Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	signaling receptor complex adaptor activity	GRIP1 IRS2 SH2B2 SHANK3	1.03e-04	54	90	4	GO:0030159
GeneOntologyMolecularFunction	phosphatidic acid binding	COMMD1 GSDMD JPH2	1.67e-04	24	90	3	GO:0070300
Domain	VASP_tetra	ENAH VASP	6.72e-05	3	89	2	IPR014885
Domain	K_chnl_volt-dep_Kv6	KCNG2 KCNG1	6.72e-05	3	89	2	IPR003969
Domain	VASP_tetra	ENAH VASP	6.72e-05	3	89	2	PF08776
Domain	FERM_f0	TLN1 SHANK3	1.34e-04	4	89	2	IPR032425
Domain	FERM_f0	TLN1 SHANK3	1.34e-04	4	89	2	PF16511
Domain	G_patch	ZGPAT RBM5 GPKOW	1.73e-04	23	89	3	SM00443
Domain	G_patch_dom	ZGPAT RBM5 GPKOW	1.73e-04	23	89	3	IPR000467
Domain	G_PATCH	ZGPAT RBM5 GPKOW	1.73e-04	23	89	3	PS50174
Domain	G-patch	ZGPAT RBM5 GPKOW	1.73e-04	23	89	3	PF01585
Domain	A1pp	PARP14 PARP15	7.91e-04	9	89	2	SM00506
Domain	Macro	PARP14 PARP15	7.91e-04	9	89	2	PF01661
Domain	-	ZGPAT TRMT1 ZC3H3	9.10e-04	40	89	3	4.10.1000.10
Domain	IG_FLMN	FLNC TRIM3	9.86e-04	10	89	2	SM00557
Domain	MACRO	PARP14 PARP15	9.86e-04	10	89	2	PS51154
Domain	Macro_dom	PARP14 PARP15	9.86e-04	10	89	2	IPR002589
Domain	WH1	ENAH VASP	1.20e-03	11	89	2	SM00461
Domain	Filamin	FLNC TRIM3	1.20e-03	11	89	2	PF00630
Domain	WH1/EVH1_dom	ENAH VASP	1.20e-03	11	89	2	IPR000697
Domain	WH1	ENAH VASP	1.20e-03	11	89	2	PF00568
Domain	FILAMIN_REPEAT	FLNC TRIM3	1.20e-03	11	89	2	PS50194
Domain	Filamin/ABP280_rpt	FLNC TRIM3	1.20e-03	11	89	2	IPR001298
Domain	Filamin/ABP280_repeat-like	FLNC TRIM3	1.20e-03	11	89	2	IPR017868
Domain	ZnF_C3H1	ZGPAT TRMT1 ZC3H3	1.55e-03	48	89	3	SM00356
Domain	zf-CCCH	ZGPAT TRMT1 ZC3H3	1.64e-03	49	89	3	PF00642
Domain	WH1	ENAH VASP	1.69e-03	13	89	2	PS50229
Domain	IRS_PTB	TLN1 IRS2	1.97e-03	14	89	2	IPR002404
Domain	IRS	TLN1 IRS2	1.97e-03	14	89	2	PF02174
Domain	Znf_CCCH	ZGPAT TRMT1 ZC3H3	2.67e-03	58	89	3	IPR000571
Domain	ZF_C3H1	ZGPAT TRMT1 ZC3H3	2.67e-03	58	89	3	PS50103
Domain	Poly(ADP-ribose)pol_cat_dom	PARP14 PARP15	2.91e-03	17	89	2	IPR012317
Domain	PARP_CATALYTIC	PARP14 PARP15	2.91e-03	17	89	2	PS51059
Domain	PARP	PARP14 PARP15	2.91e-03	17	89	2	PF00644
Domain	-	PARP14 PARP15	2.91e-03	17	89	2	3.90.228.10
Domain	WGR_domain	PARP14 PARP15	5.79e-03	24	89	2	IPR008893
Pubmed	TES is a novel focal adhesion protein with a role in cell spreading.	GRIP1 TLN1 ENAH VASP	6.85e-10	6	92	4	12571287
Pubmed	Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP.	FLNC ENAH VASP	1.78e-07	5	92	3	16631741
Pubmed	The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions.	TLN1 ENAH VASP	9.94e-07	8	92	3	12695497
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	ANKRD35 FOXD3 BMP6 TFCP2L1 ENAH ID3 TIMM17A NKX2-2 FOXA2	1.94e-06	424	92	9	21731673
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	FLNC RTCB GSDMD SEPTIN9 TLN1 GART CC2D1A GPKOW	5.33e-06	360	92	8	33111431
Pubmed	Cullin 4A/protein arginine methyltransferase 5 (CUL4A/PRMT5) promotes cell malignant phenotypes and tumor growth in nasopharyngeal carcinoma.	CUL4A PRMT5	6.92e-06	2	92	2	35333690
Pubmed	Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci.	EYA4 PDZD2	6.92e-06	2	92	2	21061259
Pubmed	Distribution, cellular localization, and postnatal development of VASP and Mena expression in mouse tissues.	ENAH VASP	6.92e-06	2	92	2	11810195
Pubmed	Ena/VASP proteins contribute to Listeria monocytogenes pathogenesis by controlling temporal and spatial persistence of bacterial actin-based motility.	ENAH VASP	6.92e-06	2	92	2	12940993
Pubmed	Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy.	ENAH VASP	6.92e-06	2	92	2	12933343
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	FLNC FOXD3 EYA4 PHF20L1 RECQL4 ID3 KDM1B ECPAS FOXA2 TRIM3 LACTB	1.67e-05	857	92	11	25609649
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	GRIP1 SEPTIN9 TLN1 PAK4 GART CC2D1A IRS2 ECPAS ARHGEF26 SMCR8	1.84e-05	708	92	10	39231216
Pubmed	Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene.	BMP6 NKX2-2 FOXA2	1.98e-05	20	92	3	11071781
Pubmed	An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis.	ENAH VASP	2.07e-05	3	92	2	21423205
Pubmed	B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity.	PARP14 PARP15	2.07e-05	3	92	2	16061477
Pubmed	A Requirement for Mena, an Actin Regulator, in Local mRNA Translation in Developing Neurons.	ENAH VASP	2.07e-05	3	92	2	28735747
Pubmed	VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis.	ENAH VASP	2.07e-05	3	92	2	19435808
Pubmed	Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.	IRS2 FOXA2	2.07e-05	3	92	2	12869553
Pubmed	Cell autonomous defects in cortical development revealed by two-color chimera analysis.	ENAH VASP	2.07e-05	3	92	2	19386231
Pubmed	Conserved transcriptional regulatory domains of the pdx-1 gene.	NKX2-2 FOXA2	2.07e-05	3	92	2	14701942
Pubmed	Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy.	ENAH VASP	2.07e-05	3	92	2	23937664
Pubmed	Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins.	ENAH VASP	2.07e-05	3	92	2	10801818
Pubmed	Identification of an embryonic differentiation stage marked by Sox1 and FoxA2 co-expression using combined cell tracking and high dimensional protein imaging.	NKX2-2 FOXA2	2.07e-05	3	92	2	39251590
Pubmed	Serum methylation levels of TAC1. SEPT9 and EYA4 as diagnostic markers for early colorectal cancers: a pilot study.	EYA4 SEPTIN9	2.07e-05	3	92	2	23862763
Pubmed	Recurrent Amplification at 13q34 Targets at CUL4A, IRS2, and TFDP1 As an Independent Adverse Prognosticator in Intrahepatic Cholangiocarcinoma.	CUL4A IRS2	2.07e-05	3	92	2	26684807
Pubmed	Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning.	BMP6 NKX2-2 FOXA2	2.66e-05	22	92	3	15789444
Pubmed	A census of human transcription factors: function, expression and evolution.	FOXD3 TFCP2L1 AIRE ID3 SP5 NKX2-2 RUNX1 FOXA2 ZC3H3 TCFL5 IRX4	2.84e-05	908	92	11	19274049
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	RTCB POLDIP3 SEPTIN9 TLN1 PAK4 GART ENAH CC2D1A IRS2 SMCR8 GPKOW	3.66e-05	934	92	11	33916271
Pubmed	Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord.	FOXD3 BMP6 ID3	3.95e-05	25	92	3	15469980
Pubmed	FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site.	NKX2-2 FOXA2	4.14e-05	4	92	2	16847327
Pubmed	Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.	ENAH VASP	4.14e-05	4	92	2	15469845
Pubmed	Ena/VASP is required for endothelial barrier function in vivo.	ENAH VASP	4.14e-05	4	92	2	17998398
Pubmed	Biochemical analysis of the human ENA/VASP-family proteins, MENA, VASP and EVL, in homologous recombination.	ENAH VASP	4.14e-05	4	92	2	21398369
Pubmed	Undulated short-tail deletion mutation in the mouse ablates Pax1 and leads to ectopic activation of neighboring Nkx2-2 in domains that normally express Pax1.	NKX2-2 FOXA2	4.14e-05	4	92	2	14504237
Pubmed	Mena binds α5 integrin directly and modulates α5β1 function.	ENAH VASP	4.14e-05	4	92	2	22908313
Pubmed	The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation.	PRMT5 RUNX1	4.14e-05	4	92	2	22193545
Pubmed	Mena and vasodilator-stimulated phosphoprotein are required for multiple actin-dependent processes that shape the vertebrate nervous system.	ENAH VASP	4.14e-05	4	92	2	15371503
Pubmed	Negative Regulation of mTOR Signaling Restricts Cell Proliferation in the Floor Plate.	NKX2-2 FOXA2	4.14e-05	4	92	2	31607856
Pubmed	The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development.	NKX2-2 FOXA2	4.14e-05	4	92	2	19767740
Pubmed	Mena is required for neurulation and commissure formation.	ENAH VASP	4.14e-05	4	92	2	10069337
Pubmed	Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton.	GDF5 BMP6	6.89e-05	5	92	2	9603738
Pubmed	PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins.	ENAH VASP	6.89e-05	5	92	2	15642358
Pubmed	Dysplastic spondylolysis is caused by mutations in the diastrophic dysplasia sulfate transporter gene.	GDF5 FOXA2	6.89e-05	5	92	2	26077908
Pubmed	A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling.	NKX2-2 FOXA2	6.89e-05	5	92	2	25340710
Pubmed	The state of the actin cytoskeleton determines its association with gephyrin: role of ena/VASP family members.	ENAH VASP	6.89e-05	5	92	2	16376568
Pubmed	A requirement for filopodia extension toward Slit during Robo-mediated axon repulsion.	ENAH VASP	6.89e-05	5	92	2	27091449
Pubmed	Spectrin interacts with EVL (Enabled/vasodilator-stimulated phosphoprotein-like protein), a protein involved in actin polymerization.	ENAH VASP	6.89e-05	5	92	2	16336193
Pubmed	The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.	CUL4A EYA4 RECQL4	7.63e-05	31	92	3	32355176
Pubmed	Nato3 plays an integral role in dorsoventral patterning of the spinal cord by segregating floor plate/p3 fates via Nkx2.2 suppression and Foxa2 maintenance.	NKX2-2 FOXA2	1.03e-04	6	92	2	24401371
Pubmed	Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand.	NKX2-2 FOXA2	1.03e-04	6	92	2	25231763
Pubmed	Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains.	PARP14 PARP15	1.03e-04	6	92	2	23473667
Pubmed	Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis.	ENAH VASP	1.03e-04	6	92	2	24076656
Pubmed	Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells.	BMP6 ID3	1.03e-04	6	92	2	15161906
Pubmed	Mouse profilin 2 regulates endocytosis and competes with SH3 ligand binding to dynamin 1.	ENAH VASP	1.03e-04	6	92	2	16319076
Pubmed	Dopaminergic Neurons and Brain Reward Pathways: From Neurogenesis to Circuit Assembly.	NKX2-2 FOXA2	1.03e-04	6	92	2	26724386
Pubmed	The E3 Ubiquitin Ligase TRIM9 Is a Filopodia Off Switch Required for Netrin-Dependent Axon Guidance.	ENAH VASP	1.03e-04	6	92	2	26702829
Pubmed	Lineage specificity of primary cilia in the mouse embryo.	NKX2-2 FOXA2	1.03e-04	6	92	2	25599390
Pubmed	DEPDC1B coordinates de-adhesion events and cell-cycle progression at mitosis.	GRIP1 SEPTIN9 LACTB	1.10e-04	35	92	3	25458010
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	CUL4A SEPTIN9 TLN1 KDM1B ECPAS	1.26e-04	182	92	5	31067453
Pubmed	RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion.	ENAH VASP	1.44e-04	7	92	2	15469846
Pubmed	Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells.	GRIP1 SHANK3	1.44e-04	7	92	2	15207857
Pubmed	Restriction of BMP4 activity domains in the developing neural tube of the mouse embryo.	NKX2-2 FOXA2	1.44e-04	7	92	2	15218525
Pubmed	Survival of Hoxa13 homozygous mutants reveals a novel role in digit patterning and appendicular skeletal development.	GDF5 BMP6	1.44e-04	7	92	2	20034107
Pubmed	A high level of KLF12 causes folic acid-resistant neural tube defects by activating the Shh signaling pathway in mice†.	NKX2-2 FOXA2	1.44e-04	7	92	2	34104947
Pubmed	The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.	IRS2 FOXA2	1.44e-04	7	92	2	12488434
Pubmed	Hypomorphic Smo mutant with inefficient ciliary enrichment disrupts the highest level of vertebrate Hedgehog response.	NKX2-2 FOXA2	1.44e-04	7	92	2	29571613
Pubmed	Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter.	FOXD3 FOXA2	1.44e-04	7	92	2	7958446
Pubmed	Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton.	ENAH VASP	1.44e-04	7	92	2	10747096
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CUL4A TRNT1 RAB17 COL26A1 SEPTIN9 ENAH RBM5 ECPAS ZSWIM4 ARHGEF26 CCDC57 NXPH4 PDZD2	1.48e-04	1489	92	13	28611215
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ZGPAT FLNC KCNG1 TLN1 MEX3D TRMT1 CC2D1A IRS2 SLC52A2 SH2B2 SOWAHB	1.63e-04	1105	92	11	35748872
Pubmed	The PARP superfamily.	PARP14 PARP15	1.92e-04	8	92	2	15273990
Pubmed	STELLA collaborates in distinct mesendodermal cell subpopulations at the fetal-placental interface in the mouse gastrula.	RUNX1 FOXA2	1.92e-04	8	92	2	28322735
Pubmed	Rab34 small GTPase is required for Hedgehog signaling and an early step of ciliary vesicle formation in mouse.	NKX2-2 FOXA2	1.92e-04	8	92	2	30301781
Pubmed	TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system.	NKX2-2 FOXA2	1.92e-04	8	92	2	36669111
Pubmed	Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord.	NKX2-2 FOXA2	1.92e-04	8	92	2	34478646
Pubmed	HNF-3 beta as a regulator of floor plate development.	BMP6 FOXA2	1.92e-04	8	92	2	8287471
Pubmed	Ena/VASP Is Required for neuritogenesis in the developing cortex.	ENAH VASP	1.92e-04	8	92	2	17988629
Pubmed	Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor.	ENAH VASP	1.92e-04	8	92	2	10892742
Pubmed	Hoxb1 controls effectors of sonic hedgehog and Mash1 signaling pathways.	NKX2-2 FOXA2	2.46e-04	9	92	2	11076756
Pubmed	Olig2 and Hes regulatory dynamics during motor neuron differentiation revealed by single cell transcriptomics.	NKX2-2 FOXA2	2.46e-04	9	92	2	29389974
Pubmed	Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals.	NKX2-2 FOXA2	2.46e-04	9	92	2	10818213
Pubmed	Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused.	NKX2-2 FOXA2	2.46e-04	9	92	2	16155214
Pubmed	A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage.	GDF5 BMP6	2.46e-04	9	92	2	14660436
Pubmed	Protein kinase A deficiency causes axially localized neural tube defects in mice.	NKX2-2 FOXA2	2.46e-04	9	92	2	11886853
Pubmed	Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact.	ENAH VASP	2.46e-04	9	92	2	15148305
Pubmed	The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice.	NKX2-2 FOXA2	2.46e-04	9	92	2	16647304
Pubmed	Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway.	NKX2-2 FOXA2	2.46e-04	9	92	2	12361967
Pubmed	Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.	ENAH VASP	2.46e-04	9	92	2	14592989
Pubmed	Generation of a Nkx2.2(Cre) knock-in mouse line: Analysis of cell lineages in the central nervous system.	NKX2-2 FOXA2	2.46e-04	9	92	2	25840610
Pubmed	HIV-1 Vpr induces the degradation of ZIP and sZIP, adaptors of the NuRD chromatin remodeling complex, by hijacking DCAF1/VprBP.	CUL4A ZGPAT	2.46e-04	9	92	2	24116224
Pubmed	Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis.	NKX2-2 FOXA2	2.46e-04	9	92	2	37943875
Pubmed	An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth.	NKX2-2 FOXA2	2.46e-04	9	92	2	25370275
Pubmed	Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation.	NKX2-2 FOXA2	2.46e-04	9	92	2	10725236
Pubmed	Gene and cluster-specific expression of the Iroquois family members during mouse development.	GDF5 IRX4	2.46e-04	9	92	2	11520674
Pubmed	The loss of Hh responsiveness by a non-ciliary Gli2 variant.	NKX2-2 FOXA2	2.46e-04	9	92	2	25834022
Pubmed	Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube.	NKX2-2 FOXA2	2.46e-04	9	92	2	20516201
Pubmed	Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits.	FLNC TLN1	2.46e-04	9	92	2	11807098
Pubmed	Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.	EPHX2 RECQL4 PAK4 ENAH TRMT1 GPKOW	2.51e-04	330	92	6	21044950
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	EPHX2 FLNC IRS2 ELN SH2B2	2.68e-04	214	92	5	22199357
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	FLNC RTCB POLDIP3 SEPTIN9 PRMT5 GART ENAH ECPAS NLRC3	2.96e-04	809	92	9	32129710
Cytoband	8q24.3	GSDMD RECQL4 SLC52A2 ZC3H3 MFSD3	3.61e-06	113	93	5	8q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr8q24	PHF20L1 GSDMD RECQL4 SLC52A2 ZC3H3 MFSD3	8.87e-05	355	93	6	chr8q24
Cytoband	3p21.3	VILL RBM5 ACKR2	2.41e-04	59	93	3	3p21.3
Cytoband	3q21.1	PARP14 PARP15	7.53e-04	20	93	2	3q21.1
Cytoband	20q13.3	ZGPAT TCFL5	7.53e-04	20	93	2	20q13.3
Cytoband	7q22	LRCH4 SH2B2	2.72e-03	38	93	2	7q22
GeneFamily	ENAH/VASPs	ENAH VASP	3.58e-05	3	63	2	946
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	ZGPAT RBM5 GPKOW	5.92e-05	22	63	3	579
GeneFamily	Zinc fingers\|Zinc fingers PARP-type\|Poly(ADP-ribose) polymerases	PARP14 PARP15	1.57e-03	17	63	2	684
Coexpression	MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3	EGLN3 BMP6 TFCP2L1 EYA4 PDE8A COL26A1 ID3 SP5 NKX2-2 RRAD LTB4R2 RUNX1 PARP14 ARHGEF26 NXPH4 SOWAHB	9.52e-07	1074	92	16	M1941
Coexpression	NIKOLSKY_BREAST_CANCER_8Q23_Q24_AMPLICON	PHF20L1 GSDMD RECQL4 SLC52A2 ZC3H3 MFSD3	1.96e-05	157	92	6	M17936
Coexpression	MIKKELSEN_MCV6_HCP_WITH_H3K27ME3	GRIP1 FOXD3 BMP6 PDE8A TTC9B AIRE RRAD ALOX12B IRX4	2.39e-05	438	92	9	M1954
Coexpression	MIKKELSEN_MCV6_HCP_WITH_H3K27ME3	GRIP1 FOXD3 BMP6 PDE8A TTC9B AIRE RRAD ALOX12B IRX4	2.48e-05	440	92	9	MM832
ToppCell	Control-Myeloid-TRAM3\|Control / Disease group,lineage and cell class （2021.01.30）	GBP4 RTCB TLN1 PARP14 VASP LACTB IL27	1.91e-07	197	93	7	733ff40039d67e561c2ded7c9bd0b4353101741e
ToppCell	BAL-Control-Myeloid-TRAM-TRAM3\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	GBP4 RTCB TLN1 PARP14 VASP LACTB IL27	1.91e-07	197	93	7	4416efdbd9c4ac3356a5dff2d535c2d7383376a9
ToppCell	BAL-Control-Myeloid-TRAM-TRAM3-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GBP4 RTCB TLN1 PARP14 VASP LACTB IL27	1.91e-07	197	93	7	0f1c4a328968b32874e6ebb0803e665adcbbc450
ToppCell	BAL-Control-Myeloid-TRAM-TRAM3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GBP4 RTCB TLN1 PARP14 VASP LACTB IL27	1.91e-07	197	93	7	aafe0cd697b0b7f0756596148e0906443fdf8ef7
ToppCell	BAL-Control-Myeloid-TRAM-TRAM3-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GBP4 RTCB TLN1 PARP14 VASP LACTB IL27	1.91e-07	197	93	7	e131634bc67e0bd31a938a8e8df8dc752e1d0f47
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-CR-CR_Lhx5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ANKRD35 GDF5 ELN ARHGEF26 NXPH4	1.03e-06	86	93	5	2990429ed4438f41ff03f4a9cae8863a528fdd81
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-CR\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ANKRD35 GDF5 ELN ARHGEF26 NXPH4	1.03e-06	86	93	5	97467708c90a4bd49deafe3e2ec495c56b448ce1
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLNC EYA4 ENAH JPH2 ELN RRAD	2.77e-06	188	93	6	4d1e5f85342ae550086609d7680e32730b78b5d2
ToppCell	Mesenchymal-airway_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	FLNC EYA4 ENAH JPH2 ELN RRAD	2.94e-06	190	93	6	645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNG2 EGLN3 TRNT1 RRAD RUNX1	1.69e-05	152	93	5	87a7116d0064a6051bdf28ce1e48bfc168273e66
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D122\|Adult / Lineage, Cell type, age group and donor	FLNC ENAH JPH2 ELN RRAD	2.16e-05	160	93	5	fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RAB17 KCNK16 FOXA2 ALOX12B FAAH2	3.22e-05	174	93	5	3503c7dec498597f76a86dbd5e4bb2311e743bde
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	EME1 BMP6 GBP4 ELN SHANK3	3.31e-05	175	93	5	90302e8a44858ef3b2a165b88284d4788d591a99
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c12-MKI67-TYROBP\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ANKRD35 EME1 MEX3D RECQL4 RRAD	4.10e-05	183	93	5	54782c2e23bbeca5b683aa931393b1118da4aa37
ToppCell	E15.5-Epithelial-airway_epithelial_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RAB17 VILL ENAH RUNX1 FOXA2	4.43e-05	186	93	5	bb2c7af3b1d8478c49a8626dbfd6c92c5e7adc4a
ToppCell	E15.5-Epithelial-airway_epithelial_cell-club_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RAB17 VILL ENAH RUNX1 FOXA2	4.43e-05	186	93	5	86c809b99088d3d6c8f87785797c4beefdcddbe7
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLNC EYA4 JPH2 ELN RRAD	4.66e-05	188	93	5	c29aaae3c5bb7cd6b9b3defd4d27afde3af19ba0
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma-chondrocyte\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	GDF5 EYA4 ENAH ELN PDZD2	4.66e-05	188	93	5	c9270517e6940e9793586f67f02431210552f278
ToppCell	CV-Severe-5\|Severe / Virus stimulation, Condition and Cluster	EPHX2 EGLN3 TRMT1 ID3 FAAH2	5.02e-05	191	93	5	d04f93fc85c882260ca4d5b4768504fbf8a47984
ToppCell	CV-Severe-5\|CV / Virus stimulation, Condition and Cluster	EPHX2 EGLN3 TRMT1 ID3 FAAH2	5.28e-05	193	93	5	d87fcd4553b6198c3128685b73ffd1b1ae88fbb5
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GDF5 FLNC KCNG1 ENAH JPH2	5.28e-05	193	93	5	0256e8fe4a47f2e2a43ef9d19bfc047d20806d69
ToppCell	CD8+_Memory_T_cell-CV-5\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	EPHX2 EGLN3 TRMT1 ID3 FAAH2	5.41e-05	194	93	5	5d644fe6da99b023eee100882ee7b71af4f3814a
ToppCell	CV-Moderate-5\|Moderate / Virus stimulation, Condition and Cluster	EPHX2 EGLN3 TRMT1 ID3 FAAH2	5.54e-05	195	93	5	646d06ac3fa20acb172735c88cf45e01d212cebf
ToppCell	CV-Moderate-5\|CV / Virus stimulation, Condition and Cluster	EPHX2 EGLN3 TRMT1 ID3 FAAH2	5.54e-05	195	93	5	7a0bb304c659dd108b75d0c5d19eca5e63cf856d
ToppCell	Cerebellum-Endothelial\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GSDMD TLN1 ID3 ELN PARP14	5.54e-05	195	93	5	2192fd9b4682054776f0716933aed5a4a9412657
ToppCell	CV-Healthy-5\|Healthy / Virus stimulation, Condition and Cluster	EPHX2 EGLN3 TRMT1 ID3 FAAH2	5.68e-05	196	93	5	f121b009d64704177f73f2da3848f0ad6ed6bf1f
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLNC ENAH ID3 IRS2 ELN	5.68e-05	196	93	5	45d1c0a962c4221c17393ee5566961d1deebf442
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	EGLN3 BMP6 GBP4 ID3 SHANK3	5.82e-05	197	93	5	b2b7f8dc8ca421441e4c99c4f5d18fbc1668d79f
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EGLN3 FLNC TLN1 ENAH JPH2	5.82e-05	197	93	5	5a63c2b824c7d0dbbc706e408459c9b9fe65daaa
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PAK4 CLDN19 RRAD CCDC57 ZC3H3	6.10e-05	199	93	5	bbb4798d6a24e756fea744a151ba67c1bafbac9a
ToppCell	distal-2-mesenchymal-Airway_Smooth_Muscle\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FLNC ENAH JPH2 ELN RRAD	6.10e-05	199	93	5	af226a6c50747dad9ca696463e715913b3ac17c0
Drug	Articaine hydrochloride [23964-57-0]; Down 200; 12.4uM; MCF7; HT_HG-U133A	BMP6 GART CC2D1A IRS2 RUNX1 ZC3H3 TRIM3	1.33e-05	197	90	7	6517_DN
Drug	Ranitidine hydrochloride [66357-59-3]; Down 200; 11.4uM; PC3; HT_HG-U133A	ZNF8 POLDIP3 TLN1 GART CC2D1A IRS2 TSPYL4	1.37e-05	198	90	7	2088_DN
Drug	Bezafibrate [41859-67-0]; Down 200; 11uM; HL60; HT_HG-U133A	PHF20L1 PAK4 RBM5 TIMM17A ECPAS ZC3H3 VASP	1.37e-05	198	90	7	1275_DN
Drug	Methapyrilene hydrochloride [135-23-9]; Up 200; 13.4uM; MCF7; HT_HG-U133A	PRR36 POLDIP3 IRS2 ELN RUNX1 ECPAS CCDC57	1.42e-05	199	90	7	4990_UP
Disease	tauopathy (implicated_via_orthology)	ENAH VASP	3.98e-04	10	89	2	DOID:680 (implicated_via_orthology)
Disease	anterior thigh muscle volume	GDF5 BMP6	3.98e-04	10	89	2	EFO_0020935
Disease	Sjogren's syndrome (implicated_via_orthology)	AIRE ID3	1.19e-03	17	89	2	DOID:12894 (implicated_via_orthology)
Disease	reasoning	EGLN3 MAP3K9	1.49e-03	19	89	2	EFO_0004350
Disease	eotaxin measurement	EGLN3 ACKR2 PDZD2	1.84e-03	80	89	3	EFO_0008122
Disease	Rheumatoid Arthritis	GDF5 BMP6 GART RUNX1	1.93e-03	174	89	4	C0003873
Disease	Back pain	GDF5 KCNG2 KCNG1	2.34e-03	87	89	3	HP_0003418

Protein segments in the cluster

Peptide	Gene	Start	Entry
RPAGQGRALKIAAAL	ACKR2	241	O00590
LAAPGQAKIAGGAAV	GSDMD	96	P57764
GQDKGGLPLAALVLS	CFAP46	2686	Q8IYW2
NPIAKGRVAIAGGAL	CLDN19	111	Q8N6F1
PLLLGAQRRAVANGG	ARHGEF26	81	Q96DR7
ARGEPLGALGGEKAL	ANKRD35	591	Q8N283
LRDGQLAGPRAGVSK	EGLN3	56	Q9H6Z9
GPKPLVRAKGAQGAA	AIRE	251	O43918
ALPAGAGLLDKVGRS	C17orf113	606	A0A1B0GUU1
ALARAGAAGALPAQR	NXPH4	76	O95158
LRGDAAVALNKGPAR	RAB17	191	Q9H0T7
GAARELLALPKAGGK	IRX4	501	P78413
DSLLKPGLRAVVGGA	LRCH4	431	O75427
LLGAPGVGKSALARI	RRAD	96	P55042
LGGGPLSRAFLQKAG	PARP15	116	Q460N3
ANAEAAARAPKGGGL	JPH2	206	Q9BR39
AARAPKGGGLFQRGA	JPH2	211	Q9BR39
KPAAPGGGRAAQLKL	GDF5	251	P43026
LRGNSIGPQGAKALA	NLRC3	701	Q7RTR2
LRGNAIGVAGAKALA	NLRC3	981	Q7RTR2
LLSLRQGCGAKAAPG	KCNK16	266	Q96T55
ALGVKLAGGLRGAAP	LACTB	51	P83111
PAKGAAGQRTIAALL	ECPAS	1241	Q5VYK3
AAGPGGTKLLERAGL	KCNG2	271	Q9UJ96
AKASRGGLPSLANGQ	PDZD2	2261	O15018
GQKTAALPRTRGAGL	PDE8A	36	O60658
ALGDANKVSARGPGL	FLNC	371	Q14315
RATRSKAGGLPGAAQ	MEX3D	251	Q86XN8
NSLRPKGLGLGANLT	GPKOW	196	Q92917
NRLAGKRNGFPLGST	GBP4	71	Q96PP9
LLVDGAAAGRRKPGA	KCNG1	316	Q9UIX4
GAGQAGLPAAVAGLL	MFSD3	91	Q96ES6
APIEAQVRLKGAGLG	RBM5	771	P52756
GGLAAALSKAAGPEL	PARP14	831	Q460N5
GRGSKVALLPAGGAL	IRS2	411	Q9Y4H2
APILRAAGLLGANSA	DERPC	276	P0CG12
AGPAGLSAAVRLKQL	ETFDH	76	Q16134
KNNVGGLLGPAKRDA	EYA4	496	O95677
ALPRGLLNDAFQKGG	EPHX2	31	P34913
IIIGAGPAGLAAARQ	KDM1B	386	Q8NB78
GRTNGLTKPAALAAA	CUL4A	16	Q13619
ERKGLLPGALGSALQ	IL27	176	Q8NEV9
LPAAAAAAAGGQLLG	BMP6	31	P22004
PGRGAAAARQLGLLV	CC2D1A	11	Q6P1N0
AGPVSSGLALRKLGD	CCDC57	651	Q2TAC2
AGRGPLVNASLRAAK	PRMT5	366	O14744
ALLKGAGAIPLGITN	FAAH2	161	Q6GMR7
GRAVLLNEGGLSAKG	ALOX12B	441	O75342
LEGGKPLSGLLNALA	COMMD1	6	Q8N668
KRARIPSGKAGAANG	CUTC	11	Q9NTM9
CQAKLLSGGLGGPNR	C19orf54	186	Q5BKX5
SLAIARGRGKGPAAE	ID3	21	Q02535
NRPLTGLAAAIAGAK	ENAH	386	Q8N8S7
AGGVKVDLAGRGLAL	EME1	466	Q96AY2
GKPRVSNLRQGGIAA	GRIP1	76	Q9Y3R0
KAQLRAAAGLGAGIP	ELN	566	P15502
VLLLNLGPRAAGAQG	MENT	11	Q9BUN1
KRGGAQPDGVLAALL	COL26A1	411	Q96A83
EFARGGPLNRVLSGK	MAP3K9	221	P80192
LGRKAAAFGSQLGPG	FOXD3	326	Q9UJU5
AAKGRLNARPGVGGV	POLDIP3	16	Q9BY77
AGLASGAKLAAGRPF	PAK4	191	O96013
IADGRGAPAAAGISK	PHF20L1	516	A8MW92
GAQGPLGAGIALACK	PDHA2	166	P29803
RGGLGELKGTPAAAL	FOXA2	316	Q9Y261
LGAPDAGAALAGKLR	RUNX1	31	Q01196
AKKRGLPQLGTLGAG	RTCB	211	Q9Y3I0
LQRLGKASGVPSGRA	TRMT1	356	Q9NXH9
IAGGAVRDLLNGVKP	TRNT1	61	Q96Q11
AAAAALQRGLVLGPS	SP5	231	Q6BEB4
ARLGSAVKISLPDGG	SPATA5L1	41	Q9BVQ7
EGALAKLGGAGQAAR	LTB4R2	256	Q9NPC1
ANLKGTLQAGPALGR	RECQL4	111	O94761
GELAPKNLRGALGVV	SLC2A5	151	P22732
VLGAAGAVGRKPLAE	PRR36	46	Q9H6K5
GRPALLAAGVAIQVG	SLC52A2	401	Q9HAB3
NAGAIGPSRFGLKRA	SEPTIN9	121	Q9UHD8
PAKRAGPLGQGALDA	NKX2-2	41	O95096
GPADGIRLFNAIKGR	TFCP2L1	351	Q9NZI6
DRGKLRNPAGGLSVS	SOWAHB	431	A6NEL2
KLIGLQRVASPAGAG	SMCR8	781	Q8TEV9
LNRLRPVASGGGKAQ	ZC3H3	576	Q8IXZ2
KPGLEARLGAGAAGL	SHANK3	856	Q9BYB0
EGGSGRPLLQAAKGL	TLN1	601	Q9Y490
RPLLQAAKGLAGAVS	TLN1	606	Q9Y490
GGNKLPLAQTGGLAA	TSPYL4	6	Q9UJ04
KAAQLVLAGGPRNHG	SH2B2	426	O14492
APLAAGIVGNLRSAG	GART	76	P22102
PGNGRAGAVALQALK	VILL	746	O15195
GALTGAILAARNGPV	TIMM17A	96	Q99595
GLLARGNLGAKSGPS	ZACN	316	Q401N2
GGAKAGQPESRALAL	ZNF8	526	P17098
GFLVQRKASALGPGA	VSIG10L2	631	P0DP72
RLNSALLAAAGPGAG	TCFL5	76	Q9UL49
ALLQLKAAQGARPSG	TTC9B	91	Q8N6N2
KLQGQAPGALEAGAA	ZGPAT	421	Q8N5A5
GRLPQLSAAIALVGG	TRIM3	171	O75382
AGAPGLAAAIAGAKL	VASP	221	P50552
RKQAGLLLEGGPFSG	ZSWIM4	516	Q9H7M6