Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontelomerase RNA binding

PARN SMG6

4.08e-0425242GO:0070034
GeneOntologyMolecularFunctionlipoprotein particle receptor binding

LRP1 APOB

9.98e-0439242GO:0070325
GeneOntologyMolecularFunctiontelomeric DNA binding

HNRNPA1 SMG6

1.05e-0340242GO:0042162
GeneOntologyBiologicalProcessmulticellular organismal reproductive process

SLC6A4 SPATA20 PARN APOB GGNBP2 TEX15 ZMIZ1 SPAG17 UMODL1

4.19e-061194249GO:0048609
GeneOntologyBiologicalProcesssexual reproduction

SHOC1 SPATA20 PARN APOB GGNBP2 TEX15 ZMIZ1 SPAG17 UMODL1

9.06e-061312249GO:0019953
GeneOntologyBiologicalProcessregulation of telomere maintenance via telomerase

PARN HNRNPA1 SMG6

4.53e-0560243GO:0032210
GeneOntologyBiologicalProcessregulation of telomere maintenance via telomere lengthening

PARN HNRNPA1 SMG6

6.90e-0569243GO:1904356
GeneOntologyBiologicalProcessgamete generation

SPATA20 PARN APOB GGNBP2 TEX15 ZMIZ1 SPAG17

9.20e-05982247GO:0007276
GeneOntologyBiologicalProcesstelomere maintenance via telomerase

PARN HNRNPA1 SMG6

9.57e-0577243GO:0007004
GeneOntologyBiologicalProcessRNA localization

PARN HNRNPA1 CAPRIN1 SMG6

1.07e-04217244GO:0006403
GeneOntologyBiologicalProcessRNA-templated DNA biosynthetic process

PARN HNRNPA1 SMG6

1.20e-0483243GO:0006278
GeneOntologyBiologicalProcesstelomere maintenance via telomere lengthening

PARN HNRNPA1 SMG6

1.52e-0490243GO:0010833
GeneOntologyBiologicalProcessartery morphogenesis

LRP1 APOB ZMIZ1

1.62e-0492243GO:0048844
GeneOntologyBiologicalProcessregulation of telomere maintenance

PARN HNRNPA1 SMG6

2.90e-04112243GO:0032204
GeneOntologyBiologicalProcessnuclear-transcribed mRNA catabolic process

PARN CAPRIN1 SMG6

4.70e-04132243GO:0000956
GeneOntologyBiologicalProcessartery development

LRP1 APOB ZMIZ1

4.80e-04133243GO:0060840
GeneOntologyBiologicalProcesslipoprotein transport

LRP1 APOB

4.81e-0428242GO:0042953
GeneOntologyBiologicalProcesslipoprotein localization

LRP1 APOB

5.17e-0429242GO:0044872
GeneOntologyBiologicalProcesssynaptonemal complex assembly

SHOC1 TEX15

5.17e-0429242GO:0007130
GeneOntologyBiologicalProcessregulation of DNA biosynthetic process

PARN HNRNPA1 SMG6

5.35e-04138243GO:2000278
GeneOntologyBiologicalProcessregulation of organelle organization

LRP1 PARN XIRP2 HNRNPA1 CAPRIN1 SMG6 FBXW5

6.30e-041342247GO:0033043
GeneOntologyBiologicalProcesssynaptonemal complex organization

SHOC1 TEX15

6.30e-0432242GO:0070193
GeneOntologyBiologicalProcesspositive regulation of telomere maintenance via telomerase

PARN HNRNPA1

7.98e-0436242GO:0032212
GeneOntologyBiologicalProcesspositive regulation of telomere maintenance via telomere lengthening

PARN HNRNPA1

9.37e-0439242GO:1904358
GeneOntologyBiologicalProcesstelomere maintenance

PARN HNRNPA1 SMG6

9.47e-04168243GO:0000723
GeneOntologyBiologicalProcesschromosome organization

SHOC1 PARN TEX15 HNRNPA1 SMG6

1.01e-03686245GO:0051276
GeneOntologyBiologicalProcessnegative regulation of telomere maintenance

HNRNPA1 SMG6

1.09e-0342242GO:0032205
HumanPhenoSpermatocyte maturation arrest

SHOC1 TEX15

5.99e-055132HP:0031039
HumanPhenoObstructive azoospermia

SHOC1 TEX15 SPAG17

8.11e-0535133HP:0011962
MousePhenoabnormal manchette morphology

SPATA20 GGNBP2 SPAG17

3.98e-0545213MP:0009376
MousePhenoabnormal manchette assembly

GGNBP2 SPAG17

9.60e-0510212MP:0031374
MousePhenocardiac hypertrophy

SCNN1B SLC6A4 XIRP2 FBXW5

1.86e-04196214MP:0001625
MousePhenodecreased male germ cell number

SHOC1 SPATA20 APOB GGNBP2 TEX15 SPAG17

2.70e-04640216MP:0004901
MousePhenodecreased germ cell number

SHOC1 SPATA20 APOB GGNBP2 TEX15 SPAG17

3.96e-04687216MP:0002209
MousePhenoarrest of spermatogenesis

SHOC1 GGNBP2 TEX15 SPAG17

3.97e-04239214MP:0001155
DomainQuinoprot_gluc/sorb_DH

LRP1 FBXW5

1.04e-0412242IPR011041
DomainEGF_CA

LRP1 UMODL1

5.42e-0386242PF07645
DomainEGF_Ca-bd_CS

LRP1 UMODL1

6.84e-0397242IPR018097
DomainEGF_CA

LRP1 UMODL1

7.12e-0399242PS01187
DomainASX_HYDROXYL

LRP1 UMODL1

7.25e-03100242PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

LRP1 UMODL1

8.12e-03106242IPR000152
DomainEGF_CA

LRP1 UMODL1

1.06e-02122242SM00179
DomainEGF-like_Ca-bd_dom

LRP1 UMODL1

1.10e-02124242IPR001881
DomainGrowth_fac_rcpt_

LRP1 UMODL1

1.70e-02156242IPR009030
PathwayWP_STATIN_INHIBITION_OF_CHOLESTEROL_PRODUCTION

LRP1 APOB

4.83e-0431152M39514
PathwayPID_AMB2_NEUTROPHILS_PATHWAY

LRP1 APOB

8.46e-0441152M159
PathwayREACTOME_SENSORY_PERCEPTION

SCNN1B LRP1 APOB

9.73e-04190153MM15687
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

LRP1 APOB

1.02e-0345152MM15344
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

LRP1 APOB

1.16e-0348152M27642
Pubmed

Association study of polymorphisms in LRP1, tau and 5-HTT genes and Alzheimer's disease in a sample of Colombian patients.

LRP1 SLC6A4

1.49e-06325216362633
Pubmed

Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice.

LRP1 APOB

2.97e-0642529788969
Pubmed

Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans.

LRP1 APOB

1.04e-05725223676495
Pubmed

Integrative predictive model of coronary artery calcification in atherosclerosis.

SCNN1B LRP1 APOB OLFML2B

2.08e-0522925419948975
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

LRP1 ZFR SPATA20 PARN CAPRIN1 SMG6

5.00e-0596325628671696
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

ZFR APOB GGNBP2 SPAG17 UMODL1 PCDHGA11 HNRNPA1

5.17e-05144225735575683
Pubmed

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

PARN ZMIZ1 SPAG17

1.26e-0413625325429064
Pubmed

Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk.

LRP1 APOB

1.99e-042925220167577
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

LRP1 ZFR APOB CAPRIN1

2.17e-0442025428065597
Pubmed

Genetic associations of brain structural networks in schizophrenia: a preliminary study.

SLC6A4 APOB

2.28e-043125220691427
Pubmed

Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.

ZFR APOB TEX15 CAPRIN1

2.41e-044322547671812
Pubmed

Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.

TEX15 HNRNPA1 CAPRIN1

3.76e-0419725332434143
Pubmed

Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.

LRP1 APOB

4.61e-044425231273033
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

APOB SPAG17 HNRNPA1 SMG6

4.63e-0451325425798074
Pubmed

Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.

LRP1 APOB

5.26e-044725211208732
Pubmed

Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.

ZFR HNRNPA1 CAPRIN1

5.39e-0422325320020773
Pubmed

BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.

ZFR GGNBP2 HNRNPA1

5.60e-0422625325900982
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

ZFR GGNBP2 FBXW5

6.05e-0423225325515538
Pubmed

Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network.

HNRNPA1 CAPRIN1

6.43e-045225226265008
Pubmed

Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1.

ZFR HNRNPA1 CAPRIN1

6.75e-0424125323125841
Pubmed

Study of FOXO1-interacting proteins using TurboID-based proximity labeling technology.

APOB XIRP2 HNRNPA1

6.92e-0424325336964488
Pubmed

Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.

ZFR HNRNPA1 CAPRIN1

7.00e-0424425329884807
InteractionCPE interactions

SLC6A4 LRIF1 CSTL1

3.54e-0554243int:CPE
InteractionUPF1 interactions

SLC6A4 ZFR PARN HNRNPA1 CAPRIN1 SMG6

4.83e-05581246int:UPF1
InteractionSCAI interactions

SLC6A4 HNRNPA1 LRIF1

4.86e-0560243int:SCAI
InteractionADGRV1 interactions

LRP1 SLC6A4 CSTL1

6.46e-0566243int:ADGRV1
InteractionCALCR interactions

LRP1 APOB

1.05e-0413242int:CALCR
InteractionCALR interactions

LRP1 SLC6A4 APOB HNRNPA1 LRIF1

1.10e-04414245int:CALR
Diseasevery low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

SLC6A4 INTS10 PARN APOB

4.64e-05239254EFO_0008317, EFO_0020945
Diseasemigraine disorder, pulse pressure measurement

LRP1 SMG6

2.21e-0426252EFO_0005763, MONDO_0005277
DiseaseColorectal Carcinoma

SCNN1B LRP1 APOB ZMIZ1 SPAG17

2.69e-04702255C0009402
Diseasetriglycerides:total lipids ratio, low density lipoprotein cholesterol measurement

SLC6A4 INTS10 APOB

2.73e-04150253EFO_0004611, EFO_0020947
Diseasedyslexia

SLC6A4 INTS10 GGNBP2

3.42e-04162253EFO_0005424
Diseaselow density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

SLC6A4 INTS10 APOB

6.32e-04200253EFO_0004611, EFO_0020945
Diseaseapolipoprotein A 1 measurement

LRP1 INTS10 APOB ZMIZ1 SMG6

6.38e-04848255EFO_0004614
DiseaseCeliac Disease

APOB ZMIZ1

7.28e-0447252C0007570
Diseasecholesteryl ester 20:3 measurement

PARN APOB

7.91e-0449252EFO_0010347
Diseasevery low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

SLC6A4 INTS10 APOB

8.55e-04222253EFO_0008317, EFO_0020943
Diseasepolyunsaturated fatty acids to monounsaturated fatty acids ratio

INTS10 APOB

8.57e-0451252EFO_0022302
Diseasetriglycerides in medium VLDL measurement

INTS10 APOB

9.96e-0455252EFO_0022155
Diseasecholesterol to total lipids in large HDL percentage

INTS10 APOB

9.96e-0455252EFO_0022234
Diseasetriglycerides in very large VLDL measurement

INTS10 APOB

1.03e-0356252EFO_0022325
Diseasetriglycerides to total lipids in medium HDL percentage

INTS10 APOB

1.03e-0356252EFO_0022333
Diseasetriglycerides in large VLDL measurement

INTS10 APOB

1.03e-0356252EFO_0022178
Diseasecholesteryl esters to total lipids in medium HDL percentage

INTS10 APOB

1.03e-0356252EFO_0022251
Diseasetriglycerides in VLDL measurement

INTS10 APOB

1.14e-0359252EFO_0022326
Diseasecholesterol in medium HDL measurement

INTS10 APOB

1.14e-0359252EFO_0021903
Diseasephospholipids in VLDL measurement

INTS10 APOB

1.14e-0359252EFO_0022301
Diseasetriglycerides to total lipids in large HDL percentage

INTS10 APOB

1.18e-0360252EFO_0022330
Diseasetotal lipids in VLDL measurement

INTS10 APOB

1.18e-0360252EFO_0022314
Diseasecholesterol to total lipids in medium HDL percentage

INTS10 APOB

1.18e-0360252EFO_0022237
Diseasetriglycerides in small VLDL measurement

INTS10 APOB

1.22e-0361252EFO_0022145
Diseasefree cholesterol in very large VLDL measurement

INTS10 APOB

1.22e-0361252EFO_0022274
Diseasefree cholesterol in HDL measurement

INTS10 APOB

1.22e-0361252EFO_0022264
Diseasetriglycerides to total lipids in very large HDL percentage

INTS10 APOB

1.26e-0362252EFO_0022339
Diseasetriglycerides in small HDL measurement

INTS10 APOB

1.26e-0362252EFO_0022158
Diseasephospholipids in large VLDL measurement

INTS10 APOB

1.26e-0362252EFO_0022169
Diseasetotal lipids in very large VLDL measurement

INTS10 APOB

1.26e-0362252EFO_0022313
Diseasephospholipids in very large VLDL measurement

INTS10 APOB

1.26e-0362252EFO_0022299
Diseasecoronary artery disease, plasminogen activator inhibitor 1 measurement

APOB SMG6

1.30e-0363252EFO_0001645, EFO_0004792

Protein segments in the cluster

PeptideGeneStartEntry
RYNFKIQSNNFSYQV

UMODL1

1301

Q5DID0
SRQAQASYYKFQNSD

SMG6

491

Q86US8
KQQNQYQASYNQSFS

CAPRIN1

536

Q14444
NSLQSYQLSPNNYFS

PCDHGA11

166

Q9Y5H2
NFQYENFFNYVTNID

INTS10

616

Q9NVR2
YTLQNHYYRNNSFTA

PARN

546

O95453
NAAYEQSHFFNKNYT

LRIF1

711

Q5T3J3
FMANNQSFYSNREQY

GGNBP2

651

Q9H3C7
NYLYATNSDNANAQQ

LRP1

421

Q07954
YNWSYTQFSQFNKDD

FBXW5

136

Q969U6
NFFIQSYNNASNDTY

CSTL1

46

Q9H114
TQVAYFLANRQNNYD

NBPF3

101

Q9H094
QFNNNEYSQDLDAYN

APOB

1986

P04114
QNFYSDYNTTYSIQA

SCNN1B

371

P51168
DSNANQKEFNSLYFY

SHOC1

1371

Q5VXU9
VDSYNQRNANISYAF

OLFML2B

686

Q68BL8
FFKSELNQLYQSQYN

SPAG17

1911

Q6Q759
NTFAQYQYQHQNRSE

XIRP2

96

A4UGR9
YDQAQLAVAYSQAFQ

SPATA20

336

Q8TB22
AVYSAASSYYQQQQQ

ZFR

271

Q96KR1
SNLAQFDSDFYQSNF

YIPF7

26

Q8N8F6
YSKESNYFYSSTQNN

TEX15

746

Q9BXT5
SYNDFGNYNNQSSNF

HNRNPA1

311

P09651
AFASYNKFNNNCYQD

SLC6A4

346

P31645
NGQNNTFSGSSYSNY

ZMIZ1

476

Q9ULJ6