Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	M_domain	TNRC6A TNRC6C	2.00e-05	2	84	2	PF12938
Domain	GW182_M_dom	TNRC6A TNRC6C	2.00e-05	2	84	2	IPR026805
Domain	Ago_hook	TNRC6A TNRC6C	5.98e-05	3	84	2	PF10427
Domain	TNRC6_PABC-bd	TNRC6A TNRC6C	5.98e-05	3	84	2	IPR032226
Domain	Argonaute_hook_dom	TNRC6A TNRC6C	5.98e-05	3	84	2	IPR019486
Domain	TNRC6-PABC_bdg	TNRC6A TNRC6C	5.98e-05	3	84	2	PF16608
Domain	CARMIL_C	CARMIL3 CARMIL1	5.98e-05	3	84	2	IPR031943
Domain	CARMIL_C	CARMIL3 CARMIL1	5.98e-05	3	84	2	PF16000
Domain	PKD_channel	PKD1 MCOLN1	1.07e-03	11	84	2	PF08016
Domain	PKD1_2_channel	PKD1 MCOLN1	1.07e-03	11	84	2	IPR013122
Domain	Leu-rich_rpt	LRFN2 CARMIL3 CARMIL1 PKD1 LRIT1 LRCH3	1.39e-03	271	84	6	IPR001611
Domain	UBA-like	TNRC6A DMRTA1 TNRC6C	3.00e-03	64	84	3	IPR009060
Domain	-	LRFN2 CARMIL3 CARMIL1 PKD1 LRIT1 LRCH3	3.25e-03	321	84	6	3.80.10.10
Domain	L_dom-like	LRFN2 CARMIL3 CARMIL1 PKD1 LRIT1 LRCH3	3.61e-03	328	84	6	IPR032675
Pubmed	A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing.	EIF4G1 TNRC6A TNRC6C	9.61e-07	8	91	3	24768540
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TEAD2 TNRC18 TBKBP1 ZNF296 PCNX3 EIF4G1 PKD1 KDM3B LTK TNRC6C SNAPC4 D2HGDH RAB11FIP3	6.06e-06	1105	91	13	35748872
Pubmed	Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.	EIF4G1 TNRC6A TNRC6C	6.18e-06	14	91	3	19716330
Pubmed	Pax1/E2a double-mutant mice develop non-lethal neural tube defects that resemble human malformations.	TCF3 PAX1	6.77e-06	2	91	2	16315099
Pubmed	Paraxis is a basic helix-loop-helix protein that positively regulates transcription through binding to specific E-box elements.	TCF3 PAX1	2.03e-05	3	91	2	15226298
Pubmed	Cell Migration and Invadopodia Formation Require a Membrane-binding Domain of CARMIL2.	CARMIL3 CARMIL1	2.03e-05	3	91	2	26578515
Pubmed	Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.	TNRC6A TNRC6C	2.03e-05	3	91	2	34108231
Pubmed	Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.	TNRC6A TNRC6C	2.03e-05	3	91	2	16880270
Pubmed	Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.	TNRC6A TNRC6C	2.03e-05	3	91	2	31670606
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	KCNB1 PRRT3 SAFB2 PRKAR2B PODXL2 AGAP2	3.35e-05	231	91	6	16452087
Pubmed	The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets.	TNRC6A TNRC6C	4.05e-05	4	91	2	23172285
Pubmed	Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.	TNRC6A TNRC6C	4.05e-05	4	91	2	21063388
Pubmed	Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein.	TNRC6A TNRC6C	4.05e-05	4	91	2	20181956
Pubmed	Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation.	ZC3H12A TNRC6A	4.05e-05	4	91	2	26134560
Pubmed	Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis.	TEAD2 TCF3	4.05e-05	4	91	2	36400009
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	SHANK1 TNRC18 FAM171A2 KCNB1 EMC4 MBOAT7 TNRC6A PRKAR2B PLPPR3 SHROOM2 NDUFV1 AGAP2	4.19e-05	1139	91	12	36417873
Pubmed	Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2.	TCF3 PKD1	6.74e-05	5	91	2	16311606
Pubmed	Distinct roles for CARMIL isoforms in cell migration.	CARMIL3 CARMIL1	6.74e-05	5	91	2	19846667
Pubmed	Functional dissection of the human TNRC6 (GW182-related) family of proteins.	TNRC6A TNRC6C	1.41e-04	7	91	2	19470757
Pubmed	Positive regulation of myogenic bHLH factors and skeletal muscle development by the cell surface receptor CDO.	TCF3 PAX1	1.41e-04	7	91	2	15572127
Pubmed	Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily.	GDF7 PAX1	1.41e-04	7	91	2	8145850
Pubmed	The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.	TNRC6A TNRC6C	1.41e-04	7	91	2	19383768
Pubmed	A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc).	PTCH2 PAX1	2.41e-04	9	91	2	11784021
Pubmed	HEB and E2A function as SMAD/FOXH1 cofactors.	TCF3 FOXH1	3.01e-04	10	91	2	21828274
Pubmed	miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT.	TNRC6A TNRC6C	3.01e-04	10	91	2	21984185
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	KCNB1 PRRT3 PRKAR2B TRAPPC14 MCOLN1 AGAP2	3.09e-04	347	91	6	17114649
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	SHANK1 DHX36 MBOAT7 CARMIL1 RBP3 EIF4G1 PRKAR2B SHROOM2 VIRMA NDUFV1 LRCH3 AGAP2	3.52e-04	1431	91	12	37142655
Pubmed	miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs.	TNRC6A TNRC6C	3.67e-04	11	91	2	21984184
Pubmed	Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry.	DHX36 SAFB2 AGAP2	4.12e-04	55	91	3	18570454
Pubmed	Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.	MGMT SHB C9orf50	4.34e-04	56	91	3	23934736
Pubmed	Glutamatergic Dysfunction and Synaptic Ultrastructural Alterations in Schizophrenia and Autism Spectrum Disorder: Evidence from Human and Rodent Studies.	SHANK1 LRFN2	5.18e-04	13	91	2	33374598
Pubmed	Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor.	PSMB4 PTCH2 TUT1	6.73e-04	65	91	3	28276505
Pubmed	Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice.	RIPPLY3 PAX1	6.95e-04	15	91	2	21177346
Pubmed	PDZ-Containing Proteins Targeted by the ACE2 Receptor.	SHANK1 SHROOM2	6.95e-04	15	91	2	34835087
Pubmed	GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.	TNRC6A TNRC6C	6.95e-04	15	91	2	21981923
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	TCF3 TNRC6A CCDC120 TNRC6C	6.98e-04	152	91	4	38360978
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	LRFN2 DDN TNRC6C VIRMA TET3 SNX19	7.14e-04	407	91	6	12693553
Pubmed	Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure.	KCNB1 GRIN2C	8.98e-04	17	91	2	24086760
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SHANK1 FAM171A2 KCNB1 EIF4G1 SAFB2 DDN PRKAR2B VIRMA AGAP2	9.51e-04	963	91	9	28671696
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MGMT STC2 CARMIL1 EIF4G1 SAFB2 KDM3B SNAPC4 VIRMA	9.72e-04	774	91	8	15302935
Pubmed	Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus.	GDF7 PTCH2	1.01e-03	18	91	2	19570847
Pubmed	Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.	TCF3 TNRC6C CPOX	1.06e-03	76	91	3	27542412
Pubmed	Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors.	TEAD2 PAX1	1.12e-03	19	91	2	20596238
Pubmed	FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues.	GDF7 PAX1	1.25e-03	20	91	2	15105374
Pubmed	A molecular genetic linkage map of mouse chromosome 2.	PAX1 LTK	1.25e-03	20	91	2	1970329
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	TCF3 SHB TNRC6A CCDC120	1.31e-03	180	91	4	35198878
Pubmed	Temporomandibular joint formation requires two distinct hedgehog-dependent steps.	GDF7 PTCH2	1.38e-03	21	91	2	19815519
Pubmed	Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm.	TNRC6A TNRC6C	1.51e-03	22	91	2	22187428
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	ZNF296 GPR153 EIF4G1 C9orf50 PODXL2 GRIN2C TRAPPC14 SLX4	1.54e-03	832	91	8	36724073
Pubmed	A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection.	KRT23 PSMB4 SAFB2 CCDC61	1.56e-03	189	91	4	31594818
Pubmed	Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung.	TNRC6A TNRC6C	1.65e-03	23	91	2	28811219
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	TNRC18 TNRC6A	1.65e-03	23	91	2	9225980
Pubmed	The sequence and analysis of duplication-rich human chromosome 16.	NHLRC4 SLX4 RAB11FIP3	1.73e-03	90	91	3	15616553
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TCF3 TNRC18 LRFN2 TBKBP1 CARMIL1 SHB TNRC6C SHROOM2 TET3 PLBD2 LRCH3	1.75e-03	1489	91	11	28611215
Pubmed	Transcriptomic analysis of the upper lip and primary palate development in mice.	GDF7 PAX1	1.80e-03	24	91	2	36685938
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SHANK1 RIPPLY3 PSMB4 EIF4G1 PKD1 SPRED1 SHROOM2 TARBP1 SLX4 AGAP2	1.96e-03	1285	91	10	35914814
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	RIPPLY3 SAFB2 SPRED1 IRGQ SHROOM2 D2HGDH IKBIP SLX4 RAB11FIP3	2.14e-03	1084	91	9	11544199
Pubmed	Same but different - Molecular comparison of human KTI12 and PSTK.	FAM171A2 TNRC6C	2.28e-03	27	91	2	33417976
Pubmed	Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ.	KRT23 PTCH2	2.45e-03	28	91	2	32674056
GeneFamily	Ataxins\|Trinucleotide repeat containing	TNRC18 TNRC6A TNRC6C	4.39e-05	25	50	3	775
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEAD2 ZC3H12A C9orf50 ADAM11 CHST2	1.69e-06	97	91	5	16947da747504c2edb9f2e7ee6f05babda0fae60
ToppCell	wk_15-18-Hematologic-Myeloid-Basophil\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PCNX3 MBOAT7 SHB SAFB2 CCDC120 AGAP2	2.44e-06	188	91	6	3638d85452de15a060146628fbbad9d2a36feb13
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Mesenchymal-Mesoderm\|10w / Sample Type, Dataset, Time_group, and Cell type.	ZNF296 KCNB1 SYNPO2L PTCH2 SNX19 IKBIP	3.48e-06	200	91	6	9ef226ebb0a7cdb9431e2fa65faa2a7d67da590d
Drug	AH23848 hemicalcium salt hydrate; Up 200; 1uM; MCF7; HT_HG-U133A	TCF3 MGMT MBOAT7 RIPPLY3 SAFB2 NIPAL2 SNAPC4 TRAPPC14	1.07e-06	195	90	8	6903_UP
Disease	stem Cell Growth Factor-beta measurement	SHANK1 RAB11FIP3	7.96e-05	5	84	2	EFO_0802090
Disease	stem cell growth factor-alpha measurement	SHANK1 RAB11FIP3	1.67e-04	7	84	2	EFO_0020754
Disease	bipolar disorder	RASIP1 MCTP1 KCNB1 CARMIL1 KDM3B DDN SNX19 TARBP1	2.41e-04	577	84	8	MONDO_0004985
Disease	developmental disorder of mental health (implicated_via_orthology)	TCF3 GIGYF1 GRIN2C	3.73e-04	49	84	3	DOID:0060037 (implicated_via_orthology)
Disease	hypertrophic cardiomyopathy	SYNPO2L PKD1 ALPK3	2.33e-03	92	84	3	EFO_0000538
Disease	atopic eczema, psoriasis	RASIP1 MGMT	4.74e-03	36	84	2	EFO_0000274, EFO_0000676

Protein segments in the cluster

Peptide	Gene	Start	Entry
DGHTQPGLRSWGGLG	C1orf167	381	Q5SNV9
RAFTWLGGSGGLPTN	ARSH	81	Q5FYA8
LGSGGSGDGPSVSWS	CCDC61	371	Q9Y6R9
ARGSGDWRIPGGGAA	C9orf50	46	Q5SZB4
GAAAAGRGPGAGAWR	ALPK3	171	Q96L96
GRGPGAGAWRTGEAA	ALPK3	176	Q96L96
GLGTQGPAGALRWGG	ADAM11	21	O75078
GGGKGAGSRLSWPES	AGAP2	201	Q99490
APGGTGWRESLGLGE	DDN	406	O94850
LSGPGLGRGHWTAAG	RCC1L	16	Q96I51
AGGPGTPGGAQRWAS	RASIP1	106	Q5U651
GAAADGGARWSAGPA	RAB11FIP3	61	O75154
GSRSGLWAGGPAPGQ	PSMB4	6	P28070
PGAARGGRGLWTVGG	KIRREL3-AS3	31	Q8N7Y1
AGSLVAGWSGGGPTI	NOBOX	321	O60393
RGGGDPWTNGSGLAL	MCOLN1	151	Q9GZU1
LNGGGALNGPGSWGA	PODXL2	571	Q9NZ53
AGPGFGPGSWSRSLD	LRCH3	36	Q96II8
NAPARGSGAGSRWSG	MCTP1	66	Q6DN14
PGGRSSGGHRASLWG	FOXH1	261	O75593
SGGGSSGLGLWEDTP	GIGYF1	831	O75420
GSGGDRGAAPGSHWS	DNAAF2	106	Q9NVR5
LLLGVWGPSGRTGGQ	LINC02872	16	A2RU37
WGPSGRTGGQRKGAS	LINC02872	21	A2RU37
LGGSSGLAGAWLKGA	MGMT	181	P16455
GLAGAWLKGAGATSG	MGMT	186	P16455
GLGGSQPTASGSWEG	CARMIL3	946	Q8ND23
RGLPRSGGGTGWGEL	CCDC120	451	Q96HB5
AGGGGGWTSRAPSPQ	LTK	271	P29376
GWGPRSSLSGSGDGR	PCNX3	1876	Q9H6A9
RGGAPGGGARLSPWL	PDE3A	116	Q14432
SASWGEPGGLRAAGG	GPR153	566	Q6NV75
QRSSGGGDHWGEGPL	RIPPLY3	161	P57055
GGEASRGPWKGGNAS	KDM3B	316	Q7LBC6
PSASFHGAGGGWGRP	KRT23	11	Q9C075
GGSWGSGRSSPLLGG	KRT23	56	Q9C075
GPGLKRWGAAAVGLG	MBOAT7	26	Q96N66
GSAAGFRASIWGPAG	LCA10	36	Q71F78
GSARQPLGSLGGWTG	NHLRC4	31	P0CG21
GGKTPVARSSGGGGW	IKBIP	26	Q70UQ0
GSPGALWARTGGGGE	LRIT1	356	Q9P2V4
GEGWGAGRAAPVSGS	FAM171A2	601	A8MVW0
WEGAAAAAAGPGAGG	PAX1	16	P15863
APEVGWRGALGASGG	KCNB1	621	Q14721
SPGGKARPAGNTGAW	C21orf58	36	P58505
HQNWGRDGGPRSSGG	DHX36	6	Q9H2U1
CSGLSWPPGGRASGG	DMRTA1	161	Q5VZB9
APGGRLSWGKGSSGG	EIF4G1	1086	Q04637
RTWGDLGAAAGGGTP	PRKAR2B	56	P31323
GGASWAGASGLLSSP	CARMIL1	741	Q5VZK9
KWAIELSGPGGGSRG	EMC4	16	Q5J8M3
SFTRPGRGSWLGKGG	FAM135B	181	Q49AJ0
GLGHGSTSRGGPWVG	CPOX	61	P36551
TLLLLSGLGAPGGWG	IZUMO2	6	Q6UXV1
AWGSAASLGRGPQGG	PRRT3	771	Q5FWE3
AWLLRGAPGAAGSWG	D2HGDH	11	Q8N465
WPAGGAAATGGLGYR	IRGQ	581	Q8WZA9
GLWLGALAGGPGRGC	PKD1	16	P98161
LSGGAPWGFRLHGGA	SYNPO2L	11	Q9H987
GPAWGQSGFLAGGLH	TMEM105	86	Q8N8V8
PGILAWGRGSGNNGV	TNRC6C	306	Q9HCJ0
AGDPLGGACAGGRTW	SHB	196	Q15464
RGRGGAGFPTGLKWS	NDUFV1	86	P49821
YGAPGAGNGSLSGDW	NIPAL2	26	Q9H841
PQGGGLRWGASSSLP	PTCH2	1136	Q9Y6C5
ALRRLGFGWPGGGGS	GDF7	246	Q7Z4P5
LSGGAPWGFTLKGGR	SHROOM2	31	Q13796
GRWRAGLGGGTQEGP	SHROOM2	661	Q13796
LNWGPSGEEAGAGGS	TEAD2	306	Q15562
EGLSASPWPGSGGLA	SLX4	621	Q8IY92
FGGSSAAGGALPWAR	SHANK1	1881	Q9Y566
PLGAAAGAAGGSWGR	CHST2	91	Q9Y4C5
GGPALAGSGRWSADP	TNRC18	781	O15417
PGAGRSPWGRAGSLA	ZC3H12A	536	Q5D1E8
GGRGAGSQSLPRGWS	nan	141	Q6ZSN1
LGPLGGGSQTWEGSG	RBP3	286	P10745
GGSGLEDRPSSGSWG	TCF3	46	P15923
GGGPGLGSRGAWAEL	TRAPPC14	61	Q8WVR3
RLWGRAGGPAGAEGS	PLPPR3	101	Q6T4P5
WAQGRGLSGSGPLLS	TUT1	416	Q9H6E5
GAVGRFVGWGPAGLA	WDR97	161	A6NE52
DSSGGWLPLGGSGLS	SPRED1	26	Q7Z699
VGGLGAQGPSGSSEW	STC2	276	O76061
ARWQGGERGLSGPSG	SAFB2	876	Q14151
LGPGAWGHSGSSGSF	TET3	1301	O43151
LGGWLGSSLAGVASG	SNX19	61	Q92543
LWSGAGLCSGLGARG	nan	146	Q8N1X5
GAGAWLGGPAASLSP	SNAPC4	586	Q5SXM2
SGLAGAIPAPGGRWA	PLBD2	36	Q8NHP8
WGGLAAPGASLGSGR	TARBP1	211	Q13395
SLVTVSWGGPNGAGG	PVRIG	71	Q6DKI7
SWGGPNGAGGTTLAV	PVRIG	76	Q6DKI7
LALRGGSGLSHAGWP	TBKBP1	201	A7MCY6
TQGRAGAGLAAGSPW	VWA7	861	Q9Y334
ASRGRGGLGPSWASA	VIRMA	1771	Q69YN4
GANSGGSRRGWGTPA	TNRC6A	591	Q8NDV7
GLGGAGGLAGLTFPW	TLX2	106	O43763
SGAQAGPGGDTWGAI	ZNF296	341	Q8WUU4
SLGSGEAAGLGRAPW	LRFN2	626	Q9ULH4
AWGPLGHRGRTLGLG	GRIN2C	1181	Q14957