Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaldose reductase (NADPH) activity

AKR1E2 AKR1C3 AKR1C4

9.64e-0614613GO:0004032
GeneOntologyMolecularFunctionandrosterone dehydrogenase (B-specific) activity

AKR1C3 AKR1C4

5.49e-054612GO:0047042
GeneOntologyMolecularFunctionketoreductase activity

AKR1C3 AKR1C4

5.49e-054612GO:0045703
GeneOntologyMolecularFunctionchlordecone reductase activity

AKR1C3 AKR1C4

5.49e-054612GO:0047743
GeneOntologyMolecularFunctionalcohol dehydrogenase (NADP+) activity

AKR1E2 AKR1C3 AKR1C4

7.53e-0527613GO:0008106
GeneOntologyMolecularFunctiontrans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

AKR1C3 AKR1C4

9.13e-055612GO:0047115
GeneOntologyMolecularFunction15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

AKR1C3 AKR1C4

9.13e-055612GO:0047020
GeneOntologyMolecularFunction17-beta-ketosteroid reductase (NADPH) activity

AKR1C3 AKR1C4

9.13e-055612GO:0072555
GeneOntologyMolecularFunction17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity

AKR1C3 AKR1C4

9.13e-055612GO:0047006
GeneOntologyMolecularFunctionDelta4-3-oxosteroid 5beta-reductase activity

AKR1C3 AKR1C4

9.13e-055612GO:0047787
GeneOntologyMolecularFunctionlithocholic acid binding

AKR1C3 AKR1C4

9.13e-055612GO:1902121
GeneOntologyMolecularFunctionketosteroid monooxygenase activity

AKR1C3 AKR1C4

9.13e-055612GO:0047086
GeneOntologyMolecularFunctionaldo-keto reductase (NADPH) activity

AKR1E2 AKR1C3 AKR1C4

1.26e-0432613GO:0004033
GeneOntologyMolecularFunctiongeranylgeranyl reductase activity

AKR1C3 AKR1C4

1.37e-046612GO:0045550
GeneOntologyMolecularFunction17-beta-hydroxysteroid dehydrogenase (NADP+) activity

AKR1C3 AKR1C4

1.91e-047612GO:0072582
GeneOntologyMolecularFunction5alpha-androstane-3beta,17beta-diol dehydrogenase activity

AKR1C3 AKR1C4

2.54e-048612GO:0047024
GeneOntologyMolecularFunctionandrosterone dehydrogenase activity

AKR1C3 AKR1C4

2.54e-048612GO:0047023
GeneOntologyMolecularFunctionenone reductase activity

AKR1C3 AKR1C4

2.54e-048612GO:0035671
GeneOntologyMolecularFunctionandrostan-3-alpha,17-beta-diol dehydrogenase activity

AKR1C3 AKR1C4

3.26e-049612GO:0047044
GeneOntologyMolecularFunctiontestosterone dehydrogenase (NAD+) activity

AKR1C3 AKR1C4

3.26e-049612GO:0047035
GeneOntologyMolecularFunctionNADP+ binding

AKR1C3 AKR1C4

3.26e-049612GO:0070401
GeneOntologyMolecularFunctiontestosterone 17-beta-dehydrogenase (NADP+) activity

AKR1C3 AKR1C4

4.07e-0410612GO:0047045
GeneOntologyMolecularFunctionbile acid binding

AKR1C3 AKR1C4

4.07e-0410612GO:0032052
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

AKR1C3 ALDH4A1 AKR1C4

4.25e-0448613GO:0016620
GeneOntologyMolecularFunctiontestosterone dehydrogenase [NAD(P)+] activity

AKR1C3 AKR1C4

4.96e-0411612GO:0030283
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors

AKR1C3 ALDH4A1 AKR1C4

6.70e-0456613GO:0016903
GeneOntologyMolecularFunctionretinal dehydrogenase activity

AKR1C3 AKR1C4

8.16e-0414612GO:0001758
GeneOntologyMolecularFunctionGTPase activator activity

GAPVD1 ARHGAP24 RANBP3 ADGRB3 ARAP2

1.61e-03279615GO:0005096
GeneOntologyMolecularFunctionestradiol 17-beta-dehydrogenase [NAD(P)+] activity

AKR1C3 AKR1C4

1.68e-0320612GO:0004303
GeneOntologyMolecularFunctionGTP-dependent protein binding

AP1G1 EEA1

2.43e-0324612GO:0030742
GeneOntologyMolecularFunctionall-trans-retinol dehydrogenase (NAD+) activity

AKR1C3 AKR1C4

2.43e-0324612GO:0004745
GeneOntologyMolecularFunctionalcohol dehydrogenase (NAD+) activity

AKR1C3 AKR1C4

2.85e-0326612GO:0004022
GeneOntologyMolecularFunctionNADPH binding

AKR1C3 AKR1C4

2.85e-0326612GO:0070402
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

SLC26A9 GRIK2 AKR1C4 ABCD2

3.69e-03207614GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

SLC26A9 GRIK2 AKR1C4 ABCD2

3.75e-03208614GO:0005342
GeneOntologyMolecularFunctionalcohol dehydrogenase [NAD(P)+] activity

AKR1C3 AKR1C4

3.78e-0330612GO:0018455
GeneOntologyMolecularFunctionmonocarboxylic acid binding

AKR1C3 AKR1C4 ALB

4.30e-03107613GO:0033293
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

GAPVD1 ARHGAP24 RANBP3 GPS1 ADGRB3 ARAP2

4.44e-03507616GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

GAPVD1 ARHGAP24 RANBP3 GPS1 ADGRB3 ARAP2

4.44e-03507616GO:0030695
GeneOntologyMolecularFunctionsteroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1C3 AKR1C4

4.56e-0333612GO:0033764
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

AKR1C3 AKR1C4

4.84e-0334612GO:0016628
GeneOntologyMolecularFunctioncarboxylic acid binding

SELE AKR1C3 AKR1C4 ALB

6.13e-03239614GO:0031406
GeneOntologyMolecularFunctionsteroid dehydrogenase activity

AKR1C3 AKR1C4

6.33e-0339612GO:0016229
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

AKR1C3 AKR1C4

6.65e-0340612GO:0016709
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1E2 AKR1C3 AKR1C4

6.91e-03127613GO:0016616
GeneOntologyMolecularFunctionorganic acid binding

SELE AKR1C3 AKR1C4 ALB

7.57e-03254614GO:0043177
GeneOntologyMolecularFunctionmolecular adaptor activity

CUL1 SUPT3H ANK3 AP1G1 SURF6 HIPK2 SIN3A NCOA4 ADAM10 FAN1

7.60e-0313566110GO:0060090
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

CUL1 SUPT3H ANK3 AP1G1 SURF6 HIPK2 SIN3A NCOA4 FAN1

8.29e-031160619GO:0030674
GeneOntologyBiologicalProcessresponse to jasmonic acid

AKR1C3 AKR1C4

4.97e-054602GO:0009753
GeneOntologyBiologicalProcessprogesterone catabolic process

AKR1C3 AKR1C4

4.97e-054602GO:0006709
GeneOntologyBiologicalProcesscellular response to jasmonic acid stimulus

AKR1C3 AKR1C4

4.97e-054602GO:0071395
GeneOntologyBiologicalProcessC21-steroid hormone catabolic process

AKR1C3 AKR1C4

4.97e-054602GO:0008208
GeneOntologyBiologicalProcessfarnesol metabolic process

AKR1C3 AKR1C4

8.27e-055602GO:0016487
GeneOntologyBiologicalProcessfarnesol catabolic process

AKR1C3 AKR1C4

8.27e-055602GO:0016488
GeneOntologyBiologicalProcessnegative regulation of isoprenoid metabolic process

AKR1C3 AKR1C4

8.27e-055602GO:0045827
GeneOntologyBiologicalProcesssesquiterpenoid catabolic process

AKR1C3 AKR1C4

8.27e-055602GO:0016107
GeneOntologyBiologicalProcessolefinic compound catabolic process

AKR1C3 AKR1C4

8.27e-055602GO:0120256
GeneOntologyBiologicalProcessnegative regulation of retinoic acid biosynthetic process

AKR1C3 AKR1C4

8.27e-055602GO:1900053
GeneOntologyBiologicalProcesssesquiterpenoid metabolic process

AKR1C3 AKR1C4

1.24e-046602GO:0006714
GeneOntologyBiologicalProcesspolyprenol catabolic process

AKR1C3 AKR1C4

1.24e-046602GO:0016095
GeneOntologyBiologicalProcessresponse to prostaglandin D

AKR1C3 AKR1C4

1.73e-047602GO:0071798
GeneOntologyBiologicalProcesscellular response to prostaglandin D stimulus

AKR1C3 AKR1C4

1.73e-047602GO:0071799
GeneOntologyBiologicalProcessregulation of retinoic acid biosynthetic process

AKR1C3 AKR1C4

1.73e-047602GO:1900052
GeneOntologyBiologicalProcessdaunorubicin metabolic process

AKR1C3 AKR1C4

2.96e-049602GO:0044597
GeneOntologyBiologicalProcessdoxorubicin metabolic process

AKR1C3 AKR1C4

3.69e-0410602GO:0044598
GeneOntologyBiologicalProcessregulation of isoprenoid metabolic process

AKR1C3 AKR1C4

3.69e-0410602GO:0019747
GeneOntologyBiologicalProcessnegative regulation of vitamin metabolic process

AKR1C3 AKR1C4

3.69e-0410602GO:0046137
GeneOntologyBiologicalProcesspolyketide metabolic process

AKR1C3 AKR1C4

3.69e-0410602GO:0030638
GeneOntologyBiologicalProcessaminoglycoside antibiotic metabolic process

AKR1C3 AKR1C4

3.69e-0410602GO:0030647
GeneOntologyBiologicalProcessregulation of testosterone biosynthetic process

AKR1C3 AKR1C4

4.50e-0411602GO:2000224
GeneOntologyBiologicalProcessterpenoid catabolic process

AKR1C3 AKR1C4

4.50e-0411602GO:0016115
GeneOntologyBiologicalProcessprotein monoubiquitination

CUL1 FANCM OBI1

5.22e-0454603GO:0006513
GeneOntologyBiologicalProcessretinoic acid biosynthetic process

AKR1C3 AKR1C4

7.40e-0414602GO:0002138
GeneOntologyBiologicalProcessisoprenoid catabolic process

AKR1C3 AKR1C4

7.40e-0414602GO:0008300
DomainALDOKETO_REDUCTASE_1

AKR1E2 AKR1C3 AKR1C4

3.72e-0610603PS00798
DomainAldo/ket_reductase_CS

AKR1E2 AKR1C3 AKR1C4

3.72e-0610603IPR018170
DomainAldo/keto_reductase

AKR1E2 AKR1C3 AKR1C4

3.72e-0610603IPR020471
DomainALDOKETO_REDUCTASE_2

AKR1E2 AKR1C3 AKR1C4

3.72e-0610603PS00062
DomainALDOKETO_REDUCTASE_3

AKR1E2 AKR1C3 AKR1C4

3.72e-0610603PS00063
Domain-

AKR1E2 AKR1C3 AKR1C4

1.71e-05166033.20.20.100
DomainNADP_OxRdtase_dom

AKR1E2 AKR1C3 AKR1C4

2.08e-0517603IPR023210
DomainAldo_ket_red

AKR1E2 AKR1C3 AKR1C4

2.08e-0517603PF00248
DomainAldo/ket_red/Kv-b

AKR1E2 AKR1C3 AKR1C4

2.08e-0517603IPR001395
DomainZINC_FINGER_C2H2_2

RLF ZNF462 SCRT2 ZC3H7A ZNF800 ZNF296 EEA1 ZNF879 ZNF441

7.71e-04775609PS50157
DomainZINC_FINGER_C2H2_1

RLF ZNF462 SCRT2 ZC3H7A ZNF800 ZNF296 EEA1 ZNF879 ZNF441

7.85e-04777609PS00028
DomainZnf_C2H2-like

RLF ZNF462 SCRT2 ZC3H7A ZNF800 ZNF296 EEA1 ZNF879 ZNF441

9.32e-04796609IPR015880
DomainZnf_C2H2

RLF ZNF462 SCRT2 ZC3H7A ZNF800 ZNF296 EEA1 ZNF879 ZNF441

1.01e-03805609IPR007087
DomainZnF_C2H2

RLF ZNF462 SCRT2 ZC3H7A ZNF800 ZNF296 EEA1 ZNF879 ZNF441

1.04e-03808609SM00355
DomainZZ

DTNA ZSWIM2

1.50e-0318602PF00569
DomainZF_ZZ_2

DTNA ZSWIM2

1.50e-0318602PS50135
DomainZF_ZZ_1

DTNA ZSWIM2

1.50e-0318602PS01357
DomainZnf_ZZ

DTNA ZSWIM2

1.68e-0319602IPR000433
DomainZnF_ZZ

DTNA ZSWIM2

1.68e-0319602SM00291
DomainRho_GTPase_activation_prot

GAPVD1 ARHGAP24 ARAP2

2.85e-0388603IPR008936
Domain-

ZC3H7A SPAG1 SPATA16 GPS1

4.40e-032076041.25.40.10
Domain-

RLF ZNF462 SCRT2 ZNF800 ZNF296 ZNF879 ZNF441

5.91e-036796073.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

RLF ZNF462 SCRT2 ZNF800 ZNF296 ZNF879 ZNF441

6.64e-03694607IPR013087
DomainTPR-like_helical_dom

ZC3H7A SPAG1 SPATA16 GPS1

6.67e-03233604IPR011990
PathwayREACTOME_PREDNISONE_ADME

AKR1C3 AKR1C4 ALB

5.50e-0523463MM16639
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2

HIPK2 SIN3A

1.04e-045462MM15582
PathwayWP_BENZOAPYRENE_METABOLISM

AKR1C3 AKR1C4

3.70e-049462M39344
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_KEAP1_NRF2_SIGNALIG_PATHWAY

AKR1C3 AKR1C4

3.70e-049462M47817
PathwayREACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM

AKR1C3 AKR1C4 ALB

3.92e-0444463M499
PathwayREACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM

AKR1C3 AKR1C4 ALB

4.19e-0445463MM14751
PathwayKEGG_MEDICUS_ENV_FACTOR_BENZO_A_PYRENRE_TO_CYP_MEDIATED_METABOLISM

AKR1C3 AKR1C4

5.62e-0411462M47812
PathwayREACTOME_METABOLISM_OF_STEROIDS

SREBF2 AKR1C3 AKR1C4 ALB

7.43e-04126464MM15553
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL

AKR1C3 AKR1C4

7.94e-0413462M17842
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL

AKR1C3 AKR1C4

7.94e-0413462MM14747
PathwayWP_GLUCOCORTICOID_BIOSYNTHESIS

AKR1C3 AKR1C4

9.25e-0414462M46449
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL

AKR1C3 AKR1C4

9.25e-0414462M27074
PathwayWP_MINERALOCORTICOID_BIOSYNTHESIS

AKR1C3 AKR1C4

9.25e-0414462M46453
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL

AKR1C3 AKR1C4

9.25e-0414462MM14748
PathwayREACTOME_SYNTHESIS_OF_PROSTAGLANDINS_PG_AND_THROMBOXANES_TX

AKR1C3 AKR1C4

1.06e-0315462MM14870
Pubmed

A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13.

AKR1E2 AKR1C3 AKR1C4

1.88e-07762312562828
Pubmed

Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases.

AKR1C3 AKR1C4

3.13e-0626227650035
Pubmed

Neutrophils Turn Plasma Proteins into Weapons against HIV-1.

SERPINC1 ALB

3.13e-06262223840401
Pubmed

Affinity, kinetics, and thermodynamics of E-selectin binding to E-selectin ligand-1.

SELE GLG1

3.13e-06262211404363
Pubmed

A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing.

AKR1C3 AKR1C4 OBI1

6.02e-062062323636947
Pubmed

Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans.

AKR1C3 AKR1C4

9.37e-0636227626489
Pubmed

Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition.

AKR1C3 AKR1C4 ABCD2

1.21e-052562326098214
Pubmed

Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.

AKR1C3 AKR1C4

1.87e-05462220124700
Pubmed

Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).

AKR1C3 AKR1C4

1.87e-05462210500239
Pubmed

Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.

AKR1C3 AKR1C4

1.87e-05462216508162
Pubmed

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.

AKR1C3 AKR1C4

1.87e-05462219487289
Pubmed

Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C3 AKR1C4

1.87e-05462214967952
Pubmed

Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.

AKR1C3 AKR1C4

1.87e-05462210393440
Pubmed

Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.

AKR1C3 AKR1C4

1.87e-05462215193432
Pubmed

Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.

AKR1C3 AKR1C4

1.87e-05462231479646
Pubmed

Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44.

SELE GLG1

1.87e-05462217442598
Pubmed

Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C3 AKR1C4

1.87e-05462215222881
Pubmed

Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.

AKR1C3 AKR1C4

1.87e-05462216191478
Pubmed

Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.

AKR1C3 AKR1C4

1.87e-05462215577209
Pubmed

Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.

AKR1C3 AKR1C4

1.87e-05462210702227
Pubmed

Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.

AKR1C3 AKR1C4

1.87e-05462217034817
Pubmed

Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.

AKR1C3 AKR1C4

1.87e-05462217629694
Pubmed

RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.

AKR1C3 AKR1C4

1.87e-05462229764944
Pubmed

Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.

AKR1C3 AKR1C4

1.87e-05462210526179
Pubmed

Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.

AKR1C3 AKR1C4

1.87e-05462217888864
Pubmed

Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.

AKR1C3 AKR1C4

1.87e-05462217442338
Pubmed

Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.

AKR1C3 AKR1C4

1.87e-05462228329705
Pubmed

Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.

AKR1C3 AKR1C4

1.87e-05462216018803
Pubmed

Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C3 AKR1C4

1.87e-05462217272929
Pubmed

Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.

AKR1C3 AKR1C4

1.87e-05462219237748
Pubmed

Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.

AKR1C3 AKR1C4

1.87e-05462218667791
Pubmed

Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.

AKR1C3 AKR1C4

1.87e-05462228259989
Pubmed

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.

AKR1C3 AKR1C4

1.87e-05462221521174
Pubmed

Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

AKR1C3 AKR1C4

1.87e-0546228274401
Pubmed

Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.

AKR1C3 AKR1C4

1.87e-05462216511129
Pubmed

Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase.

AKR1C3 AKR1C4

1.87e-05462210803568
Pubmed

AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.

AKR1C3 AKR1C4

1.87e-05462234590152
Pubmed

Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.

AKR1C3 AKR1C4

1.87e-0546227789999
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

GAPVD1 ANK3 AP1G1 GLG1 SREBF2 MASTL HIPK2 AKR1C3 AKR1C4 NCOA4

2.05e-051084621011544199
Pubmed

A High-Density Map for Navigating the Human Polycomb Complexome.

RLF ZNF462 CUL1 SETD1B ZNF296 SURF6 SIN3A

2.84e-0549562727705803
Pubmed

Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family.

AKR1C3 AKR1C4

3.12e-0556227737980
Pubmed

Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation.

AP1G1 EEA1

3.12e-05562212536145
Pubmed

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.

AKR1C3 AKR1C4

3.12e-05562221851338
Pubmed

Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow.

SELE GLG1

3.12e-05562222021370
Pubmed

Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome.

CUL1 GPS1

3.12e-05562223408908
Pubmed

Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.

AKR1C3 AKR1C4

3.12e-05562217872381
Pubmed

Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity.

AKR1C3 AKR1C4

3.12e-05562217064890
Pubmed

Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.

AKR1C3 AKR1C4

3.12e-05562210672042
Pubmed

Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F2α (PGF2α) levels.

AKR1C3 AKR1C4

3.12e-05562238788959
Pubmed

Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.

AKR1C3 AKR1C4

3.12e-05562216984997
Pubmed

Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice.

AKR1C3 AKR1C4

3.12e-05562218003893
Pubmed

An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.

HIPK2 AKR1C3 AKR1C4

4.01e-053762321362171
Pubmed

Identification of 10 murine homeobox genes.

SELE SERPINC1 ALB

4.35e-05386231683707
Pubmed

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand.

SELE SERPINC1

4.67e-0566227511063
Pubmed

The Gαq/11-provoked induction of Akr1c18 in murine luteal cells is mediated by phospholipase C.

AKR1C3 AKR1C4

4.67e-05662229107092
Pubmed

Multiple functions of Jab1 are required for early embryonic development and growth potential in mice.

CUL1 GPS1

4.67e-05662215299027
Pubmed

Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues.

AKR1C3 AKR1C4

4.67e-05662219273550
Pubmed

Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.

AKR1C3 AKR1C4

4.67e-05662215860270
Pubmed

Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase.

AKR1C3 AKR1C4

4.67e-05662215471942
Pubmed

Lymphotactin: a cytokine that represents a new class of chemokine.

SELE SERPINC1

4.67e-0566227973732
Pubmed

MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells.

AKR1C3 AKR1C4

4.67e-05662226748576
Pubmed

Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone.

AKR1C3 AKR1C4

4.67e-05662217122075
Pubmed

Decidual prolactin silences the expression of genes detrimental to pregnancy.

AKR1C3 AKR1C4

4.67e-05662217255200
Pubmed

The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation.

CUL1 GPS1

6.53e-05762221169563
Pubmed

The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells.

AKR1C3 AKR1C4

6.53e-05762226160177
Pubmed

Aldo-ketoreductase 1c19 ablation does not affect insulin secretion in murine islets.

AKR1C3 AKR1C4

6.53e-05762234843575
Pubmed

MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor.

AKR1C3 AKR1C4

6.53e-05762222529366
Pubmed

A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional but reduced Pde11a: Phenotype and impact on adrenocortical function.

AKR1C3 AKR1C4

6.53e-05762233127481
Pubmed

PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation.

CUL1 HIPK2

6.53e-05762218809579
Pubmed

Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1.

SELE SERPINC1

6.53e-0576221694218
Pubmed

17Beta-HSD type 5 expression and the emergence of differentiated epithelial Type II cells in fetal lung: a novel role for androgen during the surge of surfactant.

AKR1C3 AKR1C4

6.53e-05762216337335
Pubmed

Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.

SREBF2 AKR1C3 AKR1C4

8.27e-054762311208732
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

CUL1 ZC3H7A SETD1B DTNA HIPK2 ZDBF2 OBI1

8.38e-0558862738580884
Pubmed

FBW7 suppresses cell proliferation and G2/M cell cycle transition via promoting γ-catenin K63-linked ubiquitylation.

CUL1 ALB

8.69e-05862229408378
Pubmed

Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity.

AKR1C3 AKR1C4

8.69e-05862233584538
Pubmed

Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells.

GAPVD1 EEA1

8.69e-05862219725050
Pubmed

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin.

AKR1C3 AKR1C4

8.69e-05862220837989
Pubmed

Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues.

AKR1C3 AKR1C4

8.69e-0586229224647
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

CUL1 ANK3 AP1G1 GLG1 MASTL AKR1C3 EEA1 HYDIN

9.08e-0580762830575818
Pubmed

Electron microscopy and in vitro deneddylation reveal similar architectures and biochemistry of isolated human and Flag-mouse COP9 signalosome complexes.

CUL1 GPS1

1.12e-04962224973710
Pubmed

Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models.

AKR1C3 AKR1C4

1.12e-04962233348080
Pubmed

The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun.

CUL1 SIN3A

1.12e-04962217704768
Pubmed

Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.

AKR1C3 AKR1C4 ALB

1.12e-045262323260145
Pubmed

Lack of placental neurosteroid alters cortical development and female somatosensory function.

AKR1C3 AKR1C4

1.39e-041062236313771
Pubmed

Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation.

CUL1 HIPK2

1.39e-041062218765672
Pubmed

Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function.

CUL1 GPS1

1.39e-041062226976604
Pubmed

Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality.

CUL1 GPS1

1.39e-041062219141280
Pubmed

The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain.

CUL1 GPS1

1.39e-041062222956996
Pubmed

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.

CUL1 ARHGAP24 AP1G1 GPS1 ALB ZNF879

1.53e-0445162636168627
Pubmed

Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin.

ANK3 DTNA

1.70e-041162210995443
Pubmed

Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3.

CUL1 GPS1

2.04e-041262220399188
Pubmed

Endogenous biotin as a marker of adrenocortical cells with steroidogenic potential.

AKR1C3 AKR1C4

2.04e-041262221256921
Pubmed

Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.

AKR1C3 AKR1C4

2.04e-041262228893949
Pubmed

A Novel Population of Inner Cortical Cells in the Adrenal Gland That Displays Sexually Dimorphic Expression of Thyroid Hormone Receptor-β1.

AKR1C3 AKR1C4

2.04e-041262225774556
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

SPAG1 KCNT2 GLG1 AKR1C3 ZSWIM2 ADAM10 HYDIN

2.16e-0468662729987050
Pubmed

Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.

GAPVD1 ANK3 MASTL FAN1

2.30e-0416762425659891
Pubmed

The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.

AKR1C3 AKR1C4

2.41e-041362211682476
Pubmed

S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer.

CUL1 SIN3A

2.41e-041362229507620
Pubmed

Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice.

AKR1C3 AKR1C4

2.41e-041362217062636
Pubmed

A link between lung androgen metabolism and the emergence of mature epithelial type II cells.

AKR1C3 AKR1C4

2.41e-041362215117747
CytobandEnsembl 112 genes in cytogenetic band chr10p15

AKR1E2 IDI2-AS1 AKR1C3 AKR1C4

7.06e-0690624chr10p15
Cytoband10p15.1

AKR1E2 AKR1C4

6.63e-042862210p15.1
GeneFamilyAldo-keto reductases

AKR1E2 AKR1C3 AKR1C4

6.86e-0615463399
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

DTNA ZSWIM2

9.44e-041846291
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

RLF ZNF462 SCRT2 ZNF800 ZNF296 ZNF879 ZNF441

2.10e-0371846728
CoexpressionAtlasFacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_2500_k-means-cluster#2

ZNF462 ZNF800 IFRD1 SETD1B DTNA MASTL GRIK2 ZDBF2

1.66e-05395618Facebase_RNAseq_e8.5_Floor Plate_2500_K2
ToppCellE12.5-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SPAG1 SYCP2 GRIK2 NCOA4 ZNF879

1.69e-06143625cc396b81a5e47d78c2d1cb49d682391376b63476
ToppCellLA-16._Neuronal|LA / Chamber and Cluster_Paper

ANK3 ADGRB3 GRIK2 CXorf66 ARAP2

3.73e-06168625c55bbfbde8bb954f1cb9af82007bdd1f8070fee3
ToppCellCOVID-19-Heart-Neuronal|Heart / Disease (COVID-19 only), tissue and cell type

ARHGAP24 ANK3 ADGRB3 GRIK2 ARAP2

4.30e-061736256fb5f9e6536a5d57fd8e6657b494047a2d0bc9c7
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK3 ART4 DTNA MACROD2 GRIK2

6.28e-0618762516e55d802fc4e71878305e61ad03806aabd59537
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

RLF IFRD1 AP1G1 CEP85L ARAP2

6.44e-06188625ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellCOPD-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

SPAG1 ANK3 HYDIN PHLDB2 ARAP2

6.44e-06188625186fe1ea328c942910190a4240262c0d8642ea3b
ToppCellfacs-Aorta-Heart-3m|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GLG1 HIPK2 ALB HYDIN ARAP2

7.14e-061926251ccc47792edf9ee23501c8e2165d11271636b66a
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNT2 DTNA GRIK2 HYDIN

7.32e-05160624c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNT2 DTNA GRIK2 HYDIN

7.32e-0516062425c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellLV-16._Neuronal|World / Chamber and Cluster_Paper

ANK3 ADGRB3 GRIK2 ARAP2

8.24e-051656246ed52cb756d21addf46c7f6c457458b01339fe04
ToppCellLA-16._Neuronal|World / Chamber and Cluster_Paper

ANK3 ADGRB3 GRIK2 ARAP2

8.84e-051686242fd1fd2a16ac1c5eb028f93cc3a2477c7747693e
ToppCellCOVID-19-Heart-Neuronal|COVID-19 / Disease (COVID-19 only), tissue and cell type

ARHGAP24 ANK3 ADGRB3 GRIK2

8.84e-0516862488c2c574f428c2502b5fe099bd73b0758f668ef6
ToppCellLV-16._Neuronal|LV / Chamber and Cluster_Paper

ANK3 ADGRB3 GRIK2 ARAP2

9.04e-05169624a8fc8ab0f0757e939e213efb61c03cfe390bf7d2
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP24 PKP3 SERPINC1 PDCD1LG2

1.01e-041746249f7b983459d47b12a1b64e17e29b85a6ff4dc258
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP24 PKP3 SERPINC1 PDCD1LG2

1.01e-04174624ba909e8789a62968e90bc1c4ab614de738c130f7
ToppCellCOVID-19-kidney-PCT-S3-2|kidney / Disease (COVID-19 only), tissue and cell type

KCNT2 SERPINC1 AKR1C4 ALB

1.01e-041746245aa2fb631505600f37d2b87b02def7be139dc262
ToppCellfacs-Marrow-B-cells-24m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNT2 ADGRB3 GRIK2 HYDIN

1.03e-04175624887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCell356C-Lymphocytic-NK_cells-NK_cell_A2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

AKR1E2 ARHGAP24 ART4 MACROD2

1.06e-04176624052b54c4337ca728974a106b6dbd3b72dd28eb23
ToppCellCOVID-19-kidney-PCT-S3-2|COVID-19 / Disease (COVID-19 only), tissue and cell type

KCNT2 SERPINC1 AKR1C4 ALB

1.06e-04176624b6497324e3e52f514ce556a3fa0c3011c45dcc7b
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SELE SPAG1 SLC26A9 ZSWIM2

1.08e-0417762476f5df101c693e5fa61554244d877fc8169ee66f
ToppCellChildren_(3_yrs)-Epithelial-basal_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

FRMPD4 ANK3 MACROD2 GRIK2

1.10e-04178624fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCellRA-16._Neuronal|RA / Chamber and Cluster_Paper

ANK3 ADGRB3 GRIK2 ARAP2

1.15e-041806245842febfdabac61ce970254fb0ef17a628f1b8c0
ToppCellRA-16._Neuronal|World / Chamber and Cluster_Paper

ANK3 ADGRB3 GRIK2 ARAP2

1.18e-041816247d22a43f887e0747f0cb87ba364ff27905ee6eec
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ARHGAP24 KCNT2 ADGRB3 HIPK2

1.20e-04182624ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SELE ART4 SLC26A9 PDCD1LG2

1.20e-04182624f231e86524b628e6e11ac33d5c34be99d454a92a
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D122|Adult / Lineage, Cell type, age group and donor

KCNT2 DTNA PHLDB2 ARAP2

1.25e-04184624561592edc3083fad41b91811151b442207c65dd9
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ZNF462 ANK3 DTNA HYDIN

1.31e-04186624b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ART4 SERPINC1 AKR1C4 ALB

1.34e-04187624edb0ab0154542b1c0b3a2c216c4a60f0f06290b3
ToppCelldroplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ANK3 DTNA ADGRB3 GRIK2

1.36e-04188624502045a39ffb1e92bd9499848368e8fa971edb88
ToppCellChildren_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

AKR1E2 DTNA HIPK2 AKR1C3

1.36e-04188624d7a9fb5b021e127b8d927658a55a71098d513b5c
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-erythrocytic|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ART4 SERPINC1 AKR1C4 ALB

1.39e-041896247899af78b273d9c7f029d52f7e0cf6df4da41f5e
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ART4 SERPINC1 AKR1C4 ALB

1.42e-04190624a34293601aefe5fb5c400c14091294b9ddaa195b
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

ARHGAP24 KCNT2 ANK3 ADGRB3

1.45e-0419162478c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCellCOVID-19-lung-CD4+_Treg|COVID-19 / Disease (COVID-19 only), tissue and cell type

ANK3 CEP85L ABCD2 ARAP2

1.45e-041916245a4ad5ae5c2dbfb225158cb598ef649c26a48350
ToppCellCOVID-19-T_cells-CD4+_T_cells|COVID-19 / group, cell type (main and fine annotations)

ANK3 CEP85L ABCD2 ARAP2

1.45e-041916240646cca78e24aeb6baa9934d3c439b797c567997
ToppCell367C-Myeloid-Dendritic-cDC_activated|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

ZC3H7A ZNF296 ARAP2 PDCD1LG2

1.48e-04192624e44e37e5aeba8628556020d05e1606b28e2faa4f
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

IFRD1 ANK3 AP1G1 ARAP2

1.48e-0419262447646d7e4990be85072987f92bf18d52f8da752e
ToppCellCOPD-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

ARHGAP24 DTNA MACROD2 ADGRB3

1.48e-0419262462904f94dfce430456f05066522cbf9bd29f4d7e
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Proximal_secretory_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

GAPVD1 SETD1B PKP3 ALB

1.51e-041936240ef076417ffe2dd1cbc2c3d1e35c7f8522af143b
ToppCellsevere-B_cell|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ARHGAP24 MACROD2 ZDBF2 FANCM

1.54e-041946242fee6083fb56b16d1f04fd0b92ec622fd26ba3fa
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ANK3 MACROD2 SREBF2 GRIK2

1.57e-04195624dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

SUPT3H ARHGAP24 ANK3 MACROD2

1.60e-04196624ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FRMPD4 MACROD2 ADGRB3 GRIK2

1.60e-04196624676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCelldroplet-Kidney-nan-3m-Epithelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP24 ANK3 ALDH4A1 PHLDB2

1.60e-041966249f39cb3de886283da34ee7511a92d94930a6c851
ToppCellmLN-T_cell-Treg|T_cell / Region, Cell class and subclass

ZC3H7A ARHGAP24 AKR1C3 ADAM10

1.63e-041976243779489d57ebda33277c79cba037f4c73128c8ba
ToppCellCOVID-19-Fibroblasts|COVID-19 / group, cell type (main and fine annotations)

KCNT2 DTNA ADGRB3 PHLDB2

1.63e-04197624fb847f2277609c31fffcdf49517243ce0684facf
ToppCellSevere-B_intermediate-10|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ARHGAP24 ANK3 MACROD2 EEA1

1.66e-04198624dfae26c3513a82bb7cb8dadbfcea2a1f420b1bab
ToppCellfacs-Tongue-nan-3m-Epithelial|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GLG1 NCOA4 ADAM10 ARAP2

1.66e-041986242f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCell(11)_FOXN4+-(2)_GFP_FOXI1|(11)_FOXN4+ / shred by cell type by condition

CUL1 ZNF800 HIPK2 AKR1C3

1.66e-0419862476d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCellfacs-Tongue-nan-3m|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GLG1 NCOA4 ADAM10 ARAP2

1.66e-04198624f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCellbackground-Hepatic_Stellate_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

ANK3 ADGRB3 SERPINC1 ALB

1.66e-0419862479f32f965aed6a10c5cb803173e3db7b32e07a91
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ZNF462 AKR1E2 IDI2-AS1 HYDIN

1.69e-0419962419a97e27a4758e794ce7246d295e112b47931a48
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ANK3 MACROD2 SREBF2 SLC26A9

1.69e-041996242dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCellmLN-Dendritic_cell-Lymphoid_DC|Dendritic_cell / Region, Cell class and subclass

ZC3H7A SETD1B HIPK2 ARAP2

1.73e-042006243813fa1ee1462ba83fd8b6253070f46f0b063084
DrugDorzolamide hydrochloride [130693-82-2]; Down 200; 11uM; MCF7; HT_HG-U133A

SUPT3H SYCP2 RANBP3 SREBF2 EEA1 ADAM10 OBI1

1.11e-061986276259_DN
DiseaseFetal Cerebral Ventriculomegaly

SIN3A HYDIN

8.77e-057612C2936718
DiseaseCerebral ventriculomegaly

SIN3A HYDIN

8.77e-057612C1531647
DiseaseHydrocephalus Ex-Vacuo

SIN3A HYDIN

8.77e-057612C0270720
DiseasePost-Traumatic Hydrocephalus

SIN3A HYDIN

8.77e-057612C0477432
DiseaseCommunicating Hydrocephalus

SIN3A HYDIN

8.77e-057612C0009451
DiseaseObstructive Hydrocephalus

SIN3A HYDIN

8.77e-057612C0549423
DiseaseAqueductal Stenosis

SIN3A HYDIN

1.17e-048612C2936786
DiseaseCongenital Hydrocephalus

SIN3A HYDIN

1.17e-048612C0020256
DiseaseFanconi anemia (implicated_via_orthology)

FANCM FAN1

1.17e-048612DOID:13636 (implicated_via_orthology)
DiseaseHydrocephalus

SIN3A HYDIN

1.50e-049612C0020255
DiseaseRespiratory Distress Syndrome, Adult

IFRD1 SERPINC1 ALB

2.04e-0455613C0035222
Diseaseamyotrophic lateral sclerosis, age at onset

IFRD1 ARAP2

4.34e-0415612EFO_0004847, MONDO_0004976
DiseaseManic Disorder

ANK3 GRIK2 AKR1C4

4.35e-0471613C0024713
DiseaseTNF-related apoptosis-inducing ligand measurement

DTNA SPATA16 MACROD2

4.53e-0472613EFO_0008300
DiseaseUrticaria

SELE ALB

4.95e-0416612C0042109
DiseaseManic

ANK3 GRIK2 AKR1C4

5.73e-0478613C0338831
DiseaseDepression, Bipolar

ANK3 GRIK2 AKR1C4

5.94e-0479613C0005587
Diseasephysical activity

OR6B1 SETD1B ARAP2

8.14e-0488613EFO_0003940
DiseaseNephritis, Interstitial

ALB FAN1

1.13e-0324612C0027707
DiseaseLiver Failure, Acute

SERPINC1 ALB

1.13e-0324612C0162557
DiseaseBell's palsy

SUPT3H ART4 GRIK2

1.25e-03102613EFO_0007167
DiseaseNephrotic Syndrome

SERPINC1 ALB

1.43e-0327612C0027726
DiseaseDrug-Induced Stevens Johnson Syndrome

CUL1 ALB

1.65e-0329612C1274933
DiseaseToxic Epidermal Necrolysis

CUL1 ALB

1.65e-0329612C0014518
DiseaseThrombocytopenia

MASTL ALB

1.65e-0329612C0040034
DiseaseMycoplasma-Induced Stevens-Johnson Syndrome

CUL1 ALB

1.65e-0329612C3658301
DiseaseStevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum

CUL1 ALB

1.65e-0329612C3658302
DiseaseStevens-Johnson Syndrome

CUL1 ALB

1.76e-0330612C0038325
DiseaseNEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE

GAPVD1 ARHGAP24

1.76e-0330612C1868672
Diseaseblood nickel measurement

SCRT2 MACROD2 PHLDB2

1.99e-03120613EFO_0007583

Protein segments in the cluster

PeptideGeneStartEntry
LKRYSLNEFCALKKN

USP26

521

Q9BXU7
YLNQSKLLDFCKSKD

AKR1C4

196

P17516
SSAKQRLKCASLQKF

ALB

216

P02768
LCKLDYACKLASSDK

CXorf66

191

Q5JRM2
KRAACLVAAAYALKT

ABCD2

21

Q9UBJ2
LKFSKKDLSCSNFSL

ADGRB3

71

O60242
YFNRSKLLDFCKSKD

AKR1C3

196

P42330
KKRTTSAEKNTCQLY

ADAM10

211

O14672
EKNSKRDYLSSSFLC

MASTL

541

Q96GX5
VAKFCYADKSLLNKA

ALDH4A1

91

P30038
CFQSLRRKNSKASKS

ARAP2

421

Q8WZ64
AKLNCRLYRKANKSS

SERPINC1

156

P01008
ESAAAYTKATARKCL

RANBP3

371

Q9H6Z4
QLCQKLYSSKDTTKR

PDCD1LG2

246

Q9BQ51
LKTSNSYLRKKAALC

AP1G1

146

O43747
SLLDTYQKCGLKRKS

HIPK2

121

Q9H2X6
KKTKDYVQDRSCNLA

ASB17

116

Q8WXJ9
TDDCFANSKKYKTRR

FANCM

1631

Q8IYD8
SYRDAKKKLRLALCS

GAPVD1

1116

Q14C86
RKYKQAAKCLLLASF

GPS1

261

Q13098
TSKADLNCSKNKDLY

OBI1

331

Q5W0B1
SKKKLALCYTAACTN

SELE

131

P16581
RAKDCYSLALSKLEK

KCNT2

851

Q6UVM3
LLKSEKSSYQKCNSH

NCOA4

261

Q13772
AKYEDFLSCAKLLSK

ARHGAP24

226

Q8N264
LKDECKKLQSQYASS

EEA1

251

Q15075
SLAKSCKSDLKKYRC

GLG1

371

Q92896
LLCGKSRDKYKSSLF

HYDIN

2831

Q4G0P3
LLARYCDSLLKKSSK

CUL1

421

Q13616
YSCTSKRKSKLADGE

FRMPD4

1021

Q14CM0
SANRKCLHKSLYKKD

IDI2-AS1

161

Q9NZ38
KKKSDANASYLRAAR

ANK3

36

Q12955
KRSSTLDCKYKFESC

CEP85L

221

Q5SZL2
NSAAFKARTKARSKC

IFRD1

426

O00458
AKKLTNALSKSLSCA

DTNA

296

Q9Y4J8
SKKNAQLEKRSFCSA

GRIK2

846

Q13002
SHKEDLANCYKSSLK

MACROD2

156

A1Z1Q3
CLGSLASKLSRKYVK

FAN1

151

Q9Y2M0
RQCDKSFALKSYLHK

SCRT2

271

Q9NQ03
KLRNAFRCSSAKIKA

SLC26A9

36

Q7LBE3
SLDKLECRFKLNSYK

SIN3A

1161

Q96ST3
DKKDKLRYLNSSRAS

SETD1B

1756

Q9UPS6
KDASSCYRQKKYALA

SPATA16

181

Q9BXB7
AKDAYLQSLAKKICS

SURF6

6

O75683
KENLCNLEKKYSSLS

PHLDB2

801

Q86SQ0
KEALKKLAYCQASRS

OR6B1

296

O95007
ETACRKSLKALKLNY

AKR1E2

81

Q96JD6
KCYSDAAAKKQARSL

PKP3

346

Q9Y446
KKLYDCKECASFSSL

ZNF441

166

Q8N8Z8
CESRQLSFSKKASKF

SUPT3H

186

O75486
YKECNKRFLCSKALA

RLF

1366

Q13129
TKKNYKDLSNSESEC

SYCP2

1021

Q9BX26
DALSKYSECLKINNK

SPAG1

641

Q07617
SVKSAAKESLYCAQR

SREBF2

776

Q12772
KNNKSYVSKISSDCD

ZDBF2

441

Q9HCK1
CSIKLDNSNSKKLTY

ZSWIM2

471

Q8NEG5
LSLNASNCKALYRKS

ZC3H7A

116

Q8IWR0
SNCKALYRKSKALSD

ZC3H7A

121

Q8IWR0
LYKCKECRKAFSQSS

ZNF879

231

B4DU55
CKLCSFKSSYNSRLK

ZNF462

2056

Q96JM2
QKSSSKAEYNLTACK

ZNF800

346

Q2TB10
YACAQSSKLNRHKKT

ZNF296

266

Q8WUU4
STYNCQLLKASSKKC

ART4

276

Q93070