Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	E1_4HB	UBA1 UBA7	1.10e-04	3	114	2	PF16191
Domain	E1_FCCH	UBA1 UBA7	1.10e-04	3	114	2	PF16190
Domain	UBQ-activ_enz_E1	UBA1 UBA7	1.10e-04	3	114	2	IPR018075
Domain	UBA_e1_C	UBA1 UBA7	1.10e-04	3	114	2	SM00985
Domain	Ub-activating_enz_E1_C	UBA1 UBA7	1.10e-04	3	114	2	IPR018965
Domain	E1_4HB	UBA1 UBA7	1.10e-04	3	114	2	IPR032420
Domain	E1_FCCH	UBA1 UBA7	1.10e-04	3	114	2	IPR032418
Domain	E1_UFD	UBA1 UBA7	1.10e-04	3	114	2	PF09358
Domain	UBQ-activ_enz_E1_CS	UBA1 UBA7	2.20e-04	4	114	2	IPR018074
Domain	Synaptogyrin	SYNGR3 SYNGR1	2.20e-04	4	114	2	IPR016579
Domain	-	UBA1 UBA7	2.20e-04	4	114	2	1.10.3240.10
Domain	UBQ-activ_enz_E1_Cys_AS	UBA1 UBA7	2.20e-04	4	114	2	IPR033127
Domain	UBIQUITIN_ACTIVAT_1	UBA1 UBA7	3.65e-04	5	114	2	PS00536
Domain	UBA_E1_Cys	UBA1 UBA7	3.65e-04	5	114	2	IPR019572
Domain	UBIQUITIN_ACTIVAT_2	UBA1 UBA7	3.65e-04	5	114	2	PS00865
Domain	UBA_e1_thiolCys	UBA1 UBA7	3.65e-04	5	114	2	PF10585
Domain	AGC-kinase_C	SGK3 GRK2 GRK3 PKN1	3.79e-04	56	114	4	IPR000961
Domain	AGC_KINASE_CTER	SGK3 GRK2 GRK3 PKN1	3.79e-04	56	114	4	PS51285
Domain	S_TK_X	SGK3 GRK2 GRK3 PKN1	3.79e-04	56	114	4	SM00133
Domain	UBQ/SUMO-activ_enz_E1-like	UBA1 UBA7	5.45e-04	6	114	2	IPR000011
Domain	Synaptobrevin/VAMP	VAMP3 VAMP1	5.45e-04	6	114	2	IPR016444
Domain	GPCR_kinase	GRK2 GRK3	7.60e-04	7	114	2	IPR000239
Domain	SYNAPTOBREVIN	VAMP3 VAMP1	1.01e-03	8	114	2	PS00417
Domain	-	VAMP3 VAMP1	1.01e-03	8	114	2	1.10.3840.10
Domain	RGS	RGS22 GRK2 GRK3	1.26e-03	35	114	3	PF00615
Domain	RGS	RGS22 GRK2 GRK3	1.26e-03	35	114	3	SM00315
Domain	RGS	RGS22 GRK2 GRK3	1.37e-03	36	114	3	PS50132
Domain	ThiF_NAD_FAD-bd	UBA1 UBA7	1.61e-03	10	114	2	IPR000594
Domain	ThiF	UBA1 UBA7	1.61e-03	10	114	2	PF00899
Domain	RGS	RGS22 GRK2 GRK3	1.72e-03	39	114	3	IPR016137
Domain	Synaptobrevin	VAMP3 VAMP1	1.96e-03	11	114	2	PF00957
Domain	V_SNARE	VAMP3 VAMP1	2.34e-03	12	114	2	PS50892
Domain	Synaptobrevin	VAMP3 VAMP1	2.76e-03	13	114	2	IPR001388
Domain	Galactosyl_T	B3GALT4 B3GNT3	4.19e-03	16	114	2	PF01762
Domain	Glyco_trans_31	B3GALT4 B3GNT3	4.19e-03	16	114	2	IPR002659
Domain	Kinase-like_dom	GAK CAMKK1 TRRAP SGK3 GRK2 GRK3 MARK4 PKN1 DNM1	5.98e-03	542	114	9	IPR011009
Pathway	REACTOME_CLATHRIN_MEDIATED_ENDOCYTOSIS	HIP1 GAK NECAP1 VAMP3 GRK2 GRK3 AGFG1 DNM1	3.65e-06	142	91	8	MM15499
Pathway	REACTOME_CLATHRIN_MEDIATED_ENDOCYTOSIS	HIP1 GAK NECAP1 VAMP3 GRK2 GRK3 AGFG1 DNM1	4.27e-06	145	91	8	M27753
Pathway	BIOCARTA_PITX2_PATHWAY	MED1 TRRAP LDB1	1.12e-04	15	91	3	MM1439
Pathway	BIOCARTA_PITX2_PATHWAY	MED1 TRRAP LDB1	1.37e-04	16	91	3	M8516
Pathway	PID_THROMBIN_PAR1_PATHWAY	GRK3 PKN1 DNM1 VASP	1.65e-04	43	91	4	M238
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	EHBP1 TRPM4 ABAT HIVEP2 MCM8 MID2 CCDC32 SPTB CEP192 PATL1 KCNIP3 TRRAP ITFG1 CEP170 PPP4C GRK3 LDB1 PKN1 RBFOX2	4.95e-07	1489	116	19	28611215
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	GAK CAMKK1 CEP192 TRRAP EML3 CYFIP2 FAM83H SGK3 CEP170 DEFA6 PKN1 DDX60L RBFOX2 PPP6R3	2.19e-06	910	116	14	36736316
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	INTS7 PATL1 TRRAP DDB1 GGT7 CEP170 LSM14B SNRPA1 SNRPB2	3.89e-06	364	116	9	24778252
Pubmed	Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells.	ESR1 MED1 TRRAP	4.26e-06	10	116	3	12738788
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	STRN3 MED1 LZIC DDB1 NECAP1 CEP170 TRMT1L LSM14B VASP PPP6R3	4.36e-06	472	116	10	38943005
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	SF3B4 MID2 PATL1 MED1 CYFIP2 NECAP1 CEP170 UBA1 GRK2 AGFG1 UQCRC2 LSM14B	5.78e-06	724	116	12	36232890
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	EHBP1 SF3B4 HIVEP2 CAMKK1 CEP192 RAB11FIP1 FAM83H CEP170 VPS13D IPO9 MARK4 AGFG1 CSPP1	6.32e-06	861	116	13	36931259
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	GAK SF3B4 ABCB7 DDB1 CYFIP2 VAMP3 THAP11 UBA7 PPP4C SLC25A15 CSPG4 FUNDC2 UQCRC2 SNRPA1 CFAP44 SNRPB2 ATP5F1A	6.57e-06	1451	116	17	30550785
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	STRN3 SF3B4 ACAT2 DDB1 CYFIP2 GSS CEP170 UBA1 IPO9 AGFG1 TRMT1L LSM14B SNRPA1 ATP5F1A TPD52	6.79e-06	1149	116	15	35446349
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	EHBP1 HS1BP3 PATL1 ANO10 RAB11FIP1 NECAP1 FAM83H VAMP3 GRK2 SYNGR3 AGFG1 LSM14B SNRPB2 RBFOX2	6.96e-06	1007	116	14	34597346
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	EHBP1 STRN3 MCM8 PATL1 RAB11FIP1 CEP170 PPP4C PWP2 AGFG1 LSM14B SNRPA1 SNRPB2 VASP PPP6R3	9.79e-06	1038	116	14	26673895
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	SF3B4 CEP192 RAB11FIP1 CYFIP2 VAMP3 UBA1 IPO9 PPP4C ROBO1 UQCRC2 CSPP1 ATP5F1A TPD52 PPP6R3	1.10e-05	1049	116	14	27880917
Pubmed	Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA.	SNRPA1 SNRPB2	1.10e-05	2	116	2	9716128
Pubmed	The ERα-NRF2 signalling axis promotes bicalutamide resistance in prostate cancer.	ESR1 NFE2L2	1.10e-05	2	116	2	36376959
Pubmed	Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins.	ESR1 MED1	1.10e-05	2	116	2	15471764
Pubmed	Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.	GRK2 GRK3	1.10e-05	2	116	2	10198406
Pubmed	Interaction of ERα and NRF2 Impacts Survival in Ovarian Cancer Patients.	ESR1 NFE2L2	1.10e-05	2	116	2	30597961
Pubmed	G-protein coupled receptor kinase 2 and 3 expression in human detrusor cultured smooth muscle cells.	GRK2 GRK3	1.10e-05	2	116	2	11762794
Pubmed	Reaffirmation of GAK, but not HLA-DRA, as a Parkinson's disease susceptibility gene in a Taiwanese population.	GAK HLA-DRA	1.10e-05	2	116	2	24039160
Pubmed	Cloning of GRK2 cDNA from S49 murine lymphoma cells.	GRK2 GRK3	1.10e-05	2	116	2	8638670
Pubmed	Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.	GRK2 GRK3	1.10e-05	2	116	2	33060647
Pubmed	Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation.	ESR1 MED1	1.10e-05	2	116	2	20351249
Pubmed	G protein--coupled receptor kinases.	GRK2 GRK3	1.10e-05	2	116	2	8035170
Pubmed	SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells.	ESR1 SGK3	1.10e-05	2	116	2	21084382
Pubmed	Roles of Estrogen Receptor-α and the Coactivator MED1 During Human Endometrial Decidualization.	ESR1 MED1	1.10e-05	2	116	2	26849466
Pubmed	BRCA2 represses the transcriptional activity of pS2 by E2-ERα.	ESR1 BRCA2	1.10e-05	2	116	2	34952473
Pubmed	Stabilization of estrogen receptor α by USP37 contributes to the progression of breast cancer.	ESR1 USP37	1.10e-05	2	116	2	36221793
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	ABCB7 DDB1 THAP11 CEP170 IPO9 PWP2 UQCRC2 ATP5F1A RBFOX2 PPP6R3	1.92e-05	560	116	10	35241646
Pubmed	Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton.	CYFIP2 DNM1 VASP	2.38e-05	17	116	3	14506234
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	CAMKK1 USP37 EML3 CYFIP2 CEP170 ATP5F1A PPP6R3	2.48e-05	255	116	7	15324660
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	STRN3 ABCB7 CEP192 PATL1 DDB1 FAM83H ALDH1A2 GRK2 BRCA2 SLC25A15 RBFOX2 PPP6R3	2.93e-05	853	116	12	28718761
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	EHBP1 TRPM4 SF3B4 CEP192 RAB11FIP1 TRRAP FAM83H ITFG1 AGFG1 ROBO1 TPD52	3.01e-05	719	116	11	35337019
Pubmed	Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309.	GRK2 GRK3	3.30e-05	3	116	2	10754297
Pubmed	HIV-1 infection increases microRNAs that inhibit Dicer1, HRB and HIV-EP2, thereby reducing viral replication.	HIVEP2 AGFG1	3.30e-05	3	116	2	30682089
Pubmed	Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.	KCNIP3 RYR2	3.30e-05	3	116	2	29730765
Pubmed	Cofactors of LIM Domains Associate with Estrogen Receptor α to Regulate the Expression of Noncoding RNA H19 and Corneal Epithelial Progenitor Cell Function.	ESR1 LDB1	3.30e-05	3	116	2	27129775
Pubmed	HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1.	ESR1 MED1	3.30e-05	3	116	2	29187405
Pubmed	The aryl hydrocarbon receptor and estrogen receptor alpha differentially modulate nuclear factor erythroid-2-related factor 2 transactivation in MCF-7 breast cancer cells.	ESR1 NFE2L2	3.30e-05	3	116	2	23583297
Pubmed	Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs.	CDH23 DCHS1	3.30e-05	3	116	2	11597768
Pubmed	Mutational analysis of the estrogen receptor-alpha gene in familial ovarian cancer.	ESR1 BRCA2	3.30e-05	3	116	2	16176503
Pubmed	SGK3 sustains ERα signaling and drives acquired aromatase inhibitor resistance through maintaining endoplasmic reticulum homeostasis.	ESR1 SGK3	3.30e-05	3	116	2	28174265
Pubmed	Keap1-Nrf2 Interaction Suppresses Cell Motility in Lung Adenocarcinomas by Targeting the S100P Protein.	S100P NFE2L2	3.30e-05	3	116	2	26078391
Pubmed	Characterization of synaptogyrin 3 as a new synaptic vesicle protein.	SYNGR3 SYNGR1	3.30e-05	3	116	2	14755516
Pubmed	Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.	GRK2 GRK3	3.30e-05	3	116	2	10085131
Pubmed	Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.	GRK2 GRK3	3.30e-05	3	116	2	7761854
Pubmed	The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors.	GRK2 GRK3	3.30e-05	3	116	2	31604529
Pubmed	Binding affinity and cooperativity control U2B″/snRNA/U2A' RNP formation.	SNRPA1 SNRPB2	3.30e-05	3	116	2	24866816
Pubmed	Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk.	GRK2 GRK3	3.30e-05	3	116	2	12130708
Pubmed	A negative coregulator for the human ER.	ESR1 RBFOX2	3.30e-05	3	116	2	11875103
Pubmed	Oncotype Dx recurrence score among BRCA1/2 germline mutation carriers with hormone receptors positive breast cancer.	ESR1 BRCA2	3.30e-05	3	116	2	28120435
Pubmed	Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.	ESR1 MED1 DDB1	3.37e-05	19	116	3	17392787
Pubmed	Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.	IPO9 BRCA2 SLC25A15 UQCRC2 RBFOX2	3.66e-05	111	116	5	32683582
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TRPM4 STRN3 HIP1 INTS7 ESR1 MED1 RAB11FIP1 TRRAP CYFIP2 CELSR1 PWP2 UQCRC2 TRMT1L LSM14B ATP5F1A PPP6R3	3.84e-05	1497	116	16	31527615
Pubmed	Molecular architecture of the human 17S U2 snRNP.	SF3B4 SNRPA1 SNRPB2	4.60e-05	21	116	3	32494006
Pubmed	Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.	SF3B4 SNRPA1 SNRPB2	4.60e-05	21	116	3	36797247
Pubmed	The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.	MED1 DDB1 ADCY5 THAP11 IPO9 DNM1	5.73e-05	199	116	6	36688959
Pubmed	Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization.	ABAT SPTB ADCY5 CYFIP2 UBA1 UQCRC2 DNM1 ATP5F1A	6.48e-05	403	116	8	30562941
Pubmed	Phenotypic analysis of familial breast cancer: comparison of BRCAx tumors with BRCA1-, BRCA2-carriers and non-familial breast cancer.	ESR1 BRCA2	6.59e-05	4	116	2	25736863
Pubmed	The glucose transporter (GLUT-4) and vesicle-associated membrane protein-2 (VAMP-2) are segregated from recycling endosomes in insulin-sensitive cells.	VAMP3 VAMP1	6.59e-05	4	116	2	8707843
Pubmed	Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.	GRK2 GRK3	6.59e-05	4	116	2	8917529
Pubmed	Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice.	ZIC2 CELSR1	6.59e-05	4	116	2	29463853
Pubmed	Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus.	GRK2 GRK3	6.59e-05	4	116	2	23734232
Pubmed	Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription.	ESR1 MED1	6.59e-05	4	116	2	10760302
Pubmed	Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer.	ESR1 LDB1	6.59e-05	4	116	2	19117995
Pubmed	Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder.	GRK2 GRK3	6.59e-05	4	116	2	21784156
Pubmed	Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C.	GRK2 GRK3	6.59e-05	4	116	2	8662816
Pubmed	Functional interactions between the estrogen receptor and DRIP205, a subunit of the heteromeric DRIP coactivator complex.	ESR1 MED1	6.59e-05	4	116	2	10770935
Pubmed	Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31.	VAMP3 VAMP1	6.59e-05	4	116	2	9396746
Pubmed	Structural and functional modularity of the U2 snRNP in pre-mRNA splicing.	SF3B4 SNRPA1 SNRPB2	6.95e-05	24	116	3	31744343
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	EHBP1 STRN3 GAK MED1 LZIC DDB1 CEP170 UBA1 ALDH1A2 AGFG1 ATP5F1A PPP6R3	6.99e-05	934	116	12	33916271
Pubmed	MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage.	MCM8 ETAA1 PPP6R3	7.88e-05	25	116	3	32528060
Pubmed	Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.	SF3B4 SNRPA1 SNRPB2	7.88e-05	25	116	3	9731529
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TRPM4 HIP1 HIVEP2 CEP192 TRRAP EML3 FAM83H GGT7 THAP11 CELSR1 CSPG4 MARK4 PKN1	8.38e-05	1105	116	13	35748872
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	HIP1 GAK ABCB7 DDB1 VAMP3 CEP170 IPO9 PPP4C LDB1 DDX60L UQCRC2 TRMT1L SNRPA1 ATP5F1A PPP6R3	9.11e-05	1440	116	15	30833792
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	DPP7 STRN3 ACAT2 DDB1 GSS UBA1 IPO9 PPP4C AGFG1 DNM1 SNRPA1 SNRPB2 VASP TPD52 PPP6R3	1.02e-04	1455	116	15	22863883
Pubmed	G protein-coupled receptor kinase 2-mediated phosphorylation of downstream regulatory element antagonist modulator regulates membrane trafficking of Kv4.2 potassium channel.	KCNIP3 GRK2	1.10e-04	5	116	2	17102134
Pubmed	Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme.	UBA1 UBA7	1.10e-04	5	116	2	16428300
Pubmed	Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells.	ESR1 MED1	1.10e-04	5	116	2	17502350
Pubmed	Link between the causative genes of holoprosencephaly: Zic2 directly regulates Tgif1 expression.	ZIC2 ALDH1A2	1.10e-04	5	116	2	29391420
Pubmed	Variants in the GH-IGF axis confer susceptibility to lung cancer.	CAMKK1 BRCA2	1.10e-04	5	116	2	16741161
Pubmed	Estrogen receptor-dependent proteasomal degradation of the glucocorticoid receptor is coupled to an increase in mdm2 protein expression.	ESR1 TRRAP	1.10e-04	5	116	2	12897156
Pubmed	Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2.	GRK2 CSPG4	1.10e-04	5	116	2	24135140
Pubmed	Characterization of the human synaptogyrin gene family.	SYNGR3 SYNGR1	1.10e-04	5	116	2	9760194
Pubmed	Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts.	SYNGR3 SYNGR1	1.10e-04	5	116	2	31090538
Pubmed	Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine.	GRK2 GRK3	1.10e-04	5	116	2	10338466
Pubmed	The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor alpha.	ESR1 MED1	1.10e-04	5	116	2	15886699
Pubmed	AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer.	BRCA2 NFE2L2	1.10e-04	5	116	2	30733286
Pubmed	Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming.	MED1 UQCRC2 ATP5F1A	1.11e-04	28	116	3	28159809
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	STRN3 DDB1 EML3 FAM83H VPS13D IPO9 GUK1 DNM1 ATP5F1A	1.19e-04	564	116	9	21565611
Pubmed	Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy.	THAP11 UQCRC2 ATP5F1A	1.24e-04	29	116	3	35013307
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	STRN3 CAMKK1 CEP192 RAB11FIP1 CYFIP2 CEP170 CSPP1 PPP6R3	1.30e-04	446	116	8	24255178
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	HIVEP2 USP37 FAM83H ZIC2 UBA1 NFE2L2	1.33e-04	232	116	6	25515538
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	STRN3 SF3B4 INTS7 DDB1 UBA1 PPP4C SNRPA1 SNRPB2 PPP6R3	1.34e-04	573	116	9	28330616
Pubmed	Absence of canonical Smad signaling in ureteral and bladder mesenchyme causes ureteropelvic junction obstruction.	OSR2 ROBO1 MYOM2	1.52e-04	31	116	3	22282597
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	SF3B4 ABCB7 PATL1 DDB1 GGT7 CEP170 SNRPA1 ATP5F1A RBFOX2 PPP6R3	1.63e-04	725	116	10	27025967
Pubmed	beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.	GRK2 GRK3	1.64e-04	6	116	2	9826657
Pubmed	Mouse profilin 2 regulates endocytosis and competes with SH3 ligand binding to dynamin 1.	DNM1 VASP	1.64e-04	6	116	2	16319076
Pubmed	Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2.	GRK2 GRK3	1.64e-04	6	116	2	20074556
Pubmed	The role of Robo3 in the development of cortical interneurons.	RELN ROBO1	1.64e-04	6	116	2	19366869
Pubmed	The NECAP PHear domain increases clathrin accessory protein binding potential.	HIP1 NECAP1	1.64e-04	6	116	2	17762867
Interaction	CWF19L2 interactions	SF3B4 PSTPIP1 DDB1 VAMP3 S100P BRCA2 VAMP1 SNRPA1 SNRPB2	1.09e-06	182	116	9	int:CWF19L2
Interaction	SF3B5 interactions	SF3B4 CAMKK1 ESR1 USP37 TRRAP PPP4C SNRPA1 SNRPB2	1.76e-06	143	116	8	int:SF3B5
Interaction	YWHAG interactions	EHBP1 SF3B4 HIVEP2 CAMKK1 ESR1 CEP192 RAB11FIP1 USP37 TRRAP EML3 CYFIP2 FAM83H GSS CEP170 VPS13D UBA1 IPO9 MARK4 AGFG1 CSPP1 ATP5F1A PPP6R3	2.23e-06	1248	116	22	int:YWHAG
Interaction	MED16 interactions	GAK CIB2 ESR1 MED1 TRRAP DDB1 RBFOX2	6.07e-06	120	116	7	int:MED16
Interaction	AP2A1 interactions	HIP1 GAK CCDC32 ESR1 PATL1 PEX5L CYFIP2 NECAP1 DNM1 PPP6R3	9.07e-06	299	116	10	int:AP2A1
Interaction	SUPT3H interactions	ESR1 MED1 TRRAP DDB1 BRCA2	2.67e-05	61	116	5	int:SUPT3H
GeneFamily	Vesicle associated membrane proteins	VAMP3 VAMP1	3.42e-04	7	74	2	12
GeneFamily	Ubiquitin like modifier activating enzymes	UBA1 UBA7	7.28e-04	10	74	2	100
Coexpression	HE_LIM_SUN_FETAL_LUNG_C3_SCG3_POS_LYMPHATIC_ENDOTHELIAL_CELL	DPP7 B3GALT4 FAM131A ANO10 RAB11FIP1 CCDC141 EML3 ZIC2 SGK3 S100P CELSR1 ALDH1A2 PWP2 TPD52	4.80e-07	604	116	14	M45760
Coexpression	GSE7852_TREG_VS_TCONV_FAT_DN	SLC9A9 RELN HIVEP2 THAP11 ETAA1 AGFG1 KEL SNRPB2	3.14e-06	200	116	8	M5735
Coexpression	GSE20500_CTRL_VS_RARA_ANTAGONIST_TREATED_CD4_TCELL_UP	B3GALT4 ACAT2 B3GNT3 EML3 CYFIP2 CEP170 IPO9	2.66e-05	195	116	7	M7706
Coexpression	GSE29618_LAIV_VS_TIV_FLU_VACCINE_DAY7_BCELL_DN	FAM131A NXT2 ITFG1 VAMP3 IPO9 GUK1 NFE2L2	2.94e-05	198	116	7	M5013
Coexpression	KIM_ALL_DISORDERS_CALB1_CORR_UP	EHBP1 HIVEP2 FAM131A RYR2 CYFIP2 NECAP1 CEP170 UBA1 SYNGR3 UQCRC2 DNM1	3.23e-05	547	116	11	M2110
Coexpression	PATIL_LIVER_CANCER	SF3B4 INTS7 CEP192 RAB11FIP1 FAM83H ZIC2 S100P TRMT1L LSM14B SNRPA1 RBFOX2 TPD52	3.72e-05	660	116	12	M1195
Coexpression	KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP	EHBP1 RELN SF3B4 HIVEP2 FAM131A DDB1 CYFIP2 NECAP1 UBA1 SYNGR3 UQCRC2 DNM1	4.96e-05	680	116	12	M2107
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM4 CIB2 CENPT OSR2 BRCA2 PWP2 PPP6R3	3.90e-07	175	116	7	31f0fb2e47e357dbf9c15436b7df85b3c370ded7
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB CCDC141 RYR2 CYFIP2 LMOD3 SYNGR1 MYOM2	6.32e-07	188	116	7	4db566f3f708e66730aa9e16f4d73d91dc534177
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB CCDC141 RYR2 CYFIP2 LMOD3 SYNGR1 MYOM2	6.32e-07	188	116	7	6704b92991ad8c0a910e9f36cd33d00bd26dcb8f
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	SLC9A9 CCDC141 RYR2 GRK3 SYNGR3 DDX60L	5.60e-06	170	116	6	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN SPTB CYFIP2 ZIC2 VAMP1 DNM1	7.77e-06	180	116	6	6ac62bf1251978c8c12e715f7b73144fca619794
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN RGS22 RYR2 ROBO1 MYOM2 HYDIN	8.81e-06	184	116	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN RGS22 RYR2 ROBO1 MYOM2 HYDIN	8.81e-06	184	116	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN RGS22 RYR2 ROBO1 MYOM2 HYDIN	8.81e-06	184	116	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN SPTB CYFIP2 ZIC2 VAMP1 DNM1	9.37e-06	186	116	6	d1d01ce46e62944aa9864eda47e8401b5f0d2bdc
ToppCell	facs-Heart-Unknown-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB CCDC141 RYR2 LMOD3 SYNGR1 MYOM2	9.66e-06	187	116	6	0ffb988e0da2c7205c3515eca8e9851739bff5c5
ToppCell	facs-Heart-Unknown\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB CCDC141 RYR2 LMOD3 SYNGR1 MYOM2	9.66e-06	187	116	6	362e56426a568423a81e8a30e3ecf99b76135843
ToppCell	facs-Heart-Unknown-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB CCDC141 RYR2 LMOD3 SYNGR1 MYOM2	9.66e-06	187	116	6	c004567767b89f3d89f5c7b28d952f3445957e1e
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB CCDC141 RYR2 LMOD3 SYNGR1 MYOM2	9.96e-06	188	116	6	90dc0e15798d0b984518ad58c7e416e30aff687a
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB CCDC141 RYR2 LMOD3 SYNGR1 MYOM2	9.96e-06	188	116	6	f63dfd076ced81013918363282ae25cbbd8948ae
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB CCDC141 RYR2 LMOD3 SYNGR1 MYOM2	9.96e-06	188	116	6	0554d542149cef654ff1e5e32dfbffd8990b52bd
ToppCell	facs-Heart-LA/RA-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB CCDC141 RYR2 LMOD3 SYNGR1 MYOM2	1.03e-05	189	116	6	a08b2d0fa35ffa510050ecffdc68e1b79bbe1632
ToppCell	facs-Heart-LA/RA\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB CCDC141 RYR2 LMOD3 SYNGR1 MYOM2	1.03e-05	189	116	6	efa913d9c16fc32166b484d92b6449e8a0c59e03
ToppCell	facs-Heart-LV-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB RYR2 CYFIP2 LMOD3 SYNGR1 MYOM2	1.09e-05	191	116	6	543da1197c7e62f2c9cbd4a51414bbaaa6d1a92f
ToppCell	facs-Heart-LV-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB RYR2 CYFIP2 LMOD3 SYNGR1 MYOM2	1.09e-05	191	116	6	9d7d680da3979e256191b534ebd14c5383e0cf93
ToppCell	droplet-Heart-nan-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EHBP1 SPTB CCDC141 RYR2 SYNGR1 MYOM2	1.09e-05	191	116	6	97fb4232417a39801e87725755fd16a57c250209
ToppCell	droplet-Heart-nan-3m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EHBP1 SPTB CCDC141 RYR2 SYNGR1 MYOM2	1.09e-05	191	116	6	64070a309d7e3f6001272409ab9ce206d0e7d73f
ToppCell	droplet-Heart-nan-24m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EHBP1 SPTB RYR2 LMOD3 SYNGR1 MYOM2	1.12e-05	192	116	6	f6a4e348406a852ace9fb21db8fbdff539217645
ToppCell	droplet-Heart-nan-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EHBP1 SPTB RYR2 LMOD3 SYNGR1 MYOM2	1.12e-05	192	116	6	1a0c25106ae08eac912a4edd5fc1a3ee776f69c2
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HLA-DRA SGK3 CEP170 GRK3 DDX60L VASP	1.19e-05	194	116	6	69cf7c989ac355c459db13f9d4267b55adc3c174
ToppCell	Immune-alveolar_macrophage_(MARCO_positive)\|World / Lineage, Cell type, age group and donor	HLA-DRA SGK3 CEP170 GRK3 DDX60L VASP	1.23e-05	195	116	6	f92114ef995e690a3bedc62c89c5fd6773d0d9f7
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HIP1 CCDC32 RGS22 GRK3 FAM118B	2.98e-05	137	116	5	12caa8ed7cc9e7a0f78c14ad5efe2fc28c3ce9be
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SLC9A9 ESR1 FAM131A IPO9 ZNF788P	3.65e-05	143	116	5	8f897278f9ccc82ae35e4f30c5f930b2a3eb509d
ToppCell	droplet-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UGT3A1 CCDC141 SAA1 HPD SLC25A15	4.89e-05	152	116	5	c21e2152b0130485659051d8fb7fb4589d1ec997
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Fibroblasts-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABAT CIB2 CDH23 RYR2 CFAP44	5.87e-05	158	116	5	7f5426585d0d299d2b48e5fcb349950feffdef33
ToppCell	COVID-19-APC-like-Monocytes\|COVID-19 / group, cell type (main and fine annotations)	MCM8 FAM131A LZIC EML3 GRK2	5.87e-05	158	116	5	a0d94bd067424783863a48db20976d4c2043600c
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D122\|Adult / Lineage, Cell type, age group and donor	SPTB PEX5L ADCY5 RYR2 MYOM2	6.23e-05	160	116	5	fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB CCDC141 RYR2 SYNGR1 MYOM2	8.77e-05	172	116	5	ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB CCDC141 RYR2 SYNGR1 MYOM2	8.77e-05	172	116	5	bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCell	Bronchial_Brush-Epithelial-Ionocytes\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	UGT3A1 ADCY5 SYNGR3 PNMA6A ADAMTSL2	9.01e-05	173	116	5	e1de849dcd96063136bdac87e050ddbd55cabdcc
ToppCell	Bronchial_Brush-Epithelial-Ionocytes\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	UGT3A1 ADCY5 SYNGR3 PNMA6A ADAMTSL2	9.01e-05	173	116	5	f2a8f4918c1fb68d98bc3f33cd624de0f0f11e06
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC9A9 HIVEP2 SPTB ADCY5 CEP170	9.51e-05	175	116	5	f24b664b9056b5976bf2222e8013f15c09e049ad
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A9 RELN MID2 CCDC141 DCHS1	1.00e-04	177	116	5	c274fbdc141855ff4581d437d4997c64cc193278
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A9 RELN MID2 CCDC141 DCHS1	1.00e-04	177	116	5	f5e6df5cafd003bbfbb3b634ee58d0b1e2be5cc7
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A9 RELN MID2 CCDC141 DCHS1	1.00e-04	177	116	5	c8a51e480b978dc0ded85583261f2c892e085be8
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-11\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ABAT CCDC32 HLA-DRA USP37 CFAP44	1.00e-04	177	116	5	3535575686c9700ab72700aae6f2070ebbb50044
ToppCell	facs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCB7 CAMKK1 B3GNT3 PWP2 RBFOX2	1.09e-04	180	116	5	7368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCell	IIH-plasma\|IIH / Condition, Cell_class and T cell subcluster	RELN ZIC2 ROBO1 PNMA6A HYDIN	1.11e-04	181	116	5	13d1f31bcbac21aea91de74f51eed549ec61003e
ToppCell	IIH-plasma-\|IIH / Condition, Cell_class and T cell subcluster	RELN ZIC2 ROBO1 PNMA6A HYDIN	1.11e-04	181	116	5	140ac43dc6b89396872f908c14c89278f6d982b2
ToppCell	Adult-Mesenchymal-pericyte_cell-D122\|Adult / Lineage, Cell type, age group and donor	SPTB KCNIP3 ADCY5 RYR2 CSPG4	1.17e-04	183	116	5	fc31a43a637423cb3bb9aa184a3a889a0b9aaea6
ToppCell	COVID-19-Heart-CM_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SPTB CCDC141 ADCY5 RYR2 MYOM2	1.20e-04	184	116	5	e737f0f14c49b07bbb04a165083ac32210bc5690
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SPTB CCDC141 ADCY5 RYR2 MYOM2	1.23e-04	185	116	5	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCDC141 ZIC2 S100P CELSR1 ALDH1A2	1.23e-04	185	116	5	241ea1e178fffef9e7df971de739e794332d5173
ToppCell	droplet-Bladder-nan-24m-Endothelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN HIP1 FAM131A ADCY5 CSPG4	1.23e-04	185	116	5	90caab8d9361a541c5d5121c97c3f1cdffeeae4a
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	HIVEP2 FAM131A KCNIP3 PEX5L RYR2	1.27e-04	186	116	5	56c139e679d640ea901ead657a8e8887e0fca098
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB CCDC141 RYR2 SYNGR1 MYOM2	1.27e-04	186	116	5	337f768cc43db2db96ba6495b076006b1a5b0331
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTB CCDC141 RYR2 SYNGR1 MYOM2	1.27e-04	186	116	5	e378c82ef6d6cb24751515aa499a01372b3e7ccf
ToppCell	Adult-Mesenchymal-pericyte_cell\|Adult / Lineage, Cell type, age group and donor	SPTB KCNIP3 ADCY5 RYR2 CSPG4	1.30e-04	187	116	5	62759efb660179402fb574ce5701c89a2e17bcfe
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 FAM131A RYR2 CYFIP2 DNM1	1.30e-04	187	116	5	e04a84989d624378141042768383b9c846901f2d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 FAM131A RYR2 CYFIP2 DNM1	1.30e-04	187	116	5	24cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 FAM131A RYR2 CYFIP2 DNM1	1.30e-04	187	116	5	2f153b203fe79f206319603cf94d3a03ab49a05d
ToppCell	B_cells-Naive_B_cells_\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	HLA-DRA RAB11FIP1 CYFIP2 CELSR1 TPD52	1.33e-04	188	116	5	d1bc1316bbb8cfc39acc70f8680b14d19f536997
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RELN ADCY5 ALDH1A2 ROBO1 DNM1	1.33e-04	188	116	5	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-B_cell-B_cell\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MID2 CELSR1 ADPRM SYNGR3 CFAP44	1.33e-04	188	116	5	99fdd305f75ed38dd507e7a17ffe27c26b86e454
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RELN ADCY5 ALDH1A2 ROBO1 DNM1	1.33e-04	188	116	5	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-B_cell\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MID2 CELSR1 ADPRM SYNGR3 CFAP44	1.33e-04	188	116	5	5a0519b189e96001d95f9d24363448e8602b8d4d
ToppCell	MS-CD8-CD4_Treg\|MS / Condition, Cell_class and T cell subcluster	INTS7 USP37 VAMP3 THAP11 BRCA2	1.33e-04	188	116	5	2f0e2c7d79ee2d69a5d908c0247dc950c056c30a
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-B_cell-B_cell-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MID2 CELSR1 ADPRM SYNGR3 CFAP44	1.33e-04	188	116	5	e8b7c1c2eb2e390ad79b358236468b0f15ea58a5
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN SPTB CYFIP2 VAMP1 DNM1	1.36e-04	189	116	5	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SPTB ADCY5 RYR2 ALDH1A2 MYOM2	1.40e-04	190	116	5	d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC9A9 RYR2 ALDH1A2 GRK3 ROBO1	1.43e-04	191	116	5	b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCell	Control-Stromal-SMC\|Stromal / Disease state, Lineage and Cell class	HIP1 SPTB ADCY5 CYFIP2 CSPG4	1.43e-04	191	116	5	2da83c493e60ad0278848957645277d76737a188
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	RELN HIVEP2 RAB11FIP1 ALDH1A2 PKN1	1.47e-04	192	116	5	b016e229300c183e14c0e2bba494bf49c7899112
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HIP1 ADCY5 RYR2 CSPG4 MYOM2	1.47e-04	192	116	5	bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCell	368C-Endothelial_cells-Endothelial-F_(Lymphatics)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	RELN HIVEP2 RAB11FIP1 ALDH1A2 PKN1	1.47e-04	192	116	5	ac96831492c62ad9e1f7d0b764fbdf7d8a189ad9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HIP1 ADCY5 RYR2 CSPG4 MYOM2	1.47e-04	192	116	5	b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	INTS7 OSR2 USP37 IPO9 HYDIN	1.47e-04	192	116	5	d6f656be2698bd215717d35f4e7ab727c08c61e0
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D122\|Adult / Lineage, Cell type, age group and donor	SGK3 CEP170 ALDH1A2 GRK3 VASP	1.50e-04	193	116	5	cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCell	LA\|World / Chamber and Cluster_Paper	EHBP1 SLC9A9 SAA1 ROBO1 DNM1	1.50e-04	193	116	5	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN SPTB CYFIP2 VAMP1 DNM1	1.50e-04	193	116	5	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	15-Airway-Mesenchymal-Pericyte\|Airway / Age, Tissue, Lineage and Cell class	HIP1 SPTB ALDH1A2 CSPG4 MYOM2	1.54e-04	194	116	5	5c1218d239c88082496924653ed2a092dc44a906
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RGS22 SAA1 CFAP44 CSPP1 HYDIN	1.54e-04	194	116	5	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A9 HLA-DRA CCDC141 CEP170 GRK3	1.58e-04	195	116	5	247803cf58c6d9c561a52aa34e581188ddad197e
ToppCell	10x3'2.3-week_14-16-Hematopoietic-erythroid\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	RELN SPTB LDB1 SYNGR1 KEL	1.58e-04	195	116	5	b24f6fe71fbcffe7ff1fd1374455c378837d6313
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ANO10 RYR2 SYNGR1 MYOM2	1.64e-04	105	116	4	8f31edf4183587f5b53941475453c5aa49f10bbd
ToppCell	Control_saline-Epithelial_alveolar-AT_2-Differentiating_AT2\|Control_saline / Treatment groups by lineage, cell group, cell type	CCDC141 CYFIP2 S100P CELSR1 LGI3	1.66e-04	197	116	5	44a59dfb889577b3160a5b13ada1276771a00241
ToppCell	Control-Classical_Monocyte-cMono_2\|Classical_Monocyte / Disease condition and Cell class	RAB11FIP1 GRK2 GRK3 VASP ATP5F1A	1.66e-04	197	116	5	eb7610c9496a95a5fd866e16abcbc39b83abe617
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLC9A9 OSR2 ROBO1 DNM1 ADAMTSL2	1.66e-04	197	116	5	44673c38384453207871d3fd8e8ba9093cc06bc5
ToppCell	Control-gd_T\|Control / Disease condition and Cell class	HLA-DRA GRK2 GUK1 SYNGR1 PKN1	1.66e-04	197	116	5	000b3269c152d80527b5ad9412dd4e71b73ef1ca
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ACAT2 CCDC141 CYFIP2 S100P LGI3	1.66e-04	197	116	5	1638959d7aecb9fc5285eb7e4a3103ca437989e2
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADCY5 RYR2 SAA1 CSPG4 MYOM2	1.69e-04	198	116	5	f261a37dd07976548b897af86df1d1a0dc069889
ToppCell	COVID-19-Myeloid\|COVID-19 / group, cell type (main and fine annotations)	HLA-DRA SGK3 CEP170 ALDH1A2 GRK3	1.69e-04	198	116	5	33f0a919188a67d2a876b52c61a1cec2c9747969
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-B-B_memory\|ICU-NoSEP / Disease, condition lineage and cell class	HLA-DRA CCDC141 RYR2 ROBO1 TPD52	1.73e-04	199	116	5	acd2b87ab0d7d92515cf46ab65b766d6ade818a6
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-neutrophil-myelocyte\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PSTPIP1 S100P AP5B1 PKN1 VASP	1.73e-04	199	116	5	a1635a52318be0423f8e4fc03d971c28cd22b57e
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADCY5 RYR2 ALDH1A2 CSPG4 MYOM2	1.73e-04	199	116	5	b768496381362f9a2706e0892b5a7a0db82e09ce
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_basal-Dividing_Basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CIB2 B3GNT3 S100P SAA1 CELSR1	1.73e-04	199	116	5	f0c289523957258d16135c04679db379d43d28d9
ToppCell	Control-Control-Myeloid-immature_Neutrophil\|Control / Disease, condition lineage and cell class	MCM8 S100P VAMP1 TRMT1L LSM14B	1.78e-04	200	116	5	118321ac443feb42aee171baccfc4610f00a8822
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial-Proteoglycan-expressing_cell\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	CDH23 HS1BP3 LMOD3 UBA7 CSPG4	1.78e-04	200	116	5	aafe594c88710f8c53d59667cdac5035e08f5511
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Intermediate\|10w / Sample Type, Dataset, Time_group, and Cell type.	CIB2 FAM131A PEX5L ZIC2 RBFOX2	1.78e-04	200	116	5	e5a8647c47a49c8c90c78d681193946de103d8ff
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_only / Treatment groups by lineage, cell group, cell type	ADCY5 RYR2 CSPG4 ROBO1 CSPP1	1.78e-04	200	116	5	69edc375d85689300d1dbc1217fedc40063ecdcb
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	CDH23 HS1BP3 LMOD3 UBA7 CSPG4	1.78e-04	200	116	5	a6f0f5f644b7262878b0b9d4d90ee407c4124dd9
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Intermediate\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	TRPM4 ZIC2 BRCA2 DDX60L TPD52	1.78e-04	200	116	5	fe772d98c461c973dfc082e1fc50117c27ced804
Drug	L-Ft	ABAT ESR1 GGT7 UBA7 BRCA2 HPD KEL	1.45e-07	78	116	7	CID000451514
Drug	Hydralazine hydrochloride [304-20-1]; Down 200; 20.4uM; MCF7; HT_HG-U133A	TRPM4 INTS7 ESR1 FAM131A RYR2 GRK3 SYNGR1 KEL VASP	7.14e-07	195	116	9	2311_DN
Drug	Thiamphenicol [15318-45-3]; Down 200; 11.2uM; MCF7; HT_HG-U133A	STRN3 HIVEP2 CENPT ESR1 ADPRM GRK2 ROBO1 PKN1	6.71e-06	193	116	8	7033_DN
Drug	Flunisolide [3385-03-3]; Down 200; 9.2uM; PC3; HT_HG-U133A	EHBP1 TRPM4 HIVEP2 ESR1 EML3 LDB1 AGFG1 PPP6R3	6.96e-06	194	116	8	3747_DN
Drug	Tolnaftate [2398-96-1]; Down 200; 13uM; HL60; HG-U133A	HS1BP3 TRRAP NXT2 GSS VAMP3 VPS13D GRK2 UQCRC2	6.96e-06	194	116	8	2001_DN
Drug	Sulfaguanidine [57-67-0]; Down 200; 18.6uM; MCF7; HT_HG-U133A	ESR1 B3GNT3 RYR2 ADPRM GRK2 LDB1 MARK4 CFAP44	6.96e-06	194	116	8	4839_DN
Drug	Nefopam hydrochloride [23327-57-3]; Down 200; 13.8uM; MCF7; HT_HG-U133A	ESR1 EML3 VPS13D IPO9 GRK2 MARK4 KEL DNM1	7.23e-06	195	116	8	2317_DN
Drug	Rolitetracycline [751-97-3]; Down 200; 7.6uM; MCF7; HT_HG-U133A	HIVEP2 MED1 NXT2 GRK3 SYNGR3 ROBO1 PKN1 DNM1	7.51e-06	196	116	8	5331_DN
Drug	Pirenzepine dihydrochloride [29868-97-1]; Down 200; 9.4uM; HL60; HG-U133A	EHBP1 GAK MID2 MED1 EML3 VPS13D SYNGR1 AGFG1	7.79e-06	197	116	8	1388_DN
Drug	Methotrimeprazine maleat salt [7104-38-3]; Down 200; 9uM; MCF7; HT_HG-U133A	EHBP1 STRN3 CENPT ESR1 FAM131A EML3 LDB1 MARK4	8.09e-06	198	116	8	3440_DN
Drug	clozapine; Up 200; 10uM; MCF7; HT_HG-U133A_EA	HIP1 CENPT ESR1 B3GNT3 EML3 LDB1 SYNGR1 CFAP44	8.39e-06	199	116	8	1009_UP
Drug	phosphine oxide	GAK RYR2 GSS PPP4C GRK2 GRK3	1.83e-05	107	116	6	CID000166931
Drug	diethyl phosphate	HIP1 GAK ESR1 ALDH1A2 HPD AGFG1	3.34e-05	119	116	6	CID000000654
Drug	Prochlorperazine dimaleate [84-02-6]; Down 200; 6.6uM; MCF7; HT_HG-U133A	STRN3 HIP1 ESR1 TRRAP NXT2 CSPP1 RBFOX2	4.78e-05	186	116	7	5010_DN
Drug	Thioguanosine [85-31-4]; Down 200; 12.6uM; MCF7; HT_HG-U133A	VPS13D GRK3 BRCA2 VAMP1 AGFG1 ROBO1 TRMT1L	5.47e-05	190	116	7	2619_DN
Drug	Diphenylpyraline hydrochloride [132-18-3]; Down 200; 12.6uM; PC3; HT_HG-U133A	TRRAP NXT2 VAMP3 ADPRM GRK2 RBFOX2 TPD52	5.65e-05	191	116	7	4299_DN
Drug	Ketanserin tartrate hydrate [83846-83-7]; Down 200; 7uM; MCF7; HT_HG-U133A	HIP1 ESR1 NXT2 RYR2 VAMP3 AGFG1 RBFOX2	6.03e-05	193	116	7	3209_DN
Drug	Cotinine (-) [486-56-6]; Down 200; 22.6uM; PC3; HT_HG-U133A	FAM131A DDB1 EML3 VPS13D LDB1 BRCA2 CSPP1	6.03e-05	193	116	7	4650_DN
Drug	Felodipine [72509-76-3]; Down 200; 10.4uM; PC3; HT_HG-U133A	OSR2 EML3 RYR2 GRK3 BRCA2 SYNGR3 ETAA1	6.23e-05	194	116	7	6695_DN
Drug	Chlorpropamide [94-20-2]; Down 200; 14.4uM; MCF7; HT_HG-U133A	STRN3 INTS7 ESR1 NXT2 VAMP3 IPO9 TPD52	6.44e-05	195	116	7	3210_DN
Drug	Hemicholinium bromide [312-45-8]; Down 200; 7uM; MCF7; HT_HG-U133A	ESR1 HS1BP3 MED1 NXT2 VAMP3 ETAA1 DNM1	6.44e-05	195	116	7	5339_DN
Drug	Ribostamycin sulfate salt [53797-35-6]; Down 200; 7.2uM; HL60; HT_HG-U133A	MED1 EML3 CELSR1 LDB1 VAMP1 ETAA1 RBFOX2	6.44e-05	195	116	7	2705_DN
Drug	Felodipine [72509-76-3]; Down 200; 10.4uM; MCF7; HT_HG-U133A	HIP1 ESR1 RYR2 VPS13D GRK2 LDB1 MARK4	6.44e-05	195	116	7	3295_DN
Drug	Clomiphene citrate (Z,E) [50-41-9]; Down 200; 6.6uM; MCF7; HT_HG-U133A	CENPT ESR1 DDB1 EML3 AGFG1 LSM14B CSPP1	6.44e-05	195	116	7	4994_DN
Drug	oxaprozin; Down 200; 300uM; MCF7; HT_HG-U133A_EA	STRN3 HIP1 INTS7 ESR1 MED1 GRK3 BRCA2	6.44e-05	195	116	7	863_DN
Drug	Beta-sistosterol [83-46-5]; Down 200; 9.6uM; PC3; HT_HG-U133A	ESR1 OSR2 EML3 RYR2 GRK2 SYNGR1 MARK4	6.44e-05	195	116	7	4073_DN
Drug	Midodrine hydrochloride [3092-17-9]; Down 200; 13.8uM; HL60; HG-U133A	GAK GSS VPS13D SYNGR1 MARK4 AGFG1 DNM1	6.65e-05	196	116	7	1403_DN
Drug	Antazoline hydrochloride [2508-72-7]; Down 200; 13.2uM; MCF7; HT_HG-U133A	TRPM4 HS1BP3 B3GNT3 EML3 CYFIP2 SYNGR1 ETAA1	6.65e-05	196	116	7	6775_DN
Drug	Sulfamonomethoxine [1220-83-3]; Up 200; 14.2uM; MCF7; HT_HG-U133A	TRPM4 STRN3 INTS7 ESR1 NXT2 ADPRM TPD52	6.65e-05	196	116	7	7200_UP
Drug	Azaperone [1649-18-9]; Down 200; 12.2uM; PC3; HT_HG-U133A	GAK CIB2 HS1BP3 VPS13D SYNGR1 MARK4 TRMT1L	6.65e-05	196	116	7	5877_DN
Drug	Pimozide [2062-78-4]; Down 200; 8.6uM; MCF7; HT_HG-U133A	ESR1 IPO9 GRK2 MARK4 VAMP1 ETAA1 CSPP1	6.65e-05	196	116	7	3178_DN
Drug	Thioridazine hydrochloride [130-61-0]; Down 200; 9.8uM; MCF7; HT_HG-U133A	TRPM4 ESR1 EML3 CYFIP2 GRK3 SYNGR1 MARK4	6.87e-05	197	116	7	1486_DN
Drug	Loracarbef [121961-22-6]; Down 200; 10.8uM; MCF7; HT_HG-U133A	TRPM4 VPS13D IPO9 GRK2 GRK3 SYNGR1 MARK4	6.87e-05	197	116	7	3532_DN
Drug	2-propylpentanoic acid; Down 200; 50uM; PC3; HT_HG-U133A	TRPM4 CIB2 CENPT GRK2 PKN1 DNM1 CFAP44	6.87e-05	197	116	7	1222_DN
Drug	Alprostadil [745-65-3]; Down 200; 11.2uM; MCF7; HT_HG-U133A	STRN3 ESR1 VPS13D GRK3 BRCA2 SYNGR1 CSPP1	6.87e-05	197	116	7	7358_DN
Drug	Skimmianine [83-95-4]; Down 200; 15.4uM; PC3; HT_HG-U133A	B3GNT3 RAB11FIP1 EML3 VPS13D GRK2 BRCA2 MARK4	6.87e-05	197	116	7	5766_DN
Drug	Thioproperazine dimesylate [2347-80-0]; Down 200; 6.2uM; PC3; HT_HG-U133A	CIB2 ESR1 RYR2 CYFIP2 VPS13D LSM14B CFAP44	6.87e-05	197	116	7	5791_DN
Drug	Picrotoxinin [17617-45-7]; Down 200; 13.6uM; MCF7; HT_HG-U133A	HIP1 ESR1 EML3 ADPRM GRK2 ETAA1 CSPP1	6.87e-05	197	116	7	4842_DN
Drug	Minoxidil [38304-91-5]; Down 200; 19.2uM; MCF7; HT_HG-U133A	TRPM4 MID2 ESR1 FAM131A MED1 EML3 MARK4	6.87e-05	197	116	7	1496_DN
Drug	Pheniramine maleate [132-20-7]; Down 200; 11.2uM; HL60; HG-U133A	ABCB7 TRRAP VAMP3 GRK2 SLC25A15 AGFG1 RBFOX2	6.87e-05	197	116	7	1992_DN
Drug	aspirin, USP; Down 200; 100uM; MCF7; HT_HG-U133A	EML3 CYFIP2 LDB1 SYNGR3 ETAA1 ROBO1 PKN1	6.87e-05	197	116	7	5564_DN
Drug	Isotretinoin [4759-48-2]; Down 200; 13.4uM; MCF7; HT_HG-U133A	FAM131A EML3 LDB1 SYNGR3 SYNGR1 ETAA1 TPD52	6.87e-05	197	116	7	6017_DN
Drug	Ketoconazole [65277-42-1]; Down 200; 7.6uM; MCF7; HT_HG-U133A	HIP1 ESR1 EML3 VPS13D GRK3 CSPP1 TPD52	6.87e-05	197	116	7	5685_DN
Drug	alpha-estradiol; Down 200; 0.01uM; MCF7; HT_HG-U133A	ESR1 NXT2 EML3 GRK2 SYNGR1 LSM14B RBFOX2	6.87e-05	197	116	7	1635_DN
Drug	Reserpinic acid hydrochloride; Down 200; 9.2uM; MCF7; HT_HG-U133A	ABAT ESR1 RYR2 SYNGR1 LSM14B CSPP1 TPD52	7.09e-05	198	116	7	7323_DN
Drug	5149715; Down 200; 10uM; MCF7; HT_HG-U133A_EA	STRN3 ESR1 EML3 CYFIP2 LDB1 LSM14B RBFOX2	7.09e-05	198	116	7	890_DN
Drug	thioridazine hydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A	TRPM4 GRK3 LDB1 SYNGR1 PKN1 DNM1 TPD52	7.09e-05	198	116	7	1655_DN
Drug	Bezafibrate [41859-67-0]; Down 200; 11uM; MCF7; HT_HG-U133A	HIP1 ESR1 IPO9 GRK2 GRK3 ETAA1 RBFOX2	7.09e-05	198	116	7	4999_DN
Drug	Sulpiride [15676-16-1]; Down 200; 11.8uM; PC3; HG-U133A	MID2 ITFG1 VAMP3 IPO9 UQCRC2 RBFOX2 TPD52	7.09e-05	198	116	7	1887_DN
Drug	Hexylcaine hydrochloride [532-76-3]; Down 200; 13.4uM; MCF7; HT_HG-U133A	ESR1 RYR2 VPS13D IPO9 ETAA1 ROBO1 DNM1	7.32e-05	199	116	7	6244_DN
Drug	Naftopidil dihydrochloride [57149-08-3]; Down 200; 8.6uM; MCF7; HT_HG-U133A	HIP1 ESR1 ANO10 VPS13D SYNGR1 ETAA1 DNM1	7.32e-05	199	116	7	7331_DN
Drug	Griseofulvin [126-07-8]; Down 200; 11.2uM; MCF7; HT_HG-U133A	HIP1 ESR1 UBA7 BRCA2 SYNGR3 MARK4 ETAA1	7.32e-05	199	116	7	4687_DN
Drug	epithiostanol	ESR1 KEL	7.69e-05	3	116	2	CID000003243
Drug	cyclopropyl	ABAT ESR1 PPP4C HPD	8.11e-05	45	116	4	CID000123162
Drug	Desipramine	CAMKK1 GRK2 GRK3 NFE2L2	9.63e-05	47	116	4	ctd:D003891
Drug	AC1OAGFB	TRPM4 SLC9A9 SPTB CDH23 TRRAP ADCY5 GRK2 GRK3 PKN1 DNM1 VASP	9.89e-05	539	116	11	CID006857345
Drug	dicofol	ESR1 AGFG1 KEL	9.94e-05	18	116	3	CID000008268
Drug	8-azidoadenosine	RELN GRK2 GRK3	1.18e-04	19	116	3	CID000160751
Drug	botulinum toxin type D	VAMP3 VAMP1	1.53e-04	4	116	2	ctd:C096325
Drug	AC1LAIK6	PSTPIP1 CEP170 GRK2 GRK3 RBFOX2	1.69e-04	101	116	5	CID000469113
Disease	body height at birth	SF3B4 HIVEP2 ESR1 ADCY5	1.68e-05	40	113	4	EFO_0006784
Disease	bipolar disorder (is_marker_for)	RELN HLA-DRA GRK3	5.07e-05	19	113	3	DOID:3312 (is_marker_for)
Disease	disease progression measurement	HIVEP2 CDH23 ADCY5 CELSR1	8.99e-05	61	113	4	EFO_0008336
Disease	connective tissue disease (is_implicated_in)	SNRPA1 SNRPB2	1.44e-04	5	113	2	DOID:65 (is_implicated_in)
Disease	GlcNAc sulfate conjugate of C21H34O2 steroid measurement	UGT3A1 CELSR1	2.16e-04	6	113	2	EFO_0800663
Disease	Usher Syndrome, Type I	CIB2 CDH23	2.16e-04	6	113	2	C1568247
Disease	oligoasthenoteratozoospermia (implicated_via_orthology)	PPP4C AGFG1	2.16e-04	6	113	2	DOID:0070311 (implicated_via_orthology)
Disease	hypertension (biomarker_via_orthology)	ADCY5 GRK2 GRK3 NFE2L2 ATP5F1A RBFOX2	2.47e-04	227	113	6	DOID:10763 (biomarker_via_orthology)
Disease	infertility (implicated_via_orthology)	ESR1 BRCA2	3.01e-04	7	113	2	DOID:5223 (implicated_via_orthology)
Disease	Adenocarcinoma of large intestine	TRRAP GRK2 MARK4 PKN1	5.16e-04	96	113	4	C1319315
Disease	Prostatic Neoplasms	EHBP1 TRPM4 ESR1 ZIC2 ALDH1A2 BRCA2 NFE2L2 ROBO1 TPD52	6.19e-04	616	113	9	C0033578
Disease	Malignant neoplasm of prostate	EHBP1 TRPM4 ESR1 ZIC2 ALDH1A2 BRCA2 NFE2L2 ROBO1 TPD52	6.19e-04	616	113	9	C0376358
Disease	Uterine leiomyoma, estrogen-receptor negative breast cancer	MCM8 ESR1	6.41e-04	10	113	2	EFO_1000650, HP_0000131
Disease	apolipoprotein B measurement	EHBP1 HLA-DRA HS1BP3 ALDH1A2 BRCA2 MARK4 HYDIN VASP FAM118B	1.04e-03	663	113	9	EFO_0004615
Disease	lysophosphatidylcholine 15:0 measurement	PATL1 ALDH1A2	1.28e-03	14	113	2	EFO_0020941
Disease	Alzheimer's disease (biomarker_via_orthology)	NFE2L2 DNM1 ATP5F1A	1.45e-03	58	113	3	DOID:10652 (biomarker_via_orthology)
Disease	Alzheimer's disease (is_implicated_in)	ABAT ESR1 GSS NFE2L2	1.69e-03	132	113	4	DOID:10652 (is_implicated_in)
Disease	Holoprosencephaly	PSTPIP1 ZIC2	1.90e-03	17	113	2	C0079541
Disease	Uterine leiomyoma, estrogen-receptor positive breast cancer	MCM8 ESR1	2.14e-03	18	113	2	EFO_1000649, HP_0000131
Disease	schizophrenia (implicated_via_orthology)	RELN HIVEP2 ZIC2	2.29e-03	68	113	3	DOID:5419 (implicated_via_orthology)
Disease	cytomegalovirus virus reactivation, response to allogeneic hematopoietic stem cell transplant	CDH23 DEFA6	2.38e-03	19	113	2	EFO_0007044, EFO_0020106
Disease	toxic shock syndrome (is_marker_for)	HLA-DRA GRK2	2.38e-03	19	113	2	DOID:14115 (is_marker_for)
Disease	exercise test	RYR2 ALDH1A2	2.64e-03	20	113	2	EFO_0004328
Disease	BREAST CANCER	ESR1 BRCA2	2.91e-03	21	113	2	114480
Disease	Ovarian Failure, Premature	MCM8 NFE2L2	2.91e-03	21	113	2	C0085215
Disease	Autistic Disorder	SLC9A9 RELN ABAT TRRAP ROBO1	3.37e-03	261	113	5	C0004352

Protein segments in the cluster

Peptide	Gene	Start	Entry
DALQAGASQFETSAA	VAMP3	51	Q15836
LAQEFSDFLNFDSSG	C2orf42	261	Q9NWW7
AAAEFENAESEADFS	CEP170	1551	Q5SW79
EVNAADAFDIGSFDE	GRK3	476	P35626
DVAFSDADSGFADAQ	CSPG4	1041	Q6UVK1
ERANNSDFGLVAAVF	ALDH1A2	436	O94788
SDFGLVAAVFTNDIN	ALDH1A2	441	O94788
ESAAQGDILQAAFQD	B3GALT4	131	O96024
VQFADLEDGFNFQGT	ADPRM	26	Q3LIE5
QGFDLAATQDADFHE	CELSR1	2171	Q9NYQ6
DNADLLVTANAIDFF	ADCY5	956	O95622
FRALANDSEDVGQVF	CDH23	2891	Q9H251
AGADGNIFVFNIFSE	CFAP44	876	Q96MT7
REVAAFAQFGSDLDA	ATP5F1A	441	P25705
EVNAADAFDIGSFDE	GRK2	476	P25098
NFDNDLIFQAESFGE	RAD21L1	146	Q9H4I0
FVAESAVAGSAEANA	UQCRC2	271	P22695
GFGFVTFENSADADR	RBFOX2	161	O43251
DNVEVEAAVFAAANF	INTS7	151	Q9NVH2
AAANFSAQSKDFAVG	INTS7	161	Q9NVH2
QNFKGFDDNNDDFLT	ANO10	106	Q9NW15
ADDAEQAFERISANG	PSTPIP1	151	O43586
QFNDDTFGSGAVDDD	PATL1	31	Q86TB9
QVFASDADAGVNGAV	DCHS1	276	Q96JQ0
TADDEAFLSANAGAI	LZIC	146	Q8WZA0
FDAANGIDDEDSFNN	LDB1	366	Q86U70
VADFENFIGSLNDQG	MCM8	811	Q9UJA3
TFSLANVGADENVAF	LMOD3	286	Q0VAK6
LQDAFSAIGQNADLD	DNM1	16	Q05193
IADFGVSNQFEGNDA	CAMKK1	291	Q8N5S9
GDFDFESANAQFNRE	LSM14B	251	Q9BX40
QSEGGDNHASDDFFR	ABAT	296	P80404
NDFVESNFFVIDGDS	DDX60L	31	Q5H9U9
EGAAYEFNAAAAANA	ESR1	56	P03372
AFAAAVAQDGFNVTH	GGT7	256	Q9UJ14
LSGEFNRAIDAFNAA	PEX5L	486	Q8IYB4
LNSDATVNTDFGDEF	NFE2L2	271	Q16236
GLDAATFQNVHDFNE	CSPP1	1001	Q1MSJ5
EFFSANAISDQLLGA	ADAMTSL2	451	Q86TH1
KAAFGEALFTAQDEA	AP5B1	331	Q2VPB7
NFDTNFEDRNAFVTG	CYFIP2	41	Q96F07
FDFANLAVAATQEDP	OSR2	116	Q8N2R0
AVNEDSFLQIDFAAS	RELN	2371	P78509
QIAEAAFNAIFDGST	ETAA1	276	Q9NY74
SENDFEDLLSNQGFS	GAK	1176	O14976
VVFDGLDTLFAQNAA	HYDIN	2231	Q4G0P3
AAGDFIEHAEFSGNL	GUK1	66	Q16774
TDSQTGNDEEAFDFF	HS1BP3	156	Q53T59
NEFFNSANKAFDVLG	CCDC141	356	Q6ZP82
QRGANDQDFAVSFAE	DEFA6	41	Q01524
EANAFEAPLTFANAD	BRCA2	621	P51587
LAGEAEEVNAFALGF	CENPT	296	Q96BT3
GEQEARFAAGVAEQF	FAM131A	161	Q6UXB0
FASFEAQGALANIAV	HLA-DRA	76	P01903
ANASFVLNGDDDVFA	B3GNT3	201	Q9Y2A9
DFLSQDDSVFVNDSG	EHBP1	606	Q8NDI1
AEANIKIADFGFSNE	MARK4	191	Q96L34
SDNFHDANANRGGFD	CEP192	371	Q8TEP8
QEDGANNAFSDSFVD	CCDC32	31	Q9BV29
SQASDIDEIFGFFND	FAM118B	6	Q9BPY3
TDFQNESAAALAAAA	IPO9	411	Q96P70
AFSAADQGAFLCVVD	EML3	366	Q32P44
SFATEGAGAVENFAA	FAM83H	411	Q6ZRV2
DFNLLVDAVSQNAAF	GSS	71	P48637
NAFDADGNGAIHFED	KCNIP3	136	Q9Y2W7
FVEFENDGQAGAARD	SNRPB2	191	P08579
QELGSDERAFAFDGF	RYR2	1126	Q92736
VNASVLEADDAFVGF	SGK3	471	Q96BR1
DDDNFLGAENAFNLF	DDB1	961	Q16531
NNSAFVAELAAERGA	DPP7	86	Q9UHL4
GDSNQFFRDVTADFE	DPP7	196	Q9UHL4
DNDDFKGFASQALNT	MED1	891	Q15648
NAVSGLDALNNFFDT	NXT2	51	Q9NPJ8
NFEGNFESLDLAEFA	FUNDC2	46	Q9BWH2
AGNFNSLFKAFEEEQ	HPD	361	P32754
FSEQLFTEEAVAGAA	RAB11FIP1	811	Q6WKZ4
SGDVLETFNFLENAD	STRN3	241	Q13033
LENLAFVTDGNFDSA	TRMT1L	91	Q7Z2T5
DDRADALQAGASQFE	VAMP1	66	P23763
ENPNAFDAAAFFQSV	SLC9A9	261	Q8IVB4
NLGATLDQFDAIDFS	SNRPA1	36	P09661
RFNADYGVFEVANDA	RGS22	46	Q8NE09
DEAGESDVNNFFQLT	HIP1	171	O00291
AAEQAAFLDFDFVAG	PKN1	926	Q16512
DLQNAAAGSFASAFA	SLC25A15	106	Q9Y619
AALAQVFGDNESQAT	PNMA6A	226	P0CW24
FFGHGAEDSLADQAA	SAA1	86	P0DJI8
AGAAFFNEVRNAVFG	ABCB7	201	O75027
AAQNSANADFANFDA	AGFG1	231	P52594
ANADFANFDAFGQSS	AGFG1	236	P52594
AAFSEDGEGNLTFND	CIB2	76	O75838
QDLDNFIANFGDAGF	UGT3A1	281	Q6NUS8
DIFEINEAFAAVSAA	ACAT2	316	Q9BWD1
DNFFSRVDGVAAALD	UBA7	526	P41226
FFNKEGDFNNLTAAA	PWP2	281	Q15269
LDANGDAQVDFSEFI	S100P	61	P25815
NEGTDAARAAIAFSF	SYNGR1	141	O43759
SFFTDADFAQAVAAA	ROBO1	1396	Q9Y6N7
ADFAQAVAAAAEYAG	ROBO1	1401	Q9Y6N7
AQDNFGYDLAAVEAA	SPTB	446	P11277
DAENFFQFQGDADDL	SPTB	741	P11277
QAGDAARAAIAFSFF	SYNGR3	141	O43761
DDDFFQNLDGVANAL	UBA1	561	P22314
LQEFNNSFVDALGSD	USP37	841	Q86T82
GEANQNDSVAFEDVA	ZNF788P	16	Q6ZQV5
GDFGEVLNSAANASA	TPD52	196	P55327
PDINFNDAFENFALD	MID2	371	Q9UJV3
AAFGDLNSDKQTDLF	ITFG1	51	Q8TB96
EQVLQEDFASANAGS	HIVEP2	1311	P31629
LFGSDVVAQFNAAND	PPP4C	216	P60510
QFGFNDEKFADQDDI	PPP6R3	561	Q5H9R7
TVQVEFAAAEGAAAA	THAP11	191	Q96EK4
NVAYFRFDINDATGD	TRRAP	3706	Q9Y4A5
FINFASFDASDAAIE	SF3B4	146	Q15427
ADARAFFAQDGVQSL	TRPM4	661	Q8TD43
SLAAAQNGFVDSAAA	ZIC2	41	O95409
LNFGSKEDAAQFAAG	VASP	91	P50552
FIQNFVAGDDESRSD	VPS13D	1406	Q5THJ4
FNDSLTFLENAADVG	KEL	626	P23276
LVNAAFSEIQDGAFS	LGI3	71	Q8N145
LDLSGQAFDEAFAEF	MYOM2	1316	P54296
TDRGDAFDFNVSLQD	NECAP1	111	Q8NC96