Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	arylsulfatase activity	ARSJ GALNS	1.96e-04	14	30	2	GO:0004065
GeneOntologyMolecularFunction	sulfuric ester hydrolase activity	ARSJ GALNS	2.93e-04	17	30	2	GO:0008484
Domain	Sulfatase_CS	ARSJ GALNS	2.95e-04	16	30	2	IPR024607
Domain	SULFATASE_1	ARSJ GALNS	3.34e-04	17	30	2	PS00523
Domain	SULFATASE_2	ARSJ GALNS	3.34e-04	17	30	2	PS00149
Domain	Sulfatase	ARSJ GALNS	3.76e-04	18	30	2	PF00884
Domain	Sulfatase_N	ARSJ GALNS	3.76e-04	18	30	2	IPR000917
Domain	Alkaline_phosphatase_core	ARSJ GALNS	1.13e-03	31	30	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ARSJ GALNS	1.13e-03	31	30	2	IPR017849
Domain	-	ARSJ GALNS	1.13e-03	31	30	2	3.40.720.10
Domain	zf-C2H2_6	ZNF480 ZNF556 ZNF732	1.37e-02	314	30	3	PF13912
Pubmed	Association of N-acetylgalactosamine-6-sulfate sulfatase with the multienzyme lysosomal complex of beta-galactosidase, cathepsin A, and neuraminidase. Possible implication for intralysosomal catabolism of keratan sulfate.	GALNS CTSA	4.61e-06	4	31	2	8910459
Pubmed	Altered mitochondrial expression genes in patients receiving right ventricular apical pacing.	NDUFA1 CTSA	7.68e-06	5	31	2	27177495
Pubmed	Myosin Va, a Novel Interaction Partner of STXBP1, Is Required to Transport Syntaxin1A to the Plasma Membrane.	STXBP1 HDAC2	2.15e-05	8	31	2	37315734
Pubmed	Development of the mouse neuromuscular junction in the absence of regulated secretion.	STXBP1 SYN3	2.15e-05	8	31	2	12895513
Pubmed	FAM188B enhances cell survival via interaction with USP7.	USP7 SERBP1 IFT172	2.70e-05	65	31	3	29795372
Pubmed	The E3 ligase subunit FBXO45 binds the interferon-λ receptor and promotes its degradation during influenza virus infection.	RNF10 USP7	5.96e-05	13	31	2	36379255
Pubmed	Expression patterns of sulfatase genes in the developing mouse embryo.	ARSJ GALNS	5.96e-05	13	31	2	20503373
Pubmed	Chfr is linked to tumour metastasis through the downregulation of HDAC1.	USP7 HDAC2	9.16e-05	16	31	2	19182791
Pubmed	Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication.	RNF10 ZNF480 STXBP1 PLOD2	1.14e-04	283	31	4	18854154
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	USP7 GPRC5A CTSA HDAC2 CD109	2.74e-04	660	31	5	32780723
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	USP7 AFTPH PLOD2 MTM1	3.43e-04	378	31	4	34315543
Pubmed	The synaptic vesicle cycle.	STXBP1 SYN3	3.52e-04	31	31	2	15217342
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	USP7 BAMBI NDUFA1 GRIN2D ARSJ TIAM2	3.78e-04	1105	31	6	35748872
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	CTSA PLOD2 CD109	4.20e-04	164	31	3	32409323
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	RNF10 USP7 SERBP1 STXBP1 SYN3 HDAC2	4.44e-04	1139	31	6	36417873
Pubmed	Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.	CTSA CD109	5.30e-04	38	31	2	16263699
Pubmed	In Vitro Reconstitution and Analysis of SARS-CoV-2/Host Protein-Protein Interactions.	PLOD2 HDAC2	5.87e-04	40	31	2	37483225
Pubmed	Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1.	USP7 HDAC2	5.87e-04	40	31	2	34585037
Pubmed	PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.	USP7 HDAC2	6.17e-04	41	31	2	22325352
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	USP7 SERBP1 FHL3 CTSA HDAC2	6.92e-04	809	31	5	32129710
Pubmed	The N-terminal domain of the Schaaf-Yang syndrome protein MAGEL2 likely has a role in RNA metabolism.	USP7 SERBP1	7.77e-04	46	31	2	34265304
Pubmed	MLF2 Negatively Regulates P53 and Promotes Colorectal Carcinogenesis.	USP7 SERBP1	8.45e-04	48	31	2	37438558
Pubmed	Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.	STXBP1 SYN3	8.81e-04	49	31	2	20471030
Cytoband	7p22.1	RSPH10B2 RSPH10B	4.68e-04	47	31	2	7p22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr7p22	RSPH10B2 RSPH10B	3.72e-03	134	31	2	chr7p22
GeneFamily	Sulfatases	ARSJ GALNS	2.14e-04	18	22	2	410
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_NONRESPONDER_28DY_UP	ZNF480 SERBP1 AFTPH CLK4 HDAC2	1.80e-06	174	31	5	M40888
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_NONRESPONDER_7DY_UP	USP7 ZNF480 SERBP1 HDAC2	1.49e-05	127	31	4	M40905
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c10-IFNG\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	GRIN2D SYN3 PLOD2 RSPH10B	1.74e-06	126	31	4	d19382597ce5c6546731ac1fd33c7dcb7916b2ea
Disease	Liver Cirrhosis	BAMBI PLOD2 HDAC2	1.57e-04	103	30	3	C0023890
Disease	Fibrosis, Liver	BAMBI PLOD2 HDAC2	1.66e-04	105	30	3	C0239946
Disease	Colorectal Carcinoma	ZNF480 NDUFA1 GALNS FHL3 CD109	6.54e-04	702	30	5	C0009402
Disease	Schizophrenia	ZNF480 GRIN2D STXBP1 SYN3 HDAC2	1.82e-03	883	30	5	C0036341
Disease	APOE carrier status, dementia	BAMBI ZNF732	1.82e-03	62	30	2	EFO_0007659, MONDO_0001627
Disease	Cardiac Hypertrophy	BAMBI HDAC2	3.16e-03	82	30	2	C1383860
Disease	Cardiomegaly	BAMBI HDAC2	3.16e-03	82	30	2	C0018800

Protein segments in the cluster

Peptide	Gene	Start	Entry
AHGLRYQWGGSHSNK	AFTPH	711	Q6ULP2
GSFTGWKRHGAHIYL	GPRC5A	201	Q8NFJ5
HYSGLKHEDKRGGSG	SERBP1	206	Q8NC51
KHEDKRGGSGSHNWG	SERBP1	211	Q8NC51
GHWCNGKRHGKGSIY	RSPH10B	181	P0C881
GHWCNGKRHGKGSIY	RSPH10B2	181	B2RC85
EVGYSTHMVGKWHLG	ARSJ	166	Q5FYB0
YGKWSGGKHHDSRIS	PLOD2	586	O00469
AHKHVAYLWAKSLGG	IFT172	1086	Q9UG01
SGYLKGSGSKHLHYW	CTSA	51	P10619
AGYVSKIVGKWHLGH	GALNS	131	P34059
HRTYTWLKGHQKSNG	CD109	1011	Q6YHK3
LGGGKYVSFEDRHWH	FHL3	231	Q13643
AVEWFKAHGHGRSSG	SDR42E1	346	Q8WUS8
KILSLVHWGMYSGHG	BAMBI	241	Q13145
WGLKGHLYFLSGNHS	CFAP70	966	Q5T0N1
ESWGHESYRGSHKRK	CLK4	16	Q9HAZ1
WAGGLHHAKKSEASG	HDAC2	136	Q92769
NGGKEKRVAHFGYHW	NDUFA1	31	O15239
HTDWSKYFHGKKVNG	SYN3	101	O14994
YTSKHSWGKTYGEHK	NANS	71	Q9NR45
SWGKTYGEHKRHLEF	NANS	76	Q9NR45
DSWGLSYTGLLHHKG	SPSB3	191	Q6PJ21
SARYGHWHKNKAPGE	STXBP1	516	P61764
GYSSHHGPSWRKKYS	ZC3H3	61	Q8IXZ2
HAKEEKSLHGWGHGS	TIAM2	36	Q8IVF5
WISFGHKFASRIGHG	MTM1	411	Q13496
HFEGSGHGSWGKRNK	RNF10	156	Q8N5U6
GKTYGWSSSLHKHER	ZNF556	376	Q9HAH1
GKGFSHKSSLANHWR	ZNF480	321	Q8WV37
GWSAYLSKHKKIHTG	ZNF732	456	B4DXR9
HGVAWDSKKHTGYVG	USP7	201	Q93009
TTGYGIALHKGSRWK	GRIN2D	786	O15399