Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dihydrosphingosine-1-phosphate phosphatase activity	SGPP1 SGPP2	3.53e-06	2	38	2	GO:0070780
GeneOntologyMolecularFunction	sphingosine-1-phosphate phosphatase activity	SGPP1 SGPP2	7.36e-05	7	38	2	GO:0042392
GeneOntologyMolecularFunction	lipid phosphatase activity	SGPP1 SGPP2	5.91e-04	19	38	2	GO:0042577
GeneOntologyMolecularFunction	proteasome binding	USP13 BAG6	6.56e-04	20	38	2	GO:0070628
GeneOntologyBiologicalProcess	maintenance of unfolded protein	USP13 BAG6	9.38e-06	3	37	2	GO:0036506
MousePheno	decreased T-helper 2 cell number	IL25 STAT6	7.50e-05	7	27	2	MP:0008091
MousePheno	small clavicle	TBX15 RUNX2	7.50e-05	7	27	2	MP:0004338
Domain	p53-like_TF_DNA-bd	TBX15 RUNX2 STAT6	1.44e-04	53	36	3	IPR008967
Domain	zf-UBP	USP13 USP51	3.24e-04	14	36	2	PF02148
Domain	ZF_UBP	USP13 USP51	3.24e-04	14	36	2	PS50271
Domain	Znf_UBP	USP13 USP51	3.24e-04	14	36	2	IPR001607
Domain	-	SGPP1 SGPP2	5.42e-04	18	36	2	1.20.144.10
Domain	acidPPc	SGPP1 SGPP2	5.42e-04	18	36	2	SM00014
Domain	P_Acid_Pase_2/haloperoxidase	SGPP1 SGPP2	6.72e-04	20	36	2	IPR000326
Domain	PAP2	SGPP1 SGPP2	6.72e-04	20	36	2	PF01569
Domain	VWC	MUC5AC PXDNL	1.32e-03	28	36	2	PF00093
Domain	VWFC_1	MUC5AC PXDNL	2.18e-03	36	36	2	PS01208
Domain	VWC	MUC5AC PXDNL	2.43e-03	38	36	2	SM00214
Domain	VWFC_2	MUC5AC PXDNL	2.43e-03	38	36	2	PS50184
Domain	VWF_dom	MUC5AC PXDNL	2.96e-03	42	36	2	IPR001007
Domain	USP_CS	USP13 USP51	7.17e-03	66	36	2	IPR018200
Domain	USP_1	USP13 USP51	8.03e-03	70	36	2	PS00972
Domain	UCH	USP13 USP51	8.26e-03	71	36	2	PF00443
Domain	USP_2	USP13 USP51	8.26e-03	71	36	2	PS00973
Domain	USP_3	USP13 USP51	8.48e-03	72	36	2	PS50235
Domain	USP_dom	USP13 USP51	8.48e-03	72	36	2	IPR028889
Domain	Peptidase_C19_UCH	USP13 USP51	8.48e-03	72	36	2	IPR001394
Domain	Cys-rich_flank_reg_C	SLITRK6 PXDNL	1.30e-02	90	36	2	IPR000483
Domain	LRRCT	SLITRK6 PXDNL	1.30e-02	90	36	2	SM00082
Pathway	WP_BIOSYNTHESIS_AND_TURNOVER_OF_1DEOXYSPHINGOID_BASES	SGPP1 SGPP2	8.40e-05	8	25	2	M45534
Pathway	REACTOME_SPHINGOLIPID_CATABOLISM	SGPP1 SGPP2	1.97e-04	12	25	2	M48264
Pathway	REACTOME_SPHINGOLIPID_CATABOLISM	SGPP1 SGPP2	1.97e-04	12	25	2	MM17238
Pathway	WP_METABOLISM_OF_SPHINGOLIPIDS_IN_ER_AND_GOLGI_APPARATUS	SGPP1 SGPP2	6.21e-04	21	25	2	M39459
Pathway	WP_SPHINGOLIPID_METABOLISM_OVERVIEW	SGPP1 SGPP2	8.83e-04	25	25	2	MM15931
Pathway	WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY	SGPP1 SGPP2	9.56e-04	26	25	2	M39784
Pathway	WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY	SGPP1 SGPP2	9.56e-04	26	25	2	MM15892
Pathway	WP_SPHINGOLIPID_METABOLISM_OVERVIEW	SGPP1 SGPP2	1.03e-03	27	25	2	M39863
Pathway	WP_IL19_SIGNALING	MUC5AC STAT6	1.11e-03	28	25	2	M48111
Pathway	KEGG_SPHINGOLIPID_METABOLISM	SGPP1 SGPP2	2.15e-03	39	25	2	M15955
Pubmed	Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2.	SGPP1 SGPP2	1.16e-06	2	38	2	12411432
Pubmed	Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation.	SGPP1 SGPP2	1.16e-06	2	38	2	27059959
Pubmed	Critical role of IL-25 in nematode infection-induced alterations in intestinal function.	IL25 STAT6	3.48e-06	3	38	2	20974983
Pubmed	Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma.	IL25 STAT6	3.48e-06	3	38	2	19329997
Pubmed	IL-25 or IL-17E Protects against High-Fat Diet-Induced Hepatic Steatosis in Mice Dependent upon IL-13 Activation of STAT6.	IL25 STAT6	3.48e-06	3	38	2	26423151
Pubmed	The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation.	IL25 STAT6	6.96e-06	4	38	2	30291131
Pubmed	Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine.	IL25 STAT6	6.96e-06	4	38	2	18762568
Pubmed	Interleukin-13 induces mucin 5AC production involving STAT6/SPDEF in human airway epithelial cells.	MUC5AC STAT6	6.96e-06	4	38	2	21275604
Pubmed	A SPRY1 domain cardiac ryanodine receptor variant associated with short-coupled torsade de pointes.	GJA5 TNNI3K	6.96e-06	4	38	2	33664309
Pubmed	Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes.	DYRK1A RUNX2	1.16e-05	5	38	2	37102702
Pubmed	The Chaperone BAG6 Regulates Cellular Homeostasis between Autophagy and Apoptosis by Holding LC3B.	USP13 BAG6	1.16e-05	5	38	2	33241194
Pubmed	Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin.	USP13 BAG6	2.43e-05	7	38	2	38043062
Pubmed	Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivity.	IL25 STAT6	2.43e-05	7	38	2	17177681
Pubmed	QTL mapping in a mouse model of cardiomyopathy reveals an ancestral modifier allele affecting heart function and survival.	TNNI3K LHX8	2.43e-05	7	38	2	16075368
Pubmed	Expression of forkhead box transcription factor genes Foxp1 and Foxp2 during jaw development.	RUNX2 LHX8	3.24e-05	8	38	2	26969076
Pubmed	Mesenchymal signaling in dorsoventral differentiation of palatal epithelium.	RUNX2 LHX8	4.16e-05	9	38	2	26123167
Pubmed	Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A).	DYRK1A SYN1	4.16e-05	9	38	2	24327345
Pubmed	SALL1 truncated protein expression in Townes-Brocks syndrome leads to ectopic expression of downstream genes.	GJA5 RUNX2	4.16e-05	9	38	2	18470945
Pubmed	Common variants at 5q22 associate with pediatric eosinophilic esophagitis.	SHROOM3 STAT6	4.16e-05	9	38	2	20208534
Pubmed	USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.	USP13 BAG6	6.35e-05	11	38	2	24424410
Pubmed	Dynamic regulation of sphingosine-1-phosphate homeostasis during development of mouse metanephric kidney.	SGPP1 SGPP2	6.35e-05	11	38	2	19073640
Pubmed	Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis.	TRPA1 STAT6	7.62e-05	12	38	2	33220232
Pubmed	Notch signaling promotes airway mucous metaplasia and inhibits alveolar development.	MUC5AC STAT6	7.62e-05	12	38	2	19369400
Pubmed	USP51 promotes deubiquitination and stabilization of ZEB1.	USP13 USP51	9.00e-05	13	38	2	29119051
Pubmed	A type 2 immune circuit in the stomach controls mammalian adaptation to dietary chitin.	IL25 STAT6	9.00e-05	13	38	2	37676935
Pubmed	Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo.	RUNX2 LHX8	1.05e-04	14	38	2	19414008
Pubmed	Innate type 2 immunity controls hair follicle commensalism by Demodex mites.	IL25 STAT6	1.05e-04	14	38	2	36044899
Pubmed	Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.	IL25 STAT6	1.05e-04	14	38	2	24631157
Pubmed	Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis.	TBX15 RUNX2	1.38e-04	16	38	2	33482080
Pubmed	The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells.	IL25 STAT6	2.18e-04	20	38	2	21460847
Pubmed	Hedgehog signaling patterns the oral-aboral axis of the mandibular arch.	RUNX2 LHX8	2.65e-04	22	38	2	30638444
Pubmed	Genome-wide Identification of Foxf2 Target Genes in Palate Development.	TBX15 RUNX2	2.90e-04	23	38	2	32040930
Pubmed	Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network.	MED14 GJA5	3.72e-04	26	38	2	34506481
Pubmed	ISLET1-Dependent β-Catenin/Hedgehog Signaling Is Required for Outgrowth of the Lower Jaw.	RUNX2 LHX8	6.76e-04	35	38	2	28069742
Pubmed	Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development.	SGPP1 SGPP2	8.83e-04	40	38	2	21319224
Pubmed	Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.	MUC5AC STAT6	9.28e-04	41	38	2	22675208
Cytoband	2q36.1	WDFY1 SGPP2	1.13e-04	19	38	2	2q36.1
Cytoband	1p31.1	TNNI3K LHX8	1.60e-03	71	38	2	1p31.1
Cytoband	Ensembl 112 genes in cytogenetic band chr2q36	WDFY1 SGPP2	2.28e-03	85	38	2	chr2q36
Cytoband	Ensembl 112 genes in cytogenetic band chrXp11	MED14 SYN1 USP51	3.75e-03	377	38	3	chrXp11
Cytoband	11q12.1	OR5G3 OR4D9	7.91e-03	161	38	2	11q12.1
GeneFamily	Sphingosine-1-phosphate phosphatases	SGPP1 SGPP2	2.31e-06	2	28	2	1070
GeneFamily	Ubiquitin specific peptidases	USP13 USP51	3.38e-03	56	28	2	366
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_top-relative-expression-ranked_200	TBX15 SLITRK6 RUNX2 LHX8 KLHL28	6.04e-06	175	32	5	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_200
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000	MED14 PAPPA2 SYN1 TMTC2 SHROOM3 RUNX2 GARNL3 USP51 CELF3	1.03e-05	986	32	9	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_top-relative-expression-ranked_100	TBX15 SLITRK6 RUNX2 LHX8	1.08e-05	92	32	4	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_100
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_500	SYN1 TMTC2 SHROOM3 GARNL3 USP51 CELF3	8.52e-05	496	32	6	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_top-relative-expression-ranked_200	TBX15 SLITRK6 RUNX2 LHX8	1.17e-04	169	32	4	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_200
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_top-relative-expression-ranked_100	SLITRK6 RUNX2 LHX8	2.19e-04	78	32	3	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_100
Disease	facial morphology measurement	TBX15 RUNX2 LHX8 PXDNL SGPP2	1.58e-04	466	33	5	EFO_0007841
Disease	gastric ulcer (biomarker_via_orthology)	IL25 MUC5AC	2.51e-04	21	33	2	DOID:10808 (biomarker_via_orthology)
Disease	asthma (implicated_via_orthology)	TRPA1 STAT6	7.05e-04	35	33	2	DOID:2841 (implicated_via_orthology)
Disease	asthma (biomarker_via_orthology)	MUC5AC STAT6	1.99e-03	59	33	2	DOID:2841 (biomarker_via_orthology)
Disease	obstructive sleep apnea	TBX15 LHX8	2.49e-03	66	33	2	EFO_0003918
Disease	descending aortic diameter	PAPPA2 STAT6	4.37e-03	88	33	2	EFO_0021788
Disease	Inhalant adrenergic use measurement	MUC5AC STAT6	5.18e-03	96	33	2	EFO_0009941
Disease	gallstones	SHROOM3 MUC5AC	6.51e-03	108	33	2	EFO_0004210

Protein segments in the cluster

Peptide	Gene	Start	Entry
AHSAYLSPMATMAAV	CELF3	221	Q5SZQ8
SPNSRFTYHMVSGMS	ERVK-18	76	O42043
HVVRPMSHYTTPMVL	BAG6	356	P46379
TGPAHYMTEGHLTMR	DYRK1A	726	Q13627
AIGHTMYTMHLPFCV	OR2AG2	156	A6NM03
MDVYMSHAPTGSSVH	LIPN	276	Q5VXI9
MPTDMEHTGHYLHLA	EVI2A	1	P22794
HAEYASGLMSPLTMS	KIF24	1041	Q5T7B8
TMLTALHSYMDAHSP	LHX8	321	Q68G74
MTTCPKSMTYHYHVS	MUC5AC	701	P98088
VFTVTMDAHLHSPMY	OR4F15	46	Q8NGB8
TSYHSTVNQSPSMMH	MED14	1026	O60244
MVTVTCESHLHTPMY	OR4D9	46	Q8NGE8
YYGMPGHTDTMIHEV	PAPPA2	721	Q9BXP8
AAVTPDHSYTRMLMH	PXDNL	791	A1KZ92
MDHTSPTYMLANLTH	KLHL28	1	Q9NXS3
STPSLVYMGHAMHTV	GJA5	86	P36382
SPNSRFTYHMVSGMS	ERVK-5	76	Q9HDB8
VAFLAMVMGTHTYSH	IL25	21	Q9H293
GHEIMFHVSTMLPYS	GARNL3	271	Q5VVW2
VGPYAMALISTMTHT	OR5G3	146	P0C626
SGMSLGMSATTHYHT	RUNX2	406	Q13950
STTYPVVVKMGHAHS	SYN1	261	P17600
HMVSPMVHVYRSPSF	SLITRK6	681	Q9H5Y7
QYLPSGMEHSMHMIS	TBX15	556	Q96SF7
EYSMPSTHAMSGTAI	SGPP1	201	Q9BX95
YTPAMMHRSNGHTLT	SHROOM3	1381	Q8TF72
LIAEYGMPSTHAMAA	SGPP2	156	Q8IWX5
MSSLFHAMYSGSRTP	USP51	411	Q70EK9
TALHHASMGGYTQTM	TRPA1	516	O75762
PSHYGQSGISMSHMD	STAT6	826	P42226
TFMAGLMFASHPIHT	TMTC2	116	Q8N394
GDMSYSIRHSISMPA	TPD52L1	126	Q16890
FSHMGASMHLRTPFT	TM6SF2	311	Q9BZW4
AGITMSHTTTPMVTY	ZC3H10	406	Q96K80
GYVSDPMSSMHFHSC	TNNI3K	811	Q59H18
PSIYHTMASPCSAMA	WDFY1	61	Q8IWB7
TMASPCSAMAYHHDS	WDFY1	66	Q8IWB7
FISHMGTSTMSGHYI	USP13	811	Q92995