Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	intraciliary transport particle A	TTC21B TTC21A	1.04e-04	8	41	2	GO:0030991
MousePheno	abnormal renal glucose reabsorption	PHEX SLC5A1	3.04e-05	4	32	2	MP:0011447
Domain	TPR_8	TTC21B TTC21A	4.94e-03	53	37	2	PF13181
Domain	VWA	COL6A6 ITGAX	5.50e-03	56	37	2	PF00092
Domain	IQ	MYO9B SCN9A	8.71e-03	71	37	2	PF00612
Domain	SH3	MACF1 NEB MPP4	8.87e-03	216	37	3	PS50002
Domain	SH3_domain	MACF1 NEB MPP4	9.33e-03	220	37	3	IPR001452
Domain	-	B4GALNT4 GALNT2	1.12e-02	81	37	2	3.90.550.10
Domain	IQ	MYO9B SCN9A	1.12e-02	81	37	2	SM00015
Domain	VWFA	COL6A6 ITGAX	1.15e-02	82	37	2	PS50234
Domain	VWA	COL6A6 ITGAX	1.20e-02	84	37	2	SM00327
Domain	Nucleotide-diphossugar_trans	B4GALNT4 GALNT2	1.31e-02	88	37	2	IPR029044
Domain	IQ_motif_EF-hand-BS	MYO9B SCN9A	1.37e-02	90	37	2	IPR000048
Pubmed	Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis.	TTC21B TTC21A	1.36e-06	2	41	2	32167205
Pubmed	Genetic Interaction of Thm2 and Thm1 Shapes Postnatal Craniofacial Bone.	TTC21B TTC21A	1.36e-06	2	41	2	35645293
Pubmed	Thm2 interacts with paralog, Thm1, and sensitizes to Hedgehog signaling in postnatal skeletogenesis.	TTC21B TTC21A	4.06e-06	3	41	2	33683377
Pubmed	A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.	NEB SCN9A	1.35e-05	5	41	2	8812438
Pubmed	Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens.	MACF1 OLA1 ITGAX MYO9B	2.47e-05	143	41	4	30397336
Pubmed	HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle.	PSMD7 CCNB3	2.84e-05	7	41	2	9520381
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PHEX MACF1 PSMD7 SNRNP48 CTAGE6 NEB METTL25 HOOK1 SCN9A	3.72e-05	1442	41	9	35575683
Pubmed	Hundreds of variants clustered in genomic loci and biological pathways affect human height.	HDAC11 MYO9B RPL5 PDE11A	8.75e-05	198	41	4	20881960
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	TTC21B XPO4 PSMD7 OLA1 METTL25 HOOK1 TTC21A SIPA1L1	1.32e-04	1321	41	8	27173435
Pubmed	THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia.	TTC21B TTC21A	1.41e-04	15	41	2	18327258
Pubmed	A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.	SUGP1 GALNT2	2.29e-04	19	41	2	19656773
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	XPO4 SLC6A15 SNRNP48 OLA1 GALNT2 HOOK1	2.40e-04	754	41	6	33060197
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	MACF1 DNAH17	2.54e-04	20	41	2	21689717
Pubmed	Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications.	PHEX NEB	5.03e-04	28	41	2	18067320
Pubmed	Biological, clinical and population relevance of 95 loci for blood lipids.	SUGP1 MACF1 GALNT2	6.87e-04	146	41	3	20686565
Cytoband	15q21.3	MYZAP WDR72	4.54e-04	35	41	2	15q21.3
GeneFamily	Intraflagellar transport proteins\|Tetratricopeptide repeat domain containing	TTC21B TTC21A	7.18e-04	24	30	2	615
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC6A15 SLC5A1 SCN9A WDR72	2.28e-05	181	41	4	092a971661b0aa06c1cdf428dbfa7339a26fb678
ToppCell	Mild/Remission-B_intermediate-10\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	MACF1 NEB ITGAX MYO9B	2.38e-05	183	41	4	278064c9f0582463b83bf156d34e77f60187613b
ToppCell	3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NEB DDC PDE11A SCN9A	2.65e-05	188	41	4	1f912ea015f50570e848259d948a0ba682d64bb4
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	USP34 SLC6A15 B4GALNT4 SCN9A	2.65e-05	188	41	4	b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-AT1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	MYZAP PDE11A SCN9A WDR72	3.18e-05	197	41	4	f7ef62d78336812573148f8bfce401877ec4e29c
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PHEX MACF1 COL6A6 RPL5	3.24e-05	198	41	4	0a4b19c3d5e65ecd24fc2ce80ac5276c813282c7
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_neuro-secretory\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DDC PDE11A SCN9A WDR72	3.24e-05	198	41	4	2591e08e3fbee86ac40f11becd8147d6d39fded6
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Transitional_AT2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	MYZAP DDC PDE11A SCN9A	3.31e-05	199	41	4	cd581d7330b471431ef427f8a4f5be553f70e068
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	TIFA MACF1 MYZAP SCN9A	3.37e-05	200	41	4	edb64556b3fefe3144f73b6efe23b9ffd34091d2
Disease	nephronophthisis (implicated_via_orthology)	TTC21B TTC21A	6.09e-05	9	39	2	DOID:12712 (implicated_via_orthology)
Disease	Neuralgia, Supraorbital	GRM5 SCN9A	2.02e-04	16	39	2	C0038870
Disease	Neuralgia, Iliohypogastric Nerve	GRM5 SCN9A	2.02e-04	16	39	2	C0423712
Disease	Neuralgia, Perineal	GRM5 SCN9A	2.02e-04	16	39	2	C0423711
Disease	Neuralgia	GRM5 SCN9A	2.02e-04	16	39	2	C0027796
Disease	Neuralgia, Atypical	GRM5 SCN9A	2.02e-04	16	39	2	C0234247
Disease	Neuralgia, Stump	GRM5 SCN9A	2.02e-04	16	39	2	C0234249
Disease	Paroxysmal Nerve Pain	GRM5 SCN9A	2.02e-04	16	39	2	C0751373
Disease	Nerve Pain	GRM5 SCN9A	2.02e-04	16	39	2	C0751372
Disease	Neuralgia, Ilioinguinal	GRM5 SCN9A	2.02e-04	16	39	2	C0751371
Disease	Neuralgia, Vidian	GRM5 SCN9A	2.02e-04	16	39	2	C0042656
Disease	Major Depressive Disorder	SLC6A15 GRM5 DDC PDE11A	2.94e-04	243	39	4	C1269683
Disease	Unipolar Depression	SLC6A15 GRM5 DDC PDE11A	3.75e-04	259	39	4	C0041696
Disease	sleep duration, high density lipoprotein cholesterol measurement	MACF1 GALNT2 MYZAP	5.52e-04	121	39	3	EFO_0004612, EFO_0005271
Disease	hemoglobin A1 measurement	MACF1 HOOK1 ITGAX MYO9B DDC	5.85e-04	520	39	5	EFO_0007629
Disease	C-reactive protein measurement	USP34 MACF1 SLC6A15 GALNT2 GRM5 DNAH17 WDR72	9.14e-04	1206	39	7	EFO_0004458
Disease	cardioembolic stroke	USP34 HOOK1 GRM5	1.47e-03	170	39	3	EFO_1001976
Disease	triglycerides in large LDL measurement	SUGP1 GALNT2	1.49e-03	43	39	2	EFO_0022319
Disease	response to beta blocker	OLA1 GRM5	1.63e-03	45	39	2	EFO_0007766
Disease	hemolysis	HOOK1 MYO9B	1.77e-03	47	39	2	EFO_0009473
Disease	Male sterility	TDRD7 ENO4	1.85e-03	48	39	2	C0917731
Disease	Male infertility	TDRD7 ENO4	1.85e-03	48	39	2	C0021364

Protein segments in the cluster

Peptide	Gene	Start	Entry
CKAYEYMGYIMEKEQ	TTC21B	1231	Q7Z4L5
IMTEFYQEDEMKLYR	CTAGE6	386	Q86UF2
DFMDDKRVYIMDVYN	HDAC11	191	Q96DB2
KEMVDYMANYMEGIE	DDC	11	P20711
YMKEREEQFILTDYM	CCNB3	1136	Q8WWL7
GFFKRQYKEMMEEAN	ITGAX	1131	P20702
GFIMAEVMKYEDFKE	OLA1	341	Q9NTK5
RQNTYIMDKGFKDYM	MEGF11	911	A6BM72
YEIMNFKEMGKDYFD	GRM5	466	P41594
MNYYEKYKPRMNELE	METTL25	531	Q8N6Q8
FYFEELGKYDMMMDV	GALNT2	316	Q10471
FMELGMVQKFKIDYE	PDE11A	631	Q9HCR9
YYVDMKFKDEDLQEM	MPP4	566	Q96JB8
EMVEEKYQKAENMYA	MACF1	5856	Q9UPN3
YYSVAELKKMMDAFD	KCTD18	201	Q6PI47
LGMYSKEDEYMVFDQ	DNAH17	1631	Q9UFH2
KYVDYMMREFQGKED	EFCAB8	111	A8MWE9
ELMDYNKGKYEVIMG	ENO4	401	A6NNW6
DEDMKAMEERYKMYL	HOOK1	596	Q9UJC3
DYDEYNIMKDFMIGL	COL6A6	821	A6NMZ7
FVYGIDKFMEDLKDM	SLC6A15	546	Q9H2J7
MVRFGEYQFLMEKED	TIFA	116	Q96CG3
DHDYLENMYGMFKKV	PSMD7	71	P51665
YQEEMMNYVGKRKKR	HMGB4	71	Q8WW32
DIFMTEEQKKYYNAM	SCN9A	1471	Q15858
MEYKMNEGVSYEFKF	SIPA1L1	1046	O43166
DYMRYLMEEDEDAYK	RPL5	206	P46777
QELMEDEMKEYYSKN	TDRD7	491	Q8NHU6
GFYKYMKMDKEEGDE	B4GALNT4	401	Q76KP1
DDEYEAFRKRMMLAY	SUGP1	616	Q8IWZ8
VLDKDDMVYMEAYDK	XPO4	391	Q9C0E2
MGYMNERKEPFYKVL	WDR72	326	Q3MJ13
MFVDVYFQEDKKEMM	PHEX	421	P78562
KAYEYMGFIMEKEQS	TTC21A	1236	Q8NDW8
AYMLFYKRMEPEEEN	USP34	2231	Q70CQ2
VGGYDAFMEKYMKAI	SLC5A1	226	P13866
VFDMAYENYMKRKEL	TRMT10C	206	Q7L0Y3
RKMGYTKEEEDEMYN	SNRNP48	81	Q6IEG0
KYQIKDFREKNMDYM	MYO9B	641	Q13459
LEKVRKRMYGDYDEM	MYZAP	111	P0CAP1
AGKIFRAMYDYMAAD	NEB	6611	P20929