Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR1J1 OR6K2 OR2G6 OR2J1 OR2J2 OR2T4 OR1L1 OR52N4 OR10AC1 OR10K2 OR7G3

6.83e-0543112211GO:0004984
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR1J1 OR6K2 OR2G6 OR2J1 OR2J2 TLR6 OR2T4 OR1L1 OR52N4 OR10AC1 TAS1R1 OR10K2 OR7G3

1.39e-0552412213GO:0009593
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR1J1 OR6K2 OR2G6 OR2J1 OR2J2 OR2T4 OR1L1 OR52N4 OR10AC1 TAS1R1 OR10K2 OR7G3

3.12e-0548512212GO:0050907
GeneOntologyBiologicalProcessresponse to dsDNA

RIOK3 EPG5

3.47e-0521222GO:1990784
GeneOntologyBiologicalProcesscellular response to dsDNA

RIOK3 EPG5

3.47e-0521222GO:1990786
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR1J1 OR6K2 OR2G6 OR2J1 OR2J2 OR2T4 OR1L1 OR52N4 OR10AC1 OR10K2 OR7G3

5.23e-0543212211GO:0050911
GeneOntologyBiologicalProcessdetection of stimulus

OR1J1 OR6K2 OR2G6 OR2J1 OR2J2 TLR6 OR2T4 OR1L1 NOD1 OR52N4 OR10AC1 TAS1R1 OR10K2 OR7G3

9.52e-0572212214GO:0051606
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR1J1 OR6K2 OR2G6 OR2J1 OR2J2 OR2T4 OR1L1 OR52N4 OR10AC1 TAS1R1 OR10K2 OR7G3

9.86e-0554712212GO:0007606
GeneOntologyBiologicalProcesssensory perception of smell

OR1J1 OR6K2 OR2G6 OR2J1 OR2J2 OR2T4 OR1L1 OR52N4 OR10AC1 OR10K2 OR7G3

1.01e-0446512211GO:0007608
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR1J1 OR6K2 OR2G6 OR2J1 OR2J2 OR2T4 OR1L1 OR52N4 OR10AC1 TAS1R1 OR10K2 OR7G3

1.76e-0458212212GO:0050906
GeneOntologyBiologicalProcessnegative regulation of MDA-5 signaling pathway

DHX58 RIOK3

2.07e-0441222GO:0039534
DomainDUF3585

EHBP1 MICALL1 MICALL2

8.88e-0671203IPR022735
DomainDUF3585

EHBP1 MICALL1 MICALL2

8.88e-0671203PF12130
DomainLIM

LMO4 ZYX MICALL1 TGFB1I1 MICALL2

8.15e-05691205PF00412
Domain-

LMO4 ZYX MICALL1 TGFB1I1 MICALL2

8.73e-057012052.10.110.10
DomainZnf_LIM

LMO4 ZYX MICALL1 TGFB1I1 MICALL2

9.34e-05711205IPR001781
DomainLIM_DOMAIN_1

LMO4 ZYX MICALL1 TGFB1I1 MICALL2

9.34e-05711205PS00478
DomainLIM_DOMAIN_2

LMO4 ZYX MICALL1 TGFB1I1 MICALL2

9.34e-05711205PS50023
DomainLIM

LMO4 ZYX MICALL1 TGFB1I1 MICALL2

9.34e-05711205SM00132
DomainOlfact_rcpt

OR1J1 OR6K2 OR2G6 OR2J1 OR2J2 OR2T4 OR1L1 OR52N4 OR10K2 OR7G3

2.26e-0439312010IPR000725
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR1J1 OR6K2 OR2G6 OR2J1 OR2J2 OR2T4 OR1L1 OR52N4 OR10AC1 OR10K2 OR7G3

3.96e-054178511M4072
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR1J1 OR6K2 OR2J1 OR2J2 OR2T4 OR52N4 OR10AC1 OR10K2 OR7G3

3.88e-06340124911802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR1J1 OR6K2 OR2J1 OR2J2 OR2T4 OR52N4 OR10AC1 OR10K2 OR7G3

4.17e-06343124932295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR1J1 OR6K2 OR2J1 OR2J2 OR2T4 OR52N4 OR10AC1 OR10K2 OR7G3

4.48e-06346124914611657
Pubmed

EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells.

EHBP1 MICALL1 MICALL2

1.23e-0513124326833786
Pubmed

The human olfactory receptor gene family.

OR1J1 OR6K2 OR2J1 OR2J2 OR2T4 OR1L1 OR52N4 OR10AC1 OR10K2 OR7G3

2.56e-055411241014983052
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR1J1 OR6K2 OR2J1 OR2J2 OR2T4 OR52N4 OR10K2 OR7G3

3.16e-05340124811875048
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

SEL1L CAND2 DNAH2 PDCD2L EMC8 URB1 ARHGEF40 PNPLA6 NISCH GEMIN4 RHBDD3 ATXN10 NUP188

3.35e-059421241331073040
Pubmed

The Salmonella type III effector SspH2 specifically exploits the NLR co-chaperone activity of SGT1 to subvert immunity.

ECD NOD1

3.77e-053124223935490
Pubmed

Inducible knockout of CHUK/IKKα in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis.

CHUK ACAN

3.77e-053124231222033
Pubmed

The DNA sequence, annotation and analysis of human chromosome 3.

EEFSEC CAND2 HYAL3 EFCC1

7.32e-0562124416641997
Pubmed

Antibodies to proteinase 3 prime human monocytic cells via protease-activated receptor-2 and NF-kappaB for Toll-like receptor- and NOD-dependent activation.

PRTN3 NOD1

7.53e-054124217452051
Pubmed

5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.

CAND2 ATR ATXN10

1.22e-0427124323027611
Pubmed

MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.

MICALL1 MICALL2

1.25e-045124212110185
Pubmed

The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.

MICALL1 MICALL2

1.25e-045124218094055
Pubmed

Odorant and vomeronasal receptor genes in two mouse genome assemblies.

OR2T4 OR52N4 OR10AC1 OR7G3

1.46e-0474124415081110
Pubmed

Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis.

GPR143 HPS6

1.87e-046124222984402
Pubmed

Genetic labeling of Tas1r1 and Tas2r131 taste receptor cells in mice.

ENTPD2 TAS1R1

1.87e-046124223010799
Pubmed

Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1.

DHX58 RNASEL

2.62e-047124234343497
Pubmed

Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease.

TLR6 NOD1

2.62e-047124217595233
Pubmed

Differential development of odorant receptor expression patterns in the olfactory epithelium: a quantitative analysis in the mouse septal organ.

OR10AC1 OR10K2

2.62e-047124218214836
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

EHBP1 PITPNM2 STRN3 ECD RIOK3 PDCD2L ZYX CHUK TGFB1I1 HPS6 GSTCD CNOT1

3.49e-0410381241226673895
Pubmed

Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes.

PHF2 ACAN

4.47e-049124224276541
Pubmed

Proteomics characterization of extracellular space components in the human aorta.

COL6A3 PRTN3 TGFB1I1 ACAN

4.81e-04101124420551380
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PITPNM2 MAN2A2 MICALL1 URB1 ARHGEF40 PNPLA6 NISCH HPS6 ENTPD2 FLCN TANC1 NUP188

6.07e-0411051241235748872
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PITPNM2 ISLR2 CAND2 MICALL1 AMIGO3 NUP188 CPSF2 CNOT1

6.41e-04529124814621295
Pubmed

Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer.

EHBP1 EEFSEC

6.79e-0411124220878950
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

ATR ARHGEF40 ANAPC1 CNOT1 ADPGK

8.10e-04202124533005030
Pubmed

Pathogen recognition in the innate immune response.

TLR6 CHUK

8.13e-0412124219382893
Pubmed

Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex.

OR2J1 OR2J2

9.59e-0413124214506126
Pubmed

Defining the membrane proteome of NK cells.

NVL PDCD2L EMC8 PNPLA6 NISCH HPS6 GEMIN4 ATXN10 NUP188 CPSF2 CNOT1 ADPGK

9.82e-0411681241219946888
Pubmed

Proximity labeling reveals dynamic changes in the SQSTM1 protein network.

RIOK3 CHUK ANAPC1 TANC1 ATXN10 CNOT1

1.08e-03322124639098523
Pubmed

Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies.

PATL2 CNOT1

1.12e-0314124220584987
Pubmed

A trans-eQTL network regulates osteoclast multinucleation and bone mass.

ATP8B2 TGFB1I1

1.12e-0314124232553114
Pubmed

Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients.

TLR6 NOD1

1.12e-0314124220595247
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

SEL1L MAN2A2 ATR LAMA4 WDR25 EMC8 MGAT5 HYAL3 FLCN CPSF2 SUCO ADPGK

1.24e-0312011241235696571
Pubmed

Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.

COL6A3 NVL EMC8 CHUK

1.71e-03142124419851296
Pubmed

Association of genetic variants with hemorrhagic stroke in Japanese individuals.

COL6A3 NVL EMC8 CHUK

1.75e-03143124420198315
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

COL6A3 MAN2A2 CAND2 LAMA4 RIOK3 ATXN10 ADPGK

2.09e-03497124723414517
Pubmed

Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.

LMO4 TAS1R1

2.30e-0320124221738478
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

EEFSEC ATR NOL6 ZNF629 COLGALT2 ARHGEF40 NISCH TANC1

2.36e-03650124838777146
Pubmed

A Transcription Factor Etv1/Er81 Is Involved in the Differentiation of Sweet, Umami, and Sodium Taste Cells.

ENTPD2 TAS1R1

2.53e-0321124237045597
Pubmed

BDNF and NT4 play interchangeable roles in gustatory development.

ISLR2 CHUK

3.04e-0323124224378336
Pubmed

Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.

EHBP1 MGAT5

3.04e-0323124220468071
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

EEFSEC NVL CHUK MGAT5 ATXN10 CPSF2 CNOT1

3.08e-03533124725544563
Pubmed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

SEL1L ECD EMC8 PNPLA6 NISCH ATXN10 CPSF2 ADPGK

3.27e-03686124828380382
Pubmed

Exploring the link between MORF4L1 and risk of breast cancer.

ATR CHUK

3.31e-0324124221466675
Pubmed

Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping.

POLR3H MICALL1

3.31e-0324124211258795
Pubmed

Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways.

TLR6 CHUK

3.31e-0324124220448286
Cytoband9q33.2

ZBTB6 OR1J1 OR1L1

1.64e-043912439q33.2
GeneFamilyLIM domain containing

LMO4 ZYX MICALL1 TGFB1I1 MICALL2

5.48e-06597851218
DiseaseNephronophthisis

ATXN10 SLC41A1

1.16e-03131162C0687120
Diseasebody fat distribution

PITPNM2 COLGALT2 MICALL2 ACAN B4GALNT3

1.24e-032021165EFO_0004341
DiseasePneumoconiosis

ATR ACAN

1.35e-03141162C0032273
DiseaseBagassosis

ATR ACAN

1.35e-03141162C0004681
Diseasesexual dimorphism measurement

PITPNM2 HAGHL RIOK3 OR2J1 COLGALT2 LACTBL1 PARP10 ARHGEF40 ACAN B4GALNT3 ALDH3B2 SUCO

1.39e-03110611612EFO_0021796

Protein segments in the cluster

PeptideGeneStartEntry
GCPGDHLFLLNHILR

EPG5

471

Q9HCE0
HLFLLNHILRCPAGV

EPG5

476

Q9HCE0
HREGISFHFTPVLVC

ADPGK

456

Q9BRR6
LFHGCPLITDHSREV

AMN1

226

Q8IY45
HPLRIGACFLRHGDQ

ARHGEF40

1151

Q8TER5
NPFQFRHLSLCHGLS

CPSF2

301

Q9P2I0
FLCDLHIHFPAGVID

B4GALNT3

876

Q6L9W6
HAFPELFLSCLNHPD

ATXN10

156

Q9UBB4
CPAARHLAVYLLDHF

CCNJL

56

Q8IV13
FSHHRTCLLAPSGLE

ALDH3B2

341

P48448
HAGLFVCLATGPRLH

AMIGO3

346

Q86WK7
LHRAHCFLPAGIVAV

ECD

206

O95905
EVFHHLDCRGAGRLP

EFCC1

61

Q9HA90
PHTHEFFRLLSLCHT

ATP8B2

481

P98198
RAGLAFVLHCIADGH

ISLR2

251

Q6UXK2
NHLEHIFCDFLPVLR

OR6K2

171

Q8NGY2
RFGAIHVRCLLTPGH

HAGHL

96

Q6PII5
LRLPQAFDFCHLAHL

NVL

451

O15381
AFDFCHLAHLTPGFV

NVL

456

O15381
CHRGLLALSSPYFHA

KLHL30

46

Q0D2K2
IAALLCALYPHFPAH

ANAPC1

1581

Q9H1A4
SCFELLHRAVGHFEL

ASB8

206

Q9H765
LGHFEKPLFLELCRH

PNPLA6

196

Q8IY17
AIFHLPFCGSRLLLH

OR10AC1

166

Q8NH08
RHRLVDHFFCEVPAL

OR2J1

171

Q9GZK6
FFSHRFGEHIIPPSC

OR52N4

261

Q8NGI2
AAARRLHVLPCLHAF

TRIM71

51

Q2Q1W2
FSHGELPPHCEQRFL

MAEL

121

Q96JY0
HPAIHDILALRECFS

LETMD1

226

Q6P1Q0
ALCHFCELHGPRTLF

FLCN

6

Q8NFG4
GDLLLFSCAGAHPRH

MGAT5

706

Q09328
CLLVHGPLDHFFPES

GPR179

2276

Q6PRD1
FCEHDRPTALINGHL

LMO4

136

P61968
FAHFPRLISLHSLCL

LRRTM1

226

Q86UE6
VFECIAGYRPFLHHL

CHUK

211

O15111
FSEFPCHFLHRELPK

CFAP65

1631

Q6ZU64
GFITKHPLLSRFACH

MAPK8IP2

771

Q13387
FRTGLREEHLACFGH

CCDC97

111

Q96F63
RLLASALQTHGFHPC

ENTPD2

251

Q9Y5L3
FCAILHRHRPDLINF

MICALL2

36

Q8IY33
TFLLFSCPHRLREHL

FCGRT

176

P55899
KLHFHPSNCLAVRAF

KLHL8

161

Q9P2G9
RGSREIHHFFCEVPA

OR2T4

201

Q8NH00
LEGSPFHRLLHVFAC

PDCD2L

66

Q9BRP1
AHHLAQDPLFGSVCF

NOL6

211

Q9H6R4
DCSALSFVLHHFPKR

NOD1

691

Q9Y239
AFCAILHRHRPDLLD

MICALL1

36

Q8N3F8
GHLHVLDELCVFAFG

KCNS1

121

Q96KK3
DHIIPHYFCDLGALL

OR1J1

171

Q8NGS3
GHRLVDHFFCEVPAL

OR2J2

171

O76002
SFCDGLVHDPLRHKA

PITPNM2

1176

Q9BZ72
IHPSFVLTAAHCLRD

PRTN3

61

P24158
GLPDPLSRHHAFCFR

ACAN

661

P16112
CVLLLVLSFCIPHFH

OR1L1

191

Q8NH94
VLSFCIPHFHSLLHI

OR1L1

196

Q8NH94
KSLHAEFLPCRFHRL

GLYATL3

261

Q5SZD4
LAFPSNLLPLFCHHV

PATL2

511

C9JE40
TPSLVFLCFIFDGLH

EBLN1

76

P0CF75
PFSEHGHVDLFCRNL

ATR

731

Q13535
FQLHVAHEFPCALPL

LACTBL1

436

A8MY62
SGLIFTHHPCFSREH

CC2D2A

411

Q9P2K1
LSLLTAHPLHFACLF

C6orf47

236

O95873
AHPLHFACLFGLLQA

C6orf47

241

O95873
VLSFQPRAFHALCLG

GPR143

21

P51810
HLPLVAVFCLFLSGF

COL6A3

6

P12111
RPRTSHHGCFLLRFH

FSCN3

86

Q9NQT6
HCEARFGVHLPLNAL

HYAL3

41

O43820
PRAGFGHLARCHDLL

DHX58

86

Q96C10
LSFCAILHHFRPDLI

EHBP1

476

Q8NDI1
FHPLASSLPCDFHLL

MAN2A2

1041

P49641
HTLFVDCIPLFHGTL

EMC8

51

O43402
HTLPHFLGCLERLDY

COLGALT2

66

Q8IYK4
HGRDGTRFCHLLDLP

HHIPL2

161

Q6UWX4
THVLLHHCPAFGLLA

HPS6

181

Q86YV9
GVPLGAFHASLLHCL

CAND2

166

O75155
RRTQDFPSDHHCLFL

C4orf54

121

D6RIA3
FFDLTFHHLCPSKRP

DNAH2

2676

Q9P225
LDFSHQTEGCIFPLH

GSTCD

16

Q8NEC7
HVLCLEHPGSARFLL

PARP10

511

Q53GL7
GCIRHFVIDGHPVSF

LAMA4

1791

Q16363
RLCGHSAFPHLRVLE

PAOX

31

Q6QHF9
HFFCDIAPVLKLASH

OR10K2

176

Q6IF99
LPLCGHRTLDHIFCE

OR2G6

166

Q5TZ20
THAALAALRGHFCLS

OIP5

151

O43482
HLAADFRHCRGGLPD

FAN1

946

Q9Y2M0
ARIDHFLLQHSIPGC

UBOX5

326

O94941
LRSHFDGVRALAFHP

STRN3

476

Q13033
PVDCLAFAGHFLHSL

PHF2

326

O75151
TAHGEPCHFPFLFLD

SEL1L

121

Q9UBV2
FHVPAGLLALFTLRH

TMEM170A

61

Q8WVE7
DLEIPHFFCELAHIL

OR7G3

171

Q8NG95
AICRHTILRSHFFLP

POU6F2

521

P78424
CHRLGLCVSRHPVFF

PTCHD4

31

Q6ZW05
FRNHLGRYCLEHLPA

SH2D5

346

Q6ZV89
LLDHVRSGSCFHALP

SLC39A4

186

Q6P5W5
LAVFCHELPHELGDF

SLC39A4

531

Q6P5W5
LFHPGEHVRDCLSDL

RNASEL

566

Q05823
EHVRDCLSDLLGHPF

RNASEL

571

Q05823
LDLDHSCGHRFLGRS

SOCS4

76

Q8WXH5
AFLCEPRNGHALLAF

TANC1

831

Q9C0D5
DGHFSIPHAFLLCAS

SLC41A1

206

Q8IVJ1
HFRCVVFHPFLDEIL

POLR3H

71

Q9Y535
FHIILSFFHSPLCDE

URB1

1811

O60287
VIHHLFAFLGFLGCL

CLN8

136

Q9UBY8
PEADRHLLRCLFSHV

CNOT1

41

A5YKK6
HLLRCLFSHVDFSGD

CNOT1

46

A5YKK6
ECHLGTLRFLHASAL

RHBDD3

81

Q9Y3P4
THPHGLEFLFRDCRN

RIOK3

431

O14730
FCKRAFPSGHLLDAH

ZNF511

111

Q8NB15
TCRLAFHGILLHGLE

EEFSEC

441

P57772
AFRDCSGLTAHLLIH

ZNF880

416

Q6PDB4
CLRVHLASHAGELPF

ZNF668

126

Q96K58
FSLLLDVFCALHGPR

TMEM68

166

Q96MH6
AGLFPLHSGCLQVRH

TAS1R1

41

Q7RTX1
LYDFHEDLLLHCGVP

RYR3

1896

Q15413
QHILSSLRFVFCFPH

NISCH

751

Q9Y2I1
CLLPGFRVLNDFLAH

WDFY4

1696

Q6ZS81
CPPLLHRAAIAFLHA

NUP188

976

Q5SRE5
GLLALRPFHTHSCAR

PHOSPHO1

156

Q8TCT1
LLSHFGSEHFCPLSL

SUCO

431

Q9UBS9
LLALCAPLFLPQHHF

PLEKHH1

921

Q9ULM0
SCHPIVSFRHLDLSF

TLR6

116

Q9Y2C9
DFLHVFTLRLHCGPA

nan

141

Q0VFX4
LLHFPRDHSNCSLSF

ZACN

161

Q401N2
PAVRALGQLFHIACF

ZYX

396

Q15942
CVSALGRRFHPDHFT

TGFB1I1

416

O43294
QIFHERFTCPSLALH

WDR25

421

Q64LD2
FTEVAALLLHRSCHP

ZNF629

851

Q9UEG4
FPGCGLLRLHSTFRH

PPIP5K1

556

Q6PFW1
RCFFHLVLGGHRLEP

TMEM249

151

Q2WGJ8
CPRGFLHVENYLRHL

ZBTB6

306

Q15916
ETIFVGCEFLHHLLR

GEMIN4

311

P57678