Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	UDP-galactosyltransferase activity	B3GALT4 B4GALT3	1.78e-03	32	39	2	GO:0035250
GeneOntologyMolecularFunction	galactosyltransferase activity	B3GALT4 B4GALT3	2.12e-03	35	39	2	GO:0008378
GeneOntologyMolecularFunction	carbohydrate binding	ATRN OS9 MAN2B2 MRC2	3.05e-03	310	39	4	GO:0030246
GeneOntologyMolecularFunction	FAD binding	CRY2 DDO	3.34e-03	44	39	2	GO:0071949
Domain	SH3_9	NOXO1 ARHGEF5 ARHGEF6	6.66e-04	78	41	3	PF14604
Domain	SH3_2	MYO15A ARHGEF5 ARHGEF6	8.85e-04	86	41	3	IPR011511
Domain	SH3_2	MYO15A ARHGEF5 ARHGEF6	8.85e-04	86	41	3	PF07653
Domain	SH3	NOXO1 MYO15A ARHGEF5 ARHGEF6	1.26e-03	216	41	4	PS50002
Domain	SH3	NOXO1 MYO15A ARHGEF5 ARHGEF6	1.26e-03	216	41	4	SM00326
Domain	SH3_domain	NOXO1 MYO15A ARHGEF5 ARHGEF6	1.35e-03	220	41	4	IPR001452
Domain	THIOL_PROTEASE_HIS	TINAGL1 CAPN10	1.59e-03	27	41	2	PS00639
Domain	Pept_cys_AS	TINAGL1 CAPN10	1.71e-03	28	41	2	IPR000169
Domain	EGF	NOTCH2NLA ATRN NOTCH2NLC	2.65e-03	126	41	3	PF00008
Domain	GDS_CDC24_CS	ARHGEF5 ARHGEF6	3.31e-03	39	41	2	IPR001331
Domain	CUB	ATRN SEZ6L2	5.18e-03	49	41	2	PF00431
Domain	CUB	ATRN SEZ6L2	5.39e-03	50	41	2	SM00042
Domain	SH3_1	NOXO1 ARHGEF5 ARHGEF6	5.55e-03	164	41	3	PF00018
Domain	-	ATRN SEZ6L2	5.82e-03	52	41	2	2.60.120.290
Domain	CUB	ATRN SEZ6L2	6.04e-03	53	41	2	PS01180
Domain	CUB_dom	ATRN SEZ6L2	6.95e-03	57	41	2	IPR000859
Domain	DH_1	ARHGEF5 ARHGEF6	8.44e-03	63	41	2	PS00741
Domain	RhoGEF	ARHGEF5 ARHGEF6	9.77e-03	68	41	2	SM00325
Domain	DH_2	ARHGEF5 ARHGEF6	1.03e-02	70	41	2	PS50010
Domain	RhoGEF	ARHGEF5 ARHGEF6	1.03e-02	70	41	2	PF00621
Domain	-	NIBAN3 MTMR10 ARHGEF5 ARHGEF6	1.04e-02	391	41	4	2.30.29.30
Domain	DH-domain	ARHGEF5 ARHGEF6	1.06e-02	71	41	2	IPR000219
Domain	-	ARHGEF5 ARHGEF6	1.06e-02	71	41	2	1.20.900.10
Domain	C_TYPE_LECTIN_1	ATRN MRC2	1.33e-02	80	41	2	PS00615
Domain	PH_dom-like	NIBAN3 MTMR10 ARHGEF5 ARHGEF6	1.39e-02	426	41	4	IPR011993
Domain	Lectin_C	ATRN MRC2	1.46e-02	84	41	2	PF00059
Domain	CLECT	ATRN MRC2	1.46e-02	84	41	2	SM00034
Pubmed	Evolution of Human Brain Size-Associated NOTCH2NL Genes Proceeds toward Reduced Protein Levels.	NOTCH2NLA NOTCH2NLC	9.37e-06	4	44	2	32330268
Pubmed	Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex.	NOTCH2NLA NOTCH2NLC	9.37e-06	4	44	2	29561261
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	ATRN OS9 EIF3A MAN2B2 MRC2 PRSS21 B4GALT3	1.11e-05	613	44	7	22268729
Pubmed	Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.	B3GALT4 MAN2B2 B4GALT3	1.42e-05	37	44	3	2542563
Pubmed	Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.	B3GALT4 MAN2B2 B4GALT3	1.42e-05	37	44	3	2541446
Pubmed	Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.	B3GALT4 MAN2B2 B4GALT3	1.55e-05	38	44	3	2829950
Pubmed	Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.	B3GALT4 MAN2B2 B4GALT3	1.55e-05	38	44	3	2187500
Pubmed	Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis.	NOTCH2NLA NOTCH2NLC	1.56e-05	5	44	2	29856954
Pubmed	Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation.	NOTCH2NLA NOTCH2NLC	1.56e-05	5	44	2	29856955
Pubmed	Disturbance of circadian gene expression in hepatocellular carcinoma.	CRY2 ARHGEF5	1.56e-05	5	44	2	18444243
Pubmed	Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking.	CRY2 BTRC	1.56e-05	5	44	2	26903623
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	EPHX1 ATRN EIF3A MAN2B2 SEZ6L2 MRC2 TMEM132A PRSS21 B4GALT3	1.62e-05	1201	44	9	35696571
Pubmed	Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.	CCDC142 NOTCH2NLA B3GALT4 TINAGL1 MAN2B2 SEZ6L2	1.64e-05	430	44	6	16303743
Pubmed	Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression.	CRY2 BTRC	2.34e-05	6	44	2	17462724
Pubmed	Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein.	B3GALT4 MAN2B2 B4GALT3	2.76e-05	46	44	3	2649653
Pubmed	Comparison of HPLC/ESI-FTICR MS versus MALDI-TOF/TOF MS for glycopeptide analysis of a highly glycosylated HIV envelope glycoprotein.	B3GALT4 B4GALT3	3.27e-05	7	44	2	18565761
Pubmed	Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns.	PRSS33 PRSS21	6.99e-05	10	44	2	14583634
Pubmed	SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.	CRY2 BTRC	1.41e-04	14	44	2	17463251
Pubmed	Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.	B3GALT4 B4GALT3	1.86e-04	16	44	2	10580128
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	TINAGL1 C1QTNF8 TLR9 TMEM204 SEZ6L2 MAMDC4 PRSS21	2.20e-04	985	44	7	12975309
Pubmed	Transcriptional fates of human-specific segmental duplications in brain.	NOTCH2NLA NOTCH2NLC	2.64e-04	19	44	2	30228200
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CRY2 EIF3A MAN2B2 JMJD1C TMEM132A	3.86e-04	493	44	5	15368895
Pubmed	GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.	HCG22 JMJD1C	9.59e-04	36	44	2	23263863
Interaction	DNASE1L1 interactions	ATRN OS9 MAN2B2 TMEM132A B4GALT3	4.35e-06	120	41	5	int:DNASE1L1
Interaction	CBLN4 interactions	OS9 MAN2B2 SEZ6L2 TMEM132A B4GALT3	5.74e-06	127	41	5	int:CBLN4
Cytoband	16p13.3	C1QTNF8 PRSS33 NOXO1 TMEM204 PRSS21	4.18e-06	244	45	5	16p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr16p13	C1QTNF8 PRSS33 NOXO1 TMEM204 PRSS21	6.05e-05	426	45	5	chr16p13
GeneFamily	Proteases, serine	PRSS33 PRSS21	3.14e-03	63	24	2	738
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF5 ARHGEF6	3.44e-03	66	24	2	722
Coexpression	NIKOLSKY_BREAST_CANCER_16P13_AMPLICON	C1QTNF8 PRSS33 NOXO1 TMEM204 PRSS21	1.49e-06	119	43	5	M1788
Coexpression	GSE369_PRE_VS_POST_IL6_INJECTION_SOCS3_KO_LIVER_DN	B3GALT4 EPHX1 ATRN OS9 ARHGEF6	1.87e-05	200	43	5	M5977
Disease	Hepatic fibrosis	TINAGL1 ATRN	1.83e-03	49	38	2	HP_0001395

Protein segments in the cluster

Peptide	Gene	Start	Entry
GGWEDASVGRLQWRR	MAMDC4	501	Q6UXC1
FIGWRTEGRAWRAGR	C22orf39	21	Q6P5X5
WGWGGEDDDIATRVR	B4GALT3	256	O60512
RVEEGGWWEGTLNGR	ARHGEF6	191	Q15052
VWRGRWRGGDVAVKI	ACVR1B	221	P36896
GWLEGVRLSDGERGW	ARHGEF5	1546	Q12774
DSLWRGLAERRGWGQ	BTRC	236	Q9Y297
VSELVLRGGRWGQWE	B3GALT4	186	O96024
LRGGRWGQWERSTEP	B3GALT4	191	O96024
WERSRTGGLRWEVHC	CCDC142	31	Q17RM4
AGEWGTVQLRGSWRV	CAPN10	511	Q9HC96
RELRWWGQSGAGEGR	C17orf113	621	A0A1B0GUU1
RGTELWERDREVWNG	NOTCH2NLA	216	Q7Z3S9
RGAGRARAWAWTELL	NIBAN3	291	Q86XR2
DRGEAWWGAEAARLP	ARL10	41	Q8N8L6
AGWRTAGWEARGRRD	FAM201A	56	Q5SY85
WRFLVGLGDRLGWRD	DNAJC14	346	Q6Y2X3
DWDREIKRTGASGWR	MTMR10	226	Q9NXD2
ILRHRGLADGWRGWT	MYO15A	2251	Q9UKN7
WDWDVTRAGRPGLGA	ATRN	31	O75882
DEARSERWESGRGWR	JMJD1C	21	Q15652
GRGWRSWRAGVIRAV	JMJD1C	31	Q15652
ERKSRWTYRGEWLGG	JPH4	76	Q96JJ6
TSRRWLRGEGWGSPQ	FRYL	1346	O94915
WAEGGRGVSIWDPRR	LCT	401	P09848
RDPRGGQSWRWSDGV	MRC2	751	Q9UBG0
RIVGGRDGRDGEWPW	PRSS33	36	Q8NF86
RGTELWERDREVWNG	NOTCH2NLC	216	P0DPK4
WRDGVRVPGEGASWD	HCG22	36	E2RYF7
GSGGWTLTRRIEDLW	DDO	156	Q99489
DGWWGPGTRSAARED	EPHX1	31	P07099
RGDLWVSWESGVRVF	CRY2	386	Q49AN0
ARPEVAGRRRAWAWG	DNLZ	31	Q5SXM8
KDSRWGDRDSEGTWR	EIF3A	886	Q14152
EGTWRKGPEADSEWR	EIF3A	896	Q14152
GGWRRGPAEESSSWR	EIF3A	1246	Q14152
TGQWRREWDAEKTDG	CCDC9	286	Q9Y3X0
RESWRTAGEGENWRK	C3orf62	131	Q6ZUJ4
RVSDRDLWRGDLWRG	C1QTNF8	41	P60827
RWSWRTGPGRHRGDT	MAN2B2	966	Q9Y2E5
DGAWWFLRRRGVVSD	TINAGL1	276	Q9GZM7
ESRGARGVRVDFWWR	TMEM132A	466	Q24JP5
EWGWRTASHGDLIRG	SEZ6L2	651	Q6UXD5
GARVRVLETSDRGWW	NOXO1	261	Q8NFA2
VRPWAEGTEEGARWL	OS9	596	Q13438
GDRRIRIWGTEGDSW	CIAO1	36	O76071
LAWLPWRGRQSGRDE	TLR9	851	Q9NR96
EDGRRRSVGLWRSCW	TMEM204	36	Q9BSN7
EDAELGRWPWQGSLR	PRSS21	46	Q9Y6M0