Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	1-phosphatidylinositol-4-phosphate 5-kinase activity	PIP5K1A PIP5K1B PIPSL PIP5K1C	4.50e-10	9	29	4	GO:0016308
GeneOntologyMolecularFunction	phosphatidylinositol kinase activity	PIP5K1A PIP5K1B PIPSL PIP5K1C	5.25e-08	26	29	4	GO:0052742
GeneOntologyMolecularFunction	lipid kinase activity	PIP5K1A PIP5K1B PIPSL PIP5K1C	3.50e-07	41	29	4	GO:0001727
GeneOntologyMolecularFunction	glucan 1,4-alpha-glucosidase activity	MGAM MGAM2	2.04e-06	2	29	2	GO:0004339
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH10 DNAH1 DNAH11	2.21e-06	18	29	3	GO:0008569
GeneOntologyMolecularFunction	1-phosphatidylinositol-3-phosphate 5-kinase activity	PIP5K1A PIP5K1B	6.10e-06	3	29	2	GO:0000285
GeneOntologyMolecularFunction	1-phosphatidylinositol-5-kinase activity	PIP5K1A PIP5K1B	6.10e-06	3	29	2	GO:0052810
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH10 DNAH1 DNAH11	8.80e-06	28	29	3	GO:0051959
GeneOntologyMolecularFunction	alpha-1,4-glucosidase activity	MGAM MGAM2	2.03e-05	5	29	2	GO:0004558
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNAH10 DNAH1 DNAH11	2.07e-05	37	29	3	GO:0045505
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	PIP5K1A PIP5K1B LATS1 PIPSL ART3 PIP5K1C POLR2B SGK3	4.09e-05	938	29	8	GO:0016772
GeneOntologyMolecularFunction	alpha-glucosidase activity	MGAM MGAM2	4.26e-05	7	29	2	GO:0090599
GeneOntologyMolecularFunction	microtubule motor activity	DNAH10 DNAH1 DNAH11	1.41e-04	70	29	3	GO:0003777
GeneOntologyMolecularFunction	glucosidase activity	MGAM MGAM2	2.11e-04	15	29	2	GO:0015926
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	PIP5K1A PIP5K1B LATS1 PIPSL PIP5K1C SGK3	4.63e-04	709	29	6	GO:0016773
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNAH10 DNAH1 DNAH11	6.57e-04	118	29	3	GO:0003774
GeneOntologyMolecularFunction	kinase activity	PIP5K1A PIP5K1B LATS1 PIPSL PIP5K1C SGK3	6.87e-04	764	29	6	GO:0016301
GeneOntologyMolecularFunction	calcium channel regulator activity	GRM2 SGK3	2.78e-03	54	29	2	GO:0005246
GeneOntologyBiologicalProcess	phosphatidylinositol phosphate biosynthetic process	PIP5K1A PIP5K1B PIPSL PIP5K1C	2.14e-06	66	29	4	GO:0046854
GeneOntologyBiologicalProcess	glycerophospholipid biosynthetic process	PIP5K1A PIP5K1B PIPSL PIP5K1C AGPAT2	1.19e-05	217	29	5	GO:0046474
GeneOntologyBiologicalProcess	regulation of Rab protein signal transduction	DENND4A DENND4B	2.85e-05	6	29	2	GO:0032483
GeneOntologyBiologicalProcess	phospholipid biosynthetic process	PIP5K1A PIP5K1B PIPSL PIP5K1C AGPAT2	3.28e-05	268	29	5	GO:0008654
GeneOntologyBiologicalProcess	glycerolipid biosynthetic process	PIP5K1A PIP5K1B PIPSL PIP5K1C AGPAT2	3.28e-05	268	29	5	GO:0045017
GeneOntologyBiologicalProcess	phosphatidylinositol biosynthetic process	PIP5K1A PIP5K1B PIPSL PIP5K1C	3.36e-05	132	29	4	GO:0006661
GeneOntologyBiologicalProcess	glycerophospholipid metabolic process	PIP5K1A PIP5K1B PIPSL PIP5K1C AGPAT2	7.62e-05	320	29	5	GO:0006650
GeneOntologyBiologicalProcess	phosphatidylinositol metabolic process	PIP5K1A PIP5K1B PIPSL PIP5K1C	9.01e-05	170	29	4	GO:0046488
GeneOntologyBiologicalProcess	phospholipid metabolic process	PIP5K1A PIP5K1B PIPSL PIP5K1C AGPAT2	2.43e-04	410	29	5	GO:0006644
GeneOntologyBiologicalProcess	glycerolipid metabolic process	PIP5K1A PIP5K1B PIPSL PIP5K1C AGPAT2	2.99e-04	429	29	5	GO:0046486
GeneOntologyBiologicalProcess	mammary gland epithelial cell differentiation	LATS1 PTCH1	3.22e-04	19	29	2	GO:0060644
GeneOntologyBiologicalProcess	Rab protein signal transduction	DENND4A DENND4B	3.94e-04	21	29	2	GO:0032482
GeneOntologyCellularComponent	dynein complex	DNAH10 DNAH1 DNAH11	6.30e-05	54	30	3	GO:0030286
GeneOntologyCellularComponent	inner dynein arm	DNAH10 DNAH1	8.90e-05	10	30	2	GO:0036156
GeneOntologyCellularComponent	uropod	PIP5K1B PIP5K1C	1.79e-04	14	30	2	GO:0001931
GeneOntologyCellularComponent	cell trailing edge	PIP5K1B PIP5K1C	2.07e-04	15	30	2	GO:0031254
GeneOntologyCellularComponent	zymogen granule membrane	CUZD1 SCAMP1	3.72e-04	20	30	2	GO:0042589
GeneOntologyCellularComponent	axonemal dynein complex	DNAH10 DNAH1	5.85e-04	25	30	2	GO:0005858
GeneOntologyCellularComponent	zymogen granule	CUZD1 SCAMP1	9.61e-04	32	30	2	GO:0042588
GeneOntologyCellularComponent	secretory granule membrane	CUZD1 MGAM SCAMP1 AGPAT2	1.20e-03	329	30	4	GO:0030667
GeneOntologyCellularComponent	microtubule associated complex	DNAH10 DNAH1 DNAH11	1.56e-03	161	30	3	GO:0005875
GeneOntologyCellularComponent	axoneme	DNAH10 DNAH1 DNAH11	3.19e-03	207	30	3	GO:0005930
GeneOntologyCellularComponent	ciliary plasm	DNAH10 DNAH1 DNAH11	3.23e-03	208	30	3	GO:0097014
Domain	PInositol-4-P-5-kinase	PIP5K1A PIP5K1B PIP5K1C	1.17e-07	7	29	3	IPR023610
Domain	PIPK	PIP5K1A PIP5K1B PIP5K1C	1.87e-07	8	29	3	PS51455
Domain	PIPKc	PIP5K1A PIP5K1B PIP5K1C	1.87e-07	8	29	3	SM00330
Domain	-	PIP5K1A PIP5K1B PIP5K1C	1.87e-07	8	29	3	3.30.800.10
Domain	PInositol-4-P-5-kinase_N	PIP5K1A PIP5K1B PIP5K1C	1.87e-07	8	29	3	IPR027484
Domain	PInositol-4-P-5-kinase_C	PIP5K1A PIP5K1B PIP5K1C	1.87e-07	8	29	3	IPR027483
Domain	-	PIP5K1A PIP5K1B PIP5K1C	1.87e-07	8	29	3	3.30.810.10
Domain	PInositol-4-P-5-kinase_core	PIP5K1A PIP5K1B PIP5K1C	1.87e-07	8	29	3	IPR002498
Domain	PIP5K	PIP5K1A PIP5K1B PIP5K1C	1.87e-07	8	29	3	PF01504
Domain	ATPase_dyneun-rel_AAA	DNAH10 DNAH1 DNAH11	1.21e-06	14	29	3	IPR011704
Domain	Dynein_heavy_chain_D4_dom	DNAH10 DNAH1 DNAH11	1.21e-06	14	29	3	IPR024317
Domain	Dynein_HC_stalk	DNAH10 DNAH1 DNAH11	1.21e-06	14	29	3	IPR024743
Domain	Dynein_heavy_dom-2	DNAH10 DNAH1 DNAH11	1.21e-06	14	29	3	IPR013602
Domain	DHC_N2	DNAH10 DNAH1 DNAH11	1.21e-06	14	29	3	PF08393
Domain	MT	DNAH10 DNAH1 DNAH11	1.21e-06	14	29	3	PF12777
Domain	AAA_8	DNAH10 DNAH1 DNAH11	1.21e-06	14	29	3	PF12780
Domain	AAA_5	DNAH10 DNAH1 DNAH11	1.21e-06	14	29	3	PF07728
Domain	DHC_fam	DNAH10 DNAH1 DNAH11	1.51e-06	15	29	3	IPR026983
Domain	Dynein_heavy_dom	DNAH10 DNAH1 DNAH11	1.51e-06	15	29	3	IPR004273
Domain	Dynein_heavy	DNAH10 DNAH1 DNAH11	1.51e-06	15	29	3	PF03028
Domain	Pentatricopeptide_repeat	PIP5K1B DENND4A DENND4B	5.84e-06	23	29	3	IPR002885
Domain	MABP	DENND4A DENND4B	1.39e-05	4	29	2	IPR023341
Domain	NtCtMGAM_N	MGAM MGAM2	1.39e-05	4	29	2	PF16863
Domain	Gal_mutarotase_N	MGAM MGAM2	1.39e-05	4	29	2	IPR031727
Domain	MABP	DENND4A DENND4B	1.39e-05	4	29	2	PS51498
Domain	Glyco_hydro_31_AS	MGAM MGAM2	3.48e-05	6	29	2	IPR030458
Domain	Glyco_hydro_31	MGAM MGAM2	4.87e-05	7	29	2	PF01055
Domain	Glyco_hydro_31	MGAM MGAM2	4.87e-05	7	29	2	IPR000322
Domain	GLYCOSYL_HYDROL_F31_1	MGAM MGAM2	4.87e-05	7	29	2	PS00129
Domain	Trefoil	MGAM MGAM2	6.48e-05	8	29	2	PF00088
Domain	PPR	DENND4A DENND4B	6.48e-05	8	29	2	PS51375
Domain	Dynein_heavy_dom-1	DNAH10 DNAH11	6.48e-05	8	29	2	IPR013594
Domain	DHC_N1	DNAH10 DNAH11	6.48e-05	8	29	2	PF08385
Domain	P_TREFOIL_2	MGAM MGAM2	8.32e-05	9	29	2	PS51448
Domain	PD	MGAM MGAM2	8.32e-05	9	29	2	SM00018
Domain	-	MGAM MGAM2	1.27e-04	11	29	2	4.10.110.10
Domain	P_trefoil_dom	MGAM MGAM2	1.52e-04	12	29	2	IPR000519
Domain	uDENN	DENND4A DENND4B	2.09e-04	14	29	2	SM00800
Domain	Pept_M10A_Zn_BS	MMP1 MMP12	2.41e-04	15	29	2	IPR021158
Domain	uDENN	DENND4A DENND4B	2.41e-04	15	29	2	PF03456
Domain	DENN	DENND4A DENND4B	2.76e-04	16	29	2	PF02141
Domain	UDENN	DENND4A DENND4B	2.76e-04	16	29	2	PS50946
Domain	DDENN	DENND4A DENND4B	2.76e-04	16	29	2	PS50947
Domain	dDENN_dom	DENND4A DENND4B	2.76e-04	16	29	2	IPR005112
Domain	uDENN_dom	DENND4A DENND4B	2.76e-04	16	29	2	IPR005113
Domain	dDENN	DENND4A DENND4B	2.76e-04	16	29	2	PF03455
Domain	DENN	DENND4A DENND4B	2.76e-04	16	29	2	SM00799
Domain	DENN	DENND4A DENND4B	2.76e-04	16	29	2	PS50211
Domain	DENN_dom	DENND4A DENND4B	2.76e-04	16	29	2	IPR001194
Domain	dDENN	DENND4A DENND4B	2.76e-04	16	29	2	SM00801
Domain	Gal_mutarotase_SF_dom	MGAM MGAM2	3.12e-04	17	29	2	IPR011013
Domain	Hemopexin_CS	MMP1 MMP12	3.12e-04	17	29	2	IPR018486
Domain	Pept_M10A_stromelysin-type	MMP1 MMP12	3.51e-04	18	29	2	IPR016293
Domain	PG_binding_1	MMP1 MMP12	4.35e-04	20	29	2	PF01471
Domain	Peptidoglycan-bd-like	MMP1 MMP12	4.35e-04	20	29	2	IPR002477
Domain	Hemopexin-like_dom	MMP1 MMP12	5.77e-04	23	29	2	IPR000585
Domain	Hemopexin	MMP1 MMP12	5.77e-04	23	29	2	PF00045
Domain	HEMOPEXIN	MMP1 MMP12	5.77e-04	23	29	2	PS00024
Domain	-	MMP1 MMP12	5.77e-04	23	29	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP1 MMP12	5.77e-04	23	29	2	PS51642
Domain	Hemopexin-like_repeat	MMP1 MMP12	5.77e-04	23	29	2	IPR018487
Domain	HX	MMP1 MMP12	5.77e-04	23	29	2	SM00120
Domain	Pept_M10A	MMP1 MMP12	5.77e-04	23	29	2	IPR021190
Domain	M10A_MMP	MMP1 MMP12	5.77e-04	23	29	2	IPR033739
Domain	Peptidase_M10	MMP1 MMP12	6.29e-04	24	29	2	PF00413
Domain	ZnMc	MMP1 MMP12	9.21e-04	29	29	2	SM00235
Domain	Peptidase_Metallo	MMP1 MMP12	9.21e-04	29	29	2	IPR006026
Domain	Pkinase_C	LATS1 SGK3	1.50e-03	37	29	2	IPR017892
Domain	CYSTEINE_SWITCH	MMP1 MMP12	1.84e-03	41	29	2	PS00546
Domain	Pkinase_C	LATS1 SGK3	1.93e-03	42	29	2	PF00433
Domain	Pept_M10_metallopeptidase	MMP1 MMP12	2.02e-03	43	29	2	IPR001818
Domain	Glycoside_hydrolase_SF	MGAM MGAM2	3.05e-03	53	29	2	IPR017853
Domain	AGC-kinase_C	LATS1 SGK3	3.40e-03	56	29	2	IPR000961
Domain	AGC_KINASE_CTER	LATS1 SGK3	3.40e-03	56	29	2	PS51285
Domain	S_TK_X	LATS1 SGK3	3.40e-03	56	29	2	SM00133
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH10 DNAH1 DNAH11	1.78e-05	27	27	3	M47755
Pathway	KEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT	DNAH10 DNAH1 DNAH11	7.35e-05	43	27	3	M47669
Pathway	PID_RHOA_PATHWAY	PIP5K1A PIP5K1B PIP5K1C	8.43e-05	45	27	3	M12
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH10 DNAH1 DNAH11	8.43e-05	45	27	3	M47670
Pathway	WP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY	PIP5K1A PIP5K1B PIP5K1C	9.00e-05	46	27	3	M48317
Pathway	WP_PHOSPHOINOSITIDES_METABOLISM	PIP5K1A PIP5K1B PIP5K1C	1.09e-04	49	27	3	M40046
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	PIP5K1A PIP5K1B PIP5K1C	1.16e-04	50	27	3	MM14641
Pathway	KEGG_MEDICUS_REFERENCE_GLYCOGEN_DEGRADATION_AMYLASE_	MGAM MGAM2	1.26e-04	9	27	2	M47622
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	PIP5K1A PIP5K1B PIP5K1C	1.38e-04	53	27	3	M662
Pathway	KEGG_INOSITOL_PHOSPHATE_METABOLISM	PIP5K1A PIP5K1B PIP5K1C	1.46e-04	54	27	3	M3896
Pathway	PID_RAC1_PATHWAY	PIP5K1A PIP5K1B PIP5K1C	1.46e-04	54	27	3	M278
Pathway	KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	PIP5K1A PIP5K1B PIP5K1C	4.01e-04	76	27	3	M9052
Pathway	REACTOME_PI_METABOLISM	PIP5K1A PIP5K1B PIP5K1C	4.17e-04	77	27	3	MM14590
Pathway	REACTOME_PHOSPHOLIPID_METABOLISM	PIP5K1A PIP5K1B PIP5K1C AGPAT2	4.95e-04	196	27	4	MM14591
Pathway	REACTOME_PI_METABOLISM	PIP5K1A PIP5K1B PIP5K1C	5.38e-04	84	27	3	M676
Pathway	REACTOME_PHOSPHOLIPID_METABOLISM	PIP5K1A PIP5K1B PIP5K1C AGPAT2	6.53e-04	211	27	4	M649
Pathway	BIOCARTA_RHO_PATHWAY	PIP5K1A PIP5K1B	6.57e-04	20	27	2	MM1476
Pathway	BIOCARTA_RHO_PATHWAY	PIP5K1A PIP5K1B	7.25e-04	21	27	2	M1001
Pathway	KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS	PIP5K1A PIP5K1B PIP5K1C	7.95e-04	96	27	3	M16121
Pathway	WP_B_CELL_RECEPTOR_SIGNALING	PIP5K1A PIP5K1B PIP5K1C	8.19e-04	97	27	3	M39323
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	ANO2 RYR3 SGK3	8.69e-04	99	27	3	MM14910
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	ANO2 RYR3 SGK3	1.06e-03	106	27	3	M27200
Pathway	REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK	PIP5K1A PIP5K1B PIP5K1C	1.27e-03	113	27	3	MM14783
Pathway	WP_MATRIX_METALLOPROTEINASES	MMP1 MMP12	1.39e-03	29	27	2	MM15981
Pathway	REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK	PIP5K1A PIP5K1B PIP5K1C	1.44e-03	118	27	3	M713
Pathway	WP_MATRIX_METALLOPROTEINASES	MMP1 MMP12	1.49e-03	30	27	2	M39652
Pathway	WP_REGULATION_OF_ACTIN_CYTOSKELETON	PIP5K1A PIP5K1B PIP5K1C	2.86e-03	150	27	3	M39520
Pathway	WP_REGULATION_OF_ACTIN_CYTOSKELETON	PIP5K1A PIP5K1B PIP5K1C	2.97e-03	152	27	3	MM15834
Pathway	WP_CHRONIC_HYPERGLYCEMIA_IMPAIRMENT_OF_NEURON_FUNCTION	MMP1 MMP12	3.47e-03	46	27	2	M46450
Pubmed	Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42.	PIP5K1A PIP5K1B PIP5K1C	5.79e-10	3	30	3	14681219
Pubmed	PIP5KIβ selectively modulates apical endocytosis in polarized renal epithelial cells.	PIP5K1A PIP5K1B PIP5K1C	5.79e-10	3	30	3	23342003
Pubmed	Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator.	PIP5K1A PIP5K1B PIP5K1C	5.79e-10	3	30	3	22942276
Pubmed	Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes.	PIP5K1A PIP5K1B PIP5K1C	2.32e-09	4	30	3	18188447
Pubmed	Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family.	PIP5K1A PIP5K1B PIP5K1C	2.32e-09	4	30	3	9535851
Pubmed	Identification and characterization of a phosphoinositide phosphate kinase homolog.	PIP5K1A PIP5K1B PIP5K1C	2.32e-09	4	30	3	14701839
Pubmed	The lipid kinase PIP5K1C regulates pain signaling and sensitization.	PIP5K1A PIP5K1B PIP5K1C	5.78e-09	5	30	3	24853942
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	PIP5K1A MMP1 LATS1 MMP12 DNAH10 PIP5K1C POLR2B DNAH11 SGK3	7.26e-09	730	30	9	34857952
Pubmed	Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics.	PIP5K1A PIP5K1B PIP5K1C	1.16e-08	6	30	3	20841379
Pubmed	Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1.	PIP5K1A PIP5K1B PIP5K1C	1.16e-08	6	30	3	14614850
Pubmed	Smurf1 regulates lung cancer cell growth and migration through interaction with and ubiquitination of PIPKIγ.	PIP5K1A PIP5K1B PIP5K1C	1.16e-08	6	30	3	28581524
Pubmed	Localization of mRNAs for phosphatidylinositol phosphate kinases in the mouse brain during development.	PIP5K1A PIP5K1B PIP5K1C	2.02e-08	7	30	3	15018809
Pubmed	Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain.	PIP5K1A PIP5K1B PIP5K1C	3.23e-08	8	30	3	20622009
Pubmed	Btk-dependent regulation of phosphoinositide synthesis.	PIP5K1A PIP5K1B PIP5K1C	3.23e-08	8	30	3	15046600
Pubmed	Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type Iγ in vivo.	PIP5K1A PIP5K1B PIP5K1C	4.85e-08	9	30	3	22976293
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH10 DNAH1 DNAH11	2.09e-07	14	30	3	9373155
Pubmed	Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages.	MMP1 MMP12	7.19e-07	2	30	2	8226919
Pubmed	Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase.	PIP5K1A PIP5K1B	7.19e-07	2	30	2	8798574
Pubmed	Phosphatidylinositol-4-phosphate-5-kinase alpha deficiency alters dynamics of glucose-stimulated insulin release to improve glucohomeostasis and decrease obesity in mice.	PIP5K1A PIP5K1B	7.19e-07	2	30	2	21270258
Pubmed	PI4P5-kinase Ialpha is required for efficient HIV-1 entry and infection of T cells.	PIP5K1A PIP5K1B	7.19e-07	2	30	2	18981107
Pubmed	A central kinase domain of type I phosphatidylinositol phosphate kinases is sufficient to prime exocytosis: isoform specificity and its underlying mechanism.	PIP5K1A PIP5K1B	7.19e-07	2	30	2	15728183
Pubmed	Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes.	PIP5K1A PIP5K1B	7.19e-07	2	30	2	10187762
Pubmed	The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells.	PIP5K1B PIP5K1C	7.19e-07	2	30	2	19549683
Pubmed	PI5KI-dependent signals are critical regulators of the cytolytic secretory pathway.	PIP5K1A PIP5K1C	7.19e-07	2	30	2	18073347
Pubmed	Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling.	PIP5K1A PIP5K1C	7.19e-07	2	30	2	12682053
Pubmed	Type I phosphotidylinosotol 4-phosphate 5-kinase γ regulates osteoclasts in a bifunctional manner.	PIP5K1A PIP5K1C	7.19e-07	2	30	2	23300084
Pubmed	Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking.	MMP1 MMP12	7.19e-07	2	30	2	30789935
Pubmed	The Immunological Roles of Periostin/Tumor-Associated Macrophage Axis in Development of Dermatofibrosarcoma Protuberans.	MMP1 MMP12	7.19e-07	2	30	2	28551623
Pubmed	A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis.	PIP5K1A PIP5K1B	7.19e-07	2	30	2	16979564
Pubmed	MMP Gene Polymorphisms, MMP-1 -1607 1G/2G, -519 A/G, and MMP-12 -82 A/G, and Ischemic Stroke: A Meta-Analysis.	MMP1 MMP12	7.19e-07	2	30	2	28958661
Pubmed	THE ROLE OF POLYMORPHISMS OF MATRIX METALLOPROTEINASES' POLYMORPHISMS 1 AND 12 IN THE FORMATION OF WHEEZING SYNDROME AMONG CHILDREN WITH RECURRENT BRONCHITIS.	MMP1 MMP12	7.19e-07	2	30	2	34459757
Pubmed	PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions.	PIP5K1A PIP5K1C	7.19e-07	2	30	2	19889969
Pubmed	Type I Phosphatidylinositol-4-Phosphate 5-Kinases α and γ Play a Key Role in Targeting HIV-1 Pr55Gag to the Plasma Membrane.	PIP5K1A PIP5K1C	7.19e-07	2	30	2	32376619
Pubmed	Matrix metalloproteinase-1 and matrix metalloproteinase-12 gene polymorphisms and the risk of ischemic stroke in a Tunisian population.	MMP1 MMP12	7.19e-07	2	30	2	24834994
Pubmed	Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis.	PIP5K1A PIP5K1C	7.19e-07	2	30	2	19153220
Pubmed	Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family.	PIP5K1A PIP5K1B	7.19e-07	2	30	2	8955136
Pubmed	Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly.	PIP5K1A PIP5K1B	7.19e-07	2	30	2	10679324
Pubmed	Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.	PIP5K1A PIP5K1B	7.19e-07	2	30	2	18772378
Pubmed	Matrix metalloproteinase-1 and matrix metalloproteinase-12 gene polymorphisms and the outcome of coronary artery disease.	MMP1 MMP12	7.19e-07	2	30	2	21606841
Pubmed	Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella.	DNAH1 DNAH11	7.19e-07	2	30	2	24360805
Pubmed	MMP-1(-1607G) polymorphism as a risk factor for fibrosis after pulmonary tuberculosis in Taiwan.	MMP1 MMP12	2.16e-06	3	30	2	20392358
Pubmed	Polymorphisms in matrix metalloproteinase-1, -9 and -12 genes and the risk of chronic obstructive pulmonary disease in a Korean population.	MMP1 MMP12	2.16e-06	3	30	2	20160424
Pubmed	Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges.	DENND4A DENND4B	2.16e-06	3	30	2	12906859
Pubmed	Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis.	PIP5K1A PIP5K1B	2.16e-06	3	30	2	22321832
Pubmed	Matrix Metalloproteinase Genes (MMP1, MMP10, MMP12) on Chromosome 11q22 and the Risk of Non-Contact Anterior Cruciate Ligament Ruptures.	MMP1 MMP12	2.16e-06	3	30	2	32650441
Pubmed	Matrix metalloprotease polymorphisms are associated with gas transfer in alpha 1 antitrypsin deficiency.	MMP1 MMP12	2.16e-06	3	30	2	19293200
Pubmed	Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer.	MMP1 MMP12	2.16e-06	3	30	2	16311244
Pubmed	Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis.	MMP1 MMP12	2.16e-06	3	30	2	19321798
Pubmed	Association of matrix metalloprotease 1, 3, and 12 polymorphisms with rheumatic heart disease in a Chinese Han population.	MMP1 MMP12	2.16e-06	3	30	2	29458338
Pubmed	Causal Effect of MMP-1 (Matrix Metalloproteinase-1), MMP-8, and MMP-12 Levels on Ischemic Stroke: A Mendelian Randomization Study.	MMP1 MMP12	2.16e-06	3	30	2	33902302
Pubmed	[Study on matrix metalloproteinase 1, 9, 12 polymorphisms and susceptibility to chronic obstructive pulmonary disease among Han nationality in northern China].	MMP1 MMP12	2.16e-06	3	30	2	16676616
Pubmed	CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis.	PIP5K1A PIP5K1C	2.16e-06	3	30	2	33079727
Pubmed	The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function.	MMP1 MMP12	2.16e-06	3	30	2	11875051
Pubmed	[Polymorphism in promoter regions of matrix metalloproteinases (MMP1, MMP9, and MMP12) in chronic obstructive pulmonary disease patients].	MMP1 MMP12	2.16e-06	3	30	2	18619044
Pubmed	Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population.	MMP1 MMP12	2.16e-06	3	30	2	20078883
Pubmed	Matrix metalloproteinase expression by human alveolar macrophages in relation to emphysema.	MMP1 MMP12	2.16e-06	3	30	2	18259971
Pubmed	Matrix metalloproteinase polymorphisms and survival in stage I non-small cell lung cancer.	MMP1 MMP12	4.31e-06	4	30	2	17000679
Pubmed	Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 genes in relation to subarachnoid hemorrhage.	MMP1 MMP12	4.31e-06	4	30	2	11546917
Pubmed	Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia.	DNAH1 DNAH11	4.31e-06	4	30	2	18492703
Pubmed	MMP expression in rheumatoid inflammation: the rs11568818 polymorphism is associated with MMP-7 expression at an extra-articular site.	MMP1 MMP12	4.31e-06	4	30	2	23343931
Pubmed	Molecular motors: the driving force behind mammalian left-right development.	DNAH1 DNAH11	4.31e-06	4	30	2	10652513
Pubmed	[Expression of genes for metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-12) associated with psoriasis].	MMP1 MMP12	4.31e-06	4	30	2	22117411
Pubmed	Association of MMP1, MMP3, MMP9, and MMP12 polymorphisms with risk and clinical course of multiple sclerosis in a Polish population.	MMP1 MMP12	4.31e-06	4	30	2	19628284
Pubmed	Matrix metalloproteinase genes on chromosome 11q22 and the risk of anterior cruciate ligament (ACL) rupture.	MMP1 MMP12	4.31e-06	4	30	2	21410539
Pubmed	Functional polymorphisms in matrix metalloproteinases -1, -3, -9 and -12 in relation to cervical artery dissection.	MMP1 MMP12	4.31e-06	4	30	2	19664242
Pubmed	Complementation of growth factor receptor-dependent mitogenic signaling by a truncated type I phosphatidylinositol 4-phosphate 5-kinase.	PIP5K1A PIP5K1B	4.31e-06	4	30	2	9372970
Pubmed	Role of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 (Lys45Glu), MMP-7 (-181A/G), and MMP-12 (-82A/G) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population.	MMP1 MMP12	4.31e-06	4	30	2	29317790
Pubmed	Alveolar macrophage proteinase/antiproteinase expression in lung function and emphysema.	MMP1 MMP12	4.31e-06	4	30	2	23900981
Pubmed	Expression of metalloproteinases 1, 2, 7, 9, and 12 in human cytotrophoblastic cells from normal and preeclamptic placentas.	MMP1 MMP12	7.18e-06	5	30	2	22936257
Pubmed	Matrix metalloproteinase haplotypes associated with coronary artery aneurysm formation in patients with Kawasaki disease.	MMP1 MMP12	7.18e-06	5	30	2	20827277
Pubmed	Variation in the matrix metalloproteinase-3, -7, -12 and -13 genes is associated with functional status in rheumatoid arthritis.	MMP1 MMP12	7.18e-06	5	30	2	17373931
Pubmed	Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse.	LATS1 PTCH1	7.18e-06	5	30	2	31474569
Pubmed	Altered Expression Levels of MMP1, MMP9, MMP12, TIMP1, and IL-1β as a Risk Factor for the Elevated IOP and Optic Nerve Head Damage in the Primary Open-Angle Glaucoma Patients.	MMP1 MMP12	7.18e-06	5	30	2	26120586
Pubmed	Association of genotypes at the matrix metalloproteinase (MMP) loci with carotid IMT and presence of carotid and femoral atherosclerotic plaques.	MMP1 MMP12	7.18e-06	5	30	2	24043512
Pubmed	Single nucleotide polymorphisms in matrix metalloproteinase genes and lung cancer chemotherapy response and prognosis.	MMP1 MMP12	1.08e-05	6	30	2	19643940
Pubmed	Putative functional polymorphisms of MMP9 predict survival of NSCLC in a Chinese population.	MMP1 MMP12	1.08e-05	6	30	2	19132754
Pubmed	Phosphatidylinositol 4,5-bisphosphate regulates adipocyte actin dynamics and GLUT4 vesicle recycling.	PIP5K1A PIP5K1C	1.08e-05	6	30	2	15123724
Pubmed	Matrix metalloproteinase single-nucleotide polymorphisms and haplotypes predict breast cancer progression.	MMP1 MMP12	1.08e-05	6	30	2	18006768
Pubmed	Matrix metalloproteinase polymorphisms are associated with bladder cancer invasiveness.	MMP1 MMP12	1.08e-05	6	30	2	17473191
Pubmed	Matrix metalloproteinase polymorphisms and bladder cancer risk.	MMP1 MMP12	1.08e-05	6	30	2	17178858
Pubmed	Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact.	MMP1 MMP12	1.08e-05	6	30	2	28122331
Pubmed	Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3.	MMP1 MMP12	1.51e-05	7	30	2	8921407
Pubmed	Matrix metalloproteinases cleave tissue factor pathway inhibitor. Effects on coagulation.	MMP1 MMP12	1.51e-05	7	30	2	10859319
Pubmed	Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation.	MMP1 MMP12	1.51e-05	7	30	2	11113146
Pubmed	Functional polymorphisms and haplotypes in the promoter of the MMP2 gene are associated with risk of nasopharyngeal carcinoma.	MMP1 MMP12	1.51e-05	7	30	2	17607721
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH1 DNAH11	1.51e-05	7	30	2	9256245
Pubmed	Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling.	PTCH1 DNAH11	3.22e-05	10	30	2	21098568
Pubmed	TGF-beta1 induces the different expressions of lysyl oxidases and matrix metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after mechanical injury.	MMP1 MMP12	3.22e-05	10	30	2	23357697
Pubmed	Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity.	LATS1 PTCH1	3.94e-05	11	30	2	25283809
Pubmed	Loss of ciliary transition zone protein TMEM107 leads to heterotaxy in mice.	PTCH1 DNAH11	4.72e-05	12	30	2	31887266
Pubmed	Differential expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) during mouse gonad development.	MMP1 MMP12	5.58e-05	13	30	2	12815621
Pubmed	Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms.	MMP1 MMP12	5.58e-05	13	30	2	15944607
Pubmed	Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.	MMP1 MMP12	6.50e-05	14	30	2	16236725
Pubmed	Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families.	MMP1 MMP12	8.57e-05	16	30	2	20484597
Pubmed	Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor.	MMP1 MMP12	8.57e-05	16	30	2	37701782
Pubmed	Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter.	MMP1 MMP12	1.35e-04	20	30	2	19590686
Pubmed	Matrix metalloproteinases.	MMP1 MMP12	1.64e-04	22	30	2	10419448
Pubmed	Functional interactions between matrix metalloproteinases and glycosaminoglycans.	MMP1 MMP12	1.64e-04	22	30	2	23421805
Pubmed	Atmin mediates kidney morphogenesis by modulating Wnt signaling.	PTCH1 SGK3	1.96e-04	24	30	2	24852369
Pubmed	Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.	PTCH1 DNAH11	2.13e-04	25	30	2	27340223
Interaction	PIP5KL1 interactions	PIP5K1A PIP5K1B PIP5K1C	1.04e-07	7	30	3	int:PIP5KL1
Interaction	PIP5K1B interactions	PIP5K1A PIP5K1B PIP5K1C	8.43e-07	13	30	3	int:PIP5K1B
Interaction	PIP5K1A interactions	PIP5K1A PIP5K1B TRIM25 PIPSL PIP5K1C	3.18e-06	156	30	5	int:PIP5K1A
Interaction	PGBD5 interactions	PIP5K1A PIP5K1C	4.48e-05	7	30	2	int:PGBD5
Interaction	PIP5K1C interactions	PIP5K1A PIP5K1B PIP5K1C	5.57e-05	50	30	3	int:PIP5K1C
Interaction	MGAT5 interactions	TRIM25 PTCH1 ART3	7.41e-05	55	30	3	int:MGAT5
Interaction	HFM1 interactions	HFM1 TRIM25	7.66e-05	9	30	2	int:HFM1
Interaction	MMP17 interactions	MMP1 TRIM25	9.57e-05	10	30	2	int:MMP17
Interaction	SHISAL1 interactions	TRIM25 MFSD5 SCAMP1	9.62e-05	60	30	3	int:SHISAL1
Interaction	PHRF1 interactions	LATS1 POLR2B AGPAT2	1.01e-04	61	30	3	int:PHRF1
Interaction	MMP12 interactions	MMP1 MMP12	1.17e-04	11	30	2	int:MMP12
Interaction	SMURF1 interactions	PIP5K1A PIP5K1B LATS1 PTCH1 PIP5K1C POLR2B	1.29e-04	544	30	6	int:SMURF1
Interaction	PIP5K1P1 interactions	PIP5K1A PIP5K1C	1.40e-04	12	30	2	int:PIP5K1P1
Interaction	PSMD8 interactions	LATS1 TRIM25 PTCH1 GRM2	1.47e-04	182	30	4	int:PSMD8
Cytoband	11q22.3	MMP1 MMP12	3.84e-04	44	30	2	11q22.3
Cytoband	4q12	DCUN1D4 POLR2B	6.00e-04	55	30	2	4q12
Cytoband	Ensembl 112 genes in cytogenetic band chr4q12	DCUN1D4 POLR2B	1.39e-03	84	30	2	chr4q12
Cytoband	Ensembl 112 genes in cytogenetic band chr11q22	MMP1 MMP12	2.24e-03	107	30	2	chr11q22
Cytoband	7q34	MGAM MGAM2	5.35e-03	167	30	2	7q34
Cytoband	Ensembl 112 genes in cytogenetic band chr7q34	MGAM MGAM2	6.52e-03	185	30	2	chr7q34
GeneFamily	Dyneins, axonemal	DNAH10 DNAH1 DNAH11	4.66e-07	17	17	3	536
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP1 MMP12	2.27e-04	24	17	2	891
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND4A DENND4B	2.46e-04	25	17	2	504
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM ANO2 TRANK1 DNAH10 RYR3 DNAH1 DNAH11	3.21e-11	184	30	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM ANO2 TRANK1 DNAH10 RYR3 DNAH1 DNAH11	3.21e-11	184	30	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM ANO2 TRANK1 DNAH10 RYR3 DNAH1 DNAH11	3.21e-11	184	30	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRANK1 DNAH10 RYR3 DNAH1 DNAH11	9.31e-08	169	30	5	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND4A PTCH1 DNAH10 RYR3	6.68e-06	183	30	4	919c9861073d12fd12aecd7469b1478b13838c43
ToppCell	LPS-IL1RA-Epithelial_airway-Ciliated_cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH10 DNAH1 DNAH11	1.41e-04	151	30	3	81cf939ed4df9574fbfff265e109cb9f947d7e6e
ToppCell	LPS-IL1RA-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH10 DNAH1 DNAH11	1.41e-04	151	30	3	9cbcbbc22965a9f0be8364e733d205dd64f2a533
ToppCell	Control-Epithelial_airway-Ciliated_cells-Ciliated\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH10 DNAH1 DNAH11	1.49e-04	154	30	3	4e3bc24043144143842627cacf6f90dda2228910
ToppCell	Control-Epithelial_airway-Ciliated_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH10 DNAH1 DNAH11	1.49e-04	154	30	3	7556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH10 DNAH1 DNAH11	1.49e-04	154	30	3	58072ce422d09f2de602580325eaac6c4ec6c136
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells-Ciliated\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH10 DNAH1 DNAH11	1.49e-04	154	30	3	9ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH10 DNAH1 DNAH11	1.52e-04	155	30	3	5f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNAH10 DNAH1 DNAH11	1.52e-04	155	30	3	0944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell	facs-MAT-Fat-18m-Myeloid-macrophage\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM25 MMP12 SGK3	1.89e-04	167	30	3	c2952d8ba763374c5678b92825c8956fc3e3ecd2
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 DNAH1 DNAH11	1.96e-04	169	30	3	8bca402e144819cb9a8d431d6bf9429be2fff6d6
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 DNAH1 DNAH11	1.96e-04	169	30	3	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH10 DNAH1 DNAH11	2.29e-04	178	30	3	579cdc14f28b459e200ae2102e0bd4df8a2c0dcb
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH10 DNAH1 DNAH11	2.29e-04	178	30	3	b1db59344c074c7c80169fc2c5cd5fc89f3fe463
ToppCell	T_cells-ISG-high_CD4+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	TRANK1 TRIM25 ART3	2.32e-04	179	30	3	af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 DNAH1 DNAH11	2.36e-04	180	30	3	92fb01b91261b3103454924cde56add337b41844
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH10 DNAH1 DNAH11	2.52e-04	184	30	3	d7eccbd21c480d907fdc8eff2bf5ae22ae452221
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH10 DNAH1 DNAH11	2.52e-04	184	30	3	22010cfe0428ebfa40952cc1a1a12ad3d25b35c9
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH10 DNAH1 DNAH11	2.52e-04	184	30	3	264e14aa1859cfc0ed5fb40e97ea189aed9ef4a5
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND4A DNAH10 RYR3	2.56e-04	185	30	3	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PTCH1 SLC16A7 DNAH11	2.60e-04	186	30	3	77bebf576eb9b96ecb4fefb8a82a31aaaa917fc0
ToppCell	368C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PTCH1 SLC16A7 DNAH11	2.60e-04	186	30	3	13bc41c60fd628af31899a5e8b480e06cc4781be
ToppCell	facs-Lung-EPCAM-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH10 DNAH1 DNAH11	2.64e-04	187	30	3	805dafe22f835ece4dd091d8030d0a63b52a48dd
ToppCell	facs-Lung-EPCAM-3m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH10 DNAH1 DNAH11	2.64e-04	187	30	3	04dba2ed09ee4180830bdf0191921696697ea234
ToppCell	T_cells-ISG-high_CD4+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	TRANK1 TRIM25 ART3	2.68e-04	188	30	3	6f8946d4710f6e32c937213f99b790b098b8819c
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	PIP5K1B ART3 SLC16A7	2.77e-04	190	30	3	de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCell	Control-Epithelial\|Control / Condition, Lineage and Cell class	DNAH10 RYR3 DNAH11	2.81e-04	191	30	3	6228302febdb3dffe37dece7062d27ac9ccc6d4b
ToppCell	Control-Epithelial-Ciliated_cells\|Control / Condition, Lineage and Cell class	DNAH10 RYR3 DNAH11	2.81e-04	191	30	3	ea1d2c6838119b7019e9a2ff71d6212262b51b57
ToppCell	Ciliated-cil-3\|World / Class top	DNAH10 DNAH1 DNAH11	2.85e-04	192	30	3	4989ebb8812b8af1870599acd932849122c05a29
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MMP1 PTCH1 RYR3	3.03e-04	196	30	3	1bcae4e0a244af822e2b12b2026a2771316f107d
ToppCell	CV-Mild-1\|CV / Virus stimulation, Condition and Cluster	TRANK1 TRIM25 ART3	3.12e-04	198	30	3	4b078714c49e7befb7b113d72485e712236d35fa
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-Cilia-bearing_cell\|6m / Sample Type, Dataset, Time_group, and Cell type.	PIP5K1B ART3 DNAH11	3.22e-04	200	30	3	177f9ad8dd8635394c575a2b30140184df0bd51e
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DNAH10 DNAH1 DNAH11	3.22e-04	200	30	3	e1dce91c6c531bb212002a14705e496d77ad3490
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DNAH10 DNAH1 DNAH11	3.22e-04	200	30	3	31d75c26055177d656df1fbb10b764cebd61e122
Drug	AC1L1IZE	MGAM ART3 DNAH10 RYR3 DNAH1 DNAH11	1.10e-08	131	28	6	CID000004799
Drug	N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE	MMP1 MMP12	1.46e-06	2	28	2	DB07556
Drug	acetohydroxamic acid	MMP1 MMP12	1.46e-05	5	28	2	ctd:C006358
Drug	Biliton	DNAH10 DNAH1 DNAH11	1.72e-05	41	28	3	CID000002974
Drug	N-methylmesoporphyrin	MMP1 PTCH1 MMP12	1.85e-05	42	28	3	CID000444708
Drug	magnesium	MGAM MMP1 TRIM25 MMP12 DNAH10 RYR3 POLR2B DNAH1 DNAH11	1.88e-05	1325	28	9	CID000000888
Drug	mag-indo-1	MGAM RYR3	3.05e-05	7	28	2	CID000131881
Drug	vanadyl	MGAM ART3 DNAH10 DNAH1 DNAH11	3.29e-05	307	28	5	CID000061671
Drug	Marimastat	MMP1 MMP12	4.07e-05	8	28	2	DB00786
Drug	strychnine HCl	MGAM PTCH1 GRM2 MMP12	6.81e-05	181	28	4	CID000005304
Drug	A-C-A	MGAM MMP1 ART3	7.57e-05	67	28	3	CID015955872
Drug	Cyclopenthiazide [742-20-1]; Down 200; 10.6uM; PC3; HT_HG-U133A	CUZD1 DENND4A TRIM25 PTCH1	9.09e-05	195	28	4	4229_DN
Drug	AC1L9NAZ	ANO2 LATS1 GRM2 SLC16A7	9.65e-05	198	28	4	CID000449606
Drug	C070379	GRM2 MMP12 ART3 RYR3	9.84e-05	199	28	4	CID003034747
Drug	Rifampicin [13292-46-1]; Down 200; 4.8uM; HL60; HT_HG-U133A	TRANK1 LATS1 TRIM25 PTCH1	9.84e-05	199	28	4	2487_DN
Drug	ethosuximide	PTCH1 MMP12 RYR3	1.02e-04	74	28	3	CID000003291
Drug	AC1OAGGW	PIP5K1A PIP5K1B ART3 PIP5K1C	1.06e-04	203	28	4	CID006857364
Drug	NSC299933	MGAM RYR3	1.13e-04	13	28	2	CID000431902
Drug	pH Q	MMP1 PTCH1 SCAMP1	1.24e-04	79	28	3	CID000007708
Drug	Ageladine A	MMP1 MMP12	1.32e-04	14	28	2	ctd:C482289
Drug	nifedipine	MMP1 TRIM25 GRM2 ART3 RYR3	1.37e-04	415	28	5	CID000004485
Drug	XeC compound	GRM2 ART3 RYR3	1.48e-04	84	28	3	CID000005701
Drug	tetradotoxin	MGAM PTCH1 GRM2 MMP12 ART3	1.58e-04	428	28	5	CID000020382
Drug	carbachol	MMP1 GRM2 MMP12 ART3 PIP5K1C RYR3	1.59e-04	688	28	6	CID000002551
Drug	europium	MGAM RYR3 POLR2B	1.65e-04	87	28	3	CID000023981
Drug	potassium	MGAM PTCH1 GRM2 MMP12 ART3 RYR3 SGK3	1.71e-04	1008	28	7	CID000000813
Drug	forskolin from Coleus forskohlii	MMP1 LATS1 TRIM25 PTCH1 GRM2 ART3 RYR3	1.76e-04	1013	28	7	CID000003413
Drug	MMI270	MMP1 MMP12	2.20e-04	18	28	2	CID000446504
Drug	IC261	DNAH10 DNAH1 DNAH11	2.20e-04	96	28	3	CID000003674
Drug	nitrendipine	MMP12 ART3 RYR3	2.34e-04	98	28	3	CID000004507
Drug	uranium	MGAM ANO2 LATS1 POLR2B	2.43e-04	252	28	4	CID000023989
Drug	AC1L380G	MGAM RYR3	2.46e-04	19	28	2	CID000084698
Drug	aluminum citrate	MGAM SLC16A7	2.73e-04	20	28	2	CID000091599
Drug	hydroxylysine	MGAM MMP1 LATS1	3.20e-04	109	28	3	CID000001029
Drug	DPCPX	GRM2 MMP12 ART3	3.94e-04	117	28	3	CID000001329
Drug	potassium cyanate	LATS1 TRIM25	3.96e-04	24	28	2	CID011378442
Drug	ng h	MMP1 MMP12	4.30e-04	25	28	2	CID000448002
Drug	DA-125	MMP1 MMP12	4.65e-04	26	28	2	CID000114758
Drug	CNQX	TRIM25 PTCH1 GRM2	4.90e-04	126	28	3	CID000002821
Drug	2-aminoethyl diphenylborinate	GRM2 ART3 RYR3	5.01e-04	127	28	3	CID000001598
Drug	benzylamide	MMP1 PTCH1	5.02e-04	27	28	2	CID000010391
Drug	rhod-2	GRM2 RYR3	5.40e-04	28	28	2	CID000123669
Drug	lanthanum	MGAM MMP12 RYR3	6.12e-04	136	28	3	CID000023926
Drug	cis-2,3-piperidine dicarboxylic acid	MGAM GRM2	6.21e-04	30	28	2	CID000001226
Drug	Ataa	MMP1 MMP12	6.21e-04	30	28	2	CID000195836
Drug	mercuric acetate	MMP1 MMP12	6.21e-04	30	28	2	CID000015337
Drug	BAPTA	GRM2 MMP12 ART3 RYR3	6.29e-04	324	28	4	CID000104751
Drug	Vgvapg	MMP1 MMP12	6.63e-04	31	28	2	CID000124934
Drug	malolactomycin D	MMP1 MMP12	7.07e-04	32	28	2	CID006449115
Drug	DE gel	MGAM TRIM25 GRM2	7.08e-04	143	28	3	CID000008146
Drug	Dantrolene-13C3	GRM2 MMP12 RYR3	7.37e-04	145	28	3	CID000002951
Drug	nimodipine	GRM2 ART3 RYR3	7.37e-04	145	28	3	CID000004497
Drug	acetate	MGAM MMP1 MMP12 DNAH1 DNAH11	7.38e-04	599	28	5	CID000000175
Drug	macrocyclic inhibitor 4	MMP1 MMP12	7.52e-04	33	28	2	CID016124959
Drug	AC1Q5UBL	PTCH1 GRM2 ART3	7.52e-04	146	28	3	CID000005466
Drug	Bay K 8644	MGAM ART3 RYR3	8.14e-04	150	28	3	CID000002303
Drug	tyrphostin A1	LATS1 PTCH1	8.46e-04	35	28	2	CID000002063
Drug	sodium	MGAM MMP1 MMP12 ART3 RYR3 SGK3	8.60e-04	944	28	6	CID000000923
Drug	isoflavone	MMP1 TRIM25 MMP12	8.95e-04	155	28	3	CID000072304
Drug	3-7a	MGAM MMP12	8.95e-04	36	28	2	CID011987860
Drug	CaCl2	MGAM MMP1 MMP12	9.11e-04	156	28	3	CID000024854
Drug	monomethyl phthalate	PIP5K1B MGAM MMP1 LATS1 SLC16A7 SGK3	9.24e-04	957	28	6	ctd:C517284
Drug	Compound 10	PTCH1 GRM2	9.46e-04	37	28	2	CID003749170
Drug	mag-fura-2	MGAM RYR3	9.46e-04	37	28	2	CID000123839
Drug	benzyloxyaspartate	PTCH1 GRM2	9.46e-04	37	28	2	CID004133412
Drug	gamma-Glu-Gly	MGAM GRM2	9.46e-04	37	28	2	CID000100099
Drug	SAHA; Up 200; 10uM; PC3; HT_HG-U133A	MMP1 TRIM25 PTCH1	9.81e-04	160	28	3	1220_UP
Drug	DMCM	PTCH1 GRM2	9.98e-04	38	28	2	CID000104999
Drug	Ni-Fe active center	MGAM MMP12	1.05e-03	39	28	2	CID005195770
Drug	cerium	MGAM ANO2	1.05e-03	39	28	2	CID000008762
Drug	latanoprost acid	MMP1 MMP12	1.11e-03	40	28	2	CID006441636
Drug	epps	MMP12 RYR3	1.11e-03	40	28	2	CID000085255
Drug	AC1L9GJJ	MMP12 ART3	1.11e-03	40	28	2	CID000444570
Drug	CGP55845	GRM2 ART3	1.16e-03	41	28	2	CID000123885
Drug	titanium	MGAM MMP1 MMP12	1.17e-03	170	28	3	CID000023963
Drug	Tetracycline	PIP5K1A PIP5K1B DCUN1D4 SLC16A7 AGPAT2	1.20e-03	668	28	5	ctd:D013752
Drug	AC1L1BV0	MMP1 MMP12	1.22e-03	42	28	2	CID000001620
Disease	cancer (implicated_via_orthology)	PIP5K1A PIP5K1B LATS1 PIPSL PIP5K1C	7.05e-06	268	30	5	DOID:162 (implicated_via_orthology)
Disease	Barrett's esophagus (is_implicated_in)	MMP1 MMP12	5.46e-05	11	30	2	DOID:9206 (is_implicated_in)
Disease	abdominal aortic aneurysm (is_implicated_in)	MMP1 MMP12	6.55e-05	12	30	2	DOID:7693 (is_implicated_in)
Disease	thoracic aortic aneurysm (is_marker_for)	MMP1 MMP12	9.02e-05	14	30	2	DOID:14004 (is_marker_for)
Disease	esophagus adenocarcinoma (is_implicated_in)	MMP1 MMP12	2.07e-04	21	30	2	DOID:4914 (is_implicated_in)
Disease	Pigmented Basal Cell Carcinoma	LATS1 PTCH1	3.72e-04	28	30	2	C1368275
Disease	Carcinoma, Basal Cell	LATS1 PTCH1	3.99e-04	29	30	2	C4721806
Disease	1,5 anhydroglucitol measurement	MGAM MGAM2	3.99e-04	29	30	2	EFO_0008009
Disease	arteriosclerosis (is_implicated_in)	MMP1 MMP12	4.56e-04	31	30	2	DOID:2349 (is_implicated_in)
Disease	Primary ciliary dyskinesia	DNAH1 DNAH11	6.16e-04	36	30	2	cv:C0008780
Disease	Primary Ciliary Dyskinesia	DNAH1 DNAH11	1.05e-03	47	30	2	C4551720
Disease	interleukin 1 receptor antagonist measurement	TRANK1 DNAH11	1.33e-03	53	30	2	EFO_0004754
Disease	brain measurement, neuroimaging measurement	ANO2 LATS1 PTCH1 DNAH11	2.23e-03	550	30	4	EFO_0004346, EFO_0004464
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	HFM1 DNAH10 DNAH1	2.73e-03	276	30	3	EFO_0004612, EFO_0020943

Protein segments in the cluster

Peptide	Gene	Start	Entry
TNFKLIYRYAFDFAR	DCUN1D4	191	Q92564
SRYDYFARTVPPDFF	GRM2	176	Q14416
EYLETKRIAFPRFYF	DNAH11	1616	Q96DT5
YSPIFYVAFFKGRFV	ANO2	636	Q9NQ90
FFDAFRKFLTFLYRY	DENND4A	321	Q7Z401
DAAVFNPRFYRTYFF	MMP12	381	P39900
YRAYVAFPDFFRNST	MGAM2	1331	Q2M2H8
YEFTFRRFFDDNGYP	LATS1	1076	O95835
YRAYVAFPDFFRNST	MGAM	1376	O43451
LYRAYVAFPDFFRNS	MGAM	2271	O43451
FRFKTYAPLAFRYFR	PIP5K1B	81	O14986
SKYIRPRIQYFFSFA	SLC16A7	306	O60669
DFRFKTYAPVAFRYF	PIP5K1A	136	Q99755
YNAFRFKTYAPVAFR	PIPSL	81	A2A3N6
FRSIFKEFPYFNYIQ	HFM1	271	A2PYH4
EYLETKRSAFPRFYF	DNAH1	1316	Q9P2D7
AFPAFRAFLTFLYRY	DENND4B	326	O75064
SARIQRTVFVFYYFF	CUZD1	131	Q86UP6
DYLDSKRNAFPRFFF	DNAH10	1556	Q8IVF4
FVFRRYAEFDKLYNT	SGK3	46	Q96BR1
PSFLRFQLDFYQVYF	MFSD5	36	Q6N075
FVRSFKYFYGLRFEV	AGPAT2	66	O15120
FFKDRFYMRTNPFYP	MMP1	296	P03956
FRFKTYAPVAFRYFR	PIP5K1C	131	O60331
REYDFIAAQFKYFSF	PTCH1	786	Q13635
VDRGFFRSVFYRSYK	POLR2B	801	P30876
RSDSSFRFFVFFFVY	SCAMP1	211	O15126
VYLYTVVAFNFFRKF	RYR3	4681	Q15413
YKFRVDFTEALYPAF	TRIM25	601	Q14258
PNYKSFRFYRFALKE	TRANK1	2251	O15050
REDYIYGFQFKAFHF	ART3	126	Q13508