Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionacetylcholine receptor regulator activity

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

3.04e-1127466GO:0030548
GeneOntologyMolecularFunctionneurotransmitter receptor regulator activity

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

3.86e-1128466GO:0099602
GeneOntologyMolecularFunctionSUMO ligase activity

RGPD1 RGPD4 RGPD8 RGPD3

1.16e-0720464GO:0061665
GeneOntologyMolecularFunctionprotein kinase binding

SPDYE1 SPDYE21 SPDYE5 SPDYE18 CCDC102B SPDYE2B MTOR KCNH1 RPTOR SPDYE6 SPDYE16 SPDYE2

4.45e-078734612GO:0019901
GeneOntologyMolecularFunctionkinase binding

SPDYE1 SPDYE21 SPDYE5 SPDYE18 CCDC102B SPDYE2B MTOR KCNH1 RPTOR SPDYE6 SPDYE16 SPDYE2

1.34e-069694612GO:0019900
GeneOntologyMolecularFunctionSUMO transferase activity

RGPD1 RGPD4 RGPD8 RGPD3

1.38e-0636464GO:0019789
GeneOntologyMolecularFunctionGTPase binding

RGPD1 RGPD4 ALS2 GAPVD1 RGPD8 IARS1 RPTOR RGPD3

1.48e-06360468GO:0051020
GeneOntologyMolecularFunctionGTPase activator activity

RGPD1 RGPD4 ALS2 GAPVD1 RGPD8 RGPD3 RGPD5

3.24e-06279467GO:0005096
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

RGPD1 RGPD4 RGPD8 RGPD3

5.25e-0650464GO:0003755
GeneOntologyMolecularFunctioncis-trans isomerase activity

RGPD1 RGPD4 RGPD8 RGPD3

6.64e-0653464GO:0016859
GeneOntologyMolecularFunctionsmall GTPase binding

RGPD1 RGPD4 ALS2 GAPVD1 RGPD8 RPTOR RGPD3

8.12e-06321467GO:0031267
GeneOntologyMolecularFunctionenzyme activator activity

RGPD1 RGPD4 ALS2 GAPVD1 RGPD8 RPTOR DDX3X RGPD3 RGPD5

1.57e-05656469GO:0008047
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

RGPD1 RGPD4 ALS2 GAPVD1 RGPD8 RGPD3 RGPD5

1.48e-04507467GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

RGPD1 RGPD4 ALS2 GAPVD1 RGPD8 RGPD3 RGPD5

1.48e-04507467GO:0030695
GeneOntologyMolecularFunctioncalcium channel activity

TRPV1 TRPC7 TRPC6 PKD1L1

2.20e-04129464GO:0005262
GeneOntologyMolecularFunctionprimary miRNA binding

DROSHA DDX3X

2.31e-0410462GO:0070878
GeneOntologyMolecularFunctionstore-operated calcium channel activity

TRPC7 TRPC6

3.38e-0412462GO:0015279
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

TRPV1 TRPC7 TRPC6 PKD1L1

4.01e-04151464GO:0015085
GeneOntologyMolecularFunctionmolecular function activator activity

RGPD1 RGPD4 ALS2 GAPVD1 RGPD8 GFER RPTOR DDX3X RGPD3 RGPD5

4.11e-0412334610GO:0140677
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

TRPC7 TRPC6

4.64e-0414462GO:0070679
GeneOntologyMolecularFunctionsignaling receptor regulator activity

SPDYE1 SPDYE5 SPDYE2B GFER SPDYE6 SPDYE16 SPDYE2

4.83e-04616467GO:0030545
GeneOntologyMolecularFunctionmonoatomic ion channel activity

TRPV1 TRPC7 CLCN3 KCNH1 TRPC6 PKD1L1

6.14e-04459466GO:0005216
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

TRPV1 TRPC7 SLC4A8 KCNH1 TRPC6 PKD1L1

6.57e-04465466GO:0046873
GeneOntologyMolecularFunctionisomerase activity

RGPD1 RGPD4 RGPD8 RGPD3

9.86e-04192464GO:0016853
GeneOntologyMolecularFunctionmonoatomic cation channel activity

TRPV1 TRPC7 KCNH1 TRPC6 PKD1L1

1.12e-03343465GO:0005261
GeneOntologyMolecularFunctionchannel activity

TRPV1 TRPC7 CLCN3 KCNH1 TRPC6 PKD1L1

1.23e-03525466GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

TRPV1 TRPC7 CLCN3 KCNH1 TRPC6 PKD1L1

1.24e-03526466GO:0022803
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

TRPV1 TRPC7 SLC4A8 CLCN3 KCNH1 TRPC6 PKD1L1

1.63e-03758467GO:0015318
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

TRPV1 TRPC7 SLC4A8 CLCN3 KCNH1 TRPC6 PKD1L1

2.10e-03793467GO:0015075
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

RGPD1 RGPD4 RGPD8 GID4 RGPD3

2.15e-03398465GO:0061659
GeneOntologyMolecularFunctionphosphoprotein binding

DPYSL3 TRPV1 MTOR

2.48e-03117463GO:0051219
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

TRPV1 TRPC7 SLC4A8 KCNH1 TRPC6 PKD1L1

3.01e-03627466GO:0022890
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

TRPV1 TRPC7 SLC4A8 KCNH1 TRPC6 PKD1L1

3.99e-03664466GO:0008324
GeneOntologyMolecularFunction14-3-3 protein binding

KCNH1 RPTOR

4.22e-0342462GO:0071889
GeneOntologyMolecularFunctionenzyme regulator activity

RGPD1 RGPD4 ALS2 GAPVD1 RGPD8 RPTOR DDX3X RGPD3 RGPD5

4.50e-031418469GO:0030234
GeneOntologyMolecularFunctionprotein kinase activator activity

ALS2 RPTOR DDX3X

4.89e-03149463GO:0030295
GeneOntologyMolecularFunctionkinase activator activity

ALS2 RPTOR DDX3X

5.85e-03159463GO:0019209
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

RGPD1 RGPD4 RGPD8 GID4 RGPD3

6.27e-03512465GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

RGPD1 RGPD4 RGPD8 GID4 RGPD3

7.34e-03532465GO:0016755
GeneOntologyMolecularFunctionacyltransferase activity

RGPD1 RGPD4 NAA40 RGPD8 GID4 RGPD3

8.36e-03775466GO:0016746
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

TRPV1 CLCN3 KCNH1

8.48e-03182463GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

TRPV1 CLCN3 KCNH1

8.74e-03184463GO:0022832
GeneOntologyBiologicalProcesspositive regulation of kinase activity

RGPD1 RGPD4 SPDYE1 ALS2 SPDYE5 RGPD8 SPDYE2B MTOR DDX3X SPDYE6 RGPD3 SPDYE16 SPDYE2

1.59e-124054413GO:0033674
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

1.14e-1125446GO:0045737
GeneOntologyBiologicalProcesspositive regulation of transferase activity

RGPD1 RGPD4 SPDYE1 ALS2 SPDYE5 RGPD8 SPDYE2B MTOR DDX3X SPDYE6 RGPD3 SPDYE16 SPDYE2

1.74e-114904413GO:0051347
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein kinase activity

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

2.40e-1128446GO:1904031
GeneOntologyBiologicalProcesspositive regulation of phosphorylation

RGPD1 RGPD4 SPDYE1 ALS2 SPDYE5 RGPD8 SPDYE2B MTOR RPTOR DDX3X SPDYE6 RGPD3 TRPC6 SPDYE16 SPDYE2

3.35e-117804415GO:0042327
GeneOntologyBiologicalProcesspositive regulation of phosphate metabolic process

RGPD1 RGPD4 SPDYE1 ALS2 SPDYE5 RGPD8 SPDYE2B MTOR RPTOR DDX3X SPDYE6 RGPD3 TRPC6 SPDYE16 SPDYE2

1.78e-108794415GO:0045937
GeneOntologyBiologicalProcesspositive regulation of phosphorus metabolic process

RGPD1 RGPD4 SPDYE1 ALS2 SPDYE5 RGPD8 SPDYE2B MTOR RPTOR DDX3X SPDYE6 RGPD3 TRPC6 SPDYE16 SPDYE2

1.78e-108794415GO:0010562
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

5.29e-1020445GO:0006607
GeneOntologyBiologicalProcessregulation of kinase activity

RGPD1 RGPD4 SPDYE1 ALS2 SPDYE5 RGPD8 SPDYE2B MTOR DDX3X SPDYE6 RGPD3 SPDYE16 SPDYE2

1.09e-096864413GO:0043549
GeneOntologyBiologicalProcesspositive regulation of glucokinase activity

RGPD1 RGPD4 RGPD8 RGPD3

2.25e-099444GO:0033133
GeneOntologyBiologicalProcesspositive regulation of hexokinase activity

RGPD1 RGPD4 RGPD8 RGPD3

3.75e-0910444GO:1903301
GeneOntologyBiologicalProcessregulation of transferase activity

RGPD1 RGPD4 SPDYE1 ALS2 SPDYE5 RGPD8 SPDYE2B MTOR DDX3X SPDYE6 RGPD3 SPDYE16 SPDYE2

8.07e-098104413GO:0051338
GeneOntologyBiologicalProcesspositive regulation of cell cycle

SPDYE1 YTHDC2 SPDYE5 RRM2 SPDYE2B RPTOR DDX3X SPDYE6 SPDYE16 SPDYE2

1.09e-084074410GO:0045787
GeneOntologyBiologicalProcessregulation of glucokinase activity

RGPD1 RGPD4 RGPD8 RGPD3

1.27e-0813444GO:0033131
GeneOntologyBiologicalProcessregulation of phosphorylation

RGPD1 RGPD4 SPDYE1 ALS2 SPDYE5 RGPD8 SPDYE2B MTOR RPTOR DDX3X SPDYE6 RGPD3 TRPC6 SPDYE16 SPDYE2

1.68e-0812264415GO:0042325
GeneOntologyBiologicalProcessregulation of hexokinase activity

RGPD1 RGPD4 RGPD8 RGPD3

1.77e-0814444GO:1903299
GeneOntologyBiologicalProcesspositive regulation of protein kinase activity

SPDYE1 ALS2 SPDYE5 SPDYE2B MTOR DDX3X SPDYE6 SPDYE16 SPDYE2

4.42e-08350449GO:0045860
GeneOntologyBiologicalProcessregulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

5.31e-0896446GO:0000079
GeneOntologyBiologicalProcessregulation of cyclin-dependent protein kinase activity

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

6.79e-08100446GO:1904029
GeneOntologyBiologicalProcessregulation of phosphate metabolic process

RGPD1 RGPD4 SPDYE1 ALS2 SPDYE5 RGPD8 SPDYE2B MTOR RPTOR DDX3X SPDYE6 RGPD3 TRPC6 SPDYE16 SPDYE2

1.19e-0714214415GO:0019220
GeneOntologyBiologicalProcessregulation of phosphorus metabolic process

RGPD1 RGPD4 SPDYE1 ALS2 SPDYE5 RGPD8 SPDYE2B MTOR RPTOR DDX3X SPDYE6 RGPD3 TRPC6 SPDYE16 SPDYE2

1.21e-0714234415GO:0051174
GeneOntologyBiologicalProcesspositive regulation of catalytic activity

RGPD1 RGPD4 SPDYE1 ALS2 SPDYE5 RGPD8 SPDYE2B MTOR DDX3X SPDYE6 RGPD3 SPDYE16 SPDYE2

1.33e-0710284413GO:0043085
GeneOntologyBiologicalProcesspositive regulation of protein serine/threonine kinase activity

SPDYE1 SPDYE5 SPDYE2B DDX3X SPDYE6 SPDYE16 SPDYE2

1.61e-07193447GO:0071902
GeneOntologyBiologicalProcesspositive regulation of protein phosphorylation

SPDYE1 ALS2 SPDYE5 SPDYE2B MTOR RPTOR DDX3X SPDYE6 TRPC6 SPDYE16 SPDYE2

2.46e-077244411GO:0001934
GeneOntologyBiologicalProcesspositive regulation of molecular function

RGPD1 RGPD4 SPDYE1 ALS2 SPDYE5 RGPD8 SPDYE2B MTOR DDX3X SPDYE6 RGPD3 TRPC6 SPDYE16 SPDYE2

8.87e-0714304414GO:0044093
GeneOntologyBiologicalProcessprotein peptidyl-prolyl isomerization

RGPD1 RGPD4 RGPD8 RGPD3

1.26e-0638444GO:0000413
GeneOntologyBiologicalProcesspositive regulation of protein modification process

SPDYE1 ALS2 SPDYE5 SPDYE2B MTOR RPTOR DDX3X SPDYE6 TRPC6 SPDYE16 SPDYE2

3.10e-069374411GO:0031401
GeneOntologyBiologicalProcessregulation of protein kinase activity

SPDYE1 ALS2 SPDYE5 SPDYE2B MTOR DDX3X SPDYE6 SPDYE16 SPDYE2

4.65e-06611449GO:0045859
GeneOntologyBiologicalProcesspeptidyl-proline modification

RGPD1 RGPD4 RGPD8 RGPD3

5.27e-0654444GO:0018208
GeneOntologyBiologicalProcessregulation of carbohydrate biosynthetic process

RGPD1 RGPD4 RGPD8 MTOR RGPD3

8.84e-06132445GO:0043255
GeneOntologyBiologicalProcessregulation of carbohydrate metabolic process

RGPD1 RGPD4 RGPD8 MTOR RPTOR RGPD3

9.15e-06231446GO:0006109
GeneOntologyBiologicalProcessregulation of protein serine/threonine kinase activity

SPDYE1 SPDYE5 SPDYE2B DDX3X SPDYE6 SPDYE16 SPDYE2

9.87e-06358447GO:0071900
GeneOntologyBiologicalProcessmRNA transport

RGPD1 RGPD4 CASC3 RGPD8 RGPD3

1.40e-05145445GO:0051028
GeneOntologyBiologicalProcessregulation of gluconeogenesis

RGPD1 RGPD4 RGPD8 RGPD3

1.58e-0571444GO:0006111
GeneOntologyBiologicalProcessregulation of protein phosphorylation

SPDYE1 ALS2 SPDYE5 SPDYE2B MTOR RPTOR DDX3X SPDYE6 TRPC6 SPDYE16 SPDYE2

1.88e-0511334411GO:0001932
GeneOntologyBiologicalProcesspositive regulation of pentose-phosphate shunt

MTOR RPTOR

2.66e-054442GO:1905857
GeneOntologyBiologicalProcessRNA transport

RGPD1 RGPD4 CASC3 RGPD8 RGPD3

3.45e-05175445GO:0050658
GeneOntologyBiologicalProcessnucleic acid transport

RGPD1 RGPD4 CASC3 RGPD8 RGPD3

3.45e-05175445GO:0050657
GeneOntologyBiologicalProcessestablishment of RNA localization

RGPD1 RGPD4 CASC3 RGPD8 RGPD3

3.74e-05178445GO:0051236
GeneOntologyBiologicalProcessnuclear export

RGPD1 RGPD4 CASC3 RGPD8 RGPD3

4.50e-05185445GO:0051168
GeneOntologyBiologicalProcessprotein import into nucleus

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

5.78e-05195445GO:0006606
GeneOntologyBiologicalProcessimport into nucleus

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

6.67e-05201445GO:0051170
GeneOntologyBiologicalProcessgluconeogenesis

RGPD1 RGPD4 RGPD8 RGPD3

9.13e-05111444GO:0006094
GeneOntologyBiologicalProcessregulation of pentose-phosphate shunt

MTOR RPTOR

9.28e-057442GO:0043456
GeneOntologyBiologicalProcessRNA localization

RGPD1 RGPD4 CASC3 RGPD8 RGPD3

9.57e-05217445GO:0006403
GeneOntologyBiologicalProcesshexose biosynthetic process

RGPD1 RGPD4 RGPD8 RGPD3

1.05e-04115444GO:0019319
GeneOntologyBiologicalProcessprotein localization to nucleus

RGPD1 RGPD4 RGPD8 MTOR RGPD3 RGPD5

1.13e-04362446GO:0034504
GeneOntologyBiologicalProcessmonosaccharide biosynthetic process

RGPD1 RGPD4 RGPD8 RGPD3

1.28e-04121444GO:0046364
GeneOntologyBiologicalProcessnuclear transport

RGPD1 RGPD4 CASC3 RGPD8 RGPD3 RGPD5

1.43e-04378446GO:0051169
GeneOntologyBiologicalProcessnucleocytoplasmic transport

RGPD1 RGPD4 CASC3 RGPD8 RGPD3 RGPD5

1.43e-04378446GO:0006913
GeneOntologyBiologicalProcesscarbohydrate biosynthetic process

RGPD1 RGPD4 RGPD8 MTOR RGPD3

1.75e-04247445GO:0016051
GeneOntologyBiologicalProcessnucleobase-containing compound transport

RGPD1 RGPD4 CASC3 RGPD8 RGPD3

1.82e-04249445GO:0015931
GeneOntologyBiologicalProcesspositive regulation of protein metabolic process

SPDYE1 ALS2 SPDYE5 SPDYE2B MTOR RPTOR DDX3X SPDYE6 TRPC6 SPDYE16 SPDYE2

1.85e-0414584411GO:0051247
GeneOntologyBiologicalProcessregulation of glucose metabolic process

RGPD1 RGPD4 RGPD8 RGPD3

1.89e-04134444GO:0010906
GeneOntologyBiologicalProcessregulation of NADP metabolic process

MTOR RPTOR

1.98e-0410442GO:1902031
GeneOntologyBiologicalProcessregulation of protein modification process

SPDYE1 ALS2 SPDYE5 SPDYE2B MTOR RPTOR DDX3X SPDYE6 TRPC6 SPDYE16 SPDYE2

2.21e-0414884411GO:0031399
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

TRPV1 TRPC7 SLC4A8 CLCN3 MTOR KCNH1 SCARA5 TRPC6 PKD1L1

2.47e-041017449GO:0098660
GeneOntologyBiologicalProcessregulation of cell cycle

SPDYE1 YTHDC2 SPDYE5 RRM2 SPDYE2B RPTOR DDX3X SPDYE6 SPDYE16 SPDYE2

2.50e-0412564410GO:0051726
GeneOntologyBiologicalProcessregulation of small molecule metabolic process

RGPD1 RGPD4 RGPD8 MTOR RPTOR RGPD3

3.01e-04434446GO:0062012
GeneOntologyBiologicalProcesscellular response to L-leucine

MTOR RPTOR

3.42e-0413442GO:0071233
GeneOntologyBiologicalProcesspositive regulation of G1/S transition of mitotic cell cycle

RRM2 RPTOR DDX3X

3.45e-0464443GO:1900087
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

TRPV1 TRPC7 SLC4A8 CLCN3 MTOR KCNH1 SCARA5 TRPC6 PKD1L1

4.87e-041115449GO:0034220
GeneOntologyBiologicalProcesscellular response to osmotic stress

MTOR RPTOR DDX3X

4.87e-0472443GO:0071470
GeneOntologyBiologicalProcessresponse to L-leucine

MTOR RPTOR

5.24e-0416442GO:0043201
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

TRPV1 TRPC7 SLC4A8 CLCN3 KCNH1 SCARA5 TRPC6 PKD1L1

6.54e-04922448GO:0098662
GeneOntologyBiologicalProcesspositive regulation of cell cycle G1/S phase transition

RRM2 RPTOR DDX3X

6.64e-0480443GO:1902808
GeneOntologyBiologicalProcesscellular response to heat

TRPV1 MTOR SCARA5

6.88e-0481443GO:0034605
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

TRPV1 TRPC7 SLC4A8 CLCN3 KCNH1 SCARA5 TRPC6 PKD1L1

7.53e-04942448GO:0098655
GeneOntologyBiologicalProcessregulation of cytosolic calcium ion concentration

TRPC7 KCNH1 TRPC6

7.65e-0484443GO:0051480
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase III

MTOR RPTOR

8.25e-0420442GO:0045945
GeneOntologyBiologicalProcessprimary miRNA processing

DROSHA DDX3X

8.25e-0420442GO:0031053
GeneOntologyBiologicalProcesspyrimidine nucleobase metabolic process

DPYSL3 MTOR

1.00e-0322442GO:0006206
GeneOntologyBiologicalProcesspentose-phosphate shunt

MTOR RPTOR

1.00e-0322442GO:0006098
GeneOntologyBiologicalProcessNADPH regeneration

MTOR RPTOR

1.29e-0325442GO:0006740
GeneOntologyBiologicalProcesspositive regulation of glycolytic process

MTOR RPTOR

1.74e-0329442GO:0045821
GeneOntologyBiologicalProcesspositive regulation of nucleotide catabolic process

MTOR RPTOR

1.74e-0329442GO:0030813
GeneOntologyBiologicalProcesspositive regulation of translational initiation

MTOR DDX3X

1.74e-0329442GO:0045948
GeneOntologyBiologicalProcesspositive regulation of purine nucleotide catabolic process

MTOR RPTOR

1.74e-0329442GO:0033123
GeneOntologyBiologicalProcessintracellular monoatomic cation homeostasis

TRPC7 SLC4A8 CLCN3 KCNH1 SCARA5 TRPC6

1.79e-03611446GO:0030003
GeneOntologyBiologicalProcessglucose metabolic process

RGPD1 RGPD4 RGPD8 RGPD3

1.79e-03244444GO:0006006
GeneOntologyBiologicalProcessresponse to osmotic stress

MTOR RPTOR DDX3X

1.80e-03113443GO:0006970
GeneOntologyBiologicalProcessprotein folding

RGPD1 RGPD4 RGPD8 RGPD3

1.84e-03246444GO:0006457
GeneOntologyBiologicalProcessphosphatidylinositol dephosphorylation

MTMR12 MTMR11

1.86e-0330442GO:0046856
GeneOntologyBiologicalProcesspeptidyl-threonine phosphorylation

MTOR RPTOR TRPC6

1.89e-03115443GO:0018107
GeneOntologyBiologicalProcessintracellular monoatomic ion homeostasis

TRPC7 SLC4A8 CLCN3 KCNH1 SCARA5 TRPC6

1.95e-03622446GO:0006873
GeneOntologyBiologicalProcesspositive regulation of mitotic cell cycle phase transition

RRM2 RPTOR DDX3X

1.99e-03117443GO:1901992
GeneOntologyBiologicalProcesspositive regulation of peptidyl-threonine phosphorylation

RPTOR TRPC6

2.12e-0332442GO:0010800
GeneOntologyBiologicalProcessregulation of transcription by RNA polymerase III

MTOR RPTOR

2.12e-0332442GO:0006359
GeneOntologyBiologicalProcessbehavioral response to pain

TRPV1 MTOR

2.12e-0332442GO:0048266
GeneOntologyBiologicalProcessglucose 6-phosphate metabolic process

MTOR RPTOR

2.12e-0332442GO:0051156
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RGPD1 RGPD4 RGPD8 RGPD3

1.19e-098444GO:1990723
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RGPD1 RGPD4 RGPD8 RGPD3

3.55e-0910444GO:0044614
GeneOntologyCellularComponentannulate lamellae

RGPD1 RGPD4 RGPD8 RGPD3

1.68e-0814444GO:0005642
GeneOntologyCellularComponentnuclear pore nuclear basket

RGPD1 RGPD4 RGPD8 RGPD3

5.11e-0818444GO:0044615
GeneOntologyCellularComponentnuclear inclusion body

RGPD1 RGPD4 RGPD8 RGPD3

8.07e-0820444GO:0042405
GeneOntologyCellularComponentSUMO ligase complex

RGPD1 RGPD4 RGPD8 RGPD3

9.95e-0821444GO:0106068
GeneOntologyCellularComponentnuclear envelope

RGPD1 RGPD4 CASC3 TRPC7 RGPD8 RRM2 MTOR KCNH1 RGPD3 RGPD5

1.92e-075604410GO:0005635
GeneOntologyCellularComponentnuclear pore

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

2.23e-06101445GO:0005643
GeneOntologyCellularComponentinclusion body

RGPD1 RGPD4 RGPD8 RGPD3

3.82e-0590444GO:0016234
GeneOntologyCellularComponentTORC1 complex

MTOR RPTOR

6.46e-056442GO:0031931
GeneOntologyCellularComponentnuclear membrane

RGPD1 RGPD4 CASC3 RGPD8 KCNH1 RGPD3

8.57e-05349446GO:0031965
GeneOntologyCellularComponentperinuclear region of cytoplasm

RGPD1 RGPD4 CASC3 YTHDC2 TRPC7 RGPD8 KIF1A KCNH1 RGPD3

1.18e-04934449GO:0048471
GeneOntologyCellularComponentorganelle envelope

RGPD1 RGPD4 CASC3 TRPC7 RGPD8 RRM2 MTOR KCNH1 GFER RGPD3 RGPD5

1.43e-0414354411GO:0031967
GeneOntologyCellularComponentTOR complex

MTOR RPTOR

2.82e-0412442GO:0038201
GeneOntologyCellularComponentdendrite

CASC3 ALS2 TRPV1 SLC4A8 KIF1A MTOR KCNH1 RPTOR

3.71e-04858448GO:0030425
GeneOntologyCellularComponentdendritic tree

CASC3 ALS2 TRPV1 SLC4A8 KIF1A MTOR KCNH1 RPTOR

3.77e-04860448GO:0097447
GeneOntologyCellularComponentcell leading edge

ALS2 DPYSL3 TRPV1 CLCN3 KCNH1 DDX3X

5.93e-04500446GO:0031252
GeneOntologyCellularComponentcell body

ALS2 DPYSL3 TRPV1 SLC4A8 KIF1A MTOR KCNH1 RPTOR

6.30e-04929448GO:0044297
GeneOntologyCellularComponentcytoplasmic stress granule

CASC3 RPTOR DDX3X

1.08e-0396443GO:0010494
GeneOntologyCellularComponentcation channel complex

TRPC7 KCNH1 TRPC6 PKD1L1

1.49e-03235444GO:0034703
GeneOntologyCellularComponentneuronal cell body

ALS2 TRPV1 SLC4A8 KIF1A MTOR KCNH1 RPTOR

1.67e-03835447GO:0043025
GeneOntologyCellularComponentribonucleoprotein granule

CASC3 YTHDC2 RPTOR DDX3X

3.07e-03287444GO:0035770
GeneOntologyCellularComponentsomatodendritic compartment

CASC3 ALS2 TRPV1 SLC4A8 KIF1A MTOR KCNH1 RPTOR

3.70e-031228448GO:0036477
GeneOntologyCellularComponentexocytic vesicle

DPYSL3 SLC4A8 CLCN3 KIF1A

4.52e-03320444GO:0070382
GeneOntologyCellularComponentpostsynapse

ALS2 TRPV1 CLCN3 KIF1A MTOR KCNH1 DROSHA

5.03e-031018447GO:0098794
HumanPhenoFull cheeks

SETD1B CLCN3 KCNH1 IARS1 DDX3X

2.28e-05151135HP:0000293
MousePhenoelevated level of mitotic sister chromatid exchange

RGPD1 RGPD4 RGPD8 RGPD3

7.39e-0816374MP:0003701
MousePhenoabnormal morula morphology

RGPD1 RGPD4 RGPD8 RGPD3

5.96e-0726374MP:0012058
MousePhenodecreased tumor latency

RGPD1 RGPD4 RGPD8 RGPD3

1.08e-0630374MP:0010308
MousePhenofailure of blastocyst formation

RGPD1 RGPD4 RGPD8 RGPD3

1.24e-0631374MP:0012129
MousePhenoabnormal tumor latency

RGPD1 RGPD4 RGPD8 RGPD3

1.82e-0634374MP:0010307
MousePhenoabnormal blastocyst formation

RGPD1 RGPD4 RGPD8 RGPD3

3.20e-0639374MP:0012128
MousePhenoenlarged epididymis

RGPD1 RGPD4 CASC3 RGPD8 RGPD3

5.86e-0699375MP:0004931
MousePhenoabnormal preimplantation embryo morphology

RGPD1 RGPD4 RGPD8 MTOR RPTOR DDX3X RGPD3

7.92e-06283377MP:0014137
MousePhenoaneuploidy

RGPD1 RGPD4 RGPD8 RGPD3

1.95e-0561374MP:0004024
MousePhenoabnormal eye electrophysiology

RGPD1 RGPD4 OAT CLCN3 RGPD8 RGPD3

2.68e-05228376MP:0005551
MousePhenoincreased incidence of tumors by chemical induction

RGPD1 RGPD4 TRPV1 RGPD8 RGPD3

3.27e-05141375MP:0004499
MousePhenoincreased hepatocellular carcinoma incidence

RGPD1 RGPD4 RGPD8 RGPD3

3.36e-0570374MP:0003331
MousePhenoincreased lung carcinoma incidence

RGPD1 RGPD4 RGPD8 RGPD3

5.15e-0578374MP:0008714
MousePhenodecreased susceptibility to diet-induced obesity

RGPD1 RGPD4 TRPV1 RGPD8 RGPD3

5.98e-05160375MP:0005659
MousePhenoabnormal epididymis size

RGPD1 RGPD4 CASC3 RGPD8 RGPD3

7.13e-05166375MP:0004926
MousePhenoabnormal chromosome number

RGPD1 RGPD4 RGPD8 RGPD3

7.55e-0586374MP:0004023
MousePhenoincreased incidence of induced tumors

RGPD1 RGPD4 TRPV1 RGPD8 RGPD3

8.67e-05173375MP:0002021
MousePhenoincreased physiological sensitivity to xenobiotic

RGPD1 RGPD4 ALS2 TRPV1 RGPD8 RGPD3

9.49e-05286376MP:0008873
MousePhenodecreased susceptibility to weight gain

RGPD1 RGPD4 TRPV1 RGPD8 RGPD3

1.22e-04186375MP:0010182
MousePhenoincreased sarcoma incidence

RGPD1 RGPD4 RGPD8 RGPD3

1.47e-04102374MP:0002032
MousePhenoabnormal eye physiology

RGPD1 RGPD4 OAT TRPC7 CLCN3 RGPD8 RGPD3 TRPC6

1.51e-04606378MP:0005253
MousePhenoincreased energy expenditure

RGPD1 RGPD4 TRPV1 RGPD8 RGPD3

1.56e-04196375MP:0004889
MousePhenoincreased lung tumor incidence

RGPD1 RGPD4 RGPD8 RGPD3

1.76e-04107374MP:0008014
MousePhenofailure of blastocyst to hatch from the zona pellucida

RGPD1 RGPD4 RGPD8 RGPD3

1.76e-04107374MP:0003694
MousePhenoincreased respiratory system tumor incidence

RGPD1 RGPD4 RGPD8 RGPD3

1.76e-04107374MP:0010298
MousePhenoincreased liver tumor incidence

RGPD1 RGPD4 RGPD8 RGPD3

2.03e-04111374MP:0008019
MousePhenoincreased hepatobiliary system tumor incidence

RGPD1 RGPD4 RGPD8 RGPD3

2.03e-04111374MP:0010297
MousePhenoabnormal blastocyst hatching

RGPD1 RGPD4 RGPD8 RGPD3

2.18e-04113374MP:0003693
MousePhenoabnormal rod electrophysiology

RGPD1 RGPD4 RGPD8 RGPD3

2.65e-04119374MP:0004021
MousePhenoabnormal chromosome morphology

RGPD1 RGPD4 RGPD8 RGPD3

3.30e-04126374MP:0003702
MousePhenoabnormal mitosis

RGPD1 RGPD4 RGPD8 RGPD3

3.51e-04128374MP:0004046
MousePhenoabnormal incidence of induced tumors

RGPD1 RGPD4 TRPV1 RGPD8 RGPD3

6.69e-04269375MP:0013151
MousePhenoabnormal epididymis morphology

RGPD1 RGPD4 CASC3 RGPD8 RGPD3

6.69e-04269375MP:0002631
MousePhenoembryonic lethality prior to organogenesis, complete penetrance

RGPD1 RGPD4 CASC3 RGPD8 MTOR RPTOR DDX3X RGPD3

7.71e-04772378MP:0014259
MousePhenoembryonic lethality prior to tooth bud stage, complete penetrance

RGPD1 RGPD4 CASC3 RGPD8 MTOR RPTOR DDX3X RGPD3

8.18e-04779378MP:0014257
MousePhenoembryonic lethality prior to organogenesis

RGPD1 RGPD4 CASC3 GAPVD1 RGPD8 RRM2 MTOR RPTOR DDX3X RGPD3

8.69e-0412043710MP:0013292
MousePhenoabnormal preimplantation embryo development

RGPD1 RGPD4 RGPD8 RGPD3

1.04e-03171374MP:0009781
MousePhenoabnormal susceptibility to weight gain

RGPD1 RGPD4 TRPV1 RGPD8 RGPD3

1.25e-03309375MP:0011117
MousePhenoabnormal energy expenditure

RGPD1 RGPD4 TRPV1 RGPD8 RGPD3

1.32e-03313375MP:0005450
MousePhenoabnormal cell nucleus morphology

RGPD1 RGPD4 RGPD8 RGPD3

1.37e-03184374MP:0003111
MousePhenoabnormal energy homeostasis

RGPD1 RGPD4 TRPV1 RGPD8 RGPD3

1.50e-03322375MP:0005448
MousePhenoabnormal physiological response to xenobiotic

RGPD1 RGPD4 ALS2 TRPV1 SLC4A8 RGPD8 RGPD3

1.54e-03662377MP:0008872
MousePhenoincreased carcinoma incidence

RGPD1 RGPD4 RGPD8 RGPD3

1.76e-03197374MP:0002038
MousePhenoembryonic lethality before implantation, complete penetrance

RGPD1 RGPD4 RGPD8 RGPD3

1.96e-03203374MP:0011094
MousePhenoabnormal axonal transport

ALS2 DPYSL3

2.30e-0327372MP:0004768
MousePhenoabnormal embryo development

RGPD1 RGPD4 CASC3 GAPVD1 SETD1B RGPD8 MTOR DDX3X RGPD3 PKD1L1

2.33e-0313703710MP:0001672
DomainSpeedy

SPDYE1 SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

7.99e-1711447IPR020984
DomainSpy1

SPDYE1 SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

7.99e-1711447PF11357
DomainGRIP

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

2.62e-1111445PF01465
DomainGrip

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

2.62e-1111445SM00755
DomainRan_BP1

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

4.49e-1112445PF00638
DomainGRIP_dom

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

4.49e-1112445IPR000237
DomainGRIP

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

4.49e-1112445PS50913
DomainRANBD1

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

4.49e-1112445PS50196
DomainRanBD

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

7.28e-1113445SM00160
DomainRan_bind_dom

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

7.28e-1113445IPR000156
DomainGCC2_Rab_bind

RGPD1 RGPD4 RGPD8 RGPD3

9.33e-107444IPR032023
DomainRab_bind

RGPD1 RGPD4 RGPD8 RGPD3

9.33e-107444PF16704
Domain-

RGPD1 RGPD4 RGPD8 RGPD3

5.57e-09104441.10.220.60
DomainPH_dom-like

RGPD1 RGPD4 ALS2 MTMR12 MTMR11 RGPD8 KIF1A RGPD3 RGPD5

5.37e-07426449IPR011993
DomainTRP_channel

TRPV1 TRPC7 TRPC6

1.99e-0611443IPR004729
DomainMTMR12-like_C

MTMR12 MTMR11

1.62e-053442IPR022587
Domain3-PAP

MTMR12 MTMR11

1.62e-053442PF12578
DomainTPR-like_helical_dom

RGPD1 RGPD4 RGPD8 MTOR RGPD3 RGPD5

1.68e-05233446IPR011990
DomainTPR-contain_dom

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

2.64e-05150445IPR013026
Domain-

RGPD1 RGPD4 ALS2 MTMR12 RGPD8 KIF1A RGPD3

3.28e-053914472.30.29.30
DomainTPR

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

4.16e-05165445PS50005
DomainTPR_REGION

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

4.16e-05165445PS50293
DomainTRP_dom

TRPC7 TRPC6

8.09e-056442IPR013555
DomainTRP_2

TRPC7 TRPC6

8.09e-056442PF08344
DomainTRPC_channel

TRPC7 TRPC6

1.13e-047442IPR002153
Domain-

RGPD1 RGPD4 RGPD8 MTOR RGPD3

1.22e-042074451.25.40.10
DomainIon_trans_dom

TRPV1 TRPC7 KCNH1 TRPC6

1.48e-04114444IPR005821
DomainIon_trans

TRPV1 TRPC7 KCNH1 TRPC6

1.48e-04114444PF00520
DomainTPR

RGPD1 RGPD4 RGPD8 RGPD3

2.38e-04129444SM00028
DomainVPS9

ALS2 GAPVD1

2.41e-0410442PS51205
DomainVPS9

ALS2 GAPVD1

2.41e-0410442PF02204
DomainVPS9

ALS2 GAPVD1

2.41e-0410442IPR003123
DomainTPR_repeat

RGPD1 RGPD4 RGPD8 RGPD3

2.68e-04133444IPR019734
DomainPPASE_MYOTUBULARIN

MTMR12 MTMR11

4.85e-0414442PS51339
DomainMyotubularin_fam

MTMR12 MTMR11

4.85e-0414442IPR030564
DomainMyotub-related

MTMR12 MTMR11

4.85e-0414442PF06602
DomainMyotubularin-like_Pase_dom

MTMR12 MTMR11

4.85e-0414442IPR010569
DomainTPR_1

RGPD1 RGPD8 RGPD5

1.24e-0390443PF00515
DomainTPR_1

RGPD1 RGPD8 RGPD5

1.24e-0390443IPR001440
DomainFHA

CEP170 KIF1A

1.97e-0328442SM00240
DomainFHA_DOMAIN

CEP170 KIF1A

2.42e-0331442PS50006
DomainFHA

CEP170 KIF1A

2.42e-0331442PF00498
Domain-

YTHDC2 TRPV1 TRPC7 TRPC6

2.72e-032484441.25.40.20
DomainANK

YTHDC2 TRPV1 TRPC7 TRPC6

2.84e-03251444SM00248
DomainANK_REPEAT

YTHDC2 TRPV1 TRPC7 TRPC6

2.92e-03253444PS50088
DomainAnkyrin_rpt-contain_dom

YTHDC2 TRPV1 TRPC7 TRPC6

2.96e-03254444IPR020683
DomainANK_REP_REGION

YTHDC2 TRPV1 TRPC7 TRPC6

2.96e-03254444PS50297
DomainFHA_dom

CEP170 KIF1A

3.25e-0336442IPR000253
DomainGPS

ADGRF4 PKD1L1

3.25e-0336442PS50221
Domain-

CEP170 KIF1A

3.25e-03364422.60.200.20
DomainAnkyrin_rpt

YTHDC2 TRPV1 TRPC7 TRPC6

3.31e-03262444IPR002110
DomainGPS

ADGRF4 PKD1L1

3.43e-0337442IPR000203
DomainSMAD_FHA_domain

CEP170 KIF1A

6.67e-0352442IPR008984
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

RGPD1 RGPD4 RGPD8 MTOR RPTOR RGPD3

5.18e-0892326MM14951
PathwayBIOCARTA_RANBP2_PATHWAY

RGPD1 RGPD4 RGPD8 RGPD3

6.54e-0818324MM1549
PathwayREACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

RGPD1 RGPD4 CASC3 RGPD8 RGPD3

1.33e-0686325MM15413
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

RGPD1 RGPD4 RGPD8 RGPD3

1.89e-0640324MM14945
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

RGPD1 RGPD4 RGPD8 RGPD3

2.09e-0641324MM15200
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

RGPD1 RGPD4 RGPD8 RGPD3

2.30e-0642324MM15039
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

RGPD1 RGPD4 RGPD8 RGPD3

2.54e-0643324MM14609
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

RGPD1 RGPD4 RGPD8 RGPD3

3.64e-0647324MM14939
PathwayREACTOME_GENE_SILENCING_BY_RNA

RGPD1 RGPD4 RGPD8 RGPD3

4.31e-0649324MM14837
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

RGPD1 RGPD4 RGPD8 RGPD3

4.68e-0650324MM14610
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

RGPD1 RGPD4 RGPD8 RGPD3

5.07e-0651324MM15151
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

RGPD1 RGPD4 RGPD8 RGPD3

6.88e-0655324MM14917
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

RGPD1 RGPD4 RGPD8 RGPD3

8.51e-0658324MM15149
PathwayREACTOME_SNRNP_ASSEMBLY

RGPD1 RGPD4 RGPD8 RGPD3

8.51e-0658324MM14736
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

RGPD1 RGPD4 RGPD8 RGPD3

1.34e-0565324MM15147
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

RGPD1 RGPD4 RGPD8 RGPD3

2.13e-0573324MM14948
PathwayREACTOME_TRP_CHANNELS

TRPV1 TRPC7 TRPC6

3.35e-0528323MM14943
PathwayREACTOME_TRP_CHANNELS

TRPV1 TRPC7 TRPC6

3.35e-0528323M27241
PathwayREACTOME_GLUCOSE_METABOLISM

RGPD1 RGPD4 RGPD8 RGPD3

3.38e-0582324MM15394
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

RGPD1 RGPD4 RGPD8 RGPD3

3.71e-0584324MM14929
PathwayREACTOME_AMPLIFICATION_OF_SIGNAL_FROM_THE_KINETOCHORES

RGPD1 RGPD4 RGPD8 RGPD3

7.36e-05100324MM14561
PathwayREACTOME_STIMULI_SENSING_CHANNELS

TRPV1 TRPC7 CLCN3 TRPC6

9.23e-05106324M27200
PathwayREACTOME_MITOTIC_PROPHASE

RGPD1 RGPD4 RGPD8 RGPD3

1.22e-04114324MM15361
PathwayREACTOME_MITOTIC_SPINDLE_CHECKPOINT

RGPD1 RGPD4 RGPD8 RGPD3

1.35e-04117324MM15387
PathwayREACTOME_RESOLUTION_OF_SISTER_CHROMATID_COHESION

RGPD1 RGPD4 RGPD8 RGPD3

1.97e-04129324MM14894
PathwayREACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN_1_SIGNALING

TRPC7 TRPC6

2.22e-0410322M27330
PathwayKEGG_MEDICUS_REFERENCE_TSC1_2_MTORC1_SIGNALING_PATHWAY

MTOR RPTOR

2.71e-0411322M47915
PathwayREACTOME_RHO_GTPASES_ACTIVATE_FORMINS

RGPD1 RGPD4 RGPD8 RGPD3

2.77e-04141324MM15266
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

RGPD1 RGPD4 CASC3 RGPD8 RGPD3

3.68e-04277325MM15414
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

TRPC7 TRPC6

3.83e-0413322MM14553
PathwayKEGG_MEDICUS_REFERENCE_FLCN_MTORC1_SIGNALING_PATHWAY

MTOR RPTOR

4.47e-0414322M47922
PathwayKEGG_MEDICUS_REFERENCE_GATOR1_MTORC1_SIGNALING_PATHWAY

MTOR RPTOR

4.47e-0414322M47918
PathwayREACTOME_SUMOYLATION

RGPD1 RGPD4 RGPD8 RGPD3

5.52e-04169324MM14919
PathwayKEGG_MEDICUS_REFERENCE_AUTOPHAGY_VESICLE_NUCLEATION_ELONGATION_MATURATION_MTORC1_PI3KC3_C1

MTOR RPTOR

5.87e-0416322M47457
PathwayREACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS

TRPC7 TRPC6

5.87e-0416322M26945
PathwayREACTOME_ION_CHANNEL_TRANSPORT

TRPV1 TRPC7 CLCN3 TRPC6

7.44e-04183324M997
PathwayREACTOME_CELLULAR_RESPONSES_TO_STIMULI

RGPD1 RGPD4 RGPD8 MTOR RPTOR RGPD3

8.40e-04505326MM15548
PathwayREACTOME_SEPARATION_OF_SISTER_CHROMATIDS

RGPD1 RGPD4 RGPD8 RGPD3

9.07e-04193324MM14890
PathwayREACTOME_MITOTIC_PROMETAPHASE

RGPD1 RGPD4 RGPD8 RGPD3

1.07e-03202324MM15362
PathwayREACTOME_HSF1_DEPENDENT_TRANSACTIVATION

MTOR RPTOR

1.23e-0323322MM14953
PathwayREACTOME_MTORC1_MEDIATED_SIGNALLING

MTOR RPTOR

1.34e-0324322M3492
PathwayREACTOME_STIMULI_SENSING_CHANNELS

TRPV1 TRPC7 TRPC6

1.44e-0399323MM14910
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

TRPC7 TRPC6

1.45e-0325322MM14511
PathwayREACTOME_MTORC1_MEDIATED_SIGNALLING

MTOR RPTOR

1.45e-0325322MM14650
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

RGPD1 RGPD4 CASC3 SETD1B RGPD8 MTOR RPTOR RGPD3

1.63e-031022328MM15436
PathwayREACTOME_EFFECTS_OF_PIP2_HYDROLYSIS

TRPC7 TRPC6

1.69e-0327322M12123
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

TRPC7 TRPC6

1.69e-0327322MM15053
PathwayREACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION

MTOR RPTOR

1.69e-0327322MM15537
PathwayREACTOME_PLATELET_CALCIUM_HOMEOSTASIS

TRPC7 TRPC6

1.82e-0328322M924
PathwayREACTOME_MITOTIC_METAPHASE_AND_ANAPHASE

RGPD1 RGPD4 RGPD8 RGPD3

1.85e-03234324MM14898
PathwayREACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK

MTOR RPTOR

1.95e-0329322M19861
PathwayREACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK

MTOR RPTOR

1.95e-0329322MM14980
PathwayWP_AUTOPHAGY

MTOR RPTOR

2.09e-0330322M39904
PathwayWP_PI3KAKTMTOR_SIGNALING_AND_THERAPEUTIC_OPPORTUNITIES_IN_PROSTATE_CANCER

MTOR RPTOR

2.37e-0332322M39445
PathwayWP_BDNFTRKB_SIGNALING

MTOR TRPC6

2.52e-0333322M39532
PathwayWP_CAMKK2_PATHWAY

MTOR RPTOR

2.52e-0333322M40047
PathwayREACTOME_RHO_GTPASE_EFFECTORS

RGPD1 RGPD4 RGPD8 RGPD3

2.60e-03257324MM14755
PathwayWP_JAKSTAT_SIGNALING_IN_THE_REGULATION_OF_BETA_CELLS

MTOR RPTOR

2.68e-0334322M48081
PathwayWP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING

MTOR RPTOR

3.00e-0336322M39569
PathwayWP_TARGET_OF_RAPAMYCIN_SIGNALING

MTOR RPTOR

3.00e-0336322M39635
PathwayREACTOME_CELL_CYCLE_CHECKPOINTS

RGPD1 RGPD4 RGPD8 RGPD3

3.14e-03271324MM15388
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

RGPD1 RGPD4 RGPD8 RGPD3

3.14e-03271324MM15406
PathwayREACTOME_HSF1_DEPENDENT_TRANSACTIVATION

MTOR RPTOR

3.33e-0338322M27255
PathwayWP_CATABOLISM_OF_SKELETAL_MUSCLE_IN_CACHEXIA

MTOR RPTOR

3.69e-0340322M48337
PathwayREACTOME_MTOR_SIGNALLING

MTOR RPTOR

3.87e-0341322M27000
PathwayREACTOME_MTOR_SIGNALLING

MTOR RPTOR

4.06e-0342322MM14638
PathwayWP_NEURODEGENERATION_WITH_BRAIN_IRON_ACCUMULATION_NBIA_SUBTYPES_PATHWAY

MTOR RPTOR

4.45e-0344322M39602
PathwayWP_PERTURBATIONS_TO_HOSTCELL_AUTOPHAGY_INDUCED_BY_SARSCOV2_PROTEINS

MTOR RPTOR

4.45e-0344322M46452
PathwayREACTOME_NETRIN_1_SIGNALING

TRPC7 TRPC6

4.45e-0344322M875
PathwayWP_TRANSLATION_INHIBITORS_IN_CHRONICALLY_ACTIVATED_PDGFRA_CELLS

MTOR RPTOR

4.85e-0346322M39805
PathwayPID_LKB1_PATHWAY

MTOR RPTOR

5.06e-0347322M87
PathwayWP_PHOSPHOINOSITIDES_METABOLISM

MTMR12 MTMR11

5.49e-0349322M40046
PathwayWP_SMITHMAGENIS_AND_POTOCKILUPSKI_SYNDROME_COPY_NUMBER_VARIATION

GID4 MTOR RPTOR

5.49e-03159323M48090
PathwayWP_SYNAPTIC_SIGNALING_ASSOCIATED_WITH_AUTISM_SPECTRUM_DISORDER

MTOR RPTOR

5.71e-0350322M39822
PathwayKEGG_MTOR_SIGNALING_PATHWAY

MTOR RPTOR

6.17e-0352322M7561
PathwayWP_INTERFERON_TYPE_I_SIGNALING

MTOR RPTOR

6.64e-0354322M39435
PathwayREACTOME_AMINO_ACIDS_REGULATE_MTORC1

MTOR RPTOR

6.88e-0355322M29825
PathwayREACTOME_AMINO_ACIDS_REGULATE_MTORC1

MTOR RPTOR

7.12e-0356322MM15667
PathwayREACTOME_ION_CHANNEL_TRANSPORT

TRPV1 TRPC7 TRPC6

7.27e-03176323MM15718
PathwayREACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION

MTOR RPTOR

8.40e-0361322M27811
PathwayWP_DYRK1A_INVOLVEMENT_REGARDING_CELL_PROLIFERATION_IN_BRAIN_DEVELOPMENT

MTOR RPTOR

8.67e-0362322M45532
Pubmed

Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

3.66e-16947636272447
Pubmed

Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

7.45e-151347615611625
Pubmed

Characterization of a new family of cyclin-dependent kinase activators.

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

5.35e-141747615574121
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

7.58e-14747515710750
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD1 RGPD4 RGPD8 RGPD3

1.02e-10747421205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD1 RGPD4 RGPD8 RGPD3

1.02e-10747418949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD1 RGPD4 RGPD8 RGPD3

1.02e-10747425187515
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD1 RGPD4 RGPD8 RGPD3

1.02e-1074749037092
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD1 RGPD4 RGPD8 RGPD3

1.02e-1074748603673
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD1 RGPD4 RGPD8 RGPD3

1.02e-10747426632511
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD1 RGPD4 RGPD8 RGPD3

1.02e-10747424403063
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD1 RGPD4 RGPD8 RGPD3

1.02e-10747423818861
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD1 RGPD4 RGPD8 RGPD3

1.02e-10747411353387
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RGPD1 RGPD4 RGPD8 RGPD3

1.02e-10747430944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RGPD1 RGPD4 RGPD8 RGPD3

1.02e-10747438838144
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RGPD1 RGPD4 RGPD8 RGPD3

1.02e-10747423536549
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RGPD1 RGPD4 RGPD8 RGPD3

1.02e-1074747559465
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RGPD1 RGPD4 RGPD8 RGPD3

1.02e-10747417372272
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RGPD1 RGPD4 RGPD8 RGPD3

1.02e-10747438657106
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RGPD1 RGPD4 RGPD8 RGPD3

1.02e-10747412191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RGPD1 RGPD4 RGPD8 RGPD3

1.02e-10747422821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RGPD1 RGPD4 RGPD8 RGPD3

1.02e-10747420682751
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RGPD1 RGPD4 RGPD8 RGPD3

2.04e-10847422262462
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RGPD1 RGPD4 RGPD8 RGPD3

2.04e-10847421670213
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RGPD1 RGPD4 RGPD8 RGPD3

2.04e-10847428745977
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RGPD1 RGPD4 RGPD8 RGPD3

2.04e-10847427412403
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RGPD1 RGPD4 RGPD8 RGPD3

2.04e-10847421310149
Pubmed

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

RGPD1 RGPD4 RGPD8 RGPD3

3.67e-10947418394993
Pubmed

The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.

RGPD1 RGPD4 RGPD8 RGPD3

3.67e-10947411553612
Pubmed

The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.

RGPD1 RGPD4 RGPD8 RGPD3

3.67e-10947410601307
Pubmed

The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.

RGPD1 RGPD4 RGPD8 RGPD3

3.67e-1094749733766
Pubmed

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

RGPD1 RGPD4 RGPD8 RGPD3

3.67e-10947428100513
Pubmed

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.

RGPD1 RGPD4 RGPD8 RGPD3

3.67e-10947428877029
Pubmed

Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

RGPD1 RGPD4 RGPD8 RGPD3

3.67e-10947417887960
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

RGPD1 RGPD4 RGPD8 RGPD3

6.11e-10104748857542
Pubmed

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

RGPD1 RGPD4 RGPD8 RGPD3

6.11e-101047427160050
Pubmed

Parkin ubiquitinates and promotes the degradation of RanBP2.

RGPD1 RGPD4 RGPD8 RGPD3

6.11e-101047416332688
Pubmed

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

RGPD1 RGPD4 RGPD8 RGPD3

6.11e-101047421859863
Pubmed

An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.

RGPD1 RGPD4 RGPD8 RGPD3

9.59e-101147435771867
Pubmed

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

RGPD1 RGPD4 RGPD8 RGPD3

9.59e-101147417069463
Pubmed

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.

RGPD1 RGPD4 RGPD8 RGPD3

9.59e-101147434110283
Pubmed

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.

RGPD1 RGPD4 RGPD8 RGPD3

2.07e-091347431427429
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

RGPD1 RGPD4 RGPD8 RGPD3

3.95e-091547414697343
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

RGPD1 RGPD4 RGPD8 MTOR RPTOR RGPD3 RGPD5

1.60e-0821547735973513
Pubmed

Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.

RGPD1 RGPD4 RGPD8 RGPD3

2.10e-082247427717094
Pubmed

A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.

TRPV1 TRPC7 TRPC6 PKD1L1

1.16e-073347419834762
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

CEP170 CASC3 ALS2 DPYSL3 MTMR12 GAPVD1 RRM2 MTOR RPTOR DDX3X

1.86e-07861471036931259
Pubmed

Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion.

TRPV1 TRPC7 TRPC6

1.93e-07947317480026
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

RGPD1 RGPD4 RGPD8 RGPD3

2.09e-073847412791264
Pubmed

Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.

MTOR IARS1 RPTOR

2.76e-071047322424946
Pubmed

Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.

TRPV1 TRPC7 TRPC6 PKD1L1

3.82e-074447419322198
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

RGPD1 RGPD4 CEP170 CASC3 SLC4A8 RGPD8 MTOR RPTOR DDX3X RGPD3

5.17e-07963471028671696
Pubmed

Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.

RGPD1 RGPD4 NAA40 RGPD8 RGPD3

1.10e-0613547531077711
Pubmed

mTOR kinase-dependent, but raptor-independent regulation of downstream signaling is important for cell cycle exit and myogenic differentiation.

MTOR RPTOR

1.79e-06247225486193
Pubmed

The mTORC1 component RPTOR is required for maintenance of the foundational spermatogonial stem cell pool in mice†.

MTOR RPTOR

1.79e-06247230202948
Pubmed

Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking.

MTOR RPTOR

1.79e-06247217301289
Pubmed

Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice.

MTOR RPTOR

1.79e-06247218270303
Pubmed

Conditional Knockout of Raptor/mTORC1 Results in Dentin Malformation.

MTOR RPTOR

1.79e-06247230984011
Pubmed

Hepatic peroxisomal β-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation.

MTOR RPTOR

1.79e-06247232687428
Pubmed

Deletion of mTORC1 Activity in CD4+ T Cells Is Associated with Lung Fibrosis and Increased γδ T Cells.

MTOR RPTOR

1.79e-06247227649073
Pubmed

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors.

MTOR RPTOR

1.79e-06247229786082
Pubmed

Molecular determinants for cardiovascular TRPC6 channel regulation by Ca2+/calmodulin-dependent kinase II.

TRPC7 TRPC6

1.79e-06247223529130
Pubmed

Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning.

MTOR RPTOR

1.79e-06247227018708
Pubmed

The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity.

MTOR RPTOR

1.79e-06247216847060
Pubmed

Mitotic raptor promotes mTORC1 activity, G(2)/M cell cycle progression, and internal ribosome entry site-mediated mRNA translation.

MTOR RPTOR

1.79e-06247220439490
Pubmed

PLC-mediated PI(4,5)P2 hydrolysis regulates activation and inactivation of TRPC6/7 channels.

TRPC7 TRPC6

1.79e-06247224470487
Pubmed

Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.

MTMR12 GAPVD1 MTMR11 RRM2 KIF1A

3.13e-0616747525659891
Pubmed

Mapping the expression of transient receptor potential channels across murine placental development.

TRPV1 TRPC7 TRPC6

4.59e-062447333884443
Pubmed

International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.

TRPV1 TRPC7 TRPC6

5.21e-062547316382100
Pubmed

Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells.

MTOR RPTOR

5.36e-06347220233713
Pubmed

Distribution and association of mTOR with its cofactors, raptor and rictor, in cumulus cells and oocytes during meiotic maturation in mice.

MTOR RPTOR

5.36e-06347223440873
Pubmed

Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1.

MTOR RPTOR

5.36e-06347221471201
Pubmed

mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition.

MTOR RPTOR

5.36e-06347225385646
Pubmed

The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in Regulation of mTOR.

MTOR RPTOR

5.36e-06347225657994
Pubmed

Evolution of the Cdk-activator Speedy/RINGO in vertebrates.

SPDYE6 SPDYE2

5.36e-06347222763696
Pubmed

Expression of the mTOR pathway regulators in human pituitary adenomas indicates the clinical course.

MTOR RPTOR

5.36e-06347223898069
Pubmed

mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity.

MTOR RPTOR

5.36e-06347228813526
Pubmed

Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1.

MTOR RPTOR

5.36e-06347212912989
Pubmed

Localization of Rheb to the endomembrane is critical for its signaling function.

MTOR RPTOR

5.36e-06347216631613
Pubmed

Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function.

MTOR RPTOR

5.36e-06347222143799
Pubmed

Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.

MTOR RPTOR

5.36e-06347219724909
Pubmed

mTOR Signaling in Growth, Metabolism, and Disease.

MTOR RPTOR

5.36e-06347228283069
Pubmed

Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase dependent mammalian target of rapamycin raptor complex 1 activation.

MTOR RPTOR

5.36e-06347217656678
Pubmed

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.

MTOR RPTOR

5.36e-06347220008564
Pubmed

Conditional Disruption of Raptor Reveals an Essential Role for mTORC1 in B Cell Development, Survival, and Metabolism.

MTOR RPTOR

5.36e-06347227521345
Pubmed

mTORC1 Signaling is a Critical Regulator of Postnatal Tendon Development.

MTOR RPTOR

5.36e-06347229215029
Pubmed

Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1.

MTOR RPTOR

5.36e-06347218614546
Pubmed

mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 type to M2 type.

MTOR RPTOR

5.36e-06347227342766
Pubmed

Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908.

MTOR RPTOR

5.36e-06347222356909
Pubmed

Parkin ubiquitinates mTOR to regulate mTORC1 activity under mitochondrial stress.

MTOR RPTOR

5.36e-06347225007995
Pubmed

Cutting edge: mTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production.

MTOR RPTOR

5.36e-06347222504639
Pubmed

The human myometrium differentially expresses mTOR signalling components before and during pregnancy: evidence for regulation by progesterone.

MTOR RPTOR

5.36e-06347223541542
Pubmed

Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries.

TRPC7 TRPC6

5.36e-06347228526717
Pubmed

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.

MTOR RPTOR

5.36e-06347212408816
Pubmed

GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling.

MTOR RPTOR

5.36e-06347226348909
Pubmed

mTORC1 directly phosphorylates and activates ERα upon estrogen stimulation.

MTOR RPTOR

5.36e-06347226522726
Pubmed

Increase of microRNA-210, decrease of raptor gene expression and alteration of mammalian target of rapamycin regulated proteins following mithramycin treatment of human erythroid cells.

MTOR RPTOR

5.36e-06347225849663
Pubmed

The Rapamycin-Sensitive Complex of Mammalian Target of Rapamycin Is Essential to Maintain Male Fertility.

MTOR RPTOR

5.36e-06347226683665
Pubmed

Leucine regulates autophagy via acetylation of the mTORC1 component raptor.

MTOR RPTOR

5.36e-06347232561715
Pubmed

Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation.

MTOR RPTOR

5.36e-06347219864431
InteractionRGPD4 interactions

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

8.91e-1022435int:RGPD4
InteractionRGPD2 interactions

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

2.71e-0927435int:RGPD2
InteractionRGPD3 interactions

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

4.99e-0847435int:RGPD3
InteractionRGPD1 interactions

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

6.19e-0849435int:RGPD1
InteractionRGPD8 interactions

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

5.02e-0774435int:RGPD8
InteractionRGPD5 interactions

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

1.84e-0696435int:RGPD5
InteractionFKBP1A interactions

TRPV1 TRPC7 MTOR RPTOR TRPC6

4.12e-06113435int:FKBP1A
InteractionRAN interactions

RGPD1 RGPD4 NAA40 RGPD8 IARS1 RPTOR RGPD3 RGPD5

6.31e-06475438int:RAN
InteractionNPIPB6 interactions

RGPD1 RGPD8 RGPD5

7.22e-0618433int:NPIPB6
InteractionGDI2P1 interactions

MTOR RPTOR

2.66e-054432int:GDI2P1
InteractionBICD2 interactions

RGPD1 DPYSL3 RGPD8 RRM2 DDX3X PKD1L1 RGPD5

3.00e-05426437int:BICD2
InteractionSIRT6 interactions

CEP170 YTHDC2 GAPVD1 SETD1B RGPD8 RRM2 DDX3X RGPD5

4.70e-05628438int:SIRT6
InteractionTRPC7 interactions

TRPC7 TRPC6

6.63e-056432int:TRPC7
InteractionYWHAH interactions

CEP170 CASC3 ALS2 DPYSL3 MTMR12 GAPVD1 RRM2 MTOR RPTOR DDX3X

8.41e-0511024310int:YWHAH
InteractionRANBP2 interactions

RGPD1 RGPD4 NAA40 RGPD8 RGPD3 RGPD5

1.10e-04361436int:RANBP2
InteractionRICTOR interactions

RGPD1 RGPD4 RGPD8 MTOR IARS1 RPTOR RGPD3 RGPD5

1.76e-04759438int:RICTOR
InteractionYWHAG interactions

CEP170 CASC3 ALS2 DPYSL3 MTMR12 GAPVD1 RRM2 MTOR RPTOR DDX3X

2.34e-0412484310int:YWHAG
InteractionBTF3 interactions

RGPD4 CEP170 NAA40 RGPD8 MTOR DDX3X RGPD3 RGPD5

2.49e-04799438int:BTF3
InteractionNUP62 interactions

NAA40 RGPD8 DDX3X RGPD3 RGPD5

2.78e-04273435int:NUP62
Cytoband2q13

RGPD8 RGPD3 RGPD5

4.81e-05684732q13
CytobandEnsembl 112 genes in cytogenetic band chr7q11

SPDYE21 SPDYE5 SPDYE18 SPDYE16

1.73e-04271474chr7q11
Cytoband8p21.1

FBXO16 SCARA5

1.93e-04204728p21.1
Cytoband7q22.1

SPDYE2B SPDYE6 SPDYE2

2.18e-041134737q22.1
Cytoband5p13.3

MTMR12 DROSHA

2.79e-04244725p13.3
CytobandEnsembl 112 genes in cytogenetic band chr7q22

SPDYE2B SPDYE6 SPDYE2

1.49e-03219473chr7q22
CytobandEnsembl 112 genes in cytogenetic band chr2q12

RGPD4 RGPD3

3.23e-0382472chr2q12
Cytoband7q11.23

SPDYE5 SPDYE18

4.49e-03974727q11.23
CytobandEnsembl 112 genes in cytogenetic band chr8p21

FBXO16 SCARA5

8.51e-03135472chr8p21
CytobandEnsembl 112 genes in cytogenetic band chr5p13

MTMR12 DROSHA

9.00e-03139472chr5p13
GeneFamilySpeedy/RINGO cell cycle regulator family

SPDYE1 SPDYE5 SPDYE2B SPDYE6 SPDYE2

8.29e-1212315756
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RGPD1 RGPD4 RGPD8 RGPD3 RGPD5

1.42e-06115315769
GeneFamilyTransient receptor potential cation channels

TRPV1 TRPC7 TRPC6

1.45e-0528313249
GeneFamilyMTOR complex 1|MTOR complex 2

MTOR RPTOR

1.70e-0543121332
GeneFamilyVPS9 domain containing

ALS2 GAPVD1

1.27e-0410312928
GeneFamilyMyotubularins|Phosphoinositide phosphatases

MTMR12 MTMR11

2.95e-0415312903
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP

RGPD1 RGPD4 RGPD8 RGPD3

3.27e-0733464MM477
CoexpressionTABULA_MURIS_SENIS_TRACHEA_GRANULOCYTE_AGEING

RGPD1 RGPD4 RGPD8 RGPD3

9.74e-0743464MM3857
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_CORRELATED_WITH_HAI_28DY_RESPONSE_AT_7DY_NEGATIVE

RGPD1 RGPD4 FBXO16 YTHDC2 RGPD8 DDX3X RGPD3 RGPD5

1.54e-06474468M40991
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPYSL3 CENPVL3 SLC4A8 KIF1A

4.38e-05190464bdbfaced785db79ff965f332759be258dbf743cf
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DPYSL3 CENPVL3 SLC4A8 KIF1A

4.65e-051934648851275bcf4ecd6e87a91c8784fc5d76d246ff3b
ToppCellmLN-B_cell-B_cell_cycling|mLN / Region, Cell class and subclass

CASC3 AUNIP RRM2 DROSHA

5.04e-05197464806dddcca85c82bd642008d930c8db16b613d88e
ToppCellmLN-(2)_B_cell-(24)_B_cell_cycling|mLN / shred on region, Cell_type, and subtype

CASC3 AUNIP RRM2 DROSHA

5.04e-0519746470fff2d6723f259e18e7a21d22dc46d71f0759ce
ToppCellmLN-B_cell-B_cell_cycling|B_cell / Region, Cell class and subclass

CASC3 AUNIP RRM2 DROSHA

5.04e-051974642071526fe46de8359ea118ff78581eb4454aa55a
ToppCellnucseq-Mesenchymal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DPYSL3 CCDC102B SCARA5 TRPC6

5.14e-051984648f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCellParenchymal-NucSeq-Stromal-Pericyte-Muscle_pericyte_systemic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CCDC102B KCNH1 SPDYE6 TRPC6

5.14e-05198464882710bd6215e299257dd3df234292db9a2823ba
ToppCellAdult-Mesenchymal|Adult / Lineage, Cell type, age group and donor

DPYSL3 CCDC102B SCARA5 TRPC6

5.14e-0519846426e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCellSigmoid-T_cell-Tcm|T_cell / Region, Cell class and subclass

CCDC102B RGPD8 MTOR RGPD3

5.24e-05199464acdf95f4d58df47690f4ae254245bc618f9ac07e
ToppCellBronchial-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DPYSL3 CCDC102B SCARA5 TRPC6

5.34e-05200464cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCellBronchial-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DPYSL3 CCDC102B SCARA5 TRPC6

5.34e-05200464389cc775c8419d90fb77cd794376d2160a7bf44e
Drug1-oleoyl-2-acetylglycerol

TRPV1 TRPC7 TRPC6

2.81e-0615433ctd:C038237
Diseasenicotine dependence (implicated_via_orthology)

TRPC7 TRPC6

1.11e-0412392DOID:0050742 (implicated_via_orthology)
Diseasebody surface area

RGPD1 MTMR11 RRM2 KIF1A MTOR RPTOR

1.85e-04643396EFO_0022196
Diseaseacute kidney failure (implicated_via_orthology)

MTOR GFER

5.85e-0427392DOID:3021 (implicated_via_orthology)
DiseaseNEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE

GAPVD1 TRPC6

7.23e-0430392C1868672
Diseaseornithine measurement

OAT DPYSL3

1.55e-0344392EFO_0009776
Diseaseureteral obstruction (biomarker_via_orthology)

MTOR GFER

1.63e-0345392DOID:5199 (biomarker_via_orthology)
DiseasePrecursor T-Cell Lymphoblastic Leukemia-Lymphoma

MTOR DDX3X

2.25e-0353392C1961099
Diseasehair morphology measurement

CCDC102B RPTOR

2.33e-0354392EFO_0007821
Diseaseobsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa

NAA40 GID4 RPTOR

2.34e-03200393EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351
Diseasemyocardial infarction (implicated_via_orthology)

TRPV1 MTOR

3.46e-0366392DOID:5844 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
SWWGDDEVDEKRAFK

CEP170

181

Q5SW79
EKWKAVFDECWRQLG

ALS2

1291

Q96Q42
EKWREWADGKSCCDY

DPYSL3

121

Q14195
GWHSKKRRWDEKACQ

ADGRF4

351

Q8IZF3
WVWTACDFADGERKV

RGPD5

1426

Q99666
WVWTACDFADGERKV

RGPD8

1426

O14715
RWCDKSDEDDWSKPL

DDX3X

126

O00571
DWETERKKQAARGWR

MTMR11

201

A4FU01
DTLKDWCWELERTKG

MTMR12

206

Q9C0I1
SDDEKSDRNRPWWRK

GAPVD1

966

Q14C86
SWARFKDACGKSEDW

KCNH1

836

O95259
WDICEAWAEKRGYKT

GNL1

476

P36915
EQSEWGWKDREKREE

NAA40

86

Q86UY6
WDADEDVDRKHWGKF

GID4

191

Q8IVV7
VWVWTACDFADGERK

RGPD3

1426

A6NKT7
LWKDEGRWEHDKFRE

CASC3

211

O15234
ERWETFRKLWGLSCE

CENPVL3

101

A0A0U1RRI6
EERRALLGKWFDKWT

FBXO16

36

Q8IX29
DRRWGTVCDDGWDKK

SCARA5

411

Q6ZMJ2
SDCTANWREKWSKVR

CCDC102B

96

Q68D86
CLFWDKREWKSERFS

PKD1L1

1691

Q8TDX9
DRKEEKGDSARKWEW

AUNIP

186

Q9H7T9
ERECELALWAFRKWK

KIF1A

701

Q12756
WVWTACDFADGERKV

RGPD1

1411

P0DJD0
QKAWGAARRVSKDDW

MTOR

1266

P42345
VWVWTACDFADGERK

RGPD4

1426

Q7Z3J3
KRARWEEEKDRWSDN

DROSHA

361

Q9NRR4
EVVAFRAFDEWWDKK

SETD1B

886

Q9UPS6
REKRFGNWLKDARDW

IARS1

441

P41252
KEGEDAEWKETARWL

SLC4A8

126

Q2Y0W8
AEWKETARWLKFEED

SLC4A8

131

Q2Y0W8
LGWKRKREWSDESEE

SPDYE2B

66

A6NHP3
KDWDAWKVCLRLRDN

OAT

386

P04181
ADKDSICFWDWEKGE

RPTOR

1041

Q8N122
FDCSKVDERWRDGWK

GFER

186

P55789
FEERDKCPQWKTWAE

CLCN3

181

P51790
KDDYRWCFRVDEVNW

TRPV1

736

Q8NER1
KADWALRWIGDKEAT

RRM2

206

P31350
WKRKREWWDESEESL

SPDYE16

101

A6NNV3
WKRKREWWDESEESL

SPDYE18

141

P0DV79
WKRKREWWDESEESL

SPDYE21

141

A0A494C086
LGWKRKREWSDESEE

SPDYE2

66

Q495Y8
LGWKRKREWSDESAE

SPDYE5

66

A6NIY4
LGWKRKREWSDESEE

SPDYE6

66

P0CI01
LGWKRKREWSDESEE

SPDYE1

26

Q8NFV5
AWQKARSDGWERAFC

YTHDC2

906

Q9H6S0
WKRKREWWDESEESL

nan

101

A6NJR5
DDADVEWKFARAKLW

TRPC6

736

Q9Y210
EDADVEWKFARAKLW

TRPC7

681

Q9HCX4