Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	methylated histone binding	SPIN2A SPIN2B SPIN1 SPIN3	2.88e-05	86	41	4	GO:0035064
GeneOntologyMolecularFunction	methylation-dependent protein binding	SPIN2A SPIN2B SPIN1 SPIN3	3.15e-05	88	41	4	GO:0140034
GeneOntologyMolecularFunction	modification-dependent protein binding	SPIN2A ANK2 SPIN2B SPIN1 SPIN3	6.17e-05	206	41	5	GO:0140030
GeneOntologyMolecularFunction	protein tyrosine/serine/threonine phosphatase activity	CDC14C CDC14B CDC14A	9.37e-05	43	41	3	GO:0008138
GeneOntologyMolecularFunction	histone binding	SPIN2A SPIN2B SUPT6H SPIN1 SPIN3	2.01e-04	265	41	5	GO:0042393
GeneOntologyMolecularFunction	myosin phosphatase activity	CDC14C CDC14B CDC14A	7.06e-04	85	41	3	GO:0017018
GeneOntologyMolecularFunction	semaphorin receptor binding	SEMA4D SEMA6D	1.01e-03	23	41	2	GO:0030215
GeneOntologyMolecularFunction	protein tyrosine phosphatase activity	CDC14C CDC14B CDC14A	1.23e-03	103	41	3	GO:0004725
GeneOntologyMolecularFunction	protein serine/threonine phosphatase activity	CDC14C CDC14B CDC14A	1.45e-03	109	41	3	GO:0004722
GeneOntologyMolecularFunction	chemorepellent activity	SEMA4D SEMA6D	1.61e-03	29	41	2	GO:0045499
GeneOntologyBiologicalProcess	regulation of exit from mitosis	CDC14C CDC14B CDC14A	1.35e-05	23	42	3	GO:0007096
GeneOntologyBiologicalProcess	exit from mitosis	CDC14C CDC14B CDC14A	5.81e-05	37	42	3	GO:0010458
Domain	Spin-Ssty	SPIN2A SPIN2B SPIN1 SPIN3	1.10e-10	5	42	4	PF02513
Domain	SPIN/Ssty	SPIN2A SPIN2B SPIN1 SPIN3	1.10e-10	5	42	4	IPR003671
Domain	SPIN-2	SPIN2A SPIN2B	4.94e-06	2	42	2	IPR029564
Domain	DSPn	CDC14B CDC14A	4.94e-06	2	42	2	PF14671
Domain	DSPn	CDC14B CDC14A	4.94e-06	2	42	2	IPR029260
Domain	EF-hand-dom_pair	PKD2L1 CCAR2 PPP2R3A EFCAB6 SPEF2	4.42e-04	287	42	5	IPR011992
Domain	Semaphorin	SEMA4D SEMA6D	9.14e-04	20	42	2	IPR027231
Domain	SEMA	SEMA4D SEMA6D	2.20e-03	31	42	2	PS51004
Domain	Sema	SEMA4D SEMA6D	2.20e-03	31	42	2	SM00630
Domain	Semap_dom	SEMA4D SEMA6D	2.20e-03	31	42	2	IPR001627
Domain	Sema	SEMA4D SEMA6D	2.20e-03	31	42	2	PF01403
Domain	Plexin_repeat	SEMA4D SEMA6D	2.35e-03	32	42	2	IPR002165
Domain	PSI	SEMA4D SEMA6D	2.35e-03	32	42	2	PF01437
Domain	TYR_PHOSPHATASE_DUAL	CDC14B CDC14A	2.65e-03	34	42	2	PS50054
Domain	DSPc	CDC14B CDC14A	2.80e-03	35	42	2	SM00195
Domain	TYR_PHOSPHATASE_DUAL_dom	CDC14B CDC14A	2.80e-03	35	42	2	IPR020422
Domain	PTPase_domain	CDC14B CDC14A	3.83e-03	41	42	2	IPR000242
Domain	Dual-sp_phosphatase_cat-dom	CDC14B CDC14A	3.83e-03	41	42	2	IPR000340
Domain	Y_phosphatase	CDC14B CDC14A	3.83e-03	41	42	2	PF00102
Domain	DSPc	CDC14B CDC14A	3.83e-03	41	42	2	PF00782
Domain	PSI	SEMA4D SEMA6D	4.40e-03	44	42	2	IPR016201
Domain	PSI	SEMA4D SEMA6D	4.80e-03	46	42	2	SM00423
Domain	PTPc_motif	CDC14B CDC14A	7.79e-03	59	42	2	SM00404
Domain	Tyr_Pase_cat	CDC14B CDC14A	7.79e-03	59	42	2	IPR003595
Pubmed	A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1.	SPIN2A SPIN2B SPIN1 SPIN3	3.03e-11	6	43	4	29061846
Pubmed	Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.	CDC14C CDC14B CDC14A	1.76e-09	3	43	3	26283732
Pubmed	CDC14A phosphatase is essential for hearing and male fertility in mouse and human.	CDC14C CDC14B CDC14A	7.04e-09	4	43	3	29293958
Pubmed	Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair.	CDC14B CDC14A	1.49e-06	2	43	2	20479464
Pubmed	Overexpression of CDC14B causes mitotic arrest and inhibits zygotic genome activation in mouse preimplantation embryos.	CDC14C CDC14B	1.49e-06	2	43	2	19923902
Pubmed	The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway.	CDC14C CDC14B	1.49e-06	2	43	2	21502810
Pubmed	Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation.	CDC14B CDC14A	1.49e-06	2	43	2	11901424
Pubmed	Cdc14: a highly conserved family of phosphatases with non-conserved functions?	CDC14C CDC14A	1.49e-06	2	43	2	20720150
Pubmed	Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression.	SPIN2A SPIN2B	1.49e-06	2	43	2	12145692
Pubmed	Human cells lacking CDC14A and CDC14B show differences in ciliogenesis but not in mitotic progression.	CDC14B CDC14A	1.49e-06	2	43	2	33328327
Pubmed	Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase.	CDC14B CDC14A	1.49e-06	2	43	2	12134069
Pubmed	Birth and rapid subcellular adaptation of a hominoid-specific CDC14 protein.	CDC14C CDC14B	1.49e-06	2	43	2	18547142
Pubmed	Functional homology among human and fission yeast Cdc14 phosphatases.	CDC14B CDC14A	1.49e-06	2	43	2	15911625
Pubmed	Early-onset aging and defective DNA damage response in Cdc14b-deficient mice.	CDC14C CDC14B	4.48e-06	3	43	2	21262768
Pubmed	A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast.	CDC14B CDC14A	4.48e-06	3	43	2	9367992
Pubmed	Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription.	CDC14C CDC14B	4.48e-06	3	43	2	22355704
Pubmed	CDC14B acts through FZR1 (CDH1) to prevent meiotic maturation of mouse oocytes.	CDC14C CDC14B	4.48e-06	3	43	2	19129509
Pubmed	The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53.	CDC14B CDC14A	4.48e-06	3	43	2	10644693
Pubmed	Altered expression and distribution of cathepsins in neuronopathic forms of Gaucher disease and in other sphingolipidoses.	SMPD1 GLB1	8.94e-06	4	43	2	20616152
Pubmed	Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression.	CDC14B CDC14A	8.94e-06	4	43	2	22784093
Pubmed	Mis12 controls cyclin B1 stabilization via Cdc14B-mediated APC/CCdh1 regulation during meiotic G2/M transition in mouse oocytes.	CDC14C CDC14B	8.94e-06	4	43	2	32341029
Pubmed	Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.	SEMA4D GLB1 CD109	1.44e-05	38	43	3	16263699
Pubmed	C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosis.	CDC14B CDC14A	1.49e-05	5	43	2	20236090
Pubmed	Network organization of the human autophagy system.	CAB39 GABARAP CCAR2 TRAPPC8 UFC1 FREM1	1.56e-05	437	43	6	20562859
Pubmed	Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins.	GABARAP ANK2	5.35e-05	9	43	2	29867141
Pubmed	DBC1 is a negative regulator of SIRT1.	CCAR2 TAF2	6.68e-05	10	43	2	18235501
Pubmed	TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.	GABARAP MEFV	2.52e-04	19	43	2	26347139
Pubmed	Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.	ANK2 CACNA2D3	2.52e-04	19	43	2	24315451
Pubmed	TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.	GABARAP MEFV	2.80e-04	20	43	2	25127057
Pubmed	Noncoding RNA MaIL1 is an integral component of the TLR4-TRIF pathway.	CCAR2 CD109	3.40e-04	22	43	2	32241891
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	CAB39 GABARAP ANK2 SUPT6H DROSHA	3.59e-04	497	43	5	23414517
Pubmed	Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping.	TUBGCP6 EFCAB6	4.05e-04	24	43	2	11258795
Pubmed	Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.	SEMA4D SEMA6D	5.53e-04	28	43	2	18617019
Pubmed	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.	CCAR2 SPIN1	8.17e-04	34	43	2	30894540
Pubmed	DNA sequence and analysis of human chromosome 9.	SEMA4D KIF24 SPIN1 FREM1	1.12e-03	370	43	4	15164053
Pubmed	HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins.	SEMA4D CD109	1.13e-03	40	43	2	25275127
Interaction	DEFB107A interactions	SPIN2B SPIN1 SPIN3	2.55e-06	13	43	3	int:DEFB107A
Interaction	CDY2A interactions	SPIN2A SPIN1 SPIN3	1.17e-05	21	43	3	int:CDY2A
Cytoband	Xp11.1	SPIN2A SPIN2B	5.14e-06	4	43	2	Xp11.1
Cytoband	18q12.1	RNF125 TRAPPC8	2.75e-04	26	43	2	18q12.1
Cytoband	Ensembl 112 genes in cytogenetic band chr9q22	SEMA4D CDC14B SPIN1	8.84e-04	200	43	3	chr9q22
Cytoband	Ensembl 112 genes in cytogenetic band chr18q12	RNF125 TRAPPC8	4.32e-03	104	43	2	chr18q12
Cytoband	Ensembl 112 genes in cytogenetic band chrXp11	SPIN2A SPIN2B SPIN3	5.32e-03	377	43	3	chrXp11
Cytoband	Ensembl 112 genes in cytogenetic band chr5p13	DROSHA SPEF2	7.58e-03	139	43	2	chr5p13
GeneFamily	Tudor domain containing\|Spindlin family	SPIN2A SPIN2B SPIN1 SPIN3	1.97e-11	5	27	4	1089
GeneFamily	Tudor domain containing	SPIN2A SPIN2B SPIN1 SPIN3	2.52e-07	37	27	4	780
GeneFamily	CDC14 phosphatases	CDC14B CDC14A	1.29e-05	4	27	2	900
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA4D SEMA6D	4.01e-04	20	27	2	736
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PKD2L1 SEMA4D TRAPPC8 CACNA2D3	1.97e-05	166	43	4	3b67064a5149e72f895344d938c64b8ff65247f5
ToppCell	368C-Fibroblasts-Fibroblast-C_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	U2AF1L4 MSH3 BUB1 CD109	2.07e-05	168	43	4	c66a61d3ec711796313a2c6d2dc39aedbfc20afd
ToppCell	368C-Fibroblasts-Fibroblast-C_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	U2AF1L4 MSH3 BUB1 CD109	2.07e-05	168	43	4	83b4f817d95daa15ae60668e789f97d8a3b2e6dd
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PPP2R3A SEMA6D ANK2 CACNA2D3	2.71e-05	180	43	4	9e09b3dfe344b5d50520711513d389865d73a861
ToppCell	ILEUM-inflamed-(1)_T_cell-(1)_CD8_Trm\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	GPR155 MSH3 RNF125 CDC14A	2.95e-05	184	43	4	cef3ee2a4a0af961aa3b4c92150d423e841ae8c1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPP2R3A SEMA6D ANK2 CACNA2D3	3.01e-05	185	43	4	03f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPP2R3A SEMA6D ANK2 CACNA2D3	3.08e-05	186	43	4	1850583d23903d08226aeb0edb3e07b0994330e4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PPP2R3A SEMA6D ANK2 CACNA2D3	3.08e-05	186	43	4	4dafc215c42e7949f932a3627359c107943b5d6b
ToppCell	ILEUM-inflamed-(1)_CD8_Trm\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	GPR155 MSH3 RNF125 CDC14A	3.14e-05	187	43	4	a77d7ae44f47410bd92fb3aa0f44dce891752b63
ToppCell	Fetal_29-31_weeks-Immune-T_lymphocyte\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	GPR155 SEMA4D RNF125 CDC14A	3.48e-05	192	43	4	69a2b04f03a1b82d067018379f7b8a116e954040
ToppCell	ILEUM-non-inflamed-(1)_CD8_Trm\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	GPR155 MSH3 RNF125 CDC14A	3.48e-05	192	43	4	a9f89043c97cd2b0ba165e69ee5681094410af37
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RNF125 CDC14A SPEF2 CD109	3.55e-05	193	43	4	e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA4D PPP2R3A ANK2 CACNA2D3	3.77e-05	196	43	4	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	EFCAB6 KIF24 SPEF2 BUB1	3.85e-05	197	43	4	6e4a411ef823ce9e16f420e185e21fa19d13af34
Drug	lithium indium	SPIN2A SPIN2B	3.48e-06	2	43	2	CID011116062
Drug	scandium phosphate	SPIN2A SPIN2B	3.48e-06	2	43	2	CID006365269
Drug	rubidium nitrate	SPIN2A SPIN2B	3.48e-06	2	43	2	CID000025731
Drug	AC1L5AFV	SMPD1 GLB1	1.04e-05	3	43	2	CID000173737
Drug	diphenylketen	SPIN2A SPIN2B	2.09e-05	4	43	2	CID000013696
Disease	margarate 17:0 measurement	PKD2L1 FREM1	6.74e-05	9	41	2	EFO_0021066
Disease	gestational age, birth measurement	PPP2R3A CACNA2D3	3.89e-04	21	41	2	EFO_0005112, EFO_0006921
Disease	susceptibility to rheumatic fever measurement	MSH3 CACNA2D3	6.96e-04	28	41	2	EFO_0008416
Disease	nitric oxide exhalation measurement	ANK2 CACNA2D3	1.28e-03	38	41	2	EFO_0005536

Protein segments in the cluster

Peptide	Gene	Start	Entry
HDYFGVVDEEVFFQL	CCAR2	66	Q8N163
AEYNSDLHQFFEFLY	BUB1	76	O43683
FETFDVDEYEHYERV	CDC14A	161	Q9UNH5
VHYFSIDNELEYENF	CDC14B	71	O60729
FFGHTHVDEFEVFYD	SMPD1	456	P17405
VAVYDKDEVFHFFNV	EAPP	266	Q56P03
EFLEQHYDRFFSEYE	CAB39	201	Q9Y376
VHYFSIDNELEYENF	CDC14C	41	A4D256
HFFDLYRNSIEFFEE	ANK2	3466	Q01484
YEFIHNFVEVLDEYF	AP4S1	81	Q9Y587
IYFEYSHAFQAVTEF	MSH3	461	P20585
QHITNEYEFRDEYLF	GPR155	816	Q7Z3F1
YQFSEDHDVEYFLRL	GLB1	96	P16278
YAHELQFEYPFEIQV	CD1A	101	P06126
RHDEVELEVYDFFFE	FREM1	381	Q5H8C1
TQYILQHVFYFDEVF	KIF24	266	Q5T7B8
QEHHEEDFFLYIAYS	GABARAP	96	O95166
YFFVELHLEAHYEAL	TUBGCP6	1506	Q96RT7
LEQVYYFLEQQEHFF	MEFV	466	O15553
FYDTFFNLEKYLDHE	PPP2R3A	1051	Q06190
NVFFKQHDYIIEFFD	CD109	341	Q6YHK3
QHDYIIEFFDYTTVL	CD109	346	Q6YHK3
SEEEFFHILEYYDKT	EFCAB6	1471	Q5THR3
FFNIIAYNEELHYVE	CACNA2D3	291	Q8IZS8
TIHFNYRYFEVEEAD	CPOX	256	P36551
QEQEDFFYILFLFIY	OR1A1	21	Q9P1Q5
VIEYDDHEYIFEGFS	DROSHA	591	Q9NRR4
EHLIEFFFRLFADYE	SPEF2	1606	Q9C093
HVLFEDTFFDECYFE	SV2B	466	Q7L1I2
VFYSFEEEHISFALY	NBPF15	631	Q8N660
TSYLHEVFEFYEEIL	TAF2	281	Q6P1X5
IKFDDDFHIYVYDLV	SPIN2A	241	Q99865
VYFFFTEVSVEYEFV	SEMA4D	231	Q92854
FEEIKQFYYRDEFSH	SUPT6H	686	Q7KZ85
YIHDLLKYEFDIEFD	UFC1	71	Q9Y3C8
HTLFYDDFIDFNIIE	RNF125	196	Q96EQ8
SVYFIKFDDDFHIYV	SPIN1	241	Q9Y657
IKFDDDFHIYVYDLV	SPIN3	241	Q5JUX0
IKFDDDFHIYVYDLV	SPIN2B	241	Q9BPZ2
EHYDSFFEEVFTELQ	U2AF1L4	76	Q8WU68
EVIFCVFIFYYVVEE	PKD2L1	356	Q9P0L9
EEGVHEINFLFYYES	TRAPPC8	1041	Q9Y2L5
NYVYFFFREIAVEHN	SEMA6D	231	Q8NFY4
HYYVFFEEQEDEIIG	TSHR	351	P16473