Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin conjugating enzyme activity	UBE2L5 UBE2L6 UBE2L3	2.80e-05	37	32	3	GO:0061631
GeneOntologyMolecularFunction	ubiquitin-like protein conjugating enzyme activity	UBE2L5 UBE2L6 UBE2L3	4.42e-05	43	32	3	GO:0061650
Domain	UBQ-conjugating_AS	UBE2L6 UBE2L3	8.32e-04	25	32	2	IPR023313
Domain	UQ_con	UBE2L6 UBE2L3	2.03e-03	39	32	2	PF00179
Domain	UBIQUITIN_CONJUGAT_1	UBE2L6 UBE2L3	2.13e-03	40	32	2	PS00183
Domain	UBIQUITIN_CONJUGAT_2	UBE2L6 UBE2L3	2.24e-03	41	32	2	PS50127
Domain	UBQ-conjugat_E2	UBE2L6 UBE2L3	2.24e-03	41	32	2	IPR000608
Domain	-	UBE2L6 UBE2L3	3.44e-03	51	32	2	3.10.110.10
Domain	UBQ-conjugating_enzyme/RWD	UBE2L6 UBE2L3	3.71e-03	53	32	2	IPR016135
Domain	Prot-tyrosine_phosphatase-like	PTP4A2 MTMR11	1.24e-02	99	32	2	IPR029021
Pubmed	Sequence determinants of E2-E6AP binding affinity and specificity.	UBE2L6 UBE2L3	2.95e-06	3	35	2	17433363
Pubmed	The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis.	UBE2L6 UBE2L3	2.95e-06	3	35	2	16427630
Pubmed	The basis for selective E1-E2 interactions in the ISG15 conjugation system.	UBE2L6 UBE2L3	5.90e-06	4	35	2	18583345
Pubmed	Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1.	UBE2L6 UBE2L3	5.90e-06	4	35	2	11078524
Pubmed	Neddylation positively regulates the ubiquitin E3 ligase activity of parkin.	UBE2L6 UBE2L3	9.82e-06	5	35	2	22271254
Pubmed	Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.	UBE2L6 UBE2L3	9.82e-06	5	35	2	10558980
Pubmed	NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase.	UBE2L6 UBE2L3	9.82e-06	5	35	2	16709802
Pubmed	A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity.	UBE2L6 UBE2L3	1.47e-05	6	35	2	11237715
Pubmed	Identification of molecular determinants required for interaction of ubiquitin-conjugating enzymes and RING finger proteins.	UBE2L6 UBE2L3	1.47e-05	6	35	2	11722579
Pubmed	Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity.	UBE2L6 UBE2L3	2.06e-05	7	35	2	9153201
Pubmed	The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1.	UBE2L6 UBE2L3	2.06e-05	7	35	2	10521492
Pubmed	Autoregulation of Parkin activity through its ubiquitin-like domain.	UBE2L6 UBE2L3	2.06e-05	7	35	2	21694720
Pubmed	Differential regulation of PML-RARα stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1.	UBE2L6 UBE2L3	2.74e-05	8	35	2	22037423
Pubmed	E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis.	UBE2L6 UBE2L3	2.74e-05	8	35	2	24446487
Pubmed	Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO.	UBE2L6 UBE2L3	3.53e-05	9	35	2	12525502
Pubmed	Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.	UBE2L6 UBE2L3	5.38e-05	11	35	2	15107846
Pubmed	Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development.	UBE2L6 UBE2L3	7.62e-05	13	35	2	37205848
Pubmed	Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component, Raptor.	UBE2L6 UBE2L3	8.89e-05	14	35	2	35927303
Pubmed	E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.	UBE2L6 UBE2L3	2.46e-04	23	35	2	19250909
Pubmed	The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.	UBE2L6 UBE2L3	3.15e-04	26	35	2	20061386
Pubmed	Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay.	UBE2L6 UBE2L3	3.40e-04	27	35	2	30097011
Cytoband	22q13.33	ARSA IL17REL	3.90e-04	38	35	2	22q13.33
Cytoband	Ensembl 112 genes in cytogenetic band chr22q13	SH3BP1 ARSA IL17REL	2.03e-03	330	35	3	chr22q13
GeneFamily	Ubiquitin conjugating enzymes E2	UBE2L5 UBE2L6 UBE2L3	1.62e-05	41	22	3	102
Disease	mean platelet volume	ZNF512B ARSA ITGA2B MAST4 CMAHP SEC14L5	9.86e-04	1020	34	6	EFO_0004584
Disease	non-high density lipoprotein cholesterol measurement	BBS1 PGS1 UBE2L5 CMAHP UBE2L3	1.26e-03	713	34	5	EFO_0005689
Disease	HDL cholesterol change measurement, physical activity	PGS1 UBE2L3	2.33e-03	62	34	2	EFO_0003940, EFO_0007805
Disease	very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	PGS1 CMAHP UBE2L3	2.61e-03	239	34	3	EFO_0008317, EFO_0020945
Disease	free cholesterol measurement, high density lipoprotein cholesterol measurement	PGS1 CMAHP UBE2L3	5.65e-03	315	34	3	EFO_0004612, EFO_0008591

Protein segments in the cluster

Peptide	Gene	Start	Entry
NIPPPIISNKNWLRL	CSMD3	311	Q7Z407
ILLQLWLGPQPFPKS	ALG3	416	Q92685
HAAVPNLWDNPPLLL	CT47B1	156	P0C2W7
NLWDNPPLLLLSQRL	CT47B1	161	P0C2W7
SNIAIVLGPNLLWPP	SH3BP1	421	Q9Y3L3
NNLVNSLPLWAPQPP	CD177	111	Q8N6Q3
PEWIQLDQQITPLLL	AIP	221	O00170
QLVNLLPPENLPWCG	PRODH2	56	Q9UF12
ISNVQPLLLLIQWLP	NBEAL1	441	Q6ZS30
PWLLFSLINGLQPVP	SLC24A1	1021	O60721
SLQPQVTWQPPLLLP	IL17REL	321	Q6ZVW7
PLNQLCPWRDSPSLL	MTMR11	571	A4FU01
WLLLAPLLSPAVPQV	PGS1	51	Q32NB8
LLPLQLQGPLNSWIP	ODAM	41	A1E959
PPNNLWIIAAVLAPI	KIAA1549L	1176	Q6ZVL6
LLANLSVEAQPPWLP	ARSA	181	P15289
IVQPDPPIALNWTLL	GHR	146	P10912
RPQQWLQLVLLPPAL	DPP9	371	Q86TI2
LLEPWFLPPSRGLQN	MAST4	1871	O15021
KQNIPLPFLIQDWPL	LINC01554	16	Q52M75
LPQLPPNPLEQDLWN	BBS1	126	Q8NFJ9
QVDLLLQTWQPPALL	SEC14L5	296	O43304
PQLLERWWQPLLDPL	FUZ	261	Q9BT04
LFNEINKIPLPPWAL	SYT2	51	Q8N9I0
WALPGPILQSILPLL	LRRC41	66	Q15345
LLPRGQLEPPLWTQQ	SGSM2	371	O43147
LAPPPTWLLQAAQLR	OCSTAMP	276	Q9BR26
APPAWALNLDPVQLT	ITGA2B	26	P08514
GLLLLELNPPNPWDL	CMAHP	6	Q9Y471
NLLTWQGLIVPDNPP	UBE2L5	31	A0A1B0GUS4
APPPNQIVDDWLNLL	PTP4A2	71	Q12974
NVLVWHALLLPDQPP	UBE2L6	31	O14933
LLLPLPWALQTTNLP	MT-ND3	71	P03897
PLQLQPTPPLQLRWD	nan	256	A8MX80
PLQLQLTPPLQLRWD	nan	226	A8MV72
RPGLPTLNPQLLEAW	ZNF512B	726	Q96KM6
PLQLQPTPPLQLKWD	nan	256	A8MUI8
LSNILLLPWPNLPEN	XPO6	726	Q96QU8
NLLTWQGLIVPDNPP	UBE2L3	31	P68036
RLINLLQEPAPTWTP	GARIN5B	151	Q8N5Q1