Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	KMT2D ERF ETV1 ETV3 SPDEF POU3F1 POU3F2 IRF7 KCNIP3 SP110 ETV3L MEOX1	1.78e-04	1412	51	12	GO:0000981
GeneOntologyBiologicalProcess	positive regulation of podocyte apoptotic process	PLA2R1 PLA2G1B	1.80e-05	3	51	2	GO:1904635
GeneOntologyBiologicalProcess	regulation of podocyte apoptotic process	PLA2R1 PLA2G1B	1.80e-05	3	51	2	GO:1904633
GeneOntologyBiologicalProcess	podocyte apoptotic process	PLA2R1 PLA2G1B	5.97e-05	5	51	2	GO:1903210
GeneOntologyCellularComponent	autophagosome	MYO6 HAP1 OSBPL7 VPS16	1.88e-04	119	50	4	GO:0005776
Domain	ETS_DOMAIN_1	ERF ETV1 ETV3 SPDEF ETV3L	1.16e-08	28	51	5	PS00345
Domain	ETS_DOMAIN_2	ERF ETV1 ETV3 SPDEF ETV3L	1.16e-08	28	51	5	PS00346
Domain	ETS	ERF ETV1 ETV3 SPDEF ETV3L	1.16e-08	28	51	5	SM00413
Domain	Ets_dom	ERF ETV1 ETV3 SPDEF ETV3L	1.16e-08	28	51	5	IPR000418
Domain	ETS_DOMAIN_3	ERF ETV1 ETV3 SPDEF ETV3L	1.16e-08	28	51	5	PS50061
Domain	Ets	ERF ETV1 ETV3 SPDEF ETV3L	1.16e-08	28	51	5	PF00178
Domain	ETV3	ETV3 ETV3L	7.31e-06	2	51	2	IPR032929
Domain	-	ERF ETV1 ETV3 SPDEF IRF7 ETV3L	2.74e-05	218	51	6	1.10.10.10
Domain	TF_POU_3	POU3F1 POU3F2	4.37e-05	4	51	2	IPR016362
Domain	WHTH_DNA-bd_dom	ERF ETV1 ETV3 SPDEF IRF7 ETV3L	4.92e-05	242	51	6	IPR011991
Domain	Dynein_HC_stalk	DNHD1 DNAH5	6.51e-04	14	51	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH5	6.51e-04	14	51	2	IPR013602
Domain	DHC_N2	DNHD1 DNAH5	6.51e-04	14	51	2	PF08393
Domain	MT	DNHD1 DNAH5	6.51e-04	14	51	2	PF12777
Domain	DHC_fam	DNHD1 DNAH5	7.50e-04	15	51	2	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DNAH5	7.50e-04	15	51	2	IPR004273
Domain	Dynein_heavy	DNHD1 DNAH5	7.50e-04	15	51	2	PF03028
Domain	POU	POU3F1 POU3F2	8.56e-04	16	51	2	SM00352
Domain	POU_2	POU3F1 POU3F2	8.56e-04	16	51	2	PS00465
Domain	POU_dom	POU3F1 POU3F2	8.56e-04	16	51	2	IPR000327
Domain	POU_3	POU3F1 POU3F2	8.56e-04	16	51	2	PS51179
Domain	Pou	POU3F1 POU3F2	8.56e-04	16	51	2	PF00157
Domain	POU_1	POU3F1 POU3F2	8.56e-04	16	51	2	PS00035
Domain	POU	POU3F1 POU3F2	9.68e-04	17	51	2	IPR013847
Domain	PP2C	PPM1D PHLPP1	1.21e-03	19	51	2	PF00481
Domain	PRAME_family	PRAMEF5 PRAMEF6	1.21e-03	19	51	2	IPR026271
Domain	PP2Cc	PPM1D PHLPP1	1.35e-03	20	51	2	SM00332
Domain	PPM-type_phosphatase_dom	PPM1D PHLPP1	1.35e-03	20	51	2	IPR001932
Domain	-	PPM1D PHLPP1	1.35e-03	20	51	2	3.60.40.10
Domain	PPM_2	PPM1D PHLPP1	1.35e-03	20	51	2	PS51746
Domain	-	POU3F1 POU3F2	2.46e-03	27	51	2	1.10.260.40
Domain	RICIN	PLA2R1 GALNT16	2.64e-03	28	51	2	SM00458
Domain	RICIN_B_LECTIN	PLA2R1 GALNT16	2.64e-03	28	51	2	PS50231
Domain	Lambda_DNA-bd_dom	POU3F1 POU3F2	2.83e-03	29	51	2	IPR010982
Domain	Ricin_B_lectin	PLA2R1 GALNT16	3.03e-03	30	51	2	IPR000772
Domain	TBC	USP6 SGSM3	7.92e-03	49	51	2	SM00164
Domain	RabGAP-TBC	USP6 SGSM3	9.22e-03	53	51	2	PF00566
Domain	TBC_RABGAP	USP6 SGSM3	9.90e-03	55	51	2	PS50086
Domain	Rab-GTPase-TBC_dom	USP6 SGSM3	9.90e-03	55	51	2	IPR000195
Pubmed	ETS-dependent regulation of a distal Gata4 cardiac enhancer.	ERF ETV1 ETV3 SPDEF	4.26e-08	24	51	4	22056786
Pubmed	ETS-family genes in pancreatic development.	ERF ETV1 ETV3 SPDEF	9.48e-08	29	51	4	17907201
Pubmed	Hippocampus-like corticoneurogenesis induced by two isoforms of the BTB-zinc finger gene Zbtb20 in mice.	ETV1 POU3F1 POU3F2	1.04e-07	7	51	3	17301088
Pubmed	A census of human transcription factors: function, expression and evolution.	KMT2D ERF ETV1 ETV3 SPDEF POU3F1 POU3F2 IRF7 SP110 MEOX1	6.79e-07	908	51	10	19274049
Pubmed	Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex.	ETV1 POU3F1 POU3F2	1.33e-06	15	51	3	18255031
Pubmed	Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals.	PLA2R1 PLA2G1B	2.11e-06	2	51	2	7925459
Pubmed	sPLA2-IB and PLA2R mediate insufficient autophagy and contribute to podocyte injury in idiopathic membranous nephropathy by activation of the p38MAPK/mTOR/ULK1ser757 signaling pathway.	PLA2R1 PLA2G1B	2.11e-06	2	51	2	33184968
Pubmed	sPLA2 IB induces human podocyte apoptosis via the M-type phospholipase A2 receptor.	PLA2R1 PLA2G1B	2.11e-06	2	51	2	25335547
Pubmed	Ets domain transcription factor PE1 suppresses human interstitial collagenase promoter activity by antagonizing protein-DNA interactions at a critical AP1 element.	ERF ETV3	2.11e-06	2	51	2	10913304
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	ERF ETV1 SPDEF POU3F1 POU3F2 MEOX1	2.39e-06	263	51	6	20932939
Pubmed	The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization.	PLA2R1 PLA2G1B	6.32e-06	3	51	2	7721806
Pubmed	Endocytic properties of the M-type 180-kDa receptor for secretory phospholipases A2.	PLA2R1 PLA2G1B	6.32e-06	3	51	2	8550569
Pubmed	Resistance to endotoxic shock in phospholipase A2 receptor-deficient mice.	PLA2R1 PLA2G1B	6.32e-06	3	51	2	9407054
Pubmed	Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg.	ERF ETV1 ETV3	1.06e-05	29	51	3	26097038
Pubmed	Gbx2 directly restricts Otx2 expression to forebrain and midbrain, competing with class III POU factors.	POU3F1 POU3F2	1.26e-05	4	51	2	22566684
Pubmed	A POU factor binding site upstream of the Chx10 homeobox gene is required for Chx10 expression in subsets of retinal progenitor cells and bipolar cells.	POU3F1 POU3F2	1.26e-05	4	51	2	15893976
Pubmed	Structure and evolution of four POU domain genes expressed in mouse brain.	POU3F1 POU3F2	1.26e-05	4	51	2	1565620
Pubmed	Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells.	POU3F1 POU3F2	1.26e-05	4	51	2	26265007
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	ETV1 ETV3 SPDEF POU3F1 POU3F2 IRF7 MEOX1	1.41e-05	544	51	7	28473536
Pubmed	Patterns of neurogenesis and amplitude of Reelin expression are essential for making a mammalian-type cortex.	ETV1 POU3F2	2.10e-05	5	51	2	18197264
Pubmed	The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.	POU3F1 POU3F2	2.10e-05	5	51	2	9105675
Pubmed	Cooperative function of POU proteins and SOX proteins in glial cells.	POU3F1 POU3F2	2.10e-05	5	51	2	9632656
Pubmed	The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development.	POU3F1 POU3F2	2.10e-05	5	51	2	12782656
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DNHD1 KMT2D DDX54 LTF DNAH5	2.41e-05	234	51	5	36243803
Pubmed	Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.	AMOTL1 ETV3 ETV3L	3.04e-05	41	51	3	18951430
Pubmed	Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors.	POU3F1 POU3F2	3.15e-05	6	51	2	18505825
Pubmed	The Pou5f1/Pou3f-dependent but SoxB-independent regulation of conserved enhancer N2 initiates Sox2 expression during epiblast to neural plate stages in vertebrates.	POU3F1 POU3F2	3.15e-05	6	51	2	21185279
Pubmed	Expression of a large family of POU-domain regulatory genes in mammalian brain development.	POU3F1 POU3F2	3.15e-05	6	51	2	2739723
Pubmed	Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS.	ERF ETV3	3.15e-05	6	51	2	17525531
Pubmed	Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development.	KMT2D MEOX1	4.41e-05	7	51	2	16540515
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	KCNJ4 SCN4A KCNQ3 KCNIP3	5.28e-05	139	51	4	16985003
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	PRAMEF5 SP110 PRAMEF6	5.55e-05	50	51	3	31806660
Pubmed	The Transcription Factor Pou3f1 Sheds Light on the Development and Molecular Diversity of Glutamatergic Cerebellar Nuclear Neurons in the Mouse.	POU3F1 POU3F2	5.87e-05	8	51	2	35935334
Pubmed	Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression.	ETV1 POU3F1 KCNIP3	6.61e-05	53	51	3	27210758
Pubmed	Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region.	POU3F1 POU3F2	7.54e-05	9	51	2	15872005
Pubmed	Expression of dopamine pathway genes in the midbrain is independent of known ETS transcription factor activity.	ETV1 SPDEF	1.15e-04	11	51	2	20610757
Pubmed	Murine chromosomal location of four class III POU transcription factors.	POU3F1 POU3F2	1.38e-04	12	51	2	8276397
Pubmed	Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.	HAP1 HEATR3	1.38e-04	12	51	2	22960999
Pubmed	Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2.	POU3F1 POU3F2	1.63e-04	13	51	2	8543156
Pubmed	Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening.	MYO6 IRF7	1.63e-04	13	51	2	12935356
Pubmed	Proneural bHLH and Brn proteins coregulate a neurogenic program through cooperative binding to a conserved DNA motif.	POU3F1 POU3F2	1.90e-04	14	51	2	17141158
Pubmed	Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis.	POU3F1 POU3F2	1.90e-04	14	51	2	15273690
Pubmed	Gde2 regulates cortical neuronal identity by controlling the timing of cortical progenitor differentiation.	ETV1 POU3F2	2.19e-04	15	51	2	22951639
Pubmed	The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex.	POU3F1 POU3F2	2.50e-04	16	51	2	9118797
Pubmed	Replacement of related POU transcription factors leads to severe defects in mouse forebrain development.	POU3F1 POU3F2	2.50e-04	16	51	2	19527706
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF5 PRAMEF6	2.83e-04	17	51	2	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF5 PRAMEF6	2.83e-04	17	51	2	37781892
Pubmed	Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling.	ETV1 POU3F2	2.83e-04	17	51	2	20620871
Pubmed	Loss of miR-17~92 results in dysregulation of Cftr in nephron progenitors.	AMOTL1 MEOX1	2.83e-04	17	51	2	30838872
Pubmed	Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly.	ETV1 POU3F1	3.18e-04	18	51	2	28272472
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF5 PRAMEF6	3.18e-04	18	51	2	29731491
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF5 PRAMEF6	3.18e-04	18	51	2	23894331
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF5 PRAMEF6	3.18e-04	18	51	2	14675769
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF5 PRAMEF6	3.18e-04	18	51	2	12890732
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF5 PRAMEF6	3.18e-04	18	51	2	39181896
Pubmed	PRDM16 regulates a temporal transcriptional program to promote progression of cortical neural progenitors.	POU3F1 POU3F2	3.55e-04	19	51	2	33597191
Pubmed	Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum.	ETV1 POU3F1	3.55e-04	19	51	2	10393115
Pubmed	Sim1-expressing cells illuminate the origin and course of migration of the nucleus of the lateral olfactory tract in the mouse amygdala.	ETV1 POU3F2	3.55e-04	19	51	2	33492553
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF5 PRAMEF6	3.55e-04	19	51	2	28604677
Pubmed	A proteomic survey of microtubule-associated proteins in a R402H TUBA1A mutant mouse.	ETV1 POU3F2	3.55e-04	19	51	2	33137126
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF5 PRAMEF6	3.94e-04	20	51	2	26694250
Pubmed	Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons.	ETV1 POU3F2	3.94e-04	20	51	2	12130536
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF5 PRAMEF6	3.94e-04	20	51	2	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF5 PRAMEF6	3.94e-04	20	51	2	21425410
Pubmed	Meta-analysis identifies four new loci associated with testicular germ cell tumor.	LIPG HEATR3	3.94e-04	20	51	2	23666239
Pubmed	Transcriptional regulation of cortical neuron migration by POU domain factors.	POU3F1 POU3F2	3.94e-04	20	51	2	11859196
Pubmed	Loss of BAF Complex in Developing Cortex Perturbs Radial Neuronal Migration in a WNT Signaling-Dependent Manner.	ETV1 POU3F2	3.94e-04	20	51	2	34220450
Pubmed	Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system.	POU3F1 POU3F2	4.35e-04	21	51	2	28880149
Pubmed	BAC contig from a 3-cM region of mouse chromosome 11 surrounding Brca1.	HAP1 MEOX1	4.35e-04	21	51	2	11013085
Pubmed	A developmental switch in the response of DRG neurons to ETS transcription factor signaling.	ETV1 ETV3	4.35e-04	21	51	2	15836427
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF5 PRAMEF6	4.78e-04	22	51	2	31729367
Pubmed	Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly.	ETV1 POU3F1	4.78e-04	22	51	2	18448648
Pubmed	Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets.	ETV1 POU3F1	5.23e-04	23	51	2	20089898
Pubmed	Bone morphogenetic protein signaling in the developing telencephalon controls formation of the hippocampal dentate gyrus and modifies fear-related behavior.	ETV1 POU3F1	5.23e-04	23	51	2	20445055
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF5 PRAMEF6	5.23e-04	23	51	2	19480014
Pubmed	Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways.	ETV1 POU3F1	5.23e-04	23	51	2	15229646
Pubmed	PRDM16 expression and function in mammalian cochlear development.	MYO6 POU3F2	5.23e-04	23	51	2	35451126
Pubmed	TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction.	HAP1 KCNJ4	5.70e-04	24	51	2	24487590
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	RBM22 ERF ETV1 SPDEF POU3F1 MEOX1	5.80e-04	709	51	6	22988430
Pubmed	Patterning the dorsal telencephalon: a role for sonic hedgehog?	ETV1 POU3F1	6.19e-04	25	51	2	17959802
Pubmed	Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration.	ETV1 POU3F1	6.19e-04	25	51	2	24595293
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF5 PRAMEF6	6.19e-04	25	51	2	37451217
Pubmed	Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.	PRAMEF5 PRAMEF6	6.19e-04	25	51	2	12620990
Pubmed	Patterns of gene expression associated with Pten deficiency in the developing inner ear.	HAP1 LTF	6.19e-04	25	51	2	24893171
Pubmed	Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.	PRAMEF5 PRAMEF6	6.70e-04	26	51	2	18500982
Pubmed	A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis.	ETV1 POU3F2	6.70e-04	26	51	2	26651292
Pubmed	Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.	POU3F1 POU3F2	6.70e-04	26	51	2	22992956
Pubmed	Bhlhb5 regulates the postmitotic acquisition of area identities in layers II-V of the developing neocortex.	ETV1 POU3F2	6.70e-04	26	51	2	18957218
Pubmed	Identification of host proteins required for HIV infection through a functional genomic screen.	USP6 KCNIP3 ZNF831 SP110	6.85e-04	272	51	4	18187620
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	MYO6 WDR6 DDX54 LTF RPL8	7.03e-04	483	51	5	36912080
Pubmed	Chromatin regulation by BAF170 controls cerebral cortical size and thickness.	ETV1 POU3F2	7.78e-04	28	51	2	23643363
Pubmed	The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone.	ETV1 POU3F2	7.78e-04	28	51	2	18794345
Pubmed	Regulation of archicortical arealization by the transcription factor Zbtb20.	ETV1 POU3F1	7.78e-04	28	51	2	22689450
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF5 PRAMEF6	7.78e-04	28	51	2	25089626
Pubmed	Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.	MYO6 MEOX1	8.93e-04	30	51	2	28077597
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF5 PRAMEF6	8.93e-04	30	51	2	38786026
Pubmed	The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex.	ETV1 POU3F1	8.93e-04	30	51	2	19409883
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	HYAL4 MYO6 LIPG RPL8 MEOX1	9.20e-04	513	51	5	25798074
Pubmed	Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.	ETV1 POU3F1 POU3F2	9.32e-04	130	51	3	19386638
Pubmed	Dicer is required for neural stem cell multipotency and lineage progression during cerebral cortex development.	ETV1 POU3F2	9.54e-04	31	51	2	23895693
Cytoband	1p36.21	PRAMEF5 PRAMEF6	2.26e-03	63	51	2	1p36.21
Cytoband	17q21	OSBPL7 MEOX1	2.26e-03	63	51	2	17q21
Cytoband	3p21.31	WDR6 LTF	5.59e-03	100	51	2	3p21.31
Cytoband	Ensembl 112 genes in cytogenetic band chr22q13	KCNJ4 SGSM3 GRAMD4	5.94e-03	330	51	3	chr22q13
GeneFamily	ETS transcription factor family	ERF ETV1 ETV3 SPDEF ETV3L	5.00e-09	28	42	5	534
GeneFamily	Protein phosphatases, Mg2+/Mn2+ dependent	PPM1D PHLPP1	7.01e-04	17	42	2	701
GeneFamily	POU class homeoboxes and pseudogenes	POU3F1 POU3F2	1.29e-03	23	42	2	523
GeneFamily	PRAME family	PRAMEF5 PRAMEF6	1.41e-03	24	42	2	686
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD8-Trm/em_CD8\|GI_small-bowel / Manually curated celltypes from each tissue	RTP5 ETV1 ZNF831 LYST	2.24e-05	144	51	4	a4bb274d553c29c8299354de757ecc5634008c68
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-FB-1\|E18.5-samps / Age Group, Lineage, Cell class and subclass	PNMA2 POU3F1 LTF FREM1	3.30e-05	159	51	4	b4bc888e978b1b577721b891b0af6ba9a1607044
ToppCell	facs-Brain_Myeloid-Hippocampus-24m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPG SPDEF IRF7 SP110	3.99e-05	167	51	4	a21a2b301d0a3d7a41e605f7a3c37548962a331d
ToppCell	facs-Brain_Myeloid-Hippocampus-24m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPG SPDEF IRF7 SP110	3.99e-05	167	51	4	0e746483773bde6582874a33591ab2a578d724eb
ToppCell	facs-Brain_Myeloid-Hippocampus-24m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPG SPDEF IRF7 SP110	3.99e-05	167	51	4	7f3224af9b30082b927a822b91f96e0c88151b4e
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|Myeloid_cells / Location, Cell class and cell subclass	DNHD1 ETV3 KCNQ3 LTF	4.18e-05	169	51	4	dba8f5599aa21feef5b7fdfed2e3ab54748d80f7
ToppCell	facs-Brain_Myeloid-Hippocampus-24m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPG SPDEF IRF7 SP110	4.28e-05	170	51	4	b4f2c05db2c2591561fd42febc72eed3b5e8f9fb
ToppCell	E12.5-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	APOM HAP1 PLA2G1B PROC	4.38e-05	171	51	4	a4d6b0f57eead11b01153688b06b2a45a3b488f2
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LIPG KCNQ3 LTF DNAH5	4.48e-05	172	51	4	0c2d0bb767e5ce089b42ad49e8b303a103de2d5c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LIPG KCNQ3 LTF DNAH5	4.48e-05	172	51	4	eeed177a03c116e9815a8e086d24efc9643b16a4
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	KCNJ4 POU3F1 ZNF831 GALNT16	4.79e-05	175	51	4	21f8f11a8b874d4f7c47931010a2535f2a5a3373
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	KCNJ4 POU3F1 ZNF831 GALNT16	4.79e-05	175	51	4	ff0789f5913c9f3c49159e40b1ec3d2ff175ec9f
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN4A POLD4 FREM1 RPL8	4.90e-05	176	51	4	c6484334187f64cd00cd35e77d8ae436556b4260
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-CD45____B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN4A POLD4 SP110 TMC3	5.12e-05	178	51	4	5a4f97d19265577cfdb3e53f9dc3a9a02cfcffa9
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Macroglial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO6 ETV1 POU3F1 LTF	5.46e-05	181	51	4	04c278ad22e32a4f75af92fc9bfe439363c04f90
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Macroglial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO6 ETV1 POU3F1 LTF	5.46e-05	181	51	4	6d80795f96aac11fec1c946d1f2d16cfe6e38d9a
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HAP1 PNMA2 ETV1 POU3F1	5.95e-05	185	51	4	11c147f3f5570c4761d2bcff3bad28146b4a5861
ToppCell	Hippocampus-Neuronal-Excitatory\|Hippocampus / BrainAtlas - Mouse McCarroll V32	KCNJ4 FBXO27 ZNF831 GALNT16	6.46e-05	189	51	4	4b90d181eb0a42814eeb23bc82e52fd3a12392a7
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM1_(8)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LIPG ETV1 FREM1 RPL8	7.15e-05	194	51	4	fb80a0271ccb1cb3f954ebcf2c5945cb6adb6b8c
ToppCell	356C-Epithelial_cells-Epithelial-B_(AT2)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	MYO6 ETV1 PLA2G1B KCNQ3	7.58e-05	197	51	4	06ed8f293d4ee89f14dc2f43d6cae93bbc02508a
ToppCell	356C-Epithelial_cells-Epithelial-B_(AT2)\|356C / Donor, Lineage, Cell class and subclass (all cells)	MYO6 ETV1 PLA2G1B KCNQ3	7.58e-05	197	51	4	c115d0a45545ed24259ad88872231bf4d4d389d2
Disease	chronic lymphocytic leukemia	HAP1 PHLPP1 SP110 FREM1	3.01e-05	119	44	4	EFO_0000095
Disease	squamous cell carcinoma, esophageal carcinoma	HAP1 HEATR3	9.71e-05	10	44	2	EFO_0000707, EFO_0002916
Disease	Trigonocephaly	ERF FREM1	2.57e-04	16	44	2	C0265535
Disease	Scaphycephaly	ERF FREM1	2.57e-04	16	44	2	C0265534
Disease	Synostotic Posterior Plagiocephaly	ERF FREM1	2.57e-04	16	44	2	C1833340
Disease	Synostotic Anterior Plagiocephaly	ERF FREM1	2.57e-04	16	44	2	C2931150
Disease	Metopic synostosis	ERF FREM1	2.57e-04	16	44	2	C1860819
Disease	Craniosynostosis, Type 1	ERF FREM1	2.57e-04	16	44	2	C4551902
Disease	Acrocephaly	ERF FREM1	2.57e-04	16	44	2	C0030044
Disease	Brachycephaly	ERF FREM1	2.91e-04	17	44	2	C0221356
Disease	Craniosynostosis	ERF FREM1	4.06e-04	20	44	2	C0010278

Protein segments in the cluster

Peptide	Gene	Start	Entry
QCMPLKLRFKRRWSE	ERF	476	P50548
ATIRMKDGLCVPRKW	APOM	86	O95445
EVARLWGRRKCKPQM	ETV3	71	P41162
GWRCCLINRDRKMPT	GRAMD4	466	Q6IC98
MWRAKLRRGTCEPAV	AMOTL1	1	Q8IY63
RLQRWCRAKQMGLEP	POLD4	66	Q9HCU8
RAWTTQLQKLKGRCM	DNHD1	3421	Q96M86
CNPREGKQKWRRKGS	GALNT16	506	Q8N428
RWCPGVRMRFKKTEV	RBM22	56	Q9NW64
NRRMKWKRVKGGQPI	MEOX1	221	P50221
RDGKLCLMWRVGNLR	KCNJ4	196	P48050
GWRGRLKFARKPLCM	KCNQ3	186	O43525
PRSRAAMAQWRKKKG	DDX54	11	Q8TDD1
VARRWGIQKNRPAMN	ETV1	371	P50549
RQGKWQTKDCRRAKP	FREM1	2156	Q5H8C1
WFCNRRQKEKRMTPA	POU3F1	386	Q03052
RKCRDGWRMKNETSP	LIPG	481	Q9Y5X9
LRGPQLWARRMGKCK	IRF7	361	Q92985
QMLWCRLRELKDQGP	PNMA2	306	Q9UL42
MNKSGVNRVVWKRPR	PPM1D	236	O15297
CAKMLVNRALGRWRQ	PPM1D	346	O15297
AKRNCWPRVRGVAMN	RPL8	191	P62917
FPCGRPWKRMEKKRS	PROC	181	P04070
CSRNPTWKPLIRKMN	HEATR3	446	Q7Z4Q2
TWKPLIRKMNTIQCR	HEATR3	451	Q7Z4Q2
RQLRWKMLQKGECPH	HAP1	641	P54257
CRNNGRCIRKMWNAP	HYAL4	381	Q2M3T9
IAWCRKDQQRLKQPM	LYST	3776	Q99698
VARLWGRRKCKPQMN	ETV3L	76	Q6ZN32
RNPCGQEGLRKWMVQ	FBXO27	116	Q8NI29
KWQRPRLSRQALMRC	KCNIP3	31	Q9Y2W7
RKDKMGGKRTVPWNC	CCDC103	61	Q8IW40
NRCRKLPRALKDWQA	DNAH5	1451	Q8TE73
RPKKGKRTSRMWCTQ	OSBPL7	241	Q9BZF2
EMLWRRKKRRPCLEG	INCA1	86	Q0VD86
KMRIWGQRCRLCPAP	RTP5	86	Q14D33
CRPWTMGQKLRALRQ	TMC3	66	Q7Z5M5
LFMGNLRQKCVRWPP	SCN4A	271	P35499
WQRNMRKVRGPPVSC	LTF	41	P02788
PQLWMRLSGALQKKR	SGSM3	121	Q96HU1
PRAVWQFRKMIKCVI	PLA2G1B	21	P04054
AKNWKRNIRCEGMTL	SP110	511	Q9HB58
WFCNRRQKEKRMTPP	POU3F2	401	P20265
VSLRWRCNRKMITGP	PLA2R1	111	Q13018
RRRCEALKLMVQAWP	PRAMEF6	46	Q5VXH4
QVARLWGIRKNRPAM	SPDEF	286	O95238
KQMVWCSRPRSKERA	VPS16	266	Q9H269
RRRCEALKLMVQAWP	PRAMEF5	46	Q5TYX0
LQPVLRQKSCRGMNW	WDR6	601	Q9NNW5
RQKSCRGMNWLAGLR	WDR6	606	Q9NNW5
RKGKMQLPVNRWTRR	PHLPP1	546	O60346
PWRAKMSRGNSKQRK	ZNF831	1271	Q5JPB2
VQQKRLMKTSRCGLW	USP6	306	P35125
RCKQIMKLWRKVPAA	KMT2D	2041	O14686
QKTIRMWLCKRRHKP	MYO6	821	Q9UM54
MWLCKRRHKPRIDGL	MYO6	826	Q9UM54