998166458_DN
DrugOxalamine citrate salt [1949-20-8]; Down 200; 9.2uM; PC3; HT_HG-U133A

DIMT1 MYH14 CIAO3 BRPF1 DNAH17 LRRK1

7.78e-051998166624_DN
Diseasecortical surface area measurement

THSD4 PITPNM2 NCAPD3 SEMA3D ACAD11 PMPCA PIK3CD ATAD2B ETS1 DOCK10 SYT4 ADGRV1 SVEP1 SLC39A8 WWC1

3.38e-0613458115EFO_0010736
Disease2-stearoylglycerophosphocholine measurement

MALRD1 EML6

7.44e-062812EFO_0021098
Diseasesexual dimorphism measurement

PITPNM2 HROB CITED4 PMPCA ATAD5 CIAO3 FER1L4 WBP1L ATAD2B E2F1 SLC39A8 AKAP7

4.72e-0511068112EFO_0021796
Diseasebrain measurement, hippocampal volume

MALRD1 UTP20

1.11e-046812EFO_0004464, EFO_0005035
Diseaseglioblastoma (is_marker_for)

KCNC2 PIK3CD E2F1

2.43e-0444813DOID:3068 (is_marker_for)
Diseasepulse pressure measurement

PIK3R4 THSD4 MALRD1 WBP1L ATAD2B UGT2B7 DDI2 SYT4 SNX19 SVEP1 LDB2 DNMT1

4.02e-0413928112EFO_0005763
DiseaseCCL2 measurement

CITED4 ETS1 GREB1 ALS2CL

4.09e-04126814EFO_0004749
Diseasemonocyte percentage of leukocytes

CITED4 MAP1S EBLN1 PMPCA WBP1L ETS1 DOCK10 SLC39A8

8.95e-04731818EFO_0007989
DiseaseNonsyndromic Deafness

MYH14 ADGRV1 GIPC3

1.46e-0381813C3711374
DiseaseICAM-1 measurement

SYT4 DNMT1

1.98e-0324812EFO_0004520
DiseaseLynch syndrome (is_implicated_in)

TAF1B E2F4

1.98e-0324812DOID:3883 (is_implicated_in)
Diseasecolorectal health

KCNC2 ADGRV1 CSMD1 LDB2

2.31e-03201814EFO_0008460
Diseasecerebellum cortex volume change measurement, age at assessment

CSMD1 WWC1

2.32e-0326812EFO_0008007, EFO_0021497
Diseaseresponse to norepinephrine-dopamine reuptake inhibitor

ADGRV1 AK7

2.32e-0326812EFO_0007870
Diseasechronic myeloid leukemia (is_marker_for)

E2F1 DNMT1

2.50e-0327812DOID:8552 (is_marker_for)
Diseasehearing impairment

ADGRV1 GIPC3 DNMT1

2.51e-0398813C1384666
Diseasemean arterial pressure

WBP1L EML6 DOCK10 SVEP1 SLC39A8 DNMT1

2.53e-03499816EFO_0006340
Diseaselumbar disc degeneration

MYH14 CSMD1

2.69e-0328812EFO_0004994

Protein segments in the cluster

PeptideGeneStartEntry
DGCTFHLLTPEEEFS

ALS2CL

281

Q60I27
DGCFEEIKFSTPSLL

ATAD5

1346

Q96QE3
LVGEDAVFSCSLFPE

BTNL3

31

Q6UXE8
GDTLTFECPAAFELV

CSMD1

546

Q96PZ7
GATSDPLELFLVDEC

DNMT1

806

P26358
FEACFPSILVPDAEE

AFTPH

656

Q6ULP2
CFPFSRDEGKISELE

AKAP7

6

O43687
DDPFGVFILDPECLE

ADGRV1

1236

Q8WXG9
RCLDSVLGEFAFPDE

GIPC3

281

Q8TF64
TLDSDEFCILDAPGL

ATG2A

1356

Q2TAZ0
LIAEETGKCFFAPDV

ACAD11

451

Q709F0
FVDSVPEFCLPETEL

INTS9

76

Q9NV88
PTRLCDLFITGEDFD

MRNIP

326

Q6NTE8
SCPVIFILDEFDLFA

ORC4

151

O43929
GFPDLEVEFISCLDL

RSPH10B

341

P0C881
GFPDLEVEFISCLDL

RSPH10B2

341

B2RC85
NLEGPEIFFEDELVC

FBXO21

136

O94952
TSEIDFIFCDLPPLL

OR9Q1

171

Q8NGQ5
PADVCGPLFEEELAF

KCNC2

126

Q96PR1
GLCEFLEYVAESLEP

MAP1S

206

Q66K74
AFFSTLCPEGDIDIL

GREB1

601

Q4ZG55
EFEDPELSATLCELS

WWC1

566

Q8IX03
EFPAFLSESLEVLCL

LRRK1

541

Q38SD2
SLGPFVEELFEVTSC

MMS19

206

Q96T76
EASTDSFEGIPVLEC

ATAD2B

1271

Q9ULI0
LAPCEDFLLFGVLFE

FER1L4

421

A9Z1Z3
DDATLTLSFCLEDGP

LDB2

61

O43679
RSELEDFPVLGIDCE

EXD2

96

Q9NVH0
DCFLELAPDFVGDIL

ETS1

111

P14921
TFLDFGLDLQPCIDL

MYH14

526

Q7Z406
APCIIFFDELDSLAP

PEX6

796

Q13608
DGLLSELPEDFFCGT

HROB

631

Q8N3J3
AELLFFVEGLCFPDE

PADI2

246

Q9Y2J8
DFEITDLFLFGCPLG

PITPNM2

716

Q9BZ72
DPLRELGSECGIEFD

DDOST

136

P39656
AFFEEVCLDLESSPS

MEIOSIN

391

C9JSJ3
DIFIALDDISFTPEC

MALRD1

1876

Q5VYJ5
VESCAFDLTSPDDVL

MCHR2

181

Q969V1
CLEGLRGLDFDPLTF

ARHGAP33

731

O14559
FGEFESPACELLDQV

EBLN1

211

P0CF75
IRDLFDCDFGDLTPL

E2F1

421

Q01094
LDESEGVCDLFDVPV

E2F4

396

Q16254
PSPEVSDFFSILDVC

DOCK10

1361

Q96BY6
LETVSEDFTCLPLFL

CENPL

171

Q8N0S6
DLDPKAVTCDELFGI

DNAH17

2156

Q9UFH2
AFLLIEDLTGSCFEP

FITM1

141

A5D6W6
GCEADITPEDLFNIF

DNAJB14

191

Q8TBM8
DDFGLVKLFDFPCTE

EML6

1901

Q6ZMW3
IEGDFLPCSFSILEE

DDI2

301

Q5TDH0
FLATEGAPDFLCPEE

FAM83H

46

Q6ZRV2
TIVEFECRGLEPVDF

CZIB

96

Q9NWV4
VGDVLKTDLPFFDTC

DIMT1

111

Q9UNQ2
TLPDVGDFLDEVLFI

HNRNPUL1

566

Q9BUJ2
PLLDLECTDTYFVGL

OR4A8

181

P0C604
ELFVFDIPCEGLEDI

SYT4

356

Q9H2B2
DIPCEGLEDISVEFL

SYT4

361

Q9H2B2
LGEFEQFCPVSLAES

AK9

1636

Q5TCS8
SCSFLEEDFIPFAVL

PMPCA

326

Q10713
LICGLFVESEGVDFE

UTP20

2386

O75691
ESLEPPSEFGDLQFC

SYT15

271

Q9BQS2
ALDTLVICLEDFDPG

SPAG6

126

O75602
TFLDLPRFPDITEDC

TAF1B

286

Q53T94
AIPENGCIEELAFTF

SVEP1

1851

Q4LDE5
IFGIEFNSTFLECIP

SEMA3D

601

O95025
CSLVSTPEEILFEDA

STRA8

236

Q7Z7C7
CFANTVFLEPIDSIE

BRPF1

361

P55201
LTDLDDFIGPSQECI

CIAO3

11

Q9H6Q4
ELPELFLGQSEFDCF

CITED4

156

Q96RK1
CFADGILPLDLDASE

NCAPD3

1126

P42695
CVIAELFTEGVPLFD

PIK3R4

246

Q99570
DFSPEDVFGCAELPL

TIGD3

166

Q6B0B8
VLSALELLDFSFPDC

PIK3CD

576

O00329
FLCEDSELESPLSEL

SNX19

366

Q92543
LLPAFVFIGLEQDDC

TM4SF1

61

P30408
LCEEFPHELGDFVIL

SLC39A8

341

Q9C0K1
LLDITEEDCFSLFPL

TRMT10B

191

Q6PF06
DVIFADAIFPCSELL

UGT2B7

146

P16662
TFEVLDPSECSFLEK

THSD4

886

Q6ZMP0
TLIDDALDGPLDFCD

WBP1L

271

Q9NX94
DINPSVDFLFDCGLV

ZMYM3

1006

Q14202
VDFLFDCGLVGPEDV

ZMYM3

1011

Q14202
ESVCFEVLGFDILLD

TTLL7

326

Q6ZT98
AAPELVFEPTTCEAF

TRPV5

101

Q9NQA5
IIPEFVCALDASDEF

AK7

516

Q96M32
EPFSLSCLFSEDVLD

MYOM3

286

Q5VTT5